Critical Reviews in Oncology Hematology

Article	Citations
Harnessing tumor metabolism during cancer treatment: A narrative review of emerging dietary approaches	292
Efficacy of PD-1/PD-L1 immunotherapy on brain metastatic non-small-cell lung cancer and treatment-related adverse events: A systematic review	193
A bone paradigm challenging the standard model of myeloma oncogenesis	148
Dysregulation of systemic immunity in colorectal cancer and its clinical applications as biomarkers and therapeutics	133
Stereotactic body radiotherapy as an alternative to brachytherapy in cervical cancer (SCORE): A systematic review and meta-analysis	128
Double agents in immunotherapy: Unmasking the role of antibody drug conjugates in immune checkpoint targeting	112
Direct and indirect effects on child neurocognitive development when maternal cancer is diagnosed during pregnancy: What do we know so far?	103
Editorial Board	93
Surface-Enhanced Raman Scattering (SERS) combined with machine learning enables accurate diagnosis of cervical cancer: From molecule to cell to tissue level	90
Novel bioengineered drugs with immunotherapies for malignant pleural effusion: Remodulate tumor immune microenvironment and activate immune system	89
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part II	80
The BCL-2–tumor microenvironment axis: Mechanisms of immune suppression, resistance, and pathways to therapeutic reprogramming	77
Letter to the Editor regarding the article “A net-work meta-analysis of the cardiac safety for next-generation hormonal agents in treating castration-resistant prostate cancer: How to choose drugs app	75
Skin barrier dysfunction in cutaneous T-cell lymphoma: From pathogenic mechanism of barrier damage to treatment	75
Mapping the research landscape of HPV-positive oropharyngeal cancer: a bibliometric analysis	70
Instruments and scales for the evaluation of acute radiation dermatitis: A systematic review	69
Navigating management of localized prostate cancer in the geriatric population	63
Systemic immune-inflammation index as a predictor of survival in non-small cell lung cancer patients undergoing immune checkpoint inhibition: A systematic review and meta-analysis	62
Development of treatment strategies for advanced HER2-positive gastric cancer: Insights from clinical trials	61
Targeted doublet therapy with encorafenib and cetuximab for BRAF V600E-mutant metastatic colorectal cancer: A systematic review and meta-analysis	55
Beyond monospecificity: The modular revolution of bispecific immunotherapeutics	54
Unveiling the Role of JAK2/STAT3 signaling in chemoresistance of gynecological cancers: From mechanisms to therapeutic implications	51
Stereotactic body radiation therapy versus conventional external beam radiation therapy for painful bone metastases: A systematic review and meta-analysis of randomized trials	50
Real-world analysis of primary central nervous system diffuse large B-cell lymphoma	49
Comparative efficacy of first-line therapies for PD-L1-negative advanced NSCLC: A network meta-analysis with reconstructed survival curves	49

Microbiome dynamics in breast cancer: Mechanisms, therapeutic impacts and research gaps	49
Total neoadjuvant treatment and organ preservation strategies in the management of localized rectal cancer: A narrative review and evidence-based algorithm	48
Beyond the blood-brain barrier: Intranasal vaccines in cancer immunotherapy	48
Microbiome and lung cancer: carcinogenic mechanisms, early cancer diagnosis, and promising microbial therapies	48
The hidden hand of endoplasmic reticulum stress in anticancer drug resistance	46
The role of cGAS-STING in remodeling the tumor immune microenvironment induced by radiotherapy	44
From immunohistochemistry to machine learning-based patient stratification by tumour proliferation characteristics in head and neck cancer	43
Advancing tumor vaccines: Overcoming TME challenges, delivery strategies, and biomaterial-based vaccine for enhanced immunotherapy	42
Next generation diagnostic algorithm in non-small cell lung cancer predictive molecular pathology: The KWAY Italian multicenter cost evaluation study	41
A non-invasive miRNA-based approach in early diagnosis and therapeutics of oral cancer	41
Open issues in the therapeutic management of unresectable stage III NSCLC in the immunotherapy era	40
The cytokines in tumor microenvironment: from cancer initiation-elongation-progression to metastatic outgrowth	39
Apigenin in cancer prevention and therapy: A systematic review and meta-analysis of animal models	39
