Critical Reviews in Oncology Hematology

Article	Citations
Research update for ferroptosis and cholangiocarcinoma	165
Genomic biology and therapeutic strategies of liver metastasis from gastric cancer	153
Development of treatment strategies for advanced HER2-positive gastric cancer: Insights from clinical trials	128
Impact of molecular testing on the surgical management of advanced epithelial ovarian cancer	120
Factors for a broad technology assessment of comprehensive genomic profiling in advanced cancer, a systematic review	102
Editorial Board	93
HER2-targeted therapies: Unraveling their role in biliary tract cancers	79
Molecular biomarkers in prostate cancer tumorigenesis and clinical relevance	77
The role of hyperthermia in the treatment of tumor	73
Hurrying up but not rushing, acting and not reacting, good sense and not common sense: Open thoughts and reasonable doubts on COVID-19 vaccination strategies in cancer patients	66
The applications of plasma cell-free DNA in cancer detection: Implications in the management of breast cancer patients	64
What is the role of physical exercise in the era of cancer prehabilitation? A systematic review	59
Multigenic panels in breast cancer: Clinical utility and management of patients with pathogenic variants other than BRCA1/2	58
Management of bone disease with concurrent chimeric antigen receptor T-cell therapy for multiple myeloma	56
Targeted immunotherapy to cancer stem cells: A novel strategy of anticancer immunotherapy	55
Colorectal cancer with BRAF V600E mutation: Trends in immune checkpoint inhibitor treatment	55
Recent strategies to overcome breast cancer resistance	53
STAT3 orchestrates immune dynamics in hepatocellular carcinoma: A pivotal nexus in tumor progression	53
Application of molecular imaging in immune checkpoints therapy: From response assessment to prognosis prediction	50
Current status of locally advanced rectal cancer therapy and future prospects	50
Targeting androgen receptor in glioblastoma	50
Comprehensive approach to cancer immunotherapy – Simultaneous targeting of myeloid-derived suppressor cells and cancer cells with AFP conjugates	49
Immune checkpoint inhibitors therapy as the game-changing approach for pediatric lymphoma: A brief landscape	48
Geriatric predictors of response and adverse events in older patients with cancer treated with immune checkpoint inhibitors: A systematic review	48
Progress and prospects of flattening filter free beam technology in radiosurgery and stereotactic body radiotherapy	47

Real-world evidence in extensive disease small cell lung cancer: The missing piece of the puzzle	45
Adjuvant chemotherapy after neoadjuvant chemo-radiotherapy and surgery in locally advanced rectal cancer. A systematic review of literature with a meta-analysis of randomized clinical trials	45
Targeting mitochondrial dysfunctions in pancreatic cancer evokes new therapeutic opportunities	45
Evaluation of first-line and salvage therapies for unresectable malignant mesothelioma: A systematic review and network meta-analysis	43
From preclinical efficacy to 2022 (36.7 months median follow -up) updated CROWN trial, lorlatinib is the preferred 1st-line treatment of advanced ALK+ NSCLC	43
The role of PARP inhibitors in gastrointestinal cancers	40
Dose and volume de-escalation of radiotherapy in head and neck cancer	39
A Systematic Review on Intensity Modulated Radiation Therapy for Mediastinal Hodgkin’s Lymphoma	38
Comprehensive review of solid tumor bone marrow metastasis	38
Overcoming barriers to timely recognition and treatment of cancer cachexia: Sharing Progress in Cancer Care Task Force Position Paper and Call to Action	37
Theragnostic strategies harnessing the self-renewal pathways of stem-like cells in the acute myeloid leukemia	37
High dose chemotherapy followed by autologous hematopoietic stem cell transplantation for advanced germ cell tumors: State of the art and a single-center experience	36
Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: A systematic review and meta-analysis of randomized trials	36
Navigating management of localized prostate cancer in the geriatric population	35
Thrombotic microangiopathy (aHUS/iTTP) reported so far in Covid-19 patients: The virus alone or an omnium gatherum of mechanisms and etiologies?	35
