Critical Reviews in Oncology Hematology

Papers
(The TQCC of Critical Reviews in Oncology Hematology is 12. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)
ArticleCitations
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part II341
Microbiome dynamics in breast cancer: Mechanisms, therapeutic impacts and research gaps219
Bidirectional role of neutrophils in lung cancer: Mechanisms and therapeutic implications172
A systematic review and meta-analysis of blood-based biomarkers in anal squamous cell cancer treated with chemoradiotherapy128
Skin barrier dysfunction in cutaneous T-cell lymphoma: From pathogenic mechanism of barrier damage to treatment109
Open issues in the therapeutic management of unresectable stage III NSCLC in the immunotherapy era106
Comparative efficacy of first-line therapies for PD-L1-negative advanced NSCLC: A network meta-analysis with reconstructed survival curves100
Double agents in immunotherapy: Unmasking the role of antibody drug conjugates in immune checkpoint targeting81
Editorial Board77
Beyond the blood-brain barrier: Intranasal vaccines in cancer immunotherapy70
Real-world analysis of primary central nervous system diffuse large B-cell lymphoma67
Efficacy of PD-1/PD-L1 immunotherapy on brain metastatic non-small-cell lung cancer and treatment-related adverse events: A systematic review66
Novel insight into the Warburg effect: Sweet temptation65
Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy62
The role of cGAS-STING in remodeling the tumor immune microenvironment induced by radiotherapy60
Current status of locally advanced rectal cancer therapy and future prospects59
The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth58
Direct and indirect effects on child neurocognitive development when maternal cancer is diagnosed during pregnancy: What do we know so far?54
A non-invasive miRNA-based approach in early diagnosis and therapeutics of oral cancer54
Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions53
Systemic immune-inflammation index as a predictor of survival in non-small cell lung cancer patients undergoing immune checkpoint inhibition: A systematic review and meta-analysis53
Letter to the Editor regarding the article “A net-work meta-analysis of the cardiac safety for next-generation hormonal agents in treating castration-resistant prostate cancer: How to choose drugs app52
Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis52
Microbiome and lung cancer: carcinogenic mechanisms, early cancer diagnosis, and promising microbial therapies49
Beyond monospecificity: The modular revolution of bispecific immunotherapeutics48
Spatial multiomics of the breast tumour microenvironment: State of the field, advancements and clinical implementation promises48
Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics47
Instruments and scales for the evaluation of acute radiation dermatitis: A systematic review45
Navigating management of localized prostate cancer in the geriatric population44
Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: A systematic review and meta-analysis of randomized trials42
Novel bioengineered drugs with immunotherapies for malignant pleural effusion: Remodulate tumor immune microenvironment and activate immune system41
Total neoadjuvant treatment and organ preservation strategies in the management of localized rectal cancer: A narrative review and evidence-based algorithm41
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models40
Targeted doublet therapy with encorafenib and cetuximab for BRAF V600E-mutant metastatic colorectal cancer: A systematic review and meta-analysis40
The hidden hand of endoplasmic reticulum stress in anticancer drug resistance40
Surface-Enhanced Raman Scattering (SERS) combined with machine learning enables accurate diagnosis of cervical cancer: From molecule to cell to tissue level40
Development of treatment strategies for advanced HER2-positive gastric cancer: Insights from clinical trials39
Harnessing tumor metabolism during cancer treatment: A narrative review of emerging dietary approaches39
Stereotactic body radiotherapy as an alternative to brachytherapy in cervical cancer (SCORE): A systematic review and meta-analysis39
Unveiling the Role of JAK2/STAT3 signaling in chemoresistance of gynecological cancers: From mechanisms to therapeutic implications38
