Bioorganic & Medicinal Chemistry Letters

Article	Citations
Graphical abstract TOC	150
Synthesis and SAR of novel GPR39 agonists and positive allosteric modulators	95
Graphical abstract TOC	84
Contents Continued	70
Editorial Board	64
Angucyclines containing β-ᴅ-glucuronic acid from Streptomyces sp. KCB15JA151	63
Discovery of 3-amino-4-{(3S)-3-[(2-ethoxyethoxy)methyl]piperidin-1-yl}thieno[2,3-b]pyridine-2-carboxamide (DS96432529): A potent and orally active bone anabolic agent	50
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype	49
Editorial Board	49
Design of 99mTc-labeled zinc-chelating imaging probe for SPECT imaging of the pancreas	42
Synthesis and biological evaluation of cajanonic acid A derivatives as potential PPARγ antagonists	41
A late-stage diversification via Heck-Matsuda arylation: Straightforward synthesis and cytotoxic/antiproliferative profiling of novel aryl-labdane-type derivatives	41
Graphical abstract TOC	36
Discovery of GNE-502 as an orally bioavailable and potent degrader for estrogen receptor positive breast cancer	35
Design, synthesis and analysis of novel sphingosine kinase-1 inhibitors to improve oral bioavailability	35
Design, synthesis and biological evaluation of 1,3,4-triazole-3-acetamide derivatives as potent neuraminidase inhibitors	34
Discovery of (2-phenylthiazol-4-yl)urea derivatives that induce neuronal differentiation from mesenchymal stem cells	33
Graphical abstract TOC	32
Graphical abstract TOC	32
Discovery of tricyclic HIV-1 integrase-LEDGF/p75 allosteric inhibitors by intramolecular direct arylation reaction	31
Graphical abstract TOC	30
Editorial Board	30
Design and synthesis of unique morphinan-type molecules: Their application to the search for the unexplored binding domain between opioid receptors and morphinan ligands	30
Identification of novel glucocerebrosidase chaperones by unexpected skeletal rearrangement reaction	29
Graphical abstract TOC	29

Green synthesis and anti-biofilm activities of 3,5-disubstituted isoxazoline/isoxazole-linked secondary sulfonamide derivatives on Pseudomonas aeruginosa	29
Graphical Abstract Contents Continued	28
Discovery of SHR5428 as a selective and noncovalent inhibitor of CDK7	28
Editorial Board	28
Graphical abstract TOC	26
Virtual screening for early identification of potent and selective histone deacetylase 6 inhibitor series	26
Calcitonin gene-related peptide (CGRP) receptor antagonists: Heterocyclic modification of a novel azepinone lead	26
Synthesis and human monoamine oxidase inhibitory activity of novel C2-, C3- and C4-substituted phthalonitriles	25
Graphical abstract TOC	25
Potential of several triazene derivatives against DENGUE viruses	25
Discovery of structural diverse reversible BTK inhibitors utilized to develop a novel in vivo CD69 and CD86 PK/PD mouse model	25
A survey of the clinical pipeline in neuroscience	25
Editorial Board	23
Graphical Abstract Contents Continued	23
11C-Labeling of acyclic retinoid peretinoin by rapid C-[11C]methylation to disclose novel brain permeability and central nervous system activities hidden in antitumor agent	23
Graphical abstract TOC	22
Graphical abstract TOC	22
Bicyclic pyrimidine compounds as potent IRAK4 inhibitors	22
SolS-catalyzed sulfoxidation of labionin to solabionin drives antibacterial activity of solabiomycins	21
Synthesis and properties of a novel modified nucleic acid, 2′-N-methanesulfonyl-2′-amino-locked nucleic acid	21
Identification of novel gankyrin binding scaffolds by high throughput virtual screening	21
Characterization of the G-quadruplexes in the transthyretin gene and its role in silencing transthyretin mRNA transcription	20
Synthesis of pyrrolo[3,2-d]pyrimidineone derivatives as novel FXa inhibitors	20
Editorial Board	20
Editorial Board	20
Graphical abstract TOC	20
Cancer cell growth suppressibility of ω-3 fatty acid whose carboxy group converted to ester group	19
Graphical abstract TOC	19
Design, synthesis and characterizations of prodrugs of brexanolone	19
Editorial Board	19
Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)	19
Structure-based design of novel melanin-concentrating hormone receptor-1 ligands based on saturated nitrogen-containing heterocycles	18
Design and synthesis of aminopyridine containing biaryls reducing c-MYC protein levels in cells	18
