OOIR: Observatory of International Research

Papers

(The TQCC of Anti-Cancer Drugs is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Rapid and durable response to fifth-line lorlatinib plus olaparib in an ALK-rearranged, BRCA2-mutated metastatic lung adenocarcinoma patient with critical tracheal stenosis: a case report	58
Circ_0003998 upregulates ARK5 expression to elevate 5-Fluorouracil resistance in hepatocellular carcinoma through binding to miR-513a-5p	28
BTK inhibitors enhance NKG2D ligand expression by regulating IL-10/STAT3 pathway in activated non-GCB diffuse large B-cell lymphoma cells	24
FV-429 suppresses cancer cell migration and invasion by EMT via the Hippo/YAP1 pathway in pancreatic cancer cells	21
Hypoxia-inducible factor-1α inhibition augments efficacy of programmed cell death 1 antibody in murine prostatic cancer models	20
A retrospective assessment of real-world experience with venetoclax and azacitidine therapy in elderly acute myeloid leukemia	19
YKL-06-061 exerts antitumor effect through G1/S phase arrest by downregulating c-Myc and inhibition of metastasis via SIK1 upregulation in pancreatic cancer	17
Circular RNA circ_0073181 contributes to tumorigenesis by regulating protein tyrosine phosphatase receptor type E via miR-548p in hepatocellular carcinoma	16
First-line lorlatinib treatment in a 19-year-old patient with ALK-rearranged pulmonary large-cell neuroendocrine carcinoma: a case report and literature review	16
Complete response of recurrent perihilar cholangiocarcinoma following sintilimab combined with lenvatinib plus S-1: a case report and review of literature	16
CircRNA B cell linker regulates cisplatin sensitivity in nonsmall cell lung cancer via microRNA-25-3p/BarH‑like homeobox 2 axis	16
LncRNA FOXP4-AS1 silencing inhibits metastasis and epithelial–mesenchymal transition in nasopharyngeal carcinoma via miR-136-5p/MAPK1	16
Acquired EML4-ALK fusion and EGFR C797S in cis mutation as resistance mechanisms to osimertinib in a non-small cell lung cancer patient with EGFR L858R/T790M	15
Aumolertinib-based comprehensive treatment for an uncommon site of EGFR exon 20 insertion mutations with multiple metastases non-small cell lung cancer: a case report	15
Partial response of metastatic cardia neuroendocrine carcinoma with the combined therapy involving PD-1 blockade after failed multi-line chemotherapies: a case report and literature review	15
Knockdown of circLRWD1 weakens DDP resistance via reduction of SIRT5 expression through releasing miR-507 in non-small cell lung cancer	15
Nivolumab combined docetaxel versus nivolumab in patients with previously treated nonsmall cell lung cancer: a phase 2 study	14
Interference with PLA2G16 promotes cell cycle arrest and apoptosis and inhibits the reprogramming of glucose metabolism in multiple myeloma cells by modulating the Hippo/YAP signaling pathway	14
WISP1 inhibition of YAP phosphorylation drives breast cancer growth and chemoresistance via TEAD4 activation	14
Anoikis-related lncRNA signature predicts prognosis and is associated with immune infiltration in hepatocellular carcinoma	13
Circ_0005615 contributes to the progression and Bortezomib resistance of multiple myeloma by sponging miR-185-5p and upregulating IRF4	13
Neutrophil-to-lymphocyte ratio predicts therapy outcomes of transarterial chemoembolization combined with tyrosine kinase inhibitors plus programmed cell death ligand 1 antibody for unresectable hepat	13
HER2-positive advanced biliary tract cancer responds to second-line pyrotinib therapy: a case report	12
Remarkable response to gemcitabine rechallenge in advanced urothelial carcinoma: a case report	12
Computational study of novel natural inhibitors targeting Kirsten rat sarcoma viral oncogene homolog G12C	12

Venetoclax-induced vitiligo in a patient with chronic lymphocytic leukemia	12
APLNR promotes the progression of osteosarcoma by stimulating cell proliferation and invasion: Retraction	12
Identification of exosomal circRNA CD226 as a potent driver of nonsmall cell lung cancer through miR-1224-3p/high mobility group AT-hook 2 axis	11
Real-life data on adjuvant trastuzumab emtansine treatment in early-stage HER2-positive breast cancer: a Turkish Oncology Group study	11
Transcription factor ZEB1 regulates PLK1-mediated SKA3 phosphorylation to promote lung cancer cell proliferation, migration and cell cycle	11
