OOIR: Observatory of International Research

Papers

(The TQCC of Inflammation Research is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
The coagulopathy, endotheliopathy, and vasculitis of COVID-19	294
The possible pathophysiology mechanism of cytokine storm in elderly adults with COVID-19 infection: the contribution of “inflame-aging”	191
Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome	179
Coronavirus (Covid-19) sepsis: revisiting mitochondrial dysfunction in pathogenesis, aging, inflammation, and mortality	113
Inflammasome formation in the lungs of patients with fatal COVID-19	100
Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin	82
Epigenetic signatures underlying inflammation: an interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition	75
Are the cutaneous manifestations during or due to SARS-CoV-2 infection/COVID-19 frequent or not? Revision of possible pathophysiologic mechanisms	73
Macrophage polarization in intestinal inflammation and gut homeostasis	60
The phase changes of M1/M2 phenotype of microglia/macrophage following oxygen-induced retinopathy in mice	55
The role of CD8 + T lymphocytes in chronic obstructive pulmonary disease: a systematic review	41
Quercetin alleviates neonatal hypoxic-ischemic brain injury by inhibiting microglia-derived oxidative stress and TLR4-mediated inflammation	40
Molecular mechanisms of ferroptosis and relevance to inflammation	40
Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis	40
RETRACTED ARTICLE: Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA-15a and repressing ROCK1 expression	38
SARS-CoV-2-mediated inflammatory response in lungs: should we look at RAGE?	37
The efficacy and safety of levilimab in severely ill COVID-19 patients not requiring mechanical ventilation: results of a multicenter randomized double-blind placebo-controlled phase III CORONA clinic	37
Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases	37
COVID-19 disrupts the blood–testis barrier through the induction of inflammatory cytokines and disruption of junctional proteins	35
Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis	33
CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis	32
Histamine receptors and COVID-19	32
Targeting JAK/STAT signaling pathways in treatment of inflammatory bowel disease	31
The role of interferon-γ in cardiovascular disease: an update	31
The RNA-binding protein SND1 promotes the degradation of GPX4 by destabilizing the HSPA5 mRNA and suppressing HSPA5 expression, promoting ferroptosis in osteoarthritis chondrocytes	30

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19	30
H. pylori CagA activates the NLRP3 inflammasome to promote gastric cancer cell migration and invasion	30
TAB1 regulates glycolysis and activation of macrophages in diabetic nephropathy	30
Colchicine for COVID-19: targeting NLRP3 inflammasome to blunt hyperinflammation	29
Sepsis-induced myocardial dysfunction: the role of mitochondrial dysfunction	29
Inflammasome activation in podocytes: a new mechanism of glomerular diseases	29
The protective effects of phoenixin-14 against lipopolysaccharide-induced inflammation and inflammasome activation in astrocytes	29
Notch signaling pathway in infectious diseases: role in the regulation of immune response	28
Metabolic reprogramming as a key regulator in the pathogenesis of rheumatoid arthritis	27
Therapeutic implications of cyclooxygenase (COX) inhibitors in ischemic injury	27
Adverse Ocular Events following COVID-19 Vaccination	27
Transcriptomic analysis of hidradenitis suppurativa skin suggests roles for multiple inflammatory pathways in disease pathogenesis	25
Particulate matter in COPD pathogenesis: an overview	25
Gisenoside Rg1 attenuates cadmium-induced neurotoxicity in vitro and in vivo by attenuating oxidative stress and inflammation	25
Intercellular communication and ion channels in neuropathic pain chronicization	25
Acute reduction of visual acuity and visual field after Pfizer-BioNTech COVID-19 vaccine 2nd dose: a case report	25
IL-33 enhances macrophage release of IL-1β and promotes pain and inflammation in gouty arthritis	24
Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies	23
TREM-1 aggravates chronic obstructive pulmonary disease development via activation NLRP3 inflammasome-mediated pyroptosis	22
SARS-CoV-2 and pathological matrix remodeling mediators	21
Potential of anthocyanin as an anti-inflammatory agent: a human clinical trial on type 2 diabetic, diabetic at-risk and healthy adults	21
Dexmedetomidine exerts cerebral protective effects against cerebral ischemic injury by promoting the polarization of M2 microglia via the Nrf2/HO-1/NLRP3 pathway	21
Role of the innate and adaptive immune responses in the pathogenesis of systemic lupus erythematosus	21
The role of lung macrophages in acute respiratory distress syndrome	21
Long-term implications of COVID-19 on bone health: pathophysiology and therapeutics	20
