OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Subscription and Copyright Information	330
Capturing 3D macromolecule structure in 2D images	238
Lipidation status of single membrane-associated ATG8 proteins	214
Hypoxia research, where to now?	150
Synaptoneurolipidomics: lipidomics in the study of synaptic function	147
Decoding ceramide function: how localization shapes cellular fate and how to study it	143
A wrinkle in timers: evolutionary rewiring of conserved biological timekeepers	136
Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications	131
From lead to market: chemical approaches to transform peptides into therapeutics	131
SRC homology 3 domains: multifaceted binding modules	125
Transporter Specificity: A Tale of Loosened Elevator-Sliding	119
Subscription and Copyright Information	111
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	105
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	94
Oxytocin and vasopressin signaling in health and disease	89
A special series on scientific figure development	88
Subscription and Copyright Information	85
Recruiting women faculty through inclusive, family-friendly practices	84
How to compile different types of structural visualizations in one panel	83
Chemical probes for imaging cellular compartmentalization	81
New paradigm for teaching scientific writing in STEM	80
Turning science into cover art	79
Subscription and Copyright Information	79
A NuRD for all seasons	77
One Ring to Rule them All? Structural and Functional Diversity in the Nuclear Pore Complex	77

Creating overview and summary figures	72
Z-DNA at the crossroads: untangling its role in genome dynamics	72
Advisory Board and Contents	71
Depicting protein structures as schematics	71
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	67
Subscription and Copyright Information	65
Subscription and Copyright Information	64
Subscription and Copyright Information	63
To Ub or not to Ub: a regulatory question in TGF-β signaling	63
Adding post-translational modifications and protein–protein interactions to protein schematics	63
Subscription and Copyright Information	62
RNA levers and switches controlling viral gene expression	62
Wrapping up a special series on scientific figure development	62
Subscription and Copyright Information	61
Mps1 kinase functions in mitotic spindle assembly and error correction	57
Physiological media advance cell culture experiments	57
Immunometabolism in atherosclerosis: a new understanding of an old disease	54
Discordant skeletal muscle gene and protein responses to exercise	53
Exploring cross-α amyloids: from functional roles to design innovations	53
Migrasome biogenesis: when biochemistry meets biophysics on membranes	52
Trials and tribulations of statistical significance in biochemistry and omics	51
Size does matter: piRNA and miRNA targeting	49
Microbial Prions: Dawn of a New Era	48
The Spatial Organization of Sister Chromatids	48
On the Cutting Edge: Regulation and Therapeutic Potential of the mRNA 3′ End Nuclease	46
Seeing Atoms by Single-Particle Cryo-EM	45
Closing the structure-to-function gap for LRRK2	45
Chemical genetic methodologies for identifying protein substrates of PARPs	44
A ‘NAC’ for targeting proteins to the ER	43
Contributions of single-particle cryoelectron microscopy toward fighting COVID-19	43
Mapping histone modification-dependent protein interactions with chemical proteomics	42
Kinetics of RNA–protein interactions in cells	42
Substrate recognition and transport mechanism of the PIN-FORMED auxin exporters	41
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	41
Targeting protein conformations with small molecules to control protein complexes	41
A kinetic mechanism for systems-level behavior in GTPase signaling	41
Multiplayer virtual reality for understanding biomolecular structures	40
A left-handed RNA quadruplex directs gene silencing	40
Protein SUMOylation and phase separation: partners in stress?	39
Diseases caused by altered specificity of a protein kinase for its allosteric activators	39
Ubiquitin system mutations in neurological diseases	39
Revealing eEF-2 kinase: recent structural insights into function	39
AI interprets the Central Dogma and Genetic Code	38
The role of hydrolysis in perceiving and degrading the plant hormone strigolactones	38
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	36
Exploring protein conformations with limited proteolysis coupled to mass spectrometry	36
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	36
Assembly and function of branched ubiquitin chains	35
