Trends in Biochemical Sciences

Article	Citations
Subscription and Copyright Information	321
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Adding post-translational modifications and protein–protein interactions to protein schematics	150
Advisory Board and Contents	147
Multiplayer virtual reality for understanding biomolecular structures	146
Understanding peptide hormones: from precursor proteins to bioactive molecules	145
Harnessing the power of peptides: advances and collaborations in biochemistry	121
Advisory Board and Contents	110
Transporter Specificity: A Tale of Loosened Elevator-Sliding	101
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	98
Conserved signaling gears that sustain circadian clock robustness	96
Novel machine learning approaches revolutionize protein knowledge	95
Decoding ceramide function: how localization shapes cellular fate and how to study it	91
Did circular DNA shape the evolution of mammalian genomes?	89
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	88
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	87
Cellular oxidants and the proteostasis network: balance between activation and destruction	85
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	78
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	78
From lead to market: chemical approaches to transform peptides into therapeutics	77
Molecular mechanisms of heat shock factor 1 regulation	75
Exploiting enzyme evolution for computational protein design	70
Transcription-coupled global genomic repair in E. coli	70
Determining and interpreting protein lifetimes in mammalian tissues	69

Structural parasitology of the malaria parasite Plasmodium falciparum	69
Using graphs and charts in scientific figures	69
Subconductance states add complexity to Piezo1 gating model	67
The transition phase: preparing to launch a laboratory	66
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	66
Transcription-coupled nucleosome assembly	60
Exploring membrane asymmetry and its effects on membrane proteins	59
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	58
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	58
Proteasome-derived peptides: separating the trash from the recycling	57
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	56
Creative approaches using proximity labeling to gain new biological insights	56
Activation, decommissioning, and dememorization: enhancers in a life cycle	54
Glucokinase: from allosteric glucose sensing to disease variants	53
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	52
Microtubule nucleation for spindle assembly: one molecule at a time	51
Cell entry by SARS-CoV-2	51
Diverse heterochromatin states restricting cell identity and reprogramming	50
Apart, together	49
Advisory Board and Contents	49
Engineering RiPP pathways: strategies for generating complex bioactive peptides	47
The metabolic code of ferroptosis: nutritional regulators of cell death	46
Subscription and Copyright Information	46
Making nucleic acid structures and schematics	45
Two hearts beat as one: the debate over RAS dimers continues	44
A plant immune protein fights against cancer	43
An outreach activity to enhance biochemistry pedagogy	43
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	43
Thiol dioxygenases: from structures to functions	42
Control of chloroplast degradation and cell death in response to stress	42
The expanding landscape of canonical and non-canonical protein phosphorylation	40
Innovations in the electron transport chain fuel archaeal methane metabolism	39
Making ends meet: a universal driver of large ribosomal subunit biogenesis	39
Mitochondrial compartmentalization: emerging themes in structure and function	38
Seeing the forest through the trees: characterizing the glycoproteome	38
The RNA tether model for human chromosomal translocation fragile zones	38
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	38
Functional modulation of chemical mediators in microbial communities	37
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	37
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Cloud computing platforms to support cryo-EM structure determination	34
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	33
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	33
Convergent evolution in two bacterial replicative helicase loaders	33
Liquid–liquid phase separation in presynaptic nerve terminals	32
Non-histone binding functions of PHD fingers	32
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	31
Origins and evolving functionalities of tRNA-derived small RNAs	30
Metamorphic protein folding as evolutionary adaptation	29

Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	29
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
Time-resolved serial crystallography to reveal protein structural changes	28
CryoEM shows the active dynein complex on microtubules	28
Cooperative assembly of the mitochondrial respiratory chain	28
