Human & Experimental Toxicology

Papers
(The TQCC of Human & Experimental Toxicology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)
ArticleCitations
RETRACTED: AgNPs reduce reproductive capability of female mouse for their toxic effects on mouse early embryo development52
Effects of larazotide acetate, a tight junction regulator, on the liver and intestinal damage in acute liver failure in rats45
Long non-coding RNA LINC00630 facilitates hepatocellular carcinoma progression through recruiting transcription factor E2F1 to up-regulate cyclin-dependent kinase 2 expression41
Synergistic effects of sinapic acid and ellagic acid ameliorate streptozotocin-induced diabetic nephropathy by inhibiting apoptosis, DNA damage, and structural deterioration in rats39
Circ_0006220 promotes non-small cell lung cancer progression via sponging miR-203-3p and regulating RGS17 expression38
Gallic acid protects against isoproterenol-induced cardiotoxicity in rats38
Sevoflurane preconditioning attenuates myocardial cell damage caused by hypoxia and reoxygenation via regulating the NORAD/miR-144-3p axis37
Resolvin D1 protects against cadmium chloride-induced memory loss and hippocampal damage in rats: A comparison with docosahexaenoic acid34
Effect of nano zinc oxide on proliferation and toxicity of human gingival cells31
Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma29
LINC00641 impeded the malignant biological behaviors of papillary thyroid carcinoma cells via interacting with IGF2BP1 to reduce GLI1 mRNA stability29
Prenatal and early life lead exposure induced neurotoxicity29
Neutrophil-to-lymphocyte ratio versus platelet-to-lymphocyte ratio in predicting clinical outcomes in acute methanol poisoning27
Oxidative stress reactions in rats with pulmonary injuries induced by sulfur mustard (1 LD50)26
Development and validation of a novel poisoning agitation-sedation score for predicting the need for endotracheal intubation and mechanical ventilation in acutely poisoned patients with disturbed cons23
Protective effects of necrostatin-1 on doxorubicin-induced cardiotoxicity in rat heart23
Modulation of NRF2/ARE pathway- and cell death-related genes during drug-induced liver injury23
Exploring the utility of zinc finger protein-related genes in predicting hepatocellular carcinoma prognosis, immune responses, and drug efficacy22
Retraction Notice: “Sulforaphane triggers iron overload-mediated ferroptosis in gastric carcinoma cells by activating the PI3K/IRP2/DMT1 pathway”21
Taraxasterol attenuates melanoma progression via inactivation of reactive oxygen species-mediated PI3K/Akt signaling pathway20
RETRACTED: Neuroprotective effects of tannic acid against kainic acid-induced seizures in mice20
The protective role of curcumin against toxic effect of nonylphenol on bone development20
LINC00294/miR-620/MKRN2 axis provides biomarkers and negatively regulates malignant progression in colorectal carcinoma20
Clerodane diterpene induces apoptosis/anoikis and suppresses migration and invasion of human bladder cancer cells through the histone deacetylases, integrin–focal adhesion kinase, and matrix metallopr19
Curculigoside mitigates hepatic ischemia/reperfusion-induced oxidative stress, inflammation, and apoptosis via activation of the Nrf-2/HO-1 pathway19
Effects of doxorubicin on autophagy in fibroblasts18
RETRACTION NOTICE: Cytochrome P450 3A5 polymorphism affects the metabolism of sorafenib and its toxicity for hepatocellular carcinoma cells in vitro18
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis18
Methamphetamine exposure increases cardiac microvascular permeability by activating the VEGF-PI3K-Akt-eNOS signaling pathway, reversed by Bevacizumab18
Effects of methylphenidate on femoral bone growth in male rats17
Parkinson’s disease protein 7 protected against oxidative stress of myocardial infarction direct through p47phox and nicotinamide adenine dinucleotide phosphate oxidase 417
Retraction Notice17
MicroRNA-200b-3p as a biomarker for diagnosis and survival prognosis of multiple organ dysfunction syndrome caused by acute paraquat poisoning16
