OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Advisory Board and Contents	394
Adding post-translational modifications and protein–protein interactions to protein schematics	214
Subscription and Copyright Information	186
Multiplayer virtual reality for understanding biomolecular structures	176
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	113
Subscription and Copyright Information	110
Subscription and Copyright Information	108
Novel machine learning approaches revolutionize protein knowledge	105
Conserved signaling gears that sustain circadian clock robustness	101
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	100
Advisory Board and Contents	96
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	91
Harnessing the power of peptides: advances and collaborations in biochemistry	91
Exploiting enzyme evolution for computational protein design	87
From lead to market: chemical approaches to transform peptides into therapeutics	87
Decoding ceramide function: how localization shapes cellular fate and how to study it	84
Did circular DNA shape the evolution of mammalian genomes?	81
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	76
Cellular oxidants and the proteostasis network: balance between activation and destruction	75
Understanding peptide hormones: from precursor proteins to bioactive molecules	70
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	69
Molecular mechanisms of heat shock factor 1 regulation	66
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	66
Transcription-coupled nucleosome assembly	65
Proteasome-derived peptides: separating the trash from the recycling	65

Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	63
Subconductance states add complexity to Piezo1 gating model	62
Using graphs and charts in scientific figures	61
The transition phase: preparing to launch a laboratory	60
Structural parasitology of the malaria parasite Plasmodium falciparum	57
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	57
Transcription-coupled global genomic repair in E. coli	56
Mitochondrial dynamics and pore formation in regulated cell death pathways	52
Activation, decommissioning, and dememorization: enhancers in a life cycle	52
Glucokinase: from allosteric glucose sensing to disease variants	51
Autophagy regulation by phase separation, avidity, and wetting	51
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	50
Creative approaches using proximity labeling to gain new biological insights	50
Exploring membrane asymmetry and its effects on membrane proteins	49
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	49
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	48
Diverse heterochromatin states restricting cell identity and reprogramming	46
Determining and interpreting protein lifetimes in mammalian tissues	45
Microtubule nucleation for spindle assembly: one molecule at a time	45
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	43
Two hearts beat as one: the debate over RAS dimers continues	43
Thiol dioxygenases: from structures to functions	43
Subscription and Copyright Information	43
An outreach activity to enhance biochemistry pedagogy	42
Apart, together	42
A plant immune protein fights against cancer	42
Seeing the forest through the trees: characterizing the glycoproteome	40
Advisory Board and Contents	40
Control of chloroplast degradation and cell death in response to stress	40
Making nucleic acid structures and schematics	40
Making ends meet: a universal driver of large ribosomal subunit biogenesis	39
The RNA tether model for human chromosomal translocation fragile zones	39
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	39
Functional modulation of chemical mediators in microbial communities	38
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	36
Engineering RiPP pathways: strategies for generating complex bioactive peptides	36
Just bypass it: mechanisms of DNA damage tolerance	36
Innovations in the electron transport chain fuel archaeal methane metabolism	36
The metabolic code of ferroptosis: nutritional regulators of cell death	35
The expanding landscape of canonical and non-canonical protein phosphorylation	35
Convergent evolution in two bacterial replicative helicase loaders	32
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	32
Liquid–liquid phase separation in presynaptic nerve terminals	32
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	32
Subscription and Copyright Information	31
Cloud computing platforms to support cryo-EM structure determination	31
Metamorphic protein folding as evolutionary adaptation	30
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	30
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	30
Non-histone binding functions of PHD fingers	30

Subscription and Copyright Information	30
Zn2+ transients and signaling in mammalian systems	30
Advisory Board and Contents	29
Advisory Board and Contents	29
Orange carotenoid proteins: structural understanding of evolution and function	28
Multifaceted control of T cell differentiation by STIM1	28
CryoEM shows the active dynein complex on microtubules	28
Recent advances in enzymes active on lignin-derived aromatic compounds	27
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	27
Cooperative assembly of the mitochondrial respiratory chain	26
Proteostasis in cellular dormancy: lessons from yeast to oocytes	26
Circular RNAs in physiology and non-immunological diseases	26
Does chromatin function as a metabolite reservoir?	26
Programmable protein editing	26
The crosstalk of m6A-modified RNA with DNA damage repair	26
Time-resolved serial crystallography to reveal protein structural changes	26
Forging a path toward a more sustainable laboratory	26
Computationally guided AAV engineering for enhanced gene delivery	25
Subscription and Copyright Information	25
Lysines and cysteines: partners in stress?	25
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	25
Monitoring subcellular NADP redox state with NAPstar biosensors	24
Protein SUMOylation and phase separation: partners in stress?	24
Advances, challenges, and opportunities in structural biology	24
E3 ubiquitin ligases in signaling, disease, and therapeutics	24
FN3K: the (un)sweetest kinase	24
Advancing nanopore technology toward protein identification and sequencing	24
TRAPs: the ‘elevator-with-an-operator’ mechanism	24
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	24
How integrin phosphorylations regulate cell adhesion and signaling	23
Synaptoneurolipidomics: lipidomics in the study of synaptic function	23
Discovering riboswitches: the past and the future	23
Discordant skeletal muscle gene and protein responses to exercise	23
Oxytocin and vasopressin signaling in health and disease	22
Subscription and Copyright Information	21
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	21
Endogenous plant nitroxyl, a new component of nitric oxide biology	20
How to compile different types of structural visualizations in one panel	20
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	20
Wrapping up a special series on scientific figure development	20
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	20
Uncovering viral RNA–host cell interactions on a proteome-wide scale	19
SRC homology 3 domains: multifaceted binding modules	19
Protein Termini 2022: central roles of protein ends	19
Advisory Board and Contents	19
Structural transitions modulate the chaperone activities of Grp94	19
To Ub or not to Ub: a regulatory question in TGF-β signaling	19
Cytoplasmic gene expression: lessons from poxviruses	18
Spray-type modifications: an emerging paradigm in post-translational modifications	18
Biomolecules capturing live bacteria from clinical samples	18
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	18
Enlightening epigenetics: optochemical tools illuminate the path	18
Maximizing grant funding: strategies for negotiating laboratory pricing	18
Exploring nondegrading molecular glues for protein–protein interactions	18
Subscription and Copyright Information	18
Creating accessibility in academic negotiations	18
Understanding the dynamic design of the spliceosome	18
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	18
Advisory Board and Contents	17
Subscription and Copyright Information	17
A vigilant gliding bird protects plants	17
Film-like organelles equip cells with multiple genetic codes	17
Advisory Board and Contents	17
Using light to drive energy transduction in metazoan aging	17
Regulation of plant NLRs by post-translational modifications	17
Subscription and Copyright Information	17
Mitochondria in disease: changes in shapes and dynamics	16
Integrated approaches for discovery and functional annotation of proteins of unknown function	16
Structural advances in sterol-sensing domain-containing proteins	16
News about amino acid metabolism in plant–microbe interactions	16
Substrate and phosphorylation site selection by phosphoprotein phosphatases	16
Coupling lipid synthesis with nuclear envelope remodeling	16
The lysosome as a master regulator of iron metabolism	16
Thermal proteome profiling of protein-centric interactions and modifications	16