Bioorganic & Medicinal Chemistry Letters

Article	Citations
Design, synthesis and biological evaluation of alginate oligosaccharide derivatives	154
Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site	77
Design, synthesis and biological evaluation of tanshinone IIA derivatives as NLRP3 inflammasome inhibitors	73
Enteroviral replication inhibition by N-Alkyl triazolopyrimidinone derivatives through a non-capsid binding mode	58
Revisiting the dipeptidyl carboxypeptidase inhibitor captopril as a source of pan anti-trypanosomatid agents	54
Novel carbohydrate-based sulfonamide derivatives as selective carbonic anhydrase II inhibitors: Synthesis, biological and molecular docking analysis	46
Editorial Board	45
Synthesis and biological evaluation of novel 1,2,3,4-tetrahydro-β-carboline derivatives as potential antibacterial agents	43
Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators	40
Design of 99mTc-labeled zinc-chelating imaging probe for SPECT imaging of the pancreas	39
Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model	38
Graphical Abstract TOC	34
Studies on in vitro modulatory effects to base excision repair enzymes induced by small molecule binding to Deaminated CAG repeat hairpin	32
Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent	31
Editorial Board	31
Editorial Board	31
Non-alkylator anti-glioblastoma agents induced cell cycle G2/M arrest and apoptosis: Design, in silico physicochemical and SAR studies of 2-aminoquinoline-3-carboxamides	30
Green synthesis and anti-biofilm activities of 3,5-disubstituted isoxazoline/isoxazole-linked secondary sulfonamide derivatives on Pseudomonas aeruginosa	30
New class of fused [3,2-b][1,2,4]triazolothiazoles for targeting glioma in vitro	30
Development of a highly potent and selective degrader of LRRK2	28
Phytochemical investigation of Asarum sieboldii var. seoulense and the phenotypic profiles of its constituents against a Parkinson’s Disease olfactory cell line	27
A fluorescent molecular rotor for the selective detection of the hybrid-conformation 22AG G-Quadruplex	26
Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor	25
Discovery of novel iminosydnone compounds with insecticidal activities based on the binding mode of triflumezopyrim	25
Improved synthesis and anticancer activity of a potent neuronal nitric oxide synthase inhibitor	24

Design and evaluation of anaplastic lymphoma kinase degraders using a covalent fumarate handle	24
Contents continued	23
Epigallocatechin and epigallocatechin-3-gallate are not inhibitors of tyrosinase	23
Design, synthesis and characterizations of prodrugs of brexanolone	22
Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor	22
Armeniaspirol analogues disrupt the electrical potential (ΔΨ) of the proton motive force	22
Discovery of quinuclidine modulators of cellular progranulin	22
The ester derivatives obtained by C-ring modification of podophyllotoxin induce apoptosis and inhibited proliferation in PC-3M cells via down-regulation of PI3K/Akt signaling pathway	21
A PSMA-targeted doxorubicin small-molecule drug conjugate	21
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads	21
Pyrazolo-1-carbothioamides as EGR-1–DNA binding disruptors	20
Neuropilin 1-targeted near-infrared fluorescence probes for tumor diagnosis	20
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity	20
New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants	19
Design, synthesis, biological evaluation and molecular modeling of N-isobutyl-N-((2-(p-tolyloxymethyl)thiazol-4yl)methyl)benzo[d][1,3] dioxole-5-carboxamides as selective butyrylcholinesterase inhibit	19
A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation	19
Discovery of DS-1093a: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia	19
Contents continued	18
Contents continued	18