Evaluation of the toxic effects of thimerosal and/or aluminum hydroxide in SH-SY5Y cell line16
Preliminary safety assessment of CIGB-210, an investigational peptide for HIV infection15
Effects of polycyclic aromatic hydrocarbon exposure on mitochondrial DNA copy number15
Vinpocetine attenuates fluoxetine-induced liver damage in rats; Role of Nrf2 and PPAR-γ15
Exosomes derived from M2 macrophages promote fibroblast autophagy to contribute to hypertrophic scar formation via CXCL2/CXCR7/mTOR pathway15
Withania somnifera (Ashwagandha) root extract counteract acute and chronic impact of γ-radiation on liver and spleen of rats15
Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders15
Solasonine relieves sevoflurane-induced neurotoxicity via activating the AMP-activated protein kinase/FoxO3a pathway15
Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice15
Hyperoside exerts protective effects against anticardiolipin antibody-induced recurrent pregnancy loss in vivo and in vitro15
Lipid emulsion attenuates propranolol-induced early apoptosis in rat cardiomyoblasts15
Aluminum chloride induces G0/G1 phase arrest via regulating the reactive oxygen species-depended non-canonical STAT1 pathway in hFOB1.19 cells15
Resveratrol reverses the cadmium-promoted migration, invasion, and epithelial–mesenchymal transition procession by regulating the expression of ZEB114
Notoginsenoside R1 protects hypoxia-reoxygenation deprivation-induced injury by upregulation of miR-132 in H9c2 cells14
NAMPT-mediated NAD+ biosynthesis suppresses activation of hepatic stellate cells and protects against CCl4-induced liver fibrosis in mice14
MicroRNA-122-5p prevents proliferation and promotes apoptosis of hepatic stellate cells by suppressing the cellular-Abelsongene/histone deacetylases 2 pathway14
Salidroside attenuates LPS-induced kidney injury through activation of SIRT1/Nrf2 pathway14
Ginsenoside Rg5 induces NSCLC cell apoptosis and autophagy through PI3K/Akt/mTOR signaling pathway14
Hypoxic preconditioning neural stem cell transplantation promotes spinal cord injury in rats by affecting transmembrane immunoglobulin domain-containing13
Baicalein exerts beneficial effects in lipopolysaccharide-induced pulmonary inflammation by modulating macrophage polarization and inhibiting pyroptosis13
Clinical characteristics and the risk factors analysis in patients with delayed encephalopathy after acute carbon monoxide poisoning13
CircRNA_001373 promotes liver fibrosis by regulating autophagy activation in hepatic stellate cells via the miR-142a-5p/Becn1 axis13
Oxidative stress and biochemical indicators in blood of patients addicted to alcohol treated for acute ethylene glycol poisoning13
Relationship between clock gene expression and CYP2C19 and CYP3A4 with benzodiazepines13
Retrospective analysis of the etiology and drugs for vitreous hemorrhage caused by non-diabetic retinopathy and non-traumatic factors13
Retraction notice: “3,4-Methylenedioxymethamphetamine causes retinal damage in C57BL/6J mice”13
Protective effects of butylated hydroxytoluene on the initiation of N-nitrosodiethylamine-induced hepatocellular carcinoma in albino rats13
Ginkgolic acid induces apoptosis and autophagy of endometrial carcinoma cells via inhibiting PI3K/Akt/mTOR pathway in vivo and in vitro13
The possible cytotoxicity and genotoxicity assessment of indaziflam on HepG2 cells12
Chrysin alleviates alteration of bone-remodeling markers in ovariectomized rats and exhibits estrogen-like activity in silico12
TLR4/ MyD88/NF-κB signaling pathway involved in the protective effect of diacerein against lung fibrosis in rats12
Dapansutrile ameliorated chondrocyte inflammation and osteoarthritis through suppression of MAPK signaling pathway12
Overcoming chemoresistance in glioblastoma by fluvastatin via prenylation-dependent inhibition of Ras signaling12
Mycotoxin ingestion during late gestation alters placentome structure, cotyledon transcriptome, and fetal development in pregnant sheep12
RETRACTED: Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway12