Innovations in cancer immunotherapy: A comprehensive overview of recent breakthroughs and future directions	38
Current status of locally advanced rectal cancer therapy and future prospects	38
Novel insight into the Warburg effect: Sweet temptation	38
Trastuzumab deruxtecan: Redefining precision oncology across HER2-driven cancers	36
Management of secondary immunodeficiency in hematological malignancies in the era of modern oncology	36
Prognostic value of HER2 discordance between primary and metastatic or recurrent breast cancer: A systematic review and meta-analysis	35
The biology and treatment of leiomyosarcomas	34
Predictive models for immune checkpoint inhibitor response in cancer: A review of current approaches and future directions	34
Impact of Adding Immune Checkpoint Inhibitors to Standard Therapies in Non-Small Cell Lung Cancer: A Systematic Review of Efficacy Outcomes	34
Predictive factors for return to work among cancer survivors in Europe: A systematic review	34
KRAS mutated colorectal cancers with or without PIK3CA mutations: Clinical and molecular profiles inform current and future therapeutics	34
Immuno-oncology therapy in metastatic bladder cancer: A systematic review and network meta-analysis	34
Effect of exercise on functional capacity in patients with advanced cancer: A meta-analysis of randomized controlled trials	32
Immunotherapy in OSCC: Current trend and challenges	32
Editorial Board	31
Pressurised intraperitoneal aerosolised chemotherapy (PIPAC) for gastric cancer with peritoneal metastases: A systematic review by the PIPAC UK collaborative	31
Cellular and molecular mechanisms implicated in the dual role of ROR2 in cancer	31
Comment on “The risk of breast cancer and gynecologic malignancies after ovarian stimulation: Meta-analysis of cohort study”	31
Editorial Board	31
ESO's career development program (2002-2021): Presentation and evaluation	30
Targeting hypoxia-inducible factor pathways in sporadic and Von Hippel-Lindau syndrome-related kidney cancers	30
Can inflammasomes promote the pathophysiology of glioblastoma multiforme? A view about the potential of the anti-inflammasome therapy as pharmacological target	30
TIGIT: Will it be the next star therapeutic target like PD-1 in hematological malignancies?	29
Thrombosis and cachexia in cancer: Two partners in crime?	29
Adjuvant immunotherapy in high-risk renal cell carcinoma: Indications, limitations, and perspectives. A consensus statement from the GIOTTO uro-oncology group	29
Next-generation immunotherapy in relapsed/refractory multiple myeloma: Strategies to achieve sustained MRD negativity	29
Chemotherapy, immunotherapy, and targeted therapy for osteosarcoma: Recent advancements	28
Comparative analysis of systemic treatment with or without immune checkpoint inhibitors for advanced or recurrent endometrial cancer: A systematic review and meta-analysis of randomized controlled tri	28
UGT1A1 Testing in Breast Cancer: should it become routine practice in patients treated with antibody-drug conjugates?	28
Optimal treatment strategy for central nervous system non-germinomatous germ cell tumors: A systematic review and meta-analysis	28
First-line treatments for advanced or recurrent endometrial cancer: Systematic literature review of clinical evidence	28
The role of GPI-anchored LY6/uPAR family proteins in connecting membrane microdomains with immune regulation and diseases	28
Neoadjuvant therapy for muscle-invasive bladder cancer: Current clinical scenario, future perspectives, and unsolved questions	28
Exosomes derived from cancer-associated fibroblasts mediate response to cancer therapy	28
Minimal residual disease testing for classical Hodgkin lymphoma: A comprehensive review	27
Advantages and drawbacks of dexamethasone in glioblastoma multiforme	27
Clinical trials for patients with salivary gland cancers: A systematic review of worldwide registers and an evaluation of current challenges	27

CAR T-cell therapy landscape in pediatric, adolescent and young adult oncology – A comprehensive analysis of clinical trials	27
Efficacy and safety of targeted therapy and immunotherapy in advanced vulvar squamous cell carcinoma: A scoping review	27
The role and clinical significance of tumor-draining lymph nodes in tumor progression and immunotherapy	26
Unlocking the potential of Molecular Tumor Boards: from cutting-edge data interpretation to innovative clinical pathways	26
Prognostic scores including peripheral blood-derived inflammatory indices in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors	26
