Trends in Biochemical Sciences

Article	Citations
Advisory Board and Contents	492
Subscription and Copyright Information	243
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	213
Subscription and Copyright Information	136
Conserved signaling gears that sustain circadian clock robustness	133
Advisory Board and Contents	132
Harnessing the power of peptides: advances and collaborations in biochemistry	131
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	127
Understanding peptide hormones: from precursor proteins to bioactive molecules	115
Exploiting enzyme evolution for computational protein design	110
Adding post-translational modifications and protein–protein interactions to protein schematics	106
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	102
Cellular oxidants and the proteostasis network: balance between activation and destruction	102
Did circular DNA shape the evolution of mammalian genomes?	93
Novel machine learning approaches revolutionize protein knowledge	85
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	80
Parallels and crosstalk of ADP-ribosylation and ubiquitination	77
Decoding ceramide function: how localization shapes cellular fate and how to study it	75
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	71
Multiplayer virtual reality for understanding biomolecular structures	69
From lead to market: chemical approaches to transform peptides into therapeutics	69
Subconductance states add complexity to Piezo1 gating model	67
Microtubule nucleation for spindle assembly: one molecule at a time	66
Creative approaches using proximity labeling to gain new biological insights	65
Mobile peptide and receptor complex mediates systemic stomatal immunity	64

Mitochondrial dynamics and pore formation in regulated cell death pathways	62
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	61
Exploring membrane asymmetry and its effects on membrane proteins	59
Transcription-coupled nucleosome assembly	59
Autophagy regulation by phase separation, avidity, and wetting	58
Proteasome-derived peptides: separating the trash from the recycling	56
Bacterial transformation	55
The transition phase: preparing to launch a laboratory	54
Using graphs and charts in scientific figures	54
Determining and interpreting protein lifetimes in mammalian tissues	53
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	53
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	52
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	50
Activation, decommissioning, and dememorization: enhancers in a life cycle	50
Transcription-coupled global genomic repair in E. coli	49
Challenges of biomolecular science education in Africa and the way forward	49
Diverse heterochromatin states restricting cell identity and reprogramming	48
Glucokinase: from allosteric glucose sensing to disease variants	48
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	44
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	43
Two hearts beat as one: the debate over RAS dimers continues	43
Subscription and Copyright Information	43
A plant immune protein fights against cancer	42
Advisory Board and Contents	42
An outreach activity to enhance biochemistry pedagogy	42
Making nucleic acid structures and schematics	42
Seeing the forest through the trees: characterizing the glycoproteome	41
Thiol dioxygenases: from structures to functions	40
The RNA tether model for human chromosomal translocation fragile zones	40
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	39
Making ends meet: a universal driver of large ribosomal subunit biogenesis	37
Just bypass it: mechanisms of DNA damage tolerance	37
Engineering RiPP pathways: strategies for generating complex bioactive peptides	36
The metabolic code of ferroptosis: nutritional regulators of cell death	36
Pyruvylation: a link bridging metabolic disorders and impaired antiviral immunity	35
Innovations in the electron transport chain fuel archaeal methane metabolism	35
Tandem repeats matter for the functional versatility of giant proteins	34
Adenosine signals an imbalance between activity and supply in privileged cells	34
Control of chloroplast degradation and cell death in response to stress	34
Zn2+ transients and signaling in mammalian systems	33
Functional modulation of chemical mediators in microbial communities	33
Convergent evolution in two bacterial replicative helicase loaders	33
The expanding landscape of canonical and non-canonical protein phosphorylation	33
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	33
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Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	32
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Rethinking transcription factor dynamics and transcription regulation in eukaryotes	32
Non-histone binding functions of PHD fingers	32

Metamorphic protein folding as evolutionary adaptation	32
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Decoding disease-relevant variants with base and prime editors at scale	31
Advisory Board and Contents	30
Programmable protein editing	30
Liquid–liquid phase separation in presynaptic nerve terminals	30
Advisory Board and Contents	30