Graphical abstract TOC	18
Graphical abstract TOC	18
Graphical abstract TOC	18
Graphical Abstract TOC	18
Graphical abstract TOC	18
Graphical Abstract Contents Continued	18
Targeting ATP-binding site of WRN Helicase: Identification of novel inhibitors through pocket analysis and Molecular Dynamics-Enhanced virtual screening	17
Regioselective hemisynthesis and insecticidal activity of C8-hydrazones/acylhydrazones/sulfonylhydrazones coumarin-type derivatives of osthole	17
FFAR1/GPR40: One target, different binding sites, many agonists, no drugs, but a continuous and unprofitable tug-of-war between ligand lipophilicity, activity, and toxicity	17
Pyrazolo-1-carbothioamides as EGR-1–DNA binding disruptors	17
Disrupted target binding with acryloyl group as potential Bcr-Abl/C-Src dual kinase inhibitor optimization strategies with maintained antitumor activity	17
Indolyl-α-keto-1,3,4-oxadiazoles: Synthesis, anti-cell proliferation activity, and inhibition of tubulin polymerization	17
Graphical abstract TOC	17
Synthesis, anti-microbial, toxicity and molecular docking studies of N-nitroso-N-phenylhydroxylamine (cupferron) and its derivatives	17
Lead optimization of cathepsin K inhibitors for the treatment of Osteoarthritis	17
Synthesis of 1-(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazol-3-yl)-2-morpholinoethane-1,2-dione analogues and their inhibitory activities with reduced cytotoxicity in lipopolysacchari	16
Discovery of DS-1093a: An oral hypoxia-inducible factor prolyl hydroxylase inhibitor for the treatment of renal anemia	16

Synthesis and preliminary biological evaluation of a novel 99mTc-labeled small molecule for PD-L1 imaging	16
The discovery of BMS-737 as a potent, CYP17 lyase-selective inhibitor for the treatment of castration-resistant prostate cancer	16
Holistic drug design for multiparameter optimization in modern small molecule drug discovery	16
Design, synthesis and evaluation of new pyrimidine derivatives as EGFRC797S tyrosine kinase inhibitors	16
Discovery and characterization of novel TRPML1 agonists	16
Synthesis of baicalein derivatives and evaluation of their antiviral activity against arboviruses	16
Retraction notice to “Synthesis, carbonic anhydrase enzyme inhibition evaluations, and anticancer studies of sulfonamide based thiadiazole derivatives” [BMCL 57 (2022) 128520]	16
A conformationally-locked p-hydroxybenzylidene imidazolinone derivative for detecting Aβ42 aggregation	16
Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton	15
Editorial Board	15
Non-alkylator anti-glioblastoma agents induced cell cycle G2/M arrest and apoptosis: Design, in silico physicochemical and SAR studies of 2-aminoquinoline-3-carboxamides	15
Graphical abstract TOC	15
Synthesis and in vitro antifungal activity of new Michael-type amino derivatives of xanthatin, a natural sesquiterpene lactone from Xanthium strumarium L.	15
Contents continued	15
Design, synthesis and antibacterial activity against pathogenic mycobacteria of conjugated hydroxamic acids, hydrazides and O-alkyl/O-acyl protected hydroxamic derivatives	15
Brain-penetrant cyanoindane and cyanotetralin inhibitors of G2019S-LRRK2 kinase activity	15
Synthesis and biological evaluation of niclosamide PROTACs	15
New class of fused [3,2-b][1,2,4]triazolothiazoles for targeting glioma in vitro	15
Identification of covalent fragment inhibitors for Plasmodium falciparum UCHL3 with anti-malarial efficacy	15
Promising anti-SARS-CoV-2 drugs by effective dual targeting against the viral and host proteases	14
2-[(2-Amino-6-methylpyrimidin-4-yl)sulfanyl]-N-arylacetamides: Discovery of a new class of anti-tubercular agents and prospects for their further structural modification	14
Discovery of 1,2,3-triazole-based pleuromutilin derivatives as potent gram-positive antibacterial agents	14
Towards the enzymatic synthesis of phosphorothioate containing LNA oligonucleotides	14
Discovery of novel oridonin sulfamide derivatives as potent NLRP3 inhibitors by a visible-light photocatalysis-enabled peripheral editing	14
Design and synthesis, biological evaluation of bis-(1,2,3- and 1,2,4)-triazole derivatives as potential antimicrobial and antifungal agents	14
Targeting epigenetic modulators using PROTAC degraders: Current status and future perspective	14
