Bioorganic & Medicinal Chemistry

Article	Citations
A comprehensive review on the biological interest of quinoline and its derivatives	238
Protease targeted COVID-19 drug discovery and its challenges: Insight into viral main protease (Mpro) and papain-like protease (PLpro) inhibitors	114
Tetrazoles as anticancer agents: A review on synthetic strategies, mechanism of action and SAR studies	72
Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells	66
An insight into the medicinal attributes of berberine derivatives: A review	65
Application of marine natural products in drug research	64
Design, synthesis, and anti-proliferative evaluation of new quinazolin-4(3H)-ones as potential VEGFR-2 inhibitors	58
Structural modification aimed for improving solubility of lead compounds in early phase drug discovery	53
From triazolophthalazines to triazoloquinazolines: A bioisosterism-guided approach toward the identification of novel PCAF inhibitors with potential anticancer activity	52
Pyridine alkaloids with activity in the central nervous system	50
Recent advances on synthesis and biological activities of aurones	50
Antiviral strategies targeting host factors and mechanisms obliging +ssRNA viral pathogens	49
Chemical reactivity and uses of 1-phenyl-3-methyl-5-pyrazolone (PMP), also known as edaravone	48
[1,2,4]Triazolo[4,3-c]quinazoline and bis([1,2,4]triazolo)[4,3-a:4′,3′-c]quinazoline derived DNA intercalators: Design, synthesis, in silico ADMET profile, molecular docking and anti-proliferative eva	47
The research progress in and perspective of potential fungicides: Succinate dehydrogenase inhibitors	45
Exploration of 1,2,3-triazole linked benzenesulfonamide derivatives as isoform selective inhibitors of human carbonic anhydrase	44
Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1,2,4-triazole derivatives their molecular docking and kinetic studies	43
Indole acrylonitriles as potential anti-hyperglycemic agents: Synthesis, α-glucosidase inhibitory activity and molecular docking studies	41
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors	40
Porphyrin and phthalocyanine photosensitizers designed for targeted photodynamic therapy of colorectal cancer	40
The natural-based optimization of kojic acid conjugated to different thio-quinazolinones as potential anti-melanogenesis agents with tyrosinase inhibitory activity	39
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer’s disease	37
Covalent peptides and proteins for therapeutics	37
Identification of the first noncompetitive SARM1 inhibitors	34
Design, synthesis and molecular docking studies of thymol based 1,2,3-triazole hybrids as thymidylate synthase inhibitors and apoptosis inducers against breast cancer cells	34

Synthetic and therapeutic perspectives of nitrogen containing heterocycles as anti-convulsants	33
Computer-aided design of 1,4-naphthoquinone-based inhibitors targeting cruzain and rhodesain cysteine proteases	33
Cytotoxicity of 4-substituted quinoline derivatives: Anticancer and antileishmanial potential	32
Bioorthogonal strategies for the in vivo synthesis or release of drugs	30
Boron-Containing heterocycles as promising pharmacological agents	30
Design, synthesis & biological evaluation of ferulic acid-based small molecule inhibitors against tumor-associated carbonic anhydrase IX	30
The advantages of describing covalent inhibitor in vitro potencies by IC50 at a fixed time point. IC50 determination of covalent inhibitors provides meaningful data to medicinal chemistry for SAR opti	29
Antimicrobial and cytotoxic effects of ammonium derivatives of diterpenoids steviol and isosteviol	29
Design and synthesis of novel (S)-Naproxen hydrazide-hydrazones as potent VEGFR-2 inhibitors and their evaluation in vitro/in vivo breast cancer models	29
Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights	28
Recent progress in covalent warheads for in vivo targeting of endogenous proteins	28
Novel thiobarbiturates as potent urease inhibitors with potential antibacterial activity: Design, synthesis, radiolabeling and biodistribution study	27
Glycyrrhetinic acid derivatives as Zika virus inhibitors: Synthesis and antiviral activity in vitro	27
Boronic acid-based arginase inhibitors in cancer immunotherapy	26
Endocytosis in cellular uptake of drug delivery vectors: Molecular aspects in drug development	26
MCC950, a NLRP3 inhibitor, ameliorates lipopolysaccharide-induced lung inflammation in mice	26
SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases	26