Distribution of side effects of anti-EGFR treatments in patients with metastatic colorectal cancer and evaluation of their relationship with survival	11
TRIM11 expression levels was downregulated and prevents ferroptosis of cardiomyocyte by Dusp6 in acute myocardial infarction	11
Bevacizumab and anexelekto inhibitor, TP-0903 inhibits TGF-β1-induced epithelial–mesenchymal transition of colon cancer cells	11
Novel dibenzoylmethane derivative 2-allyl-1,3-diphenyl-1, 3-propanedione: a safe and effective topical treatment for melanoma	11
M2 tumor-associated macrophage promoted DNA methylation in lung cancer metastasis via intensifying EZH2	11
Tislelizumab plus chemotherapy is an optimal option for second-line treatment for advanced gastroesophageal junction adenocarcinoma	10
Multimodal treatment with cisplatin for metastatic disease in malignant peripheral nerve sheath tumors: a case report and review	10
Successful immunotherapy with PD-1 Iinhibitor for advanced pancreatic cancer: report of two cases and review of literature	10
miR-26b-5p suppresses chemoresistance in breast cancer by targeting serglycin	9
Circ_0009035 regulates the progression of cervical cancer by targeting miR-1305/CREBRF axis	9
Epidermal growth factor receptor mutation p.A864V in small cell lung cancer and lung squamous cell carcinoma: a case report and review of literature	9
DNA methyltransferase inhibitor 5-azacytidine enhances neuroblastoma cell lysis by an oncolytic parainfluenza virus	9
α-Asarone attenuates tumor-associated macrophages-induced gemcitabine resistance in pancreatic carcinoma via the transforming growth factor-beta 1/growth factor independent 1 axis	9
Electrochemotherapy with bleomycin as an effective local treatment for Kaposi’s sarcoma: a case report	9
MiR-30a-5p/CHD1 axis enhances cisplatin sensitivity of ovarian cancer cells via inactivating the Wnt/β-catenin pathway	9
CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression	8
Nivolumab- and ipilimumab-induced myositis, myasthenia gravis, and myocarditis in a patient with metastatic melanoma	8
Successful treatment with lenvatinib in a patient with thymic carcinoma presenting with cardiac tamponade: a case report and review of literature	8
Biodegradable controlled-release polymer containing butylidenephthalide to treat a recurrent cervical spine glioblastoma with promising result: a compassionate trial report	8
Complete response with trastuzumab in heavily pretreated HER2-positive metastatic salivary duct carcinoma	8
Extended survival in a case of metastatic choroidal melanoma with immunotherapy	8
Salvage chemotherapy in patients with nonsmall cell lung cancer after prior immunotherapy: a retrospective, real-life experience study	8
Circ_0001658 regulates gefitinib resistance of non-small cell lung cancer through miR-409-3p/TWIST1 axis	8
A case of diabetic ketoacidosis triggered by immune checkpoint inhibitors in the treatment of recurrent nasopharyngeal carcinoma	8
Transcriptional regulation of CYR61 and CTGF by LM98: a synthetic YAP-TEAD inhibitor that targets in-vitro vasculogenic mimicry in glioblastoma cells	8
Anlotinib for the treatment of pulmonary epithelioid inflammatory myofibroblastic sarcoma: a case report	8
Identifying predictive biomarkers of apatinib in third-line treatment of advanced colorectal cancer through comprehensive genomic profiling	8
HMOX1 regulates ferroptosis via mic14 and its impact on chemotherapy resistance in small-cell lung cancer	8
Long-term survival of an ALK fusion lung adenocarcinoma patient with high mutation burden and microsatellite instability high: a case report	7
Clinical and radiological evaluation of a phyllodes tumor of the breast: a case report	7
Pyrotinib for HER2-amplified non-small cell lung cancer patient after progression to Afatinib: a case report	7
Complete response to first-line osimertinib monotherapy in a complex epidermal growth factor receptor mutant (L833V/H835L) lung adenocarcinoma patient: a case report	7
Kruppel-like factor 5 enhances proliferation, lipid droplet formation and oxaliplatin resistance in colorectal cancer by promoting fatty acid binding protein 6 transcription	7
CDKN2A inhibited ferroptosis through activating JAK2/STAT3 pathway to modulate cisplatin resistance in cervical squamous cell carcinoma	7
