Trends in Cell Biology

Article	Citations
Advisory Board and Contents	663
An ATM D-compartmentalization in DNA damage response	562
Understanding human embryogenesis by building programmable stem cell-based models	416
HELLS: the transcriptional sentinel	385
Centrosomes and cancer: balancing tumor-promoting and inhibitory roles	295
Unlocking Latin America´s scientific potential: challenges and opportunities in a globalized world	287
KCTD10 resolves co-directional transcription–replication conflicts	259
(Alternative) transcription start sites as regulators of RNA processing	223
Modulating cell-free DNA biology as the next frontier in liquid biopsies	200
Translation is an emerging constraint on protein homeostasis in ageing	190
Plasticity of cancer invasion and energy metabolism	186
The bidirectional relationship between metabolism and cell cycle control	186
H3K9 trimethylation homeostasis: mechanisms, crosstalk, and cancer relevance	152
Subscription and Copyright Information	150
Advisory Board and Contents	149
Subscription and Copyright Information	147
Where protein structure and cell diversity meet	147
Olfaction: an emerging regulator of longevity and metabolism	141
Regulation of lipid droplet dynamics and lipid homeostasis by hydroxysteroid dehydrogenase proteins	141
Bucket lists must be completed during cell death	133
Membrane curvature at the ER–PM contact sites	133
Opportunities and challenges for deep learning in cell dynamics research	129
Lysosome: a critical hub for ferroptosis regulation	128
Whi3key old fashioned: a condensate cocktail for cell fate decisions	121
What makes genes burst	109

The multifaceted mitochondrial OXA insertase	107
Cytoplasmic mtDNA clearance suppresses inflammatory immune responses	105
Optical tweezers across scales in cell biology	103
Cultured meat: creative solutions for a cell biological problem	97
Subscription and Copyright Information	94
The promiscuous ribosomal P-stalk: a new functional portrait	91
AMPK: a master regulator of mitochondrial quality and quantity	91
DDX47 untangles R-loops with only certain other helicases	90
Bioelectric regulation of intestinal stem cells	88
Progress and limitations in engineering cellular adhesion for research and therapeutics	87
Optimality as a framework for understanding developmental robustness	87
POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer	87
Lessons in longevity from blood stem cells under protein stress	85
Sublethal engagement of apoptotic pathways in residual cancer	85
tRNA modifications: insights into their role in human cancers	82
The emergence of the stem cell niche	82
Deciphering the significance of p53 mutant proteins	79
Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import	79
Multifaceted mitochondrial quality control in brown adipose tissue	78
Advisory Board and Contents	77
Visualizing intracellular target antigens in live cells	77
Reimagining journal clubs for inclusive scientific training	76
Advisory Board and Contents	75
Moonlighting translation factors: multifunctionality drives diverse gene regulation	72
Self-inflicted DNA breaks in cell differentiation and cancer	71
Wnt signalling in cell division: from mechanisms to tissue engineering	70
Accessible high-speed image-activated cell sorting	70
Mitochondrial transfer at the crossroads of cancer, stromal, and immune cells	70
Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer	68
Tumor–stromal metabolic crosstalk in pancreatic cancer	67
Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy	67
Fun in the sun: ribosomes defend against UV irradiation	64
Reprogramming transcription after DNA damage: recognition, response, repair, and restart	64
Young researchers series #3	64
Advisory Board and Contents	63
Advisory Board and Contents	60
Subscription and Copyright Information	60
Advisory Board and Contents	60
Advisory Board and Contents	56
Young researchers series #7	56
Telomere dynamics as mediators of gut microbiota–host interactions	56
Meiotic spindle pushed outward by inward organelle packing	56
Embryos burn fat in standby	55
Thermoporter: a new regulatory mechanism for mitochondrial calcium uniporter activity	54
Subscription and Copyright Information	54
Transcription-coupled repair of DNA–protein crosslinks	53
ERMCS Ca2+ transmission fuels cell division	52
Crashing by design: Utilizing DNA damage for MCC differentiation	51
The astrocytic connectome: Gap-Junction topology beyond diffuse syncytium	51
Targeting SHP1 and SHP2 to suppress tumors and enhance immunosurveillance	50

Filopodia: integrating cellular functions with theoretical models	50
Membrane remodeling and trafficking piloted by SARS-CoV-2	49
Nascent peptides emerge as regulators of mRNA stability	49
Unique architectural features of mammalian mitochondrial protein synthesis	48
Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia	48
Advisory Board and Contents	47
Advisory Board and Contents	47
Orientational cell adhesions (OCAs) for tissue morphogenesis	46
Subscription and Copyright Information	46
Cell cycle regulation by the ribotoxic stress response	46
