Critical Reviews in Oncology Hematology

Article	Citations
Molecular testing and targeted therapy for non-small cell lung cancer: Current status and perspectives	248
Cancer patients and research during COVID-19 pandemic: A systematic review of current evidence	149
ctDNA as a cancer biomarker: A broad overview	131
TMB or not TMB as a biomarker: That is the question	117
The impact of gender on The efficacy of immune checkpoint inhibitors in cancer patients: The MOUSEION-01 study	96
Beyond EGFR, ALK and ROS1: Current evidence and future perspectives on newly targetable oncogenic drivers in lung adenocarcinoma	86
Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles	85
Challenges and opportunities of cfDNA analysis implementation in clinical practice: Perspective of the International Society of Liquid Biopsy (ISLB)	75
Immune system in cancer radiotherapy: Resistance mechanisms and therapy perspectives	74
Ferroptosis: An emerging approach for targeting cancer stem cells and drug resistance	71
International liquid biopsy standardization alliance white paper	67
Unmet supportive care needs of people with advanced cancer and their caregivers: A systematic scoping review	62
Chronic inflammation towards cancer incidence: A systematic review and meta-analysis of epidemiological studies	61
Can mHealth interventions improve quality of life of cancer patients? A systematic review and meta-analysis	61
Breast cancer, screening and diagnostic tools: All you need to know	58
Immunotherapy addition to neoadjuvant chemotherapy for early triple negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	53
Liquid biopsy in bladder cancer: State of the art and future perspectives	53
Emerging role of exosomes as biomarkers in cancer treatment and diagnosis	52
CD47: the next checkpoint target for cancer immunotherapy	51
Immunotherapy for head and neck cancer: Present and future	50
New advances in exosome-based targeted drug delivery systems	50
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies	49
The main sources of circulating cell-free DNA: Apoptosis, necrosis and active secretion	48
Comprehensive review of chromophobe renal cell carcinoma	48
Volatile organic compounds in human matrices as lung cancer biomarkers: a systematic review	48

Mortality in adult patients with solid or hematological malignancies and SARS-CoV-2 infection with a specific focus on lung and breast cancers: A systematic review and meta-analysis	46
Autophagy-related MicroRNAs in chronic lung diseases and lung cancer	45
Major and minor salivary gland tumours	45
The role of epithelial-mesenchymal transition in regulating radioresistance	45
Reactive oxygen species (ROS): Critical roles in breast tumor microenvironment	43
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer	43
Immunotherapy improves efficacy and safety of patients with HPV positive and negative head and neck cancer: A systematic review and meta-analysis	42
A BRAF new world	41
Fathoming the link between anthropogenic chemical contamination and thyroid cancer	40
The tumor-agnostic treatment for patients with solid tumors: a position paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIF Italian Scientific Societies	40
Immune evasion mechanisms in acute myeloid leukemia: A focus on immune checkpoint pathways	40
PD-L1 expression and Tumor mutation burden as Pathological response biomarkers of Neoadjuvant immunotherapy for Early-stage Non-small cell lung cancer: A systematic review and meta-analysis	39
COVID 19 therapies and anti-cancer drugs: A systematic review of recent literature	39
Triple negative breast cancer in the era of miRNA	38
Melanoma of unknown primary: New perspectives for an old story	38
Extranodal NK/T cell lymphoma, nasal type: An updated overview	38
Targeting CDK4 (cyclin-dependent kinase) amplification in liposarcoma: A comprehensive review	38
Exercise for individuals with bone metastases: A systematic review	37
Platelet-mediated tumor metastasis mechanism and the role of cell adhesion molecules	37
Molecular landscape of recurrent cervical cancer	37
Interactions between androgen receptor signaling and other molecular pathways in prostate cancer progression: Current and future clinical implications	36
