OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Subscription and Copyright Information	281
Subscription and Copyright Information	228
Subscription and Copyright Information	164
Adding post-translational modifications and protein–protein interactions to protein schematics	148
Advisory Board and Contents	144
Multiplayer virtual reality for understanding biomolecular structures	142
Advisory Board and Contents	139
Transporter Specificity: A Tale of Loosened Elevator-Sliding	137
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	126
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	115
Harnessing the power of peptides: advances and collaborations in biochemistry	107
From lead to market: chemical approaches to transform peptides into therapeutics	97
Did circular DNA shape the evolution of mammalian genomes?	96
Cellular oxidants and the proteostasis network: balance between activation and destruction	94
Novel machine learning approaches revolutionize protein knowledge	93
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	91
Decoding ceramide function: how localization shapes cellular fate and how to study it	90
The CYTOLD and ERTOLD pathways for lipid droplet–protein targeting	87
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	87
Molecular mechanisms of heat shock factor 1 regulation	86
Understanding peptide hormones: from precursor proteins to bioactive molecules	84
Exploiting enzyme evolution for computational protein design	82
Subscription and Copyright Information	78
Transcription-coupled global genomic repair in E. coli	77
Diverse heterochromatin states restricting cell identity and reprogramming	75

Subconductance states add complexity to Piezo1 gating model	75
Using graphs and charts in scientific figures	70
The transition phase: preparing to launch a laboratory	70
Structural parasitology of the malaria parasite Plasmodium falciparum	70
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	69
Determining and interpreting protein lifetimes in mammalian tissues	68
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	67
Microtubule nucleation for spindle assembly: one molecule at a time	66
Exploring membrane asymmetry and its effects on membrane proteins	66
Transcription-coupled nucleosome assembly	64
Cell entry by SARS-CoV-2	61
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	58
Glucokinase: from allosteric glucose sensing to disease variants	56
FUS and TDP-43 Phases in Health and Disease	56
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	56
Creative approaches using proximity labeling to gain new biological insights	55
Activation, decommissioning, and dememorization: enhancers in a life cycle	54
Apart, together	54
Seeing the forest through the trees: characterizing the glycoproteome	51
Advisory Board and Contents	51
The expanding landscape of canonical and non-canonical protein phosphorylation	51
Subscription and Copyright Information	49
Innovations in the electron transport chain fuel archaeal methane metabolism	48
Making nucleic acid structures and schematics	46
Two hearts beat as one: the debate over RAS dimers continues	46
Engineering RiPP pathways: strategies for generating complex bioactive peptides	46
The RNA tether model for human chromosomal translocation fragile zones	46
An outreach activity to enhance biochemistry pedagogy	45
Making ends meet: a universal driver of large ribosomal subunit biogenesis	44
Protein structure and aggregation: a marriage of necessity ruled by aggregation gatekeepers	44
Thiol dioxygenases: from structures to functions	44
Direct Structural Insights into GABAA Receptor Pharmacology	42
A plant immune protein fights against cancer	42
Control of chloroplast degradation and cell death in response to stress	42
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	41
Functional modulation of chemical mediators in microbial communities	41
Mitochondrial compartmentalization: emerging themes in structure and function	41
The metabolic code of ferroptosis: nutritional regulators of cell death	40
Subscription and Copyright Information	39
Subscription and Copyright Information	39
Non-histone binding functions of PHD fingers	39
Cloud computing platforms to support cryo-EM structure determination	37
Convergent evolution in two bacterial replicative helicase loaders	36
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	36
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	35
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	35
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	35
Metamorphic protein folding as evolutionary adaptation	35
Liquid–liquid phase separation in presynaptic nerve terminals	33
Origins and evolving functionalities of tRNA-derived small RNAs	33

Advisory Board and Contents	32
Time-resolved serial crystallography to reveal protein structural changes	32
Subscription and Copyright Information	32
CryoEM shows the active dynein complex on microtubules	30
Advisory Board and Contents	30
Recent advances in enzymes active on lignin-derived aromatic compounds	29
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
Forging a path toward a more sustainable laboratory	28
Does chromatin function as a metabolite reservoir?	27
Circular RNAs in physiology and non-immunological diseases	27
Orange carotenoid proteins: structural understanding of evolution and function	26
Advances, challenges, and opportunities in structural biology	26
Cooperative assembly of the mitochondrial respiratory chain	26
Lamin post-translational modifications: emerging toggles of nuclear organization and function	26
Multifaceted control of T cell differentiation by STIM1	26
Lysines and cysteines: partners in stress?	25
Computationally guided AAV engineering for enhanced gene delivery	25
Monitoring subcellular NADP redox state with NAPstar biosensors	25
Hallmarks of icosahedral virus capsids emerged during laboratory evolution of a bacterial enzyme	25
TRAPs: the ‘elevator-with-an-operator’ mechanism	25
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	25
Subscription and Copyright Information	24
Wrapping up a special series on scientific figure development	24
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	23
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	23
How to compile different types of structural visualizations in one panel	23
Lipidation status of single membrane-associated ATG8 proteins	23
How integrin phosphorylations regulate cell adhesion and signaling	23
FN3K: the (un)sweetest kinase	23
Endogenous plant nitroxyl, a new component of nitric oxide biology	22
Oxytocin and vasopressin signaling in health and disease	21
Synaptoneurolipidomics: lipidomics in the study of synaptic function	21
To Ub or not to Ub: a regulatory question in TGF-β signaling	21
Discordant skeletal muscle gene and protein responses to exercise	21
Subscription and Copyright Information	21
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	21
Discovering riboswitches: the past and the future	21
Advisory Board and Contents	21
Protein SUMOylation and phase separation: partners in stress?	21
SRC homology 3 domains: multifaceted binding modules	21
Mitochondrial DNA: cellular genotoxic stress sentinel	20
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	20
Maximizing grant funding: strategies for negotiating laboratory pricing	20
Spray-type modifications: an emerging paradigm in post-translational modifications	20
Understanding the dynamic design of the spliceosome	20
Protein Termini 2022: central roles of protein ends	20
Cytoplasmic gene expression: lessons from poxviruses	20
Regulation of Autophagy Enzymes by Nutrient Signaling	20
Creating accessibility in academic negotiations	20
Structural transitions modulate the chaperone activities of Grp94	20
Enlightening epigenetics: optochemical tools illuminate the path	20
Biomolecules capturing live bacteria from clinical samples	19
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	18
Subscription and Copyright Information	18
More Than Just Closed and Open: Unraveling a Mechanosensor	18
Uncovering viral RNA–host cell interactions on a proteome-wide scale	18
Advisory Board and Contents	18
Using light to drive energy transduction in metazoan aging	17
Advisory Board and Contents	17
Film-like organelles equip cells with multiple genetic codes	17
Structural advances in sterol-sensing domain-containing proteins	17
Advisory Board and Contents	17
Coupling lipid synthesis with nuclear envelope remodeling	17
Subscription and Copyright Information	17
A vigilant gliding bird protects plants	17
Take Your PIC	17
Transforming eukaryotic cell culture with macromolecular crowding	16
Advisory Board and Contents	16
Substrate and phosphorylation site selection by phosphoprotein phosphatases	16
News about amino acid metabolism in plant–microbe interactions	16
Mitochondria in disease: changes in shapes and dynamics	16
Thermal proteome profiling of protein-centric interactions and modifications	16
The lysosome as a master regulator of iron metabolism	16