Order from chaos: cellular asymmetries explained with modelling	46
Oxidative DNA damage and repair at non-coding regulatory regions	46
Expanding roles of N-glycosylation in the endoplasmic reticulum	46
ER: a critical hub for STING signaling regulation	45
Phase separation on microtubules: from droplet formation to cellular function?	45
Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation	45
Patterns in the tapestry of chromatin-bound RB	44
The idiosyncrasies of oocytes	44
Bridging oxidative post-translational modifications to biological meaning	44
Bloodhounds chasing the origin of blood cells	42
Regulation of gene expression by glycolytic and gluconeogenic enzymes	42
Cellular mechanics during division of a genomically minimal cell	42
Disruption of lineage integrity as a precursor to breast tumor initiation	42
Young researchers series #6	42
Lysosomal enzyme trafficking: from molecular mechanisms to human diseases	41
Sugar symphony: glycosylation in cancer metabolism and stemness	41
Mechanical regulation of cell-cycle progression and division	41
Versatility of gasdermin D beyond pyroptosis	41
Subscription and Copyright Information	40
Subscription and Copyright Information	40
Advisory Board and Contents	39
Advisory Board and Contents	39
Subscription and Copyright Information	39
Subscription and Copyright Information	39
Creating inclusive environments in cell biology by casual mentoring	38
The neuronal-like behaviour of macrophages	38
Death by ribosome	38
Extracellular vesicle-mediated crosstalk in tumor microenvironment dominates tumor fate	36
Spermidine – an old molecule with a new age-defying immune function	35
The peroxisome: an up-and-coming organelle in immunometabolism	35
Immune surveillance of senescence: potential application to age-related diseases	35
New job for an old tool: PI3Kβ phosphorylates OGT to regulate acetyl-CoA in glioblastoma	35
Lysosomes join the circular RNA decay machinery	34
The adipocyte supersystem of insulin and cAMP signaling	34
Stress-induced cell depolarization through the MAP kinase–Cdc42 axis	33
CS proteins and ubiquitination: orchestrating DNA repair with transcription and cell division	33
Subscription and Copyright Information	33
Targeting mitochondrial dynamics against cancer	32
Quality control of mitochondrial nucleoids	31
Ruptoblasts: Explosive cytotoxicity from an ancient lineage	31
Muscle is a stage, and cells and factors are merely players	31
The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond	31
The ubiquitin–proteasome system links NADPH metabolism to ferroptosis	31
ER remodeling via lipid metabolism	31
Changing the culture for the future: time to take brain drain in academics seriously	31
The epigenetic landscape of mesenchymal stem cell and extracellular vesicle therapy	30
Subscription and Copyright Information	30
The Cys/N-degron pathway in the ubiquitin–proteasome system and autophagy	30
Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications	30
Chromatin-interacting RNA-binding proteins regulate transcription	29
Subscription and Copyright Information	29
Molecular mechanisms of nucleolar DNA damage checkpoint response	28
Advisory Board and Contents	28
Tumor-initiating cells establish a niche to overcome isolation stress	28
Advisory Board and Contents	27
Advisory Board and Contents	27
Glucose metabolism of TAMs in tumor chemoresistance and metastasis	26
Metabolic regulation of mRNA splicing	26
Emerging roles of intratumor microbiota in cancer metastasis	26
Regulated circRNA nuclear export in neuronal differentiation	26
The heterogeneity of cellular senescence: insights at the single-cell level	26
The value of a shared lab: Our insights	26
The Warburg effect: a signature of mitochondrial overload	25
3′UTR heterogeneity and cancer progression	25
Phase separation of p62: roles and regulations in autophagy	25
Decoding human cardiovascular development and disease through single-cell transcriptomic and epigenomic profiling	24
Fumarate hydratase as a metabolic regulator of immunity	24
Subscription and Copyright Information	24
Extracellular vesicles from the dead: the final message	23
RNA G-quadruplexes and stress: emerging mechanisms and functions	23

The autophagy–NAD axis in longevity and disease	23
Hard to handle: how lipid saturation affects the nuclear envelope	22
Novel imaging methods and force probes for molecular mechanobiology of cytoskeleton and adhesion	22
TFEB links the cGAS-STING pathway to lysosome biogenesis	22
Subscription and Copyright Information	22
ATRX loss induces lineage plasticity and squamous-like phenotype to promote colorectal cancer metastasis	22
Technological and computational advances driving high-throughput oncology	22
Advisory Board and Contents	22
Regulation of leukemogenesis via redox metabolism	21
Time matters: the dynamics of plasma membrane repair	21
Multifaceted collagen-DDR1 signaling in cancer	21
A 2026 perspective on neural stem cells and glial plasticity	20
Subscription and Copyright Information	20
Mechanism-aware and multimodal AI: beyond model-agnostic interpretation	20
