American Journal of Respiratory Cell and Molecular Biology

Article	Citations
LPS Increases Artery but Not Airway Contraction in Precision Cut Lung Slices from a Mouse Model of ARDS	153
Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis	68
Functional Gene Variants in Chronic Obstructive Pulmonary Disease: The Search Continues	59
Pseudomonas aeruginosa Lipid A Structural Variants Induce Altered Immune Responses	59
Plasma Proteome Profiles Associated with Early Development of Lung Injury in Extremely Preterm Infants	51
MLKL Protects Pulmonary Endothelial Cells in Acute Lung Injury	49
Molecular Maestro in the Lung: The Sphingolipid Rheostat	46
MOTS-c Promotes Glycolysis via AMPK-HIF-1α-PFKFB3 Pathway to Ameliorate CPB-induced Lung Injury	45
New Insights Relating Gasdermin B to the Onset of Childhood Asthma	43
Extracellular Vesicle ASC: A Novel Mediator for Lung–Brain Axis in Preterm Brain Injury	41
Bronchopulmonary Dysplasia and Pulmonary Hypertension. The Role of Smooth Muscle adh5	40
Novel Hemodynamic, Vascular Lesion, and Cytokine/Chemokine Differences Regarding Sex in a Pulmonary Arterial Hypertension Model	39
Gene-ius at Work: Decoding Cell States Through Expression	37
Starving a Cell Promotes Airway Smooth Muscle Relaxation: Inhibition of Glycolysis Attenuates Excitation–Contraction Coupling	37
Sputum Metabolomic Signature and Dynamic Change of Cough Variant Asthma	37
Neuroblastoma Suppressor of Tumorigenicity 1 Mediates Endothelial-to-Mesenchymal Transition in Pulmonary Arterial Hypertension Related to Congenital Heart Disease	35
Intestinal Microbiota-derived Propionic Acid Protects against Zinc Oxide Nanoparticle–induced Lung Injury	35
The Endothelium Is in Shock and IFN-α/STAT1 Signaling Is to Blame	34
Loss of Tbx4 Affects Postnatal Lung Development and Predisposes to Pulmonary Hypertension	34
Temporal Release of IL-1 Family Members from Virally Infected Airway Epithelial Cells Suggests IL-36γ Is the Early Responder	32
Spotlighting “Neutrophil Elastase Triggers the Release of Macrophage Extracellular Traps”: A New Catch in Cystic Fibrosis?	32
Cardiac and Pulmonary Vascular Dysfunction in Vitamin D–Deficient Bmpr2-Mutant Rats	32
CXCL14 Protects against Polymicrobial Sepsis by Enhancing Antibacterial Functions of Macrophages	31
Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice	30
Long Story Short: Understanding Isoform-Specific Expression of FAM13A	30

IL-1β Induces a Proinflammatory Fibroblast Microenvironment that Impairs Lung Progenitors’ Function	30
Targeting S1PR2 in Sepsis, One Fragmented Mitochondrion at a Time	30
December Highlights/Papers by Junior Investigators/NIH News	29
September Highlights/Papers by Junior Investigators/NIH News	28
July Highlights/Papers by Junior Investigators/NIH News	28
June Highlights/Papers by Junior Investigators/NIH News	28
October Highlights/Papers by Junior Investigators/NIH News	27
ZMPSTE24 Regulates SARS-CoV-2 Spike Protein–enhanced Expression of Endothelial PAI-1	26
Exposure to Urban Air Pollution Particulate Matter Modifies Th1/Th2 Mtb Immunity in the Human Lung	26
Human Primary Airway Basal Cells Display a Continuum of Molecular Phases from Health to Disease in Chronic Obstructive Pulmonary Disease	25
The Impact of Inflammation on Thermal Hyperpnea: Relevance for Heat Stress and Febrile Seizures	25
Tartrate-Resistant Acid Phosphatase 5 (TRAP5) Promotes Eosinophil Migration During Allergic Asthma	25
Expression of ACE2—a Key SARS-CoV-2 Entry Factor—Is Not Increased in the Nasal Mucosa of People with Cystic Fibrosis	24
Prenatal FGFR2 Signaling via PI3K/AKT Specifies the PDGFRA+Myofibroblast	24
SUMO Wrestling in the Airway Epithelium: Does It Regulate Thymic Stromal Lymphopoietin?	23
First Steps toward Personalized Therapies for ABCA3 Deficiency	23
When a DEAD-Box Protein Is the Key: A Novel Role for DDX5 in Lung Pericyte Dysfunction	22
Circulating Myeloid Cell–derived Extracellular Vesicles as Mediators of Indirect Acute Lung Injury	22
A Mixed Blood-Lymphatic Endothelial Cell Phenotype in Lymphangioleiomyomatosis and Idiopathic Pulmonary Fibrosis but Not in Kaposi’s Sarcoma or Tuberous Sclerosis Complex	22
CSP7 Protects Alveolar Epithelial Cells by Targeting p53-Fibrinolytic Pathways During Lung Injuries	22
The Big Impact of Small Airway pH	21
Multiple Fibroblast Subtypes Contribute to Matrix Deposition in Pulmonary Fibrosis	21
MicroRNA Control Lipid-laden Alveolar Macrophages in Smokers: A Potential Therapeutic Target for Chronic Obstructive Pulmonary Disease?	21
Delayed Microbial Maturation Durably Exacerbates Th17-driven Asthma in Mice	21
Yield and Diversity of Human Distal Lung Epithelial Cells Isolated by Different Sorting Strategies	21
Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2	20
Enhanced Gαq Signaling in TSC2-Deficient Cells Is Required for Their Neoplastic Behavior	19
Convergent Evidence SupportsTH2LCRRas a Novel Asthma Susceptibility Gene	19
A Murine Model of Mycobacterium abscessus Infection Mimics Pathology of Chronic Human Lung Disease	19
Interstitial Macrophages Mediate Efferocytosis of Alveolar Epithelium during Influenza Infection	19
A Glowing Opportunity to Target YAP in Lung Fibrosis	18
Lysophospholipid Acyltransferase 9 Promotes Emphysema Formation via Platelet-activating Factor	18
ATP12A: Connecting Mucus and Fibrosis in Idiopathic Pulmonary Fibrosis	18
Chronic Marijuana Use Is Associated with Gene Expression Changes in BAL	18
KAT’s in the Cradle: p300/CBP and Regulation of HIF-1 and Blood Pressure during Intermittent Hypoxia	18
TRPV4 Regulates the Macrophage Metabolic Response to Limit Sepsis-induced Lung Injury	17
Akt-driven TGF-β and DKK1 Secretion Impairs F508del Cystic Fibrosis Airway Epithelium Polarity	17
The Role of Obesity in the Immunopathogenesis of COVID-19 Respiratory Disease and Critical Illness	17
Cough-Variant Asthma: The Asthma Phenotype No One Coughs About	17
When It Comes to COVID-19, Inflammation Is All the RAGE	17
Lung Interstitial Macrophages Can Present Soluble Antigens and Induce Foxp3+ Regulatory T Cells	17
Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α	17
Adenovirus-mediated Overexpression of FcγRIIB Attenuates Pulmonary Inflammation and Fibrosis	16
AKT Phosphorylates FAM13A and Promotes Its Degradation via CUL4A/DDB1/DCAF1 E3 Complex	16
LKB1 Regulates Pulmonary Hypertension Endothelial Cell Mitochondria: Another Layer of the Pulmonary Vascular Onion?	16
Loss of Pulmonary Endothelial Cells in Emphysema Impairs Support of Human Alveolar Epithelial Cell Growth	16
Whole-Genome Methylation Sequencing Reveals that COVID-19–induced Epigenetic Dysregulation Remains 1 Year after Hospital Discharge	16