Diagnostic and prognostic value of serum soluble B7-H3 in nonsmall cell lung cancer	7
What management for epidermal growth factor receptor-mutated non–small-cell lung cancer, with squamous cell transformation and T790M-acquired resistance mechanisms? A Case report and review of literat	7
Ado-trastuzumab emtansine in the treatment of lung adenocarcinoma with ERBB2 mutation: a case report and literature review	7
Hemodialysis requirement after the first dose of durvalumab following chemoradiation therapy: a case report	7
Reuse of osimertinib after small cell lung cancer transformation in lung adenocarcinoma with de-novo epidermal growth factor receptor T790M mutation: case report	7
Immunotherapy combined with chemotherapy in the treatment for rare primary mucoepidermoid carcinoma of the liver: a case report	7
Apoptotic and autophagic cell death induced in cervical cancer cells by a dual specific oncolytic adenovirus	7
Expression and clinical significance of CXCL17 and GPR35 in endometrial carcinoma	7
A late relapse thymoma and pure red cell aplasia case with an over 5 years of clinical response under everolimus	7
Differential functionality of fluoropyrimidine nucleosides for safe cancer therapy	7
GATA3 positively regulates PAR1 to facilitate in vitro disease progression and decrease cisplatin sensitivity in neuroblastoma via inhibiting the hippo pathway	7

Blocking circ_0010235 suppresses acquired paclitaxel resistance of non-small cell lung cancer by sponging miR-512-5p to modulate FAM83F expression	7
Concurrent NRAS-BRAF variants in metastatic colorectal cancer: a Tunisian case report	6
Efficacy and safety of sintilimab combined with apatinib as third-line or above therapy for patients with advanced or metastatic gastric cancer	6
Berberine inhibits prostate cancer progression by inducing ferroptosis: evidence from network pharmacology	6
Utidelone plus pembrolizumab as the fourth-line combination treatment in non-small cell lung cancer with EGFR mutation: a case report	6
Mechanism of gemcitabine combined with lobaplatin in interventional treatment of locally advanced cervical cancer	6
Dexmedetomidine disrupts esophagus cancer tumorigenesis by modulating circ_0003340/miR-198/HMGA2 axis	6
Antineoplastic activity of GP-2250 in-vitro and in mouse xenograft models	6
Exosomal miR-93-5p from cancer-associated fibroblasts confers malignant phenotypes on bladder cancer cells by targeting PAFAH1B1	6
MiR-302c-5p affects the stemness and cisplatin resistance of nasopharyngeal carcinoma cells by regulating HSP90AA1	6
Immunotherapy rechallenge of advanced lung adenocarcinoma with cadonilimab (PD-1/CTLA-4 Bi-specific antibody): a case report	6
Potential mechanism of pyrotinib-induced diarrhea was explored by gut microbiome and ileum metabolomics	6
M2 macrophage-derived exosomal miR-1911-5p promotes cell migration and invasion in lung adenocarcinoma by down-regulating CELF2-activated ZBTB4 expression	6
Exosomal circ_0007385 enhances non-small cell lung cancer cell proliferation and stemness via regulating miR-1253/FAM83A axis	6
Exploring the repurposing potential of telmisartan drug in breast cancer: an in-silico and in-vitro approach	6
Pathological complete response achieved with FLOT chemotherapy in two patients with MSI-H esophagogastric junction and gastric adenocarcinoma	6
A dual thermo/pH-sensitive hydrogel as 5-Fluorouracil carrier for breast cancer treatment	6
Mucinous appendiceal adenocarcinoma invading the bladder: not always an easy diagnosis. A case report	6
AZD7762 induces CRBN dependent BAG3 degradation through ubiquitin-proteasome pathway	6
Lidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis	6
Stewart-Treves syndrome in an older woman successfully treated by metronomic chemotherapy: case report and literature survey	6
Response to erlotinib and bevacizumab combination therapy after acquired resistance to osimertinib in patients with non-small cell lung cancer	6
GZ17-6.02 interacts with carboplatin and etoposide to kill neuroblastoma cells	6
Azacitidine combined with venetoclax alleviates AML-MR with TP53 mutation in SDS: a case report and literature review	6
Efficacy of disitamab vedotin (RC48) for previously treated human epidermal growth factor receptor 2–positive breast cancer with symptomatic brain metastases: a case report and review of the literatur	5
