Structure

Article	Citations
Meet the authors: Dr. Eva Huber, Dr. Michael Groll, and Dr. Eric Ortlund	87
The structures of the peptide transporters SLC15A3 and SLC15A4 reveal the recognition mechanisms for substrate and TASL	82
The structure of a NEMO construct engineered for screening reveals novel determinants of inhibition	74
Direct effect of membrane environment on the activation of mGluR2 revealed by single-molecule FRET	71
Conformational response of αIIbβ3 and αVβ3 integrins to force	69
Structural insights into polyisoprenyl-binding glycosyltransferases	65
Structural insights into the biochemical mechanism of the E2/E3 hybrid enzyme UBE2O	56
Gentle ions for cryo-FIB milling	52
Structure of a zoonotic H5N1 hemagglutinin reveals a receptor-binding site occupied by an auto-glycan	49
Structural insights into human ABCA7-mediated lipid transport	48
Structure-guided insights into TIR-mediated bacterial and eukaryotic immunity	47
A novel interleukin-10 antibody graft to treat inflammatory bowel disease	45
Heterocomplex structure of a polyketide synthase component involved in modular backbone halogenation	43
Structural insights from G-protein-coupled receptor complexes enable the rational engineering of improved light-activated designer receptors	42
An integrative approach unveils a distal encounter site for rPTPε and phospho-Src complex formation	40
Cryo-EM study of patched in lipid nanodisc suggests a structural basis for its clustering in caveolae	38
Structure of Anabaena flos-aquae gas vesicles revealed by cryo-ET	38
A unique leucine-valine adhesive motif supports structure and function of protein disulfide isomerase P5 via dimerization	37
Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX	37
Insights into substrate coordination and glycosyl transfer of poplar cellulose synthase-8	37
Crystal structure of archaeal IF5A-DHS complex reveals insights into the hypusination mechanism	36
Ordering the disordered	35
Engineering of pH-dependent antigen binding properties for toxin-targeting IgG1 antibodies using light-chain shuffling	35
Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain	34
Propelling COPII vesicle biogenesis at the endoplasmic reticulum	33

Catalytic cycling of human mitochondrial Lon protease	33
Cryo-EM structures of human fucosidase FucA1 reveal insight into substrate recognition and catalysis	33
A new visual design language for biological structures in a cell	32
A new twin expands the VirB8-like protein family	32
Force-induced unfolding of an antibiotic-bound outer-membrane protein	32
Pulling the wool over a pathogen’s eyes: Llama nanobody inhibitors of the bacterial SOS response	31
Cullin(g) glutamate dehydrogenase: Insights into multivalent CRL3KLHL22 substrate recognition	30
Mechanistic insight into light-dependent recognition of Timeless by Drosophila Cryptochrome	30
Scaling up cryo-EM for biology and chemistry: The journey from niche technology to mainstream method	30
Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response	30
Crystal structure of the alternative complex III from the phototrophic bacterium Chloroflexus aurantiacus	29
The guidance and adhesion protein FLRT2 dimerizes in cis via dual small-X3-small transmembrane motifs	28
Does the structure of transthyretin amyloid fibrils vary depending on the organ of accumulation?	28
Structural and biochemical insights into the mechanism of the anti-CRISPR protein AcrIE3	28
Structural insight into CD93 recognition by IGFBP7	28
Crystal structure of the lipid flippase MurJ in a “squeezed” form distinct from its inward- and outward-facing forms	27
The next decade in structural biology	27
Crystal structure of the CDK11 kinase domain bound to the small-molecule inhibitor OTS964	27
New beginnings	27
The hitchhiker's guide to the periplasm: Unexpected molecular interactions of polymyxin B1 in E. coli	27
Structural comparison of typical and atypical E2 pestivirus glycoproteins	26
Chaperoning the major facilitator superfamily at single-molecule level	26
Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein	25
Mapping structural and dynamic divergence across the MBOAT family	25
Cryo-EM structure of the SPFH-NfeD family protein complex QmcA-YbbJ	25
Trading in catalytic power for sensing	25
Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins	24
Simplified quality assessment for small-molecule ligands in the Protein Data Bank	24