SARS-CoV-2 papain-like protease (PLpro) inhibitory and antiviral activity of small molecule derivatives for drug leads	14
Repurposing old drugs as novel inhibitors of human MIF from structural and functional analysis	14
Design, synthesis and antibacterial evaluation of novel 3-O-substituted 15-membered azalides possessing 1,2,3-triazole side chains	14
Targeting G-quadruplexes to achieve antiviral activity	14
Emodin lows NPC1L1-mediated cholesterol absorption as an uncompetitive inhibitor	14
Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC	13
Design, synthesis, and biological evaluation of chalcone acetamide derivatives against triple negative breast cancer	13
Design and structural optimization of thiadiazole derivatives with potent GLS1 inhibitory activity	13
Boronic acid derivative activates pyruvate kinase M2 indispensable for redox metabolism in oral cancer cells	13
Evaluation of darunavir-derived HIV-1 protease inhibitors incorporating P2′ amide-derivatives: Synthesis, biological evaluation and structural studies	13
Design, synthesis and anti-tumor evaluation of plinabulin derivatives as potential agents targeting β-tubulin	13
Discovery and antiviral profile of new sulfamoylbenzamide derivatives as HBV capsid assembly modulators	13
Novel 2,4-disubstituted quinazoline analogs as antibacterial agents with improved cytotoxicity profile: Modification of the benzenoid part	13
Efficiency of bis-amidate phosphonate prodrugs	13
Design and development of 1,3,5-triazine derivatives as protective agent against spinal cord injury in rat via inhibition of NF-ĸB	13
Synthesis and antifungal evaluation of phenol-derived bis(indolyl)methanes combined with FLC against Candida albicans	13
Synthesis of the analogs of plocabulin and their preliminary structure-activity relationship study	13
Discovery of 5-methyl-1H-benzo[d]imidazole derivatives as novel P2X3 Receptor antagonists	13
A concise review on marine bromopyrrole alkaloids as anticancer agents	13
Exploration of 4-(1H-indol-3-yl)cyclohex-3-en-1-amine analogues as HDAC inhibitors: Design, synthesis, biological evaluation and modelling studies	13
Armeniaspirol analogues disrupt the electrical potential (ΔΨ) of the proton motive force	13
Design, synthesis and assessment of new series of quinazolinone derivatives as EGFR inhibitors along with their cytotoxic evaluation against MCF7 and A549 cancer cell lines	13
Discovery and SAR of 4-aminopyrrolidine-2-carboxylic acid correctors of CFTR for the treatment of cystic fibrosis	13
Phytochemical investigation of Asarum sieboldii var. seoulense and the phenotypic profiles of its constituents against a Parkinson’s Disease olfactory cell line	13
Discovery of N-(6-(5-fluoro-2-(piperidin-1-yl)phenyl)pyridazin-3-yl)-1-(tetrahydro-2H-pyran-4-yl)methanesulfonamide as a brain-permeable and metabolically stable kynurenine monooxygenase inhibitor	13
Design, Synthesis, anti-inflammatory activity Evaluation, preliminary exploration of the Mechanism, molecule Docking, and structure-activity relationship analysis of batatasin III analogs	12
Cage hydrocarbons as linkers in dimeric drug design: Case studies with trimethoprim and tedizolid	12
Design, synthesis and evaluation of 2-(2-oxoethyl)pyrimidine-5-carboxamide derivatives as acetylcholinesterase inhibitors	12
Design and evaluation of anaplastic lymphoma kinase degraders using a covalent fumarate handle	12
The development of diphenyleneiodonium analogs as GPR3 agonists	12
Small molecule approaches to treat autoimmune and inflammatory diseases (Part I): Kinase inhibitors	12
Polyheterocyclic peptidomimetics: Parallel solid phase synthesis of oligo cyclic guanidines and their inhibition activity against Mycobacterium tuberculosis DNA gyrase	12
Synthesis and biological evaluation of novel SN38-glucose conjugate for colorectal cancer treatment	12
Design, synthesis and structure-activity relationship of malonic acid non-nucleoside derivatives as potent CD73 inhibitors	12
Persistent challenges in the development of an mGlu7 PAM in vivo tool compound: The discovery of VU6046980	12
Revisiting the dipeptidyl carboxypeptidase inhibitor captopril as a source of pan anti-trypanosomatid agents	12
Optimization of 3-aminotetrahydrothiophene 1,1-dioxides with improved potency and efficacy as non-electrophilic antioxidant response element (ARE) activators	12