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Advisory Board and Contents	28
Recent advances in enzymes active on lignin-derived aromatic compounds	27
The crosstalk of m6A-modified RNA with DNA damage repair	27
Advisory Board and Contents	27
Does chromatin function as a metabolite reservoir?	27
Multifaceted control of T cell differentiation by STIM1	27
Programmable protein editing	26
Forging a path toward a more sustainable laboratory	26
Proteostasis in cellular dormancy: lessons from yeast to oocytes	26
Lamin post-translational modifications: emerging toggles of nuclear organization and function	26
Circular RNAs in physiology and non-immunological diseases	25
Orange carotenoid proteins: structural understanding of evolution and function	25
Advances, challenges, and opportunities in structural biology	25
Lysines and cysteines: partners in stress?	25
Monitoring subcellular NADP redox state with NAPstar biosensors	25
Advancing nanopore technology toward protein identification and sequencing	25
Computationally guided AAV engineering for enhanced gene delivery	24
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Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	24
TRAPs: the ‘elevator-with-an-operator’ mechanism	24
Lipidation status of single membrane-associated ATG8 proteins	23
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	23
Wrapping up a special series on scientific figure development	23
Protein SUMOylation and phase separation: partners in stress?	23
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FN3K: the (un)sweetest kinase	22
To Ub or not to Ub: a regulatory question in TGF-β signaling	22
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	22
Endogenous plant nitroxyl, a new component of nitric oxide biology	22
How to compile different types of structural visualizations in one panel	22
How integrin phosphorylations regulate cell adhesion and signaling	21
Oxytocin and vasopressin signaling in health and disease	21
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	21
Discordant skeletal muscle gene and protein responses to exercise	21
Advisory Board and Contents	20
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	20
Synaptoneurolipidomics: lipidomics in the study of synaptic function	20
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SRC homology 3 domains: multifaceted binding modules	20
Protein Termini 2022: central roles of protein ends	20
Discovering riboswitches: the past and the future	20
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	19
Structural transitions modulate the chaperone activities of Grp94	18
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	18
Creating accessibility in academic negotiations	18
Spray-type modifications: an emerging paradigm in post-translational modifications	18
Mitochondrial DNA: cellular genotoxic stress sentinel	18
Enlightening epigenetics: optochemical tools illuminate the path	18
Maximizing grant funding: strategies for negotiating laboratory pricing	18
Biomolecules capturing live bacteria from clinical samples	18
Advisory Board and Contents	17
Uncovering viral RNA–host cell interactions on a proteome-wide scale	17
Take Your PIC	17
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Understanding the dynamic design of the spliceosome	17
More Than Just Closed and Open: Unraveling a Mechanosensor	17
Regulation of Autophagy Enzymes by Nutrient Signaling	17
Cytoplasmic gene expression: lessons from poxviruses	17
Using light to drive energy transduction in metazoan aging	16
Transforming eukaryotic cell culture with macromolecular crowding	16
Structural advances in sterol-sensing domain-containing proteins	16
A vigilant gliding bird protects plants	16
Film-like organelles equip cells with multiple genetic codes	16
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Advisory Board and Contents	16
Advisory Board and Contents	16
Thermal proteome profiling of protein-centric interactions and modifications	16
The lysosome as a master regulator of iron metabolism	15
Substrate and phosphorylation site selection by phosphoprotein phosphatases	15
Mitochondria in disease: changes in shapes and dynamics	15
Coupling lipid synthesis with nuclear envelope remodeling	15
News about amino acid metabolism in plant–microbe interactions	15
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Advisory Board and Contents	14

Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design	13
Consequences of telomere replication failure: the other end-replication problem	13
Advisory Board and Contents	13
Microtubule specialization by +TIP networks: from mechanisms to functional implications	13
Histone-mediated chromatin organization in prokaryotes and viruses	13
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How do plants feel the heat and survive?	13
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Translational control through ribosome heterogeneity and functional specialization	13