Editorial Board	18
Topoisomerase IIα inhibitory and antiproliferative activity of dihydroxylated 2,6-diphenyl-4-fluorophenylpyridines: Design, synthesis, and structure-activity relationships	17
Graphical abstract TOC	17
Graphical abstract TOC	17
Pharmacokinetic analysis of 6-O-[18F]FEE for PET imaging of EGFR mutation	17
Photocrosslinking and capture for the analysis of carbohydrate-dependent interactions	17
Exploratory study of oxatomide derivatives with high P2X7 receptor inhibitory activity	17
pH-responsive aggregates consisted of oligodeoxynucleotides bearing nitrophenol group that deliver drugs into acidic cells	17
Graphical abstract TOC	17
Design, synthesis, and biological evaluation of 5ʹ-deoxy (N)-methanocarbanucleoside derivatives as A3 adenosine receptor ligands	17
Graphical abstract TOC	17
Graphical abstract TOC	17
Design, synthesis and biological evaluation of pteridine-7(8H)-one derivatives as potent and selective CDK4/6 inhibitors	17
Discovery of arylsulfonamides as a novel class of allosteric integrase inhibitors with antiviral activity	16
Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV)	16
DDD-028: A potent, neuroprotective, non-opioid compound for the treatment of diabetic neuropathy	16
Retraction notice to “Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities” [Bioorg. Med. Chem. Lett. 22(9) (2012) 3067–	16
High-yield and high-purity amide bond formation using DMTMM PF6 for DNA-encoded libraries	16
Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors	16
α-Fluorination of tropane compounds and its impact on physicochemical and ADME properties	16
Design, synthesis and biological evaluation of novel procaine derivatives for intravenous anesthesia	16
Design and activity evaluation of new EGFR tyrosine kinase inhibitors containing cyclic polyamines	16
Discovery and optimization of (2-naphthylthio)acetic acid derivative as selective Bfl-1 inhibitor	16
Biological evaluation of newly synthesized α-benzil monoxime thiocarbohydrazide derivatives as an antimicrobial and anticancer agent: In vitro screening and ADMET predictions	16
Optimisation of momelotinib with improved potency and efficacy as pan-JAK inhibitor	16
Contents continued	16
nTZDpa (non-thiazolidinedione PPARγ partial agonist) derivatives retain antimicrobial activity without improving renal toxicity	15
Design, synthesis and biological evaluation of novel cyano-cinnamate derivatives as mitochondrial pyruvate carrier inhibitors	15
Ultrasound-dependent RNAi using TatU1A-rose bengal conjugate	15
Design, synthesis and properties of peptide inhibitors based on BRCA1856-871	15
Biocatalytic synthesis and evaluation of antioxidant and antibacterial activities of hydroxyequols	15

An overview of cyclopropenone derivatives as promising bioactive molecules	15
PEG-lipid-modified agonistic antibody against tumor necrosis factor receptor family elicits superior apoptosis-inducing activity against human carcinoma	15
(E)-3-(3-([1,1′-Biphenyl]-4-yl)-1-phenyl-1H-pyrazol-4-yl)-1-phenylprop-2-en-1-ones inducing reactive oxygen species generation through glutathione depletion	14
Design and synthesis of novel fluorene derivatives as inhibitors of pyruvate dehydrogenase kinase	14
Novel pyridinium-type fullerene derivatives as multitargeting inhibitors of HIV-1 reverse transcriptase, HIV-1 protease, and HCV NS5B polymerase	14
Rational design, synthesis and biological evaluation of novel HIV-1 protease inhibitors containing 2-phenylacetamide derivatives as P2 ligands with potent activity against DRV-Resistant HIV-1 variants	14
Stereochemical inversion at a 1,4-cyclohexyl PROTAC linker fine-tunes conformation and binding affinity	14
Synthesis of a new series of quinoline/pyridine indole-3-sulfonamide hybrids as selective carbonic anhydrase IX inhibitors	14
