OOIR: Observatory of International Research

Papers

(The H4-Index of Bioorganic & Medicinal Chemistry Letters is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The SARS-CoV-2 main protease as drug target	538
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir	126
Pyridones in drug discovery: Recent advances	70
The relationship between the structure and toxicity of aminoglycoside antibiotics	63
Structural hybridization as a facile approach to new drug candidates	60
Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents	58
Recent advances in antibacterial agents	53
New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation	52
The expanding reaction toolkit for DNA-encoded libraries	51
Cryo-EM as a powerful tool for drug discovery	49
1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies	48
Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents	47
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study	44
Structure and bioactivity of colibactin	44
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs	41
Discovery and biological evaluation of proteolysis targeting chimeras (PROTACs) as an EGFR degraders based on osimertinib and lenalidomide	37
Synthesis and biological evaluation of anti-tubercular activity of Schiff bases of 2-Amino thiazoles	35
Design, synthesis, biological evaluation and molecular docking of new uracil analogs-1,2,4-oxadiazole hybrids as potential anticancer agents	34
Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax	34
Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus	33
Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition	33
Synthesis and biological evaluation of novel quinazoline-triazole hybrid compounds with potential use in Alzheimer’s disease	33
Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects	32
New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants	32
Novel isoniazid embedded triazole derivatives: Synthesis, antitubercular and antimicrobial activity evaluation	32

New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies	31
Synthesis and anti-proliferative activity of a novel 1,2,3-triazole tethered chalcone acetamide derivatives	31
Novel vanillin derivatives containing a 1,3,4-thiadiazole moiety as potential antibacterial agents	31
Exploring the potential of novel phenolic compounds as potential therapeutic candidates against SARS-CoV-2, using quantum chemistry, molecular docking and dynamic studies	30
Click synthesis of 1,2,3-triazole based imidazoles: Antitubercular evaluation, molecular docking and HSA binding studies	30