OOIR: Observatory of International Research

Papers

(The median citation count of Trends in Biochemical Sciences is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Advisory Board and Contents	410
Adding post-translational modifications and protein–protein interactions to protein schematics	218
Subscription and Copyright Information	195
Multiplayer virtual reality for understanding biomolecular structures	118
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	114
Subscription and Copyright Information	111
Subscription and Copyright Information	109
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	104
Conserved signaling gears that sustain circadian clock robustness	104
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	104
Novel machine learning approaches revolutionize protein knowledge	97
Advisory Board and Contents	95
Harnessing the power of peptides: advances and collaborations in biochemistry	92
Decoding ceramide function: how localization shapes cellular fate and how to study it	87
Understanding peptide hormones: from precursor proteins to bioactive molecules	87
Cellular oxidants and the proteostasis network: balance between activation and destruction	82
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	77
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	76
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	74
From lead to market: chemical approaches to transform peptides into therapeutics	73
Did circular DNA shape the evolution of mammalian genomes?	72
Exploiting enzyme evolution for computational protein design	68
Molecular mechanisms of heat shock factor 1 regulation	68
Transcription-coupled nucleosome assembly	67
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	66

Proteasome-derived peptides: separating the trash from the recycling	64
Transcription-coupled global genomic repair in E. coli	63
The transition phase: preparing to launch a laboratory	61
Using graphs and charts in scientific figures	58
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	57
Diverse heterochromatin states restricting cell identity and reprogramming	56
Subconductance states add complexity to Piezo1 gating model	55
Autophagy regulation by phase separation, avidity, and wetting	54
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	54
Microtubule nucleation for spindle assembly: one molecule at a time	53
Structural parasitology of the malaria parasite Plasmodium falciparum	51
Mitochondrial dynamics and pore formation in regulated cell death pathways	50
Glucokinase: from allosteric glucose sensing to disease variants	49
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	47
Exploring membrane asymmetry and its effects on membrane proteins	47
Determining and interpreting protein lifetimes in mammalian tissues	45
Two hearts beat as one: the debate over RAS dimers continues	44
Creative approaches using proximity labeling to gain new biological insights	44
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	44
Subscription and Copyright Information	44
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	44
Seeing the forest through the trees: characterizing the glycoproteome	44
Activation, decommissioning, and dememorization: enhancers in a life cycle	44
Thiol dioxygenases: from structures to functions	43
An outreach activity to enhance biochemistry pedagogy	43
A plant immune protein fights against cancer	42
Making nucleic acid structures and schematics	41
The RNA tether model for human chromosomal translocation fragile zones	40
Making ends meet: a universal driver of large ribosomal subunit biogenesis	40
Advisory Board and Contents	40
Functional modulation of chemical mediators in microbial communities	39
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	39
Innovations in the electron transport chain fuel archaeal methane metabolism	39
Engineering RiPP pathways: strategies for generating complex bioactive peptides	38
Control of chloroplast degradation and cell death in response to stress	37
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	36
The expanding landscape of canonical and non-canonical protein phosphorylation	36
Just bypass it: mechanisms of DNA damage tolerance	34
The metabolic code of ferroptosis: nutritional regulators of cell death	34
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	33
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	33
Subscription and Copyright Information	32
Cloud computing platforms to support cryo-EM structure determination	32
Convergent evolution in two bacterial replicative helicase loaders	32
Subscription and Copyright Information	31
Non-histone binding functions of PHD fingers	30
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	30
Liquid–liquid phase separation in presynaptic nerve terminals	30
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	30
Metamorphic protein folding as evolutionary adaptation	30

