Genes Chromosomes & Cancer

Article	Citations
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MDM4 amplification in atypical lipomatous tumors/well‐differentiated liposarcoma: Private event or alternative oncogenic mechanism?	49
ERG amplification is a secondary recurrent driver event in myeloid malignancy with complex karyotype and TP53 mutations	42
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IGH::IL3‐Rearranged B‐Cell Precursor Acute Lymphoblastic Leukemia With Hypereosinophilia in a Child With a Novel PAX5 Germline Variant	30
Neonatal osteoblastic tumor with a novel PTBP1::FOSB fusion	29
Insertion of the CXXC domain of KMT2A into YAP1: An unusual mechanism behind the formation of a chimeric oncogenic protein	24
Uncovering variable neoplasms between ATM protein‐truncating and common missense variants using 394 694 UK Biobank exomes	23
An SS18::NEDD4 cutaneous spindled and epithelioid sarcoma: An hitherto unclassified cutaneous sarcoma, resembling epithelioid sarcoma with aggressive clinical behavior	22
The Role of RB1 and Secondary Genomic Changes in the Development of Spindle Cell and Pleomorphic Lipomas	21
Recurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck	20
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Polymorphisms of the PD‐L1 gene 3′‐untranslated region are associated with the expression of PD‐L1 in non‐small cell lung cancer	19
ERRATUM	18
Comprehensive Analyses of Somatic Copy Number Alterations and Mutations Based on the Adenoma–Carcinoma Sequence	18
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Correction to “Temporal Trends and Regional Variability in BRAF and KRAS Genetic Testing in Denmark (2010–2022): Implications for Precision Medicine”	17
Uterine Myxoid Mesenchymal Tumor With a Novel SS18::VEZF1 Gene Fusion, Lacking Worrisome Histological Features	16
Fusion‐positive non‐small cell lung carcinoma: Biological principles, clinical practice, and diagnostic implications	16
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Near complete remission of an inoperable pancreatic acinar cell carcinoma after BRAF‐/MEK‐inhibitor treatment—A case report and review of the literature	16
Ewing sarcoma and related FET family translocation‐associated round cell tumors: A century of clinical and scientific progress	15
Malignant peripheral nerve sheath tumor in children: A clinicopathologic and molecular study with parallels to the adult counterpart	15

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The somatic p.T81dup variant in AKT3 gene underlies a mild cerebral phenotype and expands the spectrum including capillary malformation and lateralized overgrowth	15
Acute megakaryoblastic leukemia with trisomy 3 and CBFA2T3::GLIS2: A case report	14
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VIM::KMT2A‐rearranged sarcomas: A report of two new cases confirming an entity with distinct histologic features	13
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Epithelioid hemangioendothelioma (EHE) with WWTR1::TFE3 gene fusion, a novel fusion variant	13
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Genomic profile analysis of leiomyomas with bizarre nuclei and fumarate hydratase deficient leiomyomas: Strengths, weaknesses, and limitations of array‐CGH interpretation	12
GLI1 ‐Altered Mesenchymal Tumor of the Duodenum With a Novel TNFAIP3::GLI1	12
EWSR1::SSX1 Fusion‐Driven Synovial Sarcoma: A Case Presentation and Review of the Literature	12
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Malignant Bone‐Forming Neoplasm With NIPBL::BEND2 Fusion	12
ZFP64::NCOA3 gene fusion defines a novel subset of spindle cell rhabdomyosarcoma	12
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Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma	11
Constitutional balanced translocations involving SMARCB1: A rare cause of rhabdoid tumor predisposition syndrome	11
Clear cell mesotheliomas with inactivating VHL mutations and near‐haploid genomic features	11
Digital pathology systems enabling quality patient care	10
A Clinicopathologic and Molecular Reappraisal of Myxoinflammatory Fibroblastic Sarcoma—A Controversial and Pathologically Challenging Low‐Grade Sarcoma	10
3′RNA and whole‐genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1	10
Untying the Gordian knot of composite hemangioendothelioma: Discovery of novel fusions	10
Structural Variant Analysis of Complex Karyotype Myelodysplastic Neoplasia Through Optical Genome Mapping	10