Thoracic re-irradiation with 3D-conformal or more advanced techniques: A systematic review of treatment safety by the Re-irradiation Study Group of the Italian Association of Radiation and Oncology AI	35
Harnessing tumor metabolism during cancer treatment: A narrative review of emerging dietary approaches	34
BRAF-mutated colorectal adenocarcinomas: Pathological heterogeneity and clinical implications	33
Enhancing breast cancer surgery outcomes: A comprehensive review of oncoplastic techniques, surgical planning, and aesthetic considerations	33
A meta-analysis of palifermin efficacy for the management of oral mucositis in patients with solid tumours and haematological malignancy	32
The prevalence of solid tumors and hematologic malignancies among patients with Down syndrome: A systematic review and meta-analysis	31
BCMA CAR-T induces complete and durable remission in plasmablastic lymphoma synchronous transformation of chronic lymphocytic leukemia: Case report and literature review	31
Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy	31
Skin barrier dysfunction in cutaneous T-cell lymphoma: From pathogenic mechanism of barrier damage to treatment	31
Patient reported outcomes in the daily practice in clinical oncology: A systematic review	30
Chemotherapy for advanced gallbladder cancer (GBC): A systematic review and meta-analysis	30
Dynamics of eligibility criteria for central nervous system metastases in non-small cell lung cancer randomized clinical trials over time: A systematic review	29
Insights into the molecular roles of FOXR2 in the pathology of primary pediatric brain tumors	28
Outcomes with allogeneic hematopoietic stem cell transplantation in TP53-mutated myelodysplastic syndrome: A systematic review and meta-analysis	28
Potential agnostic role of BRCA alterations in patients with several solid tumors: One for all, all for one?	28
Letter to the Editor regarding the article “A net-work meta-analysis of the cardiac safety for next-generation hormonal agents in treating castration-resistant prostate cancer: How to choose drugs app	28
DCLK1 and tuft cells: Immune-related functions and implications for cancer immunotherapy	27
Maintenance strategies after anti-EGFR-based induction in metastatic colorectal cancer: A systematic review and bayesian network meta-analysis	27
Editorial Board	27
Working tables on Hormone Receptor positive (HR+), Human Epidermal growth factor Receptor 2 negative (HER2-) early stage breast cancer: Defining high risk of recurrence	27
Postoperative treatment of intermediate-risk early stage cervical cancer: results of a survey from the Gynecology Study Group in the AIRO Gyn and MITO Groups	26
Editorial Board	26
Editorial Board	26
Editorial Board	26
Network meta-analysis of palliative treatments in patients with esophageal cancer	26
Editorial Board	26
Editorial Board	26
Brain metastases and next-generation anticancer therapies: a survival guide for clinicians	25
Comment on “A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma”	25
Editorial Board	25
Clinical evidence and adverse event management update of patients with RET- rearranged advanced non-small-cell lung cancer (NSCLC) treated with pralsetinib	25
Epigenetics in advanced renal cell carcinoma: Potential new targets	24
Editorial Board	24
Total neoadjuvant treatment and organ preservation strategies in the management of localized rectal cancer: A narrative review and evidence-based algorithm	24
Gut and local microbiota in patients with cancer: increasing evidence and potential clinical applications	24

Neoadjuvant immunotherapy in head and neck cancer: Rationale, current evidence and future perspective	24
A bone paradigm challenging the standard model of myeloma oncogenesis	24
Editorial Board	24
Letter to the Editor regarding the article “Prognostic significance of SF3B1 mutations in patients with myelodysplastic syndromes: A meta-analysis”	24
The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies	24
Real-world insights into the efficacy and safety of tyrosine kinase inhibitors against thyroid cancers	24
Is antibody-drug conjugate a rising star for clinical treatment of solid tumors? A systematic review and meta-analysis	24
Novel insights of acute myeloid leukemia with CEBPA deregulation: Heterogeneity dissection and re-stratification	24
