Critical Reviews in Oncology Hematology

Article	Citations
Harnessing tumor metabolism during cancer treatment: A narrative review of emerging dietary approaches	180
Navigating management of localized prostate cancer in the geriatric population	168
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part II	143
Efficacy of PD-1/PD-L1 immunotherapy on brain metastatic non-small-cell lung cancer and treatment-related adverse events: A systematic review	121
Skin barrier dysfunction in cutaneous T-cell lymphoma: From pathogenic mechanism of barrier damage to treatment	117
A bone paradigm challenging the standard model of myeloma oncogenesis	105
Editorial Board	87
Total neoadjuvant treatment and organ preservation strategies in the management of localized rectal cancer: A narrative review and evidence-based algorithm	83
The role of cGAS-STING in remodeling the tumor immune microenvironment induced by radiotherapy	79
Double agents in immunotherapy: Unmasking the role of antibody drug conjugates in immune checkpoint targeting	70
The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth	66
Hurrying up but not rushing, acting and not reacting, good sense and not common sense: Open thoughts and reasonable doubts on COVID-19 vaccination strategies in cancer patients	63
Thrombotic microangiopathy (aHUS/iTTP) reported so far in Covid-19 patients: The virus alone or an omnium gatherum of mechanisms and etiologies?	60
Letter to the Editor regarding the article “A net-work meta-analysis of the cardiac safety for next-generation hormonal agents in treating castration-resistant prostate cancer: How to choose drugs app	60
Direct and indirect effects on child neurocognitive development when maternal cancer is diagnosed during pregnancy: What do we know so far?	59
Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics	59
Current status of locally advanced rectal cancer therapy and future prospects	56
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models	54
Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis	53
Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions	52
Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study	50
Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: A systematic review and meta-analysis of randomized trials	50
Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy	50
A non-invasive miRNA-based approach in early diagnosis and therapeutics of oral cancer	50
Instruments and scales for the evaluation of acute radiation dermatitis: A systematic review	46

Microbiome and lung cancer: carcinogenic mechanisms, early cancer diagnosis, and promising microbial therapies	45
Systemic immune-inflammation index as a predictor of survival in non-small cell lung cancer patients undergoing immune checkpoint inhibition: A systematic review and meta-analysis	42
Development of treatment strategies for advanced HER2-positive gastric cancer: Insights from clinical trials	41
Chemotherapy, immunotherapy, and targeted therapy for osteosarcoma: Recent advancements	40
Open issues in the therapeutic management of unresectable stage III NSCLC in the immunotherapy era	40
Meta-analysis of immune-related adverse events in phase 3 clinical trials assessing immune checkpoint inhibitors for lung cancer	38
Immuno-oncology therapy in metastatic bladder cancer: A systematic review and network meta-analysis	38
Neoadjuvant therapy for muscle-invasive bladder cancer: Current clinical scenario, future perspectives, and unsolved questions	38
ESO's career development program (2002-2021): Presentation and evaluation	38
Immunotherapy in OSCC: Current trend and challenges	38
Effect of exercise on functional capacity in patients with advanced cancer: A meta-analysis of randomized controlled trials	38
Editorial Board	37
Comment on “The risk of breast cancer and gynecologic malignancies after ovarian stimulation: Meta-analysis of cohort study”	36
Optimal treatment strategy for central nervous system non-germinomatous germ cell tumors: A systematic review and meta-analysis	36
Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules	35
Can inflammasomes promote the pathophysiology of glioblastoma multiforme? A view about the potential of the anti-inflammasome therapy as pharmacological target	35
TIGIT: Will it be the next star therapeutic target like PD-1 in hematological malignancies?	35
First-line treatments for advanced or recurrent endometrial cancer: Systematic literature review of clinical evidence	35
Management of secondary immunodeficiency in hematological malignancies in the era of modern oncology	34
KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics	34
Targeting hypoxia-inducible factor pathways in sporadic and Von Hippel-Lindau syndrome-related kidney cancers	33
Advantages and drawbacks of dexamethasone in glioblastoma multiforme	33
Cellular and molecular mechanisms implicated in the dual role of ROR2 in cancer	32
Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy	32
Thrombosis and cachexia in cancer: Two partners in crime?	31
UGT1A1 Testing in Breast Cancer: should it become routine practice in patients treated with antibody-drug conjugates?	31
