Genes Chromosomes & Cancer

Article	Citations
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Uncovering variable neoplasms between ATM protein‐truncating and common missense variants using 394 694 UK Biobank exomes	47
Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck	46
Polymorphisms of the PD‐L1 gene 3′‐untranslated region are associated with the expression of PD‐L1 in non‐small cell lung cancer	40
IGH::IL3‐Rearranged B‐Cell Precursor Acute Lymphoblastic Leukemia With Hypereosinophilia in a Child With a Novel PAX5 Germline Variant	35
Insertion of the CXXC domain of KMT2A into YAP1: An unusual mechanism behind the formation of a chimeric oncogenic protein	28
Neonatal osteoblastic tumor with a novel PTBP1::FOSB fusion	28
MDM4 amplification in atypical lipomatous tumors/well‐differentiated liposarcoma: Private event or alternative oncogenic mechanism?	26
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ERG amplification is a secondary recurrent driver event in myeloid malignancy with complex karyotype and TP53 mutations	22
An SS18::NEDD4 cutaneous spindled and epithelioid sarcoma: An hitherto unclassified cutaneous sarcoma, resembling epithelioid sarcoma with aggressive clinical behavior	22
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ERRATUM	19
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Correction to “Temporal Trends and Regional Variability in BRAF and KRAS Genetic Testing in Denmark (2010–2022): Implications for Precision Medicine”	18
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Comprehensive Analyses of Somatic Copy Number Alterations and Mutations Based on the Adenoma–Carcinoma Sequence	18
The somatic p.T81dup variant in AKT3 gene underlies a mild cerebral phenotype and expands the spectrum including capillary malformation and lateralized overgrowth	17
Uterine Myxoid Mesenchymal Tumor With a Novel SS18::VEZF1 Gene Fusion, Lacking Worrisome Histological Features	17
Fusion‐positive non‐small cell lung carcinoma: Biological principles, clinical practice, and diagnostic implications	16
Near complete remission of an inoperable pancreatic acinar cell carcinoma after BRAF‐/MEK‐inhibitor treatment—A case report and review of the literature	16
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Acute megakaryoblastic leukemia with trisomy 3 and CBFA2T3::GLIS2: A case report	15

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Ewing sarcoma and related FET family translocation‐associated round cell tumors: A century of clinical and scientific progress	15
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Malignant peripheral nerve sheath tumor in children: A clinicopathologic and molecular study with parallels to the adult counterpart	15
Malignant Bone‐Forming Neoplasm With NIPBL::BEND2 Fusion	14
Genomic profile analysis of leiomyomas with bizarre nuclei and fumarate hydratase deficient leiomyomas: Strengths, weaknesses, and limitations of array‐CGH interpretation	13
ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma	13
Epithelioid hemangioendothelioma (EHE) with WWTR1::TFE3 gene fusion, a novel fusion variant	13
VIM::KMT2A‐rearranged sarcomas: A report of two new cases confirming an entity with distinct histologic features	13
Constitutional balanced translocations involving SMARCB1: A rare cause of rhabdoid tumor predisposition syndrome	12
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Clear cell mesotheliomas with inactivating VHL mutations and near‐haploid genomic features	12
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EWSR1::SSX1 Fusion‐Driven Synovial Sarcoma: A Case Presentation and Review of the Literature	12
Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma	11
Low‐Level BCR::ABL1 Transcript at Diagnosis in Childhood Leukemia: A 10‐Year Single Institution Study	11
A Clinicopathologic and Molecular Reappraisal of Myxoinflammatory Fibroblastic Sarcoma—A Controversial and Pathologically Challenging Low‐Grade Sarcoma	11
Untying the Gordian knot of composite hemangioendothelioma: Discovery of novel fusions	11
The presence of a chromosomal abnormality in cytopenia without dysplasia identifies a category of high‐risk clonal cytopenia of unknown significance	11
Expanding the spectrum of mesenchymal neoplasms with NR1D1‐rearrangement	11
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Digital pathology systems enabling quality patient care	10
