Structure

Article	Citations
Structural comparison of typical and atypical E2 pestivirus glycoproteins	121
Crystal structure of the lipid flippase MurJ in a “squeezed” form distinct from its inward- and outward-facing forms	115
Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus	96
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin	60
Structures of an active type III-A CRISPR effector complex	60
Gentle ions for cryo-FIB milling	54
GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution	53
The next decade in structural biology	52
ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr	49
One bead per residue can describe all-atom protein structures	48
Cryo-EM structure of the SPFH-NfeD family protein complex QmcA-YbbJ	48
Structural insight into CD93 recognition by IGFBP7	46
Structural and functional insights into the mechanism by which MutS2 recognizes a DNA junction	45
High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1	44
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics	43
The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL	43
Design of a selective peptide inhibitor targeting KDM5C demethylase activity	43
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	42
Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET	41
Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly, structure, and activity	40
A mesophilic Argonaute from Clostridium formicaceticum with efficient DNA cleavage activity guided by small DNA	40
Nanobodies restore stability to cancer-associated mutants of tumor suppressor protein p16INK4a	39
Seeing is believing—Plasmodium falciparum translation in action	38
Structural basis of selective beta-carotene binding by a soluble protein	35
The relationship between interfacial overlap and functional divergence in the yeast protein-protein interaction network	35

Computational design and improvement of a broad influenza virus HA stem targeting antibody	35
Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ	34
Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA	34
Structural insights into ZBTB20 action at the AFP promoter	33
Cryo-EM structure of the vault from human brain reveals symmetry mismatch at its caps	32
Desensitization dynamics of the AMPA receptor	31
TMEM55B—Jack of all trades in the endo-lysosomal system?	30
PMSPcnn: Predicting protein stability changes upon single point mutations with convolutional neural network	30
Benchmarking AlphaFold2 on peptide structure prediction	30
Coiled-coil-mediated phase separation of Spef1 for central-pair microtubule organization and function	29
Dynamics of the PAC1 receptor in apo, peptide agonist-bound, and G protein complexed states	29
Structural basis of phage transcriptional regulation	29
They all rock: A systematic comparison of conformational movements in LeuT-fold transporters	28
Mechanistic and structural insights into the bifunctional enzyme PaaY from Acinetobacter baumannii	28
Nanoscale conformational dynamics of human propionyl-CoA carboxylase	28
The structure of the R2T complex reveals a different architecture from the related HSP90 cochaperone R2TP	28
Interplay between intrinsic flexibility and sugar coating in Contactin-2 homodimerization	27
Our authors in 2025	27
The critical importance of conditions: Reconciling GPCR functionality and biophysical findings	27
Physicochemical features of subunit interfaces and their role in self-assembly across the ferritin superfamily	26
Structure of a type II SMC Wadjet complex from Neobacillus vireti	26
Cryo-EM structure of the Agrobacterium tumefaciens T4SS-associated T-pilus reveals stoichiometric protein-phospholipid assembly	26
Lysozyme revisited	26
Gating mechanism of the human α1β GlyR by glycine	26
Structural basis for the ligand promiscuity of the hydroxamate siderophore binding protein FtsB from Streptococcus pyogenes	25
Understanding the structural and functional diversity of ATP-PPases using protein domains and functional families in the CATH database	25
Discovery and characterization of a pan-betacoronavirus S2-binding antibody	25
Next-generation small molecule inhibitors of clathrin function acutely inhibit endocytosis	24
Structural insights into the regulation of peptidoglycan DL-endopeptidases by inhibitory protein IseA	24
Structural and thermodynamic classification of amyloid polymorphs	24
Cryo-EM structures of HBV capsids from human cells at near-atomic resolution	24
Correlative cryo-soft X-ray tomography and cryo-structured illumination microscopy reveal changes to lysosomes in amyloid-β-treated neurons	24