Stat3 shRNA delivery with folate receptor-modified multi-functionalized graphene oxide particles for combined infrared radiation and gene therapy in hepatocellular carcinoma	5
Natural products inducing nucleolar stress: implications in cancer therapy	5
Combined protein and transcriptomics identifies DCTPP1 as a putative biomarkers for predicting immunotherapy responsiveness in gastric cancer patients	5
The mTOR pathway inhibition with everolimus in pseudomyogenic hemangioendothelioma harboring SERPINE1-FOSB gene fusion: a case report and review of the literature	5
Combating anoikis resistance: bioactive compounds transforming prostate cancer therapy	5
Hyper-late major response after 5 years of nivolumab: role of treatment beyond progression in head and neck cancer	5
A review of research progress on mechanisms and overcoming strategies of acquired osimertinib resistance	5
Association between SLCO1B1 polymorphism and methotrexate-induced hepatotoxicity: a systematic review and meta-analysis	5
Circ_0058063 promotes progression of thyroid cancer by sponging miR-330-3p/SDC4 axis	5
BAP1 loss confers sensitivity to bromodomain and extra-terminal inhibitors in renal cell carcinoma	5
Research on the mechanism of eugenol in the treatment of liver cancer based on network pharmacology, molecular docking technology, and in vitro experiments	5
Patient-derived organoid modeling predicts personalized drug responses in prostate-metastatic mantle cell lymphoma: a case report	5
First-line crizotinib therapy is effective for a novel SEC31A-anaplastic lymphoma kinase fusion in a patient with stage IV lung adenocarcinoma: a case report and literature reviews	5
Effect of metformin use on the risk and prognosis of colorectal cancer in diabetes mellitus: a meta-analysis	5
USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis	5
Pretreatment platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio as a predictor of pathological complete response to neoadjuvant chemotherapy in patients with breast cancer: single center	5
First case report of sunvozertinib for the treatment of HER2 exon 20 insertion in lung adenocarcinoma	5
Methyltransferase-like 3 enhances cell proliferation and cisplatin resistance in natural killer/T-cell lymphoma through promoting N6-methyladenosine modification and the stability of staphylococcal nu	5
The mechanism of circ-PIP5K1A/miR-942-5p/NFIB axis in cisplatin resistance in ovarian cancer based on imaging and molecular diagnosis	5
In regard to Cabezas-Camarero et al.	5
Design of potential anti-cancer agents as COX-2 inhibitors, using 3D-QSAR modeling, molecular docking, oral bioavailability proprieties, and molecular dynamics simulation: Erratum	5
Unexpected response to fourth-line paclitaxel in a patient with metastatic oropharyngeal squamous cell carcinoma, immunotherapy-refractory: a case report	5
Successful treatment of severe lung cancer caused by third-generation EGFR-TKI resistance due to EGFR genotype conversion with afatinib plus anlotinib	5
The efficacy and safety of adding anlotinib in gradual progression on third-generation EGFR-TKIs for EGFR-mutant advanced nonsmall cell lung cancer	5
LncRNA PCAT6 activated by SP1 facilitates the progression of breast cancer by the miR-326/LRRC8E axis	5
A case of lung adenocarcinoma with MET∆ex14 mutation regressed after preoperative treatment with savolitinib, and successfully underwent radical resection	5
Inhibition of MNK pathway sensitizes nasopharyngeal carcinoma to radiotherapy	5
Comparison of effects of tamoxifen and Toremifene on hepatic function and serum lipids in breast cancer patients during adjuvant endocrine therapy	5
DEPDC1 affects autophagy-dependent glycolysis levels in human osteosarcoma cells by modulating RAS/ERK signaling through TTK	5
Reply to: Association between nilotinib-induced hyperbilirubinemia and UGT1A1 polymorphisms in a chronic myeloid leukemia patient	5
Inhibition of nuclear receptor coactivator 5 overcomes acquired lenvatinib resistance driven by protein kinase B-mammalian target of rapamycin signaling in hepatocellular carcinoma	5
Efficacy and safety of anlotinib as maintenance therapy after induction chemotherapy in extensive-stage small-cell lung cancer	5
Propranolol suppresses infantile hemangioma cell proliferation and promotes apoptosis by upregulating miR-125b expression: Retraction	5