Pressurised intraperitoneal aerosolised chemotherapy (PIPAC) for gastric cancer with peritoneal metastases: A systematic review by the PIPAC UK collaborative	30
Quantifying absolute benefit for adjuvant treatment options in renal cell carcinoma: A living interactive systematic review and network meta-analysis	30
Predictive factors for return to work among cancer survivors in Europe: A systematic review	30
Bone health in glucocorticoid-treated childhood acute lymphoblastic leukemia	30
Impact of immune cells on the hallmarks of cancer: A literature review	30
The biology and treatment of leiomyosarcomas	30
DLL3 as a potential diagnostic and therapeutic target in neuroendocrine neoplasms: A narrative review	30
A systematic review of systematic reviews and pooled meta-analysis on pharmacological interventions to improve cancer-related fatigue	29
Efficacy and safety of targeted therapy and immunotherapy in advanced vulvar squamous cell carcinoma: A scoping review	28
Efficacy of stereotactic radiosurgery as single or combined therapy for brain metastasis: A systematic review and meta-analysis	28
The role of central nervous system (CNS) prophylaxis in preventing DLBCL patients from CNS relapse: A network meta-analysis	28
Unlocking the potential of Molecular Tumor Boards: from cutting-edge data interpretation to innovative clinical pathways	27
A comprehensive review on targeting diverse immune cells for anticancer therapy: Beyond immune checkpoint inhibitors	27
Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors	27
The role of liquid biopsy in epithelial ovarian cancer: State of the art	27
Synergistic effects of immunotherapy and adjunctive therapies in prostate cancer management	27
The extracellular matrix in colorectal cancer and its metastatic settling – Alterations and biological implications	26
Sialylated glycoproteins and sialyltransferases in digestive cancers: Mechanisms, diagnostic biomarkers, and therapeutic targets	26
CAR T-cell therapy landscape in pediatric, adolescent and young adult oncology – A comprehensive analysis of clinical trials	26
Unraveling molecular mechanisms of head and neck cancer	26
Minimal residual disease testing for classical Hodgkin lymphoma: A comprehensive review	26
Novel Methods of Risk Stratifying Patients for Metachronous, Pre-Malignant Colorectal Polyps: A Systematic Review	25
Role of radiation in chimeric antigen receptor T-cell therapy for patients with relapsed/refractory non-Hodgkin lymphoma: Current studies and future prospects	25
Editorial Board	25

Comprehensive review of signaling pathways and therapeutic targets in gastrointestinal cancers	25
Drug-based therapy for advanced adenoid cystic carcinoma: Current landscape and challenges based on an overview of registered clinical trials	24
« Augmented radiotherapy » in the management of high-risk prostate cancer (PCa): A systematic review	24
The association between paraneoplastic neurological syndromes (PNS) and urothelial carcinoma – A review of the literature	24
Epigenetic modulation of the tumor microenvironment in head and neck cancer: Challenges and opportunities	24
Prognostic and therapeutic value of somatic mutations in diffuse large B-cell lymphoma: A systematic review	24
Epigenetic-modifying agents: The potential game changers in the treatment of hematologic malignancies	24
Surgical treatment of gastric cancer liver metastases: Systematic review and meta-analysis of long-term outcomes and prognostic factors	24
Rethinking treatment paradigms: Neoadjuvant therapy and de-escalation strategies in HPV-positive head and neck cancer	24
C-reactive protein as a diagnostic and prognostic factor of endometrial cancer	24
Systematic review of tumour budding and association with common mutations in patients with colorectal cancer	24
Cardio-oncology concerns in radiotherapy: Heart and cardiac substructure toxicities from modern delivery techniques	23
Salvage radiotherapy after initial cryotherapy for localized prostate cancer: A systematic review of the literature	23
Artificial intelligence: A promising frontier in bladder cancer diagnosis and outcome prediction	23
Combining gut microbiota modulation and immunotherapy: A promising approach for treating microsatellite stable colorectal cancer	23
Recent advances and research progress in biomarkers for chronic graft versus host disease	23
Safety and efficacy of liposomal irinotecan as the second-line treatment for advanced pancreatic cancer: A systematic review and meta-analysis	23
Long-term strategies for management of advanced basal cell carcinoma with hedgehog inhibitors	23
Decoding the puzzle: A multidisciplinary systematic review of adult brainstem glioma	22
Facing the climate change: Is radiotherapy as green as we would like? A systematic review	22
Receptor status of breast cancer diagnosed during pregnancy: A literature review	22
Personalized medicine for metastatic prostate cancer: The paradigm of PARP inhibitors	22
Neurotoxicities of novel non-steroidal anti-androgens for prostate cancer: A systematic review and meta-analysis	22
The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review	22
