OOIR: Observatory of International Research

Papers

(The TQCC of Bioconjugate Chemistry is 9. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Bioorthogonal Chemistry and Its Applications	130
The Biomolecular Corona of Lipid Nanoparticles for Gene Therapy	123
An Overview of Recent Advances in Biomedical Applications of Click Chemistry	98
Nanoparticle-Based Wound Dressing: Recent Progress in the Detection and Therapy of Bacterial Infections	90
Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV-2	69
Synthetic ECM: Bioactive Synthetic Hydrogels for 3D Tissue Engineering	67
Gold Nanoclusters: Imaging, Therapy, and Theranostic Roles in Biomedical Applications	65
Copper-Doped Nanoscale Covalent Organic Polymer for Augmented Photo/Chemodynamic Synergistic Therapy and Immunotherapy	62
MOFs-Derived Fe–N Codoped Carbon Nanoparticles as O₂-Evolving Reactor and ROS Generator for CDT/PDT/PTT Synergistic Treatment of Tumors	59
Comprehensive Review on Current Interventions, Diagnostics, and Nanotechnology Perspectives against SARS-CoV-2	58
In Situ One-Step Fluorescence Labeling Strategy of Exosomes via Bioorthogonal Click Chemistry for Real-Time Exosome Tracking In Vitro and In Vivo	58
3D Bioprinting of Bone Marrow Mesenchymal Stem Cell-Laden Silk Fibroin Double Network Scaffolds for Cartilage Tissue Repair	57
Fluorescent Labeling of Proteins of Interest in Live Cells: Beyond Fluorescent Proteins	54
Hyaluronic Acid-Modified Au–Ag Alloy Nanoparticles for Radiation/Nanozyme/Ag⁺ Multimodal Synergistically Enhanced Cancer Therapy	45
Radiolabeled Peptides and Antibodies in Medicine	43
Overview of Antibacterial Strategies of Dental Implant Materials for the Prevention of Peri-Implantitis	43
Quaternary Ammonium Salts: Insights into Synthesis and New Directions in Antibacterial Applications	41
The Potential of Various Nanotechnologies for Coronavirus Diagnosis/Treatment Highlighted through a Literature Analysis	41
Design and Application of Receptor-Targeted Fluorescent Probes Based on Small Molecular Fluorescent Dyes	40
Recent Advances in Bioorthogonal Click Chemistry for Biomedical Applications	39
Dendrimers toward Translational Nanotherapeutics: Concise Key Step Analysis	38
Heptamethine Cyanine Dye Mediated Drug Delivery: Hype or Hope	38
Gold/Silver Hybrid Nanoparticles with Enduring Inhibition of Coronavirus Multiplication through Multisite Mechanisms	37
Site-Specific Bioconjugation Approaches for Enhanced Delivery of Protein Therapeutics and Protein Drug Carriers	37
Ultrastable PEGylated Calixarene-Coated Gold Nanoparticles with a Tunable Bioconjugation Density for Biosensing Applications	37

State of the Art in Radiolabeling of Antibodies with Common and Uncommon Radiometals for Preclinical and Clinical Immuno-PET	37
Synthetic Multienzyme Complexes Assembled on Virus-like Particles for Cascade Biosynthesis In Cellulo	36
Recent Advances in Croconaine Dyes for Bioimaging and Theranostics	35
Surface Biomodification of Liposomes and Polymersomes for Efficient Targeted Drug Delivery	32
Powerful Chemiluminescence Probe for Rapid Detection of Prostate Specific Antigen Proteolytic Activity: Forensic Identification of Human Semen	31
Bioconjugate Supramolecular Pd²⁺ Metallacages Penetrate the Blood Brain Barrier In Vitro and In Vivo	31
PET/Fluorescence Imaging: An Overview of the Chemical Strategies to Build Dual Imaging Tools	30
Fluorescent Bioconjugates for Super-Resolution Optical Nanoscopy	29
