Pharmacological Research

Article	Citations
Decoding the Metabolic-immune Axis: Neutrophil glycolysis-driven tumor niche remodeling and its therapeutic exploitation	276
Editorial Board	256
Telmisartan reverses hepatic steatosis via PCK1 upregulation: A novel PPAR-independent mechanism in experimental models of MASLD	235
Impact of Sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer’s disease	223
Gut-vascular axis and postbiotics: The need for clear definitions and further research	200
An account on the history of pharmacology in Spain	195
NAFLD-associated hepatocellular carcinoma (HCC) – A compelling case for repositioning of existing mTORc1 inhibitors	188
ARID1A is a coactivator of STAT5 that contributes to CD8+ T cell dysfunction and anti-PD-1 resistance in gastric cancer	180
Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein	174
Chimeric cytokine receptor TGF-β RⅡ/IL-21R improves CAR-NK cell function by reversing the immunosuppressive tumor microenvironment of gastric cancer	159
Drug-induced atrial fibrillation. A narrative review of a forgotten adverse effect	154
Research progress on the interaction between oxidative stress and platelets: Another avenue for cancer?	151
Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies	150
Looking deeper into the findings of DARE-19: Failure or an open door to future success?	145
Natural HSP90 inhibitors as a potential therapeutic intervention in treating cancers: A comprehensive review	143
Present and future antipsychotic drugs: A systematic review of the putative mechanisms of action for efficacy and a critical appraisal under a translational perspective	137
Polypharmacology: The science of multi-targeting molecules	135
Cannabidiol alters mitochondrial bioenergetics via VDAC1 and triggers cell death in hormone-refractory prostate cancer	134
Echinatin inhibits the growth and metastasis of human osteosarcoma cells through Wnt/β-catenin and p38 signaling pathways	132
Piperlongumine synergistically enhances the antitumour activity of sorafenib by mediating ROS-AMPK activation and targeting CPSF7 in liver cancer	130
The specific deletion of cyclooxygenase-1 in megakaryocytes/platelets reduces intestinal polyposis in Apc mice	127
Organ-targeted biomarkers of sepsis: A systematic review reveals the value of inflammation and lipid metabolic dysregulation	126
Astaxanthin: A promising therapeutic agent for organ fibrosis	126
Combined effects of clonal hematopoiesis of indeterminate potential and P2Y12 inhibitors on outcomes of patients with ST-segment elevation myocardial infarction: A prospective study	119
Molecular mechanisms underlying hepatoprotective activity of lutein in the context of intestinal failure-associated liver disease	118

Hirsutine ameliorates hepatic and cardiac insulin resistance in high-fat diet-induced diabetic mice and in vitro models	114
Combination of palbociclib with navitoclax based-therapies enhances in vivo antitumoral activity in triple-negative breast cancer	113
G-protein biased signaling agonists of Dopamine D3 receptor promote distinct activation patterns of ERK1/2	110
Upgrade of chrysomycin A as a novel topoisomerase II inhibitor to curb KRAS-mutant lung adenocarcinoma progression	109
Corrigendum to ‘Dioscin attenuates renal ischemia/reperfusion injury by inhibiting the TLR4/MyD88 signaling pathway via up-regulation of HSP70′ [Pharmacol. Res. 100 (2015) 341–352]	108
Pharmacological rationale for the very early treatment of acute coronary syndrome with monoclonal antibodies anti-PCSK9	108
An oncolytic system produces oxygen selectively in pancreatic tumor cells to alleviate hypoxia and improve immune activation	107
Congenital diaphragmatic hernia increases the sensitivity of pulmonary arteries to nitric oxide	104
Genetic and pharmacological targeting of HINT2 promotes OXPHOS to alleviate inflammatory responses and cell necrosis in acute pancreatitis	102
Lysosomal-targeted doxorubicin delivery using RBC-derived vesicles to overcome drug-resistant cancer through mitochondrial-dependent cell death	102
Time-dependent proteomics and drug response in expanding cancer cells	101
Response to letter to the editor: Letter by Chen et al. regarding article, “Assessment of sodium-glucose cotransporter 2 inhibitors (SGLT2i) and other antidiabetic agents in Alzheimer's disease: A pop	101
Progress in the development of modulators targeting Frizzleds	99
The function and therapeutic potential of transfer RNA-derived small RNAs in cardiovascular diseases: A review	99
