OOIR: Observatory of International Research

Papers

(The median citation count of Critical Reviews in Clinical Laboratory Sciences is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Deep learning algorithms and Raman spectroscopy in the clinical laboratory setting	164
Advances and challenges in the measurement of 1,25-dihydroxyvitamin D: a comprehensive review	73
Data analytics for error detection in clinical laboratories	64
The anion gap as a predictive tool for morbidity and mortality	53
Machine learning-based error detection in the clinical laboratory: a critical review	47
Breathing new life into clinical testing and diagnostics: perspectives on volatile biomarkers from breath	42
Lipoprotein(a): a genetically determined risk factor for Cardiovascular disease	39
Human telomere length detected by quantitative fluorescent in situ hybridization: overlooked importance and application	37
Copeptin as a surrogate marker for arginine vasopressin: analytical insights, current utility, and emerging applications	35
Transthyretin mutagenesis: impact on amyloidogenesis and disease	35
Clinical utility of human epididymis protein 4	33
Evaluating thyroid function in pregnant women	30
The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology	30
Comparison of liquid biopsy-based technologies for cancer screening	29
Guidance for securing approvals for new biomarkers: from discovery to clinical implementation	26
KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis as biomarker	26
Beyond newborn screening: the role of reverse cascade testing in familial disease detection	26
Cardiovascular disease lipids and lipoproteins biomarker standardization	23
Development of next-generation reference interval models to establish reference intervals based on medical data: current status, algorithms and future consideration	23
One health and laboratory medicine: challenges and perspectives for antimicrobial resistance, emerging infections, and food/water security	20
Challenges of insulin-like growth factor-1 testing	19
It’s in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19	19
Association of inflammatory biomarkers with morbidity and mortality risk in patients with peripheral artery disease: a systematic review and meta-analysis	19
Omics-based computational approaches for biomarker identification, prediction, and treatment of Long COVID	18
Analytical and clinical considerations of synovial fluid calprotectin in diagnosing periprosthetic joint infections	18

Emerging applications of machine learning in genomic medicine and healthcare	18
Using a systematic approach to strategic innovation in laboratory medicine to bring about change	17
Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future	16
Pleural fluid biomarkers for the diagnosis and management of malignant pleural effusions: a clinical review	15
The intersection of the laboratory and transgender care	15
Therapeutic biomarkers in metastatic castration-resistant prostate cancer: does the state matter?	15
The urocortin peptides: biological relevance and laboratory aspects of UCN3 and its receptor	14
Guidelines for diagnosing and differentiating infection with antifungal-resistant Trichophyton indotineae from other dermatophytoses	14
Methodological and conceptual challenges to the flow cytometric classification of leukemic lymphoproliferative disorders	14
General features, pathogenesis, and laboratory diagnostics of autoimmune encephalitis	14
Insight into metabolic dysregulation of polycystic ovary syndrome utilizing metabolomic signatures: a narrative review	13
Circulating tumor DNA (ctDNA): can it be used as a pan-cancer early detection test?	13
Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)	12
Effects of age, sex, serostatus, and underlying comorbidities on humoral response post-SARS-CoV-2 Pfizer-BioNTech mRNA vaccination: a systematic review	12
DNA/RNA-based electrochemical nanobiosensors for early detection of cancers	12
Free thyroxine measurement in clinical practice: how to optimize indications, analytical procedures, and interpretation criteria while waiting for global standardization	11
Point of care blood glucose devices in the hospital setting	11
Advances in internal quality control	10
The multidimensional value of natriuretic peptides in heart failure, integrating laboratory and clinical aspects	10
From fructose to the future: liver disease biomarkers and their prognostic value in acute liver failure	10
Erroneous potassium results: preanalytical causes, detection, and corrective actions	9
Establishing, evaluating and monitoring analytical quality in the traceability era	8
Genotype-phenotype correlation in the spectrum of frontotemporal dementia-parkinsonian syndromes and advanced diagnostic approaches	8
Systematic review and meta-analysis of C-reactive protein as a biomarker in breast cancer	8
Genetic variants of accessory proteins and G proteins in human genetic disease	7
Research progress of KL-6 in respiratory system diseases	7
Design, optimization, and application of multiplex rRT-PCR in the detection of respiratory viruses	7
Omics-based novel strategies in the diagnosis of endometriosis	7
Estimating glomerular filtration rate with new equations: can one size ever fit all?	7
Correction	7
Parallelism in neurodegenerative biomarker tests: hidden errors and the risk of misconduct	7
Beyond the amyloid hypothesis: how current research implicates autoimmunity in Alzheimer’s disease pathogenesis	6
Large scale implementation of DP for clinical diagnoses: experience, challenges, and lessons learned	6
The current state in liquid chromatography-mass spectrometry methods for quantifying kynurenine pathway metabolites in biological samples: a systematic review	6
Pre-analytical conditions and implementation of quality control steps in liquid biopsy analysis	6
From population-based to personalized laboratory medicine: continuous monitoring of individual laboratory data with wearable biosensors	6
Loop-mediated isothermal amplification (LAMP)-based microbial detection: a review of FDA-authorized tests and future perspectives	6
Advances in minimal residual disease monitoring in multiple myeloma	6
Analytical performance specifications and quality assurance of point-of-care testing in primary healthcare	6
Pathologist workload, burnout, and wellness: connecting the dots	6
Implementation of pharmacogenomics testing for precision medicine	6
Screening and diagnosis of inherited platelet disorders	6
Machine learning models for acute kidney injury prediction and management: a scoping review of externally validated studies	5
Unveiling Parkinson’s disease through biomarker research: current insights and future prospects	5
Preterm labor tests: current status and future directions	5
The role of immunophenotyping in common variable immunodeficiency: a narrative review	5
Implication of calcium supplementations in health and diseases with special focus on colorectal cancer	5
Current status in cellular-based therapies for prevention and treatment of COVID-19	4
G protein-coupled receptor (GPCR) gene variants and human genetic disease	4
Mapping of audiometric analysis with microbiological findings in patients with chronic suppurative otitis media (CSOM): a neglected clinical manifestation	4

Reference intervals: past, present, and future	4
The influence of antiphospholipid antibodies on prothrombin time and international normalized ratio: a scoping review	4
The European Organisation of External Quality Assurance Providers in Laboratory Medicine (EQALM) Statement: guidelines for publishing about interlaboratory comparison studies (PubILC)	4
Laboratory test utilization and effect on clinical outcomes in a pediatric setting	4
Technical quality assurance and quality control for medical laboratories: a review and proposal of a new concept to obtain integrated and validated QA/QC plans	4
Modern techniques used in the diagnosis of autoimmune rheumatic diseases	4
Lipid-binding antiphospholipid antibodies: significance for pathophysiology and diagnosis of the antiphospholipid syndrome	4
The significance of antigen-antibody-binding avidity in clinical diagnosis	4