Lipopeptides for Vaccine Development	29
Mitochondrial Targeting of Probes and Therapeutics to the Powerhouse of the Cell	28
Engineering Self-Assembling Protein Nanoparticles for Therapeutic Delivery	28
Optimized Methods for the Production and Bioconjugation of Site-Specific, Alkyne-Modified Glucagon-like Peptide-1 (GLP-1) Analogs to Azide-Modified Delivery Platforms Using Copper-Catalyzed Alkyne–Azi	28
NIR-II Functional Materials for Photoacoustic Theranostics	28
New Lipophilic Fluorescent Dyes for Labeling Extracellular Vesicles: Characterization and Monitoring of Cellular Uptake	27
Full Color Tunable Aggregation-Induced Emission Luminogen for Bioimaging Based on an Indolizine Molecular Framework	27
PEGylated Lipid Nanoparticle Formulations: Immunological Safety and Efficiency Perspective	26
Covalent Organic Framework–Titanium Oxide Nanocomposite for Enhanced Sonodynamic Therapy	26
Redox-Responsive Hydrogels for Tunable and “On-Demand” Release of Biomacromolecules	26
Precision Modification of Native Antibodies	26
Bacteriophage Capsid Modification by Genetic and Chemical Methods	25
A Platform for the Generation of Site-Specific Antibody–Drug Conjugates That Allows for Selective Reduction of Engineered Cysteines	24
Tandem-Cleavage Linkers Improve the In Vivo Stability and Tolerability of Antibody–Drug Conjugates	24
Self-Assembling Nanoparticle Vaccines Displaying the Receptor Binding Domain of SARS-CoV-2 Elicit Robust Protective Immune Responses in Rhesus Monkeys	24
Catalytic Nanozyme for Radiation Protection	23
Cysteine-Based Coupling: Challenges and Solutions	23
Recent Breakthrough in ⁶⁸Ga-Radiopharmaceuticals Cold Kits for Convenient PET Radiopharmacy	23
Peptide-Chitosan Engineered Scaffolds for Biomedical Applications	23
Spherical Nucleic Acid Mediated Functionalization of Polydopamine-Coated Nanoparticles for Selective DNA Extraction and Detection	23
Gold Nanoclusters-Decorated Zeolitic Imidazolate Frameworks with Reactive Oxygen Species Generation for Photoenhanced Antibacterial Study	23
Penetrating the Blood-Brain Barrier with New Peptide–Porphyrin Conjugates Having anti-HIV Activity	23
Shortwave-Infrared Fluorescent Molecular Imaging Probes Based on π-Conjugation Extended Indocyanine Green	22
Anchor, Spacer, and Ligand-Modified Engineered Exosomes for Trackable Targeted Therapy	22
High-Affinity Points of Interaction on Antibody Allow Synthesis of Stable and Highly Functional Antibody–Gold Nanoparticle Conjugates	22
Protein Delivery: If Your GFP (or Other Small Protein) Is in the Cytosol, It Will Also Be in the Nucleus	22
Molecular Imaging-Guided Sonodynamic Therapy	22
Supramolecular “Click Chemistry” for Targeting in the Body	22
Electrostatic Conjugation of Nanoparticle Surfaces with Functional Peptide Motifs	21
The Stabilizing Mechanism of Immobilized Metagenomic Xylanases on Bio-Based Hydrogels to Improve Utilization Performance: Computational and Functional Perspectives	21
PEGylated Nanoscale Metal–Organic Frameworks for Targeted Cancer Imaging and Drug Delivery	21
Reactive Oxygen Species-Responsive Liposomes via Boronate-Caged Phosphatidylethanolamine	21
Affinity-Based Methods for Site-Specific Conjugation of Antibodies	21
In Vivo Pretargeting Based on Cysteine-Selective Antibody Modification with IEDDA Bioorthogonal Handles for Click Chemistry	21
Chemo-Mechanical Modulation of Cell Motions Using DNA Nanosprings	20
