Pharmacological Research

Article	Citations
Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	448
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	415
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	200
Wogonin effects on the efflux transporters BCRP and MRP2, explain its effectiveness in ulcerative colitis: Implications for metabolic and transport interactions	196
Scutellarin inhibits pyroptosis via selective autophagy degradation of p30/GSDMD and suppression of ASC oligomerization	196
A comprehensive review on the plant sources, pharmacological activities and pharmacokinetic characteristics of Syringaresinol	179
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	175
Promising LOX proteins for cartilage-targeting osteoarthritis therapy	162
New therapeutic approaches in children’s medicine towards solving critical issues in pediatrics	159
Substance use disorders and cooperative research on addictions: Spanish approach as a model	159
NLRP3 inflammasome links vascular senescence to diabetic vascular lesions	154
From bench to bedside: Developing CRISPR/Cas-based therapy for ocular diseases	152
Quality and composition control of complex TCM preparations through a novel “Herbs-in vivo Compounds-Targets-Pathways” network methodology: The case of Lianhuaqingwen capsules	150
Reply to the letter comment of Su Boon Yong MD, PhD and colleagues to: Improved glycemic and weight control with Dulaglutide addition in SGLT2 inhibitor treated obese type 2 diabetic patients at high	145
IUPHAR review: Eating disorders, gut microbiota dysbiosis and epigenetic aberrations	142
PEPITEM, its tripeptide pharmacophores and their peptidomimetic analogues regulate the inflammatory response through parenteral and topical dosing in models of peritonitis and psoriasis	141
Suppression of macrophage migration by down-regulating Src/FAK/P130Cas activation contributed to the anti-inflammatory activity of sinomenine	138
Kallikrein inhibitor derived from immunoglobulin heavy chain junction region possesses anti-thromboinflammation potential	137
New insights into the role and therapeutic potential of HSP70 in diabetes	136
Chios mastiha essential oil exhibits antihypertensive, hypolipidemic and anti-obesity effects in metabolically unhealthy adults - a randomized controlled trial	130
Bufalin for an innovative therapeutic approach against cancer	129
Pharmacological regression of atherosclerotic plaque in patients with type 2 diabetes	125
Bioactive compounds in childhood obesity and associated metabolic complications: Current evidence, controversies and perspectives	123
Targeting cellular senescence in cancer by plant secondary metabolites: A systematic review	121
Effects of SGLT2 inhibition via empagliflozin on cognitive and physical impairment in frail diabetic elders with chronic kidney disease	117

Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	117
Lycorine suppresses the malignancy of breast carcinoma by modulating epithelial mesenchymal transition and β-catenin signaling	115
Improving the tumor selectivity of T cell engagers by logic-gated dual tumor-targeting	112
SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies	112
Editorial Board	107
Editorial Board	107
Demethylzeylasteral targets lactate to suppress the tumorigenicity of liver cancer stem cells: It is attributed to histone lactylation?	106
Editorial Board	103
Comment: Polymorphisms indicating risk of inflammatory bowel disease or antigenicity to anti-TNF drugs as biomarkers of response in children	98
Editorial Board	97
The novel role of glucocorticoid-induced leucine zipper as a marker of mucosal healing in inflammatory bowel diseases	96
Response to the comment on "SGLT-2 inhibitors reduce the risk of cerebrovascular/cardiovascular outcomes and mortality: A systematic review and meta-analysis of retrospective cohort studies"	96
Editorial Board	95
Vitamin D supplementation: an adjunct therapy for improving inflammatory and oxidative stress?	95
Exploring the pharmacological versatility of ficus carica: Modulating classical immunometabolism and beyond	95
Treating COVID-19 with NRICM101 and NRICM102 – Author’s reply 2	94
Comparative efficacy and rankings of therapeutics for ALK-positive non-small cell lung cancer with brain metastasis: Updated results from a Bayesian network analysis based on randomized controlled tri	93
Enhanced efficacy of formoterol-montelukast salt in relieving asthma features and in preserving β2-agonists rescue therapy	93
Editorial Board	92
