American Journal of Physiology-Lung Cellular and Molecular Physiology

Article	Citations
Healing after COVID-19: are survivors at risk for pulmonary fibrosis?	159
Estrogen regulates the expression of SARS-CoV-2 receptor ACE2 in differentiated airway epithelial cells	157
Heparin as a therapy for COVID-19: current evidence and future possibilities	146
Novel insights on the pulmonary vascular consequences of COVID-19	116
First contact: the role of respiratory cilia in host-pathogen interactions in the airways	103
The SARS-CoV-2 spike protein subunit S1 induces COVID-19-like acute lung injury in Κ18-hACE2 transgenic mice and barrier dysfunction in human endothelial cells	82
Thoughts on the alveolar phase of COVID-19	77
The Idiopathic Pulmonary Fibrosis Cell Atlas	71
Understanding the age divide in COVID-19: why are children overwhelmingly spared?	70
COPD 2020: changes and challenges	69
Disequilibrium between the classic renin-angiotensin system and its opposing arm in SARS-CoV-2-related lung injury	61
SARS-CoV-2 may regulate cellular responses through depletion of specific host miRNAs	59
Lung immune tone via gut-lung axis: gut-derived LPS and short-chain fatty acids’ immunometabolic regulation of lung IL-1β, FFAR2, and FFAR3 expression	58
Covid-19 infection and mortality: a physiologist’s perspective enlightening clinical features and plausible interventional strategies	54
Deregulated miRNA expression is associated with endothelial dysfunction in post-mortem lung biopsies of COVID-19 patients	54
Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach	49
Structural and functional variations in human bronchial epithelial cells cultured in air-liquid interface using different growth media	48
Sex steroids skew ACE2 expression in human airway: a contributing factor to sex differences in COVID-19?	46
Inflammasome activation in acute lung injury	44
Carrageenan-containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures	42
Is there an association between the level of ambient air pollution and COVID-19?	41
The hallmarks of severe pulmonary arterial hypertension: the cancer hypothesis—ten years later	41
SARS-CoV-2 (COVID-19) and cystic fibrosis	41
Neutrophil extracellular traps activate IL-8 and IL-1 expression in human bronchial epithelia	40
The rise of electronic nicotine delivery systems and the emergence of electronic-cigarette-driven disease	40

SARS-CoV-2 may hijack GPCR signaling pathways to dysregulate lung ion and fluid transport	39
E-cigarette constituents propylene glycol and vegetable glycerin decrease glucose uptake and its metabolism in airway epithelial cells in vitro	39
Link between increased cellular senescence and extracellular matrix changes in COPD	38
Human coronaviruses 229E and OC43 replicate and induce distinct antiviral responses in differentiated primary human bronchial epithelial cells	37
Hyperoxia and modulation of pulmonary vascular and immune responses in COVID-19	37
P-selectin blockade in COVID-19-related ARDS	36
The oxygen dissociation curve of blood in COVID-19	36
COPD 2020: new directions needed	34
The potential role of the carotid body in COVID-19	33
World Sepsis Day: a global agenda to target a leading cause of morbidity and mortality	33
Altered lung metabolism and mitochondrial DAMPs in lung injury due to acute kidney injury	32
Lysyl oxidase directly contributes to extracellular matrix production and fibrosis in systemic sclerosis	31
Erythrocytes identify complement activation in patients with COVID-19	29
Intratracheal administration of mesenchymal stem cell-derived extracellular vesicles reduces lung injuries in a chronic rat model of bronchopulmonary dysplasia	29
Identification of lung innervating sensory neurons and their target specificity	28
A pilot study to assess the circulating renin-angiotensin system in COVID-19 acute respiratory failure	28
The role of MIF in chronic lung diseases: looking beyond inflammation	28
TBK1 regulates YAP/TAZ and fibrogenic fibroblast activation	27
Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures	27
Resistin family proteins in pulmonary diseases	27