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	30
Does chromatin function as a metabolite reservoir?	30
Time-resolved serial crystallography to reveal protein structural changes	29
TiBS at 50	28
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
CryoEM shows the active dynein complex on microtubules	28
The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine	28
Forging a path toward a more sustainable laboratory	28
The crosstalk of m6A-modified RNA with DNA damage repair	27
Orange carotenoid proteins: structural understanding of evolution and function	27
Proteostasis in cellular dormancy: lessons from yeast to oocytes	27
Recent advances in enzymes active on lignin-derived aromatic compounds	26
Cooperative assembly of the mitochondrial respiratory chain	26
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Functional insights into the nitrogenase-like enzyme superfamily	25
Multifaceted control of T cell differentiation by STIM1	25
Monitoring subcellular NADP redox state with NAPstar biosensors	24
Lysines and cysteines: partners in stress?	24
Advisory Board and Contents	24
Computationally guided AAV engineering for enhanced gene delivery	24
E3 ubiquitin ligases in signaling, disease, and therapeutics	23
Advancing nanopore technology toward protein identification and sequencing	23
Powerful polymerases synthesize labeled RNA better, faster, stronger	23
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	23
TRAPs: the ‘elevator-with-an-operator’ mechanism	23
Advances, challenges, and opportunities in structural biology	23
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	22
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	22
Advances in understanding aryl hydrocarbon receptor structure, function, and modulation	22
FN3K: the (un)sweetest kinase	22
Advisory Board and Contents	22
Subscription and Copyright Information	22
Synaptoneurolipidomics: lipidomics in the study of synaptic function	21
Protein SUMOylation and phase separation: partners in stress?	21
Wrapping up a special series on scientific figure development	21
Discovering riboswitches: the past and the future	21
How to compile different types of structural visualizations in one panel	21
Oxytocin and vasopressin signaling in health and disease	21
Endogenous plant nitroxyl, a new component of nitric oxide biology	21
Discordant skeletal muscle gene and protein responses to exercise	20
To Ub or not to Ub: a regulatory question in TGF-β signaling	20
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	20
Advisory Board and Contents	20
SRC homology 3 domains: multifaceted binding modules	20
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	20
Regulation of plant NLRs by post-translational modifications	19
Maximizing grant funding: strategies for negotiating laboratory pricing	19
Creating accessibility in academic negotiations	19
Spray-type modifications: an emerging paradigm in post-translational modifications	19
Emerging structural insights into PRC2 function in development and disease	19
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	19
Enlightening epigenetics: optochemical tools illuminate the path	19
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The past, present, and future of RNA biochemistry and mitochondrial research	18
Biomolecules capturing live bacteria from clinical samples	18
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	18
Cytoplasmic gene expression: lessons from poxviruses	18
Exploring nondegrading molecular glues for protein–protein interactions	18
Understanding the dynamic design of the spliceosome	18
Protein Termini 2022: central roles of protein ends	18
Structural transitions modulate the chaperone activities of Grp94	18
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Advisory Board and Contents	17
Film-like organelles equip cells with multiple genetic codes	16
Integrated approaches for discovery and functional annotation of proteins of unknown function	16
Substrate and phosphorylation site selection by phosphoprotein phosphatases	16
Advisory Board and Contents	16
Adenosylhomocysteinase–adenosine complex links m6A and cancer lipid metabolism	16
Thermal proteome profiling of protein-centric interactions and modifications	16
A vigilant gliding bird protects plants	16
Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease	16
Inspiring discovery through reviews and visualization in biochemistry	15

Mitochondria in disease: changes in shapes and dynamics	15
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News about amino acid metabolism in plant–microbe interactions	15
The intersection of viral mimicry and nuclear entry	15
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Cytosolic AcCoA: a metabolic signal bridging nutrient sensing and mitophagy	15
Using light to drive energy transduction in metazoan aging	15
Unlocking the protein code: how our organs age across a lifetime	15
Consequences of telomere replication failure: the other end-replication problem	14
Advisory Board and Contents	14
Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design	14
Histone-mediated chromatin organization in prokaryotes and viruses	14
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Advisory Board and Contents	14
