OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacological Research is 73. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	521
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	494
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	246
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	244
An account on the history of pharmacology in Spain	211
Gut-vascular axis and postbiotics: The need for clear definitions and further research	207
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	198
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	186
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	185
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	179
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	175
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	174
Time-dependent proteomics and drug response in expanding cancer cells	162
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	161
Looking deeper into the findings of DARE-19: Failure or an open door to future success?	154
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	149
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	148
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	144
Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications	143
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	141
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	140
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	134
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	134
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	130
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	129

Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcoma	129
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	124
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	117
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	116
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	116
Targeting regulated cell death in aortic aneurysm and dissection therapy	113
Polypharmacology: The science of multi-targeting molecules	112
Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD	108
Komagataella pastoris KM71H modulates neuroimmune and oxidative stress parameters in animal models of depression: A proposal for a new probiotic with antidepressant-like effect	107
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	104
Progress in the development of modulators targeting Frizzleds	100
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease	99
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	99
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	98
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	98
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	98
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	97
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	97
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	96
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	93
Decoding the Metabolic-immune Axis: Neutrophil glycolysis-driven tumor niche remodeling and its therapeutic exploitation	93
Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora	92
Editorial Board	92
Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	90
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities	89
Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective	88
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	85
Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism	85
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	83
Astaxanthin: A promising therapeutic agent for organ fibrosis	83
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	83
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	82
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	82
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	82
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	81
Corrigendum to ‘Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein’ [Pharmacol. Res. 175 (2022) 105975]	81
Editorial Board	80
Naphthoquinone derivatives as P-glycoprotein inducers in inflammatory bowel disease: 2D monolayers, 3D spheroids, and in vivo models	78
Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression	78
Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis	77
The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition	77
Dihydroartemisinin overcomes the resistance to osimertinib in EGFR-mutant non-small-cell lung cancer	77
Functional metabolomics revealed the dual-activation of cAMP-AMP axis is a novel therapeutic target of pancreatic cancer	76
The major histocompatibility complex participates in Parkinson’s disease	74
Recent advances in glioma microenvironment-response nanoplatforms for phototherapy and sonotherapy	73
Ferritin nanoconjugates guide trastuzumab brain delivery to promote an antitumor response in murine HER2 + breast cancer brain metastasis	73
Atrial fibrillation: Epigenetic aspects and role of sodium-glucose cotransporter 2 inhibitors	73
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain	73