Challenges facing CAR T-cell immunotherapy in multiple myeloma	25
Antibody-oligonucleotide conjugates in cancer therapy: Potential and Promise	25
The role of central nervous system (CNS) prophylaxis in preventing DLBCL patients from CNS relapse: A network meta-analysis	25
Unveilling the potential of liquid biopsy in pancreatic cancer for molecular diagnosis and treatment guidance	25
Quantifying absolute benefit for adjuvant treatment options in renal cell carcinoma: A living interactive systematic review and network meta-analysis	25
The role of liquid biopsy in epithelial ovarian cancer: State of the art	25
Synergistic effects of immunotherapy and adjunctive therapies in prostate cancer management	25
Neoadjuvant Therapy in Ovarian Cancer: Emerging Paradigms and Therapeutic Frontiers	24
Efficacy of stereotactic radiosurgery as single or combined therapy for brain metastasis: A systematic review and meta-analysis	24
The extracellular matrix in colorectal cancer and its metastatic settling – Alterations and biological implications	24
Editorial Board	24
The peripheral tumor neuro-microenvironment: Deciphering neural landscape and mechanistic insights for therapeutic innovation	24
A comprehensive review on targeting diverse immune cells for anticancer therapy: Beyond immune checkpoint inhibitors	23
Salvage radiotherapy after initial cryotherapy for localized prostate cancer: A systematic review of the literature	23
Editorial Board	23
DLL3 as a potential diagnostic and therapeutic target in neuroendocrine neoplasms: A narrative review	23
Unraveling molecular mechanisms of head and neck cancer	23
Advancing CAR-T cell manufacturing in Latin America: Current landscape, future directions, and challenges	23
The association between paraneoplastic neurological syndromes (PNS) and urothelial carcinoma – A review of the literature	23
Drug-based therapy for advanced adenoid cystic carcinoma: Current landscape and challenges based on an overview of registered clinical trials	23
Unlock the code of MHC II-enabled Cancer immunotherapy	22
Revolutionizing immunotherapy: The next frontier in CAR T-cell engineering	22
Decoding the puzzle: A multidisciplinary systematic review of adult brainstem glioma	22
Role of radiation in chimeric antigen receptor T-cell therapy for patients with relapsed/refractory non-Hodgkin lymphoma: Current studies and future prospects	22
Cardio-oncology concerns in radiotherapy: Heart and cardiac substructure toxicities from modern delivery techniques	22
Rethinking treatment paradigms: Neoadjuvant therapy and de-escalation strategies in HPV-positive head and neck cancer	22
Plasmonic surgery: SERS-active smart nanotools reshaping intraoperative decision-making and precision therapy	22
Towards a new approach in pleural mesothelioma: Perioperative immunotherapy and its implications	21
Strategies to overcome chemoresistance in epithelial ovarian cancer: Navigating beyond challenges	21
Editorial Board	21
RNA N4-acetylcytidine modification in gastrointestinal cancer: Novel functions, mechanisms, and therapeutic implications	21
Sialylated glycoproteins and sialyltransferases in digestive cancers: Mechanisms, diagnostic biomarkers, and therapeutic targets	21
Recent advances and research progress in biomarkers for chronic graft versus host disease	21
Combining gut microbiota modulation and immunotherapy: A promising approach for treating microsatellite stable colorectal cancer	21
Facing the climate change: Is radiotherapy as green as we would like? A systematic review	21
Epigenetic mechanisms of PARP inhibitor resistance in ovarian cancer: A systematic review with bioinformatic analysis of clinically actionable genes	21
Artificial intelligence in NSCLC management for revolutionizing diagnosis, prognosis, and treatment optimization: A systematic review	21
The pH perspective of cancer: From warburg's misconception to therapeutic targeting of pH regulating proteins	21
Comprehensive review of signaling pathways and therapeutic targets in gastrointestinal cancers	21
Pathology, immunosuppression and NK cell immunotherapy of non-small cell lung cancer	21
Recent development in bispecific antibody immunotherapy for hematological malignancies	20
Epigenetic-modifying agents: The potential game changers in the treatment of hematologic malignancies	20
Safety and efficacy of liposomal irinotecan as the second-line treatment for advanced pancreatic cancer: A systematic review and meta-analysis	20
