OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Subscription and Copyright Information	321
Subscription and Copyright Information	187
Subscription and Copyright Information	160
Adding post-translational modifications and protein–protein interactions to protein schematics	150
Advisory Board and Contents	147
Multiplayer virtual reality for understanding biomolecular structures	146
Understanding peptide hormones: from precursor proteins to bioactive molecules	145
Harnessing the power of peptides: advances and collaborations in biochemistry	121
Advisory Board and Contents	110
Transporter Specificity: A Tale of Loosened Elevator-Sliding	101
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	98
Conserved signaling gears that sustain circadian clock robustness	96
Novel machine learning approaches revolutionize protein knowledge	95
Decoding ceramide function: how localization shapes cellular fate and how to study it	91
Did circular DNA shape the evolution of mammalian genomes?	89
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	88
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	87
Cellular oxidants and the proteostasis network: balance between activation and destruction	85
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	78
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	78
From lead to market: chemical approaches to transform peptides into therapeutics	77
Molecular mechanisms of heat shock factor 1 regulation	75
Transcription-coupled global genomic repair in E. coli	70
Exploiting enzyme evolution for computational protein design	70
Structural parasitology of the malaria parasite Plasmodium falciparum	69

Using graphs and charts in scientific figures	69
Determining and interpreting protein lifetimes in mammalian tissues	69
Subconductance states add complexity to Piezo1 gating model	67
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	66
The transition phase: preparing to launch a laboratory	66
Transcription-coupled nucleosome assembly	60
Exploring membrane asymmetry and its effects on membrane proteins	59
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	58
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	58
Proteasome-derived peptides: separating the trash from the recycling	57
Creative approaches using proximity labeling to gain new biological insights	56
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	56
Activation, decommissioning, and dememorization: enhancers in a life cycle	54
Glucokinase: from allosteric glucose sensing to disease variants	53
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	52
Cell entry by SARS-CoV-2	51
Microtubule nucleation for spindle assembly: one molecule at a time	51
Diverse heterochromatin states restricting cell identity and reprogramming	50
Advisory Board and Contents	49
Apart, together	49
Engineering RiPP pathways: strategies for generating complex bioactive peptides	47
Subscription and Copyright Information	46
The metabolic code of ferroptosis: nutritional regulators of cell death	46
Making nucleic acid structures and schematics	45
Two hearts beat as one: the debate over RAS dimers continues	44
An outreach activity to enhance biochemistry pedagogy	43
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	43
A plant immune protein fights against cancer	43
Control of chloroplast degradation and cell death in response to stress	42
Thiol dioxygenases: from structures to functions	42
The expanding landscape of canonical and non-canonical protein phosphorylation	40
Making ends meet: a universal driver of large ribosomal subunit biogenesis	39
Innovations in the electron transport chain fuel archaeal methane metabolism	39
The RNA tether model for human chromosomal translocation fragile zones	38
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	38
Mitochondrial compartmentalization: emerging themes in structure and function	38
Seeing the forest through the trees: characterizing the glycoproteome	38
Functional modulation of chemical mediators in microbial communities	37
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	37
Subscription and Copyright Information	36
Subscription and Copyright Information	35
Cloud computing platforms to support cryo-EM structure determination	34
Convergent evolution in two bacterial replicative helicase loaders	33
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	33
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	33
Non-histone binding functions of PHD fingers	32
Liquid–liquid phase separation in presynaptic nerve terminals	32
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	31
Origins and evolving functionalities of tRNA-derived small RNAs	30
Metamorphic protein folding as evolutionary adaptation	29

Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	29
Cooperative assembly of the mitochondrial respiratory chain	28
Subscription and Copyright Information	28
Advisory Board and Contents	28
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
Time-resolved serial crystallography to reveal protein structural changes	28
CryoEM shows the active dynein complex on microtubules	28
Advisory Board and Contents	27
Does chromatin function as a metabolite reservoir?	27
Multifaceted control of T cell differentiation by STIM1	27
Recent advances in enzymes active on lignin-derived aromatic compounds	27
The crosstalk of m6A-modified RNA with DNA damage repair	27
Forging a path toward a more sustainable laboratory	26
Lamin post-translational modifications: emerging toggles of nuclear organization and function	26
Proteostasis in cellular dormancy: lessons from yeast to oocytes	26
Programmable protein editing	26
Advances, challenges, and opportunities in structural biology	25
Lysines and cysteines: partners in stress?	25
Monitoring subcellular NADP redox state with NAPstar biosensors	25
Advancing nanopore technology toward protein identification and sequencing	25
Circular RNAs in physiology and non-immunological diseases	25
Orange carotenoid proteins: structural understanding of evolution and function	25
Computationally guided AAV engineering for enhanced gene delivery	24
Subscription and Copyright Information	24
Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	24
TRAPs: the ‘elevator-with-an-operator’ mechanism	24
Lipidation status of single membrane-associated ATG8 proteins	23
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	23
Wrapping up a special series on scientific figure development	23
Protein SUMOylation and phase separation: partners in stress?	23
Subscription and Copyright Information	23
FN3K: the (un)sweetest kinase	22
To Ub or not to Ub: a regulatory question in TGF-β signaling	22
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	22
Endogenous plant nitroxyl, a new component of nitric oxide biology	22
How to compile different types of structural visualizations in one panel	22
Oxytocin and vasopressin signaling in health and disease	21
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	21
Discordant skeletal muscle gene and protein responses to exercise	21
How integrin phosphorylations regulate cell adhesion and signaling	21
Synaptoneurolipidomics: lipidomics in the study of synaptic function	20
Subscription and Copyright Information	20
SRC homology 3 domains: multifaceted binding modules	20
Protein Termini 2022: central roles of protein ends	20
Discovering riboswitches: the past and the future	20
Advisory Board and Contents	20
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	20
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	19
Creating accessibility in academic negotiations	18
Spray-type modifications: an emerging paradigm in post-translational modifications	18
Mitochondrial DNA: cellular genotoxic stress sentinel	18
Enlightening epigenetics: optochemical tools illuminate the path	18
Maximizing grant funding: strategies for negotiating laboratory pricing	18
Biomolecules capturing live bacteria from clinical samples	18
Structural transitions modulate the chaperone activities of Grp94	18
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	18
Advisory Board and Contents	17
Uncovering viral RNA–host cell interactions on a proteome-wide scale	17
Take Your PIC	17
Subscription and Copyright Information	17
Understanding the dynamic design of the spliceosome	17
More Than Just Closed and Open: Unraveling a Mechanosensor	17
Regulation of Autophagy Enzymes by Nutrient Signaling	17
Cytoplasmic gene expression: lessons from poxviruses	17
Transforming eukaryotic cell culture with macromolecular crowding	16
Structural advances in sterol-sensing domain-containing proteins	16
A vigilant gliding bird protects plants	16
Film-like organelles equip cells with multiple genetic codes	16
Subscription and Copyright Information	16
Advisory Board and Contents	16
Advisory Board and Contents	16
Thermal proteome profiling of protein-centric interactions and modifications	16
Using light to drive energy transduction in metazoan aging	16