SARS-CoV-2 will constantly sweep its tracks: a vaccine containing CpG motifs in ‘lasso’ for the multi-faced virus	20
Upregulation of endothelial cell-derived exosomal microRNA-125b-5p protects from sepsis-induced acute lung injury by inhibiting topoisomerase II alpha	20
Potential roles of mitochondrial cofactors in the adjuvant mitigation of proinflammatory acute infections, as in the case of sepsis and COVID-19 pneumonia	19
Methyl gallate attenuates inflammation induced by Toll-like receptor ligands by inhibiting MAPK and NF-Κb signaling pathways	19
The unleashing of the immune system in COVID-19 and sepsis: the calm before the storm?	19
A case of reactivation of varicella–zoster virus after BNT162b2 vaccine second dose?	19
Uric acid drives intestinal barrier dysfunction through TSPO-mediated NLRP3 inflammasome activation	18
Luteolin alleviates ulcerative colitis through SHP-1/STAT3 pathway	18
Burn injury induces elevated inflammatory traffic: the role of NF-κB	18
Targeting a novel hsa_circ_0000520/miR-556-5p/NLRP3 pathway-mediated cell pyroptosis and inflammation attenuates ovalbumin (OVA)-induced allergic rhinitis (AR) in mice models	18
Neuroinflammatory mediators in acquired epilepsy: an update	18
FOXO3a regulates lipid accumulation and adipocyte inflammation in adipocytes through autophagy	18
Jumonji domain containing-3 (JMJD3) inhibition attenuates IL-1β-induced chondrocytes damage in vitro and protects osteoarthritis cartilage in vivo	17
Macrophage ICAM-1 functions as a regulator of phagocytosis in LPS induced endotoxemia	17
Role of α-synuclein in microglia: autophagy and phagocytosis balance neuroinflammation in Parkinson’s disease	17
Severity of SARS-CoV-2 infection is linked to double-negative (CD27− IgD−) B cell subset numbers	17
Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy	17
Synergistic anti-inflammatory effect of gut microbiota and lithocholic acid on liver fibrosis	17
Fenofibrate for COVID-19 and related complications as an approach to improve treatment outcomes: the missed key for Holy Grail	16
Significance of glutathione peroxidase 4 and intracellular iron level in ovarian cancer cells—“utilization” of ferroptosis mechanism	16
Anti-inflammatory latex proteins of the medicinal plant Calotropis procera: a promising alternative for oral mucositis treatment	16
Chronic inflammation and long-lasting changes in the gastric mucosa after Helicobacter pylori infection involved in gastric cancer	16
Changes of lipoxin levels during pregnancy and the monthly-cycle, condition the normal course of pregnancy or pathology	16
Circulating levels of calprotectin, a signature of neutrophil activation in prediction of severe respiratory failure in COVID-19 patients: a multicenter, prospective study (CalCov study)	16
IL-33 deficiency protects mice from DSS-induced experimental colitis by suppressing ILC2 and Th17 cell responses	16

Elevated systemic immune inflammation level increases the risk of total and cause-specific mortality among patients with chronic kidney disease: a large multi-center longitudinal study	16
A role for mast cells and mast cell tryptase in driving neutrophil recruitment in LPS-induced lung inflammation via protease-activated receptor 2 in mice	16
A20 attenuates pyroptosis and apoptosis in nucleus pulposus cells via promoting mitophagy and stabilizing mitochondrial dynamics	16
CD20+ T cells: an emerging T cell subset in human pathology	15
MicroRNA-199-3p up-regulation enhances chondrocyte proliferation and inhibits apoptosis in knee osteoarthritis via DNMT3A repression	15
Dihydroartemisinin alleviates AngII-induced vascular smooth muscle cell proliferation and inflammatory response by blocking the FTO/NR4A3 axis	14
Immunoglobulin free light chains: an inflammatory biomarker of diabetes	14
Bone marrow mesenchymal stem cells-derived exosomes containing miR-539-5p inhibit pyroptosis through NLRP3/caspase-1 signalling to alleviate inflammatory bowel disease	14
Activation of the STING pathway induces peripheral sensitization via neuroinflammation in a rat model of bone cancer pain	13
RETRACTED ARTICLE: Tripterine ameliorates monosodium urate crystal-induced gouty arthritis by altering macrophage polarization via the miR-449a/NLRP3 axis	13
Silencing circANKRD36 inhibits streptozotocin-induced insulin resistance and inflammation in diabetic rats by targeting miR-145 via XBP1	13
RPL38 knockdown inhibits the inflammation and apoptosis in chondrocytes through regulating METTL3-mediated SOCS2 m6A modification in osteoarthritis	13
Regulation of Toll-like receptor-mediated inflammatory response by microRNA-152-3p-mediated demethylation of MyD88 in systemic lupus erythematosus	13
Impaired salivary SIgA antibodies elicit oral dysbiosis and subsequent induction of alveolar bone loss	13
The role of NK cells in rheumatoid arthritis	13
FSTL1 aggravates OVA-induced inflammatory responses by activating the NLRP3/IL-1β signaling pathway in mice and macrophages	12