Optimizing an Antioxidant TEMPO Copolymer for Reactive Oxygen Species Scavenging and Anti-Inflammatory Effects in Vivo	20
PET Imaging of Small Extracellular Vesicles via [⁸⁹Zr]Zr(oxinate)₄ Direct Radiolabeling	20
Chemiluminescence Detection of Hydrogen Sulfide Release by β-Lactamase-Catalyzed β-Lactam Biodegradation: Unprecedented Pathway for Monitoring β-Lactam Antibiotic Bacterial Resistance	20
Sortase-Mediated Quantifiable Enzyme Immobilization on Magnetic Nanoparticles	20
Developing PEGylated Reversed D-Peptide as a Novel HER2-Targeted SPECT Imaging Probe for Breast Cancer Detection	19
Dual Site-Specific Chemoenzymatic Antibody Fragment Conjugation Using CRISPR-Based Hybridoma Engineering	19
Homologous Structural, Chemical, and Biological Behavior of Sc and Lu Complexes of the Picaga Bifunctional Chelator: Toward Development of Matched Theranostic Pairs for Radiopharmaceutical Application	19

Enzyme-Agnostic Lysosomal Screen Identifies New Legumain-Cleavable ADC Linkers	19
Doxorubicin-Loaded Walnut-Shaped Polydopamine Nanomotor for Photothermal-Chemotherapy of Cancer	19
Ongoing Clinical Trials of Nonviral siRNA Therapeutics	19
Facile Synthesis of Amphiphilic Fluorescent Phosphorus Dendron-Based Micelles as Antiproliferative Agents: First Investigations	19
Squaric Acid-Based Radiopharmaceuticals for Tumor Imaging and Therapy	19
Developing GLP-1 Conjugated Self-Assembling Nanofibers Using Copper-Catalyzed Alkyne–Azide Cycloaddition and Evaluation of Their Biological Activity	19
Bivalent Conjugate Vaccine Induces Dual Immunogenic Response That Attenuates Heroin and Fentanyl Effects in Mice	18
One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody–Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling	18
Pioneering Iodine-125-Labeled Nanoscale Covalent Organic Frameworks for Brachytherapy	18
Triaging of DNA-Encoded Library Selection Results by High-Throughput Resynthesis of DNA–Conjugate and Affinity Selection Mass Spectrometry	18
Multifunctional Nanozyme Hydrogel with Mucosal Healing Activity for Single-Dose Ulcerative Colitis Therapy	18
Strategies to Control or Mimic Growth Factor Activity for Bone, Cartilage, and Osteochondral Tissue Engineering	18
Silk Sericin-Polylactide Protein–Polymer Conjugates as Biodegradable Amphiphilic Materials and Their Application in Drug Release Systems	17
Multifunctional Transferrin Encapsulated GdF₃ Nanoparticles for Sentinel Lymph Node and Tumor Imaging	17
Exo-Enzymatic Cell-Surface Glycan Labeling for Capturing Glycan–Protein Interactions through Photo-Cross-Linking	17
Nongenetic Bioconjugation Strategies for Modifying Cell Membranes and Membrane Proteins: A Review	17
Nanotargeting of Resistant Infections with a Special Emphasis on the Biofilm Landscape	17
Recent Progress in Bile Acid-Based Antimicrobials	17
Reduction-Sensitive Dextran–Paclitaxel Polymer–Drug Conjugate: Synthesis, Self-Assembly into Nanoparticles, and In Vitro Anticancer Efficacy	17
An Apoferritin–Hemagglutinin Conjugate Vaccine with Encapsulated Nucleoprotein Antigen Peptide from Influenza Virus Confers Enhanced Cross Protection	17
The Protein Corona Conundrum: Exploring the Advantages and Drawbacks of its Presence around Amphiphilic Nanoparticles	16
H₂BZmacropa-NCS: A Bifunctional Chelator for Actinium-225 Targeted Alpha Therapy	16
Cyclic Anhydrides as Powerful Tools for Bioconjugation and Smart Delivery	16
Investigational Therapies for Primary Hyperoxaluria	16
Cyclotriphosphazene-Based “Butterfly” Fluorescence Probe for Lysosome Targeting	16
