Medicinal Chemistry Research

Papers
(The H4-Index of Medicinal Chemistry Research is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
Novel pyran derivatives as potential succinate dehydrogenase inhibitors: design, synthesis, crystal structure, biological activity, and molecular modeling84
Social environment during fear extinction alters the binding of [3H] MK-801 to N-methyl-D-aspartic acid receptors in Wistar-Kyoto and Wistar rats80
Synthesis and anti-inflammatory activity of chromone-sulfonamide derivatives as COXs/iNOS dual-target inhibitors76
Development of novel triconjugates fusing melatonin/isatin/N-acylhydrazone targeting colorectal cancer: design, synthesis, biological, and in silico ADME/Tox profiling52
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties51
A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry41
Engelheptanoxides behave as liver X receptor α agonists40
Bio-guided isolation of anti-Alzheimer’s compounds from Phyllanthus niruri and role of niruriflavone in the reversal of aluminum chloride-induced neurobehavioral and biochemical changes in an animal m39
Design & synthesis of hybrid pharmacophore of β-lactam, 1,8-naphthyridine, and secondary amines; Discover their in vitro antimicrobial, anticancer properties & DFT and ADMET prediction studies36
Synthesis and biological evaluation of xanthone derivatives as anti-cancer agents targeting topoisomerase II and DNA33
2,3-Diketopiperazine as potential scaffold to develop new anti-Chagasic agents31
Ronald T. Borchardt: a pioneer in drug discovery and development28
Role of the Caco-2 cell culture model developed in Dr. Ronald T. Borchardt’s lab in modern drug research and development: a perspective from a practitioner28
Development of novel chalcone derivatives as multifunctional agents for the treatment of Alzheimer’s disease28
Synthesis, cytotoxicity, Pan-HDAC inhibitory activity and docking study of new N-(2-aminophenyl)-2-methylquinoline-4-carboxamide and (E)-N-(2-aminophenyl)-2-styrylquinoline-4-carboxamide derivatives a28
Structural simplification and ester bond flipping lead to bis-benzodioxole derivatives as potential hypolipidemic and hepatoprotective agent27
Synthesis and evaluation of tetrahydrobenzo[cd]indole derivatives as glycogen phosphorylase inhibitors26
Correction: Anticancer therapeutic potential of silibinin: current trends, scope and relevance26
4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity25
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective25
Dual inhibition strategy addressing hyperuricemia and oxidative stress: design, biological evaluation and stability studies of febuxostat-probenecid mutual prodrug24
Design, synthesis and anti-breast cancer properties of butyric ester tethered dihydroartemisinin-isatin hybrids23
A very promising antibiofilm activity against Candida albicans from an in vitro screening for antimicrobial, antibiofilm and antiproliferative activity of new synthesized 4-cinnamamido- and 2-phenoxya22
Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic antic22
Synthesis and evaluation of 2-methylbenzothiazole derivatives as monoamine oxidase inhibitors22
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