Human & Experimental Toxicology

Article	Citations
Luteolin attenuates doxorubicin-induced derangements of liver and kidney by reducing oxidative and inflammatory stress to suppress apoptosis	41
RETRACTED: Exosomes derived from mmu_circ_0000623-modified ADSCs prevent liver fibrosis via activating autophagy	38
Vinpocetine attenuates thioacetamide-induced liver fibrosis in rats	37
Crocin attenuates CCl4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats	33
Bone marrow mesenchymal stem cells-derived exosomes reduce apoptosis and inflammatory response during spinal cord injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway	30
Nobiletin ameliorates nonylphenol-induced testicular damage by improving biochemical, steroidogenic, hormonal, spermatogenic, apoptotic and histological profile	29
Smo-Shh signaling activator purmorphamine ameliorates neurobehavioral, molecular, and morphological alterations in an intracerebroventricular propionic acid-induced experimental model of autism	28
An approach to evaluating the potential teratogenic and neurotoxic mechanism of BHA based on apoptosis induced by oxidative stress in zebrafish embryo (Danio rerio)	28
Investigation of the anti-inflammatory effects of caffeic acid phenethyl ester in a model of λ-Carrageenan–induced paw edema in rats	26
Protective effects of apigenin on methylmercury-induced behavioral/neurochemical abnormalities and neurotoxicity in rats	25
Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside	25
Efficacy ofCoccinia grandisagainst monosodium glutamate induced hepato-cardiac anomalies by inhibiting NF-kB and caspase 3 mediated signalling in rat model	24
The effects of ellagic acid and other pomegranate (Punica granatum L.) derivatives on human gastric cancer AGS cells	23
MicroRNA: Potential biomarker and target of therapy in acute lung injury	23
Thymoquinone is a protective agent that reduces the negative effects of doxorubicin in rat testis	23
Arsenic exposure and non-carcinogenic health effects	22
Protective effect of alpha-pinene against isoproterenol-induced myocardial infarction through NF-κB signaling pathway	22
Synergistic antioxidant capacities of vanillin and chitosan nanoparticles against reactive oxygen species, hepatotoxicity, and genotoxicity induced by aging in male Wistar rats	21
Effect of curcumin on lung epithelial injury and ferroptosis induced by cigarette smoke	21
The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats	21
Synthesis of PEGylated nanographene oxide as a nanocarrier for docetaxel drugs and anticancer activity on prostate cancer cell lines	20
The cross-talk of NLRP3 inflammasome activation and necroptotic hepatocyte death in acetaminophen-induced mice acute liver injury	19
Apigenin alleviates methotrexate-induced liver and kidney injury in mice	18
Sildenafil ameliorates Alzheimer disease via the modulation of vascular endothelial growth factor and vascular cell adhesion molecule-1 in rats	18
Induction of cell cycle arrest and apoptosis by tomentosin in hepatocellular carcinoma HepG2 and Huh7 cells	17

Phillyrin ameliorates diabetic nephropathy through the PI3K/Akt/GSK-3β signalling pathway in streptozotocin-induced diabetic mice	17
The influence of PM2.5 exposure on kidney diseases	17
Circular RNA has circ 0001591 promoted cell proliferation and metastasis of human melanoma via ROCK1/PI3K/AKT by targeting miR-431-5p	17
Effect of nano zinc oxide on proliferation and toxicity of human gingival cells	17
Early intervention with probiotics and metformin alleviates liver injury in NAFLD rats via targeting gut microbiota dysbiosis and p-AKT/mTOR/LC-3II pathways	16
Anti-inflammatory and anti-apoptotic effect of zingiberene on isoproterenol-induced myocardial infarction in experimental animals	16
Protective effects of quercetin and crocin in the kidneys and liver of obese Sprague-Dawley rats with Type 2 diabetes: Effects of quercetin and crocin on T2DM rats	16
Induction of apoptosis in indole-3-carbinol-treated lung cancer H1299 cells via ROS level elevation	16
