Trends in Cell Biology

Article	Citations
Advisory Board and Contents	622
An ATM D-compartmentalization in DNA damage response	515
Translation is an emerging constraint on protein homeostasis in ageing	377
Modulating cell-free DNA biology as the next frontier in liquid biopsies	354
Understanding human embryogenesis by building programmable stem cell-based models	277
KCTD10 resolves co-directional transcription–replication conflicts	267
The bidirectional relationship between metabolism and cell cycle control	234
HELLS: the transcriptional sentinel	205
Centrosomes and cancer: balancing tumor-promoting and inhibitory roles	190
Unlocking Latin America´s scientific potential: challenges and opportunities in a globalized world	186
Plasticity of cancer invasion and energy metabolism	181
(Alternative) transcription start sites as regulators of RNA processing	177
Lysosome: a critical hub for ferroptosis regulation	165
Whi3key old fashioned: a condensate cocktail for cell fate decisions	142
H3K9 trimethylation homeostasis: mechanisms, crosstalk, and cancer relevance	139
Optical tweezers across scales in cell biology	136
Cytoplasmic mtDNA clearance suppresses inflammatory immune responses	134
Membrane curvature at the ER–PM contact sites	132
Subscription and Copyright Information	132
Advisory Board and Contents	131
Subscription and Copyright Information	126
Regulation of lipid droplet dynamics and lipid homeostasis by hydroxysteroid dehydrogenase proteins	123
The multifaceted mitochondrial OXA insertase	123
Where protein structure and cell diversity meet	119
Olfaction: an emerging regulator of longevity and metabolism	108

What makes genes burst	105
Bucket lists must be completed during cell death	98
Opportunities and challenges for deep learning in cell dynamics research	97
POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer	96
Progress and limitations in engineering cellular adhesion for research and therapeutics	90
Deciphering the significance of p53 mutant proteins	88
Lessons in longevity from blood stem cells under protein stress	88
DDX47 untangles R-loops with only certain other helicases	86
tRNA modifications: insights into their role in human cancers	85
AMPK: a master regulator of mitochondrial quality and quantity	85
Sublethal engagement of apoptotic pathways in residual cancer	84
Bioelectric regulation of intestinal stem cells	83
Cultured meat: creative solutions for a cell biological problem	81
Optimality as a framework for understanding developmental robustness	80
The promiscuous ribosomal P-stalk: a new functional portrait	80
The emergence of the stem cell niche	79
Diverse routes to mitophagy governed by ubiquitylation and mitochondrial import	78
Multifaceted mitochondrial quality control in brown adipose tissue	77
Visualizing intracellular target antigens in live cells	77
Advisory Board and Contents	75
Reimagining journal clubs for inclusive scientific training	74
Built to last: lysosome remodeling and repair in health and disease	73
Moonlighting translation factors: multifunctionality drives diverse gene regulation	73
Reprogramming transcription after DNA damage: recognition, response, repair, and restart	72
Self-inflicted DNA breaks in cell differentiation and cancer	72
Endoplasmic reticulum (ER) protein degradation by ER-associated degradation and ER-phagy	70
Mitochondrial transfer at the crossroads of cancer, stromal, and immune cells	69
Tumor–stromal metabolic crosstalk in pancreatic cancer	68
Wnt signalling in cell division: from mechanisms to tissue engineering	66
Fun in the sun: ribosomes defend against UV irradiation	64
Accessible high-speed image-activated cell sorting	64
Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer	64
Young researchers series #3	62
Advisory Board and Contents	61
Young researchers series #3	61
Subscription and Copyright Information	60
Advisory Board and Contents	60
Advisory Board and Contents	60
Young researchers series #7	59
Thermoporter: a new regulatory mechanism for mitochondrial calcium uniporter activity	57
Meiotic spindle pushed outward by inward organelle packing	56
Advisory Board and Contents	54
Telomere dynamics as mediators of gut microbiota–host interactions	54
Subscription and Copyright Information	53
Embryos burn fat in standby	53
Revealing new biology from multiplexed, metal-isotope-tagged, single-cell readouts	51
Targeting SHP1 and SHP2 to suppress tumors and enhance immunosurveillance	50
Transcription-coupled repair of DNA–protein crosslinks	50
Membrane remodeling and trafficking piloted by SARS-CoV-2	50
Filopodia: integrating cellular functions with theoretical models	49

Unique architectural features of mammalian mitochondrial protein synthesis	48
ERMCS Ca2+ transmission fuels cell division	48
Advisory Board and Contents	46
Advisory Board and Contents	46
Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia	46
Increased O-GlcNAcylation connects metabolic to transcriptional reprogramming during pathophysiological cell activation	45
Orientational cell adhesions (OCAs) for tissue morphogenesis	45
Subscription and Copyright Information	45
Chaperone networks are shaped by cellular differentiation and identity	44
The idiosyncrasies of oocytes	43
