OOIR: Observatory of International Research

Papers

(The TQCC of Trends in Biochemical Sciences is 16. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Advisory Board and Contents	492
Subscription and Copyright Information	243
System reset: topoisomerase 1 clears mitotic DNA for transcriptional memory	213
Subscription and Copyright Information	136
Conserved signaling gears that sustain circadian clock robustness	133
Advisory Board and Contents	132
Harnessing the power of peptides: advances and collaborations in biochemistry	131
Fragment-based drug discovery supports drugging ‘undruggable’ protein–protein interactions	127
Understanding peptide hormones: from precursor proteins to bioactive molecules	115
Exploiting enzyme evolution for computational protein design	110
Adding post-translational modifications and protein–protein interactions to protein schematics	106
Cellular oxidants and the proteostasis network: balance between activation and destruction	102
CRISPR/Cas9 boosts wheat yield by reducing brassinosteroid signaling	102
Did circular DNA shape the evolution of mammalian genomes?	93
Novel machine learning approaches revolutionize protein knowledge	85
Engineered protein inhibitors for precise targeting of matrix metalloproteinases	80
Parallels and crosstalk of ADP-ribosylation and ubiquitination	77
Decoding ceramide function: how localization shapes cellular fate and how to study it	75
Intrinsic and extrinsic regulators of Aux/IAA protein degradation dynamics	71
Multiplayer virtual reality for understanding biomolecular structures	69
From lead to market: chemical approaches to transform peptides into therapeutics	69
Subconductance states add complexity to Piezo1 gating model	67
Microtubule nucleation for spindle assembly: one molecule at a time	66
Creative approaches using proximity labeling to gain new biological insights	65
Mobile peptide and receptor complex mediates systemic stomatal immunity	64

Mitochondrial dynamics and pore formation in regulated cell death pathways	62
Cotranslational sorting and processing of newly synthesized proteins in eukaryotes	61
Transcription-coupled nucleosome assembly	59
Exploring membrane asymmetry and its effects on membrane proteins	59
Autophagy regulation by phase separation, avidity, and wetting	58
Proteasome-derived peptides: separating the trash from the recycling	56
Bacterial transformation	55
Using graphs and charts in scientific figures	54
The transition phase: preparing to launch a laboratory	54
Transcription factor IID parks and drives preinitiation complexes at sharp or broad promoters	53
Determining and interpreting protein lifetimes in mammalian tissues	53
Structural diversity of the CE-clan proteases in bacteria to disarm host ubiquitin defenses	52
Activation, decommissioning, and dememorization: enhancers in a life cycle	50
Small RNA and Toll-like receptor interactions: origins and disease mechanisms	50
Challenges of biomolecular science education in Africa and the way forward	49
Transcription-coupled global genomic repair in E. coli	49
Diverse heterochromatin states restricting cell identity and reprogramming	48
Glucokinase: from allosteric glucose sensing to disease variants	48
The HIF axes in cancer: angiogenesis, metabolism, and immune-modulation	44
Subscription and Copyright Information	43
Mitochondrial tRNA processing: a neutral evolutionary ratchet innovation	43
Two hearts beat as one: the debate over RAS dimers continues	43
Making nucleic acid structures and schematics	42
A plant immune protein fights against cancer	42
Advisory Board and Contents	42
An outreach activity to enhance biochemistry pedagogy	42
Seeing the forest through the trees: characterizing the glycoproteome	41
The RNA tether model for human chromosomal translocation fragile zones	40
Thiol dioxygenases: from structures to functions	40
Structural insights into membrane adenylyl cyclases, initiators of cAMP signaling	39
Just bypass it: mechanisms of DNA damage tolerance	37
Making ends meet: a universal driver of large ribosomal subunit biogenesis	37
Engineering RiPP pathways: strategies for generating complex bioactive peptides	36
The metabolic code of ferroptosis: nutritional regulators of cell death	36
Innovations in the electron transport chain fuel archaeal methane metabolism	35
Pyruvylation: a link bridging metabolic disorders and impaired antiviral immunity	35
Adenosine signals an imbalance between activity and supply in privileged cells	34
Control of chloroplast degradation and cell death in response to stress	34
Tandem repeats matter for the functional versatility of giant proteins	34
The expanding landscape of canonical and non-canonical protein phosphorylation	33
Balancing act: lipid-to-protein ratios steer the aggregation fate of α-synuclein	33
Zn2+ transients and signaling in mammalian systems	33
Functional modulation of chemical mediators in microbial communities	33
Convergent evolution in two bacterial replicative helicase loaders	33
Non-histone binding functions of PHD fingers	32
Metamorphic protein folding as evolutionary adaptation	32
Subscription and Copyright Information	32
Subscription and Copyright Information	32
Molecular regulation of the salicylic acid hormone pathway in plants under changing environmental conditions	32
Subscription and Copyright Information	32