Simultaneously blocking ANGPTL3 and CD47 prevents the progression of atherosclerosis through regulating lipid metabolism, macrophagic efferocytosis and lipid peroxidation	98
Inhibition of gut microbial β-glucuronidase effectively prevents carcinogen-induced microbial dysbiosis and intestinal tumorigenesis	97
Relevance of mitochondrial oxidative stress to arrhythmias: Innovative concepts to target treatments	97
Therapeutic implications of sonic hedgehog pathway in metabolic disorders: Novel target for effective treatment	96
Chromatin factors: Ready to roll as biomarkers in metastatic colorectal cancer?	95
Sex differences in the weight response to GLP-1RA in people with type 2 diabetes. A long-term longitudinal real-world study	93
Dual BET/HDAC inhibition to relieve neuropathic pain: Recent advances, perspectives, and future opportunities	93
Long non-coding RNA (lncRNA) H19 in human cancer: From proliferation and metastasis to therapy	91
The role of exosomes derived from various sources in facilitating the healing of chronic refractory wounds	91
Phloretin ameliorates diabetes-induced endothelial injury through AMPK-dependent anti-EndMT pathway	90
Targeting regulated cell death in aortic aneurysm and dissection therapy	90
Quercetin encapsulated in folic acid-modified liposomes is therapeutic against osteosarcoma by non-covalent binding to the JH2 domain of JAK2 Via the JAK2-STAT3-PDL1	89
DNMT3a-mediated methylation of TCF21/hnRNPA1 aggravates hepatic fibrosis by regulating the NF-κB signaling pathway	88
Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020	87
Recent developments of topoisomerase inhibitors: Clinical trials, emerging indications, novel molecules and global sales	86
Efficacy of vitamin D supplementation as an adjunct therapy for improving inflammatory and oxidative stress biomarkers: An umbrella meta-analysis	84
Cordycepin alleviated metabolic inflammation in Western diet-fed mice by targeting intestinal barrier integrity and intestinal flora	84
Fluvoxamine alleviates bleomycin-induced lung fibrosis via regulating the cGAS-STING pathway	83
Paeoniflorin as a potential therapeutic agent for cerebrovascular diseases: A comprehensive review	83
Corrigendum to ‘Glabratephrin reverses doxorubicin resistance in triple negative breast cancer by inhibiting P-glycoprotein’ [Pharmacol. Res. 175 (2022) 105975]	82
Sailing south from regulations to strategies: Macau as a promising gateway for the export of proprietary Chinese medicines to ASEAN countries	81
Blocking ANGPTL3 and CD47 impact on atherosclerosis-correspondence	81
WITHDRAWN: Red blood cell-derived extracellular vesicles deliver NUP85 siRNA to alleviate MASLD through downregulating SLC27A1/PPAR-γ in hepatocyte	80
Profiling the impact of anti-human CD20 monoclonal antibodies on lymphocyte B cell subsets and their precursors in the bone marrow and in lymphoid tissues in an immunocompromised mouse engrafted with	79
Revisiting the renin-angiotensin-aldosterone system in the eye: Mechanistic insights and pharmacological targets	79
AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy	79
Multidisciplinary consensus on the diagnosis and management of patients with atypical Hemolytic Uremic Syndrome (complement-mediated TMA): Recommendations from Italian scientific societies, patient as	79
Sex-dependent efficacy of sphingosine-1-phosphate receptor agonist FTY720 in mitigating Huntington’s disease	79
Elevated activity of plasma dipeptidyl peptidase 4 upon stress can be targeted to reverse tumor immunosuppression	79
Targeted and cytotoxic inhibitors used in the treatment of lung cancers	78
Nasal accumulation and metabolism of Δ9-tetrahydrocannabinol following aerosol (‘vaping’) administration in an adolescent rat model	78
Metabolic disorders affecting the liver and heart: Therapeutic efficacy of miRNA-based therapies?	77
Role of Angiopoietin-Tie axis in vascular and lymphatic systems and therapeutic interventions	77
Natural compounds targeting YAP/TAZ axis in cancer: Current state of art and challenges	76
Net clinical benefit of a reduced dose of DOACs in non-valvular atrial fibrillation: A meta-analysis of randomized trials	75
Editorial Board	75

The complementary and alternative roles of elemene injection in cancer: An umbrella review	75
Expand available targets for CAR-T therapy to overcome tumor drug resistance based on the "Evolutionary Traps"	75
Naphthoquinone derivatives as P-glycoprotein inducers in inflammatory bowel disease: 2D monolayers, 3D spheroids, and in vivo models	74
ABCB1 and ABCG2 limit brain penetration and, together with CYP3A4, total plasma exposure of abemaciclib and its active metabolites	73
