Bioorganic & Medicinal Chemistry Letters

Article	Citations
Revisiting the dipeptidyl carboxypeptidase inhibitor captopril as a source of pan anti-trypanosomatid agents	159
Design, synthesis and biological evaluation of alginate oligosaccharide derivatives	92
Design, synthesis and biological evaluation of tanshinone IIA derivatives as NLRP3 inflammasome inhibitors	68
Discovery of DS-1093a: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia	60
Editorial Board	56
Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site	50
Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators	49
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibit	41
Enteroviral replication inhibition by N-Alkyl triazolopyrimidinone derivatives through a non-capsid binding mode	40
Graphical Abstract TOC	37
Editorial Board	35
Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor	33
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads	31
Neuropilin 1-targeted near-infrared fluorescence probes for tumor diagnosis	30
Pyrazolo-1-carbothioamides as EGR-1–DNA binding disruptors	30
Design, synthesis and characterizations of prodrugs of brexanolone	28
Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model	27
Development of a highly potent and selective degrader of LRRK2	26
Phytochemical investigation of Asarum sieboldii var. seoulense and the phenotypic profiles of its constituents against a Parkinson’s Disease olfactory cell line	26
Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor	25
Improved synthesis and anticancer activity of a potent neuronal nitric oxide synthase inhibitor	25
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity	25
Epigallocatechin and epigallocatechin-3-gallate are not inhibitors of tyrosinase	24
Discovery of a macrocyclic FAK inhibitor GZD-257 for treatment of glioblastoma	24
Contents continued	24

A concise review on MDM2 inhibitors and recent progress in radiopharmaceutical development for imaging MDM2 expression in tumors with PET or SPECT	23
Armeniaspirol analogues disrupt the electrical potential (ΔΨ) of the proton motive force	22
Studies on in vitro modulatory effects to base excision repair enzymes induced by small molecule binding to Deaminated CAG repeat hairpin	21
4′-O-methoxyethyl-2′-deoxy-uridine and cytidine ribonucleotides improve duplex stability, nuclease resistance, and elicit efficient knockdown of Bcl-2 expression	21
Green synthesis and anti-biofilm activities of 3,5-disubstituted isoxazoline/isoxazole-linked secondary sulfonamide derivatives on Pseudomonas aeruginosa	21
A fluorescent molecular rotor for the selective detection of the hybrid-conformation 22AG G-Quadruplex	21
Synthesis and biological evaluation of novel 1,2,3,4-tetrahydro-β-carboline derivatives as potential antibacterial agents	21
New class of fused [3,2-b][1,2,4]triazolothiazoles for targeting glioma in vitro	20
A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation	20
New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants	20
Recent progress in synthetic strategies to develop potent, HDAC8-selective, small-molecule inhibitors	20
Design and evaluation of anaplastic lymphoma kinase degraders using a covalent fumarate handle	19
A PSMA-targeted doxorubicin small-molecule drug conjugate	19
Contents continued	19
Design and synthesis of Tetrahydroindeno[4,5-c]chromen-4(3H)-one derivatives as antiproliferative agents for prostate Cancer cells	19
Contents continued	19
Synthesis and evaluation of 3-hydroxyquinolin-2(1H)-one derivatives as inhibitors of tyrosinase	18
Design, synthesis, and evaluation of 1,3,4-oxadiazole-based EGFR inhibitors	18
Contents continued	18
Design and activity evaluation of new EGFR tyrosine kinase inhibitors containing cyclic polyamines	18
Design, synthesis, and biological evaluation of 5ʹ-deoxy (N)-methanocarbanucleoside derivatives as A3 adenosine receptor ligands	17
Discovery and optimization of (2-naphthylthio)acetic acid derivative as selective Bfl-1 inhibitor	17
Comparative analysis of p-terphenylquinone and seriniquinone derivatives as reactive oxygen species-modulating agents	17
Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors	17
α-Fluorination of tropane compounds and its impact on physicochemical and ADME properties	17
Natural products targeting the NF-κB signaling pathway:Potential therapeutic drug candidates	17