Discovery of 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine derivatives as novel selective Axl inhibitors	12
Novel hydrazone derivatives of N-amino-11-azaartemisinin with high order of antimalarial activity against multidrug-resistant Plasmodium yoelii nigeriensis in Swiss mice via intramuscular route	12
Proline based rationally designed peptide esters against dipeptidyl peptidase-4: Highly potent anti-diabetic agents	12
Synthesis and biological activity evaluation of novel 3,5,7-trisubstituted pyrazolo[1,5-a]pyrimidines	12
Split luciferase-based estimation of cytosolic cargo concentration delivered intracellularly via attenuated cationic amphiphilic lytic peptides	12
A 2′-modified uridine analog, 2′-O-(methylthiomethoxy)methyl uridine, for siRNA applications	12
Enteroviral replication inhibition by N-Alkyl triazolopyrimidinone derivatives through a non-capsid binding mode	12
Discovery of quinuclidine modulators of cellular progranulin	12
Conserved gatekeeper methionine regulates the binding and access of kinase inhibitors to ATP sites of MAP2K1, 4, and 7: Clues for developing selective inhibitors	12
Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site	12
Novel PEGylated derivatives of α-tocopherol for nanocarrier formulations; synthesis, characterization and in vitro cytotoxicity against MCF-7 breast cancer cells	11
Inhibitory effects and mechanism of antifungal action of the natural cyclic depsipeptide, aureobasidin A against Cryptococcus neoformans	11
Regulation of CD28 binding to SH2 domains of Grb2 and PI3K by trisubstituted carboranes for T-cell activation	11
Discovery and characterization of a novel glucose-6-phosphate dehydrogenase (G6PD) inhibitor via high-throughput screening	11
Synthesis and antibacterial activities of marine natural product ianthelliformisamines and subereamine synthetic analogues	11
Substituent effects of cyclic naphthalene diimide on G-quadruplex binding and the inhibition of cancer cell growth	11
Novel molecule combinations and corresponding hybrids targeting artemisinin-resistant Plasmodium falciparum parasites	11

Chromenone: An emerging scaffold in anti-Alzheimer drug discovery	11
Discovery of a novel inhibitor of nitric oxide production with potential therapeutic effect on acute inflammation	11
Therapeutic potential of Coumarin-polyphenolic acid hybrids in PD: Inhibition of α-Syn aggregation and disaggregation of preformed fibrils, leading to reduced neuronal inclusion formation	11
Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors	11
Structure–activity relationship study of nitrogen signaling factors	11
Promising hit compounds against resistant trichomoniasis: Synthesis and antiparasitic activity of 3-(ω-aminoalkoxy)-1-benzyl-5-nitroindazoles	11
Synthesis of polyenylpyrrole derivatives with selective growth inhibitory activity against T-cell acute lymphoblastic leukemia cells	11
Discovery of an indole-substituted furanone with tubulin polymerization inhibition activity	11
Design, synthesis and preliminary bioactivity evaluation of bitopic benzopyranomorpholine analogues as selective dopamine D3 receptor ligands as anti-drug addiction therapeutic agents	11
Discovery of sertraline and its derivatives able to combat drug-resistant gastric cancer cell via inducing apoptosis	11
Lipid bilayer membrane permeability mechanism of the K-Ras(G12D)-inhibitory bicyclic peptide KS-58 elucidated by molecular dynamics simulations	11
Development of a highly potent and selective degrader of LRRK2	11
Discovery of novel Staphylococcus aureus penicillin binding protein 2a inhibitors by multistep virtual screening and biological evaluation	11
Natural-product-based pesticides: Semisynthesis, structural elucidation, and evaluation of new cholesterol–matrine conjugates as pesticidal agents	11
Synthesis of K+ channel radioligand [18F]5-methyl-3-fluoro-4-aminopyridine and PET imaging in mice	11
Synthesis and anti-trypanosomal activity of 3′-fluororibonucleosides derived from 7-deazapurine nucleosides	11
Synthesis of xanthosine 2-phosphate diesters via phosphitylation of the carbonyl group	11
Extended voltage imaging in cardiomyocytes with a triplet state quencher-stabilized silicon rhodamine	11