Development status and prospects of international standardization of medical devices of Traditional Chinese Medicine	92
Key factors influencing the TCM nomenclature in international standards	86
Response to the comment “Is SGLT2i superior to DPP4i for primary and secondary prevention of cardiovascular diseases and death in patients with type 2 diabetes?”	86
Features and development trends in international standardization of Chinese materia medica in ISO/TC 249	86
Editorial Board	84
Editorial Board	83
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	82
Astaxanthin: A promising therapeutic agent for organ fibrosis	82
Mesenchymal stem cells plus bone repair materials as a therapeutic strategy for abnormal bone metabolism: Evidence of clinical efficacy and mechanisms of action implied	82
Evidence of a dual mechanism of action underlying the anti-proliferative and cytotoxic effects of ammonium-alkyloxy-stilbene-based α7- and α9-nicotinic ligands on glioblastoma cells	80
Mind over matter: the microbial mindscapes of psychedelics and the gut-brain axis	80
Efficacy and safety of liraglutide in type 2 diabetes mellitus patients complicated with coronary artery disease: A systematic review and meta-analysis of randomized controlled trials	79
Animal models to study pathogenesis and treatments of cardiac disorders in rheumatoid arthritis: Advances and challenges for clinical translation	77
Comparative effects of nutraceuticals on body weight in adults with overweight or obesity: A systematic review and network meta-analysis of 111 randomized clinical trials	77
Counteracting health risks by Modulating Homeostatic Signaling	76
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	76
Unravelling the impact of RNA methylation genetic and epigenetic machinery in the treatment of cardiomyopathy	76
Bedaquiline and Linezolid improve anti-TB treatment outcome in drug-resistant TB patients with HIV: A systematic review and meta-analysis	75
PCSK9 inhibition and broad health outcomes: A Mendelian randomization phenome‑wide association study	74
Biomimetic micelles to accurately regulate the inflammatory microenvironment for glomerulonephritis treatment	74
Downregulation of the farnesoid X receptor promotes colorectal tumorigenesis by facilitating enterotoxigenic Bacteroides fragilis colonization	74
Editorial Board	74
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	73
CERS4 predicts positive anti-PD-1 response and promotes immunomodulation through Rhob-mediated suppression of CD8+Tim3+ exhausted T cells in non-small cell lung cancer	71
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer’s disease	71
The VEGFs/VEGFRs system in Alzheimer’s and Parkinson’s diseases: Pathophysiological roles and therapeutic implications	70
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	70
Metasilicate-based alkaline mineral water confers diarrhea resistance in maternally separated piglets via the microbiota-gut interaction	69
Rho kinase inhibitors ameliorate cognitive impairment in a male mouse model of methamphetamine-induced schizophrenia	68
Targeting gut microbiota as a therapeutic target in T2DM: A review of multi-target interactions of probiotics, prebiotics, postbiotics, and synbiotics with the intestinal barrier	68
Do cytokines play a role in the transition from acute to chronic musculoskeletal pain?	68

Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	67
Aquaporin 11 alleviates retinal Müller intracellular edema through water efflux in diabetic retinopathy	67
Microsomal prostaglandin E2 synthase-1 and its inhibitors: Molecular mechanisms and therapeutic significance	67
Association of plasma levetiracetam concentration, MGMT methylation and sex with survival of chemoradiotherapy-treated glioblastoma patients	67
Dual biological therapy and small molecules in pediatric inflammatory bowel disease	66
The multifaceted anti-atherosclerotic properties of herbal flavonoids: A comprehensive review	65
Endogenous stimuli-responsive nanoparticles for cancer therapy: From bench to bedside	65
Editorial Board	65
Metabolic enzymes function as epigenetic modulators: A Trojan Horse for chromatin regulation and gene expression	65
Targeting Type I IFN/STAT1 signaling inhibited and reversed corneal squamous metaplasia in Aire-deficient mouse	65
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	65
Methodological considerations in assessing GLP-1 receptor agonists and gastrointestinal cancer risk	64
Erratum to “Cardiovascular disease: Mitochondrial dynamics and mitophagy crosstalk mechanisms with novel programmed cell death and macrophage polarisation” [Pharmacol Res 206 (2024) 107258]	64