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia–reperfusion injury	12
Cysteinyl leukotriene D4 (LTD4) promotes airway epithelial cell inflammation and remodelling	12
Comprehensive comparison of the prognostic value of systemic inflammation biomarkers for cancer cachexia: a multicenter prospective study	12
Association of interleukin 6 -174 G/C polymorphism with coronary artery disease and circulating IL-6 levels: a systematic review and meta-analysis	12
The role of 5-lipoxygenase in the pathophysiology of COVID-19 and its therapeutic implications	12
Immunosenescence of T cells: a key player in rheumatoid arthritis	12
LncRNA MBLN1-AS1 inhibits the progression of retinoblastoma through targeting miR-338-5p-Wnt/β-catenin signaling pathway	12
The prognostic value of S100A calcium binding protein family members in predicting severe forms of COVID-19	12
Neutrophils as emerging protagonists and targets in chronic inflammatory diseases	12
MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer	11
COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines	11
Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury	11
Pregnancy tailors endotoxin-induced monocyte and neutrophil responses in the maternal circulation	11
Local IL-17 positive T cells are functionally associated with neutrophil infiltration and their development is regulated by mucosal microenvironment in nasal polyps	11
Gut microbiome, Vitamin D, ACE2 interactions are critical factors in immune-senescence and inflammaging: key for vaccine response and severity of COVID-19 infection	11
COVID-19 illness and autoimmune diseases: recent insights	11
NORAD lentivirus shRNA mitigates fibrosis and inflammatory responses in diabetic cardiomyopathy via the ceRNA network of NORAD/miR-125a-3p/Fyn	11
The pathophysiology of immunoporosis: innovative therapeutic targets	11
PIM1 inhibition attenuated endotoxin-induced acute lung injury through modulating ELK3/ICAM1 axis on pulmonary microvascular endothelial cells	11
Protocatechuic acid supplement alleviates allergic airway inflammation by inhibiting the IL-4Rα–STAT6 and Jagged 1/Jagged2–Notch1/Notch2 pathways in allergic asthmatic mice	11
The expression levels of CHI3L1 and IL15Rα correlate with TGM2 in duodenum biopsies of patients with celiac disease	11
Emerging perspectives on mitochondrial dysfunctioning and inflammation in epileptogenesis	10
Blockade of macrophage-associated programmed death 1 inhibits the pyroptosis signalling pathway in sepsis	10
Fertility and infertility implications in rheumatoid arthritis; state of the art	10
Sublingual immunotherapy for 4 years increased the number of Foxp3+ Treg cells, which correlated with clinical effects	10
MiR-21 participates in LPS-induced myocardial injury by targeting Bcl-2 and CDK6	10
Mast cells and angiogenesis in multiple sclerosis	10
Cellular and molecular events of inflammation induced transdifferentiation (EMT) and regeneration (MET) in mesenteric mesothelial cells	10
How could perfluorocarbon affect cytokine storm and angiogenesis in coronavirus disease 2019 (COVID-19): role of hypoxia-inducible factor 1α	10
Increased miR-124-3p alleviates type 2 inflammatory response in allergic rhinitis via IL-4Rα	10
S14G-humanin (HNG) protects retinal endothelial cells from UV-B-induced NLRP3 inflammation activation through inhibiting Egr-1	10
Activated M1 macrophages suppress c-kit expression via TNF-α-mediated upregulation of miR-222 in Neonatal Necrotizing Enterocolitis	10
Ethyl pyruvate, a versatile protector in inflammation and autoimmunity	9
An apoptosis inhibitor suppresses microglial and astrocytic activation after cardiac ischemia/reperfusion injury	9
gga-miR-142-3p negatively regulates Mycoplasma gallisepticum (HS strain)-induced inflammatory cytokine production via the NF-κB and MAPK signaling by targeting TAB2	9
The effect of immunomodulatory properties of naringenin on the inhibition of inflammation and oxidative stress in autoimmune disease models: a systematic review and meta-analysis of preclinical eviden	9
The role of Th17 cells: explanation of relationship between periodontitis and COPD?	9
Inhibition of visfatin alleviates sepsis-induced intestinal damage by inhibiting Hippo signaling pathway	9
Association between IL-17A, IL-17F and IL-17RA gene polymorphisms and susceptibility to psoriasis and psoriatic arthritis: a meta-analysis	9
An antagonist of growth hormone-releasing hormone protects against LPS-induced increase of bronchoalveolar lavage fluid protein concentration	9
Manifestation of lipopolysaccharide-induced tolerance in neuro-glial primary cultures of the rat afferent somatosensory system	9
Inflammatory biomarkers in staging of chronic kidney disease: elevated TNFR2 levels accompanies renal function decline	9
Osteoarthritic infrapatellar fat pad aggravates cartilage degradation via activation of p38MAPK and ERK1/2 pathways	9