OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Biomolecular Condensates in the Nucleus	261
Mitochondrial Dysfunction and Mitophagy in Parkinson’s Disease: From Mechanism to Therapy	245
Mechanisms and Functions of Chromosome Compartmentalization	161
FUS and TDP-43 Phases in Health and Disease	156
Mechanisms and Regulation of RNA Condensation in RNP Granule Formation	132
Senescent Cells: Emerging Targets for Human Aging and Age-Related Diseases	128
Reciprocal Regulation of Mitochondrial Fission and Fusion	125
Hippo Signaling in Embryogenesis and Development	125
Cell entry by SARS-CoV-2	120
Autophagy Assays for Biological Discovery and Therapeutic Development	107
Single-Cell Proteomics	97
G-Quadruplexes in RNA Biology: Recent Advances and Future Directions	96
Outlining the Complex Pathway of Mammalian Fe-S Cluster Biogenesis	90
The NLRP3 inflammasome: activation and regulation	87
YAP and TAZ Are Not Identical Twins	86
How Lysosomes Sense, Integrate, and Cope with Stress	85
Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels	81
Location, Location, Location: Compartmentalization of NAD+ Synthesis and Functions in Mammalian Cells	80
Cytosolic Events in the Biogenesis of Mitochondrial Proteins	80
Origins and evolving functionalities of tRNA-derived small RNAs	79
The lysosome as a master regulator of iron metabolism	79
Coordinating gene expression during the cell cycle	78
ADAR RNA Modifications, the Epitranscriptome and Innate Immunity	75
Natural Compounds as Pharmaceuticals: The Key Role of Cytochromes P450 Reactivity	74
Making the Case for Disordered Proteins and Biomolecular Condensates in Bacteria	74

Discovering riboswitches: the past and the future	70
Beyond Autophagy: The Expanding Roles of ATG8 Proteins	69
Extracellular miRNAs and Cell–Cell Communication: Problems and Prospects	68
Myristoylation, an Ancient Protein Modification Mirroring Eukaryogenesis and Evolution	68
ER-Phagy, ER Homeostasis, and ER Quality Control: Implications for Disease	67
Mechanisms of Long Noncoding RNA Nuclear Retention	65
Coupling of Ribosome Synthesis and Translational Capacity with Cell Growth	64
One Ring to Rule them All? Structural and Functional Diversity in the Nuclear Pore Complex	64
Nothing Is Yet Set in (Hi)stone: Novel Post-Translational Modifications Regulating Chromatin Function	63
Circular RNAs in Immune Response and Viral Infection	62
The Golgi as an Assembly Line to the Autophagosome	60
Mechanistic Insights into the Generation and Transduction of Hedgehog Signaling	60
Emerging Insights into the Structure and Function of Complement C5a Receptors	58
A Chain of Events: Regulating Target Proteins by SUMO Polymers	58
Chromatin Regulation through Ubiquitin and Ubiquitin-like Histone Modifications	58
Direct Structural Insights into GABAA Receptor Pharmacology	58
Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function	57
Histone Tail Conformations: A Fuzzy Affair with DNA	57
Activation and Regulation of Cytoplasmic Dynein	56
Metabolism and the Epigenome: A Dynamic Relationship	55
Biomolecular Condensates and Their Links to Cancer Progression	54
Rapid Detection and Signaling of DNA Damage by PARP-1	53
Phytochemicals as Prebiotics and Biological Stress Inducers	53
Translational control through ribosome heterogeneity and functional specialization	52
Protein N-Terminal Acetylation: Structural Basis, Mechanism, Versatility, and Regulation	51
Mitochondrial DNA: cellular genotoxic stress sentinel	50
Regulation of Autophagy Enzymes by Nutrient Signaling	50
The Retromer Complex: From Genesis to Revelations	47
How do plants feel the heat and survive?	47
Drug discovery in the era of cryo-electron microscopy	46
Molecular mechanisms of heat shock factor 1 regulation	46
A Tour of TOR Complex Signaling in Plants	46
Revisiting Extracellular RNA Release, Processing, and Function	45
The Wide World of Coacervates: From the Sea to Neurodegeneration	45
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	44
Mitochondrial-to-nuclear communication in aging: an epigenetic perspective	44
Molecular Determinants of Flavivirus Virion Assembly	43
Nonredundant Roles of GRASP55 and GRASP65 in the Golgi Apparatus and Beyond	43
Chaperone Machineries of Rubisco – The Most Abundant Enzyme	43
Assembly and function of branched ubiquitin chains	42
Genetically Encodable Fluorescent and Bioluminescent Biosensors Light Up Signaling Networks	42
The Hammer and the Dance of Cell Cycle Control	42
News about amino acid metabolism in plant–microbe interactions	41
DEAH-Box RNA Helicases in Pre-mRNA Splicing	41
Detecting and Rescuing Stalled Ribosomes	40
Post-translational modifications on RNA-binding proteins: accelerators, brakes, or passengers in neurodegeneration?	40
Canary in a coal mine: collided ribosomes as sensors of cellular conditions	40
Divalent Cations: A Molecular Glue for Protein Materials	40
The Evolution of STING Signaling and Its Involvement in Cancer	39
