Trends in Biochemical Sciences

Article	Citations
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Capturing 3D macromolecule structure in 2D images	238
Lipidation status of single membrane-associated ATG8 proteins	214
Hypoxia research, where to now?	150
Synaptoneurolipidomics: lipidomics in the study of synaptic function	147
Decoding ceramide function: how localization shapes cellular fate and how to study it	143
A wrinkle in timers: evolutionary rewiring of conserved biological timekeepers	136
From lead to market: chemical approaches to transform peptides into therapeutics	131
Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications	131
SRC homology 3 domains: multifaceted binding modules	125
Transporter Specificity: A Tale of Loosened Elevator-Sliding	119
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CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	105
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	94
Oxytocin and vasopressin signaling in health and disease	89
A special series on scientific figure development	88
Subscription and Copyright Information	85
Recruiting women faculty through inclusive, family-friendly practices	84
How to compile different types of structural visualizations in one panel	83
Chemical probes for imaging cellular compartmentalization	81
New paradigm for teaching scientific writing in STEM	80
Turning science into cover art	79
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One Ring to Rule them All? Structural and Functional Diversity in the Nuclear Pore Complex	77
A NuRD for all seasons	77

Z-DNA at the crossroads: untangling its role in genome dynamics	72
Creating overview and summary figures	72
Advisory Board and Contents	71
Depicting protein structures as schematics	71
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	67
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Adding post-translational modifications and protein–protein interactions to protein schematics	63
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To Ub or not to Ub: a regulatory question in TGF-β signaling	63
Wrapping up a special series on scientific figure development	62
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RNA levers and switches controlling viral gene expression	62
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Physiological media advance cell culture experiments	57
Mps1 kinase functions in mitotic spindle assembly and error correction	57
Immunometabolism in atherosclerosis: a new understanding of an old disease	54
Exploring cross-α amyloids: from functional roles to design innovations	53
Discordant skeletal muscle gene and protein responses to exercise	53
Migrasome biogenesis: when biochemistry meets biophysics on membranes	52
Trials and tribulations of statistical significance in biochemistry and omics	51
Size does matter: piRNA and miRNA targeting	49
The Spatial Organization of Sister Chromatids	48
Microbial Prions: Dawn of a New Era	48
On the Cutting Edge: Regulation and Therapeutic Potential of the mRNA 3′ End Nuclease	46
Closing the structure-to-function gap for LRRK2	45
Seeing Atoms by Single-Particle Cryo-EM	45
Chemical genetic methodologies for identifying protein substrates of PARPs	44
A ‘NAC’ for targeting proteins to the ER	43
Contributions of single-particle cryoelectron microscopy toward fighting COVID-19	43
Kinetics of RNA–protein interactions in cells	42
Mapping histone modification-dependent protein interactions with chemical proteomics	42
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	41
Targeting protein conformations with small molecules to control protein complexes	41
A kinetic mechanism for systems-level behavior in GTPase signaling	41
Substrate recognition and transport mechanism of the PIN-FORMED auxin exporters	41
A left-handed RNA quadruplex directs gene silencing	40
Multiplayer virtual reality for understanding biomolecular structures	40
Revealing eEF-2 kinase: recent structural insights into function	39
Protein SUMOylation and phase separation: partners in stress?	39
Diseases caused by altered specificity of a protein kinase for its allosteric activators	39
Ubiquitin system mutations in neurological diseases	39
The role of hydrolysis in perceiving and degrading the plant hormone strigolactones	38
AI interprets the Central Dogma and Genetic Code	38
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	36
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	36
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	36
Assembly and function of branched ubiquitin chains	35
Novel machine learning approaches revolutionize protein knowledge	35
Through the looking glass: milestones on the road towards mirroring life	34

Structural Basis for the Modulation of Ryanodine Receptors	34
Did circular DNA shape the evolution of mammalian genomes?	34
DNA segregation in mitochondria and beyond: insights from the trypanosomal tripartite attachment complex	34
