World Journal of Gastroenterology

Article	Citations
Pancreatic cancer: A review of epidemiology, trend, and risk factors	203
Gut microbiota in obesity	170
Molecular mechanisms of viral hepatitis induced hepatocellular carcinoma	131
Epidemiology of stomach cancer	121
Gastrointestinal and hepatic manifestations of COVID-19: A comprehensive review	117
COVID-19 pandemic: Pathophysiology and manifestations from the gastrointestinal tract	117
Liver diseases in COVID-19: Etiology, treatment and prognosis	101
Hepatocellular carcinoma in viral and autoimmune liver diseases: Role of CD4+ CD25+ Foxp3+ regulatory T cells in the immune microenvironment	101
Role of gut microbiota on intestinal barrier function in acute pancreatitis	100
Pancreatic neuroendocrine tumors: A review of serum biomarkers, staging, and management	91
Gut microbiota, inflammatory bowel disease and colorectal cancer	90
Hepatitis E virus: Epidemiology, diagnosis, clinical manifestations, and treatment	88
Role of gut microbiota via the gut-liver-brain axis in digestive diseases	78
Watch and wait approach in rectal cancer: Current controversies and future directions	74
Gut microbiome in primary sclerosing cholangitis: A review	74
Artificial intelligence in gastric cancer: Application and future perspectives	73
Update on the applications and limitations of alpha-fetoprotein for hepatocellular carcinoma	68
Metabolic inflammation as an instigator of fibrosis during non-alcoholic fatty liver disease	66
Artificial intelligence applications in inflammatory bowel disease: Emerging technologies and future directions	63
Altered profiles of fecal bile acids correlate with gut microbiota and inflammatory responses in patients with ulcerative colitis	62
Helicobacter pylori infection: Beyond gastric manifestations	62
Pancreatic cancer in 2021: What you need to know to win	61
Transjugular intrahepatic portosystemic shunt in cirrhosis: An exhaustive critical update	60
Current guidelines for the management of celiac disease: A systematic review with comparative analysis	60
High prevalence of hepatic steatosis and vascular thrombosis in COVID-19: A systematic review and meta-analysis of autopsy data	59

Management of cholelithiasis with choledocholithiasis: Endoscopic and surgical approaches	55
Immune checkpoint inhibitor-related hepatotoxicity: A review	53
COVID-19 pandemic: Its impact on liver disease and liver transplantation	53
From hepatitis A to E: A critical review of viral hepatitis	53
Benign gallbladder diseases: Imaging techniques and tips for differentiating with malignant gallbladder diseases	53
Helicobacter pylori: Commensal, symbiont or pathogen?	52
Etiology and management of liver injury in patients with COVID-19	52
Artificial intelligence in gastroenterology: A state-of-the-art review	52
Differential regulation of JAK/STAT-signaling in patients with ulcerative colitis and Crohn’s disease	50
Clinical efficacy of the over-the-scope clip device: A systematic review	49
Chinese guidelines on the management of liver cirrhosis (abbreviated version)	48
Endoscopic management of gastrointestinal leaks and fistulae: What option do we have?	48
Liver injury in the era of COVID-19	46
Prediction of clinically actionable genetic alterations from colorectal cancer histopathology images using deep learning	46
Effect of probiotic Lactobacillus plantarum Dad-13 powder consumption on the gut microbiota and intestinal health of overweight adults	46
Shared decision-making in the management of patients with inflammatory bowel disease	45
Gastroparesis: New insights into an old disease	44
Altered metabolism of bile acids correlates with clinical parameters and the gut microbiota in patients with diarrhea-predominant irritable bowel syndrome	44
Lactobacillus bulgaricus inhibits colitis-associated cancer via a negative regulation of intestinal inflammation in azoxymethane/dextran sodium sulfate model	43
Oral microbiome and pancreatic cancer	43
Construction of a convolutional neural network classifier developed by computed tomography images for pancreatic cancer diagnosis	43
Effect of berberine on hyperglycaemia and gut microbiota composition in type 2 diabetic Goto-Kakizaki rats	43
Artificial intelligence in the diagnosis and management of colorectal cancer liver metastases	43
BRCA mutated pancreatic cancer: A change is coming	43
Antimicrobial peptides and the gut microbiome in inflammatory bowel disease	42
Consensus on the definition of colorectal anastomotic leakage: A modified Delphi study	42
Fecal microbiota transplantation ameliorates experimental colitis via gut microbiota and T-cell modulation	42
Cirrhotic portal hypertension: From pathophysiology to novel therapeutics	41