The presence of a chromosomal abnormality in cytopenia without dysplasia identifies a category of high‐risk clonal cytopenia of unknown significance	10
Expanding the Morphologic and Molecular Spectrum of Spindle Cell Tumors Associated With TERT Fusions	10
Novel Resistance Mechanisms to Second‐Generation EGFR Tyrosine Kinase Inhibitor Afatinib and Associations With Genomic Features in	10
Expanding the spectrum of mesenchymal neoplasms with NR1D1‐rearrangement	10
Low‐Level BCR::ABL1 Transcript at Diagnosis in Childhood Leukemia: A 10‐Year Single Institution Study	10
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A cloud‐based resource for genome coordinate‐based exploration and large‐scale analysis of chromosome aberrations and gene fusions in cancer	9
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Spindle Cell Rhabdomyosarcoma of the Prostate With ZFP64::NCOA2 Fusion	8
Identification of a novel SH3PXD2B::FER fusion in a case of plexiform myofibroblastic tumor and review of the literature	8
IDH‐negative chondrosarcoma with metachronous dedifferentiation only in the metastatic site—A diagnostic pitfall	8
The Variable Genomic Landscape During Osteosarcoma Progression: Insights From a Longitudinal WGS Analysis	8
Molecular investigation of ALK‐rearranged epithelioid fibrous histiocytomas identifies CLTC as a novel fusion partner and evidence of fusion‐independent transcripti	8
Clinical and Pathologic Description of Three Aneurysmal Bone Cyst Cases With Novel USP6 Fusion Partners Including SEC24D	8
RREB1::MRTFB fusion‐positive extra‐glossal mesenchymal neoplasms: A series of five cases expanding their anatomic distribution and highlighting significant morphological and phenotypic diversit	8
Fibromyxoid aSoft Tissue Tumor With PLAG1 Fusion—The First Case in an Adult Patient	8
A Bibliometric Analysis on the Risk Factors of Cancer	8
Influence of Cytogenetics on the Outcome of Patients With High‐Risk Myelodysplastic Syndrome Including Deletion 5q Treated With Azacitidine With or Without Lenalidomide	7
Gene amplification in neoplasia: A cytogenetic survey of 80 131 cases	7
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Resurfacing Threats: Metastatic Ossifying Fibromyxoid Tumor Emerging After Almost Two Decades	7
MicroRNA Expression in High‐Grade B‐Cell Lymphoma With 11q Aberration	7
Multiomics to investigate the mechanisms contributing to repression of PTPRC and SOCS2 in pediatric T‐ALL: Focus on miR‐363‐3p and promoter methylation	7
Refined cytogenetic IPSS‐R evaluation by the use of SNP array in a cohort of 290 MDS patients	7

Tyrosine kinase‐altered spindle cell neoplasms with EGFR internal tandem duplications	7
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Prevalence and Reclassification of Genetic Variants in South African Populations with Breast Cancer	7
Identification of Rare EIF3E::RSPO2 Fusion in Recurrent and Aggressive Urachal Adenocarcinoma	7
Nanopore DNA Sequencing Detected Chromothripsis‐Induced PAFAH1B1::USP6 Rearrangement in Periosteal Solid Aneurysmal Bone Cyst Initially Diagnosed as Osteosarcoma	7
PMS2 or PMS2CL? Characterization of variants detected in the 3′ of the PMS2 gene	7
Whole genome duplication in oral squamous cell carcinoma in patients younger than 50 years: implications for prognosis and adverse clinicopathological factors	7
A case of a lipoblastoma with EEF1A1::PLAG1 fusion and metaplastic ossification	7
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Central nervous system sarcoma with ATXN1::DUX4 fusion expands the concept of CIC‐rearranged sarcoma	7
Rhabdomyosarcoma With EWSR1::NF2 Gene Fusion: A Case Report Potentially Expanding Its Genetic Spectrum	7
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Adult Type Lipoblastoma With a Predominantly Fibroblastic Morphology and a Novel DLEU2::PLAG1 Gene Rearrangement: Two Cases of a Rare Entity	6
A novel IRF2BP2::CDX2 Gene fusion in digital intravascular myoepithelioma of soft tissue: An enigma!	6
“Benign” Metastasizing Fibrous Histiocytoma Harboring PRKCD Gene Fusions With Malignant Clinical Course	6
Novel ACTB::FER Promoter Swap Fusion Characterizes Rare Superficial Myoid/Myofibroblastic Tumors	6
How to use AI in pathology	6
NovelHNRNPM::LEUTXfusion resulting from chromothripsis of chromosome 19 in a pediatric undifferentiated small round cell neoplasm	6
POU2AF3‐rearranged sarcomas: A novel tumor defined by fusions of EWSR1 or FUS to a gene formerly designated COLCA2	6