Artificial intelligence: A promising frontier in bladder cancer diagnosis and outcome prediction	20
Long-term strategies for management of advanced basal cell carcinoma with hedgehog inhibitors	20
Personalized medicine for metastatic prostate cancer: The paradigm of PARP inhibitors	20
Targeting TIME in advanced hepatocellular carcinoma: Mechanisms of drug resistance and treatment strategies	20
« Augmented radiotherapy » in the management of high-risk prostate cancer (PCa): A systematic review	20
Association between bevacizumab with cancer drug therapies and drug-induced interstitial lung disease in patients with solid tumor: A systematic review and meta-analysis of randomized clinical trials	19
Deciphering the possible reciprocal loop between hepatic stellate cells and cancer cells in the tumor microenvironment of the liver	19
Rare histotypes of epithelial biliary tract tumors: A literature review	19
Radiotherapy of high-grade gliomas: dealing with a stalemate	19
The impact of survivorship bias in glioblastoma research	19
Navigating chemotherapy and immunotherapy in early-stage lung cancer. A critical review and statements from INTERACTION group	19
The diagnostic accuracy of single-item scales in detecting fatigue in patients with cancer: A systematic review and meta-analysis	19
Biomarkers in blood and saliva to screen fragile patients with solid tumors: A systematic review of the literature	19
Clonal hematopoiesis of indeterminate potential (CHIP): A potential contributor to lymphoma	18
IHC-based molecular classification in muscle-invasive urothelial bladder carcinoma: Prognostic and predictive value toward a clinically applicable IHC marker panel – A systematic review	18
Delta-like ligand 3 in small cell lung cancer: Potential mechanism and treatment progress	18
Androgen annihilation versus advanced androgen blockage as first line treatment for metastatic castration resistant prostate cancer: A systematic review and meta-analysis	18
A scoping review to map the evidence of physical activity interventions in post-treatment adolescent and young adult cancer survivors	18
Can the tumor-agnostic evaluation of MSI/MMR status be the common denominator for the immunotherapy treatment of patients with several solid tumors?	18
Testicular germ cell tumors: Genomic alternations and RAS-dependent signaling	18
Current landscape of hypoxia in thyroid cancer pathogenesis and treatment	18
Molecular oncology of iodine refractory thyroid cancer current therapies and perspective	18
Anticancer mechanisms and applications based on γδ T cells in cancer immunotherapy	18
Is it a new era for intrahepatic cholangiocarcinoma?	18
Prognostic value of CD49d in CLL: Systematic review and meta-analysis	18
Prospects of targeting PI3K/AKT/mTOR pathway in pancreatic cancer	18
The crosstalk of the human microbiome in breast and colon cancer: A metabolomics analysis	18
Endometrial cancer in the elderly: Characteristics, prognostic and risk factors, and treatment options	18
Role of innate immunity in tumor microenvironment of HPV-associated anal cancer: The hypothetical beneficial role of γδ T cells.	18
The relationship between LDH and GLIM criteria for cancer cachexia: Systematic review and meta-analysis	18
N6-methyladenosine-dependent signaling in colorectal cancer: Functions and clinical potential	17
Circular RNAs as key regulators in cancer hallmarks: New progress and therapeutic opportunities	17

Evaluation of clinical decision support systems in oncology: An updated systematic review	17
Combine radiotherapy and immunotherapy in esophageal squamous cell carcinoma	17
Immune checkpoint inhibitors as a threat to reproductive function: A systematic review	17
Radiosensitization strategies for hepatocellular carcinoma: Mechanisms, therapeutic advances, and clinical perspectives	17
Targeting breast cancer stem cells through retinoids: A new hope for treatment	17
Elucidating the mechanistic role of ovarian cancer biomarkers: Lessons learnt from affinity-proteomics	17
Symptomatologic outcomes of gut microbiota modifiers (probiotics, prebiotics and synbiotics) in cancer care: A scoping review of randomized controlled trials	17
Next-Generation models of Gallbladder Carcinoma: Linking biological insights to precision medicine	17
Uncovering the bookshelves of CRISPR-based libraries: Advances and applications in cancer studies	17
Incidence of antibody–drug conjugates-related pneumonitis in patients with solid tumors: A systematic review and meta-analysis	17
