Bioorganic & Medicinal Chemistry Letters

Article	Citations
The SARS-CoV-2 main protease as drug target	538
Main protease mutants of SARS-CoV-2 variants remain susceptible to nirmatrelvir	126
Pyridones in drug discovery: Recent advances	70
The relationship between the structure and toxicity of aminoglycoside antibiotics	63
Structural hybridization as a facile approach to new drug candidates	60
Synthesis, biological evaluation of benzothiazole derivatives bearing a 1,3,4-oxadiazole moiety as potential anti-oxidant and anti-inflammatory agents	58
Recent advances in antibacterial agents	53
New coumarin-benzotriazole based hybrid molecules as inhibitors of acetylcholinesterase and amyloid aggregation	52
The expanding reaction toolkit for DNA-encoded libraries	51
Cryo-EM as a powerful tool for drug discovery	49
1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies	48
Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents	47
Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study	44
Structure and bioactivity of colibactin	44
Selective CDK6 degradation mediated by cereblon, VHL, and novel IAP-recruiting PROTACs	41
Discovery and biological evaluation of proteolysis targeting chimeras (PROTACs) as an EGFR degraders based on osimertinib and lenalidomide	37
Synthesis and biological evaluation of anti-tubercular activity of Schiff bases of 2-Amino thiazoles	35
Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax	34
Design, synthesis, biological evaluation and molecular docking of new uracil analogs-1,2,4-oxadiazole hybrids as potential anticancer agents	34
Synthesis and biological evaluation of novel quinazoline-triazole hybrid compounds with potential use in Alzheimer’s disease	33
Unique para-aminobenzenesulfonyl oxadiazoles as novel structural potential membrane active antibacterial agents towards drug-resistant methicillin resistant Staphylococcus aureus	33
Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition	33
Novel isoniazid embedded triazole derivatives: Synthesis, antitubercular and antimicrobial activity evaluation	32
Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects	32
New bis- and tetrakis-1,2,3-triazole derivatives: Synthesis, DNA cleavage, molecular docking, antimicrobial, antioxidant activity and acid dissociation constants	32

Novel vanillin derivatives containing a 1,3,4-thiadiazole moiety as potential antibacterial agents	31
New vinyl-1,2,4-triazole derivatives as antimicrobial agents: Synthesis, biological evaluation and molecular docking studies	31
Synthesis and anti-proliferative activity of a novel 1,2,3-triazole tethered chalcone acetamide derivatives	31
Click synthesis of 1,2,3-triazole based imidazoles: Antitubercular evaluation, molecular docking and HSA binding studies	30
Exploring the potential of novel phenolic compounds as potential therapeutic candidates against SARS-CoV-2, using quantum chemistry, molecular docking and dynamic studies	30
Structure–activity relationships of GPX4 inhibitor warheads	29
Synthesis of novel of 2, 5-disubstituted 1, 3, 4- oxadiazole derivatives and their in vitro anti-inflammatory, anti-oxidant evaluation, and molecular docking study	28
Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors	28
Fused benzo[1,3]thiazine-1,2,3-triazole hybrids: Microwave-assisted one-pot synthesis, in vitro antibacterial, antibiofilm, and in silico ADME studies	28
Pyrimidine-conjugated fluoroquinolones as new potential broad-spectrum antibacterial agents	28
Modulation of DNA and RNA by PNA	28
Design, synthesis and evaluation of hydrazine and acyl hydrazone derivatives of 5-pyrrolidin-2-one as antifungal agents	28
The signal peptide as a new target for drug design	27
Synthesis and antifungal activity of imidazo[1,2-b]pyridazine derivatives against phytopathogenic fungi	27
Chemical update on the potential for serotonin 5-HT6 and 5-HT7 receptor agents in the treatment of Alzheimer’s disease	26
A first-in-class clinical G-quadruplex-targeting drug. The bench-to-bedside translation of the fluoroquinolone QQ58 to CX-5461 (Pidnarulex)	26
A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation	26
Synthesis, α-glucosidase inhibition, and molecular docking studies of novel N-substituted hydrazide derivatives of atranorin as antidiabetic agents	25
Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease	25
Design and synthesis of new indanol-1,2,3-triazole derivatives as potent antitubercular and antimicrobial agents	25