Strong correlation between air-liquid interface cultures and in vivo transcriptomics of nasal brush biopsy	26
Kinins and chymase: the forgotten components of the renin-angiotensin system and their implications in COVID-19 disease	26
Recent advances in understanding the ecology of the lung microbiota and deciphering the gut-lung axis	26
Pathogenesis, clinical features of asthma COPD overlap, and therapeutic modalities	26
Alveolar heparan sulfate shedding impedes recovery from bleomycin-induced lung injury	25
Mitochondrial 8-oxoguanine DNA glycosylase mitigates alveolar epithelial cell PINK1 deficiency, mitochondrial DNA damage, apoptosis, and lung fibrosis	25
Treatment of COVID-19-exacerbated asthma: should systemic corticosteroids be used?	25
IL-4/IL-13 upregulates Sonic hedgehog expression to induce allergic airway epithelial remodeling	24
Lung-resident mesenchymal stromal cells are tissue-specific regulators of lung homeostasis	24
Consideration of Pannexin 1 channels in COVID-19 pathology and treatment	24
Demystifying pulmonary fibrosis	24
Lung health, tobacco, and related products: gaps, challenges, new threats, and suggested research	24
Titanium dioxide nanoparticles exaggerate respiratory syncytial virus-induced airway epithelial barrier dysfunction	24
Vitamin D supplementation as a rational pharmacological approach in the COVID-19 pandemic	24
Molecular mechanisms of Na,K-ATPase dysregulation driving alveolar epithelial barrier failure in severe COVID-19	23
Platelet activation contributes to hypoxia-induced inflammation	23
TRPC6, a therapeutic target for pulmonary hypertension	23
Is targeting Akt a viable option to treat advanced-stage COVID-19 patients?	23
The FOXA1 transcriptional network coordinates key functions of primary human airway epithelial cells	23
Differential responses to e-cig generated aerosols from humectants and different forms of nicotine in epithelial cells from nonsmokers and smokers	23
TNFα induces mitochondrial fragmentation and biogenesis in human airway smooth muscle	23
Intra-alveolar neutrophil-derived microvesicles are associated with disease severity in COPD	22
Comprehensive review of lipocalin 2-mediated effects in lung inflammation	22
Angiotensin-converting enzyme 2 and COVID-19: patients, comorbidities, and therapies	22
Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation	21
The short-chain free fatty acid receptor FFAR3 is expressed and potentiates contraction in human airway smooth muscle	21
Distinct types of plexiform lesions identified by synchrotron-based phase-contrast micro-CT	21
High-dimensional single-cell analysis reveals the immune characteristics of COVID-19	21
Implications of preexisting asthma on COVID-19 pathogenesis	21
E-cigarettes and health risks: more to the flavor than just the name	21

A neutrophil subset defined by intracellular olfactomedin 4 is associated with mortality in sepsis	21
COVID-19: is the ACE2 just a foe?	21
Cigarette smoke induction of S100A9 contributes to chronic obstructive pulmonary disease	21
Aging impairs alveolar epithelial type II cell function in acute lung injury	21
Right ventricular pressure-volume loop shape and systolic pressure change in pulmonary hypertension	20
Vitamin D deficiency downregulates TASK-1 channels and induces pulmonary vascular dysfunction	20
Dysregulation of endocytic machinery and ACE2 in small airways of smokers and COPD patients can augment their susceptibility to SARS-CoV-2 (COVID-19) infections	20
The evolving role of the lung microbiome in pulmonary fibrosis	20
Glucose-6-phosphate dehydrogenase deficiency contributes to metabolic abnormality and pulmonary hypertension	20
Glucocorticoid regulates mesenchymal cell differentiation required for perinatal lung morphogenesis and function	20
Differential effects of the cystic fibrosis lung inflammatory environment on mesenchymal stromal cells	20
Disease modeling following organoid-based expansion of airway epithelial cells	19
Neonatal therapy with PF543, a sphingosine kinase 1 inhibitor, ameliorates hyperoxia-induced airway remodeling in a murine model of bronchopulmonary dysplasia	19
