Critical Reviews in Oncology Hematology

Article	Citations
Harnessing tumor metabolism during cancer treatment: A narrative review of emerging dietary approaches	211
Navigating management of localized prostate cancer in the geriatric population	155
Skin barrier dysfunction in cutaneous T-cell lymphoma: From pathogenic mechanism of barrier damage to treatment	124
A bone paradigm challenging the standard model of myeloma oncogenesis	121
Editorial Board	116
Instruments and scales for the evaluation of acute radiation dermatitis: A systematic review	91
Surface-Enhanced Raman Scattering (SERS) combined with machine learning enables accurate diagnosis of cervical cancer: From molecule to cell to tissue level	90
Direct and indirect effects on child neurocognitive development when maternal cancer is diagnosed during pregnancy: What do we know so far?	87
Open issues in the therapeutic management of unresectable stage III NSCLC in the immunotherapy era	70
Unveiling the Role of JAK2/STAT3 signaling in chemoresistance of gynecological cancers: From mechanisms to therapeutic implications	69
Novel bioengineered drugs with immunotherapies for malignant pleural effusion: Remodulate tumor immune microenvironment and activate immune system	68
Total neoadjuvant treatment and organ preservation strategies in the management of localized rectal cancer: A narrative review and evidence-based algorithm	67
The role of cGAS-STING in remodeling the tumor immune microenvironment induced by radiotherapy	65
Current status of locally advanced rectal cancer therapy and future prospects	64
Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study	63
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part II	58
Hurrying up but not rushing, acting and not reacting, good sense and not common sense: Open thoughts and reasonable doubts on COVID-19 vaccination strategies in cancer patients	57
Letter to the Editor regarding the article “A net-work meta-analysis of the cardiac safety for next-generation hormonal agents in treating castration-resistant prostate cancer: How to choose drugs app	57
Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics	55
Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis	55
A non-invasive miRNA-based approach in early diagnosis and therapeutics of oral cancer	52
Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: A systematic review and meta-analysis of randomized trials	51
Systemic immune-inflammation index as a predictor of survival in non-small cell lung cancer patients undergoing immune checkpoint inhibition: A systematic review and meta-analysis	47
Double agents in immunotherapy: Unmasking the role of antibody drug conjugates in immune checkpoint targeting	44
Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy	44

Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions	43
Efficacy of PD-1/PD-L1 immunotherapy on brain metastatic non-small-cell lung cancer and treatment-related adverse events: A systematic review	42
Development of treatment strategies for advanced HER2-positive gastric cancer: Insights from clinical trials	41
Microbiome and lung cancer: carcinogenic mechanisms, early cancer diagnosis, and promising microbial therapies	41
The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth	41
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models	40
Immuno-oncology therapy in metastatic bladder cancer: A systematic review and network meta-analysis	39
Immunotherapy in OSCC: Current trend and challenges	39
TIGIT: Will it be the next star therapeutic target like PD-1 in hematological malignancies?	37
ESO's career development program (2002-2021): Presentation and evaluation	37
Editorial Board	37
Pressurised intraperitoneal aerosolised chemotherapy (PIPAC) for gastric cancer with peritoneal metastases: A systematic review by the PIPAC UK collaborative	37
Optimal treatment strategy for central nervous system non-germinomatous germ cell tumors: A systematic review and meta-analysis	36
Editorial Board	36
Comment on “The risk of breast cancer and gynecologic malignancies after ovarian stimulation: Meta-analysis of cohort study”	34
Thrombosis and cachexia in cancer: Two partners in crime?	34
Can inflammasomes promote the pathophysiology of glioblastoma multiforme? A view about the potential of the anti-inflammasome therapy as pharmacological target	34
Targeting hypoxia-inducible factor pathways in sporadic and Von Hippel-Lindau syndrome-related kidney cancers	33
The biology and treatment of leiomyosarcomas	32
Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy	32
UGT1A1 Testing in Breast Cancer: should it become routine practice in patients treated with antibody-drug conjugates?	32
Management of secondary immunodeficiency in hematological malignancies in the era of modern oncology	32
First-line treatments for advanced or recurrent endometrial cancer: Systematic literature review of clinical evidence	31
Effect of exercise on functional capacity in patients with advanced cancer: A meta-analysis of randomized controlled trials	31
Advantages and drawbacks of dexamethasone in glioblastoma multiforme	31
Impact of immune cells on the hallmarks of cancer: A literature review	31