From transcription to export: mRNA’s winding path to the cytoplasm	14
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Microtubule specialization by +TIP networks: from mechanisms to functional implications	14
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Systems-level modeling: Capturing the true complexity of disease	13
Modifying the modifiers: ubiquitination of ADP-ribosylation in human cells	13
The metabolic cross-talk between cancer and T cells	13
Mining the gut microbiota for defluorination activity	13
Unlocking translational machinery for antitubercular drug development	13
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Mitochondrial heat production: the elephant in the lab…	13
The quest to identify ADP-ribosylation readers: methodological advances	13
How do plants feel the heat and survive?	13
Confluence and convergence of Dscam and Pcdh cell-recognition codes	12
The physiological relevance of autophagosome morphogenesis	12
LncRNAs: the missing link to senescence nuclear architecture	12
The Integrator–PP2A complex integrates promoter-proximal premature termination with chromatin context and genome maintenance	12
Structural transport and inhibition mechanism of the mitochondrial pyruvate carrier	12
Mechanisms and rationales of SAM homeostasis	12
Giant variations in giant virus genome packaging	12
Looking lively: emerging principles of pseudokinase signaling	12
Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions	12
Subscription and Copyright Information	11
Ensembles of synthetic polymers mimic biological fluids	11
Important questions and future directions in plant biochemistry	11
Biosensor for monitoring PTEN activity in biological systems	11
Keeping neuronal activity in check: a novel role for α-synuclein serine-129 phosphorylation in the healthy brain	11
Assembling the jigsaw puzzle of life	11
Biogenesis and engineering of interleukin 12 family cytokines	11
The interplay of the cGAS–STING pathway with the lysosome	11
Insights into 4-hydroxyphenylpyruvate dioxygenase-inhibitor interactions from comparative structural biology	11
Insights into mitoribosomal biogenesis from recent structural studies	11
Anti-type VI tactics: bacterial defenses against type VI secretion system attacks	11
Textbook oxidative phosphorylation needs to be rewritten	11
ERK-dependent protein phosphorylation in KRAS-mutant cancer: a mix of the expected and surprising	10
The COP9 signalosome: A versatile regulatory hub of Cullin-RING ligases	10
cAMP signaling: a remarkably regional affair	10
Molecular determinants of protein evolvability	10
Back on the chain gang: polyphosphate modification of proteins	10
Coenzyme Q biochemistry and biosynthesis	10
Two for one: regulatory RNAs that encode small proteins	9
Creating overview and summary figures	9
Membranes as targets and modifiers of mutant huntingtin aggregation	9
Building a laboratory and networks during the COVID-19 pandemic	9
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Advisory Board and Contents	9
RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer	9
Advisory Board and Contents	9
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Z-DNA at the crossroads: untangling its role in genome dynamics	8
Molecular design drives nanoarchitecture in self-assembling antimicrobial peptides	8
Musings of a lab janitor: AI shenanigans	8
Chemical genetic methodologies for identifying protein substrates of PARPs	8
Diverse lineages and adaptations of oxygen-adapted hydrogenases	8
Mps1 kinase functions in mitotic spindle assembly and error correction	8
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	8
Fine-tuning the connection between photorespiration and one-carbon metabolism	8
The multifunctional, stress-sensitive ribonuclease angiogenin cross-regulates different gene expression processes	8
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	8
The multilayered regulation of aromatic amino acid biosynthesis in plants	8
Chemical probes for imaging cellular compartmentalization	8
Trials and tribulations of statistical significance in biochemistry and omics	8
The emerging roles of S-acylation in autophagy	7
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Histone variants: expanding the epigenetic potential of neurons one amino acid at a time	7
Understanding mitochondrial protein import: a revised model of the presequence translocase	7
Advisory Board and Contents	7
Joan J. Guinovart (1947–2025)	7
PML isoforms: a molecular basis for PML pleiotropic functions	7
Assembly and function of branched ubiquitin chains	7
Advisory Board and Contents	7
Advisory Board and Contents	7
Epigenetic regulation of circadian clocks by chromatin dynamics from fungi to mammals	7
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Methods for the directed evolution of biomolecular interactions	6
mRNA accessibility within mRNPs as a determinant of gene expression	6
Machine learning and protein allostery	6
Mapping rRNA, tRNA, and mRNA modifications in ribosomes at high resolution	6
IUBMB Trainee Initiative: supporting emerging biochemists and molecular biologists around the world	6
Advancing sustainable biotechnology through protein engineering	6