Compartment-specific transcriptomics of ozone-exposed murine lungs reveals sex- and cell type-associated perturbations relevant to mucoinflammatory lung diseases	19
Microvesicles in bronchoalveolar lavage as a potential biomarker of COPD	19
The effect of estrogen in coronavirus disease 2019	18
MitoTEMPOL, a mitochondrial targeted antioxidant, prevents sepsis-induced diaphragm dysfunction	18
Angiotensin-converting enzyme 2 expression in COPD and IPF fibroblasts: the forgotten cell in COVID-19	18
A cGAS-dependent response links DNA damage and senescence in alveolar epithelial cells: a potential drug target in IPF	18
Phenylalanine induces pulmonary hypertension through calcium-sensing receptor activation	18
A toolbox for studying respiratory viral infections using air-liquid interface cultures of human airway epithelial cells	18
Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection	17
The importance of reporting house dust mite endotoxin abundance: impact on the lung transcriptome	17
Bacterial extracellular vesicles isolated from organic dust induce neutrophilic inflammation in the lung	17
MUC1 contributes to goblet cell metaplasia and MUC5AC expression in response to cigarette smoke in vivo	17
CFTR function and clinical response to modulators parallel nasal epithelial organoid swelling	17
Lung proteomic biomarkers associated with chronic obstructive pulmonary disease	16
Immunoglobulin deficiency as an indicator of disease severity in patients with COVID-19	16
Extracellular vesicle miRNA-21 is a potential biomarker for predicting chronic lung disease in premature infants	16
Therapeutic efficacy of IL-17A neutralization with corticosteroid treatment in a model of antigen-driven mixed-granulocytic asthma	16
Mechanosensitive channel Piezo1 is required for pulmonary artery smooth muscle cell proliferation	16
The common ABCA3E292V variant disrupts AT2 cell quality control and increases susceptibility to lung injury and aberrant remodeling	16
Real-time measurement of cellular bioenergetics in fully differentiated human nasal epithelial cells grown at air-liquid-interface	16
Isolation of high-yield and -quality RNA from human precision-cut lung slices for RNA-sequencing and computational integration with larger patient cohorts	16
Chemokines, soluble PD-L1, and immune cell hyporesponsiveness are distinct features of SARS-CoV-2 critical illness	16
In well-differentiated primary human bronchial epithelial cells, TGF-β1 and TGF-β2 induce expression of furin	16
Circulating miRNA 887 is differentially expressed in ARDS and modulates endothelial function	15
Call for Papers: The Pathophysiology of COVID-19 and SARS-CoV-2 Infection	15
Paramyxovirus replication induces the hexosamine biosynthetic pathway and mesenchymal transition via the IRE1α-XBP1s arm of the unfolded protein response	15
microRNA-223 promotes autophagy to aggravate lung ischemia-reperfusion injury by inhibiting the expression of transcription factor HIF2α	15
Insulin acutely increases agonist-induced airway smooth muscle contraction in humans and rats	15
UCHL1, a deubiquitinating enzyme, regulates lung endothelial cell permeability in vitro and in vivo	15
Toxic effects of cell-free hemoglobin on the microvascular endothelium: implications for pulmonary and nonpulmonary organ dysfunction	15
Potential role for nitazoxanide in treating SARS-CoV-2 infection	15
Absolute quantification of plasma mitochondrial DNA by droplet digital PCR marks COVID-19 severity over time during intensive care unit admissions	14
From pulmonary fibrosis to progressive pulmonary fibrosis: a lethal pathobiological jump	14
Understanding potential mechanisms of harm: the drivers of electronic cigarette-induced changes in alveolar macrophages, neutrophils, and lung epithelial cells	14
World Prematurity Day: improving survival and quality of life for millions of babies born preterm around the world	14
Abnormalities in reparative function of lung-derived mesenchymal stromal cells in emphysema	14
Normal murine respiratory tract has its mucus concentrated in clouds based on the Muc5b mucin	14
Recent updates on biomarkers of exposure and systemic toxicity in e-cigarette users and EVALI	14