Identification of N-(((1S,3R,5S)-adamantan-1-yl)methyl)-3-((4-chlorophenyl)sulfonyl)benzenesulfonamide as novel Nav1.8 inhibitor with analgesic profile	11
Synthesis, SARS-CoV-2 main protease inhibition, molecular docking and in silico ADME studies of furanochromene-quinoline hydrazone derivatives	11
Epigallocatechin and epigallocatechin-3-gallate are not inhibitors of tyrosinase	11
Synthetic enamine naphthoquinone derived from lawsone as cytotoxic agents assessed by in vitro and in silico evaluations	10
Synthesis and analysis of novel catecholic ligands as inhibitors of catechol-O-methyltransferase	10
Design, synthesis of auristatins-glucuronide conjugates targeting the β-glucuronidase in tumor microenvironment	10
Design, synthesis and biological evaluation of dual mTOR/HDAC6 inhibitors in MDA-MB-231 cells	10
In vitro and in vivo neuroprotective effect of novel mPGES-1 inhibitor in animal model of Parkinson’s disease	10
Identification of benzothiazoles as novel PCSK9 inhibitors	10
Truncated derivatives of amphidinol 3 reveal the functional role of polyol chain in sterol-recognition and pore formation	10
Identification of highly potent and selective HTRA1 inhibitors	10
Exploring boron applications in modern agriculture: A structure-activity relationship study of a novel series of multi-substitution benzoxaboroles for identification of potential fungicides	10
Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators	10
Progress of tubulin polymerization activity detection methods	10
Synthesis of novel 1H-Pyrazolo[3,4-b]pyridine derivatives as DYRK 1A/1B inhibitors	10
Structure-property and structure–activity relationships of phenylferrocene derivatives as androgen receptor antagonists	10
Functionalization of β-cyclodextrin with a urea-based PSMA ligand and preliminary studies on targeting prostate cancer cells	10
Antimicrobial, modulatory, and antibiofilm activity of tt-farnesol on bacterial and fungal strains of importance to human health	10
Discovery of 4-phenylindolines containing a (5-cyanopyridin-3-yl)methoxy moiety as potent inhibitors of the PD-1/PD-L1 interaction	10
Design, synthesis and structure-activity relationship of 1,8-naphthalimide derivatives as highly potent hCYP1B1 inhibitors	10
Design, synthesis, and anti-influenza A virus activity evaluation of novel indole containing derivatives of triazole	10
Discovery of 4-(phenoxymethyl)-1H-1,2,3-triazole derivatives as novel xanthine oxidase inhibitors	10
Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice	10
Synthesis and biological evaluation of bi-modal BODIPY-conjugated Hoechst applicable for Auger-electron and photodynamic cancer therapy	10
Improved synthesis and anticancer activity of a potent neuronal nitric oxide synthase inhibitor	10
Design, synthesis, and biological testing of biphenylmethyloxazole inhibitors targeting HIV-1 reverse transcriptase	10
Green synthesis of nitroaryl thioureas: Towards an improved preparation of guanidinium DNA binders	10
A fluorescent molecular rotor for the selective detection of the hybrid-conformation 22AG G-Quadruplex	10
Enantiomeric profiling of a chiral benzothiazole necroptosis inhibitor	10
Design, synthesis, and biological evaluation of novel covalent inhibitors targeting focal adhesion kinase	10
Modification of the phenyl ring B of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site	10
Corrigendum to “Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids” [Bioorg. Med. Chem. Lett. 27(18) (2017) 4358–4369]	9
Anti-chronic myeloid leukemia activity and quantitative structure-activity relationship of novel thiazole aminobenzamide derivatives	9
Discovery of 2-thiobenzimidazoles as noncovalent inhibitors of SARS-CoV-2 main protease	9
Novel carbohydrate-based sulfonamide derivatives as selective carbonic anhydrase II inhibitors: Synthesis, biological and molecular docking analysis	9
Novel 1-(prop-2-yn-1-ylamino)-2,3-dihydro-1H-indene-4-thiol derivatives as potent selective human monoamine oxidase B inhibitors: Design, SAR development, and biological evaluation	9
Design, synthesis and antitumor activity of phthalazine-1,4-dione-based menaquinone analogs	9
The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase	9
Design, synthesis and biological evaluation of alginate oligosaccharide derivatives	9