Cellular and molecular mechanisms implicated in the dual role of ROR2 in cancer	30
Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules	30
Neoadjuvant therapy for muscle-invasive bladder cancer: Current clinical scenario, future perspectives, and unsolved questions	30
Predictive factors for return to work among cancer survivors in Europe: A systematic review	29
Chemotherapy, immunotherapy, and targeted therapy for osteosarcoma: Recent advancements	29
KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics	29
Efficacy and safety of targeted therapy and immunotherapy in advanced vulvar squamous cell carcinoma: A scoping review	28
Quantifying absolute benefit for adjuvant treatment options in renal cell carcinoma: A living interactive systematic review and network meta-analysis	28
Clinical trials for patients with salivary gland cancers: A systematic review of worldwide registers and an evaluation of current challenges	27
A systematic review of systematic reviews and pooled meta-analysis on pharmacological interventions to improve cancer-related fatigue	27
A comprehensive review on targeting diverse immune cells for anticancer therapy: Beyond immune checkpoint inhibitors	27
Unraveling molecular mechanisms of head and neck cancer	27
The role and clinical significance of tumor-draining lymph nodes in tumor progression and immunotherapy	26
Unlocking the potential of Molecular Tumor Boards: from cutting-edge data interpretation to innovative clinical pathways	26
Efficacy of stereotactic radiosurgery as single or combined therapy for brain metastasis: A systematic review and meta-analysis	26
Synergistic effects of immunotherapy and adjunctive therapies in prostate cancer management	26
The role of central nervous system (CNS) prophylaxis in preventing DLBCL patients from CNS relapse: A network meta-analysis	26
Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors	25
The extracellular matrix in colorectal cancer and its metastatic settling – Alterations and biological implications	25
Unveilling the potential of liquid biopsy in pancreatic cancer for molecular diagnosis and treatment guidance	25
DLL3 as a potential diagnostic and therapeutic target in neuroendocrine neoplasms: A narrative review	25
The role of liquid biopsy in epithelial ovarian cancer: State of the art	25
CAR T-cell therapy landscape in pediatric, adolescent and young adult oncology – A comprehensive analysis of clinical trials	25
Comprehensive review of signaling pathways and therapeutic targets in gastrointestinal cancers	24

Bone health in glucocorticoid-treated childhood acute lymphoblastic leukemia	24
The Peripheral Tumor Neuro-Microenvironment: Deciphering Neural Landscape and Mechanistic Insights for Therapeutic Innovation	24
Editorial Board	24
Minimal residual disease testing for classical Hodgkin lymphoma: A comprehensive review	24
Decoding the puzzle: A multidisciplinary systematic review of adult brainstem glioma	23
Revolutionizing immunotherapy: The next frontier in CAR T-cell engineering	23
Recent development in bispecific antibody immunotherapy for hematological malignancies	23
Cardio-oncology concerns in radiotherapy: Heart and cardiac substructure toxicities from modern delivery techniques	23
Novel Methods of Risk Stratifying Patients for Metachronous, Pre-Malignant Colorectal Polyps: A Systematic Review	23
Prognostic and therapeutic value of somatic mutations in diffuse large B-cell lymphoma: A systematic review	23
Drug-based therapy for advanced adenoid cystic carcinoma: Current landscape and challenges based on an overview of registered clinical trials	23
« Augmented radiotherapy » in the management of high-risk prostate cancer (PCa): A systematic review	23
Epigenetic-modifying agents: The potential game changers in the treatment of hematologic malignancies	23
Sialylated glycoproteins and sialyltransferases in digestive cancers: Mechanisms, diagnostic biomarkers, and therapeutic targets	22
Recent advances and research progress in biomarkers for chronic graft versus host disease	22
Long-term strategies for management of advanced basal cell carcinoma with hedgehog inhibitors	22
Targeting TIME in advanced hepatocellular carcinoma: Mechanisms of drug resistance and treatment strategies	22
The association between paraneoplastic neurological syndromes (PNS) and urothelial carcinoma – A review of the literature	22
Personalized medicine for metastatic prostate cancer: The paradigm of PARP inhibitors	22
Receptor status of breast cancer diagnosed during pregnancy: A literature review	22
Facing the climate change: Is radiotherapy as green as we would like? A systematic review	22
Systematic review of tumour budding and association with common mutations in patients with colorectal cancer	21
Rethinking treatment paradigms: Neoadjuvant therapy and de-escalation strategies in HPV-positive head and neck cancer	21
C-reactive protein as a diagnostic and prognostic factor of endometrial cancer	21
Salvage radiotherapy after initial cryotherapy for localized prostate cancer: A systematic review of the literature	21
Strategies to overcome chemoresistance in epithelial ovarian cancer: Navigating beyond challenges	21