Whole genome duplication in oral squamous cell carcinoma in patients younger than 50 years: implications for prognosis and adverse clinicopathological factors	10
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3′RNA and whole‐genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1	10
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Structural Variant Analysis of Complex Karyotype Myelodysplastic Neoplasia Through Optical Genome Mapping	10
IDH‐negative chondrosarcoma with metachronous dedifferentiation only in the metastatic site—A diagnostic pitfall	9
Fibromyxoid aSoft Tissue Tumor With PLAG1 Fusion—The First Case in an Adult Patient	9
Spindle Cell Rhabdomyosarcoma of the Prostate With ZFP64::NCOA2 Fusion	9
The Variable Genomic Landscape During Osteosarcoma Progression: Insights From a Longitudinal WGS Analysis	9
A cloud‐based resource for genome coordinate‐based exploration and large‐scale analysis of chromosome aberrations and gene fusions in cancer	9
Molecular investigation of ALK‐rearranged epithelioid fibrous histiocytomas identifies CLTC as a novel fusion partner and evidence of fusion‐independent transcripti	9
RREB1::MRTFB fusion‐positive extra‐glossal mesenchymal neoplasms: A series of five cases expanding their anatomic distribution and highlighting significant morphological and phenotypic diversit	8
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Tyrosine kinase‐altered spindle cell neoplasms with EGFR internal tandem duplications	8
Identification of a novel SH3PXD2B::FER fusion in a case of plexiform myofibroblastic tumor and review of the literature	8
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A case of a lipoblastoma with EEF1A1::PLAG1 fusion and metaplastic ossification	8
MicroRNA Expression in High‐Grade B‐Cell Lymphoma With 11q Aberration	8
A Bibliometric Analysis on the Risk Factors of Cancer	8
Issue Information	8
Gene amplification in neoplasia: A cytogenetic survey of 80 131 cases	8
Refined cytogenetic IPSS‐R evaluation by the use of SNP array in a cohort of 290 MDS patients	7
PMS2 or PMS2CL? Characterization of variants detected in the 3′ of the PMS2 gene	7
Rhabdomyosarcoma With EWSR1::NF2 Gene Fusion: A Case Report Potentially Expanding Its Genetic Spectrum	7

NovelHNRNPM::LEUTXfusion resulting from chromothripsis of chromosome 19 in a pediatric undifferentiated small round cell neoplasm	7
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Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T‐ALL: Focus on miR‐363‐3p and promoter methylation	7
Identification of Rare EIF3E::RSPO2 Fusion in Recurrent and Aggressive Urachal Adenocarcinoma	7
Prevalence and Reclassification of Genetic Variants in South African Populations with Breast Cancer	7
Influence of Cytogenetics on the Outcome of Patients With High‐Risk Myelodysplastic Syndrome Including Deletion 5q Treated With Azacitidine With or Without Lenalidomide	7
POU2AF3‐rearranged sarcomas: A novel tumor defined by fusions of EWSR1 or FUS to a gene formerly designated COLCA2	7
How to use AI in pathology	7
PLAG1‐Rearranged Fibromyxoid and Lipomatous Neoplasms in Children and Adults: Separate Entities or a Morphological Spectrum?	7
Issue Information	7
Central nervous system sarcoma with ATXN1::DUX4 fusion expands the concept of CIC‐rearranged sarcoma	7
Recurrent PTBP1::MAML2 fusions in composite hemangioendothelioma with neuroendocrine differentiation: A report of two cases involving neck lymph nodes	7
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Adult Type Lipoblastoma With a Predominantly Fibroblastic Morphology and a Novel DLEU2::PLAG1 Gene Rearrangement: Two Cases of a Rare Entity	7
A novel IRF2BP2::CDX2 Gene fusion in digital intravascular myoepithelioma of soft tissue: An enigma!	7
Nanopore DNA Sequencing Detected Chromothripsis‐Induced PAFAH1B1::USP6 Rearrangement in Periosteal Solid Aneurysmal Bone Cyst Initially Diagnosed as Osteosarcoma	7
Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case‐based review	6
Adolescent presentation of FGFR1::EBF2 gene fusion mesenchymal tumor	6
Novel ACTB::FER Promoter Swap Fusion Characterizes Rare Superficial Myoid/Myofibroblastic Tumors	6
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ALK‐rearranged Mesenchymal Neoplasms: A Report of 9 cases Further Expanding the Clinicopathologic Spectrum of Emerging Kinase Fusion Positive Group of Tumors	6
