OOIR: Observatory of International Research

Papers

(The TQCC of American Journal of Respiratory Cell and Molecular Biology is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-12-01 to 2025-12-01.)

Article	Citations
Novel Hemodynamic, Vascular Lesion, and Cytokine/Chemokine Differences Regarding Sex in a Pulmonary Arterial Hypertension Model	188
Toward Human Lung Regeneration: Gaining Insights from the Axolotl Salamander Ambystoma mexicanum	82
Pseudomonas aeruginosa Lipid A Structural Variants Induce Altered Immune Responses	67
Spotlighting “Neutrophil Elastase Triggers the Release of Macrophage Extracellular Traps”: A New Catch in Cystic Fibrosis?	57
Gene-ius at Work: Decoding Cell States through Expression	57
LPS Increases Artery but Not Airway Contraction in Precision-Cut Lung Slices from a Mouse Model of Acute Respiratory Distress Syndrome	56
Molecular Maestro in the Lung: The Sphingolipid Rheostat	52
Targeting S1PR2 in Sepsis, One Fragmented Mitochondrion at a Time	49
Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease	45
Temporal Release of IL-1 Family Members from Virally Infected Airway Epithelial Cells Suggests IL-36γ Is the Early Responder	44
Sputum Metabolomic Signature and Dynamic Change of Cough Variant Asthma	43
Cardiac and Pulmonary Vascular Dysfunction in Vitamin D–Deficient Bmpr2-Mutant Rats	43
Intestinal Microbiota-derived Propionic Acid Protects against Zinc Oxide Nanoparticle–induced Lung Injury	41
MOTS-c Promotes Glycolysis via AMPK–HIF-1α–PFKFB3 Pathway to Ameliorate Cardiopulmonary Bypass–induced Lung Injury	41
Starving a Cell Promotes Airway Smooth Muscle Relaxation: Inhibition of Glycolysis Attenuates Excitation–Contraction Coupling	40
Plasma Proteome Profiles Associated with Early Development of Lung Injury in Extremely Preterm Infants	38
CXCL14 Protects against Polymicrobial Sepsis by Enhancing Antibacterial Functions of Macrophages	34
New Insights Relating Gasdermin B to the Onset of Childhood Asthma	34
Loss of Tbx4 Affects Postnatal Lung Development and Predisposes to Pulmonary Hypertension	33
Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis	31
Impact of Canadian Wildfire Smoke Exposure on Nasal Inflammation Markers in New York City Residents	31
IL-1β Induces a Proinflammatory Fibroblast Microenvironment that Impairs Lung Progenitors’ Function	30
Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury	27
October Highlights/Papers by Junior Investigators/NIH News	26
Long Story Short: Understanding Isoform-Specific Expression of FAM13A	26

MLKL Protects Pulmonary Endothelial Cells in Acute Lung Injury	26
July Highlights/Papers by Junior Investigators/NIH News	26
Yield and Diversity of Human Distal Lung Epithelial Cells Isolated by Different Sorting Strategies	25
MicroRNA Control Lipid-laden Alveolar Macrophages in Smokers: A Potential Therapeutic Target for Chronic Obstructive Pulmonary Disease?	25
December Highlights/Papers by Junior Investigators/NIH News	24
SUMO Wrestling in the Airway Epithelium: Does It Regulate Thymic Stromal Lymphopoietin?	24
Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRA⁺Myofibroblast	24
First Steps toward Personalized Therapies for ABCA3 Deficiency	24
Expression of ACE2—a Key SARS-CoV-2 Entry Factor—Is Not Increased in the Nasal Mucosa of People with Cystic Fibrosis	23
A Mixed Blood-Lymphatic Endothelial Cell Phenotype in Lymphangioleiomyomatosis and Idiopathic Pulmonary Fibrosis but Not in Kaposi’s Sarcoma or Tuberous Sclerosis Complex	22
Exposure to Urban Air Pollution Particulate Matter Modifies Th1/Th2 Mtb Immunity in the Human Lung	22
IGFBP7 Contributes to EndMT and Serves as Biomarker for Right Ventricular Dysfunction in Pulmonary Arterial Hypertension	21
Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2	21
Macrophage CCL18 Promotes Lung Inflammation in Checkpoint Inhibitor Pneumonitis	20
Circulating Myeloid Cell–derived Extracellular Vesicles as Mediators of Indirect Acute Lung Injury	20