Combining gut microbiota modulation and immunotherapy: A promising approach for treating microsatellite stable colorectal cancer	21
Neurotoxicities of novel non-steroidal anti-androgens for prostate cancer: A systematic review and meta-analysis	21
Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities	21
Artificial intelligence: A promising frontier in bladder cancer diagnosis and outcome prediction	21
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer	20
Evaluation of clinical decision support systems in oncology: An updated systematic review	20
The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis	20
Role of radiation in chimeric antigen receptor T-cell therapy for patients with relapsed/refractory non-Hodgkin lymphoma: Current studies and future prospects	20
IHC-based molecular classification in muscle-invasive urothelial bladder carcinoma: prognostic and predictive value toward a clinically applicable IHC marker panel – A systematic review	20
Testicular germ cell tumors: Genomic alternations and RAS-dependent signaling	20
Safety and efficacy of liposomal irinotecan as the second-line treatment for advanced pancreatic cancer: A systematic review and meta-analysis	20
The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis	19
Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities	19
Immune checkpoint inhibitors as a threat to reproductive function: A systematic review	19
Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to lymphoma	19
Endometrial cancer in the elderly: Characteristics, prognostic and risk factors, and treatment options	19
Radiotherapy of high-grade gliomas: dealing with a stalemate	19
A scoping review to map the evidence of physical activity interventions in post-treatment adolescent and young adult cancer survivors	19
Navigating chemotherapy and immunotherapy in early-stage lung cancer. A critical review and statements from INTERACTION group	19
Progress in research: Daratumumab improves treatment outcomes of patients with AL amyloidosis	19
Can the tumor-agnostic evaluation of MSI/MMR status be the common denominator for the immunotherapy treatment of patients with several solid tumors?	18
Current landscape of hypoxia in thyroid cancer pathogenesis and treatment	18
Molecular oncology of iodine refractory thyroid cancer current therapies and perspective	18
Incidence of antibody–drug conjugates-related pneumonitis in patients with solid tumors: A systematic review and meta-analysis	18
The impact of survivorship bias in glioblastoma research	18
Role of innate immunity in tumor microenvironment of HPV-associated anal cancer: The hypothetical beneficial role of γδ T cells.	18
The diagnostic accuracy of single-item scales in detecting fatigue in patients with cancer: A systematic review and meta-analysis	17
Association between bevacizumab with cancer drug therapies and drug-induced interstitial lung disease in patients with solid tumor: A systematic review and meta-analysis of randomized clinical trials	17
Androgen annihilation versus advanced androgen blockage as first line treatment for metastatic castration resistant prostate cancer: A systematic review and meta-analysis	17
Deciphering the possible reciprocal loop between hepatic stellate cells and cancer cells in the tumor microenvironment of the liver	17
Combine radiotherapy and immunotherapy in esophageal squamous cell carcinoma	17
Molecular mechanisms of ferroptosis and its role in prostate cancer therapy	17
N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential	17
Targeting breast cancer stem cells through retinoids: A new hope for treatment	17
Uncovering the bookshelves of CRISPR-based libraries: Advances and applications in cancer studies	17
Symptomatologic outcomes of gut microbiota modifiers (probiotics, prebiotics and synbiotics) in cancer care: A scoping review of randomized controlled trials	17
Delta-like ligand 3 in small cell lung cancer: Potential mechanism and treatment progress	17
Rare histotypes of epithelial biliary tract tumors: A literature review	17
Stereotactic body radiotherapy boost as an alternative to brachytherapy for cervical cancer: A scoping review	16
Effect of non-pharmacological interventions on symptoms and quality of life in patients with hematological malignancies – A systematic review	16
Outcome after treatment with axitinib in children, young adults, and adults with renal cell carcinoma: a narrative review	16
The current landscape of systemic therapy for recurrent glioblastoma: A systematic review of randomized-controlled trials	16
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part I	16
A neuroendocrine biomarker revolution from monoanalyte to multianalyte biomarkers in non-functioning gastro-entero-pancreatic neuroendocrine neoplasms	16
The impact of PARP inhibitors in the whole scenario of ovarian cancer management: A systematic review and network meta-analysis	16
Editorial Board	16
Management of patients with extensive small-cell lung cancer in the immunotherapy era: An Italian consensus through a Delphi approach	16
The educational contribution of the college of the European school of oncology (ESCO): A survey analysis of the first three years	16
COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications	16