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Durable Response to Pazopanib (Tyrosine Kinase Inhibitor) in a Patient With EWSR1::CREM Gene Fusion Positive Intra‐Abdominal Unclassified Epithelioid Sar	6
GLI1, CDK4, and MDM2 Co‐Amplification Gastric Plexiform Fibromyxoma: A Case Report and Literature Review	6
Secondary Genetic Alterations in Extraskeletal Myxoid Chondrosarcoma	6
Susanne M. Gollin, PhD, Sept 22, 1953–April 6, 2025	6
Uncovering the WWTR1::NCOA2 Gene fusion in low‐grade myoepithelial‐rich neoplasm with HMGA2 expression: A case report	6
TAF15::NR4A3 gene fusion identifies a morphologically distinct subset of extraskeletal myxoid chondrosarcoma mimicking myoepithelial tumors	6
FIP1L1::PDGFRA Fusion in a Pediatric Patient Presenting With B‐Cell Lymphoblastic Leukemia	6
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Alternative genetic alterations of MYC, BCL2, and/or BCL6 in high‐grade B‐cell lymphoma (HGBL) and diffuse large B‐cell lymphoma (DLBCL): Can we identify dif	6
Survey of germline variants in cancer‐associated genes in young adults with colorectal cancer	6
Cell Senescence and the Genetics of Melanoma Development	5
Corrigendum	5
Gene fusions in gastrointestinal tract cancers	5
Complete mimicry: Rhabdomyosarcoma with FUS::TFCP2 fusion masquerading as carcinoma—diagnostic challenge and report of two cases	5
Germline variation in RASAL2 may predict survival in patients with RAS‐activated colorectal cancer	5
Issue Information	5
Corrigendum	5
Sporadic Breast Angiosarcoma With MYC Amplification on Extrachromosomal Circular DNA Detected Using Nanopore Sequencing in an Adolescent Female	5
Soft‐tissue sarcoma with MN1‐BEND2 fusion: A case report and comparison with astroblastoma	5
Metastasizing aneurysmal dermatofibroma initially diagnosed as angiosarcoma confirmed by CD63::PRKCD fusion gene detection with nanopore sequencing	5
Merged testing for colorectal cancer syndromes and re‐evaluation of genetic variants improve diagnostic yield: Results from a nationwide prospective cohort	5
Calcifying Spindle Cell Soft Tissue Tumor With SOX10::PLAG1 Fusion: A Case Report of a Morphologically Distinctive and Potentially Novel Soft Tissue Tumor	5
Giemsa‐negative chromosome bands preferentially recombine in cancer‐associated translocations and gene fusions	5
Neuregulin 1 (NRG1) fusion‐positive high‐grade spindle cell sarcoma: A distinct group of soft tissue tumors with metastatic potential	5
A cutaneous epithelioid vascular tumor harboring a TPM3::ALK fusion	5
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Novel EWSR1::UBP1 fusion expands the spectrum of spindle cell rhabdomyosarcomas	5
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Malignant Peripheral Nerve Sheath Tumor (MPNST) With Smooth Muscle Differentiation of the Uterus—A Case Report With Emphasis on Diagnostic Pitfalls and Value of DNA Methylation A	5
Expanding the spectrum of GLI1‐altered mesenchymal tumors—A high‐grade uterine sarcoma harboring a novel PAMR1::GLI1 fusion and literature review of GLI1‐altered mesenchyma	4
N‐terminus DUX4‐immunohistochemistry is a reliable methodology for the diagnosis of DUX4‐fused B‐lymphoblastic leukemia/lymphoma (N‐terminus DUX4 IHC for DUX4<	4
MYH9::LTK Fusion in a Pediatric Acral Soft Tissue Spindle Cell Neoplasm	4
Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia	4
A case of spindle cell rhabdomyosarcoma with a ZFP64::NCOA3 fusion	4
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Microsatellite Instability and Loss of Heterozygosity as Prognostic Markers in Oral Squamous Cell Carcinoma: Molecular Mechanisms, Detection Techniques, and Therapeutic Strategies	4
Novel HMGA2::COL14A1 Fusion Identified in Xanthogranulomatous Epithelial Tumor/Keratin‐Positive Giant Cell Tumor	4
A Novel JAK2 Fusion in T‐Cell Prolymphocytic Leukemia	4
GAB1::ABL1 fusions define a distinctive soft tissue neoplasm, with variable perineurial differentiation, and a predilection for children and young adults	4
Clinicopathologic and survival correlates of embryonal rhabdomyosarcoma driven by RAS/RAF mutations	4
FGFR1 gene fusions in a subset of pediatric mesenchymal tumors: Expanding the genetic spectrum of tumors sharing histologic overlap with infantile fibrosarcoma and “NTRK<	4