Management of patients with extensive small-cell lung cancer in the immunotherapy era: An Italian consensus through a Delphi approach	16
Profile of treatment-related adverse events of PD-1 blockade-based therapies in advanced esophageal cancer: A systematic review and meta-analysis	16
Epidermal growth factor receptor exon 20 insertion variants in non-small cell lung cancer patients	16
Editorial Board	16
Outcome after treatment with axitinib in children, young adults, and adults with renal cell carcinoma: a narrative review	16
Venous thromboembolism in cancer and cancer immunotherapy	16
The current landscape of systemic therapy for recurrent glioblastoma: A systematic review of randomized-controlled trials	16
Molecular mechanisms of ferroptosis and its role in prostate cancer therapy	16
Spatial transcriptomics in pancreatic cancer: Advances, prospects and challenges	16
Status of breast cancer in Latin American: Results of the breast cancer revealed initiative	16
Tyrosine kinase inhibitors in cancers: Treatment optimization – Part I	16
The role of the SIX family in cancer development and therapy: Insights from foundational and cutting-edge research	16
Editorial Board	16
Evidence-based recommendations for induction and maintenance treatment of newly diagnosed transplant-ineligible multiple myeloma patients	16
The educational contribution of the college of the European school of oncology (ESCO): A survey analysis of the first three years	16
A neuroendocrine biomarker revolution from monoanalyte to multianalyte biomarkers in non-functioning gastro-entero-pancreatic neuroendocrine neoplasms	16
Protective effects of physical activity in colon cancer and underlying mechanisms: A review of epidemiological and biological evidence	16
WEE1 inhibition in cancer therapy: Mechanisms, synergies, preclinical insights, and clinical trials	15
Which is the best treatment for melanoma brain metastases? A Bayesian network meta-analysis and systematic review	15
Venetoclax and ibrutinib: Two partners for the front-line treatment of chronic lymphocytic leukemia	15
Standardized molecular pathology workflow for ctDNA-based ESR1 testing in HR+/HER2- metastatic breast cancer	15
The influence of genetic variation on late effects in childhood cancer survivors: An updated systematic review	15
The application of stepped-wedge cluster-randomized controlled trial study designs in oncology settings: A systematic review	15
Cardiovascular safety outcomes of chronic lymphocytic leukemia treatments: A systematic and targeted literature review	15
Metaplastic breast cancer: A review	15
The study of primary and acquired resistance to first-line osimertinib to improve the outcome of EGFR-mutated advanced Non-small cell lung cancer patients: the challenge is open for new therapeutic st	15
Additions and subtractions of radiotherapy in patients with oligometastatic non-small cell lung cancer under the era of immunotherapy	15
Exploring the molecular interactions between ferroptosis and the Wnt/β-catenin signaling pathway: Implications for cancer and disease therapy	15
Dynamic interplay of neuroendocrine signaling and immuno-surveillance in tumor niche remodeling	15
Somatic and germline ATM variants in non-small-cell lung cancer: Therapeutic implications	15
Chimeric antigen receptor T cell immunotherapy for gynecological malignancies	15
Safety assessment of antibody-drug conjugates: Nonclinical toxicology, non-active ingredients, and environmental risk considerations	15
Significance of HOXD transcription factors family in progression, migration and angiogenesis of cancer	15
Fatty acid in the tumor microenvironment: Perspectives for immunotherapy	15
Polyploid giant cancer cells: Underlying mechanisms, signaling pathways, and therapeutic strategies	15
The roles of immune cells and non-immune cells in pre-metastatic niche of breast cancer	15
KRAS G12C-mutant driven non-small cell lung cancer (NSCLC)	15
Expanding horizons in cancer therapy by immunoconjugates targeting tumor microenvironments	15
Stereotactic body radiotherapy boost as an alternative to brachytherapy for cervical cancer: A scoping review	15
The impact of PARP inhibitors in the whole scenario of ovarian cancer management: A systematic review and network meta-analysis	15
Extrachromosomal DNA in cancer: Molecular mechanisms underlying oncogene amplification and tumor heterogeneity	15
Neoadjuvant endocrine therapy for luminal breast tumors: State of the art, challenges and future perspectives	14
HER2-targeted therapies: Unraveling their role in biliary tract cancers	14