Activation of SIRT3/AMPK/mTOR-mediated autophagy promotes quercetin-induced ferroptosis in oral squamous cell carcinoma12
Antidiabetic effects of nerolidol through promoting insulin receptor signaling in high-fat diet and low dose streptozotocin-induced type 2 diabetic rats11
Retraction: Association of miR-9-5p and NFIC in the progression of gastric cancer11
Effect of lipid emulsion on acute clozapine poisoning-induced QT prolongation11
Silymarin protects the rats against paraquat-induced acute kidney injury via Nrf211
Betalain exerts cardioprotective and anti-inflammatory effects against the experimental model of heart failure11
The effect of melatonin on capecitabine-induced hepatic and renal toxicity in rats11
Anlotinib induces apoptosis and second growth/mitosis phase block in cisplatin-resistant ovarian cancer cells via the aurora kinase A/p53 pathway11
Carvedilol alleviates the detrimental effects of azathioprine on hepatic tissues in experimental rats: Focusing on redox system, inflammatory and apoptosis pathways11
Gallic acid ameliorates di-(2-ethylhexyl) phthalate-induced testicular injury in adult mice10
Propofol suppresses proliferation, migration, invasion, and tumor growth of liver cancer cells via suppressing cancer susceptibility candidate 9/phosphatase and tensin homolog/AKT serine/threonine kin10
Pulmonary toxicity of sodium dichloroisocyanurate after intratracheal instillation in sprague-dawley rats10
MiR-3612 targeting THBS1 suppresses nasopharyngeal carcinoma progression by PI3K/AKT signaling pathway10
Retraction notice: “Long noncoding RNA SNHG14 regulates ox-LDL-induced atherosclerosis cell proliferation and apoptosis by targeting miR-186-5p/WIPF2 axis”10
Assessment of the cellular integrity and expression of melatonin receptor (MTNR1A) in the retina assaulted by ethanol and acetaminophen10
Cysteine-rich 61(CYR61) alleviates cyclophosphamide-induced proliferation inhibition in ovarian granulosa cells via suppressing NLRP3/caspase1-mediated pyroptosis10
The sesquiterpenoid valerenic acid protects neuronal cells from the detrimental effects of the fungicide benomyl on apoptosis and DNA oxidation10
RETRACTED: Cytochrome P450 3A5 polymorphism affects the metabolism of sorafenib and its toxicity for hepatocellular carcinoma cells in vitro10
Scutellarin alleviates type 2 diabetes (HFD/low dose STZ)-induced cardiac injury through modulation of oxidative stress, inflammation, apoptosis and fibrosis in mice9
A review of challenges and prospects of 3D cell-based culture models used for studying drug induced liver injury during early phases of drug development9
Prognostic factors of acetaminophen exposure in the United States: An analysis of 39,000 patients9
Curcumin alleviated lipopolysaccharide-evoked H9c2 cells damage via suppression of intercellular adhesion molecule 1/CD40/NF-κB signaling9
MAPK-interacting kinases inhibition by eFT508 overcomes chemoresistance in preclinical model of osteosarcoma9
Cigarette smoking extract induces mitochondrial dysfunction and apoptosis in HUVECs via the Sirt1-SHH axis9
Overexpression of lncRNA A2M-AS1 inhibits cell growth and aggressiveness via regulating the miR-587/bone morphogenetic protein 3 axis in lung adenocarcinoma9
Assessment of safety through mutagenicity and subchronic toxicity studies with black pepper extract preparation9
LINC00265 promotes the viability, proliferation, and migration of bladder cancer cells via the miR-4677-3p/FGF6 axis9
Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway9
Anti-oxidative properties of nanocrocin in Zearalenone induced toxicity on Hek293 cell; The novel formulation and cellular assessment9
Trimethylamine-N oxide enhances post-stroke depression progression via ROS-p38/MAPK signaling9
Diagnostic and prognostic value of diquat plasma concentration and complete blood count in patients with acute diquat poisoning based on random forest algorithms9
Down-regulation of E2F1 attenuates UVB-induced human lens epithelial cell oxidative stress and pyroptosis through inhibiting NLRP38
Persistent diazinon induced neurotoxicity: The effect on inhibitory avoidance memory performance, amyloid precursor proteins, and TNF-α levels in the prefrontal cortex of rats8