Emerging Roles of tRNAs in RNA Virus Infections	38

Spirits in the Material World: Enhancer RNAs in Transcriptional Regulation	38
The Integrator Complex in Transcription and Development	38
Integrins Control Vesicular Trafficking; New Tricks for Old Dogs	38
The Dual Roles of Clusterin in Extracellular and Intracellular Proteostasis	37
Structural basis of torque generation in the bi-directional bacterial flagellar motor	37
Mitochondrial compartmentalization: emerging themes in structure and function	36
Therapeutic targeting of TEAD transcription factors in cancer	35
Gene-Specific Actions of Transcriptional Coregulators Facilitate Physiological Plasticity: Evidence for a Physiological Coregulator Code	35
Mimicry of Short Linear Motifs by Bacterial Pathogens: A Drugging Opportunity	35
Charting a DNA Repair Roadmap for Immunoglobulin Class Switch Recombination	35
Nucleic Acid-Based Technologies Targeting Coronaviruses	34
Big-Data Glycomics: Tools to Connect Glycan Biosynthesis to Extracellular Communication	34
Unfolded Protein Response (UPR) Controls Major Senescence Hallmarks	34
Control of chloroplast degradation and cell death in response to stress	34
Global Approaches in Studying RNA-Binding Protein Interaction Networks	33
How Hierarchical Interactions Make Membraneless Organelles Tick Like Clockwork	33
Art and Science of the Cellular Mesoscale	33
A roadmap for rRNA folding and assembly during transcription	33
Re-Evaluating the Conventional Wisdom about Binding Assays	33
Complementarity of Hydrogen/Deuterium Exchange Mass Spectrometry and Cryo-Electron Microscopy	32
The Mediator kinase module: an interface between cell signaling and transcription	32
Circular RNAs in physiology and non-immunological diseases	32
Time to target the circadian clock for drug discovery	31
Galvanization of Protein–Protein Interactions in a Dynamic Zinc Interactome	31
Mentoring during Uncertain Times	31
Methods to Study Phase-Separated Condensates and the Underlying Molecular Interactions	30
Structural basis of GPCR coupling to distinct signal transducers: implications for biased signaling	30
Plant biochemistry influences tropospheric ozone formation, destruction, deposition, and response	30
Advances in the World of Bacterial Microcompartments	28
Emerging Features of Linear Motif-Binding Hub Proteins	28
Coenzyme Q biochemistry and biosynthesis	28
Cytoskeleton Architecture Regulates Glycolysis Coupling Cellular Metabolism to Mechanical Cues	28
MicroRNA turnover: a tale of tailing, trimming, and targets	27
The many faces of RNA-based RNase P, an RNA-world relic	27
The Autophagy–RNA Interplay: Degradation and Beyond	27
Limiting the DNA Double-Strand Break Resectosome for Genome Protection	27
N6-Methyladenosine Regulates Host Responses to Viral Infection	26
Novel machine learning approaches revolutionize protein knowledge	26
The Life Cycle of the Mu-Opioid Receptor	26
Who let the DoGs out? – biogenesis of stress-induced readthrough transcripts	26
How integrin phosphorylations regulate cell adhesion and signaling	26
Transforming eukaryotic cell culture with macromolecular crowding	25
Completing the canvas: advances and challenges for DNA-PAINT super-resolution imaging	25
Molecular Mechanisms of Lysosome and Nucleus Communication	25
The broader sense of nonsense	25
Proteasome substrate receptors and their therapeutic potential	25
Interaction modules that impart specificity to disordered protein	25
PI3K functions as a hub in mechanotransduction	25
COVID-19 Vaccines Based on Adenovirus Vectors	24
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	24
Coupling lipid synthesis with nuclear envelope remodeling	24
Ribosomal DNA and the nucleolus at the heart of aging	24
Uncovering viral RNA–host cell interactions on a proteome-wide scale	23
A Tale of Two Moieties: Rapidly Evolving CRISPR/Cas-Based Genome Editing	23
Detecting Protein–Small Molecule Interactions Using Limited Proteolysis–Mass Spectrometry (LiP-MS)	23
Nucleosomes Meet Their Remodeler Match	22
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	22
Non-enzymatic Covalent Modifications as a New Chapter in the Histone Code	22
Shedding Light on the Ghost Proteome	21
Cooperative assembly of the mitochondrial respiratory chain	21
Integrating adipocyte insulin signaling and metabolism in the multi-omics era	21
Are Parallel Proliferation Pathways Redundant?	21
Creating memories: molecular mechanisms of CRISPR adaptation	21
Molecular Dynamics Simulations of Ion Channels	20
DNA Processing in the Context of Noncoding Transcription	20
To Ub or not to Ub: a regulatory question in TGF-β signaling	19
Targeting the nucleolus as a therapeutic strategy in human disease	19
On the Cutting Edge: Regulation and Therapeutic Potential of the mRNA 3′ End Nuclease	18
SLC16 Family: From Atomic Structure to Human Disease	17
Balancing the Opposing Principles That Govern Peroxisome Homeostasis	17
Next-Generation Pathology by Multiplexed Immunohistochemistry	17