OOIR: Observatory of International Research

Papers

(The H4-Index of Neurobiology of Disease is 47. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier	316
Microglia and astrocyte dysfunction in parkinson's disease	182
Neuroprotection by dihydrotestosterone in LPS-induced neuroinflammation	113
Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis	106
Apolipoprotein E and oxidative stress in brain with relevance to Alzheimer's disease	100
How specific are the conformation-specific α-synuclein antibodies? Characterization and validation of 16 α-synuclein conformation-specific antibodies using well-characterized preparations of α-synucle	95
Long-lasting blood-brain barrier dysfunction and neuroinflammation after traumatic brain injury	95
Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system	83
Passive immunotherapies targeting Aβ and tau in Alzheimer's disease	81
Neuropathological evidence of body-first vs. brain-first Lewy body disease	79
Microglia depletion rapidly and reversibly alters amyloid pathology by modification of plaque compaction and morphologies	79
Genetic architecture of Alzheimer's disease	77
The wrinkling of time: Aging, inflammation, oxidative stress, and the circadian clock in neurodegeneration	77
Plasmalogens, platelet-activating factor and beyond – Ether lipids in signaling and neurodegeneration	74
CRISPR/dCas9-based Scn1a gene activation in inhibitory neurons ameliorates epileptic and behavioral phenotypes of Dravet syndrome model mice	71
Exosome-mediated delivery of antisense oligonucleotides targeting α-synuclein ameliorates the pathology in a mouse model of Parkinson's disease	70
Do Lewy bodies contain alpha-synuclein fibrils? and Does it matter? A brief history and critical analysis of recent reports	69
Oligomeric α-Syn and SNARE complex proteins in peripheral extracellular vesicles of neural origin are biomarkers for Parkinson's disease	69
Beyond the CNS: The many peripheral roles of APOE	68
It's complicated: The relationship between sleep and Alzheimer's disease in humans	67
APOE-amyloid interaction: Therapeutic targets	66
INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia	64
Shifting paradigms: The central role of microglia in Alzheimer's disease	60
Glia: victims or villains of the aging brain?	58
Obstructive Sleep Apnea and Its Treatment in Aging: Effects on Alzheimer’s disease Biomarkers, Cognition, Brain Structure and Neurophysiology	58

Clinical and imaging evidence of brain-first and body-first Parkinson's disease	57
Chronic stress induces formation of stress granules and pathological TDP-43 aggregates in human ALS fibroblasts and iPSC-motoneurons	56
The contribution of glial cells to Huntington's disease pathogenesis	56
Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response	56
An integrated metagenomics and metabolomics approach implicates the microbiota-gut-brain axis in the pathogenesis of Huntington's disease	54
Systematic review and meta-analysis of human transcriptomics reveals neuroinflammation, deficient energy metabolism, and proteostasis failure across neurodegeneration	53
TDP-43 and Tau Oligomers in Alzheimer's Disease, Amyotrophic Lateral Sclerosis, and Frontotemporal Dementia	53
Local field potentials in Parkinson's disease: A frequency-based review	53
Glia in neurodegeneration: Drivers of disease or along for the ride?	52
Cilia, ciliopathies and hedgehog-related forebrain developmental disorders	52
Co-expression patterns of microglia markers Iba1, TMEM119 and P2RY12 in Alzheimer's disease	51
Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease	51
Disease progression and prognostic factors in multiple system atrophy: A prospective cohort study	51
Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer's Disease	50
The genetic architecture of ALS	50
Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation	50
Single-cell RNA-seq analysis of the brainstem of mutant SOD1 mice reveals perturbed cell types and pathways of amyotrophic lateral sclerosis	49
SARS-CoV-2 deregulates the vascular and immune functions of brain pericytes via Spike protein	47
Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease	47
Multielectrode array analysis of EEG biomarkers in a mouse model of Fragile X Syndrome	47
Longitudinal degeneration of the basal forebrain predicts subsequent dementia in Parkinson's disease	47
Primary motor cortex in Parkinson’s disease: Functional changes and opportunities for neurostimulation	47