Enhancing the Anti-Fibrotic Potential of the Endothelium: Lipid Nanoparticles to the Rescue	20
CSP7 Protects Alveolar Epithelial Cells by Targeting p53-Fibrinolytic Pathways During Lung Injuries	20
Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice	20
The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures	20
When a DEAD-Box Protein Is the Key: A Novel Role for DDX5 in Lung Pericyte Dysfunction	20
Convergent Evidence SupportsTH2LCRRas a Novel Asthma Susceptibility Gene	20
Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor	19
ATP12A: Connecting Mucus and Fibrosis in Idiopathic Pulmonary Fibrosis	19
Interstitial Macrophages Mediate Efferocytosis of Alveolar Epithelium during Influenza Infection	19
KAT’s in the Cradle: p300/CBP and Regulation of HIF-1 and Blood Pressure during Intermittent Hypoxia	19
A Murine Model of Mycobacterium abscessus Infection Mimics Pathology of Chronic Human Lung Disease	19
Tartrate-Resistant Acid Phosphatase 5 (TRAP5) Promotes Eosinophil Migration During Allergic Asthma	19
A Glowing Opportunity to Target YAP in Lung Fibrosis	19
Chronic Marijuana Use Is Associated with Gene Expression Changes in BAL	19
Multiple Fibroblast Subtypes Contribute to Matrix Deposition in Pulmonary Fibrosis	19
Entering the Ring: Circular RNA in Pulmonary Macrophage Antibacterial Responses	18
Akt-driven TGF-β and DKK1 Secretion Impairs F508del Cystic Fibrosis Airway Epithelium Polarity	18
Cough-Variant Asthma: The Asthma Phenotype No One Coughs About	18
Enhanced Gαq Signaling in TSC2-Deficient Cells Is Required for Their Neoplastic Behavior	18
October Highlights/Papers by Junior Investigators/NIH News	18
Achieving Excellence and Engaging Members	18
When It Comes to COVID-19, Inflammation Is All the RAGE	18
AKT Phosphorylates FAM13A and Promotes Its Degradation via CUL4A/DDB1/DCAF1 E3 Complex	18
Whole-Genome Methylation Sequencing Reveals that COVID-19–induced Epigenetic Dysregulation Remains 1 Year after Hospital Discharge	17
The Homeobox Transcription Factor CUX1 Coordinates Postnatal Epithelial Developmental Timing but Is Dispensable for Lung Organogenesis and Regeneration	17
PINK1/PARKIN-mediated Mitophagy: Friend or Foe in Hypoxia-induced Pulmonary Vascular Remodeling?	17
Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-Driven Pulmonary Hypertension by Suppressing HIF-2α	17
Adenovirus-mediated Overexpression of FcγRIIB Attenuates Pulmonary Inflammation and Fibrosis	17
von Willebrand Factor: An Unhealthy Bond between Lung Endothelium and Pulmonary Fibrosis	17
Time Is Running Out in Pulmonary Arterial Hypertension: The Epigenetic Clock Is Clicking	17
TRPV4 Regulates the Macrophage Metabolic Response to Limit Sepsis-induced Lung Injury	17
LKB1 Regulates Pulmonary Hypertension Endothelial Cell Mitochondria: Another Layer of the Pulmonary Vascular Onion?	17
Lung Interstitial Macrophages Can Present Soluble Antigens and Induce Foxp3⁺ Regulatory T Cells	17
A Single-Cell RNA Sequencing Atlas of the Chronic Obstructive Pulmonary Disease Distal Lung to Predict Cell–Cell Communication	16
Soluble E-Cadherin Contributes to Airway Inflammation in Severe Asthma	16

Acidic Enough for a Healthy Breath	16
Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1 Pathway during Acute Respiratory Syncytial Virus Infection	16
Urokinase Plasminogen Activator Receptor Attenuates Allergen-induced Eosinophil Migration and Airway Hyperresponsiveness	16
Protective Role of Apelin in a Mouse Model of Post-Intensive Care Syndrome	16
A Unique CD27^-IgD^- B Cell Population in the Sputum of Severe Eosinophilic Asthma Associated with Airway Autoimmunity	16
Loss of Pulmonary Endothelial Cells in Emphysema Impairs Support of Human Alveolar Epithelial Cell Growth	16
Peripheral Blood Omics and Other Multiplex-based Systems in Pulmonary and Critical Care Medicine	16
2022-2023 Journal Award Winners	16
SART3 Activates CD36 Transcription by Recruiting FOXM1 and Activates PARP to Augment Cisplatin Resistance in Non-Small Cell Lung Cancer	16
