Structure

Article	Citations
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	105
The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL	104
A mesophilic Argonaute from Clostridium formicaceticum with efficient DNA cleavage activity guided by small DNA	98
Design of a selective peptide inhibitor targeting KDM5C demethylase activity	87
One bead per residue can describe all-atom protein structures	83
Pocket delipidation induced by membrane tension or modification leads to a structurally analogous mechanosensitive channel state	54
High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1	47
Crystal structure of the lipid flippase MurJ in a “squeezed” form distinct from its inward- and outward-facing forms	45
Structural and functional insights into the mechanism by which MutS2 recognizes a DNA junction	45
Structures of an active type III-A CRISPR effector complex	44
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics	43
ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr	42
The next decade in structural biology	41
GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution	41
Gentle ions for cryo-FIB milling	41
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin	40
Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus	40
Structural insight into CD93 recognition by IGFBP7	39
Cryo-EM structure of the SPFH-NfeD family protein complex QmcA-YbbJ	39
Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET	38
Structural comparison of typical and atypical E2 pestivirus glycoproteins	38
Computational design and improvement of a broad influenza virus HA stem targeting antibody	37
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a	37
Structural insights into ZBTB20 action at the AFP promoter	37
The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP	37

Structural basis of phage transcriptional regulation	36
Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity	35
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps	35
Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA	35
PMSPcnn: Predicting protein stability changes upon single point mutations with convolutional neural network	35
Desensitization dynamics of the AMPA receptor	34
Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ	33
The relationship between interfacial overlap and functional divergence in the yeast protein-protein interaction network	32
Benchmarking AlphaFold2 on peptide structure prediction	31
Lysozyme revisited	31
Structural basis of selective beta-carotene binding by a soluble protein	31
The critical importance of conditions: Reconciling GPCR functionality and biophysical findings	31
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA	29
Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging	29
They all rock: A systematic comparison of conformational movements in LeuT-fold transporters	29
Mg2+-dependent mechanism of environmental versatility in a multidrug efflux pump	28
Discovery and characterization of a pan-betacoronavirus S2-binding antibody	27
Structural basis for the ligand promiscuity of the hydroxamate siderophore binding protein FtsB from Streptococcus pyogenes	27
Correlative cryo-soft X-ray tomography and cryo-structured illumination microscopy reveal changes to lysosomes in amyloid-β-treated neurons	27
Understanding the structural and functional diversity of ATP-PPases using protein domains and functional families in the CATH database	27
Structure of a type II SMC Wadjet complex from Neobacillus vireti	27
Gating mechanism of the human α1β GlyR by glycine	27
Structural insights into the regulation of peptidoglycan DL-endopeptidases by inhibitory protein IseA	26
Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A	26
Cryo-EM structure of the Agrobacterium tumefaciens T4SS-associated T-pilus reveals stoichiometric protein-phospholipid assembly	26
Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii	26
Interplay between intrinsic flexibility and sugar coating in Contactin-2 homodimerization	26
Structural and thermodynamic classification of amyloid polymorphs	25
Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis	25
Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel	25
Physicochemical features of subunit interfaces and their role in self-assembly across the ferritin superfamily	24
Modeling phase separation of biomolecular condensates with data-driven mass-conserving reaction-diffusion systems	24
Septin assemblies promote the lipid organization of membranes	24
The respiratory supercomplex from C. glutamicum	24
Molecular insights into the initiation step of the Rcs signaling pathway	23
Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown	23
Near-atomic cryo-EM structure of the light-harvesting complex LH2 from the sulfur purple bacterium Ectothiorhodospira haloalkaliphila	23
Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling	22
Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium	22
Cryo-EM research in India	22
TcpA from the Clostridium perfringens plasmid pCW3 is more closely related to the DNA translocase FtsK than to coupling proteins	22
Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease	22
Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1	22
Structural mechanism of HP1⍺-dependent transcriptional repression and chromatin compaction	22
Intracellular tau fragment droplets serve as seeds for tau fibrils	21
One RING to rule them all: Mind bomb-1 ccRING3 controls Notch signaling	21
