Pharmacological Research

Article	Citations
Editorial Board	498
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	474
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	241
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	232
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	208
An account on the history of pharmacology in Spain	193
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	193
Gut-vascular axis and postbiotics: The need for clear definitions and further research	179
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	174
Polypharmacology: The science of multi-targeting molecules	172
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	170
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	169
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	161
Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective	157
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	151
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities	142
Editorial Board	140
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	140
Decoding the Metabolic-immune Axis: Neutrophil glycolysis-driven tumor niche remodeling and its therapeutic exploitation	139
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	138
Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	134
Noncoding RNAs involved in DNA methylation and histone methylation, and acetylation in diabetic vascular complications	129
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	127
Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism	123
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	123

The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	119
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	114
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	113
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	113
Time-dependent proteomics and drug response in expanding cancer cells	109
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	108
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	106
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	104
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	103
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	98
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	97
Looking deeper into the findings of DARE-19: Failure or an open door to future success?	95
The effect of tibolone treatment on lipid profile in women: A systematic review and dose-response meta-analysis of randomized controlled trials	94
Unraveling the roles of miRNAs in regulating epithelial-to-mesenchymal transition (EMT) in osteosarcoma	94
Komagataella pastoris KM71H modulates neuroimmune and oxidative stress parameters in animal models of depression: A proposal for a new probiotic with antidepressant-like effect	94
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	94
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	93
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	93
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	92
Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora	91
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	90
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	90
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	89
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	86
Progress in the development of modulators targeting Frizzleds	86
Targeting regulated cell death in aortic aneurysm and dissection therapy	83
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease	83
Astaxanthin: A promising therapeutic agent for organ fibrosis	83
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	82
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	82
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	81
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	80
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	80
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	80
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	80
Corrigendum to ‘Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein’ [Pharmacol. Res. 175 (2022) 105975]	79
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	79
Editorial Board	77
Regulation of nicotinic acetylcholine receptors by post-translational modifications	77
Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression	76
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain	76
Combining liquid biopsy and radiomics for personalized treatment of lung cancer patients. State of the art and new perspectives	76
A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine	75
Naphthoquinone derivatives as P-glycoprotein inducers in inflammatory bowel disease: 2D monolayers, 3D spheroids, and in vivo models	74
Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the "Evolutionary Traps"	73
A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating mφ polarization in TME	73
The potential modulatory role of curcumin on renal epithelial-to-mesenchymal transition in renal diseases	72
Sailing south from regulations to strategies: Macau as a promising gateway for the export of proprietary Chinese medicines to ASEAN countries	72
Dihydroartemisinin overcomes the resistance to osimertinib in EGFR-mutant non-small-cell lung cancer	72
Profiling the impact of anti-human CD20 monoclonal antibodies on lymphocyte B cell subsets and their precursors in the bone marrow and in lymphoid tissues in an immunocompromised mouse engrafted with	71