Site-Specific Conjugation Strategy for Dual Antibody–Drug Conjugates Using Aerobic Formylglycine-Generating Enzymes	16
Design, Synthesis, and Evaluation of Trivalent PROTACs Having a Functionalization Site with Controlled Orientation	16
Internal Oligoguanidinium Transporter: Mercury-Free Scalable Synthesis, Improvement of Cellular Localization, Endosomal Escape, Mitochondrial Localization, and Conjugation with Antisense Morpholino fo	16
Highly Photoluminescent Nitrogen- and Zinc-Doped Carbon Dots for Efficient Delivery of CRISPR/Cas9 and mRNA	16
Targeted In Vivo Loading of Red Blood Cells Markedly Prolongs Nanocarrier Circulation	15
Protein Conjugation by Electrophilic Alkynylation Using 5-(Alkynyl)dibenzothiophenium Triflates	15
[⁶⁸Ga]Ga-THP-Pam: A Bisphosphonate PET Tracer with Facile Radiolabeling and Broad Calcium Mineral Affinity	15
One-Pot Synthesis of Defined-Length ssDNA for Multiscaffold DNA Origami	15
Coelenterazine Analogue with Human Serum Albumin-Specific Bioluminescence	15
The Influence of a Polyethylene Glycol Linker on the Metabolism and Pharmacokinetics of a ⁸⁹Zr-Radiolabeled Antibody	15
Combinatorial Library of Cyclic Benzylidene Acetal-Containing pH-Responsive Lipidoid Nanoparticles for Intracellular mRNA Delivery	15
Label-Free, Multiplex Glycan Microarray Biosensor for Influenza Virus Detection	15
Dual Blood–Brain Barrier–Glioma Targeting Peptide–Poly(levodopamine) Hybrid Nanoplatforms as Potential Near Infrared Phototheranostic Agents in Glioblastoma	15
Dendrimer-Based Nanogels for Cancer Nanomedicine Applications	14
Pam₃CSK₄-CDG^SF Augments Antitumor Immunotherapy by Synergistically Activating TLR1/2 and STING	14
Molecular Dynamics-Guided Design of a Functional Protein–ATRP Conjugate That Eliminates Protein–Protein Interactions	14
Chemoselective Methionine Bioconjugation: Site-Selective Fluorine-18 Labeling of Proteins and Peptides	14
3D-Printing Biodegradable PU/PAAM/Gel Hydrogel Scaffold with High Flexibility and Self-Adaptibility to Irregular Defects for Nonload-Bearing Bone Regeneration	14
Generation of Multivalent Nanobody-Based Proteins with Improved Neutralization of Long α-Neurotoxins from Elapid Snakes	14
Cyclodextrin/Adamantane-Mediated Targeting of Inoculated Bacteria in Mice	14
Structure–Activity Relationships of Antibody-Drug Conjugates: A Systematic Review of Chemistry on the Trastuzumab Scaffold	14
Zwitterionic Polymer Conjugated Glucagon-like Peptide-1 for Prolonged Glycemic Control	14
Condensation of DNA-Conjugated Imines with Homophthalic Anhydride for the Synthesis of Isoquinolones on DNA	14
Design and Synthesis of Piperazine-Based Compounds Conjugated to Humanized Ferritin as Delivery System of siRNA in Cancer Cells	14
Ratiometric Fluorescent Biosensor Based on Self-Assembled Fluorescent Gold Nanoparticles and Duplex-Specific Nuclease-Assisted Signal Amplification for Sensitive Detection of Exosomal miRNA	14
NIR Fluorescent Imaging and Photodynamic Therapy with a Novel Theranostic Phospholipid Probe for Triple-Negative Breast Cancer Cells	14
DiPODS: A Reagent for Site-Specific Bioconjugation via the Irreversible Rebridging of Disulfide Linkages	14
Ultrasound-Augmented Phase Transition Nanobubbles for Targeted Treatment of Paclitaxel-Resistant Cancer	14
Targeted Delivery of Cabazitaxel Using Cyclic Cell-Penetrating Peptide and Biomarkers of Extracellular Matrix for Prostate and Breast Cancer Therapy	14