Order from chaos: cellular asymmetries explained with modelling	43
Cell cycle regulation by the ribotoxic stress response	43
Expanding roles of N-glycosylation in the endoplasmic reticulum	43
Disruption of lineage integrity as a precursor to breast tumor initiation	42
Oxidative DNA damage and repair at non-coding regulatory regions	42
Young researchers series #6	42
ER: a critical hub for STING signaling regulation	42
Phase separation on microtubules: from droplet formation to cellular function?	42
Cellular mechanics during division of a genomically minimal cell	41
Versatility of gasdermin D beyond pyroptosis	41
Patterns in the tapestry of chromatin-bound RB	41
Sugar symphony: glycosylation in cancer metabolism and stemness	41
Bloodhounds chasing the origin of blood cells	41
Lysosomal enzyme trafficking: from molecular mechanisms to human diseases	40
Regulation of gene expression by glycolytic and gluconeogenic enzymes	39
Mechanical regulation of cell-cycle progression and division	39
Subscription and Copyright Information	38
Subscription and Copyright Information	37
Subscription and Copyright Information	37
Advisory Board and Contents	37
Advisory Board and Contents	37
Subscription and Copyright Information	37
The adipocyte supersystem of insulin and cAMP signaling	36
Creating inclusive environments in cell biology by casual mentoring	36
Death by ribosome	34
New job for an old tool: PI3Kβ phosphorylates OGT to regulate acetyl-CoA in glioblastoma	34
Spermidine – an old molecule with a new age-defying immune function	34
The neuronal-like behaviour of macrophages	34
The peroxisome: an up-and-coming organelle in immunometabolism	34
Extracellular vesicle-mediated crosstalk in tumor microenvironment dominates tumor fate	34
Immune surveillance of senescence: potential application to age-related diseases	33
The many faces of H3.3 in regulating chromatin in embryonic stem cells and beyond	33
Changing the culture for the future: time to take brain drain in academics seriously	33
The ubiquitin–proteasome system links NADPH metabolism to ferroptosis	31
The epigenetic landscape of mesenchymal stem cell and extracellular vesicle therapy	31
The Cys/N-degron pathway in the ubiquitin–proteasome system and autophagy	31
Quality control of mitochondrial nucleoids	31
Targeting mitochondrial dynamics against cancer	30
Muscle is a stage, and cells and factors are merely players	30
CS proteins and ubiquitination: orchestrating DNA repair with transcription and cell division	30
Calcium homeostasis and cancer: insights from endoplasmic reticulum-centered organelle communications	29
Chromatin-interacting RNA-binding proteins regulate transcription	29
ER remodeling via lipid metabolism	29
Subscription and Copyright Information	29
Stress-induced cell depolarization through the MAP kinase–Cdc42 axis	29
Phase separation of p62: roles and regulations in autophagy	29
Metabolic regulation of mRNA splicing	28
Advisory Board and Contents	28
Advisory Board and Contents	28
Subscription and Copyright Information	28
Advisory Board and Contents	28
3′UTR heterogeneity and cancer progression	27
Tumor-initiating cells establish a niche to overcome isolation stress	27
Regulated circRNA nuclear export in neuronal differentiation	27
Molecular mechanisms of nucleolar DNA damage checkpoint response	27
Glucose metabolism of TAMs in tumor chemoresistance and metastasis	26
The Warburg effect: a signature of mitochondrial overload	26
The heterogeneity of cellular senescence: insights at the single-cell level	26
Subscription and Copyright Information	25
Regulation of leukemogenesis via redox metabolism	25
Emerging roles of intratumor microbiota in cancer metastasis	25
ATRX loss induces lineage plasticity and squamous-like phenotype to promote colorectal cancer metastasis	25
Hard to handle: how lipid saturation affects the nuclear envelope	24
Decoding human cardiovascular development and disease through single-cell transcriptomic and epigenomic profiling	24
Advisory Board and Contents	24
Time matters: the dynamics of plasma membrane repair	24
Subscription and Copyright Information	24
Fracture in living tissues	24
Multifaceted collagen-DDR1 signaling in cancer	23
The autophagy–NAD axis in longevity and disease	23

DNA single-strand break repair and human genetic disease	23
RNA G-quadruplexes and stress: emerging mechanisms and functions	23
Technological and computational advances driving high-throughput oncology	22
TFEB links the cGAS-STING pathway to lysosome biogenesis	22
Fumarate hydratase as a metabolic regulator of immunity	22
Extracellular vesicles from the dead: the final message	22
Celebrating 35 years of Trends in Cell Biology and introducing our special issue on ribosomal dynamics and cellular homeostasis	21
Subscription and Copyright Information	21
Subscription and Copyright Information	21
Ferroptosis as an approach to leverage cancer metabolism	21
Novel imaging methods and force probes for molecular mechanobiology of cytoskeleton and adhesion	21
Clonal hematopoiesis and inflammation – the perpetual cycle	20
Mechanism-aware and multimodal AI: beyond model-agnostic interpretation	20
How pervasive are post-translational and -transcriptional modifications?	20