IRAK2 Ubiquitination Mediated by PELI1 Impairs Airway Epithelial Function and Accelerates Pediatric Asthma	16
Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection	15
Improving Mitochondrial Function in Viral Infection: Targeting Cellular Metabolism	15
Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle	15
Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment	15
Ectopic Expression of MUC5B in the Respiratory Bronchiole Initiates Endoplasmic Reticulum Stress in the IPF Lung	15
Chronic Alcohol Intake Compromises Lung Immunity by Altering Immunometabolism in Humans and Mouse Models	15
A Locus on Chromosome 15 Contributes to Acute Ozone-induced Lung Injury in Collaborative Cross Mice	15
April Highlights/Papers by Junior Investigators/NIH News	14
Role of KCNK3 Dysfunction in Dasatinib-associated Pulmonary Arterial Hypertension and Endothelial Cell Dysfunction	14
From Protein Folding to Precision Therapy: Surfactant Protein A in the Spotlight	14
Fighting the Fiber: Targeting Collagen in Lung Fibrosis	14
Demystifying Bitter Taste Receptor Relaxation of Airway Smooth Muscle	14
Oxidized Phosphatidylcholines Trigger TRPA1 and Ryanodine Receptor–dependent Airway Smooth Muscle Contraction	14
Cell Culture Differentiation and Proliferation Conditions Influence the In Vitro Regeneration of the Human Airway Epithelium	14
Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways	13
Pirfenidone Mitigates Transforming Growth Factor-β–induced Inflammation after Viral Infection	13
Redox-Dependent Activation of Lung Epithelial STAT3 Is Required for Inducible Protection against Bacterial Pneumonia	13
Biomarkers of Fibrosis in Patients with COVID-19 One Year After Hospital Discharge: A Prospective Cohort Study	13
TMPRSS11E-dward Scissorhands? Proteolysis Potentiates Lung Inflammation during Pathogen Insult	13
Unveiling Organ Failure in the Critically Ill: Insights through the Metabolite Lens	12
Searching for an Animal Model with Clinical Features of Scleroderma	12
Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis	12
Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells	12
January Highlights/Papers by Junior Investigators/NIH News	12
Comparison of Droplet- and Microwell-based Methods to Analyze Cryopreserved Human BAL Cells by Single-Cell RNA Sequencing	12
Targeting CELA1 to Improve Septation in the Mouse Hyperoxia Model of Impaired Alveolar Development	12
Alveolar and Bone Marrow–derived Macrophages Differ in Metabolism and Glutamine Utilization	12
Food for Thought: The Emerging Role of Intestinal Microbiota in Pulmonary Arterial Hypertension	12
Mitochondria-derived Vesicle Packaging as a Novel Therapeutic Mechanism in Pulmonary Hypertension	12
Leveraging Microbial Symbiosis to Modulate Bronchopulmonary Dysplasia	12
Loss of Iron Regulatory Protein 2 Protects Mice from Lung Inflammation during Bronchoconstriction	12
An Antiviral Effect of Linoleic Acid Against Rhinovirus Infection	12
Alpha-1 Antitrypsin Deficiency: Does Increased Neutrophil Adhesion Contribute to Lung Damage?	12
Therapeutic Potential of Sodium Houttuyfonate in Pulmonary Hypertension through Orai-Ca²⁺ Channels	12
Sodium Houttuyfonate Alleviates Monocrotaline-induced Pulmonary Hypertension by Regulating Orai1 and Orai2	12
Plk1 Regulates Caspase-9 Phosphorylation at Ser-196 and Apoptosis of Human Airway Smooth Muscle Cells	12
Prenatal LPS Exposure Promotes Allergic Airway Inflammation via Long Coding RNA NONMMUT033452.2, and Protein Binding Partner, Eef1D	12
Airway Immune Signatures in Severe and Fatal Infection with COVID-19	12
February Highlights/Papers by Junior Investigators/NIH News	11
Tipping the Balance of Ubiquitination toward a Therapy for COVID-19	11
Chronic Obstructive Pulmonary Disease Airway Epithelial Cell–derived Extracellular Vesicles Spread Cellular Senescence via MicroRNA-34a	11
A NEAT Discovery Hints at Altered Golgi Signaling in Lung Fibrosis	11
Asporin Promotes TGF-β–induced Lung Myofibroblast Differentiation by Facilitating Rab11-Dependent Recycling of TβRI	11