Design and Synthesis of Cathepsin-K-Activated Osteoadsorptive Fluorogenic Sentinel (OFS) Probes for Detecting Early Osteoclastic Bone Resorption in a Multiple Myeloma Mouse Model	13
Stable and Highly Efficient Antibody–Nanoparticles Conjugation	13
Hypoxia-Activated Prodrug Enabling Synchronous Chemotherapy and HIF-1α Downregulation for Tumor Treatment	13
Identification of a DNA Aptamer That Binds to Human Monocytes and Macrophages	13
Gold Nanoparticles as Carriers for Functional RNA Nanostructures	13
A NIR Aggregation-Induced Emission Fluoroamphiphile as Visually Trackable and Serum-Tolerant Nonviral Gene Carrier	13
Tailored Linker Chemistries for the Efficient and Selective Activation of ADCs with KSPi Payloads	13
Innovative Bioconjugation Technology for Antibody–Drug Conjugates: Proof of Concept in a CD30-Positive Lymphoma Mouse Model	13
NIR II Luminescence Imaging for Sentinel Lymph Node and Enhanced Chemo-/Photothermal Therapy for Breast Cancer	13
Theranostic Activity of Nitric Oxide-Releasing Carbon Quantum Dots	13
A Novel NAMPT Inhibitor-Based Antibody–Drug Conjugate Payload Class for Cancer Therapy	13
Discovery of Bivalent GalNAc-Conjugated Betulin as a Potent ASGPR-Directed Agent against Hepatocellular Carcinoma	13
Expanding the Scope of Ugi Multicomponent Bioconjugation to Produce Pneumococcal Multivalent Glycoconjugates as Vaccine Candidates	13
Solid-Phase Assembly of Multienzyme Systems into Artificial Cellulosomes	13
Folic Acid-Functionalized Nanomedicine: Folic Acid Conjugated Copolymer and Folate Receptor Interactions Disrupt Receptor Functionality Resulting in Dual Therapeutic Anti-Cancer Potential in Breast an	13
Development of Red-Emissive Carbon Dots for Bioimaging through a Building Block Approach: Fundamental and Applied Studies	13
Effects of Glycosylation and d-Amino Acid Substitution on the Antitumor and Antibacterial Activities of Bee Venom Peptide HYL	13
Supramolecular Dipeptide-Based Near-Infrared Fluorescent Nanotubes for Cellular Mitochondria Targeted Imaging and Early Apoptosis	13
Acoustically Detonated Microbubbles Coupled with Low Frequency Insonation: Multiparameter Evaluation of Low Energy Mechanical Ablation	13
Renal Handling of ^99mTc-Labeled Antibody Fab Fragments with a Linkage Cleavable by Enzymes on Brush Border Membrane	13
AIE-Based Dynamic in Situ Nanoscale Visualization of Amyloid Fibrillation from Hen Egg White Lysozyme	13
Designed Streptococcus pyogenes Sortase A Accepts Branched Amines as Nucleophiles in Sortagging	13
Combining Doxorubicin-Conjugated Polymeric Nanoparticles and 5-Aminolevulinic Acid for Enhancing Radiotherapy against Lung Cancer	13
Efficient Labeling of Native Human IgG by Proximity-Based Sortase-Mediated Isopeptide Ligation	13
Genetic Code Expansion Enables Site-Specific PEGylation of a Human Growth Hormone Receptor Antagonist through Click Chemistry	13
ImmunoPET of CD146 in Orthotopic and Metastatic Breast Cancer Models	13

Resveratrol Carbon Dots Disrupt Mitochondrial Function in Cancer Cells	13
Tailored Bioorthogonal and Bioconjugate Chemistry: A Source of Inspiration for Developing Kinetic Target-Guided Synthesis Strategies	13
Synthesis and Shaping of Core–Shell Tecto Dendrimers for Biomedical Applications	12
Silicon-Containing Neurotensin Analogues as Radiopharmaceuticals for NTS₁-Positive Tumors Imaging	12
Nucleic Acid Conformation Influences Postsynthetic Suzuki–Miyaura Labeling of Oligonucleotides	12