From immunohistochemistry to machine learning-based patient stratification by tumour proliferation characteristics in head and neck cancer38
The BCL-2–tumor microenvironment axis: Mechanisms of immune suppression, resistance, and pathways to therapeutic reprogramming38
Trastuzumab deruxtecan: Redefining precision oncology across HER2-driven cancers37
First-line treatments for advanced or recurrent endometrial cancer: Systematic literature review of clinical evidence37
Targeting hypoxia-inducible factor pathways in sporadic and Von Hippel-Lindau syndrome-related kidney cancers37
Neoadjuvant therapy for muscle-invasive bladder cancer: Current clinical scenario, future perspectives, and unsolved questions37
cGAS–STING signaling pathway in urogenital oncology: Regulation, resistance, and routes to response36
Chemotherapy, immunotherapy, and targeted therapy for osteosarcoma: Recent advancements35
Editorial Board33
Comment on “The risk of breast cancer and gynecologic malignancies after ovarian stimulation: Meta-analysis of cohort study”33
Impact of adding immune checkpoint inhibitors to standard therapies in non-small cell lung cancer: A systematic review of efficacy outcomes32
The biology and treatment of leiomyosarcomas32
Histopathological ultrastaging of mesocolic lymph nodes after colon cancer resection: A systematic review and meta-analysis32
Editorial Board32
UGT1A1 Testing in Breast Cancer: should it become routine practice in patients treated with antibody-drug conjugates?32
Predictive factors for return to work among cancer survivors in Europe: A systematic review31
Optimal treatment strategy for central nervous system non-germinomatous germ cell tumors: A systematic review and meta-analysis31
Comparative analysis of systemic treatment with or without immune checkpoint inhibitors for advanced or recurrent endometrial cancer: A systematic review and meta-analysis of randomized controlled tri31
TIGIT: Will it be the next star therapeutic target like PD-1 in hematological malignancies?30
The role of GPI-anchored LY6/uPAR family proteins in connecting membrane microdomains with immune regulation and diseases30
Prognostic value of HER2 discordance between primary and metastatic or recurrent breast cancer: A systematic review and meta-analysis30
Pressurised intraperitoneal aerosolised chemotherapy (PIPAC) for gastric cancer with peritoneal metastases: A systematic review by the PIPAC UK collaborative29
Next-generation immunotherapy in relapsed/refractory multiple myeloma: Strategies to achieve sustained MRD negativity29
Effect of exercise on functional capacity in patients with advanced cancer: A meta-analysis of randomized controlled trials29
Adjuvant immunotherapy in high-risk renal cell carcinoma: Indications, limitations, and perspectives. A consensus statement from the GIOTTO uro-oncology group28
Management of secondary immunodeficiency in hematological malignancies in the era of modern oncology28
Androgen receptor as a prognostic biomarker in breast cancer: A systematic review and meta-analysis28
Thrombosis and cachexia in cancer: Two partners in crime?27
KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics27
The critical role of epithelial-mesenchymal transition (EMT) in colorectal cancer progression and therapeutic outcomes27
Predictive models for immune checkpoint inhibitor response in cancer: A review of current approaches and future directions27
Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy27
Clinical trials for patients with salivary gland cancers: A systematic review of worldwide registers and an evaluation of current challenges26
Immunotherapy in OSCC: Current trend and challenges26
Quantifying absolute benefit for adjuvant treatment options in renal cell carcinoma: A living interactive systematic review and network meta-analysis26
Efficacy of stereotactic radiosurgery as single or combined therapy for brain metastasis: A systematic review and meta-analysis26
Synergistic effects of immunotherapy and adjunctive therapies in prostate cancer management26
Challenges facing CAR T-cell immunotherapy in multiple myeloma26
Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors26
The role and clinical significance of tumor-draining lymph nodes in tumor progression and immunotherapy26
Editorial Board26
Efficacy and safety of targeted therapy and immunotherapy in advanced vulvar squamous cell carcinoma: A scoping review26
