OOIR: Observatory of International Research

Papers

(The TQCC of Inflammation Research is 11. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
News	240
Loss of TRIM24 promotes IL-10 expression via CBP/p300-dependent IFNβ1 transcription during macrophage activation	178
CHRFAM7A expression in mice increases resiliency after injury	141
IL10/AMPK pathway was associated with the hippocampal anti-inflammatory response to high-sugar and high-fat diet withdrawal	68
Long-chain acyl-CoA synthetase 4-mediated mitochondrial fatty acid metabolism and dendritic cell antigen presentation	64
Mitochondrial damage causes inflammation via cGAS-STING signaling in ketamine-induced cystitis	61
Tissue-resident immune cells in the pathogenesis of multiple sclerosis	58
Beyond CYP2C19: inflammation and angiogenesis gene variants drive clopidogrel resistance in CAD patients	57
The role of fatty acid metabolism on B cells and B cell-related autoimmune diseases	56
Clinical outcomes of anti-inflammatory therapies inhibiting the NLRP3/IL-1β/IL-6/CRP pathway in coronary artery disease patients: a systemic review and meta-analysis of 37,056 individuals from 32 rand	56
Viperin deficiency promotes dendritic cell activation and function via NF-kappaB activation during Mycobacterium tuberculosis infection	55
IL-33, a neutrophil extracellular trap-related gene involved in the progression of diabetic kidney disease	52
Correction to: Circulating calprotectin as a supporting inflammatory marker in discriminating SARS-CoV-2 infection: an observational study	51
Immune-related genetic single-nucleotide polymorphisms contribute to prognosis and response to chemotherapy in patients with acute lymphoblastic leukemia	48
Viperin inhibits interferon-γ production to promote Mycobacterium tuberculosis survival by disrupting TBK1-IKKε-IRF3-axis and JAK-STAT signaling	45
Paradoxical expression of NRP1 in decidual stromal and immune cells reveals a novel inflammation balancing mechanism during early pregnancy	44
Kinin B1 receptor and TLR4 interaction in inflammatory response	43
The role of dietary fibre in lung inflammation: microbiota, metabolites, and immune crosstalk	42
HMGB1: key mediator in digestive system diseases	42
Unveiling the role of ABI3 and hub senescence-related genes in macrophage senescence for atherosclerotic plaque progression	41
Serum from COVID-19 patients promotes endothelial cell dysfunction through protease-activated receptor 2	41
Immunity-related GTPase IRGM at the intersection of autophagy, inflammation, and tumorigenesis	40
CD20+ T cells: an emerging T cell subset in human pathology	38
Single-cell hdWGCNA reveals a novel diagnostic model and signature genes of macrophages associated with chronic obstructive pulmonary disease	38
From bench to bedside: targeting lymphocyte activation gene 3 as a therapeutic strategy for autoimmune diseases	37

Association of risk of incident acne and treatment with systemic Janus kinase inhibitors in atopic dermatitis: a systematic review and meta-analysis	37
The NADase CD38 is a central regulator in gouty inflammation and a novel druggable therapeutic target	35
Inhibition of glycolytic reprogramming suppresses innate immune-mediated inflammation in experimental amyotrophic lateral sclerosis	34
A pain from the nose to the head: neurological commitment during long COVID	33
IL-1 receptor antagonist: etiological and drug delivery systems overview	33
A suitable model to investigate acute neurological consequences of coronavirus infection	33
Annexin A1 is crucial during Toxoplasma gondii infection promoting the modulation of inflammation and intestinal and central nervous system barrier functions	31
Infliximab modifies CD74-mediated lymphatic abnormalities and adipose tissue alterations in creeping fat of Crohn’s disease	31
LncGBP9 knockdown alleviates myocardial inflammation and apoptosis in mice with acute viral myocarditis via suppressing NF-κB signaling pathway	31
Successful treatment of refractory erythrodermic pemphigus foliaceus with low-dose rituximab and intravenous immunoglobulin	30
Internalization of benzylisoquinoline alkaloids by resting and activated bone marrow-derived mast cells utilizes energy-dependent mechanisms	30
Acute lung injury: a view from the perspective of necroptosis	29
Mitochondrial proteomics reveals the impact of Estrogen in enhancing energy metabolism of patient-derived fibroblast-like synoviocytes in rheumatoid arthritis	28