Design, synthesis and activity evaluation of Hedgehog inhibitor Itraconazole derivatives in A549 cells	14
Design, synthesis and biological evaluation of pyrimidine base hydroxamic acid derivatives as dual JMJD3 and HDAC inhibitors	14
Comparative analysis of p-terphenylquinone and seriniquinone derivatives as reactive oxygen species-modulating agents	14
Synthesis and evaluation of lipoic acid – donepezil hybrids for Alzheimer’s disease using a straightforward strategy	14
Synthesis and evaluation of potent novel inhibitors of human sulfide:quinone oxidoreductase	14
Editorial Board	14
Improving reactivity of naphthalimide-based GST probe by imparting TPP cation: Development and application for live cell imaging	14
Synthesis of a tricyclic hexapeptide –via two consecutive ruthenium-catalyzed macrocyclization steps– with a constrained topology to mimic vancomycin's binding properties toward D-Ala-D-Ala dipeptide	14
Synthesis and evaluation of 3-hydroxyquinolin-2(1H)-one derivatives as inhibitors of tyrosinase	14
Synthesis and pharmacological characterization of multiply substituted 2H-chromene derivatives as P2Y6 receptor antagonists	14
A photoactivatable self-localizing ligand with improved photosensitivity for chemo-optogenetic control of protein localization in living cells	14
Synthesis of dolutegravir derivatives modified by 1,2,3-triazole structure and their anti-inflammatory activity in LPS-induced BV2 cells	14
Design and synthesis of a series of OFF-ON near infrared fluorescent probes for nucleic acid in aqueous solution	14
Editorial Board	13
Graphical Abstract Continued	13
Design, synthesis and biological evaluation of cajanonic acid A analogues as potent PPAR γ antagonists	13
Reinvestigation of clopidogrel bioactivation unveils new cytochrome P450-catalyzed thioester cleavage mechanism	13
Graphical Abstract Contents Continued	13
Discovery of novel N-(1-benzyl-1H-imidazol-2-yl)amide derivatives as melanocortin 1 receptor agonists	13
Synthesis and biological evaluation of substituted amide derivatives of C4-ageratochromene dimer analog	13
Discovery of triazenyl triazoles as Nav1.1 channel blockers for treatment of epilepsy	13
6-Aryl-quinazolines as novel GABAB receptor positive allosteric modulators	13
Editorial Board	13
Graphical abstract TOC	13
Structure–activity relationship of 2-aminodibenzothiophene pharmacophore and the discovery of aminobenzothiophenes as potent inhibitors of Mycobacterium smegmatis	13
Graphical abstract TOC	13
Editorial Board	13
Contents continued	12
Structure-activity relationship of dual inhibitors containing maleimide and imidazole motifs against glutaminyl cyclase and glycogen synthase kinase-3β	12
Design, synthesis, and biological evaluation of polyphenol derivatives as DYRK1A inhibitors. The discovery of a potentially promising treatment for Multiple Sclerosis	12
Antibacterial activity of β-sitosterol isolated from the leaves of Odontonema strictum (Acanthaceae)	12
Phenyl urea based adjuvants for β-lactam antibiotics against methicillin resistant Staphylococcus aureus	12
Neratinib derivative 7A induces apoptosis in colon cancer cells via the p53 pathway	12
Discovery of dronedarone and its analogues as NLRP3 inflammasome inhibitors with potent anti-inflammation activity	12
A unified “top-down” approach for the synthesis of diverse lead-like molecular scaffolds	12
A dual aurora and lim kinase inhibitor reduces glioblastoma proliferation and invasion	12
Structure-activity relationship of dibenzylideneacetone analogs against the neglected disease pathogen, Trypanosoma brucei	12
Design, synthesis, in silico studies, and antiproliferative evaluations of novel indolin-2-one derivatives containing 3-hydroxy-4-pyridinone fragment	12
Graphical abstract TOC	12
Enzymatic reconstitution of salicylate formation in promysalin biosynthesis	12
