Pharmacological Research

Papers
(The H4-Index of Pharmacological Research is 70. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models448
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020415
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer200
Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions196
Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization196
A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol179
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis175
Promising LOX proteins for cartilage-targeting osteoarthritis therapy162
Substance use disorders and cooperative research on addictions: Spanish approach as a model159
New therapeutic approaches in children’s medicine towards solving critical issues in pediatrics159
NLRP3 inflammasome links vascular senescence to diabetic vascular lesions154
From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases152
Quality and composition control of complex TCM preparations through a novel “Herbs-in vivo Compounds-Targets-Pathways” network methodology: The case of Lianhuaqingwen capsules150
Reply to the letter comment of Su Boon Yong MD, PhD and colleagues to: Improved glycemic and weight control with Dulaglutide addition in SGLT2 inhibitor treated obese type 2 diabetic patients at high 145
IUPHAR review: Eating disorders, gut microbiota dysbiosis and epigenetic aberrations142
PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psoriasis141
Suppression of macrophage migration by down-regulating Src/FAK/P130Cas activation contributed to the anti-inflammatory activity of sinomenine138
Kallikrein inhibitor derived from immunoglobulin heavy chain junction region possesses anti-thromboinflammation potential137
New insights into the role and therapeutic potential of HSP70 in diabetes136
Chios mastiha essential oil exhibits antihypertensive, hypolipidemic and anti-obesity effects in metabolically unhealthy adults - a randomized controlled trial130
Bufalin for an innovative therapeutic approach against cancer129
Pharmacological regression of atherosclerotic plaque in patients with type 2 diabetes125
Bioactive compounds in childhood obesity and associated metabolic complications: Current evidence, controversies and perspectives123
Targeting cellular senescence in cancer by plant secondary metabolites: A systematic review121
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression117
Effects of SGLT2 inhibition via empagliflozin on cognitive and physical impairment in frail diabetic elders with chronic kidney disease117
Lycorine suppresses the malignancy of breast carcinoma by modulating epithelial mesenchymal transition and β-catenin signaling115
SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies112
Improving the tumor selectivity of T cell engagers by logic-gated dual tumor-targeting112
Editorial Board107
Editorial Board107
Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?106
Editorial Board103
Comment: Polymorphisms indicating risk of inflammatory bowel disease or antigenicity to anti-TNF drugs as biomarkers of response in children98
Editorial Board97
The novel role of glucocorticoid-induced leucine zipper as a marker of mucosal healing in inflammatory bowel diseases96
Response to the comment on "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies"96
Vitamin D supplementation: an adjunct therapy for improving inflammatory and oxidative stress?95
Exploring the pharmacological versatility of ficus carica: Modulating classical immunometabolism and beyond95
Editorial Board95
Treating COVID-19 with NRICM101 and NRICM102 – Author’s reply 294
Comparative efficacy and rankings of therapeutics for ALK-positive non-small cell lung cancer with brain metastasis: Updated results from a Bayesian network analysis based on randomized controlled tri93
Enhanced efficacy of formoterol-montelukast salt in relieving asthma features and in preserving β2-agonists rescue therapy93
Development status and prospects of international standardization of medical devices of Traditional Chinese Medicine92
Editorial Board92
Response to the comment “Is SGLT2i superior to DPP4i for primary and secondary prevention of cardiovascular diseases and death in patients with type 2 diabetes?”86
Features and development trends in international standardization of Chinese materia medica in ISO/TC 24986
Key factors influencing the TCM nomenclature in international standards86
Editorial Board84
Editorial Board83
Astaxanthin: A promising therapeutic agent for organ fibrosis82
Mesenchymal stem cells plus bone repair materials as a therapeutic strategy for abnormal bone metabolism: Evidence of clinical efficacy and mechanisms of action implied82
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation82
Evidence of a dual mechanism of action underlying the anti-proliferative and cytotoxic effects of ammonium-alkyloxy-stilbene-based α7- and α9-nicotinic ligands on glioblastoma cells80
Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis80
Efficacy and safety of liraglutide in type 2 diabetes mellitus patients complicated with coronary artery disease: A systematic review and meta-analysis of randomized controlled trials79
Comparative effects of nutraceuticals on body weight in adults with overweight or obesity: A systematic review and network meta-analysis of 111 randomized clinical trials77
Animal models to study pathogenesis and treatments of cardiac disorders in rheumatoid arthritis: Advances and challenges for clinical translation77
Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathy76
Counteracting health risks by Modulating Homeostatic Signaling76
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?76
Bedaquiline and Linezolid improve anti-TB treatment outcome in drug-resistant TB patients with HIV: A systematic review and meta-analysis75
Downregulation of the farnesoid X receptor promotes colorectal tumorigenesis by facilitating enterotoxigenic Bacteroides fragilis colonization74
Editorial Board74
PCSK9 inhibition and broad health outcomes: A Mendelian randomization phenome‑wide association study74
Biomimetic micelles to accurately regulate the inflammatory microenvironment for glomerulonephritis treatment74
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway73
CERS4 predicts positive anti-PD-1 response and promotes immunomodulation through Rhob-mediated suppression of CD8+Tim3+ exhausted T cells in non-small cell lung cancer71
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease71
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein70
The VEGFs/VEGFRs system in Alzheimer’s and Parkinson’s diseases: Pathophysiological roles and therapeutic implications70
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