Abrogation of mesenchyme-specific TGF-β signaling results in lung malformation with prenatal pulmonary cysts in mice	14
Role of the renin-angiotensin system in the development of severe COVID-19 in hypertensive patients	14
Intratracheal budesonide/surfactant attenuates hyperoxia-induced lung injury in preterm rabbits	14
S100A4 is secreted by airway smooth muscle tissues and activates inflammatory signaling pathways via receptors for advanced glycation end products	14
Essential role of IL-23 in the development of acute exacerbation of pulmonary fibrosis	14
NADPH oxidase-mediated endothelial injury in HIV- and opioid-induced pulmonary arterial hypertension	14
Call it by the correct name—pulmonary hypertension not pulmonary arterial hypertension: growing recognition of the global health impact for a well-recognized condition and the role of the Pulmonary Va	14
Antenatal mesenchymal stromal cell extracellular vesicle treatment preserves lung development in a model of bronchopulmonary dysplasia due to chorioamnionitis	13
Depletion of microRNA-451 in response to allergen exposure accentuates asthmatic inflammation by regulating Sirtuin2	13
Combined control of the fibroblast contractile program by YAP and TAZ	13
Ex vivo lung perfusion for donor lung assessment and repair: a review of translational interspecies models	13
Gas exchange calculation may estimate changes in pulmonary blood flow during veno-arterial extracorporeal membrane oxygenation in a porcine model	13
Exoenzyme Y induces extracellular active caspase-7 accumulation independent from apoptosis: modulation of transmissible cytotoxicity	13
An American Physiological Society cross-journal Call for Papers on “Inter-Organ Communication in Homeostasis and Disease”	13
Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells	13
IL10 trains macrophage profibrotic function after lung injury	13
Tert-butylhydroquinone augments Nrf2-dependent resilience against oxidative stress and improves survival of ventilator-induced lung injury in mice	13
Cross-species integration of single-cell RNA-seq resolved alveolar-epithelial transitional states in idiopathic pulmonary fibrosis	13
A simple method to generate human airway epithelial organoids with externally orientated apical membranes	13
Single-cell RNA sequencing reveals unique monocyte-derived interstitial macrophage subsets during lipopolysaccharide-induced acute lung inflammation	12
Normal mesothelial cell lines newly derived from human pleural biopsy explants	12
Protein tyrosine phosphatase-α amplifies transforming growth factor-β-dependent profibrotic signaling in lung fibroblasts	12
Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice	12
A murine model of hereditary pulmonary alveolar proteinosis caused by homozygous Csf2ra gene disruption	12
Interactive and independent effects of early lipopolysaccharide and hyperoxia exposure on developing murine lungs	12
Inhibition of macrophage migration inhibitory factor (MIF) as a therapeutic target in bleomycin-induced pulmonary fibrosis rats	12
Inhaled vitamin A is more effective than intramuscular dosing in mitigating hyperoxia-induced lung injury in a neonatal rat model of bronchopulmonary dysplasia	12
IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis	12
Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma	12

Human microphysiological models of airway and alveolar epithelia	12
Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia	12
Oxidized phosphatidylcholines induce multiple functional defects in airway epithelial cells	12
Why new biology must be uncovered to advance therapeutic strategies for chronic obstructive pulmonary disease	12
Exposure to the heated tobacco product IQOS generates apoptosis-mediated pulmonary emphysema in murine lungs	12
The dual phosphodiesterase 3/4 inhibitor RPL554 stimulates rare class III and IV CFTR mutants	12
Standardization of methods for sampling the distal airspace in mechanically ventilated patients using heat moisture exchange filter fluid	12
Profibrotic epithelial TGF-β1 signaling involves NOX4-mitochondria cross talk and redox-mediated activation of the tyrosine kinase FYN	12