Generation and Biological Evaluation of Fc Antigen Binding Fragment-Drug Conjugates as a Novel Antibody-Based Format for Targeted Drug Delivery	12
Designing Functional Bionanoconstructs for Effective In Vivo Targeting	12
Carborane as an Alternative Efficient Hydrophobic Tag for Protein Degradation	12
“Clickable” Polymer Brush Interfaces: Tailoring Monovalent to Multivalent Ligand Display for Protein Immobilization and Sensing	12
Fluorescent Peptide Dendrimers for siRNA Transfection: Tracking pH Responsive Aggregation, siRNA Binding, and Cell Penetration	12
Recent Progress of Surface Modified Nanomaterials for Scavenging Reactive Oxygen Species in Organism	12
Development of [¹⁸F]AmBF₃ Tetrazine for Radiolabeling of Peptides: Preclinical Evaluation and PET Imaging of [¹⁸F]AmBF₃-PEG₇-Tyr³-Octr	12
Enhancing Combined Immunotherapy and Radiotherapy through Nanomedicine	12
Benzylguanidine and Galactose Double-Conjugated Chitosan Nanoparticles with Reduction Responsiveness for Targeted Delivery of Doxorubicin to CXCR 4 Positive Tumors	12
Influence of Riboflavin Targeting on Tumor Accumulation and Internalization of Peptostar Based Drug Delivery Systems	12
A Simple and Efficient Method to Generate Dual Site-Specific Conjugation ADCs with Cysteine Residue and an Unnatural Amino Acid	12
Impact of Ligand Size and Conjugation Chemistry on the Performance of Universal Chimeric Antigen Receptor T-Cells for Tumor Killing	12
Enabling Indium Channels for Mass Cytometry by Using Reinforced Cyclam-Based Chelating Polylysine	12
Large, Anionic Liposomes Enable Targeted Intraperitoneal Delivery of a TLR 7/8 Agonist To Repolarize Ovarian Tumors’ Microenvironment	12
Site-Specific and Trigger-Activated Modification of Proteins by Means of Catalytic Hemin/G-quadruplex DNAzyme Nanostructures	12
Recent Advances in Bioorthogonal Click Chemistry for Enhanced PET and SPECT Radiochemistry	12
Chemo-Enzymatic PEGylation/POxylation of Murine Interleukin-4	12
EGFR Ligand Clustering on E2 Bionanoparticles for Targeted Delivery of Chemotherapeutics to Breast Cancer Cells	11
Complement Inhibitors Block Complement C3 Opsonization and Improve Targeting Selectivity of Nanoparticles in Blood	11
Biotinylated Streptavidin Surface Coating Improves the Efficacy of a PLGA Microparticle-Based Cancer Vaccine	11
The Role of Ultrasound in Modulating Interstitial Fluid Pressure in Solid Tumors for Improved Drug Delivery	11
Nanolipoprotein Particles as a Delivery Platform for Fab Based Therapeutics	11
Temporal Control of Efficient In Vivo Bioconjugation Using a Genetically Encoded Tetrazine-Mediated Inverse-Electron-Demand Diels–Alder Reaction	11
Facile Synthesis of a Redox-Responsive Hyperbranched Polymer Prodrug as a Unimolecular Micelle for the Tumor-Selective Drug Delivery	11
RXH-Reactive ¹⁸F-Vinyl Sulfones as Versatile Agents for PET Probe Construction	11
Enhancing the Carboxylation Efficiency of Silk Fibroin through the Disruption of Noncovalent Interactions	11
Dual Site-Selective Presentation of Functional Handles on Protein-Engineered Cowpea Chlorotic Mottle Virus-Like Particles	11
HaloTag Forms an Intramolecular Disulfide	11
Synthesis and Evaluation of New Trivalent Ligands for Hepatocyte Targeting via the Asialoglycoprotein Receptor	11
Nanopaper Biosensors at Point of Care	11
Biocompatible and Rapid Cyclization of Peptides with 2,4-Difluoro-6-hydroxy-1,3,5-benzenetricarbonitrile for the Development of Cyclic Peptide Libraries	11