Cryo-EM structure of an open conformation of a gap junction hemichannel in lipid bilayer nanodiscs	24
Structure-guided optimization of light-activated chimeric G-protein-coupled receptors	24
Structural analysis of Mycobacterium tuberculosis M13 metalloprotease Zmp1 open states	24
ATP-site inhibitors induce unique conformations of the acute myeloid leukemia-associated Src-family kinase, Fgr	23
Pocket delipidation induced by membrane tension or modification leads to a structurally analogous mechanosensitive channel state	23
A standard data format for 3DED/MicroED	23
Structure and interactions of the phloem lectin (phloem protein 2) Cus17 from Cucumis sativus	23
Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding	23
Multiple masks of a Shigella podophage	23
Lys716 in the transmembrane domain of yeast mitofusin Fzo1 modulates anchoring and fusion	22
Cryo-EM structure of flagellotropic bacteriophage Chi	22
Structural basis of bacteriophage lambda capsid maturation	22
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	22
Structural characterization of the POTRA domains from A. baumannii reveals new conformations in BamA	22
Mechanism of ceramide synthase inhibition by fumonisin B1	22
Treatment of noise caused by radiation damage during cryo-EM data collection	22
Ping, pong, and freeze: Structural insights into the inhibition of ceramide synthase by Fumonisin B1	21
Visualization of hydrogen atoms in a perdeuterated lectin-fucose complex reveals key details of protein-carbohydrate interactions	21
Structure-based modeling and dynamics of MurM, a Streptococcus pneumoniae penicillin resistance determinant present at the cytoplasmic membrane	21
Mechanism of phospho-Ubls’ specificity and conformational changes that regulate Parkin activity	21
Structure and dynamics of the active site of hen egg-white lysozyme from atomic resolution neutron crystallography	21
Structural dissection of the CMP-pseudaminic acid synthetase, PseF	21

Rewiring protein binding specificity in paralogous DRG/DFRP complexes	20
Mechanism of negative μ-opioid receptor modulation by sodium ions	20
Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM	20
Advances in the field of RNA 3D structure prediction and modeling, with purely theoretical approaches, and with the use of experimental data	19
The accuracy of protein structures in solution determined by AlphaFold and NMR	19
Structural and functional characterization of the N-terminal acetyltransferase Naa50	19
PROTAC-mediated activation, rather than degradation, of a nuclear receptor reveals complex ligand-receptor interaction network	19
Evolving cryo-EM structural approaches for GPCR drug discovery	19
A finger that gets in the way: When binding isn’t just about the bound state	19
Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex	19
Molecular basis of RanGTP-activated release of Histones H2A-H2B from Importin-9	18
Polymorphic residues in HLA-B that mediate HIV control distinctly modulate peptide interactions with both TCR and KIR molecules	18
Compressed sensing for electron cryotomography and high-resolution subtomogram averaging of biological specimens	18
Slow conformational dynamics of the human A2A adenosine receptor are temporally ordered	18
Mechanism of heterochromatin remodeling revealed by the DDM1 bound nucleosome structures	18
Polysaccharide assemblies in fungal and plant cell walls explored by solid-state NMR	18
Structures of an active type III-A CRISPR effector complex	18
Structural characterization of Thogoto Virus nucleoprotein provides insights into viral RNA encapsidation and RNP assembly	17
GuaB3, an overlooked enzyme in cyanobacteria's toolbox that sheds light on IMP dehydrogenase evolution	17
Extracellular Fe(III) reductase structure reveals a modular organization enabling S-layer insertion and electron transfer to insoluble substrates	17
Selective deuteration of an RNA:RNA complex for structural analysis using small-angle scattering	17
Structure, function, surf, repeat: A week at Lorne Proteins 2024	17
Targeting adhesion G protein-coupled receptors. Current status and future perspectives	17
Cryo-EM and artificial intelligence visualize endogenous protein community members	16
Structure and regulation of the myotonic dystrophy kinase-related Cdc42-binding kinase	16
Phosphorylation at Ser65 modulates ubiquitin conformational dynamics	16