Survival and toxicity of weekly cisplatin chemoradiotherapy versus three-weekly cisplatin chemoradiotherapy for head and neck cancer: A systematic review and meta-analysis endorsed by the Italian Asso	23
Treatment strategies for locally advanced non-small cell lung cancer in elderly patients: Translating scientific evidence into clinical practice	23
Perioperative chemotherapy versus adjuvant chemotherapy in patients with resectable gastric cancer: A systematic review with meta-analysis	22
C-reactive protein (CRP) as a prognostic biomarker in patients with urothelial carcinoma: A systematic review and meta-analysis	22
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib	22
The management of oligometastatic disease in colorectal cancer: Present strategies and future perspectives	22
Radiation therapy, tissue radiosensitization, and potential synergism in the era of novel antibody-drug conjugates	22
Inhibition of acetylation, is it enough to fight cancer?	22
Treatment of melanoma brain metastases with radiation and immunotherapy or targeted therapy: A systematic review with meta-analysis	22
Recent approaches for the treatment of uveal melanoma: Opportunities and challenges	21
Faecal immunochemical tests can improve colonoscopy triage in patients with iron deficiency: A systematic review and meta-analysis	21
cGAS-STING at the crossroads in cancer therapy	21
Standard Operating Procedures (SOPs) for non-invasive multiple biomarkers detection in an academic setting: A critical review of the literature for the RENOVATE study protocol	21
Navigating immune cell immunometabolism after liver transplantation	21
Integrating hereditary breast and ovarian cancer genetic counselling and testing into mainstream clinical practice: Legal and ethical challenges	21
Microbiome and lung cancer: carcinogenic mechanisms, early cancer diagnosis, and promising microbial therapies	21
A non-invasive miRNA-based approach in early diagnosis and therapeutics of oral cancer	21
Filgrastim biosimilar (EP2006): A review of 15 years’ post-approval evidence	21
Direct and indirect effects on child neurocognitive development when maternal cancer is diagnosed during pregnancy: What do we know so far?	21
Hematopoietic stem cell stretches and moves in its bone marrow niche	21
Circular RNAs and thyroid cancer: Closed molecules, open possibilities	21
Preoperative treatments in borderline resectable and locally advanced pancreatic cancer: Current evidence and new perspectives	21
The intestinal microbiota in colorectal cancer metastasis – Passive observer or key player?	21
The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth	21
DNA methylation in oral squamous cell carcinoma: from its role in carcinogenesis to potential inhibitor drugs	21
Nrf2--a hidden bridge linking cancer stem cells to ferroptosis	21
Gene expression signatures in older patients with breast cancer: A systematic review	21
Open issues in the therapeutic management of unresectable stage III NSCLC in the immunotherapy era	20
Lymph node metastasis in cancer: Clearing the clouds to see the dawn	20
The storm of NGS in NSCLC diagnostic-therapeutic pathway: How to sun the real clinical practice	20
Double agents in immunotherapy: Unmasking the role of antibody drug conjugates in immune checkpoint targeting	20
Comparison of the efficacy and safety of first-line treatments based on clinicopathological characteristics for patients with advanced epidermal growth factor receptor mutated non-small-cell lung canc	20
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target	20
KRAS mutations in advanced non-small cell lung cancer: From biology to novel therapeutic strategies	20
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part II	20
Efficacy of PD-1/PD-L1 immunotherapy on brain metastatic non-small-cell lung cancer and treatment-related adverse events: A systematic review	20
Corrigendum to “Navigating the complexity of PI3K/AKT pathway in HER-2 negative breast cancer: Biomarkers and beyond” [Crit. Rev. Oncol./Hematol. 200C (2024) 104404]	19
Donor-derived and off-the-shelf allogeneic anti-CD19 CAR T-cell therapy for R/R ALL and NHL: A systematic review and meta-analysis	19
