OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacological Research is 75. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	299
Gut-vascular axis and postbiotics: The need for clear definitions and further research	271
An account on the history of pharmacology in Spain	264
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	234
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	216
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	206
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	180
Time-dependent proteomics and drug response in expanding cancer cells	180
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	157
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	156
Progress in the development of modulators targeting Frizzleds	155
Paeoniflorin as a potential therapeutic agent for cerebrovascular diseases: A comprehensive review	147
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	147
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	146
Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD	142
Astaxanthin: A promising therapeutic agent for organ fibrosis	142
Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study	140
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	139
Editorial Board	137
Rapid 64Cu radiolabeling and in vivo evaluation of DSPE–NODAGA liposomes in a murine mammary tumor model	134
Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation	127
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	124
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	121
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	120
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	119

Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	116
Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective	115
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	115
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	114
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	114
Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	114
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	112
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	112
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	111
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	110
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	109
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	108
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	107
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	105
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	104
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	102
Targeting regulated cell death in aortic aneurysm and dissection therapy	98
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	95
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	94
Protective effect and mechanisms of puerarin in metabolic dysfunction-associated steatotic liver disease: A systematic review and meta-analysis of animal studies	94
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	93
Spatial proteomic profiling reveals conserved prognostic immune microenvironment features across molecular subtypes in small cell lung cancer	93
Discovery, development, and characterization of potent and selective USP11 inhibitors	92
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	91
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	89
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	89
Sex differences in the weight response to GLP-1RA in people with type 2 diabetes. A long-term longitudinal real-world study	89
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	88
Decoding the Metabolic-immune Axis: Neutrophil glycolysis-driven tumor niche remodeling and its therapeutic exploitation	87
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	86
Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora	85
Polypharmacology: The science of multi-targeting molecules	84
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	84
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	84
Corrigendum to ‘Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein’ [Pharmacol. Res. 175 (2022) 105975]	83
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	83
Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence	81
Sailing south from regulations to strategies: Macau as a promising gateway for the export of proprietary Chinese medicines to ASEAN countries	79
Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the "Evolutionary Traps"	78
Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease	78
Profiling the impact of anti-human CD20 monoclonal antibodies on lymphocyte B cell subsets and their precursors in the bone marrow and in lymphoid tissues in an immunocompromised mouse engrafted with	78
Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease	77
Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets	77
Editorial Board	77
Corrigendum to “Deficiency in adiponectin exaggerates cigarette smoking exposure-induced cardiac contractile dysfunction: Role of autophagy” [Pharm. Res. 100 (2015) 175–89]	76
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	76
Net clinical benefit of a reduced dose of DOACs in non-valvular atrial fibrillation: A meta-analysis of randomized trials	76
Combining choline bitartrate and vitamin B12 ameliorates cognitive impairment in hypertensive elders with cognitive frailty	76
Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient as	75
Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE-/- mice corpus cavernosum microcirculation	75

Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression