Seminars in Cancer Biology

Article	Citations
Remodeling of tumor microenvironment by cellular senescence and immunosenescence in cervical cancer	384
Mechanisms and strategies of immunosenescence effects on non-small cell lung cancer (NSCLC) treatment: A comprehensive analysis and future directions	329
Insights into the role of gut and intratumor microbiota in pancreatic ductal adenocarcinoma as new key players in preventive, diagnostic and therapeutic perspective	263
The role of transcription factors in the acquisition of the four latest proposed hallmarks of cancer and corresponding enabling characteristics	243
Extracellular vesicles proteins for early cancer diagnosis: From omics to biomarkers	220
Recent advances in microbial toxin-related strategies to combat cancer	215
Alternative splicing in EMT and TGF-β signaling during cancer progression	193
New opportunities and challenges of venom-based and bacteria-derived molecules for anticancer targeted therapy	183
Extracellular matrix proteins in metastases to the liver – Composition, function and potential applications	178
Microbiome dysbiosis in cancer: Exploring therapeutic strategies to counter the disease	173
Breast cancer heterogeneity through the lens of single-cell analysis and spatial pathologies	169
Comparative analysis of the minimal information for studies of extracellular vesicles guidelines: Advancements and implications for extracellular vesicle research	164
Can integrative biomarker approaches improve prediction of platinum and PARP inhibitor response in ovarian cancer?	162
PROTAC as a novel anti-cancer strategy by targeting aging-related signaling	162
Precision medicine in myeloid malignancies	161
Small secretory proteins of immune cells can modulate gynecological cancers	160
Chemokines network in bone metastasis: Vital regulators of seeding and soiling	155
Role of cholesterol metabolism in the anticancer pharmacology of selective estrogen receptor modulators	152
Possible connection between diet and microRNA in cancer scenario	149
Role of non-coding RNAs in the progression and resistance of cutaneous malignancies and autoimmune diseases	146
Nuclear receptors: Lipid and hormone sensors with essential roles in the control of cancer development	145
Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy	138
Insights into the role of complement regulatory proteins in HPV mediated cervical carcinogenesis	135
The HECT family of E3 ubiquitin ligases and PTEN	133
Contributions of the distinct biophysical phenotype of polyploidal giant cancer cells to cancer progression	128

Sex dimorphism in the tumor microenvironment – From bench to bedside and back	126
The role of RNA-binding proteins in the processing of mRNAs produced by carcinogenic papillomaviruses	126
A comprehensive review of the multifaceted role of the microbiota in human pancreatic carcinoma	126
Extracellular vesicles as source for the identification of minimally invasive molecular signatures in glioblastoma	122
Combining radiation therapy with immune checkpoint blockade for the treatment of small cell lung cancer	120
Editorial Board	116
Editorial Board	113
Editorial Board	111
Editorial Board	107
Aberrant transcription factors in the cancers of the pancreas	107
Twenty-third Heidelberger Symposium on cancer research	106
Editorial Board	105
Editorial Board	104
Editorial Board	102
Editorial Board	102
Advances in biology and novel treatments of SCLC	101
Brain macrophage senescence in glioma	101
Editorial Board	101
Tumor-derived nanoseeds condition the soil for metastatic organotropism	100
Stem-loop binding protein and metal carcinogenesis	100
Dietary molecules and experimental evidence of epigenetic influence in cancer chemoprevention: An insight	100
Deregulated transcription factors in the emerging cancer hallmarks	98
The complex network of transcription factors, immune checkpoint inhibitors and stemness features in colorectal cancer: A recent update	98
Inflammation-targeted nanomedicine against brain cancer: From design strategies to future developments	98
What we know on the potential use of exosomes for nanodelivery	94
99mTC-sestamibi breast imaging: Current status, new ideas and future perspectives	94
Biology of cancer: Understanding the supracellular control of mitosis in physiological processes and malignancy	93
Transcriptional factors targeting in cancer stem cells for tumor modulation	92
Precision diagnostics in lymphomas – Recent developments and future directions	92
Harmonization after the GDPR? Divergences in the rules for genetic and health data sharing in four member states and ways to overcome them by EU measures: Insights from Germany, Greece, Latvia and Swe	91
Understanding and targeting prostate cancer cell heterogeneity and plasticity	90
Obesity and multiple myeloma: Emerging mechanisms and perspectives	90
Targeting Hippo signaling pathway by phytochemicals in cancer therapy	90
HDL and cancer - causality still needs to be confirmed? Update 2020	88
Revisiting antibody-drug conjugates and their predictive biomarkers in platinum-resistant ovarian cancer	86
Critical DNA damaging pathways in tumorigenesis	86
Biology of cancer; from cellular and molecular mechanisms to developmental processes and adaptation	86