Neutral lipid quality control gates ferroptotic cell death	20
DNA single-strand break repair and human genetic disease	20
Celebrating 35 years of Trends in Cell Biology and introducing our special issue on ribosomal dynamics and cellular homeostasis	20
Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production	20
Subscription and Copyright Information	20
Clonal hematopoiesis and inflammation – the perpetual cycle	20
The role of the immune tumor microenvironment in shaping metastatic dissemination, dormancy, and outgrowth	19
Ferroptosis: mechanisms and implications for cancer development and therapy response	19
Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations	19
Ferroptosis as an approach to leverage cancer metabolism	19
Advisory Board and Contents	18
Implementing standardized diversity, equity, and inclusion approaches within scientific communities	18
Reflected stemness as a potential driver of the tumour microenvironment	18
Where you start could determine where you end up	18
Hypoxia-specific transcriptional condensates drive metastasis	18
Multiplicity of stem cell memories of inflammation and tissue repair in epithelia	18
Spotlighting adult stem cells: advances, pitfalls, and challenges	17
Extracellular matrix remodeling facilitates obesity-associated cancer progression	17
The culture and application of circulating tumor cell-derived organoids	17
Mitochondrial substrate oxidation regulates distinct cell differentiation outcomes	17
The role of RAS oncogenes in controlling epithelial mechanics	17
A novel superfamily of bridge-like lipid transfer proteins	17
The initiation of mammalian embryonic transcription: to begin at the beginning	17
Orchestrating the signaling-bias at the protease-activated receptor, PAR1	17
Mechanisms of cellular mRNA transcript homeostasis	17
The enigmatic roles of epithelial gasdermin B: Recent discoveries and controversies	17
Subscription and Copyright Information	16
Coordinated in confined migration: crosstalk between the nucleus and ion channel-mediated mechanosensation	16
Newly identified cell types crucial for gut commensal tolerance	16
Lysosomal microautophagy: an emerging dimension in mammalian autophagy	16
Cholesterol metabolism regulates macrophage function and inflammation-related diseases	16
Organelle-specific signaling of cGAS–STING	16
Experimental evolution for cell biology	16
MDM4 exon skipping upon dysfunctional ribosome assembly	15
PYK2, a hub of signaling networks in breast cancer progression	14
Time as a danger signal promoting G1 arrest after mitosis	14
Inter-membrane control of junctional InsP3 receptors by PIP2	14
miRNA dosage control in development and human disease	13
Vimentin at the core of wound healing	13
3D genome folding in epigenetic regulation and cellular memory	13
Cullin–RING receptors in rare disease biology	13
The cell biology of APOE in the brain	13
NADH reductive stress drives metabolic reprogramming	13
CDK11, a splicing-associated kinase regulating gene expression	13
Roles of YAP/TAZ in ferroptosis	13
Mechanobiology of organelles: illuminating their roles in mechanosensing and mechanotransduction	13
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective	13
Experimental tools and emerging principles of organellar mechanotransduction	12
Is clathrin a membrane fission protein?	12
Plasma membrane damage is a new trigger of cellular senescence	12
Emerging roles of olfactory receptors in glucose metabolism	12
Central role of the ER proteostasis network in healthy aging	12
Advisory Board and Contents	12
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity	12
Nuclear speckles: a fundamental layer of gene regulation	12
The ins-and-outs of exosome biogenesis, secretion, and internalization	12
Advisory Board and Contents	12
Triple threat: neutrophil ER stress, NETosis, airway inflammation escalation	12
Regulatory landscape of enhancer-mediated transcriptional activation	12
Subscription and Copyright Information	11
Metabolism and HSC fate: what NADPH is made for	11
Transsulfuration, minor player or crucial for cysteine homeostasis in cancer	11
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Integrating mechanical signals into cellular identity	11
Advisory Board and Contents	11
Phenotypic plasticity during metastatic colonization	10
Nutrient availability as an arbiter of cell size	10
Autophagosomal components recycling on autolysosomes	10
Metabolism and mRNA translation: a nexus of cancer plasticity	10
Navigating AKT-ivity across cellular compartments	10
Is euchromatin really open in the cell?	10
Towards solving the mystery of peroxisomal matrix protein import	9
The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development	9
Advisory Board and Contents	9
How it feels in a cell	9
Advisory Board and Contents	9
Mitochondria in cancer stem cells: Achilles heel or hard armor	9
Role of lipids in interorganelle communication	9
Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis	9
The yin and yang of nuclear envelope breakdown through the activity of phosphatase holoenzyme PP2A-B55SUR-6	9
Advisory Board and Contents	9