Machine learning models and over-fitting considerations	41
Potential of the ellagic acid-derived gut microbiota metabolite – Urolithin A in gastrointestinal protection	40
Sarcopenia in hepatocellular carcinoma: Current knowledge and future directions	40
Biomarkers in the diagnosis of pancreatic cancer: Are we closer to finding the golden ticket?	40
Diet in neurogenic bowel management: A viewpoint on spinal cord injury	40
Multi-modal radiomics model to predict treatment response to neoadjuvant chemotherapy for locally advanced rectal cancer	40
Secondary causes of inflammatory bowel diseases	40
Early-onset colorectal cancer: A review of current knowledge	40
Molecular overview of progressive familial intrahepatic cholestasis	40
Gut bless you: The microbiota-gut-brain axis in irritable bowel syndrome	39
Metastatic pattern in esophageal and gastric cancer: Influenced by site and histology	38
Ever-increasing diversity of drug-induced pancreatitis	38
Pathophysiological mechanisms underlying gastrointestinal symptoms in patients with COVID-19	38
Application of artificial intelligence in the diagnosis and treatment of hepatocellular carcinoma: A review	38
Artificial intelligence based real-time microcirculation analysis system for laparoscopic colorectal surgery	38
Viral hepatitis update: Progress and perspectives	37
New strain of Pediococcus pentosaceus alleviates ethanol-induced liver injury by modulating the gut microbiota and short-chain fatty acid metabolism	37
Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives	37
Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions	37
Radiomics and machine learning applications in rectal cancer: Current update and future perspectives	36
Endoscopic diagnosis and treatment of gastric dysplasia and early cancer: Current evidence and what the future may hold	36
Practical review for diagnosis and clinical management of perihilar cholangiocarcinoma	36

Interventions of natural and synthetic agents in inflammatory bowel disease, modulation of nitric oxide pathways	36
Prognostic role of artificial intelligence among patients with hepatocellular cancer: A systematic review	36
Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review	35
Role of long noncoding RNA-mediated competing endogenous RNA regulatory network in hepatocellular carcinoma	35
COVID-19-associated diarrhea	35
Gut microbiota in various childhood disorders: Implication and indications	35
Prevention of vertical transmission of hepatitis B virus infection	35
Resveratrol alleviates intestinal mucosal barrier dysfunction in dextran sulfate sodium-induced colitis mice by enhancing autophagy	34
Artificial intelligence-assisted colonoscopy: A review of current state of practice and research	34
COVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms	34
Impaired coagulation, liver dysfunction and COVID-19: Discovering an intriguing relationship	34
Impact of mobile health and medical applications on clinical practice in gastroenterology	33
Association between non-alcoholic fatty liver disease and obstructive sleep apnea	33
Efficacy and safety of lenvatinib for patients with advanced hepatocellular carcinoma: A retrospective, real-world study conducted in China	33
Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease	33
Long noncoding RNAs in gastric cancer: From molecular dissection to clinical application	33
Relationship between clinical features and intestinal microbiota in Chinese patients with ulcerative colitis	33
Diabetes and pancreatic cancer: Exploring the two-way traffic	33
Gut microbiome composition can predict the response to nivolumab in advanced hepatocellular carcinoma patients	33
Clinical assessment and management of liver fibrosis in non-alcoholic fatty liver disease	32
COVID-19 and the gastrointestinal tract: source of infection or merely a target of the inflammatory process following SARS-CoV-2 infection?	32
Ursodeoxycholic acid as a means of preventing atherosclerosis, steatosis and liver fibrosis in patients with nonalcoholic fatty liver disease	32
Intratumoral heterogeneity of hepatocellular carcinoma: From single-cell to population-based studies	31
Risk prediction platform for pancreatic fistula after pancreatoduodenectomy using artificial intelligence	31
Non-alcoholic fatty liver disease and hepatocellular carcinoma: Clinical challenges of an intriguing link	31
T cells in pancreatic cancer stroma	30
Monocyte-to-lymphocyte ratio as a prognostic factor in peripheral whole blood samples of colorectal cancer patients	30
Imaging-based algorithmic approach to gallbladder wall thickening	30
Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy	30