Durable Response to Pazopanib (Tyrosine Kinase Inhibitor) in a Patient With EWSR1::CREM Gene Fusion Positive Intra‐Abdominal Unclassified Epithelioid Sar	6
Infantile metastatic ependymoma with a novel molecular profile and favorable outcome to intensive chemotherapy without irradiation: Case‐based review	6
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TAF15::NR4A3 gene fusion identifies a morphologically distinct subset of extraskeletal myxoid chondrosarcoma mimicking myoepithelial tumors	6
GLI1, CDK4, and MDM2 Co‐Amplification Gastric Plexiform Fibromyxoma: A Case Report and Literature Review	6
Adolescent presentation of FGFR1::EBF2 gene fusion mesenchymal tumor	6
Giemsa‐negative chromosome bands preferentially recombine in cancer‐associated translocations and gene fusions	5
Spatial Dynamics of Tumor Cell Plasticity in Lung Adenocarcinoma Revealed by Region‐Specific Single Cell Transcriptomics	5
Alternative genetic alterations of MYC, BCL2, and/or BCL6 in high‐grade B‐cell lymphoma (HGBL) and diffuse large B‐cell lymphoma (DLBCL): Can we identify dif	5
Secondary Genetic Alterations in Extraskeletal Myxoid Chondrosarcoma	5
Susanne M. Gollin, PhD, Sept 22, 1953–April 6, 2025	5
Malignant Peripheral Nerve Sheath Tumor (MPNST) With Smooth Muscle Differentiation of the Uterus—A Case Report With Emphasis on Diagnostic Pitfalls and Value of DNA Methylation A	5
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Calcifying Spindle Cell Soft Tissue Tumor With SOX10::PLAG1 Fusion: A Case Report of a Morphologically Distinctive and Potentially Novel Soft Tissue Tumor	5
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ALK‐rearranged Mesenchymal Neoplasms: A Report of 9 cases Further Expanding the Clinicopathologic Spectrum of Emerging Kinase Fusion Positive Group of Tumors	5
FIP1L1::PDGFRA Fusion in a Pediatric Patient Presenting With B‐Cell Lymphoblastic Leukemia	5
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Germline variation in RASAL2 may predict survival in patients with RAS‐activated colorectal cancer	5
Increased MYB alternative promoter usage is associated with relapse in acute lymphoblastic leukemia	5
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Cell Senescence and the Genetics of Melanoma Development	5
Merged testing for colorectal cancer syndromes and re‐evaluation of genetic variants improve diagnostic yield: Results from a nationwide prospective cohort	5
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Uncovering the WWTR1::NCOA2 Gene fusion in low‐grade myoepithelial‐rich neoplasm with HMGA2 expression: A case report	5
PLAG1‐Rearranged Fibromyxoid and Lipomatous Neoplasms in Children and Adults: Separate Entities or a Morphological Spectrum?	5
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Complete mimicry: Rhabdomyosarcoma with FUS::TFCP2 fusion masquerading as carcinoma—diagnostic challenge and report of two cases	5
Corrigendum	5
A novel HNRNPH1::ERG rearrangement in aggressive acute myeloid leukemia	4
Osteoblastoma of the thumb with a novel PRSS44::ALK fusion and literature review of osteoblastoma of hands and feet bones	4
Wholistic approach: Transcriptomic analysis and beyond using archival material for molecular diagnosis	4
A Novel JAK2 Fusion in T‐Cell Prolymphocytic Leukemia	4
MYH9::LTK Fusion in a Pediatric Acral Soft Tissue Spindle Cell Neoplasm	4
Gene fusions in gastrointestinal tract cancers	4
Metastasizing aneurysmal dermatofibroma initially diagnosed as angiosarcoma confirmed by CD63::PRKCD fusion gene detection with nanopore sequencing	4
GAB1::ABL1 fusions define a distinctive soft tissue neoplasm, with variable perineurial differentiation, and a predilection for children and young adults	4
The clinicopathologic significance of NPM1 mutation and ability to detect mutated NPM1 by immunohistochemistry in non‐AML myeloid neoplasms	4
EWSR1 Rearrangements in Basaloid Neoplasms With Adnexal Differentiation	4
Novel HMGA2::COL14A1 Fusion Identified in Xanthogranulomatous Epithelial Tumor/Keratin‐Positive Giant Cell Tumor	4
Expanding the spectrum of GLI1‐altered mesenchymal tumors—A high‐grade uterine sarcoma harboring a novel PAMR1::GLI1 fusion and literature review of GLI1‐altered mesenchyma	4
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TFE3‐Altered Perivascular Epithelioid Cell Tumour (PEComa) of the Nasal Cavity With a Novel TRAF3::TFE3 Fusion—A Report of a Case Expanding the Molecular Genetic Spectrum and	4