Diversity, molecular mechanisms and structure-activity relationships of marine protease inhibitors—A review	64
Targeting hypoxia inducible factor-1 alpha in rheumatoid arthritis: Rationale, opportunities and challenges	63
Corrigendum to “Overcoming limitations and advancing the therapeutic potential of antibody-oligonucleotide conjugates (AOCs): Current status and future perspectives” [Pharmacol. Res. 209 (2024) 107469	63
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	63
The dynamic role of ferroptosis in cancer immunoediting: Implications for immunotherapy	62
Checkpoints and immunity in cancers: Role of GNG12	62
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities	62
Looking deeper into the findings of DARE-19: Failure or an open door to future success?	62
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	62
A multi-omics investigation of tacrolimus off-target effects on a proximal tubule cell-line	61
A Pharmacological perspective on the temporal properties of sweeteners	61
Potential therapeutic compounds from traditional Chinese medicine targeting endoplasmic reticulum stress to alleviate rheumatoid arthritis	61
Commentary on “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease: A population-based study”	61
Amplifying hepatic L-aspartate levels suppresses CCl4-induced liver fibrosis by reversing glucocorticoid receptor β-mediated mitochondrial malfunction	60
Efficacy of tripterygium glycosides (TG) in rheumatoid arthritis as a disease-modifying anti-rheumatic drug (DMARD) in combination with conventional DMARDs: A systematic review and meta-analysis of ra	60
Gut-vascular axis and postbiotics: The need for clear definitions and further research	59
The effect of tibolone treatment on lipid profile in women: A systematic review and dose-response meta-analysis of randomized controlled trials	58
Exploring the therapeutic potential of apabetalone in diabetic kidney disease: Bridging preclinical findings with clinical translation	58
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	58
Corrigendum to “DNA aptamers masking angiotensin converting enzyme 2 as an innovative way to treat SARS-CoV-2 pandemic”	57
Future of PD-1/PD-L1 axis modulation for the treatment of triple-negative breast cancer	57
Potential synthetic lethality for breast cancer: A selective sirtuin 2 inhibitor combined with a multiple kinase inhibitor sorafenib	55
Anti-rheumatic drug-induced hepatitis B virus reactivation and preventive strategies for hepatocellular carcinoma	55
Cromolyn Sodium differentially regulates human mast cell and mouse leukocyte responses to control allergic inflammation	55
Epoxymicheliolide directly targets histone H2B to inhibit neuroinflammation via recruiting E3 ligase RNF20	55
DNMT3a-mediated methylation of PSTPIP2 enhances inflammation in alcohol-induced liver injury via regulating STAT1 and NF-κB pathway	55
Pearson syndrome-like anemia induced by accumulation of mutant mtDNA and anemia with imbalanced white blood cell lineages induced by Drp1 deletion in a murine model	54
Deep learning applications for the accurate identification of low-transcriptional activity drugs and their mechanism of actions	54
Phenolipid JE improves metabolic profile and inhibits gluconeogenesis via modulating AKT-mediated insulin signaling in STZ-induced diabetic mice	54
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	54
Glucocorticoids and COVID-19	54
Nucleic acid therapy in pediatric cancer	54
Predicting mortality after hospitalisation for COPD using electronic health records	54
Celastrol inhibits lung cancer growth by triggering histone acetylation and acting synergically with HDAC inhibitors	54
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	53
Allosteric inhibition of HSP70 in collaboration with STUB1 augments enzalutamide efficacy in antiandrogen resistant prostate tumor and patient-derived models	53
Reply to the Comment on “1,8-Cineole ameliorates right ventricle dysfunction associated with pulmonary arterial hypertension by restoring connexin43 and mitochondrial homeostasis”	53
Efficacy of mucosal vaccination using a protozoan parasite as a vehicle for antigen delivery: IgG and neutralizing response after rectal administration of LeCoVax-2, a candidate vaccine against COVID-	53
Mirabegron-induced brown fat activation does not exacerbate atherosclerosis in mice with a functional hepatic ApoE-LDLR pathway	53
Emerging role for branched-chain amino acids metabolism in fibrosis	52
