OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacological Research is 73. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	542
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	514
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	259
An account on the history of pharmacology in Spain	258
Gut-vascular axis and postbiotics: The need for clear definitions and further research	222
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	214
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	203
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	189
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	189
Time-dependent proteomics and drug response in expanding cancer cells	181
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	175
Looking deeper into the findings of DARE-19: Failure or an open door to future success?	165
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	162
Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcoma	156
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	151
Targeting regulated cell death in aortic aneurysm and dissection therapy	147
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	142
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	140
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	140
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	138
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	136
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	135
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities	124
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	122
Komagataella pastoris KM71H modulates neuroimmune and oxidative stress parameters in animal models of depression: A proposal for a new probiotic with antidepressant-like effect	122

Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	120
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	119
Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD	116
Decoding the Metabolic-immune Axis: Neutrophil glycolysis-driven tumor niche remodeling and its therapeutic exploitation	114
Editorial Board	113
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	111
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	111
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	105
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	103
Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective	103
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	102
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	102
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	100
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	100
Progress in the development of modulators targeting Frizzleds	99
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	96
Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora	96
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	96
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	94
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	93
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	93
Astaxanthin: A promising therapeutic agent for organ fibrosis	93
Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study	89
Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation	88
Sex differences in the weight response to GLP-1RA in people with type 2 diabetes. A long-term longitudinal real-world study	88
Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism	87
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	86
Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	86
Polypharmacology: The science of multi-targeting molecules	85
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	85
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	85
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	85
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease	82
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	82
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	82
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	80
Corrigendum to ‘Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein’ [Pharmacol. Res. 175 (2022) 105975]	79
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	78
Editorial Board	77
Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression	75
The major histocompatibility complex participates in Parkinson’s disease	75
Naphthoquinone derivatives as P-glycoprotein inducers in inflammatory bowel disease: 2D monolayers, 3D spheroids, and in vivo models	75
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain	75
Atrial fibrillation: Epigenetic aspects and role of sodium-glucose cotransporter 2 inhibitors	74
Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis	74
Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease	74
Functional metabolomics revealed the dual-activation of cAMP-AMP axis is a novel therapeutic target of pancreatic cancer	73
Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease	73
α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation	73