Strategies to overcome chemoresistance in epithelial ovarian cancer: Navigating beyond challenges	22
Immune checkpoint inhibitors as a threat to reproductive function: A systematic review	21
Editorial Board	21
Navigating chemotherapy and immunotherapy in early-stage lung cancer. A critical review and statements from INTERACTION group	21
Androgen annihilation versus advanced androgen blockage as first line treatment for metastatic castration resistant prostate cancer: A systematic review and meta-analysis	21
Radiotherapy of high-grade gliomas: dealing with a stalemate	20
Can the tumor-agnostic evaluation of MSI/MMR status be the common denominator for the immunotherapy treatment of patients with several solid tumors?	20
Rare histotypes of epithelial biliary tract tumors: A literature review	20
The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis	20
Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities	20
Testicular germ cell tumors: Genomic alternations and RAS-dependent signaling	20
Combine radiotherapy and immunotherapy in esophageal squamous cell carcinoma	20
Molecular oncology of iodine refractory thyroid cancer current therapies and perspective	20
The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis	20
Progress in research: Daratumumab improves treatment outcomes of patients with AL amyloidosis	20
The impact of survivorship bias in glioblastoma research	20
Endometrial cancer in the elderly: Characteristics, prognostic and risk factors, and treatment options	20
Deciphering the possible reciprocal loop between hepatic stellate cells and cancer cells in the tumor microenvironment of the liver	19
A scoping review to map the evidence of physical activity interventions in post-treatment adolescent and young adult cancer survivors	19
Uncovering the bookshelves of CRISPR-based libraries: Advances and applications in cancer studies	19
The diagnostic accuracy of single-item scales in detecting fatigue in patients with cancer: A systematic review and meta-analysis	19
Radiosensitization Strategies for Hepatocellular Carcinoma: Mechanisms, Therapeutic Advances, and Clinical Perspectives	19
Incidence of antibody–drug conjugates-related pneumonitis in patients with solid tumors: A systematic review and meta-analysis	19
N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential	19
Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to lymphoma	19
Association between bevacizumab with cancer drug therapies and drug-induced interstitial lung disease in patients with solid tumor: A systematic review and meta-analysis of randomized clinical trials	19
Targeting breast cancer stem cells through retinoids: A new hope for treatment	19
Effectiveness of photobiomodulation therapy in radiation dermatitis: A systematic review and meta-analysis	19
Molecular mechanisms of ferroptosis and its role in prostate cancer therapy	19
The application of stepped-wedge cluster-randomized controlled trial study designs in oncology settings: A systematic review	18
Delta-like ligand 3 in small cell lung cancer: Potential mechanism and treatment progress	18
Editorial Board	18
Evaluation of clinical decision support systems in oncology: An updated systematic review	18
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer	18
Editorial Board	17
Status of breast cancer in Latin American: Results of the breast cancer revealed initiative	17
Exploring the molecular interactions between ferroptosis and the Wnt/β-catenin signaling pathway: Implications for cancer and disease therapy	17
Management of patients with extensive small-cell lung cancer in the immunotherapy era: An Italian consensus through a Delphi approach	17
The educational contribution of the college of the European school of oncology (ESCO): A survey analysis of the first three years	17
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part I	17
Outcome after treatment with axitinib in children, young adults, and adults with renal cell carcinoma: a narrative review	17
Dynamic crosstalk within the tumor microenvironment of uterine cervical carcinoma: baseline network, iatrogenic alterations, and translational implications	17
Profile of treatment-related adverse events of PD-1 blockade-based therapies in advanced esophageal cancer: A systematic review and meta-analysis	17
Effect of non-pharmacological interventions on symptoms and quality of life in patients with hematological malignancies – A systematic review	17
Stereotactic body radiotherapy boost as an alternative to brachytherapy for cervical cancer: A scoping review	17
Somatic and germline ATM variants in non-small-cell lung cancer: Therapeutic implications	17
Gamma Knife radiosurgery as primary treatment of low-grade brainstem gliomas: A systematic review and metanalysis of current evidence and predictive factors	16
The effect of COVID-19 pandemic on daily oncology clinical practice	16
Expanding horizons in cancer therapy by immunoconjugates targeting tumor microenvironments	16
Spatial transcriptomics in pancreatic cancer: Advances, prospects and challenges	16