HDAC6: A Neglected Player in Chronic Obstructive Pulmonary Disease?	11
Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity	11
Thioredoxin Prevents Loss of UCP2 in Hyperoxia via MKK4–p38 MAPK–PGC1α Signaling and Limits Oxygen Toxicity	11
Drivers of Type 2 Inflammation in Allergic Airway Disease: Wnt You Like to Know?	11
A Novel Role for γδ T Cells in Protection Against Severe Melioidosis	11
Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity	11
HPS6 Deficiency Leads to Reduced Vacuolar-Type H⁺-ATPase and Impaired Biogenesis of Lamellar Bodies in Alveolar Type II Cells	11
Does “Skippy” Wheeze? Evidence of Airway Remodeling in the Australian Kangaroo	11
DNA–Protein Kinase Catalytic Subunit as a Potential Target for Pulmonary Arterial Hypertension	11
Recessive Mutations in CFAP74 Cause Primary Ciliary Dyskinesia with Normal Ciliary Ultrastructure	11
SOX17 Prevents Endothelial–Mesenchymal Transition of Pulmonary Arterial Endothelial Cells in Pulmonary Hypertension through Mediating TGF-β/Smad2/3 Signaling	11
Cell Surface RNA Expression Modulates Alveolar Epithelial Function	10
Pulmonary Microvascular Endothelial Cells Support Alveolar Epithelial Growth via Bone Morphogenetic Protein 6 Secretion	10
Cytokine Regulation by Alpha-1 Antitrypsin Therapy: A Pathway Analysis of a Pilot Clinical Trial	10
Pedal to the Metal: Iron Regulation of Aspergillus fumigatus Protease Production	10
Pulmonary and Nonpulmonary Sepsis Differentially Modulate Lung Immunity toward Secondary Bacterial Pneumonia: A Critical Role for Alveolar Macrophages	10
September Highlights/Papers by Junior Investigators/NIH News	10
Dual Pigment Epithelium-derived Factor and Hepatocyte Growth Factor Overexpression: A New Therapy for Pulmonary Hypertension	10
Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer	10
A New Methodology for the Oxygen Measurement in Lung Tissue of an Aged Ferret Model Proves Hypoxia during COVID-19	10
The Transcriptional Landscape of Developing Human Trisomy 21 Lungs	10
The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia	10
Breath Markers of Oxidative Stress in Children with Severe Viral Lower Respiratory Tract Infection	10
July Highlights/Papers by Junior Investigators/NIH News	10
Identification of circSlc7a11, a Novel circRNA that Functions as a Negative Regulator of Host Immune Defense Against Pulmonary Pseudomonas aeruginosa Infection	9
Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p	9
Preventable ATII Proliferation after Hyperoxia: The “Tempo” of Folate Metabolism in the Neonatal Lung	9

Alveolar Epithelial Cell Dysfunction in Idiopathic Pulmonary Fibrosis Linked to Lipid Alterations: Therapeutic Implications	9
Amphipathic Helical Peptide L37pA Protects against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor	9
When Autophagy Fails: ATG7 Variants and Their Impact on Radiation Lung Injury	9
Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung	9
Sex-based Immune and Genetic Mechanisms in Asthma: A Shift Toward Precision Medicine?	9
The Gut–Lung Axis: What’s below the Diaphragm Is Also Important	9
Collagen 18A1/Endostatin Expression in the Progression of Right Ventricular Remodeling and Dysfunction in Pulmonary Arterial Hypertension	9
Epigenomic Dysregulation in Youth Vapers: Implications for Disease Risk Assessment	9
Kasugamycin Is a Novel Chitinase 1 Inhibitor with Strong Antifibrotic Effects on Pulmonary Fibrosis	9
Hyaluronan is a Promising Host-Directed Therapy for Viral Pneumonia	9
A Redox-Shifted Fibroblast Subpopulation Emerges in the Fibrotic Lung	9
Does Chronic Obstructive Pulmonary Disease Originate from Different Cell Types?	9
eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis	9
Microenvironment Regulators of Metastasis Favor Lymphangioleiomyomatosis Cell Growth and Disease Progression	9
December Highlights/Papers by Junior Investigators/NIH News	8
ALCAM Makes It All Calm by Inhibiting Apoptosis	8
Chronic Kidney Disease–associated Lung Injury Is Mediated by Phosphate-induced MAPK/AKT Signaling	8