Discovery of sinomenine/8-Bis(benzylthio)octanoic acid hybrids as potential anti-leukemia drug candidate via mitochondrial pathway	12
Graphical abstract TOC	12
Design, synthesis and biological evaluation of novel cationic liposomes loaded with melphalan for the treatment of cancer	12
Identification of potent and selective inhibitors of PKR via virtual screening and traditional design	12
Contents continued	11
Synthesis of mizoribine prodrugs and their in vivo evaluation as immunosuppressive agents	11
Contents continued	11
Syntheses and antitumor activities of neorautenol and shinpterocarpin analogs	11
Direct-to-biology platform: From synthesis to biological evaluation of SHP2 allosteric inhibitors	11
Editorial Board	11
PSMA-targeted SMART molecules outfitted with SN38	11
Synthesis and evaluation of antimycobacterial activity of riboflavin derivatives	11
Graphical abstract TOC	11
Corrigendum to “Discovery of 4-aminopyrimidine analogs as highly potent dual P70S6K/Akt inhibitors” [Bioorgan. Med. Chem. Lett. 50 (2021) 128352]	11
Graphical abstract TOC	11
Rationalizing the binding and α subtype selectivity of synthesized imidazodiazepines and benzodiazepines at GABAA receptors by using molecular docking studies	11
Methyl N-(tert-butoxycarbonyl)pyridine-2-carbimidothioate: A new reagent for the synthesis of N-phenylpyridinecarboxamidine (“arylimidamide”) DNA-minor groove binders from poorly nucleophilic amines	11
Discovery of 3-acyl-2-anilino-1,4-dihydroquinolin-4-one derivatives as potential inhibitors of methicillin-resistant Staphylococcus aureus	11
A guanidinium group is an effective mimic of the tertiary carbocation formed by isopentenyl diphosphate isomerase	11
Graphical abstract TOC	11
Investigation of the site 2 pocket of Grp94 with KUNG65 benzamide derivatives	11
Graphical abstract TOC	11
SAR towards indoline and 3-azaindoline classes of IDO1 inhibitors	11
Potent and selective carbonic anhydrase inhibition activities of pyrazolones bearing benzenesulfonamides	11
Graphical abstract TOC	11
Development of novel GI-centric prostaglandin E2 receptor type 4 (EP4) agonist prodrugs as treatment for ulcerative colitis and other intestinal inflammatory diseases	11
Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplers	10
Highly potent anti-inflammatory, analgesic and antioxidant activities of 3,5-disubstituted tetrahydro-2H-1,3,5-thiadiazine thiones	10
Photo-regulated PROTACs: A novel tool for temporal control of targeted protein degradation	10
Novel drug discovery approaches for MMP-13 inhibitors in the treatment of osteoarthritis	10
Hydrazinecarbonyl-thiazol-2-acetamides with pronounced apoptotic behavior: synthesis, in vitro/in vivo anti-proliferative activity and molecular modeling simulations	10
A small-molecule pretargeting approach for PSMA-targeted conjugates	10

Design, synthesis and biological evaluation of novel indole-piperazine derivatives as antibacterial agents	10
Discovery of BI-9787, a potent zwitterionic ketohexokinase inhibitor with oral bioavailability	10
A small molecule binding to TGGAA pentanucleotide repeats that cause spinocerebellar ataxia type 31	10
Further structural optimization and SAR study of sungsanpin derivatives as cell-invasion inhibitors	10
Permeation behavior of porphyrin derivatives with different functional group positions across cancer cell membranes	10
Designing a novel photoinduced electron transfer-based small-molecule fluorescent probe specific for CYP3A isozymes	10
Discovery of an ellipticine derivative as TLR3 inhibitor against influenza A virus and SARS-CoV-2	10
Discovery of a potent orally available pyrazolopyridone derivative as a novel selective bromodomain and extra-terminal domain (BET)-first bromodomain (BD1) inhibitor	10