Pragmatic diagnostic and therapeutic algorithms to optimize new potassium binder use in cardiorenal disease	73
Atrial fibrillation: Epigenetic aspects and role of sodium-glucose cotransporter 2 inhibitors	72
DNA repair biomarkers to guide usage of combined PARP inhibitors and chemotherapy: A meta-analysis and systematic review	71
α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation	71
Microsomal glutathione transferase 1 controls metastasis and therapeutic response in melanoma	71
Corrigendum to “Deficiency in adiponectin exaggerates cigarette smoking exposure-induced cardiac contractile dysfunction: Role of autophagy” [Pharm. Res. 100 (2015) 175–89]	71
The action of curcumin against damage resulting from cerebral stroke: A systematic review	71
CircRNA in ocular neovascular diseases: Fundamental mechanism and clinical potential	70
Functional metabolomics revealed the dual-activation of cAMP-AMP axis is a novel therapeutic target of pancreatic cancer	70
Combining choline bitartrate and vitamin B12 ameliorates cognitive impairment in hypertensive elders with cognitive frailty	70
RNA-binding motif 4 promotes angiogenesis in HCC by selectively activating VEGF-A expression	70
A copper nanocluster-based multifunctional nanoplatform for augmented chemo/chemodynamic/photodynamic combination therapy of breast cancer	69
Remote ischemic conditioning attenuates blood-brain barrier disruption after recombinant tissue plasminogen activator treatment via reducing PDGF-CC	68
Ginsenoside Ro prevents endothelial injury via promoting Epac1/AMPK- mediated mitochondria protection in early diabetic retinopathy	68
Pharmacological targeting of G protein-coupled receptor heteromers	68
Pharmacological targeting of microglia dynamics in Alzheimer’s disease: Preclinical and clinical evidence	67
Evaluation of the analgesic effect of ɑ-lipoic acid in treating pain disorders: A systematic review and meta-analysis of randomized controlled trials	67
Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice	67
Astrocytic connexin43 in the medial prefrontal cortex regulates depressive- and anxiety-like behaviors via ATP release	67
The major histocompatibility complex participates in Parkinson’s disease	66
Hormesis: wound healing and fibroblasts	66
Role of hypoxia in cellular senescence	64
Regulation of nicotinic acetylcholine receptors by post-translational modifications	64
Medical treatment of weight loss in children and adolescents with obesity	64
Hydrogen sulfide regulates the redox state of soluble guanylate cyclase in CSE-/- mice corpus cavernosum microcirculation	64
TAK1 blockade as a therapy for retinal neovascularization	64
Sirtuin3 attenuates pressure overload-induced pathological myocardial remodeling by inhibiting cardiomyocyte cuproptosis	64
Pharmacological targeting of HMGB-1 translocation: A potential therapeutic strategy for COVID-19	63
A molecular perspective on mGluR5 regulation in the antidepressant effect of ketamine	63
Cannabinoid-mediated targeting of mitochondria on the modulation of mitochondrial function and dynamics	62
Protein-polysaccharide interactions for the fabrication of bioactive-loaded nanocarriers: Chemical conjugates and physical complexes	62
Single-cell RNA sequencing highlights the roles of C1QB and NKG7 in the pancreatic islet immune microenvironment in type 1 diabetes mellitus	62
A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating mφ polarization in TME	61
Mitochondria as an important target of metformin: The mechanism of action, toxic and side effects, and new therapeutic applications	60
Recent advances in glioma microenvironment-response nanoplatforms for phototherapy and sonotherapy	60
The natural product berberine synergizes with osimertinib preferentially against MET-amplified osimertinib-resistant lung cancer via direct MET inhibition	60
Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review	59
Hormesis: Wound healing and keratinocytes	59
IUPHAR Article: Psilocybin induces long-lasting effects via 5-HT2A receptors in mouse models of chronic pain	59
Ferritin nanoconjugates guide trastuzumab brain delivery to promote an antitumor response in murine HER2 + breast cancer brain metastasis	59
Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy	59
IUPHAR editorial: Emerging targets for the treatment of pain: Moving towards non-addicting therapeutics and new preclinical directions	58
Systematic druggable genome-wide Mendelian randomization to identify therapeutic targets and dominant flora for ulcerative colitis	58
