Medicinal Chemistry Research

Article	Citations
Novel pyran derivatives as potential succinate dehydrogenase inhibitors: design, synthesis, crystal structure, biological activity, and molecular modeling	84
Social environment during fear extinction alters the binding of [3H] MK-801 to N-methyl-D-aspartic acid receptors in Wistar-Kyoto and Wistar rats	80
Synthesis and anti-inflammatory activity of chromone-sulfonamide derivatives as COXs/iNOS dual-target inhibitors	76
Development of novel triconjugates fusing melatonin/isatin/N-acylhydrazone targeting colorectal cancer: design, synthesis, biological, and in silico ADME/Tox profiling	52
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties	51
A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry	41
Engelheptanoxides behave as liver X receptor α agonists	40
Bio-guided isolation of anti-Alzheimer’s compounds from Phyllanthus niruri and role of niruriflavone in the reversal of aluminum chloride-induced neurobehavioral and biochemical changes in an animal m	39
Design & synthesis of hybrid pharmacophore of β-lactam, 1,8-naphthyridine, and secondary amines; Discover their in vitro antimicrobial, anticancer properties & DFT and ADMET prediction studies	36
Synthesis and biological evaluation of xanthone derivatives as anti-cancer agents targeting topoisomerase II and DNA	33
2,3-Diketopiperazine as potential scaffold to develop new anti-Chagasic agents	31
Ronald T. Borchardt: a pioneer in drug discovery and development	28
Role of the Caco-2 cell culture model developed in Dr. Ronald T. Borchardt’s lab in modern drug research and development: a perspective from a practitioner	28
Development of novel chalcone derivatives as multifunctional agents for the treatment of Alzheimer’s disease	28
Synthesis, cytotoxicity, Pan-HDAC inhibitory activity and docking study of new N-(2-aminophenyl)-2-methylquinoline-4-carboxamide and (E)-N-(2-aminophenyl)-2-styrylquinoline-4-carboxamide derivatives a	28
Structural simplification and ester bond flipping lead to bis-benzodioxole derivatives as potential hypolipidemic and hepatoprotective agent	27
Synthesis and evaluation of tetrahydrobenzo[cd]indole derivatives as glycogen phosphorylase inhibitors	26
Correction: Anticancer therapeutic potential of silibinin: current trends, scope and relevance	26
4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity	25
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective	25
Dual inhibition strategy addressing hyperuricemia and oxidative stress: design, biological evaluation and stability studies of febuxostat-probenecid mutual prodrug	24
Design, synthesis and anti-breast cancer properties of butyric ester tethered dihydroartemisinin-isatin hybrids	23
A very promising antibiofilm activity against Candida albicans from an in vitro screening for antimicrobial, antibiofilm and antiproliferative activity of new synthesized 4-cinnamamido- and 2-phenoxya	22
Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic antic	22
Synthesis and evaluation of 2-methylbenzothiazole derivatives as monoamine oxidase inhibitors	22

Self-assembled amphiphilic bipyridine and bisquinoline cisplatin analogues: synthesis and anticancer properties	21
Quinoxaline 1,4-di-N-oxides: a review of the importance of their structure in the development of drugs against infectious diseases and cancer	21
Novel biologically active pyridine derivatives: Synthesis, structure characterization, in vitro antimicrobial evaluation and structure-activity relationship	20
Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans	19
Bexagliflozin: a comprehensive review of a recently approved SGLT2 inhibitor for the treatment of type 2 diabetes mellitus	19
Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development	18
Design, synthesis and antitumor activity evaluation of novel benzamide HDAC inhibitors	17
Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3β,12β,25-triol derivatives as α-glucosidase and PTP1B inhibitors	17
A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy	17
Design and synthesis of indole-based elipticine analogues as topoisomerase IIβ inhibitors	17
Structural optimization and biological evaluation of quinoline/naphthalene-based glyoxalase-I inhibitors as anti-cancer candidates	17
Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment	17
Synthesis of 6-dialkylaminopyrimidine carboxamide analogues and their anti-tubercular properties	16
Synthesis of the dibenzylbutane lignan LCA derivatives and evaluation of their anti-inflammatory activities	16