Neoadjuvant endocrine therapy for luminal breast tumors: State of the art, challenges and future perspectives	16
The application of stepped-wedge cluster-randomized controlled trial study designs in oncology settings: A systematic review	16
Editorial Board	16
WEE1 inhibition in cancer therapy: Mechanisms, synergies, preclinical insights, and clinical trials	16
The effect of COVID-19 pandemic on daily oncology clinical practice	16

Expanding horizons in cancer therapy by immunoconjugates targeting tumor microenvironments	16
Exploring the molecular interactions between ferroptosis and the Wnt/β-catenin signaling pathway: Implications for cancer and disease therapy	16
Status of breast cancer in Latin American: Results of the breast cancer revealed initiative	15
Which is the best treatment for melanoma brain metastases? A Bayesian network meta-analysis and systematic review	15
Evolving treatment for advanced non-small cell lung cancer harbouring common EGFR activating mutations	15
The roles of immune cells and non-immune cells in pre-metastatic niche of breast cancer	15
Epidermal growth factor receptor exon 20 insertion variants in non-small cell lung cancer patients	15
Spatial transcriptomics in pancreatic cancer: Advances, prospects and challenges	15
Significance of HOXD transcription factors family in progression, migration and angiogenesis of cancer	15
Gamma Knife radiosurgery as primary treatment of low-grade brainstem gliomas: A systematic review and metanalysis of current evidence and predictive factors	15
Radioprotective agents against the ionizing radiation-induced hematopoietic stem and progenitor cell injury; Foundation review	14
Metaplastic breast cancer: A review	14
KRAS G12C-mutant driven non-small cell lung cancer (NSCLC)	14
Somatic and germline ATM variants in non-small-cell lung cancer: Therapeutic implications	14
Protective effects of physical activity in colon cancer and underlying mechanisms: A review of epidemiological and biological evidence	14
The impact of gender on The efficacy of immune checkpoint inhibitors in cancer patients: The MOUSEION-01 study	14
The study of primary and acquired resistance to first-line osimertinib to improve the outcome of EGFR-mutated advanced Non-small cell lung cancer patients: the challenge is open for new therapeutic st	14
Profile of treatment-related adverse events of PD-1 blockade-based therapies in advanced esophageal cancer: A systematic review and meta-analysis	14
Standardized molecular pathology workflow for ctDNA-based ESR1 testing in HR+/HER2- metastatic breast cancer	14
Chimeric antigen receptor T cell immunotherapy for gynecological malignancies	14
Venous thromboembolism in cancer and cancer immunotherapy	14
Evidence-based recommendations for induction and maintenance treatment of newly diagnosed transplant-ineligible multiple myeloma patients	14
CD200 expression in hematopoietic neoplasms: Beyond a marker for diagnosis of B-cell neoplasms	14
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies	14
Targeting the DNA damage response: PARP inhibitors and new perspectives in the landscape of cancer treatment	14
International consensus on the initial diagnostic workup of cancer of unknown primary	13
Epigenetics in advanced renal cell carcinoma: Potential new targets	13
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib	13
HER2-targeted therapies: Unraveling their role in biliary tract cancers	13
Advancing patient setup: A comprehensive scoping review of tattoo-less techniques in radiation therapy	13
Is antibody-drug conjugate a rising star for clinical treatment of solid tumors? A systematic review and meta-analysis	13
Comment on “A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma”	13
Patients’ selection and trial matching in early-phase oncology clinical trials	13
Real-world insights into the efficacy and safety of tyrosine kinase inhibitors against thyroid cancers	13
Unlocking the intricacies: Exploring the complex interplay between platelets and ovarian cancer	13
DNA methylation in oral squamous cell carcinoma: from its role in carcinogenesis to potential inhibitor drugs	13
Editorial Board	13
The application of cancer stem cell model in malignant mesothelioma	13
Factors for a broad technology assessment of comprehensive genomic profiling in advanced cancer, a systematic review	13
Relationship between purinergic signalling and oxidative stress in prostate cancer: Perspectives for future therapy	13
Clonal hematopoiesis and inflammation: A review of mechanisms and clinical implications	13
Application of molecular imaging in immune checkpoints therapy: From response assessment to prognosis prediction	13
Advancements in tumor-infiltrating lymphocytes: Historical insights, contemporary milestones, and future directions in oncology therapy	12
Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments	12
Cellular senescence in tumor immune escape: Mechanisms, implications, and therapeutic potential	12
Perioperative imaging predictors of tumor progression and pseudoprogression: A systematic review	12
How safe and effective is irradiating radiation-induced meningiomas? Single-center experience in primary and salvage Gamma-Knife Radiosurgery, systematic review, and metanalysis of current evidence on	12