Septin assemblies promote the lipid organization of membranes	23
Mg2+-dependent mechanism of environmental versatility in a multidrug efflux pump	23
Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel	23
The HisRS-like domain of GCN2 is a pseudoenzyme that can bind uncharged tRNA	23
Structure of calcineurin bound to PI4KA reveals dual interface in both PI4KA and FAM126A	22
Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown	22
Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging	22
Crystal structure of blue laccase BP76, a unique termite suicidal defense weapon	22
Modeling phase separation of biomolecular condensates with data-driven mass-conserving reaction-diffusion systems	22
Intracellular tau fragment droplets serve as seeds for tau fibrils	21
TcpA from the Clostridium perfringens plasmid pCW3 is more closely related to the DNA translocase FtsK than to coupling proteins	21
Memory engram synapse 3D macromolecular architecture visualized by cryoCLEM-guided cryoET	21
Structures of TASK-1 and TASK-3 K2P channels provide insight into their gating and dysfunction in disease	21
The pyrin domain of IFI16 forms a distinct filament structure important for IFI16-mediated enhancement of STING activation	21
Cryo-EM research in India	21
Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling	20
One RING to rule them all: Mind bomb-1 ccRING3 controls Notch signaling	20
Computational modeling and prediction of deletion mutants	20

Molecular insights into the initiation step of the Rcs signaling pathway	20
Near-atomic cryo-EM structure of the light-harvesting complex LH2 from the sulfur purple bacterium Ectothiorhodospira haloalkaliphila	20
Human V-ATPase function is positively and negatively regulated by TLDc proteins	19
Meet the authors: Cong-Zhao Zhou and Yong-Liang Jiang	19
Ribosome-inactivation by a class of widely distributed C-tail anchored membrane proteins	19
Structural elucidation of the mesothelin-mucin-16/CA125 interaction	19
Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1	19
Get what you want: Identifying antibodies against pre-defined epitopes on Frizzled receptors	18
Doublet microtubule inner junction protein FAP20 recruits tubulin to the microtubule lattice	18
Capture first, then deliver!	18
The interconnecting hairpin extension "arm": An essential allosteric element of phytochrome activity	18
Putting the brakes on endocytosis	18
Geometry-aware template matching for cryo-electron tomograms in Dynamo	18
Structural insights into zinc piracy by Neisseria gonorrhoeae to overcome nutritional immunity	18
We con-dense if we want to; We can’t leave AZUL outside	18
Disulfide-stabilized diabodies enable near-atomic cryo-EM imaging of small proteins: A case study of the bacterial Na+/citrate symporter CitS	18
Structural review of SARS-CoV-2 antiviral targets	18
Structural basis for different membrane-binding properties of E. coli anaerobic and human mitochondrial β-oxidation trifunctional enzymes	18
Structural mechanism of HP1⍺-dependent transcriptional repression and chromatin compaction	18
Conformational exchange divergence along the evolutionary pathway of eosinophil-associated ribonucleases	17
Structure of the HapX:CCAAT-binding protein complex with DNA: A piece of the puzzle revealed	17
Cullin-independent recognition of HHARI substrates by a dynamic RBR catalytic domain	17
Structure of the poxvirus decapping enzyme D9 reveals its mechanism of cap recognition and catalysis	17
Antimalarial drug artemisinin stabilizes PfRACK1 binding to the ribosome	17
Structural insights into highly similar spatial organization of zinc-finger associated domains with a very low sequence similarity	17
Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD	17
Integrating protein sequence design and evolutionary sequence conservation to uncover spectral tuning sites in red-light photoreceptors	17
Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis	17
A comprehensive structural analysis of the ATPase domain of human DNA topoisomerase II beta bound to AMPPNP, ADP, and the bisdioxopiperazine, ICRF193	17
Structure of a putative terminal amidation domain in natural product biosynthesis	16
Disorder in CENP-ACse4 tail-chaperone interaction facilitates binding with Ame1/Okp1 at the kinetochore	16
Structurally diverse C-terminal accessory domains in type I ABC importers reveal distinct regulatory mechanisms	16
Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors	16
The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis	16
PARG inhibition induces nuclear aggregation of PARylated PARP1	16