Corrigendum to “Deficiency in adiponectin exaggerates cigarette smoking exposure-induced cardiac contractile dysfunction: Role of autophagy” [Pharm. Res. 100 (2015) 175–89]	71
Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence	71
Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease	71
Medical treatment of weight loss in children and adolescents with obesity	70
Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice	70
α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation	70
Atrial fibrillation: Epigenetic aspects and role of sodium-glucose cotransporter 2 inhibitors	70
RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression	69
Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis	67
Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets	67
Targeting HDAC8 to ameliorate skeletal muscle differentiation in Duchenne muscular dystrophy	67
Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient as	67
Proneurogenic and neuroprotective effect of a multi strain probiotic mixture in a mouse model of acute inflammation: Involvement of the gut-brain axis	67
DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: A meta-analysis and systematic review	66
Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease	65
Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE-/- mice corpus cavernosum microcirculation	64
Net clinical benefit of a reduced dose of DOACs in non-valvular atrial fibrillation: A meta-analysis of randomized trials	64
The action of curcumin against damage resulting from cerebral stroke: A systematic review	64
ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites	64
Targeted and cytotoxic inhibitors used in the treatment of lung cancers	63
Nasal accumulation and metabolism of Δ9-tetrahydrocannabinol following aerosol (‘vaping’) administration in an adolescent rat model	63
TAK1 blockade as a therapy for retinal neovascularization	63
Protein-polysaccharide interactions for the fabrication of bioactive-loaded nanocarriers: Chemical conjugates and physical complexes	63
Recent advances in glioma microenvironment-response nanoplatforms for phototherapy and sonotherapy	63
Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in the pancreatic islet immune microenvironment in type 1 diabetes mellitus	63
Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK- mediated mitochondria protection in early diabetic retinopathy	63
Metabolic disorders affecting the liver and heart: Therapeutic efficacy of miRNA-based therapies?	63
Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges	62
Astrocytic connexin43 in the medial prefrontal cortex regulates depressive- and anxiety-like behaviors via ATP release	62
Cannabinoid-mediated targeting of mitochondria on the modulation of mitochondrial function and dynamics	62
The major histocompatibility complex participates in Parkinson’s disease	61
A copper nanocluster-based multifunctional nanoplatform for augmented chemo/chemodynamic/photodynamic combination therapy of breast cancer	60
Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review	60
The complementary and alternative roles of elemene injection in cancer: An umbrella review	60
Hormesis: Wound healing and keratinocytes	60
Ferritin nanoconjugates guide trastuzumab brain delivery to promote an antitumor response in murine HER2 + breast cancer brain metastasis	59
Pharmacological targeting of G protein-coupled receptor heteromers	59
Role of Angiopoietin-Tie axis in vascular and lymphatic systems and therapeutic interventions	59
Evaluation of the analgesic effect of ɑ-lipoic acid in treating pain disorders: A systematic review and meta-analysis of randomized controlled trials	59
The p53 pathway in vasculature revisited: A therapeutic target for pathological vascular remodeling?	58
Pharmacological targeting of microglia dynamics in Alzheimer’s disease: Preclinical and clinical evidence	58
Role of hypoxia in cellular senescence	58
The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition	58
Combining choline bitartrate and vitamin B12 ameliorates cognitive impairment in hypertensive elders with cognitive frailty	58
Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy	57
Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma	57
Remote ischemic conditioning attenuates blood-brain barrier disruption after recombinant tissue plasminogen activator treatment via reducing PDGF-CC	57
Functional metabolomics revealed the dual-activation of cAMP-AMP axis is a novel therapeutic target of pancreatic cancer	57
Commentary on “Apabetalone, a BET protein inhibitor, inhibits kidney damage in diabetes by preventing pyroptosis via modulating the P300/H3K27ac/PLK1 axis”	56
CircRNA in ocular neovascular diseases: Fundamental mechanism and clinical potential	56
Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials	56
Hormesis: wound healing and fibroblasts	56
IUPHAR editorial: Emerging targets for the treatment of pain: Moving towards non-addicting therapeutics and new preclinical directions	56
Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications	56
Role for the F-box proteins in heart diseases	55
Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression	55
Potential of diterpenes as antidiabetic agents: Evidence from clinical and pre-clinical studies	55
Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancer	55
Alternative splicing: A key regulator in T cell response and cancer immunotherapy	55
The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor	54
