OOIR: Observatory of International Research

Papers

(The median citation count of Cell Research is 25. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Interaction between microbiota and immunity in health and disease	1758
Ferroptosis: molecular mechanisms and health implications	1497
Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease	640
Immune checkpoint signaling and cancer immunotherapy	619
The future of cancer immunotherapy: microenvironment-targeting combinations	463
A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling	383
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy	373
AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells	353
SARS-CoV-2 infects human neural progenitor cells and brain organoids	253
SARS-CoV-2 spike protein interacts with and activates TLR41	222
Discriminating mild from critical COVID-19 by innate and adaptive immune single-cell profiling of bronchoalveolar lavages	216
RAB31 marks and controls an ESCRT-independent exosome pathway	216
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma	194
Metabolic signaling in T cells	192
Calreticulin and cancer	183
Infection with novel coronavirus (SARS-CoV-2) causes pneumonia in Rhesus macaques	166
Coinfection with influenza A virus enhances SARS-CoV-2 infectivity	164
The metabolite α-KG induces GSDMC-dependent pyroptosis through death receptor 6-activated caspase-8	152
Three-dimensional bioprinted glioblastoma microenvironments model cellular dependencies and immune interactions	150
SARS-CoV-2 Omicron variant is highly sensitive to molnupiravir, nirmatrelvir, and the combination	149
Transcriptional and epigenetic basis of Treg cell development and function: its genetic anomalies or variations in autoimmune diseases	149
863 genomes reveal the origin and domestication of chicken	140
Molecular subtyping and genomic profiling expand precision medicine in refractory metastatic triple-negative breast cancer: the FUTURE trial	136
Liquid–liquid phase separation by SARS-CoV-2 nucleocapsid protein and RNA	126
Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma	126

A novel receptor-binding domain (RBD)-based mRNA vaccine against SARS-CoV-2	123
Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines	120
Innate lymphoid cells control signaling circuits to regulate tissue-specific immunity	113
Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma	112
The basis of a more contagious 501Y.V1 variant of SARS-CoV-2	111
A COVID-19 mRNA vaccine encoding SARS-CoV-2 virus-like particles induces a strong antiviral-like immune response in mice	111
Old dogs, new trick: classic cancer therapies activate cGAS	109
Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome	104
Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2	99
SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target	98
Tissue-specific transcriptional imprinting and heterogeneity in human innate lymphoid cells revealed by full-length single-cell RNA-sequencing	97
The m6A methylome of SARS-CoV-2 in host cells	96
A cohort autopsy study defines COVID-19 systemic pathogenesis	94
Mining of epitopes on spike protein of SARS-CoV-2 from COVID-19 patients	93
Reconstruction of cell spatial organization from single-cell RNA sequencing data based on ligand-receptor mediated self-assembly	92
Mucus production stimulated by IFN-AhR signaling triggers hypoxia of COVID-19	91
Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer	91
Degradation of lipid droplets by chimeric autophagy-tethering compounds	89
25-Hydroxycholesterol is a potent SARS-CoV-2 inhibitor	88
Reduced interferon antagonism but similar drug sensitivity in Omicron variant compared to Delta variant of SARS-CoV-2 isolates	88
Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain	86
Kinetics and mechanisms of mitotic inheritance of DNA methylation and their roles in aging-associated methylome deterioration	84
Single-cell transcriptomic atlas of primate cardiopulmonary aging	83
Dalbavancin binds ACE2 to block its interaction with SARS-CoV-2 spike protein and is effective in inhibiting SARS-CoV-2 infection in animal models	80
Molecular basis for ligand activation of the human KCNQ2 channel	80
The SARS-CoV-2 spike protein: balancing stability and infectivity	80
Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2	78
Cryo-EM structures of inactive and active GABAB receptor	76
High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing	75
Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms	75
Structural basis for nucleosome-mediated inhibition of cGAS activity	75
Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and Variants of Concern	74
A phosphatidic acid-binding lncRNA SNHG9 facilitates LATS1 liquid–liquid phase separation to promote oncogenic YAP signaling	73
Engineered trimeric ACE2 binds viral spike protein and locks it in “Three-up” conformation to potently inhibit SARS-CoV-2 infection	73
Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2	72
Structure-based development of human antibody cocktails against SARS-CoV-2	72
Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection	72
SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs	71
Enhancing prime editing by Csy4-mediated processing of pegRNA	71
Humoral immunogenicity and reactogenicity of CoronaVac or ZF2001 booster after two doses of inactivated vaccine	68
Resolving individual atoms of protein complex by cryo-electron microscopy	68
Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells	67
O-glycosylation pattern of the SARS-CoV-2 spike protein reveals an “O-Follow-N” rule	67
Wnt signaling and Loxl2 promote aggressive osteosarcoma	67
Dysregulated adaptive immune response contributes to severe COVID-19	66
Neddylation of PTEN regulates its nuclear import and promotes tumor development	65
Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR	64
Pericytes augment glioblastoma cell resistance to temozolomide through CCL5-CCR5 paracrine signaling	63
Genome-scale profiling of circulating cell-free DNA signatures for early detection of hepatocellular carcinoma in cirrhotic patients	63
A novel somatosensory spatial navigation system outside the hippocampal formation	62