Fluorescent metal-based complexes as cancer probes	25
Design, synthesis and anti-influenza A virus activity of novel 2,4-disubstituted quinazoline derivatives	25
Ibrexafungerp: An orally active β-1,3-glucan synthesis inhibitor	24
Synthesis and antifungal activity of new hybrids thiazolo[4,5-d]pyrimidines with (1H-1,2,4)triazole	24
Neurotrophic isoindolinones from the fruiting bodies of Hericium erinaceus	23
Design and synthesis of purine connected piperazine derivatives as novel inhibitors of Mycobacterium tuberculosis	23
Assessing different thiazolidine and thiazole based compounds as antileishmanial scaffolds	23
Novel benzothiazole-based dual VEGFR-2/EGFR inhibitors targeting breast and liver cancers: Synthesis, cytotoxic activity, QSAR and molecular docking studies	23
Design, synthesis and antibacterial evaluation of novel oxazolidinone derivatives nitrogen-containing fused heterocyclic moiety	23
Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines	23
Design, synthesis and molecular modeling studies of novel mesalamine linked coumarin for treatment of inflammatory bowel disease	23
Study on antitumor activities of the chrysin-chromene-spirooxindole on Lewis lung carcinoma C57BL/6 mice in vivo	23
Semisynthesis and insecticidal bioactivities of benzoxazole and benzoxazolone derivatives of honokiol, a naturally occurring neolignan derived from Magnolia officinalis	22
Progress of tubulin polymerization activity detection methods	22
Preparations and antioxidant activities of sesamol and it's derivatives	22
Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton	22
Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity	21
Medicinal chemistry strategies to extend duration of action of inhaled drugs for intracellular targets	21
Biotin and glucose dual-targeting, ligand-modified liposomes promote breast tumor-specific drug delivery	21
Promising anti-SARS-CoV-2 drugs by effective dual targeting against the viral and host proteases	21
Design, synthesis and molecular docking studies of imidazole and benzimidazole linked ethionamide derivatives as inhibitors of InhA and antituberculosis agents	21
Novel triazole-sulfonamide bearing pyrimidine moieties with carbonic anhydrase inhibitory action: Design, synthesis, computational and enzyme inhibition studies	21
Holistic drug design for multiparameter optimization in modern small molecule drug discovery	21
Methylene blue-based 7-nitro-1,2,3-benzoxadiazole NIR fluorescent probe triggered by H2S	21
One-step radiosynthesis and initial evaluation of a small molecule PET tracer for PD-L1 imaging	21
Synthesis of novel potent cytotoxicy podophyllotoxin-naphthoquinone compounds via microwave-assited multicomponent domino reactions	21
Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis	21
Angiokinase inhibition of VEGFR-2, PDGFR and FGFR and cell growth inhibition in lung cancer: Design, synthesis, biological evaluation and molecular docking of novel azaheterocyclic coumarin derivative	21
Synthesis of novel tryptanthrin derivatives as dual inhibitors of indoleamine 2,3-dioxygenase 1 and tryptophan 2,3-dioxygenase	20
Green synthesis of therapeutically active 1,3,4-oxadiazoles as antioxidants, selective COX-2 inhibitors and their in silico studies	20

Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease	20
Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase	20
Isatin-derived azoles as new potential antimicrobial agents: Design, synthesis and biological evaluation	20
Discovery of a series of ester-substituted NLRP3 inflammasome inhibitors	20
Discovery of cyclic sulfonamide derivatives as potent inhibitors of SARS-CoV-2	20
Is GPR146 really the receptor for proinsulin C-peptide?	19
Design and synthesis of amphiphilic 2-hydroxybenzylphosphonium salts with antimicrobial and antitumor dual action	19
The transcriptional repressor REV-ERB as a novel target for disease	19
Design, synthesis, characterization, and anticancer activity of a novel series of O-substituted chalcone derivatives	19
A head-to-head comparison of the inhibitory activities of 15 peptidomimetic SARS-CoV-2 3CLpro inhibitors	19
Potential α-glucosidase inhibitor from Hylotelephium erythrostictum	19
Molecular docking and synthesis of caffeic acid analogous and its anti-inflammatory, analgesic and ulcerogenic studies	19
Discovery of ethyl ketone-based HDACs 1, 2, and 3 selective inhibitors for HIV latency reactivation	19