Spindle cell neoplasms with novel LTK fusion – Expanding the spectrum of kinase fusion‐positive soft tissue tumors	4
Correction to “EWSR1::SSX1 Fusion‐Driven Synovial Sarcoma: A Case Presentation and Review of the Literature”	4
Distinct Signatures of Chromosomal Involvement in 59 251 Translocations Across 58 Tumor Types. A Novel Perspective	4
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EWSR1 Rearrangements in Basaloid Neoplasms With Adnexal Differentiation	4
TFG::MET‐rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low‐grade triphasic morphology	4
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TFE3‐Altered Perivascular Epithelioid Cell Tumour (PEComa) of the Nasal Cavity With a Novel TRAF3::TFE3 Fusion—A Report of a Case Expanding the Molecular Genetic Spectrum and	4
Successful treatment with MEK‐inhibitor in a patient with NRAS‐related cutaneous skeletal hypophosphatemia syndrome	4
A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia	4
The clinicopathologic significance of NPM1 mutation and ability to detect mutated NPM1 by immunohistochemistry in non‐AML myeloid neoplasms	4
A Challenging Case of an Intraosseous Composite Hemangioendothelioma of the Occipital Bone With YAP1::FOXR1 Fusion	4
Wholistic approach: Transcriptomic analysis and beyond using archival material for molecular diagnosis	4
Osteoblastoma of the thumb with a novel PRSS44::ALK fusion and literature review of osteoblastoma of hands and feet bones	4
DICER1‐mutated rhabdomyosarcoma of the ovary with teratoid features	3
Changes on chromosome 11p15.5 as specific marker for embryonal rhabdomyosarcoma?	3
Mismatch repair deficiency: The what, how and why it is important	3

Pseudoglandular Schwannoma With FUS::KLF17 Fusion: Broadening the Spectrum of FUS‐Associated Tumors	3
Issue Information	3
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Development and validation of blood tumor mutational burden reference standards	3
Shallow whole‐genome sequencing of bone marrow aspirates in myelodysplastic neoplasms: A retrospective comparison with cytogenetics	3
BCOR‐Mutated Conventional and Dedifferentiated Chondrosarcoma: A Clinicopathologic Study	3
Discovery of Cis‐Regulatory Mechanisms via Non‐Coding Mutations in Acute Lymphoblastic Leukemia	3
Erratum	3
Single‐Cell Profiling of Mononuclear Cells Identifies Transcriptomics Signatures Differentiating Prostate Cancer From Benign Prostatic Hyperplasia	3
Corrigendum	3
Vanished MDM2 amplification in multiple recurrences of an irradiated poorly differentiated sarcoma with amplified TRIO::TERT fusion gene	3
Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13)	3
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Genomic profiling of pleomorphic rhabdomyosarcoma reveals a genomic signature distinct from that of embryonal rhabdomyosarcoma	3
FGFR2::TACC2 fusion as a novel KIT‐independent mechanism of targeted therapy failure in a multidrug‐resistant gastrointestinal stromal tumor	3
Hereditary Colorectal Cancer and Polyposis Syndromes Caused by Variants in Uncommon Genes	2
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Molecular Classification of Resected Primary Duodenal Adenocarcinoma	2
Methylation classifiers: Brain tumors, sarcomas, and what's next	2
A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias	2
A novel STRN3::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland with high‐grade transformation	2
Comprehensive analyses of microRNA and mRNA expression in colorectal serrated lesions and colorectal cancer with a microsatellite instability phenotype	2
A case of FN1‐fused calcified chondroid mesenchymal neoplasm of the hand with novel FGFR3 partner gene	2
ANNOUNCEMENT	2
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COL1A1::PDGFB fusion uterine sarcoma with a TERT promoter mutation	2
Translocation carcinomas of the kidney	2
Macroscopic Monozygotic Androgenetic/Biparental Mosaicism: Molecular Characterization and Clinical Implications	2
Schwann Cells Deficient in Neurofibromin Lack Sensitivity to Their Biomechanical Microenvironment	2
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Malignant undifferentiated epithelioid neoplasms with MAML2 rearrangements: A clinicopathologic study of seven cases demonstrating a heterogenous entity	2
A novel colony‐stimulating factor 1 (CSF1) translocation  involving human endogenous retroviral element in a tenosynovial giant cell tumor	2