The clinical utility of microsatellite instability in colorectal cancer	36
Prevention and treatment of FGFR inhibitor-associated toxicities	36
Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study	36
Radiomics in cervical cancer: Current applications and future potential	36
Characteristics of gastric cancer around the world	35
Systemic Therapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma- A Systematic Review and Meta-Analysis	35
Efficacy and safety of PARP inhibitors in the treatment of advanced ovarian cancer: An updated systematic review and meta-analysis of randomized controlled trials	34
Psychosocial, behavioral, and supportive interventions for pediatric, adolescent, and young adult cancer survivors: A systematic review and meta-analysis	34
Global prevalence of human papillomavirus-driven oropharyngeal squamous cell carcinoma following the ASCO guidelines: A systematic review and meta-analysis	33
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models	33
Efficacy and safety of ibrutinib in diffuse large B-cell lymphoma: A single-arm meta-analysis	33
Pseudoprogression versus true progression in glioblastoma patients: A multiapproach literature review. Part 2 – Radiological features and metric markers	32
Role and toxicity of radiation therapy in neuroblastoma patients: A literature review	32
First-line systemic therapy for metastatic castration-sensitive prostate cancer: An updated systematic review with novel findings	32
PARP and PD-1/PD-L1 checkpoint inhibition in recurrent or metastatic endometrial cancer	31
Obesity and prostate cancer: A narrative review	31
Which type of cancer patients are more susceptible to the SARS-COX-2: Evidence from a meta-analysis and bioinformatics analysis	31
miR-26 family and its target genes in tumorigenesis and development	31
Health-related quality of life in curatively-treated patients with esophageal or gastric cancer: A systematic review and meta-analysis	31
Latest evidence on immune checkpoint inhibitors in metastatic colorectal cancer: A 2022 update	30
The significance of stromal collagen organization in cancer tissue: An in-depth discussion of literature	30
Exposure to endocrine disruptors and risk of breast cancer: A systematic review	30
Artificial intelligence: A promising frontier in bladder cancer diagnosis and outcome prediction	30
Introducing immunotherapy for advanced hepatocellular carcinoma patients: Too early or too fast?	30
Rational use of 18F-FDG PET/CT in patients with advanced cutaneous melanoma: A systematic review	29
Non-coding RNAs and macrophage interaction in tumor progression	29
Tumor hypoxia: The major culprit behind cisplatin resistance in cancer patients	29
C-reactive protein as a diagnostic and prognostic factor of endometrial cancer	29
Predictors of efficacy of androgen-receptor-axis-targeted therapies in patients with metastatic castration-sensitive prostate cancer: A systematic review and meta-analysis	28

The effect of exercise and motor interventions on physical activity and motor outcomes during and after medical intervention for children and adolescents with acute lymphoblastic leukemia: A systemati	28
Coronavirus infection and immune system: An insight of COVID-19 in cancer patients	28
Combination of HGF/MET-targeting agents and other therapeutic strategies in cancer	27
Preimplantation genetic testing for carriers of BRCA1/2 pathogenic variants	27
Radiomics and “radi-…omics” in cancer immunotherapy: a guide for clinicians	27
Ischemic stroke: A paradoxical manifestation of cancer	27
The prevalence of cancer associated systemic inflammation: Implications of prognostic studies using the Glasgow Prognostic Score	27
Toxicity profile of epidermal growth factor receptor tyrosine kinase inhibitors for patients with lung cancer: A systematic review and network meta-analysis	26
A meta-analysis of CD274 (PD-L1) assessment and prognosis in colorectal cancer and its role in predicting response to anti-PD-1 therapy	26
Impact of immune cells on the hallmarks of cancer: A literature review	26
Muscle hypertrophy in cancer patients and survivors via strength training. A meta-analysis and meta-regression	26
A user’s guide to lorlatinib	26
Osteosarcoma, chondrosarcoma and Ewing sarcoma: Clinical aspects, biomarker discovery and liquid biopsy	25