Assays for the identification and quantification of sialic acids: Challenges, opportunities and future perspectives	25
Discovery of novel 1,3,5-triazine derivatives as potent inhibitor of cervical cancer via dual inhibition of PI3K/mTOR	25
Azaindole therapeutic agents	24
Rational design, synthesis and biological evaluation of novel multitargeting anti-AD iron chelators with potent MAO-B inhibitory and antioxidant activity	24
Thiacalixarene based quaternary ammonium salts as promising antibacterial agents	24
Streptochlorin analogues as potential antifungal agents: Design, synthesis, antifungal activity and molecular docking study	23
Synthesis of osthol-based botanical fungicides and their antifungal application in crop protection	23
Potential inhibitors interacting in Neuropilin-1 to develop an adjuvant drug against COVID-19, by molecular docking	23
Identification of new [1,2,4]triazolo[4,3-a]quinoxalines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, anticancer evaluation, and in silico studies	23
Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential	23
Design, synthesis biological activity, and docking of novel fluopyram derivatives containing guanidine group	23
Novel 4-(piperazin-1-yl)quinolin-2(1H)-one bearing thiazoles with antiproliferative activity through VEGFR-2-TK inhibition	23
Synthesis of novel dual target inhibitors of PARP and HSP90 and their antitumor activities	23
Design, synthesis and biological evaluation of novel chalcone-like compounds as potent and reversible pancreatic lipase inhibitors	22
Potency and pharmacokinetics of GS-441524 derivatives against SARS-CoV-2	22
From natural products to HDAC inhibitors: An overview of drug discovery and design strategy	22
Dismantling the bacterial glycocalyx: Chemical tools to probe, perturb, and image bacterial glycans	21
Progress in the development of small molecular inhibitors of the Bruton’s tyrosine kinase (BTK) as a promising cancer therapy	21
Examination of multiple Trypanosoma cruzi targets in a new drug discovery approach for Chagas disease	21
Synthesis and anticancer activity of new coumarin-3-carboxylic acid derivatives as potential lactate transport inhibitors	21
Structure-based designing and synthesis of 2-phenylchromone derivatives as potent tyrosinase inhibitors: In vitro and in silico studies	21
Discovery, development, chemical diversity and design of isoxazoline-based insecticides	21
Recent insight into the biological activities and SAR of quinolone derivatives as multifunctional scaffold	21
Evaluation of imidazo[2,1–b]thiazole-based anticancer agents in one decade (2011–2020): Current status and future prospects	21
New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation	21
Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors	21
Natural spirocyclic alkaloids and polyphenols as multi target dementia leads	21
Using in vitro ADME data for lead compound selection: An emphasis on PAMPA pH 5 permeability and oral bioavailability	20
CYPlebrity: Machine learning models for the prediction of inhibitors of cytochrome P450 enzymes	20
Large screening of DNA-compatible reaction conditions for Suzuki and Sonogashira cross-coupling reactions and for reverse amide bond formation	20
New BODIPYs for photodynamic therapy (PDT): Synthesis and activity on human cancer cell lines	20
COVID-19 therapy: What weapons do we bring into battle?	20
Multicomponent reactions in crop protection chemistry	20

Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer’s disease	19
Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2	19
Indole derivatives as tubulin polymerization inhibitors for the development of promising anticancer agents	19
Expedient discovery for novel antifungal leads: 1,3,4-Oxadiazole derivatives bearing a quinazolin-4(3H)-one fragment	19
Glutathione peroxidase-like functions of 1,2-diselenane-4,5-diol and its amphiphilic derivatives: Switchable catalytic cycles depending on peroxide substrates	18
Galangin ameliorated pulmonary fibrosis in vivo and in vitro by regulating epithelial-mesenchymal transition	18
Design concepts for DNA-encoded library synthesis	18
On the design of lead-like DNA-encoded chemical libraries	18
Discovery of potent glycogen synthase kinase 3/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer’s disease	18
Design, synthesis and anti-inflammatory activity of imidazol-5-yl pyridine derivatives as p38α/MAPK14 inhibitor	18