SARS-CoV-2 Infection Is Associated with Reduced Krüppel-like Factor 2 in Human Lung Autopsy	16
Achieving Excellence and Engaging Members	16
Time Is Running Out in Pulmonary Arterial Hypertension: The Epigenetic Clock Is Clicking	16

Chronic Alcohol Intake Compromises Lung Immunity by Altering Immunometabolism in Humans and Mouse Models	15
Soluble E-Cadherin Contributes to Airway Inflammation in Severe Asthma	15
Dysregulation of Pyruvate Kinase M2 Promotes Inflammation in a Mouse Model of Obese Allergic Asthma	15
2022-2023 Journal Award Winners	15
Improving Mitochondrial Function in Viral Infection: Targeting Cellular Metabolism	15
Role of KCNK3 Dysfunction in Dasatinib-associated Pulmonary Arterial Hypertension and Endothelial Cell Dysfunction	15
The Homeobox Transcription Factor CUX1 Coordinates Postnatal Epithelial Developmental Timing but Is Dispensable for Lung Organogenesis and Regeneration	15
A Locus on Chromosome 15 Contributes to Acute Ozone-induced Lung Injury in Collaborative Cross Mice	15
Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1 Pathway during Acute Respiratory Syncytial Virus Infection	15
Axl Mediates Resistance to Respiratory Syncytial Virus Infection Independent of Cell Attachment	14
A Single-Cell RNA Sequencing Atlas of the Chronic Obstructive Pulmonary Disease Distal Lung to Predict Cell–Cell Communication	14
Peripheral Blood Omics and Other Multiplex-based Systems in Pulmonary and Critical Care Medicine	14
Prorelaxant E-type Prostanoid Receptors Functionally Partition to Different Procontractile Receptors in Airway Smooth Muscle	14
Acidic Enough for a Healthy Breath	14
Oxidized Phosphatidylcholines Trigger TRPA1 and Ryanodine Receptor–dependent Airway Smooth Muscle Contraction	14
Cell Culture Differentiation and Proliferation Conditions Influence the In Vitro Regeneration of the Human Airway Epithelium	14
Scavenger Receptor BI Attenuates IL-17A–Dependent Neutrophilic Inflammation in Asthma	14
Fighting the Fiber: Targeting Collagen in Lung Fibrosis	14
Intermediary Role of Lung Alveolar Type 1 Cells in Epithelial Repair upon Sendai Virus Infection	14
A Unique CD27-IgD- B Cell Population in the Sputum of Severe Eosinophilic Asthma Associated with Airway Autoimmunity	14
Leptin Induces Epigenetic Regulation of Transient Receptor Potential Melastatin 7 in Rat Adrenal Pheochromocytoma Cells	13
Loss of cAbl Tyrosine Kinase in Pulmonary Arterial Hypertension Causes Dysfunction of Vascular Endothelial Cells	13
Calcium-Sensing Receptor Negative Allosteric Modulators Oppose Contraction of Mouse Airways	13
Searching for an Animal Model with Clinical Features of Scleroderma	13
TMPRSS11E-dward Scissorhands? Proteolysis Potentiates Lung Inflammation during Pathogen Insult	13
April Highlights/Papers by Junior Investigators/NIH News	13
Demystifying Bitter Taste Receptor Relaxation of Airway Smooth Muscle	13
Unveiling Organ Failure in the Critically Ill: Insights through the Metabolite Lens	13
Pirfenidone Mitigates TGF-β-induced Inflammation Following Virus Infection	13
Loss of Iron Regulatory Protein 2 (IRP2) Protects Mice from Lung Inflammation during Bronchoconstriction	13
Mitochondria-derived Vesicle Packaging as a Novel Therapeutic Mechanism in Pulmonary Hypertension	13
Plk1 Regulates Caspase-9 Phosphorylation at Ser-196 and Apoptosis of Human Airway Smooth Muscle Cells	13