G protein coupled receptor 41 regulates fibroblast activation in pulmonary fibrosis via Gαi/o and downstream Smad2/3 and ERK1/2 phosphorylation	52
Ceramide kinase confers tamoxifen resistance in estrogen receptor-positive breast cancer by altering sphingolipid metabolism	52
Discoveries and future significance of research into amyloid-beta/α7-containing nicotinic acetylcholine receptor (nAChR) interactions	52
eATP and autoimmune diabetes	52
The role of pyroptosis in incomplete immune reconstitution among people living with HIV：Potential therapeutic targets	51
Potentiation and allosteric agonist activation of α7 nicotinic acetylcholine receptors: binding sites and hypotheses	51
Hydrogen sulfide and sulfaceutic or sulfanutraceutic agents: Classification, differences and relevance in preclinical and clinical studies	51
Hypoxia-induced circSTT3A enhances serine synthesis and promotes H3K4me3 modification to facilitate breast cancer stem cell formation	51
Selenium supplementation effect on glycemic control: A GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials	51
IUPHAR-review: Targeting the cytoskeleton as a therapeutic approach to substance use disorders	50
Prescribing statin therapy in physically (in)active individuals vs prescribing physical activity in statin-treated patients: A four-scenario practical approach	50
Pharmacometabolomics may be the next stamp in the pharmacogenetic passport	50
Selection strategy of second-line biologic therapies in adult patients with ulcerative colitis following prior biologic treatment failure: Systematic review and meta-analysis	50
Metabolic regulation of the Th17/Treg balance in inflammatory bowel disease	50
An account on the history of pharmacology in Spain	50
Progress in the development of modulators targeting Frizzleds	49
Relationship between clonal evolution and drug resistance in bladder cancer: A genomic research review	49
Commentary on “Mesothelin CAR-T cells expressing tumor-targeted immunocytokine IL-12 yield durable efficacy and fewer side effects”	49
Time-dependent proteomics and drug response in expanding cancer cells	49
PGC-1α loss promotes mitochondrial protein lactylation in acetaminophen-induced liver injury via the LDHB-lactate axis	49
Targeting the autoreactive CD8+ T-cell receptor in type 1 diabetes: Insights from scRNA-seq for immunotherapy	48
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	48
Cardiomyocyte-derived C-type natriuretic peptide diminishes myocardial ischaemic injury by promoting revascularisation and limiting fibrotic burden	48
Oligosaccharides from fucosylated glycosaminoglycan prevent breast cancer metastasis in mice by inhibiting heparanase activity and angiogenesis	48
Delineation of the functional properties exhibited by the Zinc-Activated Channel (ZAC) and its high-frequency Thr128Ala variant (rs2257020) in Xenopus oocytes	47
Immobilized protein strategies based on cell membrane chromatography and its application in discovering active and toxic substances in traditional Chinese medicine	47
A Saccharomyces boulardii-derived antioxidant protein, thioredoxin, ameliorates intestinal inflammation through transactivating epidermal growth factor receptor	46

TRIM47 accelerates aerobic glycolysis and tumor progression through regulating ubiquitination of FBP1 in pancreatic cancer	46
Developing patient-derived organoids to demonstrate JX24120 inhibits SAMe synthesis in endometrial cancer by targeting MAT2B	46
Identification of the TRPA1 cannabinoid-binding site	46
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	46
Orosomucoid 2 is an endogenous regulator of neuronal mitochondrial biogenesis and promotes functional recovery post-stroke	46
Glucagon-like peptide-1 receptor agonists and risk of gastrointestinal cancers: A systematic review and meta-analysis of randomized controlled trials	45
Tubocapsenolide A targets C-terminal cysteine residues of HSP90 to exert the anti-tumor effect	45
Unfolded protein response in the activation-induced biological processes of CD8+ T cells	45
Anti-thrombotic effects mediated by dihydromyricetin involve both platelet inhibition and endothelial protection	45
Excessive alcohol intake produces persistent mechanical allodynia and dysregulates the endocannabinoid system in the lumbar dorsal root ganglia of genetically-selected Marchigian Sardinian alcohol-pre	45
dCA1-NAc shell glutamatergic projection mediates context-induced memory recall of morphine	44
Synthesized nanoparticles, biomimetic nanoparticles and extracellular vesicles for treatment of autoimmune disease: Comparison and prospect	44