Therapy-induced shaping of the glioblastoma microenvironment: Macrophages at play	86
Obesity and main urologic cancers: Current systematic evidence, novel biological mechanisms, perspectives and challenges	85
Nanomedicine for urologic cancers: diagnosis and management	84
Apolipoprotein mimetics in cancer	83
Arsenic-induced epigenetic changes in cancer development	82
Deep computational pathology in breast cancer	82
Understanding the cross-talk between human microbiota and gastrointestinal cancer for developing potential diagnostic and prognostic biomarkers	81
Putting the brakes on tumorigenesis with snake venom toxins: New molecular insights for cancer drug discovery	80
Genomic profiling of platinum-resistant ovarian cancer: The road into druggable targets	80
Combined targeting of senescent cells and senescent macrophages: A new idea for integrated treatment of lung cancer	80
Dysregulations of long non-coding RNAs − The emerging “lnc” in environmental carcinogenesis	80
Extracellular vesicles in cancer pros and cons: The importance of the evidence-based medicine	79
Profiling of extracellular vesicles in oral cancer, from transcriptomics to proteomics	78

Immune evasion on the nanoscale: Small extracellular vesicles in pancreatic ductal adenocarcinoma immunity	78
Next-generation diagnostics for precision oncology: Preanalytical considerations, technical challenges, and available technologies	77
Targeting intratumoral hypoxia to enhance anti-tumor immunity	76
Non-coding RNA biomarkers in pancreatic ductal adenocarcinoma	75
cGAS/STING signalling pathway in senescence and oncogenesis	74
Obesity associated pancreatic ductal adenocarcinoma: Therapeutic challenges	74
Dissecting the heritable risk of breast cancer: From statistical methods to susceptibility genes	71
The IGF2BP family of RNA binding proteins links epitranscriptomics to cancer	70
Application of artificial intelligence for improving early detection and prediction of therapeutic outcomes for gastric cancer in the era of precision oncology	70
Polyploid giant cancer cells: An emerging new field of cancer biology	69
An updated overview on metal nanoparticles toxicity	68
Microbes in lung cancer initiation, treatment, and outcome: Boon or bane?	67
Role of endolysosome function in iron metabolism and brain carcinogenesis	67
Integrated imaging and molecular analysis to decipher tumor microenvironment in the era of immunotherapy	66
DNMT1: A key drug target in triple-negative breast cancer	65
RNA-binding proteins: Underestimated contributors in tumorigenesis	64
Curcumin: A therapeutic strategy for colorectal cancer?	63
Exosomes and extracellular vesicles: Rethinking the essential values in cancer biology	62
Gut microbiota and immunosenescence in cancer	62
Inside the stemness engine: Mechanistic links between deregulated transcription factors and stemness in cancer	62
The Relationship of the Microbiome, Associated Metabolites and the Gut Barrier with Pancreatic Cancer	61
Slow-cycling (dormant) cancer cells in therapy resistance, cancer relapse and metastasis	60
Dietary fat, bile acid metabolism and colorectal cancer	60
Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities	60
Liver regeneration and liver metastasis	60
Carbonic anhydrase IX: A tumor acidification switch in heterogeneity and chemokine regulation	59
Multifaceted role of chemokines in solid tumors: From biology to therapy	59
The molecular chaperone TRAP1 in cancer: From the basics of biology to pharmacological targeting	59
Breast cancer metastasis to bone: From epithelial to mesenchymal transition to breast osteoblast-like cells	59
Checkpoint: Inspecting the barriers in glioblastoma immunotherapies	58
RNA regulatory mechanisms controlling TGF-β signaling and EMT in cancer	58
Effects of tyrosine kinase inhibitors on thyroid function and thyroid hormone metabolism	58
Updated review on green tea polyphenol epigallocatechin-3-gallate as a cancer epigenetic regulator	57
The intricate nature of senescence in development and cell plasticity	57
Mitochondrial mutations and mitoepigenetics: Focus on regulation of oxidative stress-induced responses in breast cancers	57
The Warburg effect: the hacked mitochondrial-nuclear communication in cancer	57
Role of iron in cancer	57
RNA-binding proteins and cancer metastasis	57
Historical perspective of tumor glycolysis: A century with Otto Warburg	56
Epigenetic modifications of c-MYC: Role in cancer cell reprogramming, progression and chemoresistance	56
Artificial intelligence aids in development of nanomedicines for cancer management	54
Emerging applications of bacteria as antitumor agents	54
Connections between endoplasmic reticulum stress-associated unfolded protein response, mitochondria, and autophagy in arsenic-induced carcinogenesis	54
Artificial intelligence in cancer immunotherapy: Applications in neoantigen recognition, antibody design and immunotherapy response prediction	53
Unveiling the role of PIK3R1 in cancer: A comprehensive review of regulatory signaling and therapeutic implications	53
Emerging role of pancreatic stellate cell-derived extracellular vesicles in pancreatic cancer	53