Activated Clec4n^hi Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner	8
Switching On Gene Therapy for Allergic Rhinitis: The AAVITS Approach	8
Investigation of CFTR Function in Human Nasal Epithelial Cells Informs Personalized Medicine	8
You Can’t Spell Shear without “She”: Mechanobiology and Sex Differences in Hypoxic Lung Disease	8
One More Negative Regulator of AC6: S-Nitrosylation	8
Lipids to the Rescue in Pulmonary Fibrosis: Biosynthesis, Bioenergetics, or Epigenetics?	8
Hyperoxia and Surfactant Dysfunction in Critical Illness: Insights and Future Therapeutic Prospects	8
ER Stress Disrupts the Airway Epithelium and Reduces Host Defense during Influenza A Virus Infection	8
Unveiling an Important New Cell Type in the Lung: Microfold Cells	8
Mycobacterium tuberculosis Induces Warburg Metabolism in Human Alveolar Macrophages: A Transcriptomic Analysis	8
June Highlights/Papers by Junior Investigators/NIH News	8
Single-Cell Profiling of Premature Neonate Airways Reveals a Continuum of Myeloid Differentiation	8
Opening up to cAMP Transport Mechanisms in Airway Smooth Muscle	8
Monocytes: See One Queuing Local Adaptive Immune Responses to Respiratory Viruses	8
Cell Population–resolved Multiomics Atlas of the Developing Lung	8
Peripheral Transcriptome of Severe Sarcoidosis Involves Dysregulation of Multiple Immunologic Systems	8
Bubble Trouble: Epithelial Extracellular Vesicles and Their microRNA Mischief in Chronic Obstructive Pulmonary Disease	8
Goblet Cells Signaling to the Alveolar Niche: Macrophages Are the Link	8
From Splicing Landscape to Therapeutic Targets: Long-Read Sequencing in Non-Small-Cell Lung Cancer	8
Cystic Fibrosis: “Ionocyte Modulators”?	7
“It’s a Trap”: Eosinophils Caught between Pro- and Anti-inflammatory Responses	7
The Potential of Extracellular Microvesicle MicroRNAs in Precapillary Pulmonary Hypertension	7
Identification of a Fraction of Cross-Reactive Th2 Cells in Patients with Allergic Asthma	7
Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human Lungs	7
Reply to Fujino et al.: Human Lung Cell Separation Strategies for Translational Research	7
Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet–Neutrophil Interactions	7
Respiratory Epithelial Cell Surface Decoration Provides Defense against Bacterial Damage during Infection	7
A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis	7
Ventilator-induced Lung Injury Promotes Inflammation within the Pleural Cavity	7
Can ENaC “TIP” the Scales to Reduce Endothelial Reactive Oxygen Species and Vascular Leak during Pneumococcal Lung Injury?	7
A Functional Variant rs2122031 in ATG7 Is Associated with the Risk of Radiation Pneumonitis	7
Reclaiming the Balance: Blocking Glutamine Uptake to Restrain Pulmonary Fibrosis	7
Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Emphysema	7
Characteristics and Regulation of Human Eosinophil ETosis In Vitro	7
Suppression of Allergic Asthma by Loss of Function of Miz1-mediated Th1 Skewing	7
Sectm1a Depletion Promotes Neutrophil Recruitment during Pneumococcal Pneumonia	7
Regulation of Endothelial Cell Death in Inflammatory Lung Injury	7
Trefoil Factor Family: A Troika for Lung Repair and Regeneration	7
Identification of Lymphangioleiomyomatosis-associated Serum MicroRNAs	7
May Highlights/Papers by Junior Investigators/NIH News	7
Circular RNA Methylation: A New Twist in Lung Fibrosis	7
High-Content Screening Identifies Cyclosporin A as a Novel ABCA3-Specific Molecular Corrector	7
Single Cell Omics Identify an Anti-Inflammatory Niche in Macrophages of Mild to Moderate COPD	7
Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia	7
LAM–CAM: In Vivo Model for Rapid Analysis of Lymphangioleiomyomatosis Tumor Formation and Inhibition	7
March Highlights/Papers by Junior Investigators/NIH News	7
On the Ultrastructure of Aberrant Basaloid Cells in Idiopathic Pulmonary Fibrosis	7
Engineering HMGB1-derived Peptides to Unravel Sex-Specific Mechanisms in Pulmonary Arterial Hypertension	7