Enzymatic transformation of esculetin as a potent class of α-glucosidase inhibitors	9
Design, synthesis, and bioactivity evaluation of macrocyclic benzo[b]pyrido[4,3-e][1,4]oxazine derivatives as novel Pim-1 kinase inhibitors	9
Design, synthesis, and biological evaluation of phenyl thiazole-based AR-V7 degraders	9
Total synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy	9
[99mTc]Tc-labeled HYNIC conjugated chlorambucil as a tumor targeting Agent: Synthesis, characterization and ex-vivo evaluation	9
WITHDRAWN: Discovery of indoline derivatives as anticancer agents via inhibition of tubulin polymerization	9
Chemical proteomic analysis of palmostatin beta-lactone analogs that affect N-Ras palmitoylation	9
Elucidation of structure-activity relationship of humulanolides and identification of humulanolide analog as a novel HSP90 inhibitor	9
Photochemical transformation of a cellulose biosynthesis inhibitor into phytoene desaturase inhibitors	9
Design and synthesis of novel diosgenin-triazole hybrids targeting inflammation as potential neuroprotective agents	9
Synthesis and biological evaluation of novel 18F-labeled phenylbenzofuran-2-carboxamide derivative for detection of orexin 1 receptor in the brain	9
Synthesis and fungicidal activity of novel 2-(2-alkylthio-6-phenylpyrimidin-4-yl)-1H-benzimidazoles	9
Mur ligases inhibitors with azastilbene scaffold: Expanding the structure–activity relationship	9
Design, synthesis and anti-tumor activity studies of novel pyrido[3, 4-d]pyrimidine derivatives	9
Design, synthesis and biological evaluation of quinazoline SOS1 inhibitors	9
Bacterial GTPases as druggable targets to tackle antimicrobial resistance	9
Microwave assisted regioselective synthesis of quinoline appended triazoles as potent anti-tubercular and antifungal agents via copper (I) catalyzed cycloaddition	9
Rational design, synthesis and pharmacological characterization of novel aminopeptidase A inhibitors	9
A PSMA-targeted doxorubicin small-molecule drug conjugate	9
Neuropilin 1-targeted near-infrared fluorescence probes for tumor diagnosis	9
Lipophilic quinolone derivatives: Synthesis and in vitro antibacterial evaluation	9
Isolation, synthesis and absolute configuration of 4,5-dihydroxypiperines improving behavioral disorder in AlCl3-induced dementia	9
Synthesis and activity of N-(5-hydroxy-3,4,6-trimethylpyridin-2-yl)acetamide analogues as anticolitis agents via dual inhibition of TNF-α- and IL-6-induced cell adhesions	9
The ester derivatives obtained by C-ring modification of podophyllotoxin induce apoptosis and inhibited proliferation in PC-3M cells via down-regulation of PI3K/Akt signaling pathway	9
Natural aloe emodin-hybridized sulfonamide aminophosphates as novel potential membrane-perturbing and DNA-intercalating agents against Enterococcus faecalis	9
Design and synthesis of novel antioxidants derived from chalcones and their protective effects on cardiomyocytes by activating Nrf2/HO-1 pathway	9
Switching off cancer – An overview of G-quadruplex and i-motif functional role in oncogene expression	9
Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study	9
Design, synthesis and biological evaluation of tanshinone IIA derivatives as NLRP3 inflammasome inhibitors	9
Design, synthesis and human carbonic anhydrase I, II, IX and XII inhibitory properties of 1,3-thiazole sulfonamides	9
Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer’s disease	8
Two cationic meso-thiophenium porphyrins and their zinc-complexes as anti-HIV-1 and antibacterial agents under non-photodynamic therapy (PDT) conditions	8
Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1	8
Discovery of novel pyridine skeleton derivatives as potent CLK2/3 inhibitors	8
A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation	8
Development of LM-41 and AF-2112, two flufenamic acid-derived TEAD inhibitors obtained through the replacement of the trifluoromethyl group by aryl rings	8
Angiokinase inhibition of VEGFR-2, PDGFR and FGFR and cell growth inhibition in lung cancer: Design, synthesis, biological evaluation and molecular docking of novel azaheterocyclic coumarin derivative	8
Discovery of imidazo[1,2-b]pyridazine macrocyclic derivatives as novel ALK inhibitors capable of combating multiple resistant mutants	8