Chemical constituents of Callistemon citrinus from Egypt and their antiausterity activity against PANC-1 human pancreatic cancer cell line	19
Synthesis and evaluation of anti-tumor activity of novel triazolo[1,5-a] pyrimidine on cancer cells by induction of cellular apoptosis and inhibition of epithelial-to-mesenchymal transition process	19
Synthesis of novel quinoxaline-alkynyl derivatives and their anti-Mycobacterium tuberculosis activity	18
Novel dual LSD1/HDAC6 inhibitors for the treatment of multiple myeloma	18
Targeting G-quadruplexes to achieve antiviral activity	18
Synthesis and biological evaluation of 6-nitro-1,2,4-triazoloazines containing polyphenol fragments possessing antioxidant and antiviral activity	18
In vitro antifungal activities, molecular docking, and DFT studies of 4-amine-3-hydrazino-5-mercapto-1,2,4-triazole derivatives	18
Design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents	18
2-Aryl-3-(6-trifluoromethoxy)benzo[d]thiazole-based thiazolidinone hybrids as potential anti-infective agents: Synthesis, biological evaluation and molecular docking studies	18
Novel PDE5 inhibitors derived from rutaecarpine for the treatment of Alzheimer’s disease	18
Targeting epigenetic modulators using PROTAC degraders: Current status and future perspective	18
Trehalose-based neuroprotective autophagy inducers	17
Antibacterial activity of β-sitosterol isolated from the leaves of Odontonema strictum (Acanthaceae)	17
Synthesis and biological evaluation of novel benzo[a]pyridazino[3,4-c]phenazine derivatives	17
Vinyl sulfone-based inhibitors of trypanosomal cysteine protease rhodesain with improved antitrypanosomal activities	17
Simplistic perylene-related compounds as inhibitors of tick-borne encephalitis virus reproduction	17
Ultrasound assisted synthesis of tetrazole based pyrazolines and isoxazolines as potent anticancer agents via inhibition of tubulin polymerization	17
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines	17
Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines	16
Preparation and antioxidant study of silver nanoparticles of Microsorum pteropus methanol extract	16
New thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, molecular modeling and ADMET study	16
Synthetic approaches towards bedaquiline and its derivatives	16
Design, synthesis and evaluation of novel levoglucosenone derivatives as promising anticancer agents	16
Selections and screenings of DNA-encoded chemical libraries against enzyme and cellular targets	16
Towards the enzymatic synthesis of phosphorothioate containing LNA oligonucleotides	16
Discovery of a simplified deguelin analog as an HSP90 C-terminal inhibitor for HER2-positive breast cancer	16
Bioisosteric substitution of adamantane with bicyclic lipophilic groups improves water solubility of human soluble epoxide hydrolase inhibitors	16
Synthesis and biological evaluation of novel ligustrazine-chalcone derivatives as potential anti-triple negative breast cancer agents	16
A non-aggregated silicon(IV) phthalocyanine-lactose conjugate for photodynamic therapy	16
Potent, non-covalent reversible BTK inhibitors with 8-amino-imidazo[1,5-a]pyrazine core featuring 3-position bicyclic ring substitutes	16
Dihydroquinazolines enhance 20S proteasome activity and induce degradation of α-synuclein, an intrinsically disordered protein associated with neurodegeneration	16
Synthesis and in vitro evaluation of vanillin derivatives as multi-target therapeutics for the treatment of Alzheimer’s disease	16
Discovery of β-carboline-(phenylsulfonyl)furoxan hybrids as potential anti-breast cancer agents	15
Application of niclosamide and analogs as small molecule inhibitors of Zika virus and SARS-CoV-2 infection	15
Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition	15
Design, synthesis and in vitro antitumor evaluation of novel pyrazole-benzimidazole derivatives	15
Discovery and preclinical profile of sudapyridine (WX-081), a novel anti-tuberculosis agent	15
Design, synthesis and biological evaluation of potent EGFR kinase inhibitors against 19D/T790M/C797S mutation	15
Effect of resveratrol on the repair of kidney and brain injuries and its regulation on klotho gene in d-galactose-induced aging mice	15
Lipoate-acid ligase a modification of native antibody: Synthesis and conjugation site analysis	15
Regioselective hemisynthesis and insecticidal activity of C8-hydrazones/acylhydrazones/sulfonylhydrazones coumarin-type derivatives of osthole	15
Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins	15
Phosphonium-ammonium-based di-cationic ionic liquids as antibacterial over the ESKAPE group	15
Identification of a novel orally bioavailable NLRP3 inflammasome inhibitor	15
Cellular and non-target metabolomics approaches to understand the antifungal activity of methylaervine against Fusarium solani	15
Discovery of 3-(benzofuran-2-ylmethyl)-1H-indole derivatives as potential autophagy inducers in cervical cancer cells	15
FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity	15
Anti-inflammatory principles from Lindera aggregata	14
Design, synthesis and biological evaluation of dual mTOR/HDAC6 inhibitors in MDA-MB-231 cells	14
Ansamycin derivatives from the marine-derived Streptomyces sp. SCSGAA 0027 and their cytotoxic and antiviral activities	14
Discovery of clinical candidate Sivopixant (S-600918): Lead optimization of dioxotriazine derivatives as selective P2X3 receptor antagonists	14
Design, synthesis, and biological evaluation of β-carboline 1,3,4-oxadiazole based hybrids as HDAC inhibitors with potential antitumor effects	14
Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer’s disease	14
PARP inhibitor cyanine dye conjugate with enhanced cytotoxic and antiproliferative activity in patient derived glioblastoma cell lines	14
Design and synthesis of a novel class EGFR/HER2 dual inhibitors containing tricyclic oxazine fused quinazolines scaffold	14
Synthesis and evaluation of NLRP3-inhibitory sulfonylurea [11C]MCC950 in healthy animals	14
Synthesis and antifungal activity of new hybrids pyrimido[4,5-d]pyridazinone-N-acylhydrazones	14
Development of a selective HDAC inhibitor aimed at reactivating the HIV latent reservoir	14
Synthesis and biological evaluation of novel 4,7-disubstituted coumarins as selective tumor-associated carbonic anhydrase IX and XII inhibitors	14
Discovery of carbon-11 labeled sulfonamide derivative: A PET tracer for imaging brain NLRP3 inflammasome	14
Discovery of novel VEGFR-2 inhibitors embedding 6,7-dimethoxyquinazoline and diarylamide fragments	14
Free radical scavenging activities of verbascoside and isoverbascoside from the leaves of Odontonema strictum (Acanthaceae)	14
The optimization and characterization of functionalized sulfonamides derived from sulfaphenazole against Mycobacterium tuberculosis with reduced CYP 2C9 inhibition	14
Design, synthesis and antimicrobial activity of novel 2-aminothiophene containing cyclic and heterocyclic moieties	13
Integrating DNA-encoded chemical libraries with virtual combinatorial library screening: Optimizing a PARP10 inhibitor	13
New lead discovery of insect growth regulators based on the scaffold hopping strategy	13
Discovery of highly potent SARS-CoV-2 Mpro inhibitors based on benzoisothiazolone scaffold	13

Discovery of novel Hsp90 C-terminal domain inhibitors that disrupt co-chaperone binding	13
Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV)	13
Radioligands targeting purinergic P2X7 receptor	13
Anti-proliferative potential of triphenyl substituted pyrimidines against MDA-MB-231, HCT-116 and HT-29 cancer cell lines	13
Cytotoxic components from the leaves of Erythrophleum fordii induce human acute leukemia cell apoptosis through caspase 3 activation and PARP cleavage	13
Discovery of novel pyrazolopyrimidine derivatives as potent mTOR/HDAC bi-functional inhibitors via pharmacophore-merging strategy	13
Optimization of globomycin analogs as novel gram-negative antibiotics	13
Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents	13
Novel molecular hybrids of indoline spiropyrans and α-lipoic acid as potential photopharmacological agents: Synthesis, structure, photochromic and biological properties	13
An osteoinductive effect of phytol on mouse mesenchymal stem cells (C3H10T1/2) towards osteoblasts	13
Structure activity study of S-trityl-cysteamine dimethylaminopyridine derivatives as SIRT2 inhibitors: Improvement of SIRT2 binding and inhibition	13
Monovalent protein-degraders – Insights and future perspectives	13
Synthesis and antiproliferative screening of novel doubly modified colchicines containing urea, thiourea and guanidine moieties	13
Synthesis and evaluation of 1,2,4-oxadiazole derivatives as potential anti-inflammatory agents by inhibiting NF-κB signaling pathway in LPS-stimulated RAW 264.7 cells	13
Trans-Pd/Pt(II) saccharinate complexes with a phosphine ligand: Synthesis, cytotoxicity and structure-activity relationship	13
