OOIR: Observatory of International Research

Papers

(The median citation count of Critical Reviews in Clinical Laboratory Sciences is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Advances and challenges in the measurement of 1,25-dihydroxyvitamin D: a comprehensive review	133
Machine learning-based error detection in the clinical laboratory: a critical review	84
Lipoprotein(a): a genetically determined risk factor for Cardiovascular disease	69
The anion gap as a predictive tool for morbidity and mortality	53
Breathing new life into clinical testing and diagnostics: perspectives on volatile biomarkers from breath	41
Human telomere length detected by quantitative fluorescent in situ hybridization: overlooked importance and application	40
Transthyretin mutagenesis: impact on amyloidogenesis and disease	37
Copeptin as a surrogate marker for arginine vasopressin: analytical insights, current utility, and emerging applications	36
Clinical utility of human epididymis protein 4	31
The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology	30
Evaluating thyroid function in pregnant women	29
Guidance for securing approvals for new biomarkers: from discovery to clinical implementation	28
Cardiovascular disease lipids and lipoproteins biomarker standardization	28
KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis as biomarker	26
Development of next-generation reference interval models to establish reference intervals based on medical data: current status, algorithms and future consideration	25
Quantifying RNA modifications by mass spectrometry: a novel source of biomarkers in oncology	23
Challenges of insulin-like growth factor-1 testing	23
Association of inflammatory biomarkers with morbidity and mortality risk in patients with peripheral artery disease: a systematic review and meta-analysis	22
It’s in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19	22
The molecular structure and biological functions of RNA methylation, with special emphasis on the roles of RNA methylation in autoimmune diseases	21
Physiological and metabolic adaptations in pregnancy: importance of trimester-specific reference intervals to investigate maternal health and complications	21
Using a systematic approach to strategic innovation in laboratory medicine to bring about change	20
Analytical and clinical considerations of synovial fluid calprotectin in diagnosing periprosthetic joint infections	19
Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future	18
The intersection of the laboratory and transgender care	18

Emerging applications of machine learning in genomic medicine and healthcare	18
Revisiting approaches to and considerations for urinalysis and urine culture reflexive testing	17
Therapeutic biomarkers in metastatic castration-resistant prostate cancer: does the state matter?	17
Methodological and conceptual challenges to the flow cytometric classification of leukemic lymphoproliferative disorders	16
The urocortin peptides: biological relevance and laboratory aspects of UCN3 and its receptor	15
General features, pathogenesis, and laboratory diagnostics of autoimmune encephalitis	15
Insight into metabolic dysregulation of polycystic ovary syndrome utilizing metabolomic signatures: a narrative review	14
Circulating tumor DNA (ctDNA): can it be used as a pan-cancer early detection test?	14
DNA/RNA-based electrochemical nanobiosensors for early detection of cancers	13
Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)	13
From fructose to the future: liver disease biomarkers and their prognostic value in acute liver failure	13
Effects of age, sex, serostatus, and underlying comorbidities on humoral response post-SARS-CoV-2 Pfizer-BioNTech mRNA vaccination: a systematic review	13
Advances in internal quality control	12
Erroneous potassium results: preanalytical causes, detection, and corrective actions	12
Point of care blood glucose devices in the hospital setting	12
Free thyroxine measurement in clinical practice: how to optimize indications, analytical procedures, and interpretation criteria while waiting for global standardization	12
Genotype-phenotype correlation in the spectrum of frontotemporal dementia-parkinsonian syndromes and advanced diagnostic approaches	11
Systematic review and meta-analysis of C-reactive protein as a biomarker in breast cancer	11
Research progress of KL-6 in respiratory system diseases	11
Establishing, evaluating and monitoring analytical quality in the traceability era	11
Genetic variants of accessory proteins and G proteins in human genetic disease	11
The multidimensional value of natriuretic peptides in heart failure, integrating laboratory and clinical aspects	11
Omics-based novel strategies in the diagnosis of endometriosis	10
Design, optimization, and application of multiplex rRT-PCR in the detection of respiratory viruses	10
Correction	10
Clinical utility of procalcitonin and its association with pathogenic microorganisms	10
Von Willebrand factor and disease: a review for laboratory professionals	9
Biomarkers of disease in human nails: a comprehensive review	9
Estimating glomerular filtration rate with new equations: can one size ever fit all?	9
Pre-analytical conditions and implementation of quality control steps in liquid biopsy analysis	8
The COVID-19 pandemic: viral variants and vaccine efficacy	8
From population-based to personalized laboratory medicine: continuous monitoring of individual laboratory data with wearable biosensors	6
Screening and diagnosis of inherited platelet disorders	6
Unveiling Parkinson’s disease through biomarker research: current insights and future prospects	6
Pathologist workload, burnout, and wellness: connecting the dots	6
Analytical performance specifications and quality assurance of point-of-care testing in primary healthcare	6
T helper cells in depression: central role of Th17 cells	6
Beyond the amyloid hypothesis: how current research implicates autoimmunity in Alzheimer’s disease pathogenesis	6
Implementation of pharmacogenomics testing for precision medicine	6
The current state in liquid chromatography-mass spectrometry methods for quantifying kynurenine pathway metabolites in biological samples: a systematic review	6
The role of immunophenotyping in common variable immunodeficiency: a narrative review	5
Implication of calcium supplementations in health and diseases with special focus on colorectal cancer	5
Advances in minimal residual disease monitoring in multiple myeloma	5
Preterm labor tests: current status and future directions	4
The significance of antigen-antibody-binding avidity in clinical diagnosis	4
Technical quality assurance and quality control for medical laboratories: a review and proposal of a new concept to obtain integrated and validated QA/QC plans	4
Laboratory test utilization and effect on clinical outcomes in a pediatric setting	4
The European Organisation of External Quality Assurance Providers in Laboratory Medicine (EQALM) Statement: guidelines for publishing about interlaboratory comparison studies (PubILC)	4
Procalcitonin for individualizing antibiotic treatment: an update with a focus on COVID-19	4
Reference intervals: past, present, and future	4

Modern techniques used in the diagnosis of autoimmune rheumatic diseases	4
Current status in cellular-based therapies for prevention and treatment of COVID-19	4
Lipid-binding antiphospholipid antibodies: significance for pathophysiology and diagnosis of the antiphospholipid syndrome	4
Machine learning models for acute kidney injury prediction and management: a scoping review of externally validated studies	4
G protein-coupled receptor (GPCR) gene variants and human genetic disease	4
Hereditary Micro‑Satellite Instable cancers associated with Lynch Syndrome: predictive biomarkers and novel immuno-therapeutic approaches	4