Aerosolized vitamin E acetate causes oxidative injury in mice and in alveolar macrophages	12
Lung disease manifestations in Down syndrome	12
Surfactant-secreted phospholipase A2interplay and respiratory outcome in preterm neonates	11
Androgen receptor activation alleviates airway hyperresponsiveness, inflammation, and remodeling in a murine model of asthma	11
Woodsmoke particle exposure prior to SARS-CoV-2 infection alters antiviral response gene expression in human nasal epithelial cells in a sex-dependent manner	11
A systematic analysis of protein-altering exonic variants in chronic obstructive pulmonary disease	11
Advanced single-cell technologies to guide the development of bioengineered lungs	11
CD14-positive extracellular vesicles in bronchoalveolar lavage fluid as a new biomarker of acute respiratory distress syndrome	11
Lung-kidney interactions and their role in chronic kidney disease-associated pulmonary diseases	11
The role of extracellular vesicles in traumatic brain injury-induced acute lung injury	11
Pericytes as novel targets for HIV/SIV infection in the lung	11
Caspase-11 contributes to pulmonary host defense against Klebsiella pneumoniae and local activation of coagulation	11
World Pneumonia Day during a global pneumonia pandemic: 12 November 2020	11
TLR4 is required for macrophage efferocytosis during resolution of ventilator-induced lung injury	11
A method for translational rat ex vivo lung perfusion experimentation	11
OGR1-dependent regulation of the allergen-induced asthma phenotype	11
RSV attenuates epithelial cell restitution by inhibiting actin cytoskeleton-dependent cell migration	11
Expression of serum response factor in the lung mesenchyme is essential for development of pulmonary fibrosis	11
Cigarette smoke preparations, not electronic nicotine delivery system preparations, induce features of lung disease in a 3D lung repeat-dose model	11
Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS	11
PCD Detect: enhancing ciliary features through image averaging and classification	10
The aryl hydrocarbon receptor reduces LC3II expression and controls endoplasmic reticulum stress	10
Intermittent CPAP limits hyperoxia-induced lung damage in a rabbit model of bronchopulmonary dysplasia	10
MRSA-induced endothelial permeability and acute lung injury are attenuated by FTY720 S-phosphonate	10
Resveratrol restores intracellular transport in cystic fibrosis epithelial cells	10
Age-associated differences in the human lung extracellular matrix	10
LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE	10
Passive siRNA transfection method for gene knockdown in air-liquid interface airway epithelial cell cultures	10
Circulating extracellular histones exacerbate acute lung injury by augmenting pulmonary endothelial dysfunction via TLR4-dependent mechanism	10
Blood fibrocytes are associated with severity and prognosis in COVID-19 pneumonia	10
Obesity and diabetes: similar respiratory mechanical but different gas exchange defects	10
Rho/ROCK-MYOCD in regulating airway smooth muscle growth and remodeling	10
RSV infection potentiates TRPV1-mediated calcium transport in bronchial epithelium of asthmatic children	10
Hyaluronan/CD44 axis regulates S100A4-mediated mesenchymal progenitor cell fibrogenicity in idiopathic pulmonary fibrosis	10
Separating the contributions of SLC26A9 and CFTR to anion secretion in primary human bronchial epithelia	10
CF monocyte-derived macrophages have an attenuated response to extracellular vesicles secreted by airway epithelial cells	10
VEGF/Src signaling mediated pleural barrier damage and increased permeability contributes to subpleural pulmonary fibrosis	10
Attenuation of relaxing response induced by pituitary adenylate cyclase-activating polypeptide in bronchial smooth muscle of experimental asthma	10
Protein biomarkers and risk scores in pulmonary arterial hypertension associated with ventricular septal defect: integration of multi-omics and validation	10
ARDS Metabolic Fingerprints: Characterization, Benchmarking and Potential Mechanistic Interpretation	10