Treg plasticity and human diseases	27
The HMGB1-RAGE axis induces apoptosis in acute respiratory distress syndrome through PERK/eIF2α/ATF4-mediated endoplasmic reticulum stress	27
Functional characterization of novel anti-DEFA5 monoclonal antibody clones 1A8 and 4F5 in inflammatory bowel disease colitis tissues	26
Extracellular histones induce inflammation and senescence of vascular smooth muscle cells by activating the AMPK/FOXO4 signaling pathway	26
Caffeine alleviates acute liver injury by inducing the expression of NEDD4L and deceasing GRP78 level via ubiquitination	26
Antigen-specific reduced IgG inhibits cellular response in rat basophilic leukemia cells activated with multivalent antigen	26
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia–reperfusion injury	26
Immune response associated with ischemia and reperfusion injury during organ transplantation	25
Disulfidptosis-related genes RPN1 inhibits the progression of hepatocellular carcinoma by regulating cell cycle, may be a new therapeutic targets	24
Dog allergen-induced asthma in mice: a relevant model of T2low severe asthma with airway remodelling	23
SS-31 inhibits mtDNA–cGAS–STING signaling to improve POCD by activating mitophagy in aged mice	23
Identification of RRM2 as a key ferroptosis-related gene in sepsis	23
SIRT6 inhibits endoplasmic reticulum stress-mediated ferroptosis by activating Nrf2/HO-1 signaling to alleviate osteoarthritis	23
Identification of ferroptosis-related genes and potential drugs in osteoarthritis	22
Piezo1 exacerbates psoriasis by promoting macrophage M1 polarization and inhibits autophagy via activating PI3K/AKT signaling pathway	22
Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders	22
Quercetin and Kaempferol inhibit HMC-1 activation via SOCE/NFATc2 signaling and suppress hippocampal mast cell activation in lipopolysaccharide-induced depressive mice	21
Alleviated NCOA4-mediated ferritinophagy protected RA FLSs from ferroptosis in lipopolysaccharide-induced inflammation under hypoxia	21
Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis	21
Prolonged effects of DPP-4 inhibitors on steato-hepatitic changes in Sprague–Dawley rats fed a high-cholesterol diet	21
Inflammation, coagulation, and cellular injury in heat-induced shock	21
Genetic correlations, shared risk genes and immunity landscapes between COVID-19 and venous thromboembolism: evidence from GWAS and bulk transcriptome data	20
Identification of inflammatory protein biomarkers for predicting the different subtype of adult with tuberculosis: an Olink proteomic study	20
Treatment with lipoxin A4 improves influenza A infection outcome, induces macrophage reprogramming, anti-inflammatory and pro-resolutive responses	20
Characterization of immune landscape and development of a novel N7-methylguanine-related gene signature to aid therapy in recurrent aphthous stomatitis	20
Granulocyte macrophage colony stimulating factor exerts dominant effects over macrophage colony stimulating factor during macrophage differentiation in vitro to induce an inflammatory phenotype	19
USP10 regulates macrophage inflammation responses via stabilizing NEMO in LPS-induced sepsis	19
Mechanisms of COVID-19-induced kidney injury and current pharmacotherapies	19
Prospective study of an adalimumab combined with partial enteral nutrition in the induction period of Crohn’s disease	19
Exocytic machineries differentially control mediator release from allergen-triggered RBL-2H3 cells	18
Human antimicrobial/host defense peptide LL-37 may prevent the spread of a local infection through multiple mechanisms: an update	18
Inflammatory biomarkers on an LPS-induced RAW 264.7 cell model: a systematic review and meta-analysis	18
Retraction Note: Knockdown of long non‑coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA‑15a and repressing ROCK1 expression	18
Modulation of Plet1 expression by N-Acetylglucosamine through the IL-17 A-MAPK pathway in an imiquimod-induced psoriasis mouse model	17
IL-35 modulates Tfh2 and Tfr cell balance to alleviate allergic rhinitis	17
The combination of metabolic syndrome and inflammation increased the risk of colorectal cancer	17
Inflammatory cell death PANoptosis is induced by the anti-cancer curaxin CBL0137 via eliciting the assembly of ZBP1-associated PANoptosome	17

Chronic ethanol exposure decreases H3K27me3 in the Il6 promoter region of macrophages and generates persistent dysfunction on neutrophils during fungal infection	17