Advancing patient setup: A comprehensive scoping review of tattoo-less techniques in radiation therapy	14
Real-world insights into the efficacy and safety of tyrosine kinase inhibitors against thyroid cancers	14
Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies	14
Evolving treatment for advanced non-small cell lung cancer harbouring common EGFR activating mutations	14
Targeting the DNA damage response to enhance radiotherapy in soft tissue sarcomas	14
Clonal hematopoiesis and inflammation: A review of mechanisms and clinical implications	14
Belgian expert consensus for tumor-agnostic treatment of NTRK gene fusion-driven solid tumors with larotrectinib	14
Radioprotective agents against the ionizing radiation-induced hematopoietic stem and progenitor cell injury; Foundation review	14
The impact of gender on The efficacy of immune checkpoint inhibitors in cancer patients: The MOUSEION-01 study	14
Is antibody-drug conjugate a rising star for clinical treatment of solid tumors? A systematic review and meta-analysis	14
Epigenetics in advanced renal cell carcinoma: Potential new targets	14
Comment on: Predictors of prognosis and overall survival in pediatric mucoepidermoid carcinoma of salivary glands	14
Effect of non-pharmacological interventions on symptoms and quality of life in patients with hematological malignancies – A systematic review	14
The application of cancer stem cell model in malignant mesothelioma	13
Factors for a broad technology assessment of comprehensive genomic profiling in advanced cancer, a systematic review	13
Diagnosis and treatment of therapy-related acute myeloid leukemia	13
The effects of race on anti-PD-(L)1 monoclonal antibodies in non-small cell lung cancer: A systematic literature review and meta-analysis	13
Warming-up the immune cell engagers (ICEs) era in breast cancer: state of the art and future directions	13
Advancements in tumor-infiltrating lymphocytes: Historical insights, contemporary milestones, and future directions in oncology therapy	13
Unlocking the intricacies: Exploring the complex interplay between platelets and ovarian cancer	13
The prevalence of solid tumors and hematologic malignancies among patients with Down syndrome: A systematic review and meta-analysis	13
Erratum to “Beyond the blood-brain barrier: Intranasal vaccines in cancer immunotherapy” [Crit. Rev. Oncol./Hematol. 216C (2025) 104938]	13
Application of molecular imaging in immune checkpoints therapy: From response assessment to prognosis prediction	13
Comment on “A systematic review and meta-analysis of PD-1/PD-L1 inhibitors in specific patient subgroups with advanced gastro-oesophageal junction and gastric adenocarcinoma”	13
KRAS mutations in advanced non-small cell lung cancer: From biology to novel therapeutic strategies	13
Bladder-sparing treatment for muscle-invasive bladder carcinoma using immune checkpoint inhibitors	13
Optimizing management of cutaneous toxicities from amivantamab in first-line non-small cell lung cancer: A clinical perspective	13
Relationship between purinergic signalling and oxidative stress in prostate cancer: Perspectives for future therapy	13
Long non-coding RNAs as immune landscape regulators in cancer: A spotlight on HEIH in immuno-oncology	13
Cardiac and vascular toxicity of amivantamab in non-small cell lung cancer (NSCLC): A systematic review	13
International consensus on the initial diagnostic workup of cancer of unknown primary	13
Patients’ selection and trial matching in early-phase oncology clinical trials	13
Perioperative imaging predictors of tumor progression and pseudoprogression: A systematic review	13
Advanced and recurrent endometrial cancer: State of the art and future perspectives	13
The potential of circulating cell-free RNA in CNS tumor diagnosis and monitoring: A liquid biopsy approach	12
Transarterial radioembolization in neuroendocrine liver metastases 25 years later: A systematic review	12
Key considerations for a prostate cancer mRNA vaccine	12
Molecular features and clinical actionability of gene fusions in colorectal cancer	12
Small cell lung cancer unveiled: Exploring the untapped resource of circulating tumor cells-derived organoids	12
Prognostic and therapeutic potential of STAT3: Opportunities and challenges in targeting HPV-mediated cervical carcinogenesis	12
Cellular senescence in tumor immune escape: Mechanisms, implications, and therapeutic potential	12
Insights into Sorafenib resistance in hepatocellular carcinoma: Mechanisms and therapeutic aspects	12