A neuroendocrine biomarker revolution from monoanalyte to multianalyte biomarkers in non-functioning gastro-entero-pancreatic neuroendocrine neoplasms	16
Targeting the DNA damage response: PARP inhibitors and new perspectives in the landscape of cancer treatment	16
The current landscape of systemic therapy for recurrent glioblastoma: A systematic review of randomized-controlled trials	16
Chimeric antigen receptor T cell immunotherapy for gynecological malignancies	16
COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications	16
Epidermal growth factor receptor exon 20 insertion variants in non-small cell lung cancer patients	16

The impact of PARP inhibitors in the whole scenario of ovarian cancer management: A systematic review and network meta-analysis	16
Evidence-based recommendations for induction and maintenance treatment of newly diagnosed transplant-ineligible multiple myeloma patients	16
CD200 expression in hematopoietic neoplasms: Beyond a marker for diagnosis of B-cell neoplasms	16
Protective effects of physical activity in colon cancer and underlying mechanisms: A review of epidemiological and biological evidence	15
International consensus on the initial diagnostic workup of cancer of unknown primary	15
Neoadjuvant endocrine therapy for luminal breast tumors: State of the art, challenges and future perspectives	15
Standardized molecular pathology workflow for ctDNA-based ESR1 testing in HR+/HER2- metastatic breast cancer	15
Which is the best treatment for melanoma brain metastases? A Bayesian network meta-analysis and systematic review	15
Venous thromboembolism in cancer and cancer immunotherapy	15
Application of molecular imaging in immune checkpoints therapy: From response assessment to prognosis prediction	15
HER2-targeted therapies: Unraveling their role in biliary tract cancers	15
The study of primary and acquired resistance to first-line osimertinib to improve the outcome of EGFR-mutated advanced Non-small cell lung cancer patients: the challenge is open for new therapeutic st	15
KRAS G12C-mutant driven non-small cell lung cancer (NSCLC)	15
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies	15
Hematopoietic stem cell stretches and moves in its bone marrow niche	15
Editorial Board	15
Significance of HOXD transcription factors family in progression, migration and angiogenesis of cancer	15
The impact of gender on The efficacy of immune checkpoint inhibitors in cancer patients: The MOUSEION-01 study	15
Metaplastic breast cancer: A review	15
Epigenetics in advanced renal cell carcinoma: Potential new targets	14
Clonal hematopoiesis and inflammation: A review of mechanisms and clinical implications	14
Advancing patient setup: A comprehensive scoping review of tattoo-less techniques in radiation therapy	14
DNA methylation in oral squamous cell carcinoma: from its role in carcinogenesis to potential inhibitor drugs	14
KRAS mutations in advanced non-small cell lung cancer: From biology to novel therapeutic strategies	14
Comment on “A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma”	14
Patients’ selection and trial matching in early-phase oncology clinical trials	14
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib	14
Real-world insights into the efficacy and safety of tyrosine kinase inhibitors against thyroid cancers	14
Unlocking the intricacies: Exploring the complex interplay between platelets and ovarian cancer	14
Diagnosis and treatment of therapy-related acute myeloid leukemia	14
The application of cancer stem cell model in malignant mesothelioma	14
Factors for a broad technology assessment of comprehensive genomic profiling in advanced cancer, a systematic review	14
Is antibody-drug conjugate a rising star for clinical treatment of solid tumors? A systematic review and meta-analysis	14
Relationship between purinergic signalling and oxidative stress in prostate cancer: Perspectives for future therapy	14
The prevalence of solid tumors and hematologic malignancies among patients with Down syndrome: A systematic review and meta-analysis	14
Head and neck squamous cell carcinoma: Exploring frontiers of combinatorial approaches with tyrosine kinase inhibitors and immune checkpoint therapy	13
The diverse molecular profiles of lynch syndrome-associated colorectal cancers are (highly) dependent on underlying germline mismatch repair mutations	13
Bladder-sparing treatment for muscle-invasive bladder carcinoma using immune checkpoint inhibitors	13
The potential of circulating cell-free RNA in CNS tumor diagnosis and monitoring: A liquid biopsy approach	13
Editorial Board	13
Advancements in tumor-infiltrating lymphocytes: Historical insights, contemporary milestones, and future directions in oncology therapy	13
Managing side effects of immune checkpoint inhibitors in breast cancer	13
Perioperative imaging predictors of tumor progression and pseudoprogression: A systematic review	13
How safe and effective is irradiating radiation-induced meningiomas? Single-center experience in primary and salvage Gamma-Knife Radiosurgery, systematic review, and metanalysis of current evidence on	13
Live European School of Oncology e-Sessions (e-ESO)	13