Second-generation antipsychotics induce cardiotoxicity by disrupting spliceosome signaling: Implications from proteomic and transcriptomic analyses	44
Autophagy in vascular dementia and natural products with autophagy regulating activity	44
Integrins play a role in stress relaxation of perivascular adipose tissue	44
Biased and allosteric modulation of bone cell-expressing G protein-coupled receptors as a novel approach to osteoporosis therapy	44
Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice	44
GADD45β stabilized by direct interaction with HSP72 ameliorates insulin resistance and lipid accumulation	44
Corrigendum to: Lianhuaqingwen exerts anti-viral and anti-inflammatory activity against novel coronavirus (SARS-CoV-2) [Pharmacol. Res. 156 (2020) 104761]	44
Photosensitizer IR700DX-6T- and IR700DX-mbc94-mediated photodynamic therapy markedly elicits anticancer immune responses during treatment of pancreatic cancer	44
The renin-angiotensin-aldosterone system: A century-old diversified system with several therapeutic avenues	43
Regulatory role of ncRNAs in pulmonary epithelial and endothelial barriers: Molecular therapy clues of influenza-induced acute lung injury	43
Epigenetic regulation of autophagy by non-coding RNAs in gastrointestinal tumors: Biological functions and therapeutic perspectives	43
Similarities and differences upon binding of naturally occurring Δ9-tetrahydrocannabinol-derivatives to cannabinoid CB1 and CB2 receptors	43
Deficiency of GFRα1 promotes hepatocellular carcinoma progression but enhances oxaliplatin-mediated anti-tumor efficacy	43
Komagataella pastoris KM71H modulates neuroimmune and oxidative stress parameters in animal models of depression: A proposal for a new probiotic with antidepressant-like effect	43
Corrigendum to “Anti-tumor effects of Skp2 inhibitor AAA-237 on NSCLC by arresting cell cycle at G0/G1 phase and inducing senescence” [Pharmacol. Res. 181 (2022), 106259]	42
Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora	42
Clinical pharmacology facing the real-world setting: Pharmacovigilance, pharmacoepidemiology and the economic evaluation of drugs	42
Corrigendum to: An account on the history of pharmacology in Spain [Pharmacol. Res. 202 (2024) 107104 Pages 1–11 https://doi.org/10.1016/j.phrs.2024.107104]	42
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	41
GPR108 is required for gambogic acid inhibiting NF-κB signaling in cancer	41
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	41
WITHDRAWN: JUN and ATF3 are deficient in prostate cancer patients and their delivery in vivo via lipid nanoparticles has therapeutic efficacy by enhancing immune surveillance	41
Crosstalk between non-coding RNAs expression profile, drug resistance and immune response in breast cancer	41
BKM120 alters the migration of doublecortin-positive cells in the dentate gyrus of mice	41
Biomarker discovery and application—An opportunity to resolve the challenge of liver cancer diagnosis and treatment	41
Nod-like receptors: The relevant elements of glioblastoma`s prognostic puzzle	41
Chinese herbal formula ruangan granule enhances the efficacy of entecavir to reverse advanced liver fibrosis/early cirrhosis in patients with chronic HBV infection: A multicenter, randomized clinical	41
Endoplasmic reticulum stress promotes breast cancer cells to release exosomes circ_0001142 and induces M2 polarization of macrophages to regulate tumor progression	41
Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates	41
Corrigendum to “CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism of ceRNA and promotes the growth of malignant glioma” [Pharmacol. Res. 197 (2023) 106979]	41
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	41
The ZDHHC13/ZDHHC17 subfamily: From biological functions to therapeutic targets of diseases	40
Natural products in non-alcoholic fatty liver disease (NAFLD): Novel lead discovery for drug development	40
Anti-metastatic effects of 1,2,3,4,6-Penta-O-galloyl-β-D-glucose in colorectal cancer: Regulation of cathepsin B-mediated extracellular matrix dynamics and epithelial-to-mesenchymal transition	40
Treating cancer through modulating exosomal protein loading and function: The prospects of natural products and traditional Chinese medicine	40
Disclosing the potential of eleganolone for Parkinson’s disease therapeutics: Neuroprotective and anti-inflammatory activities	40
From exosomes to mitochondria and myocardial infarction: Molecular insight and therapeutic challenge	40