Zn2+ transients and signaling in mammalian systems	30
Advisory Board and Contents	29
Advisory Board and Contents	29
CryoEM shows the active dynein complex on microtubules	29
Recent advances in enzymes active on lignin-derived aromatic compounds	28
Forging a path toward a more sustainable laboratory	28
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
Orange carotenoid proteins: structural understanding of evolution and function	28
Programmable protein editing	28
Time-resolved serial crystallography to reveal protein structural changes	28
Proteostasis in cellular dormancy: lessons from yeast to oocytes	27
The crosstalk of m6A-modified RNA with DNA damage repair	27
Cooperative assembly of the mitochondrial respiratory chain	27
Circular RNAs in physiology and non-immunological diseases	27
Multifaceted control of T cell differentiation by STIM1	26
Subscription and Copyright Information	26
Does chromatin function as a metabolite reservoir?	26
Advancing nanopore technology toward protein identification and sequencing	25
Monitoring subcellular NADP redox state with NAPstar biosensors	25
Advisory Board and Contents	25
Advances, challenges, and opportunities in structural biology	25
Lysines and cysteines: partners in stress?	25
Computationally guided AAV engineering for enhanced gene delivery	25
TRAPs: the ‘elevator-with-an-operator’ mechanism	25
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	24
E3 ubiquitin ligases in signaling, disease, and therapeutics	24
FN3K: the (un)sweetest kinase	24
SRC homology 3 domains: multifaceted binding modules	24
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	24
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	23
Subscription and Copyright Information	22
How to compile different types of structural visualizations in one panel	22
Endogenous plant nitroxyl, a new component of nitric oxide biology	22
Wrapping up a special series on scientific figure development	22
Protein SUMOylation and phase separation: partners in stress?	21
Discordant skeletal muscle gene and protein responses to exercise	21
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	21
Discovering riboswitches: the past and the future	20
Synaptoneurolipidomics: lipidomics in the study of synaptic function	20
Oxytocin and vasopressin signaling in health and disease	20
To Ub or not to Ub: a regulatory question in TGF-β signaling	20
Advisory Board and Contents	20
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	20
How integrin phosphorylations regulate cell adhesion and signaling	20
Spray-type modifications: an emerging paradigm in post-translational modifications	19
Uncovering viral RNA–host cell interactions on a proteome-wide scale	19
Creating accessibility in academic negotiations	19
Cytoplasmic gene expression: lessons from poxviruses	19
Understanding the dynamic design of the spliceosome	19
Protein Termini 2022: central roles of protein ends	19
Maximizing grant funding: strategies for negotiating laboratory pricing	19
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	19
Enlightening epigenetics: optochemical tools illuminate the path	19
Subscription and Copyright Information	19
Biomolecules capturing live bacteria from clinical samples	18
Structural transitions modulate the chaperone activities of Grp94	18
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	18
Emerging structural insights into PRC2 function in development and disease	18
Exploring nondegrading molecular glues for protein–protein interactions	18
Regulation of plant NLRs by post-translational modifications	18
Subscription and Copyright Information	17
A vigilant gliding bird protects plants	17
Coupling lipid synthesis with nuclear envelope remodeling	17
Subscription and Copyright Information	17
Film-like organelles equip cells with multiple genetic codes	17
Thermal proteome profiling of protein-centric interactions and modifications	17
News about amino acid metabolism in plant–microbe interactions	17
Advisory Board and Contents	17
Using light to drive energy transduction in metazoan aging	17
Integrated approaches for discovery and functional annotation of proteins of unknown function	17
Advisory Board and Contents	17
Substrate and phosphorylation site selection by phosphoprotein phosphatases	16
Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design	16
Subscription and Copyright Information	16
Mitochondria in disease: changes in shapes and dynamics	16
The intersection of viral mimicry and nuclear entry	16
Structural advances in sterol-sensing domain-containing proteins	16
Subscription and Copyright Information	16
Subscription and Copyright Information	15
Advisory Board and Contents	15