RETRACTED: Association of miR-9-5p and NFIC in the progression of gastric cancer8
Emodin protects against apoptosis and inflammation by regulating reactive oxygen species-mediated NF-κB signaling in interleukin‐1β-stimulated human nucleus pulposus cells8
Downregulation of miR-138-5p alleviates propofol-induced neurotoxicity and autophagy by regulating SIRT18
Evaluation of the effectiveness of fresh frozen plasma transfusion as adjuvant treatment in acute organophosphate-poisoned patients: A randomized clinical trial8
Anti-EMT properties of ergothioneine attenuate lipopolysaccharide-induced oxidative stress-mediated acute lung injury via modulating TGF-β/smad/snail signaling pathway8
Curcumin treatment attenuates cisplatin-induced gastric mucosal inflammation and apoptosis through the NF- κ B and MAPKs signaling pathway8
Environmental contaminants, endocrine disruption, and transgender: Can “born that way” in some cases be toxicologically real?8
Implication of microglia in ketamine-induced long-term cognitive impairment in murine pups8
Exosome-derived miR-2682-5p suppresses cell viability and migration by HDAC1-silence-mediated upregulation of ADH1A in non-small cell lung cancer8
Protective effects of brain and muscle ARNT-like gene 1 on oxidized low-density lipoprotein-induced human brain microvascular endothelial cell injury by alleviating ferroptosis8
Increased FGFR3 is involved in T-2 toxin-induced lesions of hypertrophic cartilage associated with endemic osteoarthritis8
Retraction Notice7
Nomogram for predicting mechanical ventilation need among acutely intoxicated patients with impaired consciousness: Correspondence7
Androgen receptor suppresses inflammatory response of airway epithelial cells in allergic asthma through MAPK1 and MAPK147
An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species7
Antagonism of G protein-coupled receptor 55 prevents lipopolysaccharide-induced damages in human dental pulp cells7
Discovering the most impactful treatments for aluminum phosphide cardiotoxicity gleaned from systematic review of animal studies7
Resveratrol and lycopene ameliorate contrast-induced nephropathy in a rabbit model7
The influence of PM2.5 exposure on kidney diseases7
Cathepsin B mediates the lysosomal-mitochondrial apoptosis pathway in arsenic-induced microglial cell injury7
Subchronic inhalation of a novel electronic nicotine delivery system formulation and its corresponding base formulation7
Potential anticancer effect of sodium caprate on human gastric cancer cells7
Establishment of an animal model of sciatic nerve injury induced by local anesthetics7
Ginsenoside Re suppresses high glucose-induced apoptosis of placental trophoblasts through endoplasmic reticulum stress-related CHOP/GADD1537
Renal glucose transporters play a role in removal of cadmium from kidney cells mediated by GMDTC – A novel metal chelator7
Tricin attenuates diabetic retinopathy by inhibiting oxidative stress and angiogenesis through regulating Sestrin2/Nrf2 signaling7
Verbascoside represses malignant phenotypes of esophageal squamous cell carcinoma cells by inhibiting CDC42 via the HMGB1/RAGE axis7
Neurologic disease produced by Rathayibacter toxicus-derived corynetoxins7
Neuroprotective potential of nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element signaling modulator cucurbitacin I upon glucose and oxygen deprivation/reperfusion (OGD/RP)7
Rhamnazin ameliorates 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-evoked testicular toxicity by restoring biochemical, spermatogenic and histological profile in male albino rats7
CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer7
Hypoxia-induced autophagy attenuates ferredoxin 1-mediated cuproptosis in colorectal cancer cells7
Retraction Notice7
RETRACTED: Sulforaphane triggers iron overload-mediated ferroptosis in gastric carcinoma cells by activating the PI3K/IRP2/DMT1 pathway7
Erythropoietin alleviates acute lung injury induced by ischemia-reperfusion through blocking p38 MAPK signaling7
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