Quercetin suppresses cell survival and invasion in oral squamous cell carcinoma via the miR-1254/CD36 cascade in vitro	15
Morroniside suppresses hydrogen peroxide-stimulated autophagy and apoptosis in rat ovarian granulosa cells through the PI3K/AKT/mTOR pathway	15
Effect of co-treatment with doxorubicin and verapamil loaded into chitosan nanoparticles on diethylnitrosamine-induced hepatocellular carcinoma in mice	15
Alamandine significantly reduces doxorubicin-induced cardiotoxicity in rats	15
Exosomal miR-455-3p from BMMSCs prevents cardiac ischemia-reperfusion injury	15
Monosodium glutamate causes hepato-cardiac derangement in male rats	15
Scutellarin alleviates type 2 diabetes (HFD/low dose STZ)-induced cardiac injury through modulation of oxidative stress, inflammation, apoptosis and fibrosis in mice	15
Modulation of cigarette smoke extract-induced human bronchial epithelial damage by eucalyptol and curcumin	14
Intravenous lipid emulsion as an adjuvant therapy of acute clozapine poisoning	14
Icariin inhibits gastric cancer cell growth by regulating the hsa_circ_0003159/miR-223-3p/NLRP3 signaling axis	14
Ocular toxicity assessment of nanoemulsion in-situ gel formulation of fluconazole	14
Coenzyme Q10 ameliorates inflammation, oxidative stress, and testicular histopathology in rats exposed to heat stress	14
Dendrobine attenuates isoniazid- and rifampicin-induced liver injury by inhibiting miR-295-5p	14
Quercetin inhibited the proliferation and invasion of hepatoblastoma cells through facilitating SIRT6-medicated FZD4 silence	14
RETRACTED: LncRNA OTUD6B-AS1 inhibits many cellular processes in colorectal cancer by sponging miR-21-5p and regulating PNRC2	14
Proteasome inhibitor MG132 induces apoptosis in human osteosarcoma U2OS cells	13
Silencing lncRNA HCG18 regulates GPX4-inhibited ferroptosis by adsorbing miR-450b-5p to avert sorafenib resistance in hepatocellular carcinoma	13
Synthetic cathinone poisoning from ingestion of drug-laced “instant coffee packets” in Taiwan	13
Altered expressions of circulating microRNAs 122 and 192 during antitubercular drug induced liver injury indicating their role as potential biomarkers	13
Role of TLR-4/IL-6/TNF-α, COX-II and eNOS/iNOS pathways in the impact of carvedilol against hepatic ischemia reperfusion injury	13
Apelin-13 protects the lungs from ischemia-reperfusion injury by attenuating inflammatory and oxidative stress	13
Toxicity, mutagenicity and stability assessment of simply produced electrolyzed water as a wound healing agent in vitro	12
RETRACTED: MicroRNA-155 is upregulated in the placentas of patients with preeclampsia and affects trophoblast apoptosis by targeting SHH/GLi1/BCL2	12
Sestrin2 protects against traumatic brain injury by reinforcing the activation of Nrf2 signaling	12
Alpha-lipoic acid alleviates colistin nephrotoxicity in rats	12
Assessment of serum glucose/potassium ratio as a predictor for delayed neuropsychiatric syndrome of carbon monoxide poisoning	12
The PAD4 inhibitor GSK484 enhances the radiosensitivity of triple-negative breast cancer	12
Lobetyolin inhibits the proliferation of breast cancer cells via ASCT2 down-regulation-induced apoptosis	12
Stereological and histopathological evaluation of doxorubicin-induced toxicity in female rats’ ovary and uterus and palliative effects of quercetin and vitamin E	12
FOXM1 regulates the proliferation, apoptosis and inflammatory response of keratinocytes through the NF-κB signaling pathway	11
Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway	11
Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2	11
Investigation of DNA damage, oxidative stress, and inflammation in synthetic cannabinoid users	11
Role of inhibiting Chk1-p53 pathway in hepatotoxicity caused by chronic arsenic exposure from coal-burning	11
Gastrodin protects against high glucose-induced cardiomyocyte toxicity via GSK-3β-mediated nuclear translocation of Nrf2	11
Gene expression profiles of transient receptor potential (TRP) channels in the peripheral blood mononuclear cells of psoriasis patients	11