2-Phenyl substituted Benzimidazole derivatives: Design, synthesis, and evaluation of their antiproliferative and antimicrobial activities	15
Ethical aspects of innovative medical and medicinal sciences	15
A review of trilaciclib, a first-in-class cyclin-dependent kinase 4/6 inhibitor, for the management of metastatic small-cell lung cancer	15
Synthesis of alkoxy-isoflavones as potential α-glucosidase inhibitors	15
The versatile NDI-based compounds: emerging anticancer and antimicrobial agents	15
Synthesis, biological evaluation, and bioinformatics analysis of indole analogs on AChE and GST activities	14
Design and synthesis of ludartin derivatives as potential anticancer agents against hepatocellular carcinoma	14
Asciminib: first FDA approved allosteric inhibitor of BCR-ABL1 for the treatment of chronic myeloid leukemia	13
Plastoquinone analogs: a potential antimicrobial lead structure intensely suppressing Staphylococcus epidermidis and Candida albicans growth	13
Synthesis, structure-activity relationship studies and evaluation of a TLR 3/8/9 agonist and its analogues	13
Synthesis and biological evaluation of novel 1,3-diphenylurea quinoxaline derivatives as potent anticancer agents	13
Synthesis and antiproliferative activity of hybrid thiosemicarbazone derivatives bearing coumarin and d-galactose moieties with EGFR inhibitory activity and molecular docking study	13
DNA sequence-specific ligands. XX. Synthesis, spectral properties, virological and biochemical studies of fluorescent dimeric trisbenzimidazoles DB3P(n)	13
Carboxamide appended quinoline moieties as potential anti-proliferative agents, apoptotic inducers and Pim-1 kinase inhibitors	13
Synthesis, structural characterization and antimycobacterial evaluation of several halogenated non-nitro benzothiazinones	13
Synthesis, in vitro and in silico enzymatic inhibition assays, and toxicity evaluations of new 4,5-diphenylimidazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors	12
Design, synthesis, and biological evaluation of 2, 4-dichlorophenoxyacetamide chalcone hybrids as potential c-Met kinase inhibitors	12
Synthesis and evaluation of mycophenolic acid derivatives as potential anti-Toxoplasma gondii agents	12
Drug repositioning of benzimidazole anthelmintics in the treatment of cryptococcosis: a review	12
Development of novel 2-acetylphenol-O-alkylhydroxyethylamine derivatives as multifunctional agents for Alzheimer’s disease treatment	12
In vitro antiproliferative activity of Parrotia persica exclusive gallotannin	12
Synthesis and antitumor activity evaluation in vitro of 4-aminoquinazoline derivatives containing 1,3,4-thiadiazole	12
Design, synthesis and biological evaluation of potent thiazolidinedione salicylic acid inhibitors against glyoxalase-I as potential anticancer agents	12
Acetylcholinesterase inhibition, molecular docking and ADME prediction studies of new dihydrofuran-piperazine hybrid compounds	12
Synthesis, cytotoxicities, and carbonic anhydrase inhibition activities of pyrazoline–benzenesulfonamide derivatives harboring phenol/polyphenol moieties	11
The emerging role of proteolysis targeting chimeras (PROTACs) in the treatment of Alzheimer’s disease	11
Synthesis of 2-oxoquinoline derivatives as dual pim and mTORC protein kinase inhibitors	11
Synthesis, characterization and biological evaluation of Bis-benzimidazolium salts and their silver(I)-N-heterocyclic carbene complexes	11
Synthesis, and docking studies of arylhydrazone compounds and evaluation of their platelet aggregation inhibitory effect and cytotoxicity	10
Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study	10
Design, synthesis, and evaluation of potential carbamate prodrugs of 5′-methylthioadenosine (MTA)	10
Tetra-substituted pyrazole analogues: synthesis, molecular docking, ADMET prediction, antioxidant and pancreatic lipase inhibitory activities	10
Design, synthesis and anticancer activity studies of novel indole derivatives as Bcl-2/Mcl-1 dual inhibitors	10
Novel potent and highly selective DDR1 inhibitors from integrated lead finding	10
Synthesis and in vitro activity of oleanolic acid derivatives against Chlamydia trachomatis and Staphylococcus aureus	10
Garcidepsidone B from Garcinia parvifolia: antimicrobial activities of the medicinal plants from East and North Kalimantan against dental caries and periodontal disease pathogen	10

Triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis, cytotoxicity and antimicrobial activity	10