Lighting Up the Thrombin-Binding Aptamer G-Quadruplex with an Internal Cyanine-Indole-Quinolinium Nucleobase Surrogate. Direct Fluorescent Intensity Readout for Thrombin Binding without Topology Switc	11
RGD-Modified Titanium as an Improved Osteoinductive Biomaterial for Use in Dental and Orthopedic Implants	11
Cyclic Thiosulfinates as a Novel Class of Disulfide Cleavable Cross-Linkers for Rapid Hydrogel Synthesis	11
DNA-Compatible Synthesis of α,β-Epoxyketones for DNA-Encoded Chemical Libraries	11
A Plug-and-Play Platform for the Formation of Trifunctional Cysteine Bioconjugates that also Offers Control over Thiol Cleavability	11
Multifunctional Neomycin-Triazine-Based Cationic Lipids for Gene Delivery with Antibacterial Properties	11
Conjugated Protein Domains as Engineered Scaffold Proteins	11
Site-Specific, Platform-Based Conjugation Strategy for the Synthesis of Dual-Labeled Immunoconjugates for Bimodal PET/NIRF Imaging of HER2-Positive Tumors	11
Exo-Enzymatic Addition of Diazirine-Modified Sialic Acid to Cell Surfaces Enables Photocrosslinking of Glycoproteins	11
Development of a Squaraine-Based Molecular Probe for Dual-Modal in Vivo Fluorescence and Photoacoustic Imaging	11
Flavin-Conjugated Nanobombs: Key Structural Requirements Governing Their Self-Assemblies’ Morphologies	10
Fluorescein and Rhodamine B-Binding Domains from Autodisplayed Fv-Antibody Library	10
Structural Investigations, Cellular Imaging, and Radiolabeling of Neutral, Polycationic, and Polyanionic Functional Metalloporphyrin Conjugates	10
Isotope-Coded Maleimide Affinity Tags for Proteomics Applications	10
Redox-Responsive Nanocapsules for the Spatiotemporal Release of Miltefosine in Lysosome: Protection against Leishmania	10
Blood-Brain Barrier Penetrating Luminescent Conjugates Based on Cyclometalated Platinum(II) Complexes	10
Bioinspired Fabrication of Calcium-Doped TiP Coating with Nanofibrous Microstructure to Accelerate Osseointegration	10
Portfolio Targeting Strategy To Realize the Assembly and Membrane Fusion-Mediated Delivery of Gold Nanoparticles to Mitochondria for Enhanced NIR Photothermal Therapies	10
Dexamethasone and Fumaric Acid Ester Conjugate Synergistically Inhibits Inflammation and NF-κB in Macrophages	10
Piggybacking on the Cholera Toxin: Identification of a CTB-Binding Protein as an Approach for Targeted Delivery of Proteins to Motor Neurons	10
Development of a Versatile and Modular Linker for Antibody–Drug Conjugates Based on Oligonucleotide Strand Pairing	10
Gemcitabine Lipid Prodrugs: The Key Role of the Lipid Moiety on the Self-Assembly into Nanoparticles	10
An Integrated Tumor Microenvironment Responsive Polymeric Micelle for Smart Drug Delivery and Effective Drug Release	10
Ultrasonic-Assisted Solid-Phase Peptide Synthesis of DOTA-TATE and DOTA-linker-TATE Derivatives as a Simple and Low-Cost Method for the Facile Synthesis of Chelator–Peptide Conjugates	10
Thiol-Reactive Clickable Cryogels: Importance of Macroporosity and Linkers on Biomolecular Immobilization	10
Directly Quantifiable Biotinylation Using a Water-Soluble Isatoic Anhydride Platform	10
Optimization of Enzymolysis Clearance Strategy To Enhance Renal Clearance of Radioligands	10
IgG-Binding Nanobody Capable of Prolonging Nanobody-Based Radiotracer Plasma Half-Life and Enhancing the Efficacy of Tumor-Targeted Radionuclide Therapy	10
Engineering PEGylated Polyester Nanoparticles to Reduce Complement-Mediated Infusion Reaction	10