Roquin-1 interaction with Regnase-1 inhibits the progression of rheumatoid arthritis via suppressing FGF2 expression and NF-κB pathway	17
Commentaries: Lecanemab: pioneering the way as the first approved drug for Alzheimer’s disease treatment	17
The star target in SLE: IL-17	16
The molecular mechanisms of remodeling in asthma, COPD and IPF with a special emphasis on the complex role of Wnt5A	16
Mechanism of action of M-XQLD treatment for asthma: role of STARD13 in Th17 suppression	16
Interlukin-23 inhibitors as an induction and maintenance therapy for moderate to severe ulcerative colitis: a systematic review and meta‑analysis of randomized controlled trials	16
Monogenic autoinflammatory disease-associated cardiac damage	16
STAT1-mediated induction of Ly6c-expressing macrophages are involved in the pathogenesis of an acute colitis model	16
The combination of machine learning and untargeted metabolomics identifies the lipid metabolism -related gene CH25H as a potential biomarker in asthma	15
Minocycline alleviates microglia ferroptosis by inhibiting HO-1 during cerebral ischemia–reperfusion injury	15
Enhancing effect of sodium butyrate on phosphatidylserine–liposome-induced macrophage polarization	15
Molecular biology of the novel anticancer medications: a focus on kinases inhibitors, biologics and CAR T-cell therapy	15
IL-35 promotes IL-35+IL-10+ Bregs and Conventional LAG3+ Tregs in the lung tissue of OVA-Induced Asthmatic Mice	15
Influence of homocysteine on regulating immunothrombosis: mechanisms and therapeutic potential in management of infections	15
Salidroside alleviates cadmium-induced toxicity in mice by restoring the notch/HES-1 and RIP1-driven inflammatory signaling axis	15
COVID-19 pandemic: the delta variant, T-cell responses, and the efficacy of developing vaccines	15
CD8 + T cell-based molecular subtypes with heterogeneous immune landscapes and clinical significance in acute myeloid leukemia	15
SRY-related high-mobility group box 9 (SOX9) alleviates cigarette smoke extract (CSE)-induced inflammatory injury in human bronchial epithelial cells by suppressing stromal interaction molecule 1 (STI	15
The role of regulatory T cells in vitiligo and therapeutic advances: a mini-review	15
Challenges and opportunities in inflammatory bowel disease: from current therapeutic strategies to organoid-based models	15
Single-cell transcriptome analysis of the mouse lungs during the injury and recovery periods after lipopolysaccharide administration	15
Mechanosensitive ion channels and inflammation: key links in cellular signal transduction	15
Characterizing the kinetics of presepsin and associated inflammatory biomarkers in human endotoxemia	15
Selective inhibition of PKR by C16 accelerates diabetic wound healing by inhibiting NALP3 expression in mice	15
Prostacyclin synthase deficiency exacerbates systemic inflammatory responses in lipopolysaccharide-induced septic shock in mice	14
MitoQ alleviates mitochondria damage in sepsis-acute lung injury in a citrate synthase dependent manner	14
Miconazole attenuates LPS-induced lung inflammation by modulating alveolar macrophage polarization via promoting lipid metabolic reprogramming	14
5-oxoETE promote thrombosis in antiphospholipid syndrome by triggering NETs formation through PLC/PKC/ERK pathway	14
Salmonella spvC gene suppresses macrophage/neutrophil antibacterial defense mediated by gasdermin D	14
Retraction Note: Emerging protective roles of shengmai injection in septic cardiomyopathy in mice by inducing myocardial mitochondrial autophagy via caspase-3/Beclin-1 axis	14
Correction to: Fructose malabsorption in ChREBP-deficient mice disrupts the small intestine immune microenvironment and leads to diarrhea-dominant bowel habit changes	14
The clinical trajectory of peripheral blood immune cell subsets, T-cell activation, and cytokines in septic patients	14
Interleukin 15 and autoimmune disorders: pathophysiology, therapeutic potential, and clinical implications	14
Environmental and inflammatory factors influencing concurrent gut and lung inflammation	14
Long-pulsed 1064-nm neodymium: yttrium-aluminum-garnet laser alleviates rosacea by improving lymphatic vessel dysfunction	13
Association of systemic immune-inflammation index and systemic inflammation response index with chronic kidney disease: observational study of 40,937 adults	13
GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis	13
Targeting ACE2 as a potential prophylactic strategy against COVID-19-induced exacerbation of chronic kidney disease	13
Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation	13
Altered vacuole membrane protein 1 (VMP1) expression is associated with increased NLRP3 inflammasome activation and mitochondrial dysfunction	13
Plant extracts and omega-3 supplementation modulate hippocampal oxylipin profile in response to LPS-induced neuroinflammation	13
Multimodal data-driven prognostic model for predicting new-onset ST-elevation myocardial infarction following emergency percutaneous coronary intervention	13
Exploring macrophage and nerve interaction in endometriosis-associated pain: the inductive role of IL-33	13
Bone marrow mesenchymal stem cells-derived exosomes containing miR-539-5p inhibit pyroptosis through NLRP3/caspase-1 signalling to alleviate inflammatory bowel disease	13
The causal effect of natural killer cells on COVID-19 infection, hospitalization and severity	13
Aryl hydrocarbon receptor (AhR) alleviates the LPS-induced inflammatory responses in IPEC-J2 cells by activating PINK1/Parkin-mediated mitophagy	12
STING deficiency protects against wasp venom-induced acute kidney injury	12
Recognition of Mycobacterium tuberculosis by macrophage Toll-like receptor and its role in autophagy	12
Retraction Note to: Suppressors of cytokine signalling (SOCS)‑1 inhibits neuroinflammation by regulating ROS and TLR4 in BV2 cells	12
Comprehensive analysis of single cell and bulk RNA sequencing reveals the heterogeneity of melanoma tumor microenvironment and predicts the response of immunotherapy	12
Decoy oligonucleotides targeting NF-κB: a promising therapeutic approach for inflammatory diseases	12
Histamine regulates the activity and the expression of the Na+/H+ exchanger (NHE)3 in human epithelial HK-2 cells	12
Rhein-attenuates LPS-induced acute lung injury via targeting NFATc1/Trem2 axis	12
Transcriptomic analysis reveals molecular characterization and immune landscape of PANoptosis-related genes in atherosclerosis	12
Histamine research advancements in the second year of the COVID-19 pandemic: report of the European Histamine Research Society (EHRS)	12
Diamine oxidase knockout mice are not hypersensitive to orally or subcutaneously administered histamine	12
Causal role of myeloid cells in Parkinson’s disease: Mendelian randomization study	12
Bioinformatics analysis for identifying micro-RNAs, long noncoding RNAs, transcription factors, and immune genes regulatory networks in diabetic cardiomyopathy using an integrated bioinformatics analy	12
Mediation of macrophage M1 polarization dynamics change by ubiquitin-autophagy-pathway regulated NLRP3 inflammasomes in PD-1 inhibitor-related myocardial inflammatory injury	12
Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro	12
The potential roles of Th17 cells in the pathogenesis of oral lichen planus	12
Immunopathogenesis of urticaria: a clinical perspective on histamine and cytokine involvement	12
Screening inflammatory protein biomarkers on premature infants with necrotizing enterocolitis	12
Vitamin D3 suppresses NLRP3 inflammasome pathway and enhances steroid sensitivity in a neutrophilic steroid hyporesponsive asthma mouse model	12
Biological attributes of zinc-dependent endopeptidases in endothelial dysfunction associated with sepsis: a narrative review	11
Simultaneously blocking ANGPTL3 and IL-1β for the treatment of atherosclerosis through lipid-lowering and anti-inflammation	11
Pentoxifylline in COVID-19 and considerations for its research in long COVID	11
Agomir miRNA-150-5p alleviates pristane-induced lupus by suppressing myeloid dendritic cells activation and inflammation via TREM-1 axis	11
Lipoxin alleviates oxidative stress: a state-of-the-art review	11
The IL-6 autocrine loop promoting IFN-γ-induced fibroblast senescence is involved in psychological stress-mediated exacerbation of vitiligo	11
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19	11
Long-COVID fatigue is not predicted by pre-pandemic plasma IL-6 levels in mild COVID-19	11
Bridging worlds: a narrative review of IL-17 at the crossroads of inflammation and thrombosis	11
Calycosin inhibited MIF-mediated inflammatory chemotaxis of macrophages to ameliorate ischemia reperfusion-induced acute kidney injury	11
ADAM10-a “multitasker” in sepsis: focus on its posttranslational target	11