OOIR: Observatory of International Research

Papers

(The median citation count of Critical Reviews in Clinical Laboratory Sciences is 5. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
The anion gap as a predictive tool for morbidity and mortality	147
Deep learning algorithms and Raman spectroscopy in the clinical laboratory setting	72
Advances and challenges in the measurement of 1,25-dihydroxyvitamin D: a comprehensive review	61
Data analytics for error detection in clinical laboratories	48
Breathing new life into clinical testing and diagnostics: perspectives on volatile biomarkers from breath	44
Lipoprotein(a): a genetically determined risk factor for Cardiovascular disease	41
Machine learning-based error detection in the clinical laboratory: a critical review	40
Human telomere length detected by quantitative fluorescent in situ hybridization: overlooked importance and application	37
Transthyretin mutagenesis: impact on amyloidogenesis and disease	36
The therapeutic relevance of the Kallikrein-Kinin axis in SARS-cov-2-induced vascular pathology	33
Copeptin as a surrogate marker for arginine vasopressin: analytical insights, current utility, and emerging applications	33
Evaluating thyroid function in pregnant women	31
Clinical utility of human epididymis protein 4	28
Cardiovascular disease lipids and lipoproteins biomarker standardization	27
Beyond newborn screening: the role of reverse cascade testing in familial disease detection	26
KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis as biomarker	25
Guidance for securing approvals for new biomarkers: from discovery to clinical implementation	25
The molecular structure and biological functions of RNA methylation, with special emphasis on the roles of RNA methylation in autoimmune diseases	22
It’s in the blood: a review of the hematological system in SARS-CoV-2-associated COVID-19	22
Development of next-generation reference interval models to establish reference intervals based on medical data: current status, algorithms and future consideration	22
Challenges of insulin-like growth factor-1 testing	19
Analytical and clinical considerations of synovial fluid calprotectin in diagnosing periprosthetic joint infections	19
Association of inflammatory biomarkers with morbidity and mortality risk in patients with peripheral artery disease: a systematic review and meta-analysis	19
Emerging applications of machine learning in genomic medicine and healthcare	18
Choice of SARS-CoV-2 diagnostic test: challenges and key considerations for the future	17

Therapeutic biomarkers in metastatic castration-resistant prostate cancer: does the state matter?	16
Using a systematic approach to strategic innovation in laboratory medicine to bring about change	16
Pleural fluid biomarkers for the diagnosis and management of malignant pleural effusions: a clinical review	16
The intersection of the laboratory and transgender care	15
Methodological and conceptual challenges to the flow cytometric classification of leukemic lymphoproliferative disorders	15
General features, pathogenesis, and laboratory diagnostics of autoimmune encephalitis	14
The urocortin peptides: biological relevance and laboratory aspects of UCN3 and its receptor	14
Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL)	13
Guidelines for diagnosing and differentiating infection with antifungal-resistant Trichophyton indotineae from other dermatophytoses	13
Effects of age, sex, serostatus, and underlying comorbidities on humoral response post-SARS-CoV-2 Pfizer-BioNTech mRNA vaccination: a systematic review	13
Point of care blood glucose devices in the hospital setting	12
Free thyroxine measurement in clinical practice: how to optimize indications, analytical procedures, and interpretation criteria while waiting for global standardization	12
Circulating tumor DNA (ctDNA): can it be used as a pan-cancer early detection test?	12
Systematic review and meta-analysis of C-reactive protein as a biomarker in breast cancer	12
The multidimensional value of natriuretic peptides in heart failure, integrating laboratory and clinical aspects	12
Insight into metabolic dysregulation of polycystic ovary syndrome utilizing metabolomic signatures: a narrative review	12
DNA/RNA-based electrochemical nanobiosensors for early detection of cancers	12
Advances in internal quality control	12
From fructose to the future: liver disease biomarkers and their prognostic value in acute liver failure	11
Erroneous potassium results: preanalytical causes, detection, and corrective actions	11
Establishing, evaluating and monitoring analytical quality in the traceability era	11
Genotype-phenotype correlation in the spectrum of frontotemporal dementia-parkinsonian syndromes and advanced diagnostic approaches	10
Genetic variants of accessory proteins and G proteins in human genetic disease	10
Research progress of KL-6 in respiratory system diseases	9
Omics-based novel strategies in the diagnosis of endometriosis	8
Von Willebrand factor and disease: a review for laboratory professionals	7
Analytical performance specifications and quality assurance of point-of-care testing in primary healthcare	7
Design, optimization, and application of multiplex rRT-PCR in the detection of respiratory viruses	7
Biomarkers of disease in human nails: a comprehensive review	7
Pre-analytical conditions and implementation of quality control steps in liquid biopsy analysis	7
Correction	7
Estimating glomerular filtration rate with new equations: can one size ever fit all?	7
Pathologist workload, burnout, and wellness: connecting the dots	7
Screening and diagnosis of inherited platelet disorders	6
Unveiling Parkinson’s disease through biomarker research: current insights and future prospects	6
Implementation of pharmacogenomics testing for precision medicine	6
From population-based to personalized laboratory medicine: continuous monitoring of individual laboratory data with wearable biosensors	6
Advances in minimal residual disease monitoring in multiple myeloma	6
Loop-mediated isothermal amplification (LAMP)-based microbial detection: a review of FDA-authorized tests and future perspectives	6
Large scale implementation of DP for clinical diagnoses: experience, challenges, and lessons learned	6
The current state in liquid chromatography-mass spectrometry methods for quantifying kynurenine pathway metabolites in biological samples: a systematic review	6
Implication of calcium supplementations in health and diseases with special focus on colorectal cancer	6
Beyond the amyloid hypothesis: how current research implicates autoimmunity in Alzheimer’s disease pathogenesis	6
Preterm labor tests: current status and future directions	5
Current status in cellular-based therapies for prevention and treatment of COVID-19	5
Machine learning models for acute kidney injury prediction and management: a scoping review of externally validated studies	5
The role of immunophenotyping in common variable immunodeficiency: a narrative review	5
The European Organisation of External Quality Assurance Providers in Laboratory Medicine (EQALM) Statement: guidelines for publishing about interlaboratory comparison studies (PubILC)	5