Electronic cigarette liquid substances propylene glycol and vegetable glycerin induce an inflammatory response in gingival epithelial cells	11
Role of nitric oxide donor in methotrexate-induced testicular injury via modulation of pro-inflammatory mediators, eNOS and P-glycoprotein	11
Uremic solutes of indoxyl sulfate and p-cresol enhance protease-activated receptor-2 expression in vitro and in vivo in keratinocytes	11
Machine learning algorithms to predict seizure due to acute tramadol poisoning	11
Antimalarial agent artesunate induces G0/G1 cell cycle arrest and apoptosis via increasing intracellular ROS levels in normal liver cells	11
RETRACTED: LncRNA MIAT regulated by selenium and T-2 toxin increases NF-κB-p65 activation, promoting the progress of Kashin-Beck Disease	11

Effect of curcumin on the non-alcoholic steatohepatitis via inhibiting the M1 polarization of macrophages	11
Solasonine relieves sevoflurane-induced neurotoxicity via activating the AMP-activated protein kinase/FoxO3a pathway	10
Modulation of NRF2/ARE pathway- and cell death-related genes during drug-induced liver injury	10
Renoprotective effects of prazosin on ischemia-reperfusion injury in rats	10
Exosome-derived miR-2682-5p suppresses cell viability and migration by HDAC1-silence-mediated upregulation of ADH1A in non-small cell lung cancer	10
Pyrvinium pamoate induces in-vitro suppression of IL-6 and IL-8 produced by human endometriotic stromal cells	10
Gallic acid protects against isoproterenol-induced cardiotoxicity in rats	10
RETRACTED: Heat shock protein 70 expression protects against sepsis-associated cardiomyopathy by inhibiting autophagy	10
Notoginsenoside R1 protects hypoxia-reoxygenation deprivation-induced injury by upregulation of miR-132 in H9c2 cells	10
LncRNA PART1 promotes lung squamous cell carcinoma progression via miR-185-5p/Six1 axis	10
Glycyrrhizic acid ameliorates sodium nitrite-induced lung and salivary gland toxicity: Impact on oxidative stress, inflammation and fibrosis	10
Synergistic effects of sinapic acid and ellagic acid ameliorate streptozotocin-induced diabetic nephropathy by inhibiting apoptosis, DNA damage, and structural deterioration in rats	10
Epicatechin ameliorative effects on methotrexate-induced hepatotoxicity in mice	10
EGFR tyrosine kinase inhibitor Almonertinib induces apoptosis and autophagy mediated by reactive oxygen species in non-small cell lung cancer cells	10
Upregulated miR-101 inhibits acute kidney injury–chronic kidney disease transition by regulating epithelial–mesenchymal transition	10
Subacute melamine exposure disrupts task-based hippocampal information flow via inhibiting the subunits 2 and 3 of AMPA glutamate receptors expression	10
Melatonin decreases metastasis, primary tumor growth and angiogenesis in a mice model of breast cancer	10
The role of ferroptosis in organ toxicity	10
Triptolide regulates oxidative stress and inflammation leading to hepatotoxicity via inducing CYP2E1	9
Lysine-specific demethylase 1 induced epithelial–mesenchymal transition and promoted renal fibrosis through Jagged-1/Notch signaling pathway	9
A comparative assessment of e-cigarette aerosol extracts and tobacco cigarette smoke extracts on in vitro endothelial cell inflammation response	9
Metformin protects against diabetes-induced heart injury and dunning prostate cancer model	9
Resveratrol prevents acute renal injury in a model of ruptured abdominal aortic aneurysm	9
MiR-32-5p knockdown inhibits epithelial to mesenchymal transition and renal fibrosis by targeting SMAD7 in diabetic nephropathy	9
MDM2 inhibition improves cisplatin-induced renal injury in mice via inactivation of Notch/hes1 signaling pathway	9
Arsenic trioxide-induced cardiotoxicity triggers ferroptosis in cardiomyoblast cells	9
Ephedrine attenuates cerebral ischemia/reperfusion injury in rats through NF-κB signaling pathway	9
CTRP3 protects hippocampal neurons from oxygen-glucose deprivation-induced injury through the AMPK/Nrf2/ARE pathway	9