Antibody-Drug Conjugates in urothelial, prostate, and renal cell cancers: A review of current and emerging therapies26
Unveilling the potential of liquid biopsy in pancreatic cancer for molecular diagnosis and treatment guidance26
Unlocking the potential of Molecular Tumor Boards: from cutting-edge data interpretation to innovative clinical pathways26
A comprehensive review on targeting diverse immune cells for anticancer therapy: Beyond immune checkpoint inhibitors25
Liposomal nanocarriers in precision oncology: Advances and prospects25
The safety and effectiveness of hypofractionated radiotherapy for localized prostate cancer: A systematic review and meta-analysis25
Antibody-oligonucleotide conjugates in cancer therapy: Potential and Promise25
Unraveling molecular mechanisms of head and neck cancer25
DLL3 as a potential diagnostic and therapeutic target in neuroendocrine neoplasms: A narrative review25
Neoadjuvant therapy in ovarian cancer: Emerging paradigms and therapeutic frontiers25
Minimal residual disease testing for classical Hodgkin lymphoma: A comprehensive review25
The role of liquid biopsy in epithelial ovarian cancer: State of the art25
CAR T-cell therapy landscape in pediatric, adolescent and young adult oncology – A comprehensive analysis of clinical trials24
The extracellular matrix in colorectal cancer and its metastatic settling – Alterations and biological implications24
The role of central nervous system (CNS) prophylaxis in preventing DLBCL patients from CNS relapse: A network meta-analysis24
The peripheral tumor neuro-microenvironment: Deciphering neural landscape and mechanistic insights for therapeutic innovation24
Editorial Board23
Decoding the puzzle: A multidisciplinary systematic review of adult brainstem glioma23
The association between paraneoplastic neurological syndromes (PNS) and urothelial carcinoma – A review of the literature23
Unlock the code of MHC II-enabled Cancer immunotherapy23
Role of radiation in chimeric antigen receptor T-cell therapy for patients with relapsed/refractory non-Hodgkin lymphoma: Current studies and future prospects23
Cardio-oncology concerns in radiotherapy: Heart and cardiac substructure toxicities from modern delivery techniques22
Plasmonic surgery: SERS-active smart nanotools reshaping intraoperative decision-making and precision therapy22
Towards a new approach in pleural mesothelioma: Perioperative immunotherapy and its implications22
Epigenetic mechanisms of PARP inhibitor resistance in ovarian cancer: A systematic review with bioinformatic analysis of clinically actionable genes22
Editorial Board22
Rethinking treatment paradigms: Neoadjuvant therapy and de-escalation strategies in HPV-positive head and neck cancer22
The pH perspective of cancer: From warburg's misconception to therapeutic targeting of pH regulating proteins22
Corrigendum to “A review of relative dose intensity and survival in patients with metastatic solid tumors” [Crit. Rev. Oncol. Hematol. 93 (2015) 203–210]22
RNA N4-acetylcytidine modification in gastrointestinal cancer: Novel functions, mechanisms, and therapeutic implications22
Pathology, immunosuppression and NK cell immunotherapy of non-small cell lung cancer21
Strategies to overcome chemoresistance in epithelial ovarian cancer: Navigating beyond challenges21
Salvage radiotherapy after initial cryotherapy for localized prostate cancer: A systematic review of the literature21
Revolutionizing immunotherapy: The next frontier in CAR T-cell engineering21
Long-term strategies for management of advanced basal cell carcinoma with hedgehog inhibitors21
Combining gut microbiota modulation and immunotherapy: A promising approach for treating microsatellite stable colorectal cancer21
Drug-based therapy for advanced adenoid cystic carcinoma: Current landscape and challenges based on an overview of registered clinical trials21
Sialylated glycoproteins and sialyltransferases in digestive cancers: Mechanisms, diagnostic biomarkers, and therapeutic targets20
Safety and efficacy of liposomal irinotecan as the second-line treatment for advanced pancreatic cancer: A systematic review and meta-analysis20
Recent advances and research progress in biomarkers for chronic graft versus host disease20
« Augmented radiotherapy » in the management of high-risk prostate cancer (PCa): A systematic review20
Recent development in bispecific antibody immunotherapy for hematological malignancies20