Xanthones for melanogenesis inhibition: Molecular docking and QSAR studies to understand their anti-tyrosinase activity	18
Synthesis, cytotoxicity, and in vivo antitumor activity study of parthenolide semicarbazones and thiosemicarbazones	18
Druggable targets from coronaviruses for designing new antiviral drugs	18
Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents	18
New CDK8 inhibitors as potential anti-leukemic agents – Design, synthesis and biological evaluation	18
A brief overview on recent advances in spiro[chromane-2,4′-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research	18
Translation of the copper/bipyridine-promoted Petasis reaction to solid phase-coupled DNA for encoded library synthesis	18
In vitro and in vivo evaluation of 211At-labeled fibroblast activation protein inhibitor for glioma treatment	18
Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro	18
Discovery of soluble epoxide hydrolase inhibitors through DNA-encoded library technology (ELT)	18
Preparation and evaluation of soluble epoxide hydrolase inhibitors with improved physical properties and potencies for treating diabetic neuropathic pain	18
Mitochondria-localizing curcumin-cryptolepine Zn(II) complexes and their antitumor activity	18
Anti-inflammatory effect and inhibition of nitric oxide production by targeting COXs and iNOS enzymes with the 1,2-diphenylbenzimidazole pharmacophore	18
Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS-induced acute lung injury (ALI)	18
A network pharmacology-integrated metabolomics strategy for clarifying the action mechanisms of Schisandrae Chinensis Fructus for treating drug-induced liver injury by acetaminophen	17
Genetic code expansion in mammalian cells: A plasmid system comparison	17
Sophorolipids: Anti-cancer activities and mechanisms	17
The splicing modulator sulfonamide indisulam reduces AR-V7 in prostate cancer cells	17
Synthesis and bioevaluation of N-(3,4,5-trimethoxyphenyl)-1H-pyrazolo[3,4-b]pyridin-3-amines as tubulin polymerization inhibitors with anti-angiogenic effects	17
Predictive models for estimating cytotoxicity on the basis of chemical structures	17
Kinetic and structural investigations of novel inhibitors of human epithelial 15-lipoxygenase-2	17
A review upon medicinal perspective and designing rationale of DPP-4 inhibitors	17
Identification of isoform/domain-selective fragments from the selection of DNA-encoded dynamic library	17
Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry	17
Discovery of a new potent inhibitor of mushroom tyrosinase (Agaricus bisporus) containing 4-(4-hydroxyphenyl)piperazin-1-yl moiety	17
Anti-inflammatory activity of naturally occuring diarylheptanoids – A review	17
In vivo organic synthesis by metal catalysts	17
Recent applications of seven-membered rings in drug design	17
Synthetic 1,4-Naphthoquinones inhibit P2X7 receptors in murine neuroblastoma cells	17
Synthetic approaches to the 2015–2018 new agrochemicals	17
Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors	17
Structure-based design and synthesis of novel furan-diketopiperazine-type derivatives as potent microtubule inhibitors for treating cancer	16
Next generation quorum sensing inhibitors: Accounts on structure activity relationship studies and biological activities	16
Effects of data quality and quantity on deep learning for protein-ligand binding affinity prediction	16
Antiviral fungal metabolites and some insights into their contribution to the current COVID-19 pandemic	16
Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2	16
Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer’s disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation	16
Nitrogen-containing naringenin derivatives for reversing multidrug resistance in cancer	16
Antiviral evaluation of hydroxyethylamine analogs: Inhibitors of SARS-CoV-2 main protease (3CLpro), a virtual screening and simulation approach	16
Biotin and glucose co-modified multi-targeting liposomes for efficient delivery of chemotherapeutics for the treatment of glioma	16
Novel 3-benzylidene/benzylphthalide Mannich base derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease	16
Synthesis and structure-activity relationships for tetrahydroisoquinoline-based inhibitors of Mycobacterium tuberculosis	16
Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement	16
Berberine improves liver injury induced glucose and lipid metabolic disorders via alleviating ER stress of hepatocytes and modulating gut microbiota in mice	16
Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment	16
A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies	16
De novo design with deep generative models based on 3D similarity scoring	15
Polyketides from the marine-derived fungus Aspergillus falconensis: In silico and in vitro cytotoxicity studies	15
Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones	15
Synthesis, anticancer and antimicrobial evaluation of new benzofuran based derivatives: PI3K inhibition, quorum sensing and molecular modeling study	15
Discovery of a polysubstituted phenyl containing novel N-phenylpyrazole scaffold as potent ryanodine receptor activator	15
Synthesis and evaluation of the performance of a small molecule library based on diverse tropane-related scaffolds	15
Synthesis and evaluation of 18F labeled crizotinib derivative [18F]FPC as a novel PET probe for imaging c-MET-positive NSCLC tumor	15
Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis	15
Design, synthesis and evaluation of carbamate-linked uridyl-based inhibitors of human ST6Gal I	15
Novel 2-amino-1,4-naphthoquinone hybrids: Design, synthesis, cytotoxicity evaluation and in silico studies	15
Ancistrobrevidines A-C and related naphthylisoquinoline alkaloids with cytotoxic activities against HeLa and pancreatic cancer cells, from the liana Ancistrocladus abbreviatus	15
Thioether-linked dihydropyrrol-2-one analogues as PqsR antagonists against antibiotic resistant Pseudomonas aeruginosa	15
Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase	15
Amide derivatives of Gallic acid: Design, synthesis and evaluation of inhibitory activities against in vitro α-synuclein aggregation	15
DNA-encoded C H functionality via photoredox-mediated hydrogen atom transformation catalysis	15
Diversity-oriented synthesis as a tool to expand the chemical space of DNA-encoded libraries	15
Developments of small molecules as inhibitors for carbonic anhydrase isoforms	15
Structure-guided optimization of D-captopril for discovery of potent NDM-1 inhibitors	15
Design and synthesis of acrylate and acrylamide substituted pyrimidinediones as potential PPO herbicides	15
Synthesis, state-of-the-art NMR-binding and molecular modeling study of new benzimidazole core derivatives as Pin1 inhibitors: Targeting breast cancer	15
α-Glucosidase inhibitory and nitric oxide production inhibitory activities of alkaloids isolated from a twig extract of Polyalthia cinnamomea	14
Lipoic acid modified antimicrobial peptide with enhanced antimicrobial properties	14
Synthesis and evaluation of enantiomers of hydroxychloroquine against SARS-CoV-2 in vitro	14
Guanidine-based β amyloid precursor protein cleavage enzyme 1 (BACE-1) inhibitors for the Alzheimer's disease (AD): A review	14

6,6′-Aryl trehalose analogs as potential Mincle ligands	14
Synthesis, bioevaluation and docking studies of new imidamide derivatives as nitric oxide synthase inhibitors	14
Inhibition of Mycobacterium tuberculosis InhA: Design, synthesis and evaluation of new di-triclosan derivatives	14
Lactate dehydrogenase and malate dehydrogenase: Potential antiparasitic targets for drug development studies	14
A novel potent metal-binding NDM-1 inhibitor was identified by fragment virtual, SPR and NMR screening	14
Isolation and biological activity of azocine and azocane alkaloids	14
The chemistry and biology of phosphatidylinositol 4-phosphate at the plasma membrane	14
Synthesis and antibiofilm evaluation of 3-hydroxy-2,3-dihydroquinazolin-4(1H)-one derivatives against opportunistic pathogen Acinetobacter baumannii	14
Antileishmanial macrolides from ant-associated Streptomyces sp. ISID311	14
Discovery of thiapyran-pyrimidine derivatives as potential EGFR inhibitors	14
Optimization of linear and cyclic peptide inhibitors of KEAP1-NRF2 protein-protein interaction	14
Synthesis and biological evaluation of novel imidazo[1,2-a]pyridine-oxadiazole hybrids as anti-proliferative agents: Study of microtubule polymerization inhibition and DNA binding	14
Recent progress and challenges for polymeric microsphere compared to nanosphere drug release systems: Is there a real difference?	14
New coumarin/sulfocoumarin linked phenylacrylamides as selective transmembrane carbonic anhydrase inhibitors: Synthesis and in-vitro biological evaluation	14
Yohimbine as a Starting Point to Access Diverse Natural Product-Like Agents with Re-programmed Activities against Cancer-Relevant GPCR Targets	14
Junctions in DNA: underexplored targets for therapeutic intervention	14