Photocrosslinking and capture for the analysis of carbohydrate-dependent interactions	17
Structure-activity relationship study of HIF-2α inhibitors with tricyclic scaffold	16
Discovery of 3-phenyl-1H-5-pyrazolylamides as PLpro inhibitors through virtual screening and structure optimization	16
An overview of cyclopropenone derivatives as promising bioactive molecules	16
Graphical abstract TOC	16
Biocatalytic synthesis and evaluation of antioxidant and antibacterial activities of hydroxyequols	16
PEG-lipid-modified agonistic antibody against tumor necrosis factor receptor family elicits superior apoptosis-inducing activity against human carcinoma	16
11C-labeling of 20(S)-protopanaxadiol, an aglycon of ginsenoside, based on the use of Pd(0)-mediated rapid C-[11C]methylation of boronic precursors	16
Retraction notice to “Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities” [Bioorg. Med. Chem. Lett. 22(9) (2012) 3067–	16
Design, synthesis and properties of peptide inhibitors based on BRCA1856-871	16
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors	15
Exploratory study of oxatomide derivatives with high P2X7 receptor inhibitory activity	15
Graphical abstract TOC	15
Graphical abstract TOC	15
Editorial Board	15
Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity	15
Graphical abstract TOC	15
Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships	15
Ultrasound-dependent RNAi using TatU1A-rose bengal conjugate	14
pH-responsive aggregates consisted of oligodeoxynucleotides bearing nitrophenol group that deliver drugs into acidic cells	14
Biological evaluation of newly synthesized α-benzil monoxime thiocarbohydrazide derivatives as an antimicrobial and anticancer agent: In vitro screening and ADMET predictions	14
Design, synthesis and biological evaluation of novel cyano-cinnamate derivatives as mitochondrial pyruvate carrier inhibitors	14
nTZDpa (non-thiazolidinedione PPARγ partial agonist) derivatives retain antimicrobial activity without improving renal toxicity	14
Graphical abstract TOC	14

Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity	14
Design, synthesis and biological evaluation of pteridine-7(8H)-one derivatives as potent and selective CDK4/6 inhibitors	14
Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor	14
A photoactivatable self-localizing ligand with improved photosensitivity for chemo-optogenetic control of protein localization in living cells	14
DDD-028: A potent, neuroprotective, non-opioid compound for the treatment of diabetic neuropathy	14
Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase	13
Structure-activity relationship of dual inhibitors containing maleimide and imidazole motifs against glutaminyl cyclase and glycogen synthase kinase-3β	13
Rational design, synthesis and biological evaluation of novel HIV-1 protease inhibitors containing 2-phenylacetamide derivatives as P2 ligands with potent activity against DRV-Resistant HIV-1 variants	13
Design, synthesis and biological evaluation of novel procaine derivatives for intravenous anesthesia	13
Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists	13
Pharmacokinetic analysis of 6-O-[18F]FEE for PET imaging of EGFR mutation	13
High-yield and high-purity amide bond formation using DMTMM PF6 for DNA-encoded libraries	13
Synthesis and evaluation of lipoic acid – donepezil hybrids for Alzheimer’s disease using a straightforward strategy	13
Editorial Board	13
Rationalizing the binding and α subtype selectivity of synthesized imidazodiazepines and benzodiazepines at GABAA receptors by using molecular docking studies	12
Graphical abstract TOC	12
Graphical abstract TOC	12
Synthesis of dolutegravir derivatives modified by 1,2,3-triazole structure and their anti-inflammatory activity in LPS-induced BV2 cells	12
Identification of potent and selective inhibitors of PKR via virtual screening and traditional design	12
Graphical abstract TOC	12
Design, synthesis and biological evaluation of cajanonic acid A analogues as potent PPAR γ antagonists	12
Discovery of N-Ts-3-benzylidene-indolin-2-imines as potent anti-colorectal cancer agents through suppression of the PI3K-AKT pathway	12
Phenyl urea based adjuvants for β-lactam antibiotics against methicillin resistant Staphylococcus aureus	12
Graphical abstract TOC	12