Subscription and Copyright Information	32
Rethinking transcription factor dynamics and transcription regulation in eukaryotes	32
Decoding disease-relevant variants with base and prime editors at scale	31
Advisory Board and Contents	30
Double-duty isomerases: a case study of isomerization-coupled enzymatic catalysis	30
Does chromatin function as a metabolite reservoir?	30
Advisory Board and Contents	30
Programmable protein editing	30
Liquid–liquid phase separation in presynaptic nerve terminals	30
Time-resolved serial crystallography to reveal protein structural changes	29
CryoEM shows the active dynein complex on microtubules	28
The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine	28
Forging a path toward a more sustainable laboratory	28
TiBS at 50	28
Journey to the past: molecular de-extinction enables the discovery of ancient β-defensins and highlights their evolutionary history	28
Proteostasis in cellular dormancy: lessons from yeast to oocytes	27
The crosstalk of m6A-modified RNA with DNA damage repair	27
Orange carotenoid proteins: structural understanding of evolution and function	27
Recent advances in enzymes active on lignin-derived aromatic compounds	26
Cooperative assembly of the mitochondrial respiratory chain	26
Multifaceted control of T cell differentiation by STIM1	25
Subscription and Copyright Information	25
Functional insights into the nitrogenase-like enzyme superfamily	25
Advisory Board and Contents	24
Computationally guided AAV engineering for enhanced gene delivery	24
Monitoring subcellular NADP redox state with NAPstar biosensors	24
Lysines and cysteines: partners in stress?	24
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis	23
TRAPs: the ‘elevator-with-an-operator’ mechanism	23
Advances, challenges, and opportunities in structural biology	23
E3 ubiquitin ligases in signaling, disease, and therapeutics	23
Advancing nanopore technology toward protein identification and sequencing	23
Powerful polymerases synthesize labeled RNA better, faster, stronger	23
Advisory Board and Contents	22
Subscription and Copyright Information	22
SLiM-binding pockets: an attractive target for broad-spectrum antivirals	22
Decoding anaphylatoxins: unveiling the molecular mechanisms of complement receptor activation and signaling	22
Advances in understanding aryl hydrocarbon receptor structure, function, and modulation	22
FN3K: the (un)sweetest kinase	22
Oxytocin and vasopressin signaling in health and disease	21
Endogenous plant nitroxyl, a new component of nitric oxide biology	21
Synaptoneurolipidomics: lipidomics in the study of synaptic function	21
Protein SUMOylation and phase separation: partners in stress?	21
Wrapping up a special series on scientific figure development	21
Discovering riboswitches: the past and the future	21
How to compile different types of structural visualizations in one panel	21
SRC homology 3 domains: multifaceted binding modules	20
PTMs as molecular encoders: reprogramming chaperones into epichaperomes for network control in disease	20
Discordant skeletal muscle gene and protein responses to exercise	20
To Ub or not to Ub: a regulatory question in TGF-β signaling	20
Ligand-independent receptor clustering modulates transmembrane signaling: a new paradigm	20
Advisory Board and Contents	20
The CENP-A nucleosome: where and when it happens during the inner kinetochore’s assembly	19
Enlightening epigenetics: optochemical tools illuminate the path	19
Subscription and Copyright Information	19
Regulation of plant NLRs by post-translational modifications	19
Maximizing grant funding: strategies for negotiating laboratory pricing	19
Creating accessibility in academic negotiations	19
Spray-type modifications: an emerging paradigm in post-translational modifications	19
Emerging structural insights into PRC2 function in development and disease	19
Exploring nondegrading molecular glues for protein–protein interactions	18
Understanding the dynamic design of the spliceosome	18
Protein Termini 2022: central roles of protein ends	18
Structural transitions modulate the chaperone activities of Grp94	18
The past, present, and future of RNA biochemistry and mitochondrial research	18
Biomolecules capturing live bacteria from clinical samples	18
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum	18
Cytoplasmic gene expression: lessons from poxviruses	18
Advisory Board and Contents	17
Subscription and Copyright Information	17
Subscription and Copyright Information	17
Thermal proteome profiling of protein-centric interactions and modifications	16
A vigilant gliding bird protects plants	16
Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease	16
Film-like organelles equip cells with multiple genetic codes	16
Integrated approaches for discovery and functional annotation of proteins of unknown function	16
Substrate and phosphorylation site selection by phosphoprotein phosphatases	16
Advisory Board and Contents	16
Adenosylhomocysteinase–adenosine complex links m6A and cancer lipid metabolism	16