Metabolomics profile in gastrointestinal cancers: Update and future perspectives	30
Metabolic complications of hepatitis C virus infection	29
Mucosal lesions of the upper gastrointestinal tract in patients with ulcerative colitis: A review	29
Update on the management of sigmoid diverticulitis	29
Alteration of fecal tryptophan metabolism correlates with shifted microbiota and may be involved in pathogenesis of colorectal cancer	29
Viral hepatitis: Past, present, and future	29
Role of bile acids in liver diseases mediated by the gut microbiome	29
Artificial intelligence-assisted esophageal cancer management: Now and future	28
Gastrinoma and Zollinger Ellison syndrome: A roadmap for the management between new and old therapies	28
Acute gastrointestinal injury in critically ill patients with COVID-19 in Wuhan, China	28
Pancreatic neuroendocrine tumors: Therapeutic challenges and research limitations	28
Invasive fungal infection before and after liver transplantation	28
Golgi protein-73: A biomarker for assessing cirrhosis and prognosis of liver disease patients	28
Toward a new era of hepatitis B virus therapeutics: The pursuit of a functional cure	28
Can control of gut microbiota be a future therapeutic option for inflammatory bowel disease?	28
Predictors of early and late hepatocellular carcinoma recurrence	28
Updates on global epidemiology, risk and prognostic factors of gastric cancer	27
How to manage inflammatory bowel disease during the COVID-19 pandemic: A guide for the practicing clinician	27
Review of primary sclerosing cholangitis with increased IgG4 levels	27
Multiphase convolutional dense network for the classification of focal liver lesions on dynamic contrast-enhanced computed tomography	27
Antioxidant activity and hepatoprotective effect of 10 medicinal herbs on CCl4-induced liver injury in mice	27
Microbiota revolution: How gut microbes regulate our lives	27
Endoscopic submucosal dissection vs endoscopic mucosal resection for colorectal polyps: A meta-analysis and meta-regression with single arm analysis	27
Local ablation of pancreatic tumors: State of the art and future perspectives	27
Determination of gluten immunogenic peptides for the management of the treatment adherence of celiac disease: A systematic review	27
Exosomal microRNA-588 from M2 polarized macrophages contributes to cisplatin resistance of gastric cancer cells	26
G protein-coupled receptors as potential targets for nonalcoholic fatty liver disease treatment	26
Non-invasive tests for the prediction of primary hepatocellular carcinoma	26
Nutrition in alcohol-related liver disease: Physiopathology and management	26
Quercetin exerts anti-inflammatory effects via inhibiting tumor necrosis factor-α-induced matrix metalloproteinase-9 expression in normal human gastric epithelial cells	26
Risk of malignancy in Caroli disease and syndrome: A systematic review	26
Potential applications of artificial intelligence in colorectal polyps and cancer: Recent advances and prospects	26
Neuromechanism of acupuncture regulating gastrointestinal motility	26
Use of artificial intelligence in improving adenoma detection rate during colonoscopy: Might both endoscopists and pathologists be further helped	26
Ultrasound liver elastography beyond liver fibrosis assessment	26
Quantitative multiparametric magnetic resonance imaging can aid non-alcoholic steatohepatitis diagnosis in a Japanese cohort	26
Advances in traction methods for endoscopic submucosal dissection: What is the best traction method and traction direction?	26
Update on the management and treatment of viral hepatitis	26
Gegen Qinlian decoction enhances immunity and protects intestinal barrier function in colorectal cancer patients via gut microbiota	26
Hepatocellular carcinoma after direct-acting antiviral hepatitis C virus therapy: A debate near the end	26
Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art	25
Identification of differentially expressed genes in ulcerative colitis and verification in a colitis mouse model by bioinformatics analyses	25
Interaction between hepatitis B virus and SARS-CoV-2 infections	25
Review of inflammatory bowel disease and COVID-19	25
Therapeutic resistance in pancreatic ductal adenocarcinoma: Current challenges and future opportunities	25
Folic acid attenuates high-fat diet-induced steatohepatitis via deacetylase SIRT1-dependent restoration of PPARα	25
Annexin A2 promotion of hepatocellular carcinoma tumorigenesis via the immune microenvironment	25
Hepatocellular carcinoma locoregional therapies: Outcomes and future horizons	25
Medical management of metabolic and cardiovascular complications after liver transplantation	25
