OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 15. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Advisory Board and Contents	370
Decoding ceramide function: how localization shapes cellular fate and how to study it	206
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	182
From lead to market: chemical approaches to transform peptides into therapeutics	171
Did circular DNA shape the evolution of mammalian genomes?	108
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	107
Understanding peptide hormones: from precursor proteins to bioactive molecules	104
Adding post-translational modifications and protein–protein interactions to protein schematics	102
Multiplayer virtual reality for understanding biomolecular structures	97
Subscription and Copyright Information	97
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	89
Subscription and Copyright Information	86
Subscription and Copyright Information	85
Exploiting enzyme evolution for computational protein design	82
Harnessing the power of peptides: advances and collaborations in biochemistry	81
Advisory Board and Contents	81
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	79
Conserved signaling gears that sustain circadian clock robustness	75
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	74
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	68
Molecular mechanisms of heat shock factor 1 regulation	67
Cellular oxidants and the proteostasis network: balance between activation and destruction	67
Novel machine learning approaches revolutionize protein knowledge	64
Subconductance states add complexity to Piezo1 gating model	63
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	63

Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	62
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	61
Glucokinase: from allosteric glucose sensing to disease variants	60
Microtubule nucleation for spindle assembly: one molecule at a time	59
Structural parasitology of the malaria parasite Plasmodium falciparum	59
Using graphs and charts in scientific figures	57
The transition phase: preparing to launch a laboratory	57
Transcription-coupled global genomic repair in E. coli	56
Diverse heterochromatin states restricting cell identity and reprogramming	53
Mitochondrial dynamics and pore formation in regulated cell death pathways	51
Activation, decommissioning, and dememorization: enhancers in a life cycle	50
Transcription-coupled nucleosome assembly	50
Determining and interpreting protein lifetimes in mammalian tissues	49
Proteasome-derived peptides: separating the trash from the recycling	49
Creative approaches using proximity labeling to gain new biological insights	48
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	48
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	48
Exploring membrane asymmetry and its effects on membrane proteins	45
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	45
Subscription and Copyright Information	45
Two hearts beat as one: the debate over RAS dimers continues	42
Functional modulation of chemical mediators in microbial communities	42
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	42
The expanding landscape of canonical and non-canonical protein phosphorylation	41
Engineering RiPP pathways: strategies for generating complex bioactive peptides	41
An outreach activity to enhance biochemistry pedagogy	41
The RNA tether model for human chromosomal translocation fragile zones	41
A plant immune protein fights against cancer	41
Thiol dioxygenases: from structures to functions	41
Apart, together	41
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	39
Making nucleic acid structures and schematics	39
Control of chloroplast degradation and cell death in response to stress	38
Advisory Board and Contents	37
Making ends meet: a universal driver of large ribosomal subunit biogenesis	37
Seeing the forest through the trees: characterizing the glycoproteome	36
Just bypass it: mechanisms of DNA damage tolerance	36
The metabolic code of ferroptosis: nutritional regulators of cell death	36
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	34
Innovations in the electron transport chain fuel archaeal methane metabolism	34
Mitochondrial compartmentalization: emerging themes in structure and function	34
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	33
Subscription and Copyright Information	32
Cloud computing platforms to support cryo-EM structure determination	32
Subscription and Copyright Information	31
Liquid–liquid phase separation in presynaptic nerve terminals	30
Metamorphic protein folding as evolutionary adaptation	30
Non-histone binding functions of PHD fingers	30
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	30
Zn2+ transients and signaling in mammalian systems	30

Advisory Board and Contents	29
Convergent evolution in two bacterial replicative helicase loaders	29
Advisory Board and Contents	29
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	29
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
Time-resolved serial crystallography to reveal protein structural changes	28
Multifaceted control of T cell differentiation by STIM1	28
Orange carotenoid proteins: structural understanding of evolution and function	28
Circular RNAs in physiology and non-immunological diseases	27
Proteostasis in cellular dormancy: lessons from yeast to oocytes	27
Recent advances in enzymes active on lignin-derived aromatic compounds	27
CryoEM shows the active dynein complex on microtubules	26
Programmable protein editing	26
Cooperative assembly of the mitochondrial respiratory chain	26
The crosstalk of m6A-modified RNA with DNA damage repair	26
Forging a path toward a more sustainable laboratory	26
Does chromatin function as a metabolite reservoir?	26
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	25
Monitoring subcellular NADP redox state with NAPstar biosensors	25
Subscription and Copyright Information	25
E3 ubiquitin ligases in signaling, disease, and therapeutics	24
Advancing nanopore technology toward protein identification and sequencing	24
TRAPs: the ‘elevator-with-an-operator’ mechanism	24
Computationally guided AAV engineering for enhanced gene delivery	24
Lysines and cysteines: partners in stress?	24
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	23
Advances, challenges, and opportunities in structural biology	23
FN3K: the (un)sweetest kinase	23
Discovering riboswitches: the past and the future	23
Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	23
To Ub or not to Ub: a regulatory question in TGF-β signaling	22
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	22
SRC homology 3 domains: multifaceted binding modules	22
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	22
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	21
Subscription and Copyright Information	21
Wrapping up a special series on scientific figure development	21
Synaptoneurolipidomics: lipidomics in the study of synaptic function	20
Endogenous plant nitroxyl, a new component of nitric oxide biology	20
How integrin phosphorylations regulate cell adhesion and signaling	20
Discordant skeletal muscle gene and protein responses to exercise	20
How to compile different types of structural visualizations in one panel	20
Oxytocin and vasopressin signaling in health and disease	19
Advisory Board and Contents	19
Protein SUMOylation and phase separation: partners in stress?	19
Enlightening epigenetics: optochemical tools illuminate the path	18
Maximizing grant funding: strategies for negotiating laboratory pricing	18
Spray-type modifications: an emerging paradigm in post-translational modifications	18
Structural transitions modulate the chaperone activities of Grp94	18
Uncovering viral RNA–host cell interactions on a proteome-wide scale	18
Cytoplasmic gene expression: lessons from poxviruses	18
Creating accessibility in academic negotiations	18
Subscription and Copyright Information	18
Understanding the dynamic design of the spliceosome	17
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	17
Subscription and Copyright Information	17
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	17
Subscription and Copyright Information	17
Exploring nondegrading molecular glues for protein–protein interactions	17
Protein Termini 2022: central roles of protein ends	17
Biomolecules capturing live bacteria from clinical samples	17
Advisory Board and Contents	17
Substrate and phosphorylation site selection by phosphoprotein phosphatases	16
News about amino acid metabolism in plant–microbe interactions	16
A vigilant gliding bird protects plants	16
Film-like organelles equip cells with multiple genetic codes	16
Advisory Board and Contents	16
Using light to drive energy transduction in metazoan aging	16
Advisory Board and Contents	16
Thermal proteome profiling of protein-centric interactions and modifications	15
Ancestral ribonucleases back in motion for evolutionary-dynamics guided protein design	15
The intersection of viral mimicry and nuclear entry	15
The lysosome as a master regulator of iron metabolism	15
Mitochondria in disease: changes in shapes and dynamics	15
From transcription to export: mRNA’s winding path to the cytoplasm	15
Coupling lipid synthesis with nuclear envelope remodeling	15
Structural advances in sterol-sensing domain-containing proteins	15
Histone-mediated chromatin organization in prokaryotes and viruses	15
Subscription and Copyright Information	15