Corrigendum to “Prevalence of treatment-related adverse events (TRAEs) with antibody-drug conjugates in metastatic breast cancer patients: A systematic review and meta-analysis” [Crit. Rev. Oncol./Hem	19
The application of cancer stem cell model in malignant mesothelioma	19
Effectiveness of low level laser therapy versus cryotherapy in cancer patients with oral mucositis: Systematic review and network meta-analysis	19
Instruments and scales for the evaluation of acute radiation dermatitis: A systematic review	19
Exosome-based advances in pancreatic cancer: The potential of mesenchymal stem cells	18
Patients’ selection and trial matching in early-phase oncology clinical trials	18
Current management of cervical cancer in women living with HIV	18
Advancing patient setup: A comprehensive scoping review of tattoo-less techniques in radiation therapy	18
International consensus on the initial diagnostic workup of cancer of unknown primary	18
Outcomes in randomized controlled trials of therapeutic interventions for multiple myeloma: A systematic review	18
Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics	18
Tumor budding is a prognostic factor in head and neck squamous cell carcinoma: A comprehensive meta-analysis and trial sequential analysis	18
Clonal hematopoiesis and inflammation: A review of mechanisms and clinical implications	18
A clinical evaluation of robotic-assisted radical prostatectomy (RARP) in located prostate cancer: A systematic review and network meta-analysis	18
Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance	17
How much is too much? Systematic review of cumulative doses from radiological imaging and the risk of cancer in children and young adults	17
Management of acute spinal cord compression in multiple myeloma	17
A systematic review and meta-analysis of trials assessing PD-1/PD-L1 immune checkpoint inhibitors activity in pre-treated advanced stage malignant mesothelioma	17
The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognoses	17
Factor Xa inhibitors versus low molecular weight heparin for the treatment of cancer associated venous thromboembolism; A meta-analysis of randomized controlled trials and non-randomized studies	17
Improving the multidisciplinary therapeutic management of head and neck squamous cell carcinoma: consensus statements from an Italian expert panel	17
Nano based-oncolytic viruses for cancer therapy	17
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models	17
Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study	17
The 2022 Assisi Think Tank Meeting: White paper on optimising radiation therapy for breast cancer	16
Cell signaling pathways as molecular targets to eliminate AML stem cells	16
Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions	16
Recent insights into the role of the microbiome in malignant and benign hematologic diseases	16
Neoadjuvant chemotherapy in hormone receptor-positive/HER2-negative early breast cancer: When, why and what?	16
Trastuzumab deruxtecan in breast cancer	16
Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis	16
Definitive radiotherapy and trismus in HNC patients: A critical review	15
Chronic pain management in sickle cell disease: A systematic scoping review of controlled trials	15
Clinical pharmacology and drug-drug interactions of lenvatinib in thyroid cancer	15

UGT1A1 Testing in Breast Cancer: should it become routine practice in patients treated with antibody-drug conjugates?	15
Diagnosis and treatment of therapy-related acute myeloid leukemia	15
Paraneoplastic syndromes review: The great forgotten ones	15
Head and neck squamous cell carcinoma: Exploring frontiers of combinatorial approaches with tyrosine kinase inhibitors and immune checkpoint therapy	15
Long non-coding RNA and the tumor microenvironment: Prospects for clinical applications in breast cancer	15
Live European School of Oncology e-Sessions (e-ESO)	15
Long noncoding RNA expression in acute lymphoblastic leukemia: A systematic review	15
Unlocking the intricacies: Exploring the complex interplay between platelets and ovarian cancer	15
Management of secondary immunodeficiency in hematological malignancies in the era of modern oncology	15
Special features of sarcomas developed in patients with Lynch syndrome: A systematic review	15