A monoclonal antibody against staphylococcal enterotoxin B superantigen inhibits SARS-CoV-2 entry in vitro	16
Dual mechanisms of cholesterol-GPCR interactions that depend on membrane phospholipid composition	16
Basis for drug selectivity of plasmepsin IX and X inhibition in Plasmodium falciparum and vivax	15
Cryo-EM structure of the cytosolic AhR complex	15
Structural and functional properties of different types of siphonous LHCII trimers from an intertidal green alga Bryopsis corticulans	15
Soft X-ray tomography to map and quantify organelle interactions at the mesoscale	15
The cards you have been dealt: How an intertidal green macroalga absorbs blue-green light	15
One bead per residue can describe all-atom protein structures	15
Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target	14
Conformational changes and CO2-induced channel gating in connexin26	14
Recent advances in small-angle scattering and its expanding impact in structural biology	14
Structural and functional insights into the mechanism by which MutS2 recognizes a DNA junction	14
Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization	14
Structures of Ric-8B in complex with Gα protein folding clients reveal isoform specificity mechanisms	14
Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA	14
The human touch: Utilizing AlphaFold 3 to analyze structures of endogenous metabolons	14
Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin	14
Roles of the gate loop in β-arrestin-1 conformational dynamics and phosphorylated receptor interaction	14
Protein language-model embeddings for fast, accurate, and alignment-free protein structure prediction	14
A mesophilic Argonaute from Clostridium formicaceticum with efficient DNA cleavage activity guided by small DNA	14
Molecular structures of human ACAT2 disclose mechanism for selective inhibition	14
Chemical probing provides insight into the native assembly state of a bacterial microcompartment	13
Protein translocation through α-helical channels and insertases	13
Structure of the iminium reaction intermediate in an engineered aldolase explains the carboligation activity toward arylated ketones and aldehydes	13
Computational design and improvement of a broad influenza virus HA stem targeting antibody	13
Clamping, bending, and twisting inter-domain motions in the misfold-recognizing portion of UDP-glucose: Glycoprotein glucosyltransferase	13
Structural insights into the role and targeting of EGFRvIII	13
Structural insights into trehalose capture and translocation by mycobacterial LpqY-SugABC	13
The ABC transporter MsbA in a dozen environments	13
Rieske head domain dynamics and indazole-derivative inhibition of Candida albicans complex III	13
Inhibition of Plasmodium falciparum phenylalanine tRNA synthetase provides opportunity for antimalarial drug development	13
Desensitization dynamics of the AMPA receptor	13
Architecture of an embracing lipase-foldase complex of the type II secretion system of Acinetobacter baumannii	13
Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain	12
De novo design of SARS-CoV-2 main protease inhibitors with characteristic binding modes	12
How CEP164 ciliopathy mutations impair ciliogenesis	12
Interplay between hevin, SPARC, and MDGAs: Modulators of neurexin-neuroligin transsynaptic bridges	12
Illuminating cholesterol-mTORC1 signaling: LYCHOS in focus	12
Kenneth C. Holmes (1934–2021)	12
The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis	12
Antigen presentation by MHC-II is shaped by competitive and cooperative allosteric mechanisms of peptide exchange	12
The accuracy of NMR protein structures in the Protein Data Bank	12
Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1	12
Insight into mithramycin disruption of ETS transcription leads to improved understanding of more selective analogs	12
Metal fluorides—multi-functional tools for the study of phosphoryl transfer enzymes, a practical guide	12
Biochemical and structural characterization of the DNA-binding properties of human TRIP4 ASCH domain reveals insights into its functional role	12
Squishy to crusty: Biophysics reveal the molecular details of FUS droplet maturation	11
Molecular rules governing the structural polymorphism of amyloid fibrils in neurodegenerative diseases	11
Molecular mechanism of contactin 2 homophilic interaction	11
Structural basis for accommodation of emerging B.1.351 and B.1.1.7 variants by two potent SARS-CoV-2 neutralizing antibodies	11