The novel roles of RNA 5-methylcytosine modification in gastrointestinal tract cancers20
Personalized medicine for metastatic prostate cancer: The paradigm of PARP inhibitors20
Comprehensive review of signaling pathways and therapeutic targets in gastrointestinal cancers20
Advancing CAR-T cell manufacturing in Latin America: Current landscape, future directions, and challenges20
From G12C To Pan-RAS: The Expanding Therapeutic Landscape of KRAS-Mutant NSCLC19
Bridging the translational gap in HNSCC immunotherapy: From resistance mechanisms to high-fidelity preclinical models19
IHC-based molecular classification in muscle-invasive urothelial bladder carcinoma: Prognostic and predictive value toward a clinically applicable IHC marker panel – A systematic review19
Testicular germ cell tumors: Genomic alternations and RAS-dependent signaling19
The diagnostic accuracy of single-item scales in detecting fatigue in patients with cancer: A systematic review and meta-analysis19
Facing the climate change: Is radiotherapy as green as we would like? A systematic review19
Targeting TIME in advanced hepatocellular carcinoma: Mechanisms of drug resistance and treatment strategies19
Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to lymphoma19
Elucidating the mechanistic role of ovarian cancer biomarkers: Lessons learnt from affinity-proteomics19
Artificial intelligence in NSCLC management for revolutionizing diagnosis, prognosis, and treatment optimization: A systematic review19
Epigenetic-modifying agents: The potential game changers in the treatment of hematologic malignancies19
NRG1 fusions:The potential targeted treatment in non-small cell lung cancer(NSCLC)19
Deciphering the possible reciprocal loop between hepatic stellate cells and cancer cells in the tumor microenvironment of the liver19
Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities19
Endometrial cancer in the elderly: Characteristics, prognostic and risk factors, and treatment options18
Prognostic value of CD49d in CLL: Systematic review and meta-analysis18
Uncovering the bookshelves of CRISPR-based libraries: Advances and applications in cancer studies18
Current landscape of hypoxia in thyroid cancer pathogenesis and treatment18
Molecular mechanisms of ferroptosis and its role in prostate cancer therapy18
Delta-like ligand 3 in small cell lung cancer: Potential mechanism and treatment progress18
Navigating chemotherapy and immunotherapy in early-stage lung cancer. A critical review and statements from INTERACTION group18
The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis18
Targeting breast cancer stem cells through retinoids: A new hope for treatment18
Rare histotypes of epithelial biliary tract tumors: A literature review18
Androgen annihilation versus advanced androgen blockage as first line treatment for metastatic castration resistant prostate cancer: A systematic review and meta-analysis18
Incidence of antibody–drug conjugates-related pneumonitis in patients with solid tumors: A systematic review and meta-analysis18
Molecular oncology of iodine refractory thyroid cancer current therapies and perspective18
Evaluation of clinical decision support systems in oncology: An updated systematic review18
Combine radiotherapy and immunotherapy in esophageal squamous cell carcinoma17
Biomarkers in blood and saliva to screen fragile patients with solid tumors: A systematic review of the literature17
Radiotherapy of high-grade gliomas: dealing with a stalemate17
The impact of survivorship bias in glioblastoma research17
Is it a new era for intrahepatic cholangiocarcinoma?17
Profile of treatment-related adverse events of PD-1 blockade-based therapies in advanced esophageal cancer: A systematic review and meta-analysis17
Radiosensitization strategies for hepatocellular carcinoma: Mechanisms, therapeutic advances, and clinical perspectives17
Management of patients with extensive small-cell lung cancer in the immunotherapy era: An Italian consensus through a Delphi approach17
Anticancer mechanisms and applications based on γδ T cells in cancer immunotherapy17
Role of innate immunity in tumor microenvironment of HPV-associated anal cancer: The hypothetical beneficial role of γδ T cells.17
The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis17
N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential17
Shaping immunotherapy through the tumor microenvironment: Translational perspectives17
Circular RNAs: A key modulator of established cancer hallmarks17
Editorial Board17
Editorial Board17
Evidence-based recommendations for induction and maintenance treatment of newly diagnosed transplant-ineligible multiple myeloma patients17
Next-Generation models of Gallbladder Carcinoma: Linking biological insights to precision medicine17
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer17
Immune checkpoint inhibitors as a threat to reproductive function: A systematic review17
Safety assessment of antibody-drug conjugates: Nonclinical toxicology, non-active ingredients, and environmental risk considerations17
Symptomatologic outcomes of gut microbiota modifiers (probiotics, prebiotics and synbiotics) in cancer care: A scoping review of randomized controlled trials17
The educational contribution of the college of the European school of oncology (ESCO): A survey analysis of the first three years17
Association between bevacizumab with cancer drug therapies and drug-induced interstitial lung disease in patients with solid tumor: A systematic review and meta-analysis of randomized clinical trials17
A neuroendocrine biomarker revolution from monoanalyte to multianalyte biomarkers in non-functioning gastro-entero-pancreatic neuroendocrine neoplasms16
TRAIL-functionalized nanoparticles in cancer therapy: Molecular mechanisms and translational opportunities16
Radioprotective agents against the ionizing radiation-induced hematopoietic stem and progenitor cell injury; Foundation review16
Outcome after treatment with axitinib in children, young adults, and adults with renal cell carcinoma: a narrative review16
Spatial transcriptomics in pancreatic cancer: Advances, prospects and challenges16
The role of the SIX family in cancer development and therapy: Insights from foundational and cutting-edge research16
Expanding horizons in cancer therapy by immunoconjugates targeting tumor microenvironments16
Extrachromosomal DNA in cancer: Molecular mechanisms underlying oncogene amplification and tumor heterogeneity16
Chimeric antigen receptor T cell immunotherapy for gynecological malignancies16
Polyploid giant cancer cells: Underlying mechanisms, signaling pathways, and therapeutic strategies16
Effect of non-pharmacological interventions on symptoms and quality of life in patients with hematological malignancies – A systematic review16
Additions and subtractions of radiotherapy in patients with oligometastatic non-small cell lung cancer under the era of immunotherapy16
Pseudogenes in breast cancer pathogenesis and their clinical utility16
Venetoclax and ibrutinib: Two partners for the front-line treatment of chronic lymphocytic leukemia16
Cardiovascular safety outcomes of chronic lymphocytic leukemia treatments: A systematic and targeted literature review16
Stereotactic body radiotherapy boost as an alternative to brachytherapy for cervical cancer: A scoping review16
The impact of PARP inhibitors in the whole scenario of ovarian cancer management: A systematic review and network meta-analysis16
Which is the best treatment for melanoma brain metastases? A Bayesian network meta-analysis and systematic review16
Neoadjuvant endocrine therapy for luminal breast tumors: State of the art, challenges and future perspectives16
Novel insights into UDP-glucuronosyltransferase 1A1 dysfunction and Gilbert’s syndrome on estrogen metabolism and breast cancer15
KRAS G12C-mutant driven non-small cell lung cancer (NSCLC)15
Somatic and germline ATM variants in non-small-cell lung cancer: Therapeutic implications15
Spread through air spaces in lung cancer: From controversy to consensus15
WEE1 inhibition in cancer therapy: Mechanisms, synergies, preclinical insights, and clinical trials15
Exploring the molecular interactions between ferroptosis and the Wnt/β-catenin signaling pathway: Implications for cancer and disease therapy15
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies15
Venous thromboembolism in cancer and cancer immunotherapy15
Status of breast cancer in Latin American: Results of the breast cancer revealed initiative15
The roles of immune cells and non-immune cells in pre-metastatic niche of breast cancer15
Significance of HOXD transcription factors family in progression, migration and angiogenesis of cancer15