Bacteria-driven cancer therapy: Exploring advancements and challenges	15
Biopsychosocial factors related to transition among adolescents and young adults with sickle cell disease: A systematic review	15
Potential therapeutic targets in myeloid cell therapy for overcoming chemoresistance and immune suppression in gastrointestinal tumors	15
Third-line treatment and beyond in metastatic colorectal cancer: What do we have and what can we expect?	15
An empirical review on the resistance mechanisms of epidermal growth factor receptor inhibitors and predictive molecular biomarkers in colorectal cancer	14
A systematic review and meta-analysis of adjuvant chemotherapy after chemoradiation for locally advanced cervical cancer	14
Editorial Board	14
Exploring biological heterogeneity and implications on novel treatment paradigm in BRAF-mutant metastatic colorectal cancer	14
The optimal timing between neoadjuvant therapy and surgery of breast cancer: A brief systematic review of the literature	14
Editorial Board	14
Editorial Board	14
Editorial Board	14
Editorial Board	14
ESO's career development program (2002-2021): Presentation and evaluation	14
Incidence of antibody–drug conjugate-related fatigue in patients with breast cancer: A systematic review and meta-analysis	14
Perioperative imaging predictors of tumor progression and pseudoprogression: A systematic review	14
Editorial Board	14
Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis	14
Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: A systematic review and meta-analysis	14
Targeting TRK: A fast-tracked application of precision oncology and future directions	14
Optimal treatment strategy for central nervous system non-germinomatous germ cell tumors: A systematic review and meta-analysis	13
Clinical benefit of immune checkpoint inhibitors in elderly cancer patients: Current evidence from immunosenescence pathophysiology to clinical trial results	13
Therapeutic sequencing in advanced renal cell carcinoma: How to choose considering clinical and biological factors	13
Role of the International Society of Liquid Biopsy (ISLB) in establishing quality control frameworks for clinical integration	13
Effectiveness and safety of immune checkpoint inhibitors in combination with palliative radiotherapy in advanced melanoma: A systematic review	13
Meta-analysis of immune-related adverse events in phase 3 clinical trials assessing immune checkpoint inhibitors for lung cancer	13
Natural killer cells at the forefront of cancer immunotherapy with immune potency, genetic engineering, and nanotechnology	13
Cellular senescence in tumor immune escape: Mechanisms, implications, and therapeutic potential	13
131I-mIBG therapy in relapsed/refractory neuroblastoma: A weapon from the future past	13
Editorial Board	13
Exploring pulmonary function and physical function in childhood cancer: A systematic review	13
P16 gene promoter methylation is associated with oncogenesis and progression of gastric carcinomas: A systematic review and meta-analysis	13
Immune checkpoint inhibitors combined with HER-2 targeted therapy in HER-2 positive gastroesophageal cancer	13
Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules	13
Small cell lung cancer unveiled: Exploring the untapped resource of circulating tumor cells-derived organoids	13
Cellular and molecular mechanisms implicated in the dual role of ROR2 in cancer	13
Infections in haematology patients treated with CAR-T therapies: A systematic review and meta-analysis	13
Next-generation sequencing for PTEN testing in HR+/HER2˗ metastatic breast cancer	13
Effect of exercise on functional capacity in patients with advanced cancer: A meta-analysis of randomized controlled trials	12
Comment on “The risk of breast cancer and gynecologic malignancies after ovarian stimulation: Meta-analysis of cohort study”	12
Uncommon targets in non-small cell lung cancer: Everyone wants a slice of cake	12
Managing side effects of immune checkpoint inhibitors in breast cancer	12
Low-risk triple-negative breast cancers: Clinico-pathological and molecular features	12
Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy	12
Understanding mechanisms of resistance to FLT3 inhibitors in adult FLT3-mutated acute myeloid leukemia to guide treatment strategy	12