Subscription and Copyright Information	15
Unlocking the protein code: how our organs age across a lifetime	14
Consequences of telomere replication failure: the other end-replication problem	14
Subscription and Copyright Information	14
Unlocking translational machinery for antitubercular drug development	14
Histone-mediated chromatin organization in prokaryotes and viruses	14
How do plants feel the heat and survive?	14
Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells	14
Microtubule specialization by +TIP networks: from mechanisms to functional implications	14
Advisory Board and Contents	14
Translational control through ribosome heterogeneity and functional specialization	14
From transcription to export: mRNA’s winding path to the cytoplasm	14
Giant variations in giant virus genome packaging	14
Subscription and Copyright Information	13
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?	13
Mechanisms and rationales of SAM homeostasis	13
Mining the gut microbiota for defluorination activity	13
The Integrator–PP2A complex integrates promoter-proximal premature termination with chromatin context and genome maintenance	13
The physiological relevance of autophagosome morphogenesis	13
Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier	13
The quest to identify ADP-ribosylation readers: methodological advances	13
Looking lively: emerging principles of pseudokinase signaling	13
Confluence and convergence of Dscam and Pcdh cell-recognition codes	13
LncRNAs: the missing link to senescence nuclear architecture	13
Mitochondrial heat production: the elephant in the lab…	13
Ensembles of synthetic polymers mimic biological fluids	12
ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising	12
Important questions and future directions in plant biochemistry	12
Assembling the jigsaw puzzle of life	12
Building a laboratory and networks during the COVID-19 pandemic	12
The metabolic cross-talk between cancer and T cells	12
Biogenesis and engineering of interleukin 12 family cytokines	12
Molecular determinants of protein evolvability	12
Subscription and Copyright Information	12
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions	12
Textbook oxidative phosphorylation needs to be rewritten	12
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain	12
Biosensor for monitoring PTEN activity in biological systems	12
RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer	11
Insights into mitoribosomal biogenesis from recent structural studies	11
Two for one: regulatory RNAs that encode small proteins	11
Back on the chain gang: polyphosphate modification of proteins	11
Coenzyme Q biochemistry and biosynthesis	11
The interplay of the cGAS–STING pathway with the lysosome	11
Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology	11
The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases	10
Chemical probes for imaging cellular compartmentalization	10
cAMP signaling: a remarkably regional affair	10
Chemical genetic methodologies for identifying protein substrates of PARPs	9
Subscription and Copyright Information	9
Trials and tribulations of statistical significance in biochemistry and omics	9
Advisory Board and Contents	9
Assembly and function of branched ubiquitin chains	9
Membranes as targets and modifiers of mutant huntingtin aggregation	9
Creating overview and summary figures	9
Subscription and Copyright Information	9
Mapping histone modification-dependent protein interactions with chemical proteomics	9
Contributions of single-particle cryoelectron microscopy toward fighting COVID-19	9
Size does matter: piRNA and miRNA targeting	9
Subscription and Copyright Information	9
Advisory Board and Contents	9
Mps1 kinase functions in mitotic spindle assembly and error correction	9
Understanding mitochondrial protein import: a revised model of the presequence translocase	9
Diverse lineages and adaptations of oxygen-adapted hydrogenases	9
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	8
Advisory Board and Contents	8
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	8
Z-DNA at the crossroads: untangling its role in genome dynamics	8
Chaperone-dependent and chaperone-independent functions of carboxylate clamp tetratricopeptide repeat (CC-TPR) proteins	8
Molecular design drives nanoarchitecture in self-assembling antimicrobial peptides	8
Frozen motion: how cryo-EM changes the way we look at ABC transporters	8
Joan J. Guinovart (1947–2025)	8
The emerging roles of S-acylation in autophagy	8
The multilayered regulation of aromatic amino acid biosynthesis in plants	8
Histone variants: expanding the epigenetic potential of neurons one amino acid at a time	7
Subscription and Copyright Information	7
Structural basis of torque generation in the bi-directional bacterial flagellar motor	7
IUBMB Trainee Initiative: supporting emerging biochemists and molecular biologists around the world	7
Methods for the directed evolution of biomolecular interactions	7
Endomembrane GPCR signaling: 15 years on, the quest continues	7
Machine learning and protein allostery	7
Advisory Board and Contents	7
PML isoforms: a molecular basis for PML pleiotropic functions	7
Subscription and Copyright Information	7
Recent structural advances towards understanding of the bacterial type III secretion injectisome	7
Advisory Board and Contents	7
Mammalian viral suppressors of RNA interference	7
Broadening access to cryoEM through centralized facilities	7
Mapping rRNA, tRNA, and mRNA modifications in ribosomes at high resolution	7
BRCA1/BARD1 is a nucleosome reader and writer	7
Advisory Board and Contents	6
Protein–membrane interactions: sensing and generating curvature	6
Efficient PROTAC-ing: combinational use of PROTACs with signaling pathway inhibitors	6
Targeting the nucleolus as a therapeutic strategy in human disease	6
Cell surface RNA biology: new roles for RNA binding proteins	6