OOIR: Observatory of International Research

Papers

(The median citation count of Angiogenesis is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization	271
Blood flow regulates acvrl1 transcription via ligand-dependent Alk1 activity	86
Senescent endothelial cells: a potential target for diabetic retinopathy	78
Role of TGFβ1 and WNT6 in FGF2 and BMP4-driven endothelial differentiation of murine embryonic stem cells	75
The role of vasculature and angiogenesis in respiratory diseases	62
Copper stress impairs angiogenesis and lymphangiogenesis during zebrafish embryogenesis by down-regulating pERK1/2-foxm1-MMP2/9 axis and epigenetically regulating ccbe1 expression	59
People with a connective tissue disorder may be especially vulnerable to the endothelial damage that characterizes long COVID due to the fragility of their vasculature and slow wound healing	47
Somatic BrafV600E mutation in the cerebral endothelium induces brain arteriovenous malformations	40
The vascular gene Apold1 is dispensable for normal development but controls angiogenesis under pathological conditions	37
Proinflammatory activity of VEGF-targeted treatment through reversal of tumor endothelial cell anergy	33
Soluble FLT-1 in angiogenesis: pathophysiological roles and therapeutic implications	33
Alk1/Endoglin signaling restricts vein cell size increases in response to hemodynamic cues	32
BMP10 functions independently from BMP9 for the development of a proper arteriovenous network	31
Coalescent angiogenesis—evidence for a novel concept of vascular network maturation	29
PDGFD switches on stem cell endothelial commitment	29
Nectins and Nectin-like molecules drive vascular development and barrier function	28
Persistent endothelial dysfunction in post-COVID-19 syndrome and its associations with symptom severity and chronic inflammation	27
In vivo dissection of Rhoa function in vascular development using zebrafish	27
Endothelial cells require functional FLVCR1a during developmental and adult angiogenesis	27
Multimodality imaging reveals angiogenic evolution in vivo during calvarial bone defect healing	27
Impact of heterozygous ALK1 mutations on the transcriptomic response to BMP9 and BMP10 in endothelial cells from hereditary hemorrhagic telangiectasia and pulmonary arterial hypertension donors	25
FGF21 via mitochondrial lipid oxidation promotes physiological vascularization in a mouse model of Phase I ROP	25
Diminished vasculogenesis under inflammatory conditions is mediated by Activin A	22
Correction: Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats	22
Vascular mimicry in zebrafish fin regeneration: how macrophages build new blood vessels	21

Persistent capillary rarefication in long COVID syndrome	21
Blood vessels sense dermal stiffness via a novel mechanotransducer, APJ	19
On coalescent angiogenesis and the remarkable flexibility of blood vessels	19
Localized conditional induction of brain arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia	18
KIT is dispensable for physiological organ vascularisation in the embryo	18
Effect of oral nintedanib vs placebo on epistaxis in hereditary hemorrhagic telangiectasia: the EPICURE multicenter randomized double-blind trial	17
The rising impact of angiogenesis research	17
CCL4 contributes to aging related angiogenic insufficiency through activating oxidative stress and endothelial inflammation	17
Similarities and differences between brain and skin GNAQ p.R183Q driven capillary malformations	16
Capillary morphogenesis gene 2 (CMG2) mediates growth factor-induced angiogenesis by regulating endothelial cell chemotaxis	16
Role of endothelial PDGFB in arterio-venous malformations pathogenesis	15
Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice	15
MicroRNA-375 repression of Kruppel-like factor 5 improves angiogenesis in diabetic critical limb ischemia	15
Reply to “Embracing imatinib: a novel approach to safeguarding the endothelial barrier in patients with COVID-19”	15
Inhibition of Angiopoietin-2 rescues sporadic brain arteriovenous malformations by reducing pericyte loss	15
Endothelial cell expression of mutant Map2k1 causes vascular malformations in mice	15
Human iPSC and CRISPR targeted gene knock-in strategy for studying the somatic TIE2L914F mutation in endothelial cells	14
S100A4-dependent glycolysis promotes lymphatic vessel sprouting in tumor	14
The influences of ApoE isoforms on endothelial adherens junctions and actin cytoskeleton responding to mCRP	13
Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) drives abnormal pericyte-rich vasculature in triple-negative breast cancer	13
FOXO1 promotes endothelial cell elongation and angiogenesis by up-regulating the phosphorylation of myosin light chain 2	13
Deletion of endothelial α-parvin inhibits tumour angiogenesis, reduces tumour growth and induces tumour cell apoptosis	13
Microglia in retinal angiogenesis and diabetic retinopathy	13
Systemic glucocorticoids link to long-term microvascular injury in COVID-19	12
Notch1 and Notch4 core binding domain peptibodies exhibit distinct ligand-binding and anti-angiogenic properties	12
Lactate secreted by glycolytic conjunctival melanoma cells attracts and polarizes macrophages to drive angiogenesis in zebrafish xenografts	12
Opposite response of lung adenocarcinoma and its choroidal metastases upon ramucirumab plus docetaxel therapy after immunotherapy: a case report	12
Correction to: BI1 is associated with microvascular protection in cardiac ischemia reperfusion injury via repressing Syk-Nox2-Drp1-mitochondrial fission pathways	11
Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance	11
Plasma ratio of angiopoietin-2 to angiopoietin-1 is a biomarker of vascular impairment in chronic obstructive pulmonary disease patients	11
The modes of angiogenesis: an updated perspective	10
IC100, a humanized therapeutic monoclonal anti-ASC antibody alleviates oxygen-induced retinopathy in mice	10
The dynamics of the endothelial glycocalyx: a rare snapshot by electron microscopy	10
Correction: The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells	10
Pathological angiogenesis: mechanisms and therapeutic strategies	10
Evidence of premature vascular dysfunction in young adults who regularly use e-cigarettes and the impact of usage length	10
Timed topical dexamethasone eye drops improve mitochondrial function to prevent severe retinopathy of prematurity	9
Correction: Nectins and Nectin-like molecules drive vascular development and barrier function	9
A novel quantitative angiogenesis assay based on visualized vascular organoid	9
Study on mitogenic activity of serum from patients with total coronary occlusions: relation to duration of occlusion	9
Inflammation and vascular remodeling in COVID-19 hearts	9
Design and preclinical evaluation of a novel apelin-based PET radiotracer targeting APJ receptor for molecular imaging of angiogenesis	8
Phenotypic screening in Organ-on-a-Chip systems: a 1537 kinase inhibitor library screen on a 3D angiogenesis assay	8
Interferon-alpha or -beta facilitates SARS-CoV-2 pulmonary vascular infection by inducing ACE2	8
Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition	8
Somatic GJA4 gain-of-function mutation in orbital cavernous venous malformations	8
Damage to endothelial barriers and its contribution to long COVID	7
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE study	7
Anti-angiogenic therapy as potential treatment for adenomyosis	7
Human atherosclerotic plaque transcriptomics reveals endothelial beta-2 spectrin as a potential regulator a leaky plaque microvasculature phenotype	7

Circulating endothelial cells: a key biomarker of persistent fatigue after hospitalization for COVID-19	7
Protein disulfide isomerase A1 as a novel redox sensor in VEGFR2 signaling and angiogenesis	7
The vascularization paradox of non-union formation	7
Botulinum neurotoxin serotype A inhibited ocular angiogenesis through modulating glial activation via SOCS3	7
2022 14th HHT International Scientific Conference Abstracts	7