The to and fro of Rho	11
Cryo-EM structure of a DNA-PK trimer: higher order oligomerisation in NHEJ	11
Inherent backbone dynamics fine-tune the functional plasticity of Tudor domains	11
Architecture of the bacteriophage lambda tail	11

Two steps, one ligand: How PPARγ binds small-molecule agonists	11
Structural insights into the bifunctional enzyme human FAD synthase	11
High-resolution crystal structures of transient intermediates in the phytochrome photocycle	11
Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core	11
Macromolecular refinement of X-ray and cryoelectron microscopy structures with Phenix/OPLS3e for improved structure and ligand quality	11
It takes two to tango: Rycals and ATP snuggle up to bind ryanodine receptors	11
A road map to structure-resistance correlations on Mycobacterium tuberculosis MmpL3	11
Structure of V-ATPase from citrus fruit	11
Structural requirements for activity of Mind bomb1 in Notch signaling	11
Cohesin-dockerin code in cellulosomal dual binding modes and its allosteric regulation by proline isomerization	10
Structure determination of a DNA crystal by MicroED	10
Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding	10
Membrane mimetic-dependence of GPCR energy landscapes	10
PMSPcnn: Predicting protein stability changes upon single point mutations with convolutional neural network	10
Structural insights into a functional unit from an immunogenic mollusk hemocyanin	10
An engineered construct of cFLIP provides insight into DED1 structure and interactions	10
Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins	10
Activation loop phosphorylation tunes conformational dynamics underlying Pyk2 tyrosine kinase activation	10
EncoMPASS: An encyclopedia of membrane proteins analyzed by structure and symmetry	10
High-resolution cryo-EM of a small protein complex: The structure of the human CDK-activating kinase	10
Structure of an inactive conformation of GTP-bound RhoA GTPase	10
Cobalamin decyanation by the membrane transporter BtuM	10
Go big and go home: A bulky extension makes promiscuous ligands settle down	10
Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: Revealing the mechanism of effector translocation in the T3SS	10
Cooperative mechanics of PR65 scaffold underlies the allosteric regulation of the phosphatase PP2A	10
CELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain	10
Host receptor binding induces conformational changes in a PfEMP1 protein	9
ATTRv-V30M amyloid fibrils from heart and nerves exhibit structural homogeneity	9
Structural insights into the convergent evolution of sulfoxide synthase EgtB-IV, an ergothioneine-biosynthetic homolog of ovothiol synthase OvoA	9
Structural basis of selective beta-carotene binding by a soluble protein	9
Cryo-EM structure of a Shigella podophage reveals a hybrid tail and novel decoration proteins	9
An expanded trove of fragment-bound structures for the allosteric enzyme PTP1B from computational reanalysis of large-scale crystallographic data	9
Frozen in time: analyzing molecular dynamics with time-resolved cryo-EM	9
The solution structure of human leptin reveals a conformational plasticity important for receptor recognition	9
In situ structure of the AcrAB-TolC efflux pump at subnanometer resolution	9
The hidden (degron) truth behind the degradation of DHFR disease-associated variants	9
Tails don’t tell the whole story	9
Unveiling the polarity of actin filaments by cryo-electron tomography	9
αMI-domain of integrin Mac-1 binds the cytokine pleiotrophin using multiple mechanisms	9
Bilayer lipids modulate ligand binding to atypical chemokine receptor 3	9
Prominent role of cysteine residues C49 and C343 in regulating Plasmodium falciparum pyruvate kinase activity	9
The mechanism of allosteric activation of SYK kinase derived from multiple phospho-ITAM-bound structures	9
One enzyme, many substrates: How the vaccinia virus enzyme D9 decaps host and viral mRNAs alike	9
Transient association between proteins elicits alteration of dynamics at sites far away from interfaces	9
Structural organization of pyruvate: ferredoxin oxidoreductase from the methanogenic archaeon Methanosarcina acetivorans	9
Structure-based prediction of Ras-effector binding affinities and design of “branchegetic” interface mutations	9
Conformational dynamics of SARS-CoV-2 Omicron spike trimers during fusion activation at single molecule resolution	9