Structural elucidation of the mesothelin-mucin-16/CA125 interaction	21
Crystal structure of blue laccase BP76, a unique termite suicidal defense weapon	21
Structural review of SARS-CoV-2 antiviral targets	20
Computational modeling and prediction of deletion mutants	20

Doublet microtubule inner junction protein FAP20 recruits tubulin to the microtubule lattice	20
PDB-wide identification of physiological hetero-oligomeric assemblies based on conserved quaternary structure geometry	20
Human V-ATPase function is positively and negatively regulated by TLDc proteins	20
Ribosome-inactivation by a class of widely distributed C-tail anchored membrane proteins	20
NaV1.2 EFL domain allosterically enhances Ca2+ binding to sites I and II of WT and pathogenic calmodulin mutants bound to the channel CTD	19
Structure of a putative terminal amidation domain in natural product biosynthesis	19
Geometry-aware template matching for cryo-electron tomograms in Dynamo	19
Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis	19
Anillin-related Mid1 as an adaptive and multimodal contractile ring anchoring protein: A simulation study	19
PARG inhibition induces nuclear aggregation of PARylated PARP1	19
Disulfide-stabilized diabodies enable near-atomic cryo-EM imaging of small proteins: A case study of the bacterial Na+/citrate symporter CitS	19
Disorder in CENP-ACse4 tail-chaperone interaction facilitates binding with Ame1/Okp1 at the kinetochore	18
Integrating protein sequence design and evolutionary sequence conservation to uncover spectral tuning sites in red-light photoreceptors	18
Structural basis for different membrane-binding properties of E. coli anaerobic and human mitochondrial β-oxidation trifunctional enzymes	18
Putting the brakes on endocytosis	18
Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome	18
A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193	18
Structurally diverse C-terminal accessory domains in type I ABC importers reveal distinct regulatory mechanisms	18
Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity	18
Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD	17
Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain	17
Structure of the HapX:CCAAT-binding protein complex with DNA: A piece of the puzzle revealed	17
The interconnecting hairpin extension "arm": An essential allosteric element of phytochrome activity	17
Get what you want: Identifying antibodies against pre-defined epitopes on Frizzled receptors	17
Structural insights into highly similar spatial organization of zinc-finger associated domains with a very low sequence similarity	17
We con-dense if we want to; We can’t leave AZUL outside	17
Computational and biochemical analysis of type IV pilus dynamics and stability	17
Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases	16
Structural basis for the RNA binding properties of mouse IGF2BP3	16
Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism	16
EnsembleFlex: Protein structure ensemble analysis made easy	16
Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis	16
Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation	16
How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor	16
Pho pictures provide powerful perspectives of phosphate importing proteins	16
Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor	16
A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability	16
Chemical modulation of microtubule structure through the laulimalide/peloruside site	16
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2	15
Mechanism of negative μ-opioid receptor modulation by sodium ions	15
Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation	15
A memetic algorithm enables efficient local and global all-atom protein-protein docking with backbone and side-chain flexibility	15
Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum	15
Protein structure prediction using residue-resolved protection factors from hydrogen-deuterium exchange NMR	15
Structure and interactions of the phloem lectin (phloem protein 2) Cus17 from Cucumis sativus	15
Structure and dynamics of a nucleosome core particle based on Widom 603 DNA sequence	15
Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors	15
The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition	15
Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex	15
The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis	15
The molecular basis of allostery in a facilitated dissociation process	15
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand	15
Targeting adhesion G protein-coupled receptors. Current status and future perspectives	14
A new twin expands the VirB8-like protein family	14
Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA	14
The human touch: Utilizing AlphaFold 3 to analyze structures of endogenous metabolons	14
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network	14
Rewiring protein binding specificity in paralogous DRG/DFRP complexes	14
Cryo-EM structure of the RfxCas13d-crRNA-off-target-RNA complex	14
Pulling the wool over a pathogen’s eyes: Llama nanobody inhibitors of the bacterial SOS response	14
New beginnings	14
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis	14
Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus	14
A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization	14