Meet the author: Constantinos Kurt Wibmer	16
Characterization of synthetic antigen binding fragments targeting Toc75 for the isolation of TOC in A. thaliana and P. sativum	16
Pho pictures provide powerful perspectives of phosphate importing proteins	16
A memetic algorithm enables efficient local and global all-atom protein-protein docking with backbone and side-chain flexibility	16
Structural and functional insights into yeast Tbf1 as an atypical telomeric repeat-binding factor	16
Berberine analog of chloramphenicol exhibits a distinct mode of action and unveils ribosome plasticity	16
Anillin-related Mid1 as an adaptive and multimodal contractile ring anchoring protein: A simulation study	16
Structure and dynamics of a nucleosome core particle based on Widom 603 DNA sequence	16
Complementary structures of the yeast phosphate transporter Pho90 provide insights into its transport mechanism	16
Structure of E6AP in complex with HPV16-E6 and p53 reveals a novel ordered domain important for E3 ligase activation	15
Chemical modulation of microtubule structure through the laulimalide/peloruside site	15
Bacillus subtilis MutL samples multiple conformations during nucleotide binding and hydrolysis	15
Ligand flexibility and binding pocket malleability cooperate to allow selective PXR activation by analogs of a promiscuous nuclear receptor ligand	15
How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor	15
Structural and biochemical characterization of neutralizing antibodies targeting human papillomavirus type 45	15
Structure of the RhlR-PqsE complex from Pseudomonas aeruginosa reveals mechanistic insights into quorum-sensing gene regulation	15
EnsembleFlex: Protein structure ensemble analysis made easy	15
Structural changes shifting the redox potential of the outlying cluster N1a in respiratory complex I	15
prismPYP: Power-spectrum and image domain learning for self-supervised micrograph evaluation	15
Cryo-EM structure of the R388 plasmid conjugative pilus reveals a helical polymer characterized by an unusual pilin/phospholipid binary complex	15
Discovery of tankyrase scaffolding inhibitor specifically targeting the ARC4 peptide binding domain	15
A correlative workflow for synaptic imaging by cryo-electron tomography	15
A structural dendrogram of the actinobacteriophage major capsid proteins provides important structural insights into the evolution of capsid stability	14
Pulling the wool over a pathogen’s eyes: Llama nanobody inhibitors of the bacterial SOS response	14
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis	14
Cryo-EM structure of the RfxCas13d-crRNA-off-target-RNA complex	14
Structure and interactions of the phloem lectin (phloem protein 2) Cus17 from Cucumis sativus	14
The human touch: Utilizing AlphaFold 3 to analyze structures of endogenous metabolons	14
High throughput mutational characterization of the GPCR ligand C5a using yeast display and deep sequencing	14
Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA	14
Rewiring protein binding specificity in paralogous DRG/DFRP complexes	14
Structural basis for the RNA binding properties of mouse IGF2BP3	14
A new twin expands the VirB8-like protein family	14
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2	14
The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition	14
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network	14
Mechanism of negative μ-opioid receptor modulation by sodium ions	13
In silico design of stable single-domain antibodies with high affinity	13
One enzyme, many substrates: How the vaccinia virus enzyme D9 decaps host and viral mRNAs alike	13
Structural insights into IL-31 signaling inhibition by a neutralizing antibody	13
CAND1 and CAND2 drive CUL4 substrate receptor exchange with largely comparable biochemical efficiency, unlike their relative effects on CUL1	13
Structural basis of microtubule depolymerization by the kinesin-like activity of HIV-1 Rev	13
Solid-state NMR studies of amyloids	13
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif	13
Targeting adhesion G protein-coupled receptors. Current status and future perspectives	13

Rethinking what pLDDT really tells us about protein flexibility	13
Bacillus subtilis MutL samples multiple conformations during nucleotide binding and hydrolysis	13
CryoVIA: An image analysis toolkit for the quantification of membrane structures from cryo-EM micrographs	12
AI-guided cryo-EM analysis untangles uromodulin lattices that safeguard kidneys	12
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	12
The N terminus of H3-influenza hemagglutinin as a site-of-vulnerability to neutralizing antibody	12
Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation	12
Structure determination of a DNA crystal by MicroED	12
Computational microbiology of bacteria: Advancements in molecular dynamics simulations	12
Characterization of the Pro101Gln mutation that enhances the catalytic performance of T. indicus NADH-dependent d-lactate dehydrogenase	12
Structural requirements for activity of Mind bomb1 in Notch signaling	12
Membrane mimetic-dependence of GPCR energy landscapes	12
Review of serial femtosecond crystallography including the COVID-19 pandemic impact and future outlook	12
The ABC transporter MsbA in a dozen environments	12
Structural organization of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina acetivorans	12
Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus	12
An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data	12
Structures and mRNP remodeling mechanism of the TREX-2 complex	11
Structural basis for the carotenoid binding and transport function of a START domain	11
Inter-subunit crosstalk via PDZ synergistically governs allosteric activation of proapoptotic HtrA2	11
Structure and mechanism of sulfofructose transaldolase, a key enzyme in sulfoquinovose metabolism	11
Fungal kinesin-8 motors dimerize by folding their proximal tail domain into a compact helical bundle	11
Structural insights into the FtsEX-EnvC complex regulation on septal peptidoglycan hydrolysis in Vibrio cholerae	11
Structural basis for the inhibition mechanism of the DNA polymerase holoenzyme from mpox virus	11
Trace_y: Software algorithms for structural analysis of individual helical filaments by three-dimensional contact point reconstruction atomic force microscopy	11
Quantitative structural analysis of influenza virus by cryo-electron tomography and convolutional neural networks	11
A mechanistic understanding of how KCNE1 tunes KCNQ1 channel pharmacology	11
AutoRNC: An automated modeling program for building atomic models of ribosome-nascent chain complexes	11
Structural basis of signaling complex inhibition by IL-6 domain-swapped dimers	11
PAS domain of flagellar histidine kinase FlrB has a unique architecture and binds heme as a sensory ligand in an unconventional fashion	11
Room-temperature structural studies of SARS-CoV-2 protein NendoU with an X-ray free-electron laser	11
Two cooperative lipid binding sites within the pleckstrin homology domain are necessary for AKT binding and stabilization to the plasma membrane	11
Insights into the distinct membrane targeting mechanisms of WDR91 family proteins	11
A comprehensive engineering strategy improves potency and manufacturability of a near pan-neutralizing antibody against HIV	11
Cryogenic electron tomography and elemental analysis of mitochondrial granules in human retinal ganglion cells	11
Architecture of an embracing lipase-foldase complex of the type II secretion system of Acinetobacter baumannii	11
Markerauto2: A fast and robust fully automatic fiducial marker-based tilt series alignment software for electron tomography	11
SeaMoon: From protein language models to continuous structural heterogeneity	11
Aberrant tau condensates as catalytic microcompartments propel tau fibrillation	10
The future of integrated structural biology	10
Two heads are better than one: Cooperation of two CAPS domains in membrane binding	10
Protein model building for intermediate-resolution cryo-EM maps by integrating evolutionary and experimental information	10
Mind the gap	10
Unveiling the intriguing role of FAP20 in tubulin recruitment at the doublet microtubule inner junctions	10
Molecular basis for pH sensing in the KDEL trafficking receptor	10
Meet the author: Cathleen Zeymer	10
Chaperone-assisted cryo-EM structure of P. aeruginosa PhuR reveals molecular basis for heme binding	10
Addressing compressive deformation of proteins embedded in crystalline ice	10
Soft X-ray tomography illuminates drug-induced changes in insulin granules	10
Structural basis of λCII-dependent transcription activation	10
Structural basis for inhibition of the lysosomal two-pore channel TPC2 by a small molecule antagonist	10
Triangulating variation in the population to define mechanisms for precision management of genetic disease	10
Cryo-EM structures of photocomplexes from the free-living aerobic anoxygenic phototrophic bacterium Erythrobacter sanguineus	10
Single-particle cryo-EM analysis of the shell architecture and internal organization of an intact α-carboxysome	10
Structure, dynamics, and function of PsDef2 defensin from Pinus sylvestris	10