Gastrointestinal complications after kidney transplantation	25
International patterns in incidence and mortality trends of pancreatic cancer in the last three decades: A joinpoint regression analysis	25

Gut microbiome in acute pancreatitis: A review based on current literature	25
Acute liver failure and death predictors in patients with dengue-induced severe hepatitis	24
Fusobacterium nucleatum colonization is associated with decreased survival of helicobacter pylori-positive gastric cancer patients	24
Abdominal and gastrointestinal manifestations in COVID-19 patients: Is imaging useful?	24
Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis	24
Prediction of different stages of rectal cancer: Texture analysis based on diffusion-weighted images and apparent diffusion coefficient maps	24
Successful robotic radical resection of hepatic echinococcosis located in posterosuperior liver segments	24
Novel drug delivery systems for inflammatory bowel disease	24
Human hepatitis viruses-associated cutaneous and systemic vasculitis	24
Nuclear factor erythroid 2-related factor 2-mediated signaling and metabolic associated fatty liver disease	24
Effects of sepsis and its treatment measures on intestinal flora structure in critical care patients	24
Efficacy and safety of anti-hepatic fibrosis drugs	23
Liver dysfunction and SARS-CoV-2 infection	23
Impact of Helicobacter pylori infection on gut microbiota	23
Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients	23
Celiac disease: From genetics to epigenetics	23
Combining protein arginine methyltransferase inhibitor and anti-programmed death-ligand-1 inhibits pancreatic cancer progression	23
Use of zebrafish embryos as avatar of patients with pancreatic cancer: A new xenotransplantation model towards personalized medicine	23
Challenges and opportunities in the application of artificial intelligence in gastroenterology and hepatology	23
Role of baicalin as a potential therapeutic agent in hepatobiliary and gastrointestinal disorders: A review	23
New advances in radiomics of gastrointestinal stromal tumors	23
Nonalcoholic fatty liver disease in lean subjects: Prognosis, outcomes and management	23
Celecoxib attenuates hepatocyte apoptosis by inhibiting endoplasmic reticulum stress in thioacetamide-induced cirrhotic rats	22
Current understanding of the metabolism of micronutrients in chronic alcoholic liver disease	22
Pancreatic adenocarcinoma: A review of recent paradigms and advances in epidemiology, clinical diagnosis and management	22
Short- and long-term outcomes associated with enhanced recovery after surgery protocol vs conventional management in patients undergoing laparoscopic gastrectomy	22
Chinese expert consensus on neoadjuvant and conversion therapies for hepatocellular carcinoma	22
Prevalence and risk factors of nonalcoholic fatty liver disease in patients with inflammatory bowel diseases: A cross-sectional and longitudinal analysis	22
Responses to faecal microbiota transplantation in female and male patients with irritable bowel syndrome	22
Viral hepatitis and hepatocellular carcinoma: From molecular pathways to the role of clinical surveillance and antiviral treatment	22
Non-alcoholic fatty liver and chronic kidney disease: Retrospect, introspect, and prospect	22
Role of gut microbiota-immunity axis in patients undergoing surgery for colorectal cancer: Focus on short and long-term outcomes	22
Immunotherapy for hepatocellular carcinoma: Current status and future perspectives	22
Paediatric gastrointestinal disorders in SARS-CoV-2 infection: Epidemiological and clinical implications	22
Antibiotics, gut microbiota, and irritable bowel syndrome: What are the relations?	22
Comparative study on artificial intelligence systems for detecting early esophageal squamous cell carcinoma between narrow-band and white-light imaging	22
Global research trends in the microbiome related to irritable bowel syndrome: A bibliometric and visualized study	22
Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus: An observational study	22
Validation of conventional non-invasive fibrosis scoring systems in patients with metabolic associated fatty liver disease	22
Development of a computed tomography-based radiomics nomogram for prediction of transarterial chemoembolization refractoriness in hepatocellular carcinoma	22
Gastrointestinal involvement in paediatric COVID-19 — from pathogenesis to clinical management: A comprehensive review	21
Systematic review of the prevalence and development of osteoporosis or low bone mineral density and its risk factors in patients with inflammatory bowel disease	21