Systematic druggable genome-wide Mendelian randomization to identify therapeutic targets and dominant flora for ulcerative colitis	54
A panel of altered blood oxysterols in patients with mild cognitive impairment: A novel combined diagnostic marker	54
Targeting LRP6: A new strategy for cancer therapy	54
Corrigendum to “Ectopic expression of NKG7 enhances CAR-T function and improves the therapeutic efficacy in liquid and solid tumors” [Pharmacol. Res. 210 (2024) 107506]	53
Therapeutic induction of energy metabolism reduces neural tissue damage and increases microglia activation in severe spinal cord injury	53
MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis	53
Leveraging HER2-targeted biparatopic antibodies in solid tumors	52
Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through SESN2/AMPK/TSC2 pathway	52
New therapies towards a better glycemic control in youths with type 1 diabetes	52
Corrigendum to “A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating mφ polarization in TME” [Pharmacol. Res. 181 (2022) 106269]	52
Acute coronary syndrome and lipid-lowering therapy in a realistic diagnostic-therapeutic care pathway	52
Application of carbon monoxide in kidney and heart transplantation: A novel pharmacological strategy for a broader use of suboptimal renal and cardiac grafts	51
Establishment of an inducible cell line for Hepatitis B virus genotype C2 and its pharmacological responses to interferons	51
ER-organelle contacts: A signaling hub for neurological diseases	50
Editorial Board	50
Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming	50
Treating COVID-19 with NRICM101 and NRICM102 – Author’s reply 3	50
Special Issue Spanish Basic and Clinical Pharmacology	50
Multitarget ligands that comprise opioid/nonopioid pharmacophores for pain management: Current state of the science	49
Telmisartan induces a specific gut microbiota signature which may mediate its antiobesity effect	49

Editorial Board	49
Manuka honey activates the aryl hydrocarbon receptor: Implications for skin inflammation	49
Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice	49
Dapagliflozin acutely improves kidney function in type 2 diabetes mellitus. The PRECARE study	48
Mitochondria-targeted hydrogen sulfide donor reduces fatty liver and obesity in mice fed a high fat diet by inhibiting de novo lipogenesis and inflammation via mTOR/SREBP-1 and NF-κB signaling pathway	48
Functional significance of O-linked N-acetylglucosamine protein modification in regulating autophagy	48
Efficacy and safety of Qingda granule versus valsartan capsule in Chinese grade 1 hypertensive patients with low-moderate risk: A randomized, double-blind, double dummy, non-inferiority, multi-center	48
Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity	48
Kallistatin leads to cognition impairment via downregulating glutamine synthetase	48
Gut microbiota and well-being: A comprehensive summary of the special issue	47
Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond	47
Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome	47
Perturbations of CB1 receptor signalling during adolescence impair cortical myelination in female rats	47
Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice	47
Role of NSD1 as potential therapeutic target in tumor	47
Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio	46
New therapeutic avenues in multiple sclerosis: Is there a place for gut microbiota-based treatments?	46
Action and therapeutic targets of myosin light chain kinase, an important cardiovascular signaling mechanism	46
The role and potential mechanism of O-Glycosylation in gastrointestinal tumors	46
Design of the distribution of iron oxide (Fe3O4) nano-particle drug in realistic cholangiocarcinoma model and the simulation of temperature increase during magnetic induction hyperthermia	46
Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations	45
Corrigendum to “Paclitaxel-Ang-2-functionalized bionic mesoporous selenium nanoparticles for targeted therapy of glioma” [Pharmacol. Res. 216 (2025) 107783]	45
Nanotheranostics in cancer lymph node metastasis: The long road ahead	45
Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy	45
Neutrophils as potential therapeutic targets for breast cancer	45
A review of pharmacological and pharmacokinetic properties of Forsythiaside A	45
The role of androgens in women's health and wellbeing	45
Systemic administration of glucocorticoids, cardiovascular complications and mortality in patients hospitalised with COVID-19, SARS, MERS or influenza: A systematic review and meta-analysis of randomi	45
TRP channels in cancer: Therapeutic opportunities and research strategies	45
Elucidation of the anti-inflammatory mechanism of Er Miao San by integrative approach of network pharmacology and experimental verification	45
IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics	44
Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Aβ burden in early Alzheimer’s disease models	44
Ketogenic diet in children and adolescents: The effects on growth and nutritional status	44
The interplay of aging, sleep dysregulation, and mitochondrial dysfunction in metabolic and neurodegenerative diseases	44
Understanding the habenula: A major node in circuits regulating emotion and motivation	44
Zedoarondiol inhibits atherosclerosis by regulating monocyte migration and adhesion via CXCL12/CXCR4 pathway	44