Fatty acid in the tumor microenvironment: Perspectives for immunotherapy15
Neural stem cells and glioblastoma stem cells: Redefining concepts15
The influence of genetic variation on late effects in childhood cancer survivors: An updated systematic review15
Non-coding RNAs and liquid biopsies: Emerging biomarkers for cervical cancer15
Standardized molecular pathology workflow for ctDNA-based ESR1 testing in HR+/HER2- metastatic breast cancer15
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part I15
The study of primary and acquired resistance to first-line osimertinib to improve the outcome of EGFR-mutated advanced Non-small cell lung cancer patients: the challenge is open for new therapeutic st15
The application of stepped-wedge cluster-randomized controlled trial study designs in oncology settings: A systematic review15
Factors for a broad technology assessment of comprehensive genomic profiling in advanced cancer, a systematic review14
Comment on: Predictors of prognosis and overall survival in pediatric mucoepidermoid carcinoma of salivary glands14
Cardiac and vascular toxicity of amivantamab in non-small cell lung cancer (NSCLC): A systematic review14
The effects of race on anti-PD-(L)1 monoclonal antibodies in non-small cell lung cancer: A systematic literature review and meta-analysis14
Dynamic interplay of neuroendocrine signaling and immuno-surveillance in tumor niche remodeling14
The application of cancer stem cell model in malignant mesothelioma14
Erratum to “Beyond the blood-brain barrier: Intranasal vaccines in cancer immunotherapy” [Crit. Rev. Oncol./Hematol. 216C (2025) 104938]14
The prevalence of solid tumors and hematologic malignancies among patients with Down syndrome: A systematic review and meta-analysis14
International consensus on the initial diagnostic workup of cancer of unknown primary14
Evolving treatment for advanced non-small cell lung cancer harbouring common EGFR activating mutations14
Epigenetics in advanced renal cell carcinoma: Potential new targets14
Application of molecular imaging in immune checkpoints therapy: From response assessment to prognosis prediction14
Is antibody-drug conjugate a rising star for clinical treatment of solid tumors? A systematic review and meta-analysis14
Relationship between purinergic signalling and oxidative stress in prostate cancer: Perspectives for future therapy14
Unlocking the intricacies: Exploring the complex interplay between platelets and ovarian cancer14
Metaplastic breast cancer: A review14
Comment on “A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma”14
Adjuvant Mitotane in Low-Risk Adrenocortical Carcinoma: A Reconstructed IPD Analysis of the ADIUVO Randomized and Observational Studies13
Optimizing CDK4/6 inhibitors in advanced HR+/HER2- breast cancer: A personalized approach13
Warming-up the immune cell engagers (ICEs) era in breast cancer: state of the art and future directions13
Potential strategies to improve the therapeutic efficacy of oncolytic viruses for cancer through T and NK cells targeting13
Cancer-associated thrombosis in the era of precision oncology: Mechanisms, challenges and future directions13
Clinical implications of the Drug-Drug Interaction in Cancer Patients treated with innovative oncological treatments13
Differentiation therapy: Unlocking phenotypic plasticity of hepatocellular carcinoma13
Long non-coding RNA and the tumor microenvironment: Prospects for clinical applications in breast cancer13
Advancements in tumor-infiltrating lymphocytes: Historical insights, contemporary milestones, and future directions in oncology therapy13
Telomere maintenance meets cancer metabolism: Mechanistic insights and clinical opportunities13
Cellular senescence in tumor immune escape: Mechanisms, implications, and therapeutic potential13
How safe and effective is irradiating radiation-induced meningiomas? Single-center experience in primary and salvage Gamma-Knife Radiosurgery, systematic review, and metanalysis of current evidence on13
Optimizing management of cutaneous toxicities from amivantamab in first-line non-small cell lung cancer: A clinical perspective13
Surrogate endpoints in phase III randomized trials of advanced gastroesophageal cancer: A systematic review and meta-analysis13
The role of PIK3CA mutation in lobular breast cancer in the era of precision oncology – A systematic review13
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