Editorial Board	12
(E)-3-(3-([1,1′-Biphenyl]-4-yl)-1-phenyl-1H-pyrazol-4-yl)-1-phenylprop-2-en-1-ones inducing reactive oxygen species generation through glutathione depletion	12
Design, synthesis, and antitumor activity study of novel oleanolic acid structural derivatives targeting c-Kit	12
Neratinib derivative 7A induces apoptosis in colon cancer cells via the p53 pathway	12
Contents continued	12
Reinvestigation of clopidogrel bioactivation unveils new cytochrome P450-catalyzed thioester cleavage mechanism	12
Graphical abstract TOC	12
Structure–activity relationship of 2-aminodibenzothiophene pharmacophore and the discovery of aminobenzothiophenes as potent inhibitors of Mycobacterium smegmatis	11
Enzymatic reconstitution of salicylate formation in promysalin biosynthesis	11
Recent advances and perspectives in therapeutics for mpox	11
Design, synthesis and activity evaluation of Hedgehog inhibitor Itraconazole derivatives in A549 cells	11
Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis	11
Discovery of novel N-(1-benzyl-1H-imidazol-2-yl)amide derivatives as melanocortin 1 receptor agonists	11
Design, synthesis and evaluation of clickable photoaffinity probes for nuclear lamins	11
Study of the reversal of metallo-β-lactamase-mediated resistance in Gram-negative bacteria by EDTMP	11
Discovery and characterization a new collagenase from Hathewaya massiliensis for effective subcutaneous adipolysis	11
Synthesis of a tricyclic hexapeptide –via two consecutive ruthenium-catalyzed macrocyclization steps– with a constrained topology to mimic vancomycin's binding properties toward D-Ala-D-Ala dipeptide	11
Graphical Abstract Continued	11
Syntheses and antitumor activities of neorautenol and shinpterocarpin analogs	11
Editorial Board	11
Discovery of triazenyl triazoles as Nav1.1 channel blockers for treatment of epilepsy	11
A unified “top-down” approach for the synthesis of diverse lead-like molecular scaffolds	11
Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides	10
Synthesis of a new series of quinoline/pyridine indole-3-sulfonamide hybrids as selective carbonic anhydrase IX inhibitors	10
Investigation of the site 2 pocket of Grp94 with KUNG65 benzamide derivatives	10
Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment	10
Harnessing dual-mode RIPK1 ligands for cross-species anti-necroptosis inhibitor compounds	10
Contents continued	10
The Pyrimidinyl Hydrazones: Selective for anti-Cancer cytotoxicity	10
Discovery of a potent orally available pyrazolopyridone derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor	10
Synthesis of substrate peptides incorporating non-natural amino acids and screening study using BACE1	10
Discovery of novel 4-aminobenzamide derivatives as small molecule CBX2 inhibitors	10
Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei	10
Improving reactivity of naphthalimide-based GST probe by imparting TPP cation: Development and application for live cell imaging	10
A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion	10
Discovery of sinomenine/8-Bis(benzylthio)octanoic acid hybrids as potential anti-leukemia drug candidate via mitochondrial pathway	10
Graphical abstract TOC	10
A small-molecule pretargeting approach for PSMA-targeted conjugates	10
Design, synthesis and antitumor evaluation of a novel nectin-4 targeting bicyclic toxin conjugate	10
Development of novel GI-centric prostaglandin E2 receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases	10
Design, synthesis and evaluation of pterostilbene-indole hybrids as potential anticancer agents	10
Design, synthesis and biological evaluation of novel cationic liposomes loaded with melphalan for the treatment of cancer	10
Design, synthesis and anti-pneumonic activity evaluation of shikonin ester derivatives	10
Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors	10
6-Aryl-quinazolines as novel GABAB receptor positive allosteric modulators	10
Design, synthesis and biological evaluation of novel indole-piperazine derivatives as antibacterial agents	10
Synthesis and functional evaluation of tetrahydroisoquinoline and polysubstituted benzylamine derivatives as sigma-2 receptor-targeted small-molecule probes	10
Discovery of 3-acyl-2-anilino-1,4-dihydroquinolin-4-one derivatives as potential inhibitors of methicillin-resistant Staphylococcus aureus	10