Differentiation therapy: Unlocking phenotypic plasticity of hepatocellular carcinoma	13
Optimizing CDK4/6 inhibitors in advanced HR+/HER2- breast cancer: A personalized approach	13
Small cell lung cancer unveiled: Exploring the untapped resource of circulating tumor cells-derived organoids	13
Surrogate endpoints in phase III randomized trials of advanced gastroesophageal cancer: A systematic review and meta-analysis	13
Warming-up the immune cell engagers (ICEs) era in breast cancer: state of the art and future directions	13
Long non-coding RNA and the tumor microenvironment: Prospects for clinical applications in breast cancer	13
Cellular senescence in tumor immune escape: Mechanisms, implications, and therapeutic potential	12
HER2-low breast cancer: Novel detections and treatment advances	12
Which treatment after first line therapy in NSCLC patients without genetic alterations in the era of immunotherapy?	12
Key considerations for a prostate cancer mRNA vaccine	12
Molecular features and clinical actionability of gene fusions in colorectal cancer	12
Prognostic and therapeutic potential of STAT3: Opportunities and challenges in targeting HPV-mediated cervical carcinogenesis	12
A systematic review of contemporary phase I trials in patients with lymphoma	12
Prediction performance of twelve tumor mutation burden panels in melanoma and non-small cell lung cancer	12
Liquid biopsy and preclinical tools for advancing diagnosis and treatment of patients with pancreatic neuroendocrine neoplasms	12
Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments	12
Corrigendum to “The emerging HER2 landscape in Colorectal Cancer: The key to unveil the future treatment algorithm?” [Crit. Rev. Oncol./Hematol. 204 (2024) 104515]	12
Alternative polyadenylation in cancer: Molecular mechanisms and clinical application	12
The effect of nutritional interventions in acute radiation-induced diarrhoea in patients with primary pelvic cancer: A systematic review	12
Clinical implications of the Drug-Drug Interaction in Cancer Patients treated with innovative oncological treatments	12
Transarterial radioembolization in neuroendocrine liver metastases 25 years later: A systematic review	12
Advanced and recurrent endometrial cancer: State of the art and future perspectives	12
Safety of immune checkpoint inhibitors: An updated comprehensive disproportionality analysis and meta-analysis	12
Supportive interventions for childhood cancer: An umbrella review of randomized evidence	12
Cost-effectiveness of first-line immunotherapy for advanced non-small cell lung cancer with different PD-L1 expression levels: A comprehensive overview	12
Clinical and molecular overview of immunotherapeutic approaches for malignant skin melanoma: Past, present and future	12
The integration of radiotherapy with systemic therapy in advanced triple-negative breast cancer	11
Personalized medicine in oral cancer	11
Systemic treatment for hormone receptor-positive/HER2-negative advanced/metastatic breast cancer: A review of European real-world evidence studies	11
Spectrum and genotyping strategies of “dark” genetic matter in germline susceptibility genes of tumor syndromes	11
Current knowledge of immunosuppression as a risk factor for skin cancer development	11
The potential targeted drugs for fusion genes including NRG1 in pancreatic cancer	11
Obesity and prostate cancer: A narrative review	11
Pseudoprogression in lung cancer patients treated with immunotherapy	11
The hematopoietic microenvironment of the fetal liver and transient abnormal myelopoiesis associated with Down syndrome: A review	11
Editorial Board	11
Efficacy and safety of adjuvant chemotherapy for locally advanced cervical cancer: A systematic review and meta-analysis	11
Effectiveness of different treatment strategies in elderly patients with glioblastoma: An evidence map of randomized controlled trials	11
Central nervous system (CNS) prophylaxis in antiCD20-CHOP treated DLBCL at intermediate to high risk for CNS relapse: A systematic review and meta-analysis	11
Practical treatment guidance for cancer-associated thrombosis – Managing the challenging patient: A consensus statement	11
Organisation of cancer care in troubling times: A scoping review of expert guidelines and their implementation during the COVID-19 pandemic	11
Management of early-stage ovarian cancer: Open questions and debated issues	11
The impact of urine biomarkers for prostate cancer detection–A systematic state of the art review	11
Emerge of colorectal cancer in Lynch syndrome despite colonoscopy surveillance: A challenge of hide and seek	11
Immune therapies of B-cell acute lymphoblastic leukaemia in children and adults	11
Addition of immunotherapy to chemotherapy for metastatic triple-negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	11
Clinical applications of radiomics and deep learning in breast and lung cancer: A narrative literature review on current evidence and future perspectives	11
Physical activity for cancer prehabilitation: A scoping review	11
RNA-binding proteins in breast cancer: Biological implications and therapeutic opportunities	11