Extracellular vesicles in cancer progression	52
The evolutionary legacy of immune checkpoint inhibitors	51
Inflammation targeted nanomedicines: Patents and applications in cancer therapy	51
Precision cancer medicine: What has translated into clinical use in Belgium?	51
Small cell lung cancer: Subtypes and therapeutic implications	51
Aberrant protein synthesis and cancer development: The role of canonical eukaryotic initiation, elongation and termination factors in tumorigenesis	51
Artificial intelligence-based prediction of clinical outcome in immunotherapy and targeted therapy of lung cancer	51
Innovative trial design in precision oncology	50
Precision medicine in pediatric solid cancers	50
Nutrition and upper gastrointestinal cancers: An overview of current understandings	50
Gut microbes in gastrointestinal cancers	50
Interplay of ferroptosis, cuproptosis, and PANoptosis in cancer treatment-induced cardiotoxicity: Mechanisms and therapeutic implications	50
T-cell-based breast cancer immunotherapy	50
Green nanoparticles as multifunctional nanomedicines: Insights into anti-inflammatory effects, growth signaling and apoptosis mechanism in cancer	50
Multifaceted effects of obesity on cancer immunotherapies: Bridging preclinical models and clinical data	49
Exploiting transcription factors to target EMT and cancer stem cells for tumor modulation and therapy	49
Nano-targeting vascular remodeling in cancer: Recent developments and future directions	49
CDK inhibitors from past to present: A new wave of cancer therapy	48
Editorial Board	48
Editorial Board	48
Editorial Board	48
The interplay of obesity, gut microbiome and diet in the immune check point inhibitors therapy era	48
Nanomedicines: Targeting inflammatory pathway in cancer and aging	48
Special issue: Therapy-induced remodeling of the tumor microenvironment	48
Editorial Board	48
Editorial Board	48
Editorial Board	48
Editorial Board	48
Special issue Microbes in Cancer Research in 'Seminar in Cancer Biology' 2021	47
Excess body weight and postmenopausal breast cancer: Emerging molecular mechanisms and perspectives	47
Editorial Board	47
The role of autophagy in metal-induced urogenital carcinogenesis	47
Special issue: Deregulated transcription factors in the cancer therapeutic challenges: An update on cancer stemness features	47
Evolution of small cell lung cancer tumor mutation: from molecular mechanisms to novel viewpoints	47

Pro-tumoral functions of tumor-associated macrophage EV-miRNA	47
Targeting CSC-related transcription factors by E3 ubiquitin ligases for cancer therapy	46
Emerging role of microbiota in immunomodulation and cancer immunotherapy	46
Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs	46
Genetics and Genomics of Breast Cancer: update and translational perspectives	46
Editorial: Role of chemokines in tumor heterogeneity	46
Diverse roles of EV-RNA in cancer progression	46
Can medical imaging identify the histopathological growth patterns of liver metastases?	46
One label is all you need: Interpretable AI-enhanced histopathology for oncology	46
Corrigendum to “How far have we explored fungi to fight cancer?” [86/Part 2 (2022) 976–989]	46
Post-translational regulations of PD-L1 and PD-1: Mechanisms and opportunities for combined immunotherapy	46
Artificial intelligence in oncology: From bench to clinic	45
Disseminated cancer cells in breast cancer: Mechanism of dissemination and dormancy and emerging insights on therapeutic opportunities	45
Clinical application of AI-based PET images in oncological patients	45
The second half of mitosis and its implications in cancer biology	45
Targeting micro-environmental pathways by PROTACs as a therapeutic strategy	44
Epigenetic remodelling under hypoxia	44
Immune senescence: A key player in cancer biology	44
Genomic profiling of sporadic liver metastatic colorectal cancer	43
Immune-modulating and anti-inflammatory marine compounds against cancer	43
Association of Chlamydia and Mycoplasma infections with susceptibility to ovarian cancer: A systematic review and meta-analysis	43
Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications	43
Artificial intelligence-assisted selection and efficacy prediction of antineoplastic strategies for precision cancer therapy	43
Therapy-induced polyploidization and senescence: Coincidence or interconnection?	43
Regulatory effects of noncoding RNAs on the interplay of oxidative stress and autophagy in cancer malignancy and therapy	43
PIWI-interacting RNAs in human cancer	43
Targeting oncogenic transcription factors in skin malignancies: An update on cancer stemness and therapeutic outcomes	42
The role of surgery in platinum-resistant ovarian cancer: A call to the scientific community	42
Polyploidy formation in cancer cells: How a Trojan horse is born	41
Anticancer properties of chimeric HDAC and kinase inhibitors	41
Microbiome dysbiosis and epigenetic modulations in lung cancer: From pathogenesis to therapy	41
Predicting liver metastases growth patterns: Current status and future possibilities	41
The role of exercise in obesity-related cancers: Current evidence and biological mechanisms	41
miRNAs mediated drug resistance in hematological malignancies	41