Successful treatment with MEK‐inhibitor in a patient with NRAS‐related cutaneous skeletal hypophosphatemia syndrome	4
Sporadic Breast Angiosarcoma With MYC Amplification on Extrachromosomal Circular DNA Detected Using Nanopore Sequencing in an Adolescent Female	4
N‐terminus DUX4‐immunohistochemistry is a reliable methodology for the diagnosis of DUX4‐fused B‐lymphoblastic leukemia/lymphoma (N‐terminus DUX4 IHC for DUX4<	4
Correction to “EWSR1::SSX1 Fusion‐Driven Synovial Sarcoma: A Case Presentation and Review of the Literature”	4
TFG::MET‐rearranged soft tissue tumor: A rare infantile neoplasm with a distinct low‐grade triphasic morphology	4
A case of spindle cell rhabdomyosarcoma with a ZFP64::NCOA3 fusion	4
Spindle cell neoplasms with novel LTK fusion – Expanding the spectrum of kinase fusion‐positive soft tissue tumors	4
FGFR1 gene fusions in a subset of pediatric mesenchymal tumors: Expanding the genetic spectrum of tumors sharing histologic overlap with infantile fibrosarcoma and “NTRK<	4
A cutaneous epithelioid vascular tumor harboring a TPM3::ALK fusion	4
Soft‐tissue sarcoma with MN1‐BEND2 fusion: A case report and comparison with astroblastoma	4
Changes on chromosome 11p15.5 as specific marker for embryonal rhabdomyosarcoma?	3
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Shallow whole‐genome sequencing of bone marrow aspirates in myelodysplastic neoplasms: A retrospective comparison with cytogenetics	3
Erratum	3

Discovery of Cis‐Regulatory Mechanisms via Non‐Coding Mutations in Acute Lymphoblastic Leukemia	3
DICER1‐mutated rhabdomyosarcoma of the ovary with teratoid features	3
Characterization of Pediatric Acute Myeloid Leukemia With t(7;12)(q36;p13)	3
Corrigendum	3
Distinct Signatures of Chromosomal Involvement in 59 251 Translocations Across 58 Tumor Types. A Novel Perspective	3
Vanished MDM2 amplification in multiple recurrences of an irradiated poorly differentiated sarcoma with amplified TRIO::TERT fusion gene	3
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A novel STRN3::PRKD1 fusion in a cribriform adenocarcinoma of salivary gland with high‐grade transformation	3
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BCOR‐Mutated Conventional and Dedifferentiated Chondrosarcoma: A Clinicopathologic Study	3
A Challenging Case of an Intraosseous Composite Hemangioendothelioma of the Occipital Bone With YAP1::FOXR1 Fusion	3
Development and validation of blood tumor mutational burden reference standards	3
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Pseudoglandular Schwannoma With FUS::KLF17 Fusion: Broadening the Spectrum of FUS‐Associated Tumors	3
A case of FN1‐fused calcified chondroid mesenchymal neoplasm of the hand with novel FGFR3 partner gene	3
Typical, atypical and cryptic t(15;17)(q24;q21) (PML::RARA) observed in acute promyelocytic leukemia: A retrospective review of 831 patients with concurrent chromosome and PML::RARA dual	3
Microsatellite Instability and Loss of Heterozygosity as Prognostic Markers in Oral Squamous Cell Carcinoma: Molecular Mechanisms, Detection Techniques, and Therapeutic Strategies	3
Schwann Cells Deficient in Neurofibromin Lack Sensitivity to Their Biomechanical Microenvironment	2
When molecular outsmarts morphology: Malignant ossifying fibromyxoid tumors masquerading as osteosarcomas, including a novel CREBZF::PHF1 fusion	2
ANNOUNCEMENT	2
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Genomic profiling of pleomorphic rhabdomyosarcoma reveals a genomic signature distinct from that of embryonal rhabdomyosarcoma	2
An Inflammatory Myofibroblastic Tumor With a Novel ALKV1180L Mutation Leading to Acquired Resistance to Tyrosine Kinase Inhibitors	2
Methylation classifiers: Brain tumors, sarcomas, and what's next	2
Complementary value of molecular analysis to expert review in refining classification of uncommon soft tissue tumors	2
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Gene Expression Profiles of AHNAK2, DCSTAMP, FN1, and TERT Correlate With Mutational Status and Recurrence in Papillary Thyroid Carcinoma	2
Malignant undifferentiated epithelioid neoplasms with MAML2 rearrangements: A clinicopathologic study of seven cases demonstrating a heterogenous entity	2
FGFR2::TACC2 fusion as a novel KIT‐independent mechanism of targeted therapy failure in a multidrug‐resistant gastrointestinal stromal tumor	2
NF1 Mutated Gastrointestinal Stromal Tumors With Coamplification of	2