The challenge of the Molecular Tumor Board empowerment in clinical oncology practice: A Position Paper on behalf of the AIOM- SIAPEC/IAP-SIBioC-SIC-SIF-SIGU-SIRM Italian Scientific Societies	25
Low-risk triple-negative breast cancers: Clinico-pathological and molecular features	25
The role of chemotherapy in treatment of advanced breast cancer: an overview for clinical practice	25
The application of nano-medicine to overcome the challenges related to immune checkpoint blockades in cancer immunotherapy: Recent advances and opportunities	25
Risk of thrombosis with thrombopoietin receptor agonists for ITP patients: A systematic review and meta-analysis	24
Why brain radiation therapy should take account of the individual structural and functional connectivity: Toward an irradiation “à la carte”	24
Rechallenge of immune checkpoint inhibitors: A systematic review and meta-analysis	24
Effects of mindfulness-based interventions on fatigue in cancer survivors: A systematic review and meta-analysis of randomized controlled trials	24
The use of moderately hypofractionated post-operative radiation therapy for breast cancer in clinical practice: A critical review	24
Next generation sequencing for liquid biopsy based testing in non-small cell lung cancer in 2021	24
Meta-analysis of immune-related adverse events in phase 3 clinical trials assessing immune checkpoint inhibitors for lung cancer	24
Gene expression signatures: A tool for analysis of breast cancer prognosis and therapy	23
Chemotherapy for advanced gallbladder cancer (GBC): A systematic review and meta-analysis	23
Cardiotoxicity in breast cancer patients treated with radiation therapy: From evidences to controversies	23
COVID-19 and immunothrombosis: Pathophysiology and therapeutic implications	23
Cell signaling pathways as molecular targets to eliminate AML stem cells	23
Oral potentially malignant disorders: A scoping review of prognostic biomarkers	22
Neoadjuvant chemotherapy in hormone receptor-positive/HER2-negative early breast cancer: When, why and what?	22
A critical review on the dissemination of PH and stimuli-responsive polymeric nanoparticular systems to improve drug delivery in cancer therapy	22
Immune checkpoint inhibitors in endometrial cancer	22
Rehabilitation, exercise, and related non-pharmacological interventions for chemotherapy-induced peripheral neurotoxicity: Systematic review and evidence-based recommendations	21
Tumor infiltrating lymphocytes (TILs) as a predictive biomarker of response to checkpoint blockers in solid tumors: A systematic review	21
Development of asciminib, a novel allosteric inhibitor of BCR-ABL1	21
Cancer stem cells in colorectal cancer: Signaling pathways involved in stemness and therapy resistance	21
The impact of anthropometric parameters on colorectal cancer prognosis: A systematic review and meta-analysis	21
The complex interplay of gut microbiota with the five most common cancer types: From carcinogenesis to therapeutics to prognoses	21
Management of pain in colorectal cancer patients	20
The use of bolus in postmastectomy radiation therapy for breast cancer: A systematic review	20
Accuracy of the Multinational Association of Supportive Care in Cancer (MASCC) and Clinical Index of Stable Febrile Neutropenia (CISNE) scores for predicting serious complications in adult patients wi	20
The evolving landscape of anatomic pathology	20
Molecular mechanisms of ferroptosis and its role in prostate cancer therapy	20
Extracellular vesicles as biomarkers in malignant pleural mesothelioma: A review	20
Mantle cell lymphoma	20
Role of neutrophil-lymphocyte ratio as a predictive factor of glioma tumor grade: A systematic review	20
TERT promoter mutations and melanoma survival: A comprehensive literature review and meta-analysis	20
The association between antibiotics use and outcome of cancer patients treated with immune checkpoint inhibitors: A systematic review and meta-analysis	20
Diagnosis and treatment of therapy-related acute myeloid leukemia	20
Natural Killer cells and monoclonal antibodies: Two partners for successful antibody dependent cytotoxicity against tumor cells	19
Lymphopenia and intratumoral lymphocytic balance in the era of cancer immuno-radiotherapy	19