Cryo-electron tomography of enveloped viruses	33
Canary in a coal mine: collided ribosomes as sensors of cellular conditions	33
Proteasome substrate receptors and their therapeutic potential	32
How integrin phosphorylations regulate cell adhesion and signaling	32
Cellular oxidants and the proteostasis network: balance between activation and destruction	31
Frozen motion: how cryo-EM changes the way we look at ABC transporters	30
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	30
Protein kinase C: release from quarantine by mTORC2	30
NAD-capped RNAs – a redox cofactor meets RNA	30
Endogenous plant nitroxyl, a new component of nitric oxide biology	30
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	26
Understanding mitochondrial protein import: a revised model of the presequence translocase	26
Coordinating gene expression during the cell cycle	26
Molecular mechanisms of heat shock factor 1 regulation	26
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	25
The NLRP3 inflammasome: activation and regulation	25
Discovering riboswitches: the past and the future	25
Exploiting enzyme evolution for computational protein design	24
Plant-based carboxysomes: another step toward increased crop yields	23
Biomolecules capturing live bacteria from clinical samples	23
Discovery, biochemical characterization, and bioengineering of cyanobactin prenyltransferases	23
Advisory Board and Contents	22
Advisory Board and Contents	22
Seeing smell: the structural underpinnings of insect olfaction	22
Advisory Board and Contents	22
In vivo single-molecule RNA structural profiling	22
Advisory Board and Contents	21
(G)Patching up mis-splicing in cancer	21
Advisory Board and Contents	21
Pushing boundaries of cryo-EM	20
Advisory Board and Contents	20
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Protein Termini 2022: central roles of protein ends	19
Advisory Board and Contents	19
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The transition phase: preparing to launch a laboratory	19
Pre-twisting for improved genome modification and miRNA targeting	19
Maximizing grant funding: strategies for negotiating laboratory pricing	19
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	19
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Advisory Board and Contents	19
Presenting technological workflows	19
The Hammer and the Dance of Cell Cycle Control	18
cCMP and cUMP come into the spotlight, finally	18
Limitations in membrane protein structure determination by lipid nanodiscs	18
Advisory Board and Contents	18
A new path for terpenoid biosynthesis	18
A physicochemical perspective on cellular ageing	18
Interplay of cGAS with chromatin	17
Crosslinking and Mass Spectrometry to Identify Regulators in Unconventional Secretion	17
PML isoforms: a molecular basis for PML pleiotropic functions	17
Membrane protein synthesis: no cells required	17
Completing the canvas: advances and challenges for DNA-PAINT super-resolution imaging	17
Chemoproteomic approach for mapping binding sites of post-translational-modification-mediated protein–protein interactions	17
Characterizing Circular RNAs Using Nanopore Sequencing	17
The Life Cycle of the Mu-Opioid Receptor	17
Spray-type modifications: an emerging paradigm in post-translational modifications	16
Feeling the heat: how chaperones deal with biomolecular condensates	16
Transcription-coupled global genomic repair in E. coli	16
Mammalian viral suppressors of RNA interference	16
Creating accessibility in academic negotiations	16
Microtubule nucleation for spindle assembly: one molecule at a time	16
High-throughput approaches to understand and engineer bacteriophages	16
Protein lipoylation: mitochondria, cuproptosis, and beyond	15
Defining the commonalities between post-transcriptional and post-translational modification communities	15
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	15
ULK/Atg1: phasing in and out of autophagy	15
Helicases clear hurdles during plant defense protein translation	15
The Leishmania ribosome: more than passive mRNA translating machinery	15
Endomembrane GPCR signaling: 15 years on, the quest continues	14
Diverse heterochromatin states restricting cell identity and reprogramming	14
Functionalized DNA secondary structures and nanostructures for specific protein modifications	14
Assembling a Hippo: the evolutionary emergence of an animal developmental signaling pathway	14
Enlightening epigenetics: optochemical tools illuminate the path	13

Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins	13
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	13
Subconductance states add complexity to Piezo1 gating model	13
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	13
FUS and TDP-43 Phases in Health and Disease	13
Mentoring during Uncertain Times	13
Uncovering viral RNA–host cell interactions on a proteome-wide scale	13