Clinical implications of the Drug-Drug Interaction in Cancer Patients treated with innovative oncological treatments	12
Association of PD-L1 expression with survival benefit from PD-1/PD-L1 inhibitors in advanced cancer: Systematic review and meta-analysis of phase III randomized clinical trials	12
Prognostic value of platelet-related measures for overall survival in esophageal squamous cell carcinoma: A systematic review and meta-analysis	12
Thromboembolic risk in prostate cancer patients treated with PARP inhibitors: A systematic review and meta-analysis	12
Optimizing CDK4/6 inhibitors in advanced HR+/HER2- breast cancer: A personalized approach	12
Patient reported outcome measure domains and tools used among adolescents and young adults with cancer: A scoping review	12
Unlocking Hope: Anti-VEGFR inhibitors and their potential in glioblastoma treatment	12
Adjuvant therapy for renal cell carcinoma: A systematic review of current landscape and future directions	12
Immunologic disparities in prostate cancer between American men of African and European descent	12
Advancements in tumor-infiltrating lymphocytes: Historical insights, contemporary milestones, and future directions in oncology therapy	11
Systematic review of randomised clinical trials and observational studies for patients with RAS wild-type or BRAF-mutant metastatic and/or unresectable colorectal cancer	11
Current mRNA-based vaccine strategies for glioma treatment	11
Which treatment after first line therapy in NSCLC patients without genetic alterations in the era of immunotherapy?	11
Brain metastasis: An insight into novel molecular targets for theranostic approaches	11
New options and open issues in the management of unresectable stage III and in early-stage NSCLC: A report from an expert panel of Italian medical and radiation oncologists – INTERACTION group	11
Thrombosis and cachexia in cancer: Two partners in crime?	11
TIGIT: Will it be the next star therapeutic target like PD-1 in hematological malignancies?	11
Potential role of cGAS/STING pathway in regulating cancer progression	11
Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach	11
Cutaneous adverse events associated with immune checkpoint blockade: A systematic review and meta-analysis	11
Diagnosis and treatment of cholangiocarcinoma in Italy: A Delphi consensus statement	11
Tissue and circulating PD-L2: moving from health and immune-mediated diseases to head and neck oncology	11
Effects of mindfulness-based interventions on fatigue in cancer survivors: A systematic review and meta-analysis of randomized controlled trials	11
Prognostic factors in salvage surgery for recurrent head and neck cancer: A systematic review and meta-analysis	11
Progress in the treatment of malignant ascites	11
Bladder-sparing treatment for muscle-invasive bladder carcinoma using immune checkpoint inhibitors	11
Targeting pediatric solid tumors in the new era of RNA therapeutics	11
Pressurised intraperitoneal aerosolised chemotherapy (PIPAC) for gastric cancer with peritoneal metastases: A systematic review by the PIPAC UK collaborative	11
Fertility counseling in women with hereditary cancer syndromes	11
Tumor plasticity and therapeutic resistance in oncogene-addicted non-small cell lung cancer: from preclinical observations to clinical implications	11
Prediction performance of twelve tumor mutation burden panels in melanoma and non-small cell lung cancer	11
Advantages and drawbacks of dexamethasone in glioblastoma multiforme	10
Advanced and recurrent endometrial cancer: State of the art and future perspectives	10
How safe and effective is irradiating radiation-induced meningiomas? Single-center experience in primary and salvage Gamma-Knife Radiosurgery, systematic review, and metanalysis of current evidence on	10
Immuno-oncology therapy in metastatic bladder cancer: A systematic review and network meta-analysis	10
Editorial Board	10
Treatment of brain metastases in ALK-positive non-small cell lung cancer	10
Targeting hypoxia-inducible factor pathways in sporadic and Von Hippel-Lindau syndrome-related kidney cancers	10
Involvement of CircRNAs in regulating The “New Generation of Cancer Hallmarks”: A Special Depiction on Hepatocellular Carcinoma	10
Targeting epigenetic mechanisms of resistance to chemotherapy in gliomas	10