Force-induced unfolding of an antibiotic-bound outer-membrane protein	14
Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III	14
Structural basis of bacteriophage lambda capsid maturation	14
High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing	14
Structural organization of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina acetivorans	14
The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody	13
Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook	13
Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation	13
Architecture of an embracing lipase-foldase complex of the type II secretion system of Acinetobacter baumannii	13
AI-guided cryo-EM analysis untangles uromodulin lattices that safeguard kidneys	13
The ABC transporter MsbA in a dozen environments	13
Solid-state NMR studies of amyloids	13
Membrane mimetic-dependence of GPCR energy landscapes	13
Structural insights into IL-31 signaling inhibition by a neutralizing antibody	13
An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data	13
Structure determination of a DNA crystal by MicroED	13

Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	13
CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs	13
One enzyme, many substrates: How the vaccinia virus enzyme D9 decaps host and viral mRNAs alike	12
Computational microbiology of bacteria: Advancements in molecular dynamics simulations	12
Exploring protein-protein interactions at the proteome level	12
Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase	12
Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev	12
Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae	12
PAS domain of flagellar histidine kinase FlrB has a unique architecture and binds heme as a sensory ligand in an unconventional fashion	12
Structural requirements for activity of Mind bomb1 in Notch signaling	12
Molecular basis for pH sensing in the KDEL trafficking receptor	11
Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy	11
Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser	11
Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism	11
Markerauto2: A fast and robust fully automatic fiducial marker-based tilt series alignment software for electron tomography	11
Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane	11
Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2	11
Mechanism of negative membrane curvature generation by I-BAR domains	11
Insights into the distinct membrane targeting mechanisms of WDR91 family proteins	11
Fungal kinesin-8 motors dimerize by folding their proximal tail domain into a compact helical bundle	11
Structural basis for the carotenoid binding and transport function of a START domain	11
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist	11
Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks	10
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV	10
A glimpse into Giardia lamblia unique translational machinery	10
Native mass spectrometry prescreening of G protein-coupled receptor complexes for cryo-EM structure determination	10
The future of integrated structural biology	10
Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers	10
Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1	10
Structures and mRNP remodeling mechanism of the TREX-2 complex	10
The molecular mechanisms of visual chromophore release from cellular retinaldehyde-binding protein	10
Aberrant tau condensates as catalytic microcompartments propel tau fibrillation	10
Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus	10
Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells	10
SeaMoon: From protein language models to continuous structural heterogeneity	10
Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding	10
Stabilization of F-actin by Salmonella effector SipA resembles the structural effects of inorganic phosphate and phalloidin	10
Acid-stable capsid structure of Helicobacter pylori bacteriophage KHP30 by single-particle cryoelectron microscopy	10
Selection and structural characterization of anti-TREM2 scFvs that reduce levels of shed ectodomain	10
AutoRNC: An automated modeling program for building atomic models of ribosome-nascent chain complexes	10
Structure of the divergent human astrovirus MLB capsid spike	9
Structural basis of λCII-dependent transcription activation	9
Two heads are better than one: Cooperation of two CAPS domains in membrane binding	9
Llamanade: An open-source computational pipeline for robust nanobody humanization	9
Molecular mechanisms underlying the role of the centriolar CEP164-TTBK2 complex in ciliopathies	9
Triangulating variation in the population to define mechanisms for precision management of genetic disease	9
High-resolution crystal structure and chemical screening reveal pantothenate kinase as a new target for antifungal development	9
Mind the gap	9
Unveiling the intriguing role of FAP20 in tubulin recruitment at the doublet microtubule inner junctions	9
Native state fluctuations in a peroxiredoxin active site match motions needed for catalysis	9
Structure, dynamics, and function of PsDef2 defensin from Pinus sylvestris	9
X-rays, electrons, and neutrons as probes of atomic matter	9
Addressing compressive deformation of proteins embedded in crystalline ice	9
DNA ligase and PCNA: Double-ring down to seal a break in DNA	9
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4	9
Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome	9