Commentary on “Apabetalone, a BET protein inhibitor, inhibits kidney damage in diabetes by preventing pyroptosis via modulating the P300/H3K27ac/PLK1 axis”	58
Corrigendum to “Ectopic expression of NKG7 enhances CAR-T function and improves the therapeutic efficacy in liquid and solid tumors” [Pharmacol. Res. 210 (2024) 107506]	58
Hv1 channel in immune cells and pharmacology	57
The interplay of aging, sleep dysregulation, and mitochondrial dysfunction in metabolic and neurodegenerative diseases	57
Editorial Board	57
Corrigendum to “Paclitaxel-Ang-2-functionalized bionic mesoporous selenium nanoparticles for targeted therapy of glioma” [Pharmacol. Res. 216 (2025) 107783]	57
TRP channels in cancer: Therapeutic opportunities and research strategies	57
Perturbations of CB1 receptor signalling during adolescence impair cortical myelination in female rats	56
Multitarget ligands that comprise opioid/nonopioid pharmacophores for pain management: Current state of the science	55
Gut microbiota and well-being: A comprehensive summary of the special issue	55
Editorial Board	54
Application of carbon monoxide in kidney and heart transplantation: A novel pharmacological strategy for a broader use of suboptimal renal and cardiac grafts	54
New therapies towards a better glycemic control in youths with type 1 diabetes	54
Ferroportin 1 depletion in neural stem cells promotes hippocampal neurogenesis and cognitive function in mice	54
Preclinical development of a standardized extract of Ilex paraguariensis A.St.-Hil for the treatment of obesity and metabolic syndrome	54
Action and therapeutic targets of myosin light chain kinase, an important cardiovascular signaling mechanism	54
Special Issue Spanish Basic and Clinical Pharmacology	53
New therapeutic avenues in multiple sclerosis: Is there a place for gut microbiota-based treatments?	53
MAO inhibitors for treatment-resistant depression: Bringing an updated perspective on pioneering drugs	53
Gut microbiota-driven metabolic alterations reveal the distinct pathogenicity of chemotherapy-induced cachexia in gastric cancer	53
Targeting LRP6: A new strategy for cancer therapy	53
A panel of altered blood oxysterols in patients with mild cognitive impairment: A novel combined diagnostic marker	53
Treating COVID-19 with NRICM101 and NRICM102 – Author’s reply 3	52
Novel mesothelin-targeted chimeric antigen receptor-modified UNKT cells are highly effective in inhibiting tumor progression	52
Post-stroke administration of H2 relaxin reduces functional deficits, neuronal apoptosis and immune cell infiltration into the mouse brain	52
Role of NSD1 as potential therapeutic target in tumor	52
Kallistatin leads to cognition impairment via downregulating glutamine synthetase	51
Game-changer in the fight against Huntington's disease: Cholesterol nanoparticles restore brain function in mice	51
Potential of diterpenes as antidiabetic agents: Evidence from clinical and pre-clinical studies	51
The α9α10 acetylcholine receptor: A non-neuronal nicotinic receptor	51
Efficacy and safety of Qingda granule versus valsartan capsule in Chinese grade 1 hypertensive patients with low-moderate risk: A randomized, double-blind, double dummy, non-inferiority, multi-center	50
Dietary lipid droplet structure in postnatal life improves hepatic energy and lipid metabolism in a mouse model for postnatal programming	50
Functional significance of O-linked N-acetylglucosamine protein modification in regulating autophagy	50

Establishment of an inducible cell line for Hepatitis B virus genotype C2 and its pharmacological responses to interferons	50
Systemic administration of glucocorticoids, cardiovascular complications and mortality in patients hospitalised with COVID-19, SARS, MERS or influenza: A systematic review and meta-analysis of randomi	49
Therapeutical peptides – Rapidly developing pharmaceutical landscape	49
Editorial Board	49
Corrigendum to “A novel immune checkpoint siglec-15 antibody inhibits LUAD by modulating mφ polarization in TME” [Pharmacol. Res. 181 (2022) 106269]	49
Cucurbitacin B: A review of its pharmacology, toxicity, and pharmacokinetics	49
Manuka honey activates the aryl hydrocarbon receptor: Implications for skin inflammation	49
Ketogenic diet in children and adolescents: The effects on growth and nutritional status	49
MicroRNA-based therapeutics for inflammatory disorders of the microbiota-gut-brain axis	48
ER-organelle contacts: A signaling hub for neurological diseases	48
Effects of exogenous melatonin supplementation on health outcomes: An umbrella review of meta-analyses based on randomized controlled trials	48