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A novel t(X;21)(p11.4;q22.12) translocation adds to the role of BCOR and RUNX1 in myelodysplastic syndromes and acute myeloid leukemias	2
Macroscopic Monozygotic Androgenetic/Biparental Mosaicism: Molecular Characterization and Clinical Implications	2
A novel colony‐stimulating factor 1 (CSF1) translocation  involving human endogenous retroviral element in a tenosynovial giant cell tumor	2
Single‐Cell Profiling of Mononuclear Cells Identifies Transcriptomics Signatures Differentiating Prostate Cancer From Benign Prostatic Hyperplasia	2
Pediatric Fibromatosis Lacks the Internal Tandem Duplication of EGFR Seen in Congenital Mesoblastic Nephroma	1
Challenging Conventional Perceptions of Oncogenes and Tumor Suppressor Genes: A Comprehensive Analysis of Gene Expression Patterns in Cancer	1
Pediatric Erythroid Sarcoma Diagnostically Confirmed by Identification of a Recurrent NFIA::CBFA2T3 Fusion	1
YAP1::KMT2A‐Rearranged Sarcoma: Report of a New Case With Unusual Morphology and Immunohistochemical Features	1
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Primary mediastinal large B‐cell lymphoma is characterized by large‐scale copy‐neutral loss of heterozygosity	1
Related mechanisms, current treatments, and new perspectives in meningioma	1
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Clinicopathologic and molecular correlates to neoadjuvant chemotherapy‐induced pathologic response in breast angiosarcoma	1
Novel PDGFRB Gene Fusions in Two Cases of Infantile Myofibromatosis	1
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Constitutional and acquired genetic variants in ARID5B in pediatric B‐cell precursor acute lymphoblastic leukemia	1
Novel MED15::ATF1 fusion in a pediatric melanoma with spitzoid features and aggressive presentation	1
Hereditary Colorectal Cancer and Polyposis Syndromes Caused by Variants in Uncommon Genes	1
An intraosseous myoepithelial carcinoma with a EWSR1::PBX3 fusion	1
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Novel SMARCA2 :: DDIT3	1
Colibactin mutational signatures in NTHL1 tumor syndrome and MUTYH associated polyposis patients	1
A novel HMGA2::KITLG fusion in a dedifferentiated liposarcoma with amplification of MDM2 and HMGA2	1
High‐Grade Uterine Sarcoma: First Report of a MEIS2::FOXO4 Fusion	1
Precision Diagnostics in Myeloid Malignancies: Development and Validation of a National Capture‐Based Gene Panel	1
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Segregation, immunohistochemical, molecular and functional analyses classify a novel missense variant in fumarate hydratase (FH) as pathogenic	1
Profiling Precursor microRNAs of Breast Cancer From Total RNA Sequencing Data to Gain Insights Into Their Roles and Prognostic Values	1
Clonal origin and genomic diversity in Lynch syndrome‐associated endometrial cancer with multiple synchronous tumors: Identification of the pathogenicity of MLH1 p.L582H	1
Molecular Classification of Resected Primary Duodenal Adenocarcinoma	1
Comparative DNA Methylation Profiling of Human and Murine ALK‐Positive B‐Cell Neoplasms	1
Widening the Spectrum of Fusion Events in Schwannoma: Identification of a Novel TANC1::HTRA1 Fusion	1
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Pediatric Mesenchymal Tumor With MN1::TAF3 Fusion	1
Primary Sweat Gland Adenocarcinoma of the Skin With ATL2::PRKD3 Fusion: A Potential Cutaneous Analog of Cribriform Adenocarcinoma of the Salivary Glands?	1
17p13 (TP53) Deletions Are Associated With an Aggressive Phenotype but Unrelated to Patient Prognosis in Urothelial Bladder Carcinomas	1
Rethinking cancer initiation: The role of large‐scale mutational events	1
Standardizing analysis of intra‐tumoral heterogeneity with computational pathology	1
The Transcriptomic and Gene Fusion Landscape of Pleomorphic Salivary Gland Adenomas	1
Transcriptomic profiles‐based approach to decode the role of miR‐122 in triple negative breast cancer	1
The novel finding of an FGFR1::TACC1 fusion in an undifferentiated spindle cell sarcoma of soft tissue with aggressive clinical course	1
Spindle Cell Sarcoma With Novel JAZF1::NUDT5 Gene Fusion: Report of a Previously Undescribed Neoplasm	1
NR1D1::MAML1 epithelioid and spindle cell sarcoma mimicking pseudomyogenic hemangioendothelioma in core biopsy: A case report and review of the literature	1
COL1A1::PDGFB fusion uterine sarcoma with a TERT promoter mutation	1