Design, synthesis and biological evaluation of novel 2,4,6-trisubstituted quinazoline derivatives as potential antitumor agents	10
Design, synthesis, and biological evaluation of catalpalactone and its analogs	10
Correction to: Design, synthesis and SAR of novel sulfonylurea derivatives for the treatment of diabetes mellitus in rats	10
FTase inhibitors and cancer: prospects for use in targeted therapies	9
Discovery of cytotoxic truncated vitamin D derivatives against both bortezomib‐sensitive and bortezomib‐resistant multiple myeloma phenotypes	9
Evaluation of antibacterial, antioxidant, cytotoxic, and acetylcholinesterase inhibition activities of novel [1,4] benzoxazepines fused to heterocyclic systems with a molecular modeling study	9
Design, synthesis and antitumor activity evaluation of 4,6,7-trisubstituted quinazoline derivatives containing benzothiazole moiety	9
Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.	9
Computer-aided design, synthesis and evaluation of new SARS-CoV-2 Mpro inhibitors based on 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold	9
Novel imino-thiazoloquinoxaline derivatives against renal cell carcinoma: less radiation-damaging approach	9
Correction: Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule	9
Special issue of Medicinal Chemistry Research in honor of Dr. Nicholas A. Meanwell	9
Correction: Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserine	9
The HBV capsid modulators derived from sulfamoylbenzamides and benzamides: an overview of the progress of patents	9
Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus	9
Synthesis, urease inhibitory and anticancer evaluation of glucosamine-sulfonylurea conjugates	9
Ultra-performance liquid chromatography coupled with quadrupole high-resolution time-of-flight mass spectrometry for metabolite profiling and biological activity of Stellaria pallida (Dumort) Piré	9
Synthesis of adamantane-monoterpene conjugates with 1,3,4-thiadiazol-2(3H)-imine linker and evaluation of their inhibitory activity against TDP1	9
Antibacterial, antifungal activities and toxicity of new synthetic fatty acid salicylate esters	9
Structure activity relationship (SAR) driven design and discovery of WCK 5107 (Zidebactam): novel β-lactam enhancer, potent against multidrug-resistant gram-negative pathogens	8
Unlocking therapeutic potential: exploring indole scaffolds and their structural insights as pharmacophores in designing anti-breast cancer agents	8
Pyridazinones containing the (4-methoxyphenyl)piperazine moiety as AChE/BChE inhibitors: design, synthesis, in silico and biological evaluation	8
Structural and stereochemical determinants for hGAT3 inhibition: development of novel conformationally constrained and substituted analogs of (S)-isoserine	8
N-Benzyl, N-phenethyl and N-benzyloxybenzamide derivatives inhibit amyloid-beta (Aβ42) aggregation and mitigate Aβ42-induced neurotoxicity	8
Antimicrobial activity of some celastroloids and their derivatives	8
Monoamine oxidase inhibition by thiazole derivatives substituted with the benzenesulfonamide moiety	8
Targeting disease with benzoxazoles: a comprehensive review of recent developments	8
Increased rigidity and bioisosteric replacement in the design, synthesis and preliminary evaluation of novel, functionalized 3,3-dialkyl-γ-butyrolactones as sigma-2 ligands	8
Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria	8
Design, synthesis, and antitumor activity evaluation of carbazole derivatives with potent HDAC inhibitory activity	7
Design, synthesis, in vitro evaluation, and molecular dynamics simulation studies of novel coumarin-acetohydrazide Schiff base derivatives as urease enzyme inhibitors	7
Discovery of novel donepezil-M30D hybrids with neuroprotective properties for Alzheimer’s disease treatment	7
Diverse therapeutic potential of 3-hydroxy-4-pyranones and related compounds as kojic acid analogs	7
Dedication to Dr. Thomas Baillie in recognition of his scientific career	7
Molecular glues: enhanced protein-protein interactions and cell proteome editing	7
Identification and evaluation of natural organosulfur compounds as potential dual inhibitors of α-amylase and α-glucosidase activity: an in-silico and in-vitro approach	7
Ellagic acid (EA), a tannin was isolated from Eucalyptus citriodora leaves and its anti-inflammatory activity	7
Lewis base-catalyzed synthesis of highly functionalized spirooxindole-pyranopyrazoles and their in vitro anticancer studies	7
Discovery of structurally novel tetrahydroisoquinoline derivatives bearing NO donor as potential anti-cancer therapeutics	7