Regulation of Dishevelled protein activity and stability by post-translational modifications and autophagy	13
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Unlocking translational machinery for antitubercular drug development	12
The quest to identify ADP-ribosylation readers: methodological advances	12
Confluence and convergence of Dscam and Pcdh cell-recognition codes	12
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?	12
The metabolic cross-talk between cancer and T cells	12
Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells	12
Mitochondrial heat production: the elephant in the lab…	12
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Giant variations in giant virus genome packaging	12
The enzymes for genome size increase and maintenance of large (+)RNA viruses	12
The physiological relevance of autophagosome morphogenesis	12
LncRNAs: the missing link to senescence nuclear architecture	11
Mechanisms of Gβγ Release upon GPCR Activation	11
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions	11
Mechanisms and rationales of SAM homeostasis	11
ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising	11
Looking lively: emerging principles of pseudokinase signaling	11
Advisory Board and Contents	11
Important questions and future directions in plant biochemistry	10
Two for one: regulatory RNAs that encode small proteins	10
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain	10
The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases	10
Insights into mitoribosomal biogenesis from recent structural studies	10
Assembling the jigsaw puzzle of life	10
Biogenesis and engineering of interleukin 12 family cytokines	10
Building a laboratory and networks during the COVID-19 pandemic	10
RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer	10
Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology	10
Back on the chain gang: polyphosphate modification of proteins	10
Biosensor for monitoring PTEN activity in biological systems	10
Ensembles of synthetic polymers mimic biological fluids	10
Textbook oxidative phosphorylation needs to be rewritten	10
Coenzyme Q biochemistry and biosynthesis	10
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Mps1 kinase functions in mitotic spindle assembly and error correction	9
cAMP signaling: a remarkably regional affair	9
Chemical probes for imaging cellular compartmentalization	9
Chemical genetic methodologies for identifying protein substrates of PARPs	9
Size does matter: piRNA and miRNA targeting	9
Molecular determinants of protein evolvability	9
Creating overview and summary figures	9
Mapping histone modification-dependent protein interactions with chemical proteomics	9
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Understanding mitochondrial protein import: a revised model of the presequence translocase	8
Diverse lineages and adaptations of oxygen-adapted hydrogenases	8
Assembly and function of branched ubiquitin chains	8
Advisory Board and Contents	8
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	8
Trials and tribulations of statistical significance in biochemistry and omics	8
Advisory Board and Contents	8
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	8
Frozen motion: how cryo-EM changes the way we look at ABC transporters	8
Z-DNA at the crossroads: untangling its role in genome dynamics	8
Contributions of single-particle cryoelectron microscopy toward fighting COVID-19	8
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Machine learning and protein allostery	7
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time	7
Advisory Board and Contents	7
Characterizing Circular RNAs Using Nanopore Sequencing	7
Interplay of cGAS with chromatin	7
Joan J. Guinovart (1947–2025)	7
PML isoforms: a molecular basis for PML pleiotropic functions	7
Endomembrane GPCR signaling: 15 years on, the quest continues	7
Mammalian viral suppressors of RNA interference	7
Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins	7
Advisory Board and Contents	7
Structural basis of torque generation in the bi-directional bacterial flagellar motor	6
Broadening access to cryoEM through centralized facilities	6
Cell surface RNA biology: new roles for RNA binding proteins	6
IUBMB Trainee Initiative: supporting emerging biochemists and molecular biologists around the world	6
Detecting and Rescuing Stalled Ribosomes	6
The emerging roles of S-acylation in autophagy	6
Methods for the directed evolution of biomolecular interactions	6
Beyond Autophagy: The Expanding Roles of ATG8 Proteins	6
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mRNA accessibility within mRNPs as a determinant of gene expression	6
BRCA1/BARD1 is a nucleosome reader and writer	6
Incorporating chemical structures into scientific figures	5
A chemical biology/modular antibody platform for ADP-ribosylation signaling	5
Advisory Board and Contents	5
Protein–membrane interactions: sensing and generating curvature	5
ProP-PD for proteome-wide motif-mediated interaction discovery	5