Betalain exerts cardioprotective and anti-inflammatory effects against the experimental model of heart failure	9
Ephedrine ameliorates cerebral ischemia injury via inhibiting NOD-like receptor pyrin domain 3 inflammasome activation through the Akt/GSK3β/NRF2 pathway	9
Long non-coding RNA SNHG16, binding with miR-106b-5p, promoted cell apoptosis and inflammation in allergic rhinitis by up-regulating leukemia inhibitory factor to activate the JAK1/STAT3 signaling pat	9
Ropivacaine represses the ovarian cancer cell stemness and facilitates cell ferroptosis through inactivating the PI3K/AKT signaling pathway	9
MicroRNA-26b-5p alleviates cerebral ischemia-reperfusion injury in rats via inhibiting the N-myc/PTEN axis by downregulating KLF10 expression	9
In vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavone	9
Synthesis of N,N′-bis(1,5-dimethyl-2-phenyl-1,2-dihydro-3-oxopyrazol-4-yl) sebacamide that ameliorate osteoarthritis symptoms and improve bone marrow matrix structure and cartilage alter	9
Protective effect of pyrrolidine dithiocarbamate against methotrexate-induced testicular damage	9
Rhamnetin alleviates polystyrene microplastics-induced testicular damage by restoring biochemical, steroidogenic, hormonal, apoptotic, inflammatory, spermatogenic and histological profile in male albi	9
MiR-663a, regulated by lncRNA GAS5, contributes to osteosarcoma development through targeting MYL9	8
RETRACTED: Long noncoding RNA SNHG14 regulates ox-LDL-induced atherosclerosis cell proliferation and apoptosis by targeting miR-186-5p/WIPF2 axis	8
Protective effect of Coenzyme Q10 on oxidative ovarian and uterine damage induced by methotrexate in rats	8
Melatonin attenuates chemical-induced cardiotoxicity	8
MiR-200c-3p regulates pyroptosis by targeting SLC30A7 in diabetic retinopathy	8
Comparative toxicity assessment of nano- and bulk-phase titanium dioxide particles on the human mammary gland in vitro	8
LINC00265 promotes the viability, proliferation, and migration of bladder cancer cells via the miR-4677-3p/FGF6 axis	8
Effect of taxifolin/dapagliflozin combination on colistin-induced nephrotoxicity in rats	8
Acetaminophen alleviates ferroptosis in mice with sepsis-associated encephalopathy via the GPX4 pathway	8
Assessment of oxidative DNA damage, oxidative stress responses and histopathological alterations in gill and liver tissues of Oncorhynchus mykiss treated with linuron	8
Ginkgolic acid induces apoptosis and autophagy of endometrial carcinoma cells via inhibiting PI3K/Akt/mTOR pathway in vivo and in vitro	8
Tricin attenuates cerebral ischemia/reperfusion injury through inhibiting nerve cell autophagy, apoptosis and inflammation by regulating the PI3K/Akt pathway	8
Perinatal exposure to di-(2-ethylhexyl) phthalate induces hepatic lipid accumulation mediated by diacylglycerol acyltransferase 1	8
Tricin attenuates diabetic retinopathy by inhibiting oxidative stress and angiogenesis through regulating Sestrin2/Nrf2 signaling	8
Effects of butein on human osteosarcoma cell proliferation, apoptosis, and autophagy through oxidative stress	8
Mitigation of IL-1β, IL-6, TNF-α, and markers of apoptosis by ursolic acid against cisplatin-induced oxidative stress and nephrotoxicity in rats	8
Chemopreventive effect of galangin against benzo(a)pyrene-induced stomach tumorigenesis through modulating aryl hydrocarbon receptor in Swiss albino mice	8
Thymoquinone supplementation ameliorates cisplatin-induced hepatic pathophysiology	8
(Z)-7,4′-Dimethoxy-6-hydroxy-aurone- 4-O-β-glucopyranoside alleviates cerebral ischemia-reperfusion injury in rats associating with the regulation of JAK1/STAT1 signaling pathway	8
Metabolic profiling of 19 amino acids in triptolide-induced liver injured rats by gas chromatography-triple quadrupole mass spectrometry	8
RETRACTED: Curcumin and resveratrol inhibit chemoresistance in cisplatin-resistant epithelial ovarian cancer cells via targeting P13K pathway	8
