OOIR: Observatory of International Research

Papers

(The H4-Index of Pharmacological Research is 71. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Editorial Board	478
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	451
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	226
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	216
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	206
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	190
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	178
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	175
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	174
An account on the history of pharmacology in Spain	168
Gut-vascular axis and postbiotics: The need for clear definitions and further research	167
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	166
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities	160
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	156
In vitro angiogenesis inhibition with selective compounds targeting the key glycolytic enzyme PFKFB3	154
Looking deeper into the findings of DARE-19: Failure or an open door to future success?	145
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	140
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	138
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	136
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	135
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	134
Progress in the development of modulators targeting Frizzleds	126
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	124
Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcoma	122
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	121

Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	121
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	118
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	117
Komagataella pastoris KM71H modulates neuroimmune and oxidative stress parameters in animal models of depression: A proposal for a new probiotic with antidepressant-like effect	111
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	108
The effect of tibolone treatment on lipid profile in women: A systematic review and dose-response meta-analysis of randomized controlled trials	107
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	106
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease	104
Time-dependent proteomics and drug response in expanding cancer cells	103
Astaxanthin: A promising therapeutic agent for organ fibrosis	100
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	100
Targeting regulated cell death in aortic aneurysm and dissection therapy	98
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	94
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	93
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	93
Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	91
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	90
Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective	90
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	89
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	89
Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora	89
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	88
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	87
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	86
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	85
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	82
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	81
Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism	80
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	79
Polypharmacology: The science of multi-targeting molecules	78
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	78
Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease	77
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	77
Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications	77
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	77
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	76
The potential modulatory role of curcumin on renal epithelial-to-mesenchymal transition in renal diseases	76
Corrigendum to ‘Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein’ [Pharmacol. Res. 175 (2022) 105975]	76
Editorial Board	76
Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy	75
Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma	75
Regulation of nicotinic acetylcholine receptors by post-translational modifications	75
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain	74
Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression	72
Combining liquid biopsy and radiomics for personalized treatment of lung cancer patients. State of the art and new perspectives	72
DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: A meta-analysis and systematic review	71
A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine	71