Glucagon-producing α-cell transcriptional identity and reprogramming towards insulin production	20
Neutral lipid quality control gates ferroptotic cell death	19
The role of the immune tumor microenvironment in shaping metastatic dissemination, dormancy, and outgrowth	19
Hypoxia-specific transcriptional condensates drive metastasis	19
Ferroptosis: mechanisms and implications for cancer development and therapy response	19
Advisory Board and Contents	19
Advancing cell biology with nanoscale fluorescence imaging: essential practical considerations	19
Mitochondrial substrate oxidation regulates distinct cell differentiation outcomes	19
Degradation of nuclear components via different autophagy pathways	18
Reflected stemness as a potential driver of the tumour microenvironment	18
The role of RAS oncogenes in controlling epithelial mechanics	18
The initiation of mammalian embryonic transcription: to begin at the beginning	18
The enigmatic roles of epithelial gasdermin B: Recent discoveries and controversies	18
Multiplicity of stem cell memories of inflammation and tissue repair in epithelia	18
Implementing standardized diversity, equity, and inclusion approaches within scientific communities	18
Mechanisms of cellular mRNA transcript homeostasis	17
A novel superfamily of bridge-like lipid transfer proteins	17
Spotlighting adult stem cells: advances, pitfalls, and challenges	17
Extracellular matrix remodeling facilitates obesity-associated cancer progression	17
Where you start could determine where you end up	17
Time as a danger signal promoting G1 arrest after mitosis	17
CDK11, a splicing-associated kinase regulating gene expression	16
Subscription and Copyright Information	16
Inter-membrane control of junctional InsP3 receptors by PIP2	16
MDM4 exon skipping upon dysfunctional ribosome assembly	16
Organelle-specific signaling of cGAS–STING	16
Newly identified cell types crucial for gut commensal tolerance	16
Mechanobiology of organelles: illuminating their roles in mechanosensing and mechanotransduction	15
Experimental evolution for cell biology	15
The culture and application of circulating tumor cell-derived organoids	15
Cullin–RING receptors in rare disease biology	15
Cellular plasticity in reprogramming, rejuvenation and tumorigenesis: a pioneer TF perspective	15
3D genome folding in epigenetic regulation and cellular memory	15
miRNA dosage control in development and human disease	15
Roles of YAP/TAZ in ferroptosis	14
NADH reductive stress drives metabolic reprogramming	14
Coordinated in confined migration: crosstalk between the nucleus and ion channel-mediated mechanosensation	14
PYK2, a hub of signaling networks in breast cancer progression	14
Vimentin at the core of wound healing	14
Cholesterol metabolism regulates macrophage function and inflammation-related diseases	14
Advisory Board and Contents	13
Lysosomal microautophagy: an emerging dimension in mammalian autophagy	13
Is clathrin a membrane fission protein?	13
Triple threat: neutrophil ER stress, NETosis, airway inflammation escalation	13
Tau liquid–liquid phase separation in neurodegenerative diseases	13
Plasma membrane damage is a new trigger of cellular senescence	13
Advisory Board and Contents	13
The cell biology of APOE in the brain	13
Experimental tools and emerging principles of organellar mechanotransduction	12
Central role of the ER proteostasis network in healthy aging	12
Emerging roles of olfactory receptors in glucose metabolism	12
The ins-and-outs of exosome biogenesis, secretion, and internalization	12
Regulatory landscape of enhancer-mediated transcriptional activation	12
Nuclear speckles: a fundamental layer of gene regulation	12
Arming a killer: mitochondrial regulation of CD8+ T cell cytotoxicity	12
Metabolism and mRNA translation: a nexus of cancer plasticity	11
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Phenotypic plasticity during metastatic colonization	11
How it feels in a cell	11
Subscription and Copyright Information	11
Role of lipids in interorganelle communication	11
Advisory Board and Contents	11
Transsulfuration, minor player or crucial for cysteine homeostasis in cancer	10
Towards solving the mystery of peroxisomal matrix protein import	10
Is euchromatin really open in the cell?	10
Nutrient availability as an arbiter of cell size	10
The multifaceted role of kidney tubule mitochondrial dysfunction in kidney disease development	10
Metabolism and HSC fate: what NADPH is made for	10
Navigating AKT-ivity across cellular compartments	10
Integrating mechanical signals into cellular identity	10
Autophagosomal components recycling on autolysosomes	10
Gasdermins gone wild: new roles for GSDMs in regulating cellular homeostasis	10
Advisory Board and Contents	10
Sodium channels in non-excitable cells: powerful actions and therapeutic targets beyond Hodgkin and Huxley	9
Homeostasis of megakaryocytes: balancing tissue residency and consumptive platelet production	9
The yin and yang of nuclear envelope breakdown through the activity of phosphatase holoenzyme PP2A-B55SUR-6	9
Lysosomal control of the cGAS-STING signaling	9
Advisory Board and Contents	9
Advisory Board and Contents	9
Generating exosome subtypes: diverse membrane origins and mergers	9
Advisory Board and Contents	9