DNA methylation in oral squamous cell carcinoma: from its role in carcinogenesis to potential inhibitor drugs	19
Chimeric antigen receptor T cell therapy in oncology – Pipeline at a glance: Analysis of the ClinicalTrials.gov database	19
Bone marrow/bone pre-metastatic niche for breast cancer cells colonization: The role of mesenchymal stromal cells	19
Can the tumor-agnostic evaluation of MSI/MMR status be the common denominator for the immunotherapy treatment of patients with several solid tumors?	19
Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy	19
Exercise and lung cancer surgery: A systematic review of randomized-controlled trials	19
Recent insights into the role of the microbiome in malignant and benign hematologic diseases	18
Does nutrition for cancer patients feed the tumour? A clinical perspective	18
PI3K inhibition in breast cancer: Identifying and overcoming different flavors of resistance	18
A systematic review and meta-analysis of the association between circulating tumor DNA (ctDNA) and prognosis in pancreatic cancer	18
Stereotactic reirradiation for local failure of brain metastases following previous radiosurgery: Systematic review and meta-analysis	18
Prognostic value of platelet-related measures for overall survival in esophageal squamous cell carcinoma: A systematic review and meta-analysis	18
Cetuximab in locally advanced head and neck squamous cell carcinoma: Biological mechanisms involved in efficacy, toxicity and resistance	18
Lymphoma in the setting of autoimmune diseases: A review of association and mechanisms	18
Systematic review: Soluble immunological biomarkers in advanced non-small-cell lung cancer (NSCLC)	18
Nanomedicine tactics in cancer treatment: Challenge and hope	18
Breast cancer: An insight into its inflammatory, molecular, pathological and targeted facets with update on investigational drugs	18
Metabolic rewiring in melanoma drug-resistant cells	18
The relationship between hypoxia-inducible factor 1α (HIF-1α) and patient survival in breast cancer: Systematic review and meta-analysis	18
The storm of NGS in NSCLC diagnostic-therapeutic pathway: How to sun the real clinical practice	18
Exploring the role of respiratory microbiome in lung cancer: A systematic review	18
The Impact of Pelvic Nodal Radiotherapy on Hematologic Toxicity: A Systematic Review with Focus on Leukopenia, Lymphopenia and Future Perspectives in Prostate Cancer Treatment	18
Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments	18
Advantages and drawbacks of dexamethasone in glioblastoma multiforme	18
Update on drug transporter proteins in acute myeloid leukemia: Pathological implication and clinical setting	18
Circulating tumour DNA and melanoma survival: A systematic literature review and meta-analysis	17
Pseudoprogression versus true progression in glioblastoma patients: A multiapproach literature review	17
PD-1/PD-L1 inhibitor monotherapy or in combination with chemotherapy as upfront treatment for advanced NSCLC with PD-L1 expression ≥ 50%: Selecting the best strategy	17

Novel aspects on gonadotoxicity and fertility preservation in lymphoproliferative neoplasms	17
Management guidelines for stage III non-small cell lung cancer	17
Evolving pancreatic cancer treatment: From diagnosis to healthcare management	17
Unravelling the molecular mechanisms of prostate cancer evolution from genotype to phenotype	17
BRAF as a positive predictive biomarker: Focus on lung cancer and melanoma patients	17
Current advances in PD-1/PD-L1 axis-related tumour-infiltrating immune cells and therapeutic regimens in glioblastoma	17
Telemedicine and the current opportunities for the management of oncological patients in Peru in the context of COVID-19 pandemic	17
Cytoskeletal proteins as glioblastoma biomarkers and targets for therapy: A systematic review	17
Cancer management during the COVID-19 pandemic: Choosing between the devil and the deep blue sea	17
Carotid blowout syndrome after reirradiation for head and neck malignancies: a comprehensive systematic review for a pragmatic multidisciplinary approach	17
Exosomics in oral cancer diagnosis, prognosis, and therapeutics – An emergent and imperative non-invasive natural nanoparticle-based approach	17