Contents continued	10
Genipin derivative induced the apoptosis and inhibited the invasion and migration of A549 cancer cells via regulation of EGFR/JAK1/STAT3 signaling	9
Graphical abstract TOC	9
Permeation behavior of porphyrin derivatives with different functional group positions across cancer cell membranes	9
A guanidinium group is an effective mimic of the tertiary carbocation formed by isopentenyl diphosphate isomerase	9
PSMA-targeted SMART molecules outfitted with SN38	9
Hydrazinecarbonyl-thiazol-2-acetamides with pronounced apoptotic behavior: synthesis, in vitro/in vivo anti-proliferative activity and molecular modeling simulations	9
Methyl N-(tert-butoxycarbonyl)pyridine-2-carbimidothioate: A new reagent for the synthesis of N-phenylpyridinecarboxamidine (“arylimidamide”) DNA-minor groove binders from poorly nucleophilic amines	9

Editorial Board	9
Synthesis of drimanyl indole fragments of drimentine alkaloids and their antibacterial activities	9
A small molecule binding to TGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 31	9
Iodophenyl-conjugated closo-dodecaborate as a promising small boron molecule that binds to serum albumin and accumulates in tumor	9
Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3	9
Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses	9
Imidazo[2,1-b]thiazole based indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor: Structure based design, synthesis, bio-evaluation and docking studies	9
Graphical abstract TOC	9
Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine inhibitors of hematopoietic progenitor kinase 1	9
Synthesis, modeling, and biological evaluation of anti-tubulin indole-substituted furanones	9
Further structural optimization and SAR study of sungsanpin derivatives as cell-invasion inhibitors	9
PES derivative PESA is a potent tool to globally profile cellular targets of PES	9
Corrigendum to “Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors” [Bioorgan. Med. Chem. Lett. 50 (2021) 128352]	9
Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents	9
Graphical abstract TOC	9
Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer’s disease	9
Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability	9
Editorial Board	9
Synthesis, in vitro cytotoxicity evaluation and mechanism of 5′ monosubstituted chalcone derivatives as antitumor agents	9
Cyano-Hydrol green derivatives: Expanding the 9-cyanopyronin-based resonance Raman vibrational palette	9
Graphical abstract TOC	9
Evaluation of an ester-linked immunosuppressive payload: A case study in understanding the stability and cleavability of ester-containing ADC linkers	9
Highly potent anti-inflammatory, analgesic and antioxidant activities of 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine thiones	9
Synthesis and biological evaluation of biotinylated ZJ-101	9
Discovery of a potent and subtype-selective TYK2 degrader based on an allosteric TYK2 inhibitor	9
Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplers	9
Contents continued	9
Discovery of an ellipticine derivative as TLR3 inhibitor against influenza A virus and SARS-CoV-2	9
Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation	9
New diarylpentanoids and chalcones as potential antimicrobial adjuvants	9
Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido[2,3-d]pyrimidin-7-one-based SOS1 inhibitor	9
Novel drug discovery approaches for MMP-13 inhibitors in the treatment of osteoarthritis	9
Graphical Abstract TOC	8
Short synthesis of a broadly Reactive, cell permeable serine hydrolase Fluorophosphonate-Alkyne probe	8
4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators	8
Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins	8
Diamino variants of piperazine-based tissue transglutaminase inhibitors	8
Azolo[5′,1′,2,3]pyrimido[5,4-e]tetrazolo[1,5-c]pyrimidines as dual-action antiglycators and α-glucosidase inhibitors	8
The structural modification and biological evaluation of tetrahydrothienopyridine derivatives as selective BChE inhibitors	8
Synthesis and preliminary immunologic properties of di-/trisaccharide-conjugates related to Bacillus anthracis	8
An ascidian Polycarpa aurata-derived pan-inhibitor against coronaviruses targeting Mpro	8
Graphical Abstract TOC	8
Contents continued	8