Biomarkers of Fibrosis in Patients with COVID-19 One Year After Hospital Discharge: A Prospective Cohort Study	13
Comparison of Droplet- and Microwell-based Methods to Analyze Cryopreserved Human Bronchoalveolar Lavage Cells by scRNA-Sequencing	12
Loss of ANT1 Increases Fibrosis and Epithelial Cell Senescence in Idiopathic Pulmonary Fibrosis	12
Therapeutic Potential of Sodium Houttuyfonate in Pulmonary Hypertension through Orai-Ca2+ Channels	12
Hepatocyte HIF-1 and Intermittent Hypoxia Independently Impact Liver Fibrosis in Murine Nonalcoholic Fatty Liver Disease	12
Prenatal LPS Exposure Promotes Allergic Airway Inflammation via Long Coding RNA NONMMUT033452.2, and Protein Binding Partner, Eef1D	12
Liponucleotides: Promises and Unknowns as Novel Therapeutics for Acute Respiratory Distress Syndrome	12
Alpha-1 Antitrypsin Deficiency: Does Increased Neutrophil Adhesion Contribute to Lung Damage?	12
Alveolar and Bone Marrow–derived Macrophages Differ in Metabolism and Glutamine Utilization	12
Redox-Dependent Activation of Lung Epithelial STAT3 Is Required for Inducible Protection against Bacterial Pneumonia	12
Sodium Houttuyfonate Alleviates Monocrotaline-induced Pulmonary Hypertension by Regulating Orai1 and Orai2	11
January Highlights/Papers by Junior Investigators/NIH News	11
Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity	11
SOX17 Prevents Endothelial–Mesenchymal Transition of Pulmonary Arterial Endothelial Cells in Pulmonary Hypertension through Mediating TGF-β/Smad2/3 Signaling	11
Recessive Mutations in CFAP74 Cause Primary Ciliary Dyskinesia with Normal Ciliary Ultrastructure	11
Airway Immune Signatures in Severe and Fatal Infection with COVID-19	11
Does “Skippy” Wheeze? Evidence of Airway Remodeling in the Australian Kangaroo	11
February Highlights/Papers by Junior Investigators/NIH News	11
Human Airway Basal Cells Undergo Reversible Squamous Differentiation and Reshape Innate Immunity	11
HPS6 Deficiency Leads to Reduced Vacuolar-Type H+-ATPase and Impaired Biogenesis of Lamellar Bodies in Alveolar Type II Cells	11
Food for Thought: The Emerging Role of Intestinal Microbiota in Pulmonary Arterial Hypertension	11
Leveraging Microbial Symbiosis to Modulate Bronchopulmonary Dysplasia	11
Tipping the Balance of Ubiquitination toward a Therapy for COVID-19	11
Reuse of Cell Culture Inserts for In Vitro Human Primary Airway Epithelial Cell Studies	11
Drivers of Type 2 Inflammation in Allergic Airway Disease: Wnt You Like to Know?	11
Induced Pluripotent Stem Cell-derived Alveolar Type II Heterogeneity: Revealed by SFTPC Expression	10
A NEAT Discovery Hints at Altered Golgi Signaling in Lung Fibrosis	10
A New Methodology for the Oxygen Measurement in Lung Tissue of an Aged Ferret Model Proves Hypoxia during COVID-19	10
DNA–Protein Kinase Catalytic Subunit as a Potential Target for Pulmonary Arterial Hypertension	10
HDAC6: A Neglected Player in Chronic Obstructive Pulmonary Disease?	10
Thioredoxin Prevents Loss of UCP2 in Hyperoxia via MKK4–p38 MAPK–PGC1α Signaling and Limits Oxygen Toxicity	10
Asporin Promotes TGF-β–induced Lung Myofibroblast Differentiation by Facilitating Rab11-Dependent Recycling of TβRI	10
Pulmonary Microvascular Endothelial Cells Support Alveolar Epithelial Growth via Bone Morphogenetic Protein 6 Secretion	10