Effectiveness of low level laser therapy versus cryotherapy in cancer patients with oral mucositis: Systematic review and network meta-analysis	17
Self-expandable metal stent (SEMS) placement or emergency surgery as palliative treatment for obstructive colorectal cancer: A systematic review and meta-analysis	17
Surgical treatment of gastric cancer liver metastases: Systematic review and meta-analysis of long-term outcomes and prognostic factors	16
The extracellular matrix in colorectal cancer and its metastatic settling – Alterations and biological implications	16
Type I interferons in pancreatic cancer and development of new therapeutic approaches	16
Therapeutic potential of p53 reactivation in cervical cancer	16
MYB-NFIB fusion transcript in adenoid cystic carcinoma: Current state of knowledge and future directions	16
In vivo sentinel lymph node identification using fluorescent tracer imaging in colon cancer: A systematic review and meta-analysis	16
Invadopodia: A potential target for pancreatic cancer therapy	16
Considerations for interactions of drugs used for the treatment of COVID-19 with anti-cancer treatments	16
Does laser photobiomodulation prevent hyposalivation in patients undergoing head and neck radiotherapy? A systematic review and meta-analysis of controlled trials	16
New perspectives in genetics and targeted therapy for blastic plasmacytoid dendritic cell neoplasm	16
State of the art of radiomic analysis in the clinical management of prostate cancer: A systematic review	16
A scoping review to map the evidence of physical activity interventions in post-treatment adolescent and young adult cancer survivors	16
How much is too much? Systematic review of cumulative doses from radiological imaging and the risk of cancer in children and young adults	16
The role of cardio-protective agents in cardio-preservation in breast cancer patients receiving Anthracyclines ± Trastuzumab: a Meta-analysis of clinical studies	16
Electrolyte disorders in advanced non-small cell lung cancer patients treated with immune check-point inhibitors: A systematic review and meta-analysis	16
Uterine carcinosarcoma: An overview	16
The diverse molecular profiles of lynch syndrome-associated colorectal cancers are (highly) dependent on underlying germline mismatch repair mutations	16
Managing side effects of immune checkpoint inhibitors in breast cancer	16
Outcome of patients with advanced upper tract urothelial carcinoma treated with immune checkpoint inhibitors: A systematic review and meta-analysis	16
NOTCH signaling: Journey of an evolutionarily conserved pathway in driving tumor progression and its modulation as a therapeutic target	16
The cyclin-dependent kinases pathway as a target for prostate cancer treatment: rationale and future perspectives	15
Targeting acute myeloid leukemia stem cells: Current therapies in development and potential strategies with new dimensions	15
Radiation recall reactions: An oncologic enigma	15
Osteosarcoma of the jaws: An overview of the pathophysiological mechanisms	15
Side effects of using granulocyte-colony stimulating factors as prophylaxis of febrile neutropenia in cancer patients: A systematic review	15
Toxicity of extended adjuvant endocrine with aromatase inhibitors in patients with postmenopausal breast cancer: A Systemtic review and Meta-analysis	15
Serum tumour markers in germ cell tumours: From diagnosis to cure	15
Implications of COVID-19 pandemic on lung cancer management: A multidisciplinary perspective	15
Association of periodontitis and tooth loss with liver cancer: A systematic review	15
Late radiation effects in survivors of head and neck cancer: State of the science	15
The role of immune checkpoint inhibitors in the treatment sequence of advanced gastric or gastro-esophageal junction cancer: A systematic review and meta-analysis of randomized trials	15
Hype or hope – Can combination therapies with third-generation EGFR-TKIs help overcome acquired resistance and improve outcomes in EGFR-mutant advanced/metastatic NSCLC?	15
Daratumumab-based induction therapy for multiple myeloma: A systematic review and meta-analysis	15
Diet derived polycyclic aromatic hydrocarbons and its pathogenic roles in colorectal carcinogenesis	14