Novel machine learning approaches revolutionize protein knowledge	35
Did circular DNA shape the evolution of mammalian genomes?	34

DNA segregation in mitochondria and beyond: insights from the trypanosomal tripartite attachment complex	34
Through the looking glass: milestones on the road towards mirroring life	34
Structural Basis for the Modulation of Ryanodine Receptors	34
Cryo-electron tomography of enveloped viruses	33
Canary in a coal mine: collided ribosomes as sensors of cellular conditions	33
How integrin phosphorylations regulate cell adhesion and signaling	32
Proteasome substrate receptors and their therapeutic potential	32
Cellular oxidants and the proteostasis network: balance between activation and destruction	31
NAD-capped RNAs – a redox cofactor meets RNA	30
Endogenous plant nitroxyl, a new component of nitric oxide biology	30
Frozen motion: how cryo-EM changes the way we look at ABC transporters	30
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	30
Protein kinase C: release from quarantine by mTORC2	30
Molecular mechanisms of heat shock factor 1 regulation	26
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	26
Understanding mitochondrial protein import: a revised model of the presequence translocase	26
Coordinating gene expression during the cell cycle	26
Discovering riboswitches: the past and the future	25
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	25
The NLRP3 inflammasome: activation and regulation	25
Exploiting enzyme evolution for computational protein design	24
Discovery, biochemical characterization, and bioengineering of cyanobactin prenyltransferases	23
Plant-based carboxysomes: another step toward increased crop yields	23
Biomolecules capturing live bacteria from clinical samples	23
Advisory Board and Contents	22
In vivo single-molecule RNA structural profiling	22
Advisory Board and Contents	22
Advisory Board and Contents	22
Seeing smell: the structural underpinnings of insect olfaction	22
Advisory Board and Contents	21
Advisory Board and Contents	21
(G)Patching up mis-splicing in cancer	21
Subscription and Copyright Information	20
Pushing boundaries of cryo-EM	20
Advisory Board and Contents	20
Subscription and Copyright Information	20
Subscription and Copyright Information	20
Subscription and Copyright Information	20
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	19
Subscription and Copyright Information	19
Advisory Board and Contents	19
Presenting technological workflows	19
Protein Termini 2022: central roles of protein ends	19
Advisory Board and Contents	19
Subscription and Copyright Information	19
The transition phase: preparing to launch a laboratory	19
Pre-twisting for improved genome modification and miRNA targeting	19
Maximizing grant funding: strategies for negotiating laboratory pricing	19
A new path for terpenoid biosynthesis	18
A physicochemical perspective on cellular ageing	18
The Hammer and the Dance of Cell Cycle Control	18
cCMP and cUMP come into the spotlight, finally	18
Limitations in membrane protein structure determination by lipid nanodiscs	18
Advisory Board and Contents	18
Characterizing Circular RNAs Using Nanopore Sequencing	17
The Life Cycle of the Mu-Opioid Receptor	17
Interplay of cGAS with chromatin	17
Crosslinking and Mass Spectrometry to Identify Regulators in Unconventional Secretion	17
PML isoforms: a molecular basis for PML pleiotropic functions	17
Membrane protein synthesis: no cells required	17
Completing the canvas: advances and challenges for DNA-PAINT super-resolution imaging	17
Chemoproteomic approach for mapping binding sites of post-translational-modification-mediated protein–protein interactions	17
Microtubule nucleation for spindle assembly: one molecule at a time	16
High-throughput approaches to understand and engineer bacteriophages	16
Spray-type modifications: an emerging paradigm in post-translational modifications	16
Feeling the heat: how chaperones deal with biomolecular condensates	16
Transcription-coupled global genomic repair in E. coli	16
Mammalian viral suppressors of RNA interference	16
Creating accessibility in academic negotiations	16
Helicases clear hurdles during plant defense protein translation	15
The Leishmania ribosome: more than passive mRNA translating machinery	15
Protein lipoylation: mitochondria, cuproptosis, and beyond	15
Defining the commonalities between post-transcriptional and post-translational modification communities	15
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	15
ULK/Atg1: phasing in and out of autophagy	15