FRET-Based Method for Direct, Real-Time Measurement of DNA Methyltransferase Activity	10
Strain-Promoted Azide–Alkyne Cycloaddition-Based PSMA-Targeting Ligands for Multimodal Intraoperative Tumor Detection of Prostate Cancer	10
Precise Installation of Diazo-Tagged Side-Chains on Proteins to Enable In Vitro and In-Cell Site-Specific Labeling	10
Epigenetic Platinum Complexes Breaking the “Eat Me/Don’t Eat Me” Balance for Enhanced Cancer Chemoimmunotherapy	10
DNA Compatible Oxidization and Amidation of Terminal Alkynes	10
Amino BODIPY-Based Blue Fluorescent Probes for Aldehyde Dehydrogenase 1-Expressing Cells	10
Non-Genetic Generation of Antibody Conjugates Based on Chemoenzymatic Tyrosine Click Chemistry	10
Synthesis and Evaluation of Ubiquitin–Dioxetane Conjugate as a Chemiluminescent Probe for Monitoring Deubiquitinase Activity	9
Synthesis and Evaluation of Three Azide-Modified Disaccharide Oxazolines as Enzyme Substrates for Single-Step Fc Glycan-Mediated Antibody-Drug Conjugation	9
²¹¹At-Labeled Polymer Nanoparticles for Targeted Radionuclide Therapy of Glucose-Dependent Insulinotropic Polypeptide Receptor (GIPR)-Overexpressed Cancer	9
Attenuation of the Reaction of Michael Acceptors with Biologically Important Nucleophiles	9
Effect of PEGylation on Host Defense Peptide Complexation with Bacterial Lipopolysaccharide	9
Potentiating the Membrane Interaction of an Attenuated Cationic Amphiphilic Lytic Peptide for Intracellular Protein Delivery by Anchoring with Pyrene Moiety	9
Fast and Selective Reaction of 2-Benzylacrylaldehyde with 1,2-Aminothiol for Stable N-Terminal Cysteine Modification and Peptide Cyclization	9
An Artificial Amphiphilic Peptide Promotes Endocytic Uptake by Inducing Membrane Curvature	9
Simultaneous Targeting of Two Master Regulators of Apoptosis with Dual-Action PNA– and DNA–Peptide Conjugates	9
Enhancing Cancer Immunotherapeutic Efficacy with Sonotheranostic Strategies	9
Tetrazine-TCO Ligation: A Potential Simple Approach to Improve Tumor Uptake through Enhanced Blood Circulation	9
Ratiometric Fluorescence Monitoring of Antibody-Guided Drug Delivery to Cancer Cells	9
MMP-2-Activatable Photoacoustic Tumor Imaging Probes Based on Al- and Si-Naphthalocyanines	9
Cucurbituril–Ferrocene: Host–Guest Based Pretargeted Positron Emission Tomography in a Xenograft Model	9
Copper-Free Click Enabled Triazabutadiene for Bioorthogonal Protein Functionalization	9
Antibody-Mediated Screening of Peptide Inhibitors for Monoamine Oxidase-B (MAO-B) from an Autodisplayed F_V Library	9
Rapid, High-Yielding Solid-Phase Synthesis of Cathepsin-B Cleavable Linkers for Targeted Cancer Therapeutics	9
Liver Phosphoenolpyruvate Carboxykinase-1 Downregulation via siRNA-Functionalized Graphene Oxide Nanosheets Restores Glucose Homeostasis in a Type 2 Diabetes Mellitus In Vivo Model	9
Kinetics and Optimization of the Lysine–Isopeptide Bond Forming Sortase Enzyme from Corynebacterium diphtheriae	9
Design of Neuraminidase-Targeted Imaging and Therapeutic Agents for the Diagnosis and Treatment of Influenza Virus Infections	9
Artificial Nanocage Formed via Self-Assembly of β-Annulus Peptide for Delivering Biofunctional Proteins into Cell Interiors	9
Using Spectroscopy to Guide the Adaptation of Aptamers into Electrochemical Aptamer-Based Sensors	9
Large-Scale 3D Optical Mapping and Quantitative Analysis of Nanoparticle Distribution in Tumor Vascular Microenvironment	9