Synthesis and properties of PNA containing a dicationic nucleobase based on N4-benzoylated cytosine	8
Exploration of inhibitors of the bacterial LexA repressor-protease	8
Graphical abstract TOC	8
Synthesis and evaluation of catecholamine derivatives as amyloid-beta aggregation inhibitors	8
Sensitive and reliable gastric ulcer related MicroRNA detection by bridge catalytic hairpin assembly (bCHA) mediated primer exchange reaction	8
Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors	8
Novel imidazo[1,5-a]quinoxaline derivatives: SAR, selectivity and modeling challenges en route to the identification of an α5-GABAA receptor NAM	8
Editorial Board	8
Design, synthesis and antitumor activity of novel 4-oxobutanamide derivatives	8
Graphical Abstract Contents Continued	8
Graphical abstract TOC	8
Synthesis and antitumor activity of a series of novel N-aryl-5-(2,2,2-trifluoroethoxy)-1,5-dihydro-2H-pyrrol-2-ones derivatives	8
Design, synthesis and biological evaluation of sulfonylurea derivatives as NLRP3 inflammasome inhibitors	8
Graphical abstract TOC	8
Design of cyclic peptides as novel inhibitors of ICOS/ICOSL interaction	8
Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase	8
Synthesis of proposed structure of ledebourin A	8
Multigram-scale total synthesis of (±)-ambreinolide by a diastereoselective polyene cyclization	8
5-Fluoro-2′-deoxyuridine as an efficient 19F NMR reporter for G-quadruplex and i-motif structures	8
SAR study of niclosamide derivatives for neuroprotective function in SH-SY5Y neuroblastoma	8
Synthesis, radiolabeling, and evaluation of a potent β-site APP cleaving enzyme (BACE1) inhibitor for PET imaging of BACE1 in vivo	7
Design of a ROS-responsive fluorescent probe for the diagnosis and imaging of breast cancer	7
Editorial Board	7
Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity	7
Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance	7
Design and synthesis of novel orexin 2 receptor agonists based on naphthalene skeleton	7
Structure-activity relationship study of antitrypanosomal analogues of gibbilimbol B using multivariate analysis and computation-aided drug design	7
Graphical abstract TOC	7
Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3	7
Discovery of EP300/CBP histone acetyltransferase inhibitors through scaffold hopping of 1,4-oxazepane ring	7
Rational design, synthesis, antiproliferative activity against MCF-7, MDA-MB-231 cells, estrogen receptors binding affinity, and computational study of indenopyrimidine-2,5-dione analogs for the treat	7
Discovery of 4-((quinolin-8-ylthio)methyl)benzamide derivatives as a new class of SARS-CoV-2 nsp13 inhibitors	7
Design, synthesis, and biological evaluation of novel aminopyrimidine derivatives as EGFR inhibitors	7
Fragment-based discovery of novel phenyltriazolyl derivatives as allosteric type-I1/2 ALK inhibitors with promising antitumor effects	7
The potential of Rhein's aromatic amines for Parkinson's disease prevention and treatment: α-Synuclein aggregation inhibition and disaggregation of preformed fibers	7
Development of chromone-thiazolidine-2,4-dione Knoevenagel conjugates as apoptosis inducing agents	7
Design, synthesis, and activity evaluation of Asiatic acid derivatives as Survivin inhibitors	7
A FOXC2 inhibitor, MC-1-F2, as a therapeutic candidate for targeting EMT in castration-resistant prostate cancer	7
Conformationally constrained potent inhibitors for enhancer of zeste homolog 2 (EZH2)	7
Design, synthesis and antifungal activities of novel triazole derivatives with selenium-containing hydrophobic side chains	7
Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1	7
Synthesis and biological evaluation of novel 18F-labeled 2,4-diaminopyrimidine derivatives for detection of ghrelin receptor in the brain	7
Siderophores: Chemical tools for precise antibiotic delivery	7
Editorial Board	7
Editorial Board	7
Novel detection method for gallic acid: A water soluble boronic acid-based fluorescent sensor with double recognition sites	7
Design, synthesis, and biological evaluation of novel HDAC inhibitors with a 3-(benzazol-2-yl)quinoxaline framework	7
Graphical abstract TOC	7
Graphical Abstract Contents Continued	7
Editorial Board	7
Discovery of benzimidazole-2-amide BNZ-111 as new tubulin inhibitor	7
Identification of sugar-containing natural products that interact with i-motif DNA	7