Evaluation of an ester-linked immunosuppressive payload: A case study in understanding the stability and cleavability of ester-containing ADC linkers	10
New diarylpentanoids and chalcones as potential antimicrobial adjuvants	10
PES derivative PESA is a potent tool to globally profile cellular targets of PES	10
Cyano-Hydrol green derivatives: Expanding the 9-cyanopyronin-based resonance Raman vibrational palette	10
Harnessing dual-mode RIPK1 ligands for cross-species anti-necroptosis inhibitor compounds	10
Design, synthesis, and bioevaluation of SOS1 PROTACs derived from pyrido[2,3-d]pyrimidin-7-one-based SOS1 inhibitor	10
Synthesis, in vitro cytotoxicity evaluation and mechanism of 5′ monosubstituted chalcone derivatives as antitumor agents	10
Discovery of a proteolysis targeting chimera (PROTAC) as a potent regulator of FOXP3	10
Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer’s disease	10
Synthesis, modeling, and biological evaluation of anti-tubulin indole-substituted furanones	10
Synthesis and biological evaluation of biotinylated ZJ-101	10
Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine inhibitors of hematopoietic progenitor kinase 1	10
Iodophenyl-conjugated closo-dodecaborate as a promising small boron molecule that binds to serum albumin and accumulates in tumor	10
Synthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore	10
Discovery of a potent and subtype-selective TYK2 degrader based on an allosteric TYK2 inhibitor	10
Retraction notice to “Synthesis and bioevaluation of aryl-guanidino polyamine conjugates targeting the polyamine transporter” [Bioorg. Med. Chem. Lett. 20 (2010) 6421–6425]	9
Graphical abstract TOC	9
Graphical Abstract Contents Continued	9
Multigram-scale total synthesis of (±)-ambreinolide by a diastereoselective polyene cyclization	9
Discovery of a DCAF11-dependent cyanoacrylamide-containing covalent degrader of BET-proteins	9
Activation of 8–17 DNAzyme with extra functional group at conserved residues is related to catalytic metal ion	9
Editorial Board	9
Synthesis of drimanyl indole fragments of drimentine alkaloids and their antibacterial activities	9
Discovery of aryl aminothiazole γ-secretase modulators with novel effects on amyloid β-peptide production	9
Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold	9
Graphical abstract TOC	9
Contents continued	9
Graphical Abstract TOC	9
Synthesis of esters and amides of 2-aryl-1-hydroxy-4-methyl-1H-imidazole-5-carboxylic acids and study of their antiviral activity against orthopoxviruses	9
Synthesis of proposed structure of ledebourin A	9
Contents continued	9
Thiamine analogues featuring amino-oxetanes as potent and selective inhibitors of pyruvate dehydrogenase	9
5-Fluoro-2′-deoxyuridine as an efficient 19F NMR reporter for G-quadruplex and i-motif structures	9
Diamino variants of piperazine-based tissue transglutaminase inhibitors	9
Discovery of acyl ureas as highly selective small molecule CSF1R kinase inhibitors	9
Graphical abstract TOC	9
Novel imidazo[1,5-a]quinoxaline derivatives: SAR, selectivity and modeling challenges en route to the identification of an α5-GABAA receptor NAM	9
Graphical Abstract TOC	9
Imidazo[2,1-b]thiazole based indoleamine-2,3-dioxygenase 1 (IDO1) inhibitor: Structure based design, synthesis, bio-evaluation and docking studies	9
Synthesis and antitumor activity of a series of novel N-aryl-5-(2,2,2-trifluoroethoxy)-1,5-dihydro-2H-pyrrol-2-ones derivatives	9
Synthesis and properties of PNA containing a dicationic nucleobase based on N4-benzoylated cytosine	9
Pyrimidine-2,4-dione targets STAT3 signaling pathway to induce cytotoxicity in hepatocellular carcinoma cells	9
Design, synthesis and antiproliferative activity of novel 2,4-diamino-5-methyleneaminopyrimidine derivatives as potential anticancer agents	9
Synthesis and evaluation of catecholamine derivatives as amyloid-beta aggregation inhibitors	9