Iron overload-induced oxidative stress in myelodysplastic syndromes and its cellular sequelae	14
Exploring the knowledge gap of immune checkpoint inhibitors in chronic renal failure: A systematic review of the literature	14
Risk of bleeding complications and atrial fibrillation associated with ibrutinib treatment: A systematic review and meta-analysis	14
Circulating tumor cell detection methods in renal cell carcinoma: A systematic review	14
Radiotherapy based management during Covid-19 pandemic – A systematic review of presented consensus and guidelines	14
Current concepts and future directions for hemato-oncologic diagnostics	14
miRNA as promising theragnostic biomarkers for predicting radioresistance in cancer: A systematic review and meta‐analysis	14
Molecular landscape of Hereditary Melanoma	14
Imaging response evaluation after neoadjuvant treatment in soft tissue sarcomas: Where do we stand?	14
Role of innate and adaptive immunity in the efficacy of anti-HER2 monoclonal antibodies for HER2-positive breast cancer	14
Bleeding with vascular endothelial growth factor tyrosine kinase inhibitor: A network meta-analysis	14
Milestones in the treatment of hepatocellular carcinoma: A systematic review.	14
Current treatment options for HER2-positive breast cancer patients with brain metastases	14
Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors	14
Near-InfraRed PhotoImmunoTherapy (NIR-PIT) for the local control of solid cancers: Challenges and potentials for human applications	14
Protective effects of physical activity in colon cancer and underlying mechanisms: A review of epidemiological and biological evidence	14
Bipolar androgen therapy in prostate cancer: Current evidences and future perspectives	13
Effectiveness of cognitive behavioral therapy in improving functional health in cancer survivors: A systematic review and meta-analysis	13
Association between telomere length and mitochondrial copy number and cancer risk in humans: A meta-analysis on more than 300,000 individuals	13
Role of stereotactic radiosurgery for the treatment of brain metastasis in the era of immunotherapy: A systematic review on current evidences and predicting factors	13
Addition of immunotherapy to chemotherapy for metastatic triple-negative breast cancer: A systematic review and meta-analysis of randomized clinical trials	13
Which treatment after first line therapy in NSCLC patients without genetic alterations in the era of immunotherapy?	13
Neoadjuvant immunotherapy in head and neck cancer: Rationale, current evidence and future perspective	13
Radioimmunotherapy of glioblastoma multiforme - Current status and future prospects	13
Size distribution of cell-free DNA in oncology	13
Fertility preservation in women with cervical cancer	13
Effectiveness of photobiomodulation therapy in radiation dermatitis: A systematic review and meta-analysis	13
Unraveling molecular mechanisms of head and neck cancer	13
Worldwide prevalence of PI3K-AKT-mTOR pathway mutations in head and neck cancer: A systematic review and meta-analysis	13
Advanced and recurrent endometrial cancer: State of the art and future perspectives	13
A systematic review and meta-analysis of trials assessing PD-1/PD-L1 immune checkpoint inhibitors activity in pre-treated advanced stage malignant mesothelioma	13
Ethnicity as modifier of risk for Vitamin D receptors polymorphisms: Comprehensive meta-analysis of all cancer sites	13
Critical review of oncology clinical trial design under non-proportional hazards	13
Efficacy and safety of novel oral anticoagulants versus low molecular weight heparin in cancer patients with venous thromboembolism: A systematic review and meta-analysis	13
Advances in adjuvant therapy of biliary tract cancer: an overview of current clinical evidence based on phase II and III trials	13
Metabolic disorders and gastroenteropancreatic-neuroendocrine tumors (GEP-NETs): How do they influence each other? An Italian Association of Medical Oncology (AIOM)/ Italian Association of Medical Dia	13
Recommendations for detection, prioritization, and treatment of thoracic oncology patients during the COVID‐19 pandemic: the THOCOoP cooperative group	13
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib	13