(+)-trans-Cannabidiol-2-hydroxy pentyl is a dual CB1R antagonist/CB2R agonist that prevents diabetic nephropathy in mice	44
Post-stroke administration of H2 relaxin reduces functional deficits, neuronal apoptosis and immune cell infiltration into the mouse brain	44
Anticancer potential of allicin: A review	43
SNX17 protects the heart from doxorubicin-induced cardiotoxicity by modulating LMOD2 degradation	43
Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics	43
Acetylcholinesterase inhibitor ameliorates doxorubicin-induced cardiotoxicity through reducing RIP1-mediated necroptosis	43
Polyol pathway and redox balance in diabetes	43
Corrigendum to “Sugiol, a diterpenoid: Therapeutic actions and molecular pathways involved” Pharmacol. Res. 163 (2021) 105313	43
The ketogenic diet modulates tumor-associated neutrophil polarization via the AMOT-YAP/TAZ axis to inhibit colorectal cancer progression	42
Editorial Board	42
Corrigendum to “Dihydroartemisin inhibits glioma invasiveness via a ROS to P53 to β-catenin signaling” [Pharmacol. Res. 119 (2017) 72–88]	42
Mtnr1b deletion disrupts placental angiogenesis through the VEGF signaling pathway leading to fetal growth restriction	42
Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1	42
Clinical trials of orphan drugs in China over the decade 2012–2022: Opportunities and challenges	42
Paracetamol metabolism by endothelial cells – Potential mechanism underlying intravenous paracetamol-induced hypotension	42
Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy	41
Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases	41
Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders	41
β-amyloid’s neurotoxic mechanisms as defined by in vitro microelectrode arrays: a review	41
Medicinal Chemistry approach, pharmacology and neuroprotective benefits of CB2R modulators in neurodegenerative diseases	41
A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing	41
An ode to valproic acid: A letter to the editor	41
Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy	41
Breaking through the treatment desert of conventional mesothelin-targeted CAR-T cell therapy for malignant mesothelioma: A glimpse into the future	41
A novel approach to explore metabolic diseases: Neddylation	40
Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis	40
Crosstalk between extracellular vesicles and autophagy in cardiovascular pathophysiology	40
SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19	40
Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway	40
Crosstalk of miRNAs with signaling networks in bladder cancer progression: Therapeutic, diagnostic and prognostic functions	40
Ginsenoside Rb1 and berberine synergistically protect against type 2 diabetes mellitus via GDF15/HAMP pathway throughout the liver lobules: Insights from spatial transcriptomics analysis	40
Targeting systemic inflammation in metabolic disorders. A therapeutic candidate for the prevention of cardiovascular diseases?	40
A review of KLF4 and inflammatory disease: Current status and future perspective	40
Inhibition of long noncoding RNA Gm41724 alleviates pressure overload-induced cardiac fibrosis by regulating lamina-associated polypeptide 2α	40
The AIM2 inflammasome: A novel biomarker and target in cardiovascular disease	39
Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis	39
Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor	39
p53: A double-edged sword in tumor ferroptosis	39
D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription	39
Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases	39
ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis	39
Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis	39
Clinical experience with CTLA-4 blockade for cancer immunotherapy: From the monospecific monoclonal antibody ipilimumab to probodies and bispecific molecules targeting the tumor microenvironment	38
The potential role of mitochondria in the microbiota-gut-brain axis: Implications for brain health	38
HMGA2 regulation by miRNAs in cancer: Affecting cancer hallmarks and therapy response	38
RNA methylation and cancer treatment	38
Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancer	38
ABCB1 limits brain exposure of the KRASG12C inhibitor sotorasib, whereas ABCB1, CYP3A, and possibly OATP1a/1b restrict its oral availability	38
Therapeutic effects of curcumin liposomes and nanocrystals on inflammatory osteolysis: In vitro and in vivo comparative study	38
Topical VX-509 attenuates psoriatic inflammation through the STAT3/FABP5 pathway in keratinocytes	38
Biological activities, Molecular mechanisms, and Clinical application of Naringin in Metabolic syndrome	38
Circulating extracellular vesicles from patients with traumatic brain injury induce cerebrovascular endothelial dysfunction	38
Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models	37
Powering prescription: Mitochondria as “Living Drugs” – Definition, clinical applications, and industry advancements	37
BCAAs and Di-Alanine supplementation in the prevention of skeletal muscle atrophy: preclinical evaluation in a murine model of hind limb unloading	37
AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease	37
Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges	37
Vanillic acid restores homeostasis of intestinal epithelium in colitis through inhibiting CA9/STIM1-mediated ferroptosis	37
Diabetic retinopathy in the pediatric population: Pathophysiology, screening, current and future treatments	37