An ascidian Polycarpa aurata-derived pan-inhibitor against coronaviruses targeting Mpro	9
Editorial Board	9
Recent developments of benzimidazole based analogs as potential tubulin polymerization inhibitors: A critical review	8
Graphical abstract TOC	8
Editorial Board	8
Graphical abstract TOC	8
Identification of (−)-Epigallocateshin gallate derivatives promoting innate immune activation via 2′,3′-cyclic GMP-AMP-stimulator of interferon genes pathway	8
Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity	8
Inhibition of glutathione S-transferases by photoactive calix[4]arene α-ketophosphonic acids	8
Design, synthesis and antitumor activity of novel 4-oxobutanamide derivatives	8
Editorial Board	8
4-Oxooctahydroquinoline-1(2H)-carboxamides as hepatitis B virus (HBV) capsid core protein assembly modulators	8
Graphical abstract TOC	8
Design of cyclic peptides as novel inhibitors of ICOS/ICOSL interaction	8
Inhibitors for metallo-β-lactamases from the B1 and B3 subgroups provide an avenue to combat a major mechanism of antibiotic resistance	8
Synthesis and preliminary immunologic properties of di-/trisaccharide-conjugates related to Bacillus anthracis	8
The lipidation and glycosylation enabling bioactivity enhancement and structural change of antibacterial peptide G3	8
Design, synthesis and biological evaluation of sulfonylurea derivatives as NLRP3 inflammasome inhibitors	8
Graphical Abstract Contents Continued	8
Novel detection method for gallic acid: A water soluble boronic acid-based fluorescent sensor with double recognition sites	8
Expanded library of novel 2,3-pyrrolidinedione analogues exhibit anti-biofilm activity	8
Strategic structure–activity relationship study on a follistatin-derived myostatin inhibitory peptide	8
The structural modification and biological evaluation of tetrahydrothienopyridine derivatives as selective BChE inhibitors	8
l-Hypaphorine and d-hypaphorine: Specific antiacetylcholinesterase activity in rat brain tissue	8
Development of chromone-thiazolidine-2,4-dione Knoevenagel conjugates as apoptosis inducing agents	8
Graphical abstract TOC	8
SAR study of niclosamide derivatives for neuroprotective function in SH-SY5Y neuroblastoma	8
Editorial Board	8
Estimation of the lipophilicity of purine-2,6-dione-based TRPA1 antagonists and PDE4/7 inhibitors with analgesic activity	8
Sensitive and reliable gastric ulcer related MicroRNA detection by bridge catalytic hairpin assembly (bCHA) mediated primer exchange reaction	8
Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFRdel19/T790M/C797S and EGFRL858R/T790M/C797S)	8
Retraction notice to “Corrigendum to “Preclinical metabolism of LB42908, a novel farnesyl transferase inhibitor, and its effects on the cytochrome P450 isozyme activities” [Bioorg. Med. Chem. Lett. 22	8
Thermal treatment affects aptamers’ structural profiles	8
The association between oxidized low-density lipoprotein and cancer: An emerging targeted therapeutic approach?	8
Synthesis and biological evaluation of novel 18F-labeled 2,4-diaminopyrimidine derivatives for detection of ghrelin receptor in the brain	8
Discovery of the potent covalent inhibitor with an acrylate warhead for SARS-CoV-2 3CL protease	8
Exploration of inhibitors of the bacterial LexA repressor-protease	8
Aiming to improve binding of porphyrin diphenyl guanidinium conjugates to guanine-quadruplexes: When size matters	8
Design, synthesis, and biological evaluation of novel HDAC inhibitors with a 3-(benzazol-2-yl)quinoxaline framework	8
Editorial Board	8
Synthesis, antiproliferative activity, and biological profiling of C-19 trityl and silyl ether andrographolide analogs in colon cancer and breast cancer cells	8
Editorial Board	8
Identification of Plasmodium falciparum falcilysin inhibitors by a virtual screen	8