Discovery of 3-aryl substituted benzoxaboroles as broad-spectrum inhibitors of serine- and metallo-β-lactamases	13
Synthesis and biological evaluation of parthenolide derivatives with reduced toxicity as potential inhibitors of the NLRP3 inflammasome	13
In vitro anti-Leishmania activity and molecular docking of spiro-acridine compounds as potential multitarget agents against Leishmania infantum	13
In silico and in vitro screening for potential anticancer candidates targeting GPR120	13
Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors	13
Novel carboxylated pyrroline-2-one derivatives bearing a phenylhydrazine moiety: Design, synthesis, antifungal evaluation and 3D-QSAR analysis	13
Synthesis and biological evaluation of new 2‑substituted‑4‑amino-quinolines and -quinazoline as potential antifungal agents	12
A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar	12
Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators	12
Identification of 2-substituted pyrrolo[1,2-b]pyridazine derivatives as new PARP-1 inhibitors	12
Indolyl-α-keto-1,3,4-oxadiazoles: Synthesis, anti-cell proliferation activity, and inhibition of tubulin polymerization	12
Discovery and optimization of substituted oxalamides as novel heme-displacing IDO1 inhibitors	12
Dithiocarbamate prodrugs activated by prostate specific antigen to target prostate cancer	12
Design, syntheses and evaluations of novel indole derivatives as orally selective estrogen receptor degraders (SERD)	12
Design and synthesis of 4-Aminoquinoline-isoindoline-dione-isoniazid triads as potential anti-mycobacterials	12
Exploring the newer oxadiazoles as real inhibitors of human SIRT2 in hepatocellular cancer cells	12
Fiaud’s Acid, a novel organocatalyst for diastereoselective bis α-aminophosphonates synthesis with in-vitro biological evaluation of antifungal, antioxidant and enzymes inhibition potential	12
Trivalent sulfonium compounds (TSCs): Tetrahydrothiophene-based amphiphiles exhibit similar antimicrobial activity to analogous ammonium-based amphiphiles	12
Synthesis and biofilm inhibition studies of 2-(2-amino-6-arylpyrimidin-4-yl)quinazolin-4(3H)-ones	12
Novel boronium salt exhibits substantial antibacterial activity when compared to a commercial quaternary ammonium disinfectant	12
The synthesis and antituberculosis activity of 5-alkynyl uracil derivatives	12
Design, synthesis and biological evaluation of ring-fused pyrazoloamino pyridine/pyrimidine derivatives as potential FAK inhibitors	12
Influenza antiviral activity of F- and OH-containing isopulegol-derived octahydro-2H-chromenes	12
Cytotoxic effects of the biflavonoids isolated from Selaginella trichoclada on MCF-7 cells and its potential mechanism	12
Synthesis, biological activities, and SAR studies of novel 1-(2-chloro-4,5-difluorophenyl)-1H-pyrazole derivatives	12
Quinazoline Based HSP90 Inhibitors: Synthesis, Modeling Study and ADME Calculations Towards Breast Cancer Targeting	12
Structural investigation on thiazolo[5,4-d]pyrimidines to obtain dual-acting blockers of CD73 and adenosine A2A receptor as potential antitumor agents	12
Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt	12
Circular dichroism spectroscopy of DNA duplexes at near-biological concentrations	12
Synthesis and evaluation of antimycobacterial activity of riboflavin derivatives	12
Design, synthesis and evaluation of novel indirubin-based N-hydroxybenzamides, N-hydroxypropenamides and N-hydroxyheptanamides as histone deacetylase inhibitors and antitumor agents	12
Discovery of heterocyclic carbohydrazide derivatives as novel selective fatty acid amide hydrolase inhibitors: design, synthesis and anti-neuroinflammatory evaluation	12
RNA-Seq based transcriptome analysis reveals the molecular mechanism of triterpenoid biosynthesis in Glycyrrhiza glabra	12
Antifungal trichothecene sesquiterpenes obtained from the culture broth of marine-derived Trichoderma cf. brevicompactum and their structure-activity relationship	12
Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans	12
Synthesis and biological evaluation of heterocyclic bis-aryl amides as novel Src homology 2 domain containing protein tyrosine phosphatase-2 (SHP2) inhibitors	12
SFPH proteins as therapeutic targets for a myriad of diseases	12
DNA aptamers selection for carcinoembryonic antigen (CEA)	12
Discovery of vimseltinib (DCC-3014), a highly selective CSF1R switch-control kinase inhibitor, in clinical development for the treatment of Tenosynovial Giant Cell Tumor (TGCT)	12