Artificial intelligence technique in detection of early esophageal cancer	21
Periodontitis combined with smoking increases risk of the ulcerative colitis: A national cohort study	21
Gastrointestinal mucosal immunity and COVID-19	21
Microbiota shaping — the effects of probiotics, prebiotics, and fecal microbiota transplant on cognitive functions: A systematic review	21
Neurological and psychiatric effects of hepatitis C virus infection	21
Repurposing metformin for the treatment of gastrointestinal cancer	21
Role of γδT cells in liver diseases and its relationship with intestinal microbiota	21
Textbook outcomes in hepatobiliary and pancreatic surgery	21
Radiomics of rectal cancer for predicting distant metastasis and overall survival	21
Emerging use of artificial intelligence in inflammatory bowel disease	21
Acute kidney injury and hepatorenal syndrome in cirrhosis	21
Viral hepatitis: Milestones, unresolved issues, and future goals	21
Risk of hepatocellular carcinoma after hepatitis C virus cure	21
Endoscopic management of difficult common bile duct stones: Where are we now? A comprehensive review	21
Non-occlusive mesenteric ischemia: Diagnostic challenges and perspectives in the era of artificial intelligence	20
Current status of Helicobacter pylori eradication and risk factors for eradication failure	20
Can contrast enhanced ultrasound differentiate intrahepatic cholangiocarcinoma from hepatocellular carcinoma?	20
Gut mucosal microbiota profiles linked to colorectal cancer recurrence	20
New role for ceramide in hypoxia and insulin resistance	20
Chronic hepatitis B infection with concomitant hepatic steatosis: Current evidence and opinion	20
Epidemiology of perforating peptic ulcer: A population-based retrospective study over 40 years	20
Coronavirus disease–2019 and the intestinal tract: An overview	20
Potential risk factors for constipation in the community	20
Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care	20
Tumor microenvironment in primary liver tumors: A challenging role of natural killer cells	20
Gut microbiota mediated molecular events and therapy in liver diseases	20
High plasma levels of COL10A1 are associated with advanced tumor stage in gastric cancer patients	20
Changes in gut microbiota composition and diversity associated with post-cholecystectomy diarrhea	19
Gossip in the gut: Quorum sensing, a new player in the host-microbiota interactions	19
Hepatitis B virus infection and hepatocellular carcinoma in sub-Saharan Africa: Implications for elimination of viral hepatitis by 2030?	19
RBBP4 promotes colon cancer malignant progression via regulating Wnt/β-catenin pathway	19
Chronic intestinal failure and short bowel syndrome in Crohn’s disease	19
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation	19
Insufficient etiological workup of COVID-19-associated acute pancreatitis: A systematic review	19
Rectal neuroendocrine tumors: Current advances in management, treatment, and surveillance	19
Clinicopathological features of early gastric cancers arising in Helicobacter pylori uninfected patients	19
Artificial intelligence technologies for the detection of colorectal lesions: The future is now	19
Experimental models of metabolic and alcoholic fatty liver disease	19
Response of gut microbiota to serum metabolome changes in intrahepatic cholestasis of pregnant patients	19
MiR-301a transcriptionally activated by HIF-2α promotes hypoxia-induced epithelial-mesenchymal transition by targeting TP63 in pancreatic cancer	19
Autoimmune liver diseases in systemic rheumatic diseases	19
Clinical characteristics and outcomes of patients with hepatic angiomyolipoma: A literature review	18
Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus	18
Ischemic bowel disease in 2021	18
Treatment of gastrointestinal bleeding in left ventricular assist devices: A comprehensive review	18
Current understanding of the impact of COVID-19 on gastrointestinal disease: Challenges and openings	18
Neutrophil extracellular traps participate in the development of cancer-associated thrombosis in patients with gastric cancer	18
Promising xenograft animal model recapitulating the features of human pancreatic cancer	18
Percutaneous gastrostomy – Too often? Too late? Who are the right patients for gastrostomy?	18
Viscoelastic tests in liver disease: where do we stand now?	18
Overlooked risk for needle tract seeding following endoscopic ultrasound-guided minimally invasive tissue acquisition	18
Risk factors for lymph node metastasis in T1 esophageal squamous cell carcinoma: A systematic review and meta-analysis	18
Hepatitis E in solid organ transplant recipients: A systematic review and meta-analysis	18