Pulmonary alveolar regeneration in adult COVID-19 patients	62
Stabilization of heterochromatin by CLOCK promotes stem cell rejuvenation and cartilage regeneration	62
SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation	62
Comparative analysis of cell lineage differentiation during hepatogenesis in humans and mice at the single-cell transcriptome level	59
Predicting dynamic cellular protein–RNA interactions by deep learning using in vivo RNA structures	59
A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs	58
A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection	58
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics	57
Mechanisms of Polycomb group protein function in cancer	57
Time of day influences immune response to an inactivated vaccine against SARS-CoV-2	57
Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis	55
Distinct stem/progenitor cells proliferate to regenerate the trachea, intrapulmonary airways and alveoli in COVID-19 patients	55
An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments	55
Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition	54
Formative pluripotent stem cells show features of epiblast cells poised for gastrulation	54
A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor	52
Structural basis of human α7 nicotinic acetylcholine receptor activation	52
Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies	52
Comparison of viral RNA–host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2	52
Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses	51
Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle	51
Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration	51
RNA m6A modification orchestrates a LINE-1–host interaction that facilitates retrotransposition and contributes to long gene vulnerability	51
Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics	51
Molecular architecture of the luminal ring of the Xenopus laevis nuclear pore complex	51
Establishment of intestinal organoid cultures modeling injury-associated epithelial regeneration	50
Structural mechanism of cooperative activation of the human calcium-sensing receptor by Ca2+ ions and L-tryptophan	50
Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis	50
Mechanism of dopamine binding and allosteric modulation of the human D1 dopamine receptor	50
Cryo-EM structure of the human mitochondrial translocase TIM22 complex	49
USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity	48
Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells	48
Structural mechanism of phospholipids translocation by MlaFEDB complex	47
Interferon-armed RBD dimer enhances the immunogenicity of RBD for sterilizing immunity against SARS-CoV-2	46
Generation and characterization of stable pig pregastrulation epiblast stem cell lines	44
An exosome pathway without an ESCRT	43
Genome-wide high-resolution mapping of mitotic DNA synthesis sites and common fragile sites by direct sequencing	42
Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma	42
Structures of active melanocortin-4 receptor–Gs-protein complexes with NDP-α-MSH and setmelanotide	39
Tumor-conditional IL-15 pro-cytokine reactivates anti-tumor immunity with limited toxicity	38
CaMKIIα-driven, phosphatase-checked postsynaptic plasticity via phase separation	38
Merging PROTAC and molecular glue for degrading BTK and GSPT1 proteins concurrently	38
LRP6 downregulation promotes cardiomyocyte proliferation and heart regeneration	38
Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation	38
COPII mitigates ER stress by promoting formation of ER whorls	37
Molecular basis of ligand recognition and activation of human V2 vasopressin receptor	37
Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor	37
Publisher Correction: SARS-CoV-2 spike protein interacts with and activates TLR4	35
Structural insights into secretory immunoglobulin A and its interaction with a pneumococcal adhesin	35
Heterogeneity in endothelial cells and widespread venous arterialization during early vascular development in mammals	34
A virus-induced conformational switch of STAT1-STAT2 dimers boosts antiviral defenses	34
A distinct D1-MSN subpopulation down-regulates dopamine to promote negative emotional state	34
Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation	34
Peptide-based pan-CoV fusion inhibitors maintain high potency against SARS-CoV-2 Omicron variant	33
Active RNA interference in mitochondria	33
Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters	32
Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury	32
Structures of SARS-CoV-2 B.1.351 neutralizing antibodies provide insights into cocktail design against concerning variants	32
Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation	31
Mechanical activation of spike fosters SARS-CoV-2 viral infection	31
Rapid development of an updated mRNA vaccine against the SARS-CoV-2 Omicron variant	30
Structural insights into ligand recognition and activation of the melanocortin-4 receptor	29
Dissecting the epigenomic dynamics of human fetal germ cell development at single-cell resolution	29
Structure of the mitochondrial TIM22 complex from yeast	28
Structural basis of ALMT1-mediated aluminum resistance in Arabidopsis	28
Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3–Gi signaling complexes	28
Aldolase is a sensor for both low and high glucose, linking to AMPK and mTORC1	28
A new type of ERGIC–ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis	28
Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans	28
Structural insights into the activation of GLP-1R by a small molecule agonist	27
Association of assisted reproductive technology, germline de novo mutations and congenital heart defects in a prospective birth cohort study	26
Ferroptosis: the Good, the Bad and the Ugly	26
Structural insights into the membrane microdomain organization by SPFH family proteins	26
Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms	25
Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells	25
Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric Gs	25
The ChinaMAP reference panel for the accurate genotype imputation in Chinese populations	25
Mispair-bound human MutS–MutL complex triggers DNA incisions and activates mismatch repair	25
Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2	25