Gene Expression Profiles of AHNAK2, DCSTAMP, FN1, and TERT Correlate With Mutational Status and Recurrence in Papillary Thyroid Carcinoma	2
A novel HMGA2::KITLG fusion in a dedifferentiated liposarcoma with amplification of MDM2 and HMGA2	2
Clonal origin and genomic diversity in Lynch syndrome‐associated endometrial cancer with multiple synchronous tumors: Identification of the pathogenicity of MLH1 p.L582H	2
Novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and aggressive presentation	2
Spindle Cell Sarcoma With Novel JAZF1::NUDT5 Gene Fusion: Report of a Previously Undescribed Neoplasm	2
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Complementary value of molecular analysis to expert review in refining classification of uncommon soft tissue tumors	2
An Inflammatory Myofibroblastic Tumor With a Novel ALKV1180L Mutation Leading to Acquired Resistance to Tyrosine Kinase Inhibitors	2
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Typical, atypical and cryptic t(15;17)(q24;q21) (PML::RARA) observed in acute promyelocytic leukemia: A retrospective review of 831 patients with concurrent chromosome and PML::RARA dual	2
When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion	2
NR1D1::MAML1 epithelioid and spindle cell sarcoma mimicking pseudomyogenic hemangioendothelioma in core biopsy: A case report and review of the literature	2
Primary mediastinal large B‐cell lymphoma is characterized by large‐scale copy‐neutral loss of heterozygosity	2
Pediatric Erythroid Sarcoma Diagnostically Confirmed by Identification of a Recurrent NFIA::CBFA2T3 Fusion	1
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Related mechanisms, current treatments, and new perspectives in meningioma	1
Rethinking cancer initiation: The role of large‐scale mutational events	1
Segregation, immunohistochemical, molecular and functional analyses classify a novel missense variant in fumarate hydratase (FH) as pathogenic	1
Standardizing analysis of intra‐tumoral heterogeneity with computational pathology	1
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Novel SMARCA2 :: DDIT3	1
Constitutional and acquired genetic variants in ARID5B in pediatric B‐cell precursor acute lymphoblastic leukemia	1
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Challenging Conventional Perceptions of Oncogenes and Tumor Suppressor Genes: A Comprehensive Analysis of Gene Expression Patterns in Cancer	1
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YAP1::KMT2A‐Rearranged Sarcoma: Report of a New Case With Unusual Morphology and Immunohistochemical Features	1
The Transcriptomic and Gene Fusion Landscape of Pleomorphic Salivary Gland Adenomas	1
An intraosseous myoepithelial carcinoma with a EWSR1::PBX3 fusion	1
Colibactin mutational signatures in NTHL1 tumor syndrome and MUTYH associated polyposis patients	1
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Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture‐Based Gene Panel	1
Profiling Precursor microRNAs of Breast Cancer From Total RNA Sequencing Data to Gain Insights Into Their Roles and Prognostic Values	1
17p13 (TP53) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas	1
Novel PDGFRB Gene Fusions in Two Cases of Infantile Myofibromatosis	1
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High‐Grade Uterine Sarcoma: First Report of a MEIS2::FOXO4 Fusion	1
Pediatric Mesenchymal Tumor With MN1::TAF3 Fusion	1
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Transcriptomic profiles‐based approach to decode the role of miR‐122 in triple negative breast cancer	1
Comparative DNA Methylation Profiling of Human and Murine ALK‐Positive B‐Cell Neoplasms	1
Clinicopathological features and resistance mechanisms in HIP1‐ALK‐rearranged lung cancer: A multicenter study	1
Widening the Spectrum of Fusion Events in Schwannoma: Identification of a Novel TANC1::HTRA1 Fusion	1
Pediatric Fibromatosis Lacks the Internal Tandem Duplication of EGFR Seen in Congenital Mesoblastic Nephroma	1
Clinicopathologic and molecular correlates to neoadjuvant chemotherapy‐induced pathologic response in breast angiosarcoma	1
The novel finding of an FGFR1::TACC1 fusion in an undifferentiated spindle cell sarcoma of soft tissue with aggressive clinical course	1
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