Carvacrol hinders the progression of hepatic fibrosis via targeting autotaxin and thioredoxin in thioacetamide-induced liver fibrosis in rat	8
MiR-655-3p inhibits the progression of osteoporosis by targeting LSD1 and activating BMP-2/Smad signaling pathway	7
Arbutin prevents alterations in mitochondrial and lysosomal enzymes in isoproterenol-induced myocardial infarction: An in vivo study	7
Exposure to a “safe” dose of environmental pollutant bisphenol A elevates oxidative stress and modulates vasoactive system in hypertensive rats	7
Ephedrine causes liver toxicity in SD rats via oxidative stress and inflammatory responses	7
In vivo assessment of the toxicity of electronic cigarettes to zebrafish (Danio rerio) embryos, following gestational exposure, in terms of mortality, developmental toxicity, and hair ce	7
Protective effects of zingerone on high cholesterol diet-induced atherosclerosis through lipid regulatory signaling pathway	7
Taraxasterol inhibits TGF-β1-induced epithelial-to-mesenchymal transition in papillary thyroid cancer cells through regulating the Wnt/β-catenin signaling	7
Organ function, sphingolipid levels and inflammation in tunicamycin induced endoplasmic reticulum stress in male rats	7
Taraxasterol attenuates melanoma progression via inactivation of reactive oxygen species-mediated PI3K/Akt signaling pathway	7
miR-146a alleviates the apoptosis of hippocampal neurons induced by microglia activation via targeting TRAF6	7
Dental amalgam fillings and mercury vapor safety limits in American adults	7
Resolvin D1 protects against cadmium chloride-induced memory loss and hippocampal damage in rats: A comparison with docosahexaenoic acid	7
Lipid emulsion attenuates extrinsic apoptosis induced by amlodipine toxicity in rat cardiomyoblasts	7
Hepatoprotective effect of ferulic acid and/or low doses of γ-irradiation against cisplatin-induced liver injury in rats	7
Comparing the effectiveness of L-carnitine and paraffin oil in acute aluminum phosphide poisoning using predictive biomarkers and scores: A randomized controlled clinical trial	7
Inorganic arsenic administration suppresses human neutrophil function in vitro	7
Knockdown of TRIM24 suppresses growth and induces apoptosis in acute myeloid leukemia through downregulation of Wnt/GSK-3β/β-catenin signaling	7
Heavy metal and essential elements in beers from turkey market: A risk assessment study	7
Neurodevelopmental toxicity induced by PM2.5 Exposure and its possible role in Neurodegenerative and mental disorders	7
Toxic mechanisms of cadmium and exposure as a risk factor for oral and gastrointestinal carcinomas	7
Hepatoprotective effect of Omega-3 PUFAs against acute paracetamol-induced hepatic injury confirmed by FTIR	7

Oxymatrine attenuates TNBS-induced colinutis in rats through TLR9/Myd88/NF-κB signal pathway	7
Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary	7
Dexamethasone and losartan combination treatment protected cigarette smoke-induced COPD in rats	7
Hexagonal boron nitride nanoparticles trigger oxidative stress by modulating thiol/disulfide homeostasis	7
Kaempferol ameliorates palmitate-induced lipid accumulation in HepG2 cells through activation of the Nrf2 signaling pathway	7
Protective effect of D-(−)-quinic acid as food supplement in modulating AMP-activated protein kinase signalling pathway activation in HFD induced obesity	7
Thymoquinone ameliorates bleomycin-induced reproductive toxicity in male Balb/c mice	7
Paraoxonase 2 protects against oxygen-glucose deprivation/reoxygenation-induced neuronal injury by enhancing Nrf2 activation via GSK-3β modulation	7
The effect of baicalein on endoplasmic reticulum stress and autophagy on liver damage	7
Molecular perspective concerning fluoride and arsenic mediated disorders on epididymal maturation of spermatozoa: A concise review	7
The effects of subconjunctival bevacizumab, ranibizumab, and aflibercept on corneal neovascularization	7
Protective effects of Gamma Oryzanol on distant organs after kidney ischemia-reperfusion in rats: A focus on liver protection	7