KRAS mutations in advanced non-small cell lung cancer: From biology to novel therapeutic strategies	12
Long non-coding RNA and the tumor microenvironment: Prospects for clinical applications in breast cancer	12
Transarterial radioembolization in neuroendocrine liver metastases 25 years later: A systematic review	12
Differentiation therapy: Unlocking phenotypic plasticity of hepatocellular carcinoma	12
Clinical implications of the Drug-Drug Interaction in Cancer Patients treated with innovative oncological treatments	12
Safety of immune checkpoint inhibitors: An updated comprehensive disproportionality analysis and meta-analysis	12
Bladder-sparing treatment for muscle-invasive bladder carcinoma using immune checkpoint inhibitors	12
Insights into Sorafenib resistance in hepatocellular carcinoma: Mechanisms and therapeutic aspects	12
Warming-up the immune cell engagers (ICEs) era in breast cancer: state of the art and future directions	12
Editorial Board	12
Diagnosis and treatment of therapy-related acute myeloid leukemia	12
Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms	12
Prediction performance of twelve tumor mutation burden panels in melanoma and non-small cell lung cancer	12
Which treatment after first line therapy in NSCLC patients without genetic alterations in the era of immunotherapy?	12
The potential of circulating cell-free RNA in CNS tumor diagnosis and monitoring: A liquid biopsy approach	12
Optimizing CDK4/6 inhibitors in advanced HR+/HER2- breast cancer: A personalized approach	12
HER2-low breast cancer: Novel detections and treatment advances	12
Surrogate endpoints in phase III randomized trials of advanced gastroesophageal cancer: A systematic review and meta-analysis	12
The prevalence of solid tumors and hematologic malignancies among patients with Down syndrome: A systematic review and meta-analysis	12
Key considerations for a prostate cancer mRNA vaccine	12
Head and neck squamous cell carcinoma: Exploring frontiers of combinatorial approaches with tyrosine kinase inhibitors and immune checkpoint therapy	12
Advanced and recurrent endometrial cancer: State of the art and future perspectives	12
Efficacy and safety of adjuvant chemotherapy for locally advanced cervical cancer: A systematic review and meta-analysis	11
Cost-effectiveness of first-line immunotherapy for advanced non-small cell lung cancer with different PD-L1 expression levels: A comprehensive overview	11
Obesity and prostate cancer: A narrative review	11
The integration of radiotherapy with systemic therapy in advanced triple-negative breast cancer	11
RNA-binding proteins in breast cancer: Biological implications and therapeutic opportunities	11
Prognostic and therapeutic potential of STAT3: Opportunities and challenges in targeting HPV-mediated cervical carcinogenesis	11
Molecular features and clinical actionability of gene fusions in colorectal cancer	11
Effectiveness of different treatment strategies in elderly patients with glioblastoma: An evidence map of randomized controlled trials	11
Management of early-stage ovarian cancer: Open questions and debated issues	11
Emerge of colorectal cancer in Lynch syndrome despite colonoscopy surveillance: A challenge of hide and seek	11
Alternative polyadenylation in cancer: Molecular mechanisms and clinical application	11
Supportive interventions for childhood cancer: An umbrella review of randomized evidence	11
Organisation of cancer care in troubling times: A scoping review of expert guidelines and their implementation during the COVID-19 pandemic	11
The effect of nutritional interventions in acute radiation-induced diarrhoea in patients with primary pelvic cancer: A systematic review	11
Small cell lung cancer unveiled: Exploring the untapped resource of circulating tumor cells-derived organoids	11
Corrigendum to “The emerging HER2 landscape in Colorectal Cancer: The key to unveil the future treatment algorithm?” [Crit. Rev. Oncol./Hematol. 204 (2024) 104515]	11
Central nervous system (CNS) prophylaxis in antiCD20-CHOP treated DLBCL at intermediate to high risk for CNS relapse: A systematic review and meta-analysis	11
The hematopoietic microenvironment of the fetal liver and transient abnormal myelopoiesis associated with Down syndrome: A review	11
Current knowledge of immunosuppression as a risk factor for skin cancer development	11
Clinical applications of radiomics and deep learning in breast and lung cancer: A narrative literature review on current evidence and future perspectives	11
Practical treatment guidance for cancer-associated thrombosis – Managing the challenging patient: A consensus statement	11
The impact of urine biomarkers for prostate cancer detection–A systematic state of the art review	11
Immune therapies of B-cell acute lymphoblastic leukaemia in children and adults	11
Clinical and molecular overview of immunotherapeutic approaches for malignant skin melanoma: Past, present and future	11
Addition of immunotherapy to chemotherapy for metastatic triple-negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	11
A systematic review of contemporary phase I trials in patients with lymphoma	11