A Novel Role for γδ T Cells in Protection Against Severe Melioidosis	10
Pulmonary and Nonpulmonary Sepsis Differentially Modulate Lung Immunity toward Secondary Bacterial Pneumonia: A Critical Role for Alveolar Macrophages	10
Cell Surface RNA Expression Modulates Alveolar Epithelial Function	10
COPD Airway Epithelial Cell-derived Extracellular Vesicles Spread Cellular Senescence via MicroRNA-34a	10
The Gut–Lung Axis: What’s below the Diaphragm Is Also Important	9
Breath Markers of Oxidative Stress in Children with Severe Viral Lower Respiratory Tract Infection	9
When Autophagy Fails: ATG7 Variants and Their Impact on Radiation Lung Injury	9
Epigenomic Dysregulation in Youth Vapers: Implications for Disease Risk Assessment	9
Preventable ATII Proliferation after Hyperoxia: The “Tempo” of Folate Metabolism in the Neonatal Lung	9
Spatially Resolved Identification of Transglutaminase Substrates by Proteomics in Pulmonary Fibrosis	9
The RIPK3 Scaffold Regulates Lung Inflammation During Pseudomonas Aeruginosa Pneumonia	9
A Redox-Shifted Fibroblast Subpopulation Emerges in the Fibrotic Lung	9
Cytokine Regulation by Alpha-1 Antitrypsin Therapy: A Pathway Analysis of a Pilot Clinical Trial	9
Dual Pigment Epithelium-derived Factor and Hepatocyte Growth Factor Overexpression: A New Therapy for Pulmonary Hypertension	9
Multiresolution 3D Optical Mapping of Immune Cell Infiltrates in Mouse Asthmatic Lung	9

Alveolar Epithelial Cell Dysfunction in Idiopathic Pulmonary Fibrosis Linked to Lipid Alterations: Therapeutic Implications	9
September Highlights/Papers by Junior Investigators/NIH News	9
Does Chronic Obstructive Pulmonary Disease Originate from Different Cell Types?	9
July Highlights/Papers by Junior Investigators/NIH News	9
Impaired Differentiation of Chronic Obstructive Pulmonary Disease Bronchial Epithelial Cells Grown on Bronchial Scaffolds	9
Targeting the AXL Receptor in Combating Smoking-related Pulmonary Fibrosis	9
eNAMPT Is a Novel Damage-associated Molecular Pattern Protein That Contributes to the Severity of Radiation-induced Lung Fibrosis	9
Activated Clec4nhi Neutrophils Aggravate Lung Injury in an Endothelial IGFBP7-Dependent Manner	8
Postexposure Liponucleotide Prophylaxis and Treatment Attenuates Acute Respiratory Distress Syndrome in Influenza-infected Mice	8
Amphipathic Helical Peptide L37pA Protects against Lung Vascular Endothelial Dysfunction Caused by Truncated Oxidized Phospholipids via Antagonism with CD36 Receptor	8
Opening up to cAMP Transport Mechanisms in Airway Smooth Muscle	8
June Highlights/Papers by Junior Investigators/NIH News	8
Collagen 18A1/Endostatin Expression in the Progression of Right Ventricular Remodeling and Dysfunction in Pulmonary Arterial Hypertension	8
ALCAM Makes It All Calm by Inhibiting Apoptosis	8
Mycobacterium tuberculosis Induces Warburg Metabolism in Human Alveolar Macrophages: A Transcriptomic Analysis	8
Peripheral Transcriptome of Severe Sarcoidosis Involves Dysregulation of Multiple Immunologic Systems	8
Monocytes: See One Queuing Local Adaptive Immune Responses to Respiratory Viruses	8
Investigation of CFTR Function in Human Nasal Epithelial Cells Informs Personalized Medicine	8
Lipids to the Rescue in Pulmonary Fibrosis: Biosynthesis, Bioenergetics, or Epigenetics?	8
Microenvironment Regulators of Metastasis Favor Lymphangioleiomyomatosis Cell Growth and Disease Progression	8