Roles and dynamics of 3-methylcytidine in cellular RNAs	13
TCA cycle off, ATF4 on for metabolic homeostasis	13
Understanding the dynamic design of the spliceosome	12
Structural parasitology of the malaria parasite Plasmodium falciparum	12
Creative approaches using proximity labeling to gain new biological insights	12
Structural transitions modulate the chaperone activities of Grp94	12
Glucokinase: from allosteric glucose sensing to disease variants	11
Cytoplasmic gene expression: lessons from poxviruses	11
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	11
PARPs and ADP-ribosylation-mediated biomolecular condensates: determinants, dynamics, and disease implications	11
The emerging roles of S-acylation in autophagy	11
The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis	11
Determining and interpreting protein lifetimes in mammalian tissues	11
The spindle checkpoint proteins BUB1 and BUBR1: (SLiM)ming down to the basics	11
Transcription-coupled nucleosome assembly	10
Detecting and Rescuing Stalled Ribosomes	10
Plant biochemistry influences tropospheric ozone formation, destruction, deposition, and response	10
The inner workings of an ancient biological clock	10
AID/APOBEC: an expanding repertoire of targets and functions	10
Structural basis of torque generation in the bi-directional bacterial flagellar motor	10
Recent advances in predicting and modeling protein–protein interactions	10
Machine learning and protein allostery	10
UFMylation: a ubiquitin-like modification	10
Exploring membrane asymmetry and its effects on membrane proteins	10
Ribosomal DNA and the nucleolus at the heart of aging	9
Cell entry by SARS-CoV-2	9
Mitochondrial DNA: cellular genotoxic stress sentinel	9
Advisory Board and Contents	9
Beyond Autophagy: The Expanding Roles of ATG8 Proteins	9
Activation, decommissioning, and dememorization: enhancers in a life cycle	9
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	9
Advisory Board and Contents	9
Using graphs and charts in scientific figures	9
Regulation of Autophagy Enzymes by Nutrient Signaling	9
Advisory Board and Contents	9
The twisted path of the 3D genome: where does it lead?	8
Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels	8
Advisory Board and Contents	8
Advisory Board and Contents	8
Making nucleic acid structures and schematics	8
Broadening access to cryoEM through centralized facilities	8
Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy	8
Advisory Board and Contents	8
Advisory Board and Contents	8
Molecular Determinants of Flavivirus Virion Assembly	8
Histone Tail Conformations: A Fuzzy Affair with DNA	8
Using light to drive energy transduction in metazoan aging	8
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Advisory Board and Contents	7
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	7
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Advisory Board and Contents	7
Ultrahigh-throughput screening in microfluidic droplets: a faster route to new enzymes	7
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Advisory Board and Contents	7
Dynamics and logic of promoter melting	7
You come at the misfolded proteins, you best not miss	7
Advisory Board and Contents	7
Advances and challenges in identifying and characterizing G-quadruplex–protein interactions	6
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Advisory Board and Contents	6
Advisory Board and Contents	6
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IUBMB Trainee Initiative: supporting emerging biochemists and molecular biologists around the world	6
Snapshots of a tiny ancestral nuclease of Cas9	6
Apart, together	6
Transforming eukaryotic cell culture with macromolecular crowding	6
Take Your PIC	6
The Evolution of STING Signaling and Its Involvement in Cancer	5
Tinker, tailor, antiviral: RNA virus inhibition by induced recombination	5
Coupling lipid synthesis with nuclear envelope remodeling	5
Methods for the directed evolution of biomolecular interactions	5
Film-like organelles equip cells with multiple genetic codes	5
Deconstructing the transmembrane core of class A G protein–coupled receptors	5
Hydroxyl radical protein footprinting for analysis of higher order structure	5
Mitochondrial compartmentalization: emerging themes in structure and function	5
More Than Just Closed and Open: Unraveling a Mechanosensor	5
Let’s phase it: viruses are master architects of biomolecular condensates	5
Seeing the forest through the trees: characterizing the glycoproteome	5
The expanding landscape of canonical and non-canonical protein phosphorylation	4
Thiol dioxygenases: from structures to functions	4
Type III CRISPR-Cas: beyond the Cas10 effector complex	4
Guidelines for organizing accessible and inclusive research retreats	4
A plant immune protein fights against cancer	4
Eph receptor signaling complexes in the plasma membrane	4
The RNA tether model for human chromosomal translocation fragile zones	4