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	40
Dioscin ameliorates murine ulcerative colitis by regulating macrophage polarization	39
Role of neuroglia in neuropathic pain and depression	39
IgD/FcδR is involved in T-cell acute lymphoblastic leukemia and regulated by IgD-Fc-Ig fusion protein	39
Exosomal miR-211-5p regulates glucose metabolism, pyroptosis, and immune microenvironment of melanoma through GNA15	39
Gut microbiota and neuropsychiatric disorders: Implications for neuroendocrine-immune regulation	39
Procyanidin B2 ameliorates endothelial dysfunction and impaired angiogenesis via the Nrf2/PPARγ/sFlt-1 axis in preeclampsia	38
Outcomes following KRASG12C inhibitor treatment in patients with KRASG12C-mutated solid tumors: A systematic review and meta-analysis	38
The bioenergetics of traumatic brain injury and its long-term impact for brain plasticity and function	38
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	38
New frontiers against sorafenib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers	38
When will the immune-stimulating antibody conjugates (ISACs) be transferred from bench to bedside?	38
EVA1B facilitates esophageal squamous carcinoma progression and recruitment of immunosuppressive myeloid-derived suppressor cells in the tumor microenvironment	38
MicroRNA-24-3p alleviates cardiac fibrosis by suppressing cardiac fibroblasts mitophagy via downregulating PHB2	38
Management of inflammation in cardiovascular diseases	38
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	38
Echinacoside: A promising active natural products and pharmacological agents	38
An overview of the pharmacological activities of scopoletin against different chronic diseases	37
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	37
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	37
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	37
The role of non-coding RNAs (miRNA and lncRNA) in the clinical management of rheumatoid arthritis	37
SGLT2-inhibitors are effective and safe in the elderly: The SOLD study	37
Lipid lowering combination therapy: From prevention to atherosclerosis plaque treatment	37
Targeting regulated cell death in aortic aneurysm and dissection therapy	37
Protective effect of berberine in diabetic nephropathy: A systematic review and meta-analysis revealing the mechanism of action	36
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	36
Macrophage 3D migration: A potential therapeutic target for inflammation and deleterious progression in diseases	36
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	36
Developing patient-derived organoids to predict PARP inhibitor response and explore resistance overcoming strategies in ovarian cancer	36
Extracellular vesicles DJ-1 derived from hypoxia-conditioned hMSCs alleviate cardiac hypertrophy by suppressing mitochondria dysfunction and preventing ATRAP degradation	36
Insight of neonicotinoid insecticides: Exploring exposure, mechanisms in non-target organisms, and removal technologies	36
The current landscape of antifibrotic therapy across different organs: A systematic approach	36
STC1 competitively binding βPIX enhances melanoma progression via YAP nuclear translocation and M2 macrophage recruitment through the YAP/CCL2/VEGFA/AKT feedback loop	36
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	36
Strategies for ectopic expression of specific genes to enhance CAR-T cell tumoricidal capacity: How far are we from the clinical practice?	36
Protective effect of Nr4a2 (Nurr1) against LPS-induced depressive-like behaviors via regulating activity of microglia and CamkII neurons in anterior cingulate cortex	36
The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategies	36
The evolving role of cholesteryl ester transfer protein inhibition beyond cardiovascular disease	35
Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective	35
Polypharmacology: The science of multi-targeting molecules	35
Lactobacillus acidophilus ameliorates obesity in mice through modulation of gut microbiota dysbiosis and intestinal permeability	35
Indacaterol, glycopyrronium, and mometasone: Pharmacological interaction and anti-inflammatory profile in hyperresponsive airways	35
Dietary genistein increases microbiota-derived short chain fatty acid levels, modulates homeostasis of the aging gut, and extends healthspan and lifespan	35
Oncogenic viruses and chemoresistance: What do we know?	35
Cucurbitacin B inhibits non-small cell lung cancer in vivo and in vitro by triggering TLR4/NLRP3/GSDMD-dependent pyroptosis	35