Anti-inflammatory and immunomodulatory activity of Mangifera indica L. reveals the modulation of COX-2/mPGES-1 axis and Th17/Treg ratio	48
IUPHAR Review - Bivalent and bifunctional opioid receptor ligands as novel analgesics	48
Anti-neuropathic pain activity of Ajugarin-I via activation of Nrf2 signaling and inhibition of TRPV1/TRPM8 nociceptors in STZ-induced diabetic neuropathy	47
Neutrophils as potential therapeutic targets for breast cancer	47
Long noncoding RNA p21 enhances autophagy to alleviate endothelial progenitor cells damage and promote endothelial repair in hypertension through SESN2/AMPK/TSC2 pathway	47
Therapeutic induction of energy metabolism reduces neural tissue damage and increases microglia activation in severe spinal cord injury	47
Anticancer potential of allicin: A review	47
Alternative splicing: A key regulator in T cell response and cancer immunotherapy	47
Leveraging HER2-targeted biparatopic antibodies in solid tumors	47
Mitochondria-targeted hydrogen sulfide donor reduces fatty liver and obesity in mice fed a high fat diet by inhibiting de novo lipogenesis and inflammation via mTOR/SREBP-1 and NF-κB signaling pathway	47
The role and potential mechanism of O-Glycosylation in gastrointestinal tumors	46
Elucidation of the anti-inflammatory mechanism of Er Miao San by integrative approach of network pharmacology and experimental verification	46
Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations	46
Nanotheranostics in cancer lymph node metastasis: The long road ahead	45
Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity	45
Polyol pathway and redox balance in diabetes	45
Dapagliflozin acutely improves kidney function in type 2 diabetes mellitus. The PRECARE study	45
Understanding the habenula: A major node in circuits regulating emotion and motivation	45
Role for the F-box proteins in heart diseases	45
Design of the distribution of iron oxide (Fe3O4) nano-particle drug in realistic cholangiocarcinoma model and the simulation of temperature increase during magnetic induction hyperthermia	45
Zedoarondiol inhibits atherosclerosis by regulating monocyte migration and adhesion via CXCL12/CXCR4 pathway	44
Regulation of glycolysis-derived L-lactate production in astrocytes rescues the memory deficits and Aβ burden in early Alzheimer’s disease models	44
Corrigendum to “Dihydroartemisin inhibits glioma invasiveness via a ROS to P53 to β-catenin signaling” [Pharmacol. Res. 119 (2017) 72–88]	43
Breaking through the treatment desert of conventional mesothelin-targeted CAR-T cell therapy for malignant mesothelioma: A glimpse into the future	43
Acetylcholinesterase inhibitor ameliorates doxorubicin-induced cardiotoxicity through reducing RIP1-mediated necroptosis	43
Lipoxin-mediated signaling: ALX/FPR2 interaction and beyond	43
KV11.1 (hERG1)-centered macromolecular membrane complexes regulate proliferation in B cell lymphomas and constitute novel pharmacological targets	43
Mtnr1b deletion disrupts placental angiogenesis through the VEGF signaling pathway leading to fetal growth restriction	43
Topical VX-509 attenuates psoriatic inflammation through the STAT3/FABP5 pathway in keratinocytes	42
D-arabinose acts as antidepressant by activating the ACSS2-PPARγ/TFEB axis and CRTC1 transcription	42
A hepatocellular carcinoma model with and without parenchymal liver damage that integrates technical and pathophysiological advantages for therapy testing	42
Editorial Board	42
An ode to valproic acid: A letter to the editor	42
S-glutathionylation in cancer: from fundamental mechanisms to clinical applications	42
Powering prescription: Mitochondria as “Living Drugs” – Definition, clinical applications, and industry advancements	42
Corrigendum to “Sugiol, a diterpenoid: Therapeutic actions and molecular pathways involved” Pharmacol. Res. 163 (2021) 105313	42
The ketogenic diet modulates tumor-associated neutrophil polarization via the AMOT-YAP/TAZ axis to inhibit colorectal cancer progression	42
ABCB1 limits brain exposure of the KRASG12C inhibitor sotorasib, whereas ABCB1, CYP3A, and possibly OATP1a/1b restrict its oral availability	41
Paracetamol metabolism by endothelial cells – Potential mechanism underlying intravenous paracetamol-induced hypotension	41
Gut microbiota-derived metabolite phenylacetylglutamine in cardiovascular and metabolic diseases	41
Targeting regulated cell death (RCD) with naturally derived sesquiterpene lactones in cancer therapy	41
Clinical trials of orphan drugs in China over the decade 2012–2022: Opportunities and challenges	41
Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis	41
A review of KLF4 and inflammatory disease: Current status and future perspective	41
Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models	41
A novel approach to explore metabolic diseases: Neddylation	41
Gut Clostridium sporogenes-derived indole propionic acid suppresses osteoclast formation by activating pregnane X receptor	40
Diabetic retinopathy in the pediatric population: Pathophysiology, screening, current and future treatments	40
Circulating extracellular vesicles from patients with traumatic brain injury induce cerebrovascular endothelial dysfunction	40
Ginsenoside Rb1 and berberine synergistically protect against type 2 diabetes mellitus via GDF15/HAMP pathway throughout the liver lobules: Insights from spatial transcriptomics analysis	39
Clinical experience with CTLA-4 blockade for cancer immunotherapy: From the monospecific monoclonal antibody ipilimumab to probodies and bispecific molecules targeting the tumor microenvironment	39
Innovative thiosemicarbazones that induce multi-modal mechanisms to down-regulate estrogen-, progesterone-, androgen- and prolactin-receptors in breast cancer	39
The potential role of mitochondria in the microbiota-gut-brain axis: Implications for brain health	39
Circulating cytokines and risk of developing hypertension: A systematic review and meta-analysis	39
Crosstalk of miRNAs with signaling networks in bladder cancer progression: Therapeutic, diagnostic and prognostic functions	39
β-amyloid’s neurotoxic mechanisms as defined by in vitro microelectrode arrays: a review	39
Biological activities, Molecular mechanisms, and Clinical application of Naringin in Metabolic syndrome	39
p53: A double-edged sword in tumor ferroptosis	39
Therapeutic effects of curcumin liposomes and nanocrystals on inflammatory osteolysis: In vitro and in vivo comparative study	38
Beyond metabolic messengers: Bile acids and TGR5 as pharmacotherapeutic intervention for psychiatric disorders	38
Targeting systemic inflammation in metabolic disorders. A therapeutic candidate for the prevention of cardiovascular diseases?	38
Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy	38
The AIM2 inflammasome: A novel biomarker and target in cardiovascular disease	38
Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges	38
HMGA2 regulation by miRNAs in cancer: Affecting cancer hallmarks and therapy response	38
Correspondence “Validation of fermentation techniques for prebiotic impact on gut microbiota”	37
Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases	37
RNA methylation and cancer treatment	37
AlphaFold-based AI docking reveals AMPK/SIRT1-TFEB pathway modulation by traditional Chinese medicine in metabolic-associated fatty liver disease	37
Inhibition of long noncoding RNA Gm41724 alleviates pressure overload-induced cardiac fibrosis by regulating lamina-associated polypeptide 2α	37
SARS-CoV-2 mitochondrial metabolic and epigenomic reprogramming in COVID-19	37
Stem cells therapy in neurodegenerative and neuroimmune diseases: Current status of treatments and future prospects	37
Kinsenoside attenuates liver fibro-inflammation by suppressing dendritic cells via the PI3K-AKT-FoxO1 pathway	37
Vanillic acid restores homeostasis of intestinal epithelium in colitis through inhibiting CA9/STIM1-mediated ferroptosis	37
ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis	37
Ginkgolide B targets and inhibits creatine kinase B to regulate the CCT/TRiC-SK1 axis and exerts pro-angiogenic activity in middle cerebral artery occlusion mice	36
Hydroxycarboxylic acid receptor 3 and GPR84 – Two metabolite-sensing G protein-coupled receptors with opposing functions in innate immune cells	36
Novel therapeutic strategies targeting UCP2 in uterine leiomyosarcoma	36
Corrigendum to “Anlotinib combined with osimertinib reverses acquired osimertinib resistance in NSCLC by targeting the c-MET/MYC/AXL axis” [Pharmacol. Res. 188 (2023) 106668]	36
Cardiomyocytes, cardiac endothelial cells and fibroblasts contribute to anthracycline-induced cardiac injury through RAS-homologous small GTPases RAC1 and CDC42	36
Methodological innovations in AI-assisted Chinese patent medicine prescribing	36
Single-cell RNA-sequencing data reveals the genetic source of extracellular vesicles in esophageal squamous cell carcinoma	36
Photopharmacological manipulation of amygdala metabotropic glutamate receptor mGlu4 alleviates neuropathic pain	36
Critical review on anti-obesity effects of phytochemicals through Wnt/β-catenin signaling pathway	36