Airway Administration of Flagellin Regulates the Inflammatory Response to Pseudomonas aeruginosa	8
Suppression of Allergic Asthma by Loss of Function of Miz1-mediated Th1 Skewing	8
Enhanced Lyn Activity Causes Severe, Progressive Emphysema and Lung Cancer	8
Unveiling an Important New Cell Type in the Lung: Microfold Cells	8
Chronic Kidney Disease–associated Lung Injury Is Mediated by Phosphate-induced MAPK/AKT Signaling	8
Bubble Trouble: Epithelial Extracellular Vesicles and Their microRNA Mischief in COPD	8
Single-Cell Profiling of Premature Neonate Airways Reveals a Continuum of Myeloid Differentiation	8
Trefoil Factor Family: A Troika for Lung Repair and Regeneration	8
Kasugamycin Is a Novel Chitinase 1 Inhibitor with Strong Antifibrotic Effects on Pulmonary Fibrosis	8
Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p	8
Cell Population–resolved Multiomics Atlas of the Developing Lung	8
Molecular Signatures of Idiopathic Pulmonary Fibrosis	8
Characteristics and Regulation of Human Eosinophil ETosis In Vitro	7
Reply to Fujino et al.: Human Lung Cell Separation Strategies for Translational Research	7
Sectm1a Depletion Promotes Neutrophil Recruitment during Pneumococcal Pneumonia	7
High-Content Screening Identifies Cyclosporin A as a Novel ABCA3-Specific Molecular Corrector	7
Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human Lungs	7
Efficient Transduction of Alveolar Type 2 Cells with Adeno-associated Virus for the Study of Lung Regeneration	7
Can ENaC “TIP” the Scales to Reduce Endothelial Reactive Oxygen Species and Vascular Leak during Pneumococcal Lung Injury?	7
Cystic Fibrosis: “Ionocyte Modulators”?	7
Fetal Tracheal Occlusion Correlates with Normalized YAP Expression and Alveolar Epithelial Differentiation in Congenital Diaphragmatic Hernia	7
A Single-Cell Atlas of Large and Small Airways at Birth in a Porcine Model of Cystic Fibrosis	7
March Highlights/Papers by Junior Investigators/NIH News	7
Respiratory Epithelial Cell Surface Decoration Provides Defense against Bacterial Damage during Infection	7
December Highlights/Papers by Junior Investigators/NIH News	7
Increased Circulating Extracellular Superoxide Dismutase Attenuates Platelet–Neutrophil Interactions	7
Efficient Adeno-associated Virus–mediated Transgenesis in Alveolar Stem Cells and Associated Niches	7
May Highlights/Papers by Junior Investigators/NIH News	7
Circular RNA Methylation: A New Twist in Lung Fibrosis	7
Identification of a Fraction of Cross-Reactive Th2 Cells in Patients with Allergic Asthma	7
Engineering HMGB1-Derived Peptides to Unravel Sex-Specific Mechanisms in Pulmonary Arterial Hypertension	7
On the Ultrastructure of Aberrant Basaloid Cells in Idiopathic Pulmonary Fibrosis	7
One More Negative Regulator of AC6: S-Nitrosylation	7
You Can’t Spell Shear without “She”: Mechanobiology and Sex Differences in Hypoxic Lung Disease	7
Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Emphysema	7
Overexpression of Decay Accelerating Factor Mitigates Fibrotic Responses to Lung Injury	7
“It’s a Trap”: Eosinophils Caught between Pro- and Anti-inflammatory Responses	7
A Functional Variant rs2122031 in ATG7 Is Associated with the Risk of Radiation Pneumonitis	7
Ventilator-induced Lung Injury Promotes Inflammation within the Pleural Cavity	7