Design and synthesis of 1,3-benzothiazinone derivatives as potential anti-inflammatory agents	14
Discovery and optimization of pyrazolopyrimidine sulfamates as ATG7 inhibitors	14
Novel 1,3,4-oxadiazole compounds inhibit the tyrosinase and melanin level: Synthesis, in-vitro, and in-silico studies	13
Decades-old renin inhibitors are still struggling to find a niche in antihypertensive therapy. A fleeting look at the old and the promising new molecules	13
Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2	13
Dual-responsive drug release and fluorescence imaging based on disulfide-pillar[4]arene aggregate in cancer cells	13
pH-responsive Mannose-modified ferrocene Metal-Organic frameworks with rare earth for Tumor-targeted synchronous Chemo/Chemodynamic therapy	13
PNA-Based Dynamic Combinatorial Libraries (PDCL) and screening of lectins	13
Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity	13
An assessment of the mutational load caused by various reactions used in DNA encoded libraries	13
New acrylamide-sulfisoxazole conjugates as dihydropteroate synthase inhibitors	13
Synthesis and evaluation of heterocycle structures as potential inhibitors of Mycobacterium tuberculosis UGM	13
Conformational analysis by NMR and molecular dynamics of adamantane-doxorubicin prodrugs and their assemblies with β-cyclodextrin: A focus on the design of platforms for controlled drug delivery	13
Design, synthesis and biological evaluation of novel acridine and quinoline derivatives as tubulin polymerization inhibitors with anticancer activities	13
1,2,4-Thiadiazole acyclic nucleoside phosphonates as inhibitors of cysteine dependent enzymes cathepsin K and GSK-3β	13
Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain	13
Novel penta-1,4-diene-3-one derivatives containing quinazoline and oxime ether fragments: Design, synthesis and bioactivity	13
Synthetic approaches to unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles and their MAO-B inhibitory activity. A review	13
Synthetic and computational efforts towards the development of peptidomimetics and small-molecule SARS-CoV 3CLpro inhibitors	13
Self-assembly of photosensitive and radiotherapeutic peptide for combined photodynamic-radio cancer therapy with intracellular delivery of miRNA-139-5p	13
Progress towards drug discovery for Friedreich’s Ataxia: Identifying synthetic oligonucleotides that more potently activate expression of human frataxin protein	12
Discovery of benzimidazole derivatives as potent and selective aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with glucose consumption improving activity	12
Discovery of pyrazole N-aryl sulfonate: A novel and highly potent cyclooxygenase-2 (COX-2) selective inhibitors	12
A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens	12
Antifungal polyketide derivatives from the endophytic fungus Aplosporella javeedii	12
Targeting the interaction of β-catenin and TCF/LEF transcription factors to inhibit oncogenic Wnt signaling	12
Design, synthesis of novel 4,5-dihydroisoxazole-containing benzamide derivatives as highly potent FtsZ inhibitors capable of killing a variety of MDR Staphylococcus aureus	12
Secondary metabolites from Isodon ternifolius (D. Don) Kudo and their anticancer activity as DNA topoisomerase IB and Tyrosyl-DNA phosphodiesterase 1 inhibitors	12
The subgroup of 2′-hydroxy-flavonoids: Molecular diversity, mechanism of action, and anticancer properties	12
Methods to generate site-specific conjugates of antibody and protein	12
Carbon nanomaterials as emerging nanotherapeutic platforms to tackle the rising tide of cancer – A review	12
Trypanocidal activity of new 1,6-diphenyl-1H-pyrazolo[3,4-b]pyridine derivatives: Synthesis, in vitro and in vivo studies	12
Fused chromeno and quinolino[1,8]naphthyridines: Synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents	12
JNK selective inhibitor, IQ-1S, protects the mice against lipopolysaccharides-induced sepsis	12
Design, synthesis and antitumor activity of novel thiophene- triazine derivatives bearing arylurea unit as potent PI3K/mTOR inhibitorss	12
Site-specific covalent labeling of His-tag fused proteins with N-acyl-N-alkyl sulfonamide reagent	12
Nitrile-based peptoids as cysteine protease inhibitors	12
Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents	12
Synthesis and biological evaluation of a ring analogs of the selective CB2 inverse agonist SMM-189	12