Extraction and purification, pharmacological action, synthesis and product development of salidroside: a review	7
Synthesis of hydrazine containing piperazine or benzimidazole derivatives and their potential as α-amylase inhibitors by molecular docking, inhibition kinetics and in vitro cytotoxicity activity studi	7
Recent insights into antibacterial potential of benzothiazole derivatives	7
Position switch of phenylthiazoles: novel compounds with promising anti-MRSA USA300	7
Glutathione and glutathione disulfide – their biomedical and pharmaceutical applications	7
Synthesis, anticancer evaluation and docking studies of novel adamantanyl-1,3,4-oxadiazol hybrid compounds as Aurora-A kinase inhibitors	7
A review on efficacy of phytochemicals in the treatment of trypanosomiasis	6
Inhibition of jack bean urease by amphiphilic peptides	6
Correction to: Diversifying the xanthine scaffold for potential phosphodiesterase 9A inhibitors: synthesis and validation	6
Ester tethered artemisinin-isatin hybrids: design, synthesis and anti-leukemic activity evaluation	6
Identification of novel benzoyl hydrazine derivatives as activators of neddylation pathway to inhibit the tumor progression in vitro	6
Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands	6
Development of ketoprofen-p-aminobenzoic acid co-crystal: formulation, characterization, optimization, and evaluation	6
Synthesis and antitumor activity of novel silibinin and 2,3-dehydrosilybin derivatives with carbamate groups	6
Exploring the antineoplastic potential of novel NSAID derivatives in combatting mammary tumorigenesis: a comprehensive review	6
Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy	6
Pyrrolidine-based cationic γ-peptide: a DNA-binding molecule works as a potent anti-gene agent	6
Screening of small molecule compounds targeting hnRNPA2 protein	6
New class of hybrids based on chalcone and melatonin: a promising therapeutic option for the treatment of colorectal cancer	5
Potential effect of novel thiadiazole derivatives against radiation induced inflammation with low cardiovascular risk in rats	5
A reliable and automated synthesis of 6-[18F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants	5
Effect of a hexacyclic triterpenic acid from Euscaphis japonica on the oleic acid induced HepG2 cellular model of non-alcoholic fatty liver disease	5
Mannose: a potential saccharide candidate in disease management	5
Dauricine: a review of natural observation, pharmacology, and pharmacokinetics	5
Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review	5
Design, synthesis, and biological evaluation of novel 2-acetylphenol-rivastigmine hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease	5
Glycosylated triptolide affords a potent in vivo therapeutic activity to hepatocellular carcinoma in mouse model	5
Novel antimicrobial ciprofloxacin-pyridinium quaternary ammonium salts with improved physicochemical properties and DNA gyrase inhibitory activity	5
Characterization of Allium tuberosum Rottl. peptides with dual inhibitory activities against angiotensin I converting enzyme and dipeptidyl peptidase-IV	5
Development of LC-MS/MS methods affording identification and measurement of active metabolites in rat and dog plasma after oral dosing of a penta-ethyl ester prodrug of diethylenetriamine pentaacetic	5
Strong in vitro and in vivo cytotoxic effects of two platinum(II) complexes with cryptolepine derivatives	5
Synthesis and in vitro antiproliferative evaluation of novel drimane oxepinyl triazoles from labdane diterpene sclareol	5
Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives	5
Synthesis, pharmacological and molecular docking investigations of 1,3,4-oxadiazole-5-thionyl derivatives of extracted cis-clerodane diterpenoid from Cistus monspeliensis	5
Design, synthesis and biological evaluation of aminopyrimidine derivatives bearing dihydroquinoxalinone as novel EGFRL858R/T790M kinase inhibitors against non-small-cell lung cancer	5
Microwave-assisted synthesis and evaluation of their antiproliferative, antimicrobial, activities and DNA Binding studies of (3-Methyl-7H-furo[2,3-f]chromen-2-yl)(aryl)methanones	5
Tetrahydroquinoline/4,5-dihydroisoxazole hybrids with a remarkable effect over mitochondrial bioenergetic metabolism on melanoma cell line B16F10	5
Synthesis, antibacterial evaluation and in silico study of DOTA-fluoroquinolone derivatives	5
Review: Chemical and biological features of genus Paralemnalia soft corals	5