Enhancing the activity of membrane remodeling epsin-peptide by trimerization	12
Inhibition of the NorA efflux pump of S. aureus by (Z)-5-(4-Fluorobenzylidene)-Imidazolidines	12
Pre-clinical evidences of the antileishmanial effects of diselenides and selenocyanates	12
Design, synthesis and biological evaluation of 2-aminoquinazolin-4(3H)-one derivatives as potential SARS-CoV-2 and MERS-CoV treatments	12
Design, synthesis and antiproliferative activity evaluation of a series of pyrrolo[2,1-f][1,2,4]triazine derivatives	12
Development of a bioavailable boron-containing PI-103 Bioisostere, PI-103BE	12
Regioselective synthesis and evaluation of 2-amino 3-cyano chromene-chrysin hybrids as potential anticancer agents	11
Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors	11
Discovery of cinnoline derivatives as potent PI3K inhibitors with antiproliferative activity	11
Design and synthesis of pyrazolo[3,4-d]pyrimidinone derivatives: Discovery of selective phosphodiesterase-5 inhibitors	11
Low-dimensional compounds containing bioactive ligands. Part XIV: High selective antiproliferative activity of tris(5-chloro-8-quinolinolato)gallium(III) complex against human cancer cell lines	11
Radiosynthesis and biological evaluation of an fluorine-18 labeled galactose derivative [18F]FPGal for imaging the hepatic asialoglycoprotein receptor	11
Modification of imidazothiazole derivatives gives promising activity in B-Raf kinase enzyme inhibition; synthesis, in vitro studies and molecular docking	11
Pyrazolo[1,5-a]pyrimidine based Trk inhibitors: Design, synthesis, biological activity evaluation	11
Design and synthesis of C-12 dithiocarbamate andrographolide analogues as an anticancer agent	11
2H-1,2,3-Triazole-chalcones as novel cytotoxic agents against prostate cancer	11
Interdiction at a protein-protein interface: MCL-1 inhibitors for oncology	11
Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans	11
Overcoming β-Lactam resistance in Pseudomonas aeruginosa using non-canonical tobramycin-based antibiotic adjuvants	11
Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization	11
Mdm2 inhibitors as a platform for the design of P-glycoprotein inhibitors	11
Design, synthesis and biological evaluation of novel pteridinone derivatives possessing a hydrazone moiety as potent PLK1 inhibitors	11
Synthesis of non-nucleoside anti-viral cyclopropylcarboxacyl hydrazones and initial anti-HSV-1 structure-activity relationship studies	11
Discovery of a novel highly potent broad-spectrum heterocyclic chemical series of arenavirus cell entry inhibitors	11
Lead discovery, chemical optimization, and biological evaluation studies of novel histone methyltransferase SET7 small-molecule inhibitors	11
Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists	11
Evaluation of pyrrolidine-based analog of jaspine B as potential SphK1 inhibitors against rheumatoid arthritis	11
Novel hydrazone derivatives of N-amino-11-azaartemisinin with high order of antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice via intramuscular route	11
Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders	11
Identification of a new class of HBV capsid assembly modulator	11
Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure–activity relationship, in vitro and in vivo evaluation as antitumor agents	11
Synthesis and biological evaluation of backbone-aminated analogues of gramicidin S	11
Substituted benzyloxytricyclic compounds as retinoic acid-related orphan receptor gamma t (RORγt) agonists	11
Development and evaluation of [18F]Flotaza for Aβ plaque imaging in postmortem human Alzheimer’s disease brain	11
Agrochemical properties evaluation of some imines alkaloids of matrine/oxymatrine	11
SARS-CoV-2 main protease inhibition by compounds isolated from Luffa cylindrica using molecular docking	11
Structure based design, synthesis, and biological evaluation of imidazole derivatives targeting dihydropteroate synthase enzyme	11
Selective Wee1 degradation by PROTAC degraders recruiting VHL and CRBN E3 ubiquitin ligases	11
Single-crystal structure and intracellular localization of Zn(II)-thiosemicarbazone complex targeting mitochondrial apoptosis pathways	10
Recent advances toward the development of Hsp90 C-terminal inhibitors	10
Synthesis and in vitro antifungal activity of new Michael-type amino derivatives of xanthatin, a natural sesquiterpene lactone from Xanthium strumarium L.	10