Ximaoglaucumins A − F, new cembranoids with anti-inflammatory activities from the South China Sea soft coral Sarcophyton glaucum	12
Carbazole-based fluorescent probes for G-quadruplex DNA targeting with superior selectivity and low cytotoxicity	12
Further SAR studies on natural template based neuroprotective molecules for the treatment of Alzheimer’s disease	12
Synthesis and biological evaluation of NQO1-activated prodrugs of podophyllotoxin as antitumor agents	12
Antimalarial and anti-inflammatory activities of new chloroquine and primaquine hybrids: Targeting the blockade of malaria parasite transmission	12
A minimally-masked inactive prodrug of panobinostat that is bioorthogonally activated by gold chemistry	12
Lead optimization of 2-hydroxymethyl imidazoles as non-hydroxamate LpxC inhibitors: Discovery of TP0586532	12
Novel arylcarbamate-N-acylhydrazones derivatives as promising BuChE inhibitors: Design, synthesis, molecular modeling and biological evaluation	12
Structure-activity relationship analyses of fusidic acid derivatives highlight crucial role of the C-21 carboxylic acid moiety to its anti-mycobacterial activity	12
Versatile near-infrared fluorescent probe for in vivo detection of Aβ oligomers	12
Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors	12
Design and synthesis of novel pyrrolo[2,3-b]pyridine derivatives targeting V600EBRAF	12
Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry	12
Design, synthesis, and antitumor activity evaluation of novel acyl sulfonamide spirodienones	11
Synthesis and biological evaluation of all possible inosine-mixed cyclic dinucleotides that activate different hSTING variants	11
Novel indolylarylsulfone derivatives as covalent HIV-1 reverse transcriptase inhibitors specifically targeting the drug-resistant mutant Y181C	11
Antitumor and toxicity study of mitochondria-targeted triptolide derivatives using triphenylphosphine (TPP+) as a carrier	11
Recent advances on synthesis and biological activities of C-17 aza-heterocycle derived steroids	11
Bisbenzylisoquinoline alkaloids and P-glycoprotein function: A structure activity relationship study	11
Sinomenine inhibits hypoxia induced breast cancer side population cells metastasis by PI3K/Akt/mTOR pathway	11
Discovery of potent and selective reversible Bruton’s tyrosine kinase inhibitors	11
Harmine-inspired design and synthesis of benzo[d]imidazo[2,1-b]thiazole derivatives bearing 1,3,4-oxadiazole moiety as potential tumor suppressors	11
Immunomodulation-mediated anticancer activity of a novel compound from Brugmansia suaveolens leaves	11
Discovery of 4-amino-1H-pyrazolo[3,4-d]pyrimidin derivatives as novel discoidin domain receptor 1 (DDR1) inhibitors	11
Synthesis and biological evaluation of 2-(4-alkoxy-3-cyano)phenylpyrimidine derivatives with 4-amino or 4-hydroxy as a pharmacophore element binding with xanthine oxidase active site	11
Synthesis and evaluation of glycosylated quercetin to enhance neuroprotective effects on cerebral ischemia-reperfusion	11
Resveratrol inhibited hepatocyte apoptosis and alleviated liver fibrosis through miR-190a-5p /HGF axis	11
Insights into non-peptide small-molecule inhibitors of the PD-1/PD-L1 interaction: Development and perspective	11
Design, synthesis, and antitumor activity evaluation of steroidal oximes	11
Design, synthesis and biological evaluation of novel thiohydantoin derivatives as potent androgen receptor antagonists for the treatment of prostate cancer	11
Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in Alzheimer’s disease model mice	11
Soloxolone methyl, as a 18βH-glycyrrhetinic acid derivate, may result in endoplasmic reticulum stress to induce apoptosis in breast cancer cells	11
Iodinated 1,2-diacylhydrazines, benzohydrazide-hydrazones and their analogues as dual antimicrobial and cytotoxic agents	11
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay	11
Uridine natural products: Challenging targets and inspiration for novel small molecule inhibitors	11
Synthesis of six-membered carbocyclic ring α,α-disubstituted amino acids and arginine-rich peptides to investigate the effect of ring size on the properties of the peptide	11
A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism	11
Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell line	11
Biphenyl-based small molecule inhibitors: Novel cancer immunotherapeutic agents targeting PD-1/PD-L1 interaction	11
Synthesis and anticancer potential of novel 5,6-oxygenated and/or halogenated steroidal d-homo lactones	11