2-substituted 4-aminoquinazoline derivatives as potential dual inhibitors of EGFR and HER2: an in silico and in vitro study	5

Structure-based discovery of new polo-like kinase 1 (PLK1) inhibitors as potential anticancer agents via docking-based comparative intermolecular contacts analysis (dbCICA)	5
Evaluation of benzoylacetonitriles as novel anti-neuroinflammatory agents	5
Synthesis of 2-amino-4H-chromenes catalyst-free via sequential Knoevenagel-Michael reaction and evaluation of biological activity in tumor cells	4
Facile access to novel furoyl-based amide retroisoster inhibitors of LuxR-regulated quorum sensing: conformation analysis and docking studies	4
Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin	4
Natural products and their derivatives as anti-flavivirus drug candidates	4
Bioassay-guided isolation and identification of anti-Alzheimer’s active compounds from Spiranthes sinensis (Pers.) Ames	4
Chemical composition and vasodilator activity of different Alpinia zerumbet leaf extracts, a potential source of bioactive flavonoids	4
Design, synthesis, and in vitro biological evaluation of novel HDAC inhibitors bearing C-1 phenyl substituted tetrahydroisoquinoline Cap moiety as anti-tumor therapeutic agents	4
Design, synthesis, and anticancer activities of 8,9-substituted Luotonin A analogs as novel topoisomerase I inhibitors	4
Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments	4
Indazole derivatives as selective inhibitors of butyrylcholinesterase with effective blood-brain-barrier permeability profile	4
Discovery and exploration of monosaccharide linked dimers of galectin-3 inhibitors to target fibrosis	4
Research progress on antidiabetic activity of apigenin derivatives	4
Evaluation of chemical constituents of Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) as adenosine A1/A2A receptor ligands	4
Pyrrolobenzodiazepines: natural sources, therapeutic uses, and future in neurological treatments	4
Synthesis, inhibition effects, molecular docking and theoretical studies as Paraoxonase 1 (PON1) inhibitors of novel 1,4-dihydropyridine substituted sulfonamide derivatives	4
Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies	4
Cyclohepta[b]pyran: an important scaffold in biologically active natural products	4
Synthesis and antiproliferative activity of 7-substituted amide estradiol derivatives	4
Synthesis and biological evaluations of novel pyrazinoic acid derivatives as anticancer agents	4
ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine	4
Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications	4
Advances in research of ursolic acid and its derivatives as potential drug candidates against various types of lung cancers	4
The past decade of Genentech experience in elucidation of novel reaction mechanisms in drug metabolism	4
2-Styrylchromones as inhibitors of α-amylase and α-glucosidase enzymes for the management of type 2 diabetes mellitus	4
From the ethnomedicinal plants in northern Indochina to the development of novel anti-cancer therapeutic agents	4
A versatile strategy for the synthesis of various lumazine peptides	4
Synthesis and antiviral property of polysulfate-grafted maleimide-based enediynes	4
Design, synthesis, molecular docking study and molecular dynamics simulation of new coumarin-pyrimidine hybrid compounds having anticancer and antidiabetic activity	4
The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements	4
α-Glucosidase and cholinesterase inhibiting potential of a series of semisynthetic nitrogen triterpenic derivatives	4
Naturally occurring organosulfur for treating metabolic disorders and infectious diseases	4
Utilizing mechanistic organic chemistry training to study drug metabolism in preclinical drug discovery/development	4
Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2	4
Exploring the latest breakthroughs in rhodesain inhibitors for African trypanosomiasis	4
Gallic acid derived diarylpropanones exhibit synergistic antibacterial activities	4
Design, synthesis and investigating the in vitro and in silico HDAC8 inhibitory activities of derivatives of [6]-shogaol and [6]-gingerol isolated from ginger (Zingiber officinale)	4
Design, synthesis and evaluation of imidazo[1,2-a]pyrazin-8(7H)-one derivatives as acetylcholinesterase inhibitors and antioxidants	4
The trimethoxyphenyl (TMP) functional group: a versatile pharmacophore	4
Synthesis and characterization of new tetrakisphosphonic acid derivatives as FPPS inhibitors and evaluation of their anti-osteoclastogenic potential for prevention of osteoporosis	4
What’s been Hapten-ing over the last 88 years?	4
Structural classification of EZH2 inhibitors and prospects for the treatment of tumor: a review	4
Recent advances in triazole-benzenesulfonamide hybrids and their biological activities	4
Enantioselectivity of pinene against Leishmania amazonensis	4
Synthesis and biological evaluation of chromone derivatives against triple-negative breast cancer cells	4
Synthesis, bacterial and fungal inhibition assay, molecular docking study of substituted isatin (N-substituted 1,2,3,4-tetra-O-acetyl-β-glucopyranosyl)thiosemicarbazones	3
Dual HDAC–BRD4 inhibitors endowed with antitumor and antihyperalgesic activity	3
Design, synthesis, and antimicrobial evaluation of novel 10-Undecenoic acid-based lipidic triazoles	3
Novel 2-[(8-hydroxyquinolin-7-yl)(phenyl)methylamino]benzoic acid analogs targeting the active site of botulinum neurotoxins: designing, synthesis, and biological evaluation	3
Clerodendrum viscosum: a critical review on phytochemistry, pharmacology, quality assurance, and safety data	3
Design, synthesis and evaluation of salicylic acid-donepezil hybrids as functional agents for the treatment of Alzheimer’s disease	3
Sulfonamide derivatives of cis-imidazolines as potent p53-MDM2/MDMX protein-protein interaction inhibitors	3
Synthesis and biological evaluation of esculetin derivatives as potential anti-HBV agents	3
Dual HDAC/BRD4 inhibitors against cancer	3
Synthesis of amide warhead containing coumarin derivatives as potential pancreatic lipase inhibitors: in silico and in vitro evaluation for obesity treatment	3
Antimicrobial action of arylsulfonamides bearing (aza)norbornane and related motifs: evaluation of new promising anti-MRSA agents	3
A review on phytochemical constituents, analytical data, and pharmacological properties of the genus Plumeria	3
Benzocaine-N-acylindoline conjugates: synthesis and antiviral activity against Coxsackievirus B3	3
Esters and amides of benzofuroxan-1-N–oxide derivatives as trypanocidal and leishmanicidal agents	3
Synthesis and in vitro antitumor activity evaluation of novel 5-cyano-6-phenyl-2,4-disubstituted-pyrimidine derivatives	3
Semi-synthesis of novel thebaine derivatives with low cytotoxicity and their antibacterial and antihemolytic properties	3
Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation	3
Synthesis, trypanocidal and cytotoxic activities of α,β-unsaturated ketones derived from eugenol and analogues	3
Uncaria-derived compounds for cancer treatment: mechanistic insights and therapeutic potential	3
Inhibition of protein kinases by proton pump inhibitors: computational screening and in vitro evaluation	3
Design, synthesis, biological evaluation and in silico studies of EGFR inhibitors based on 4-oxo-chromane scaffold targeting resistance in non-small cell lung cancer (NSCLC)	3
Pyrrolo[2,1-f][1,2,4]triazine: a promising fused heterocycle to target kinases in cancer therapy	3
Design, synthesis, and biological evaluation of new 2-(4-(methylsulfonyl)phenyl)-N-phenylimidazo[1,2-a]pyridin-3-amine as selective COX-2 inhibitors	3
Special issue in honor of Prof. Laurence H. Hurley	3
Design, synthesis, and antiproliferative activities of novel thiazolyl-pyrazole hybrid derivatives	3
Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor	3
Modulators of neurolysin: promising agents for the treatment of tumor and neurological diseases	3
Role of natural secondary metabolites as HIF-1 inhibitors in cancer therapy	3
Insights into computer-aided G-quadruplex prediction in the digital age	3
A vitamin D C/D ring-derived compound with cytotoxicity	3
Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen	3
Special issue of Medicinal Chemistry Research in honor of Professor Gary L. Grunewald	3
New tetracyclic systems integrated thienopyridine scaffold as an anti-dementia lead: in silico study and biological screening	3
Phosphoryl prodrugs: characteristics to improve drug development	3
Design, Synthesis, and biological evaluation of pyrazolo-benzothiazole derivatives as a potential therapeutic agent for the treatment of Alzheimer’s disease	3
Indazole derivatives as novel inhibitors of monoamine oxidase and D-amino acid oxidase	3
Bio-evaluation of fluoro and trifluoromethyl-substituted salicylanilides against multidrug-resistant S. aureus	3
Synthesis and analgesic potential of 4-[4–chloro-3- (trifluoromethyl)-phenyl]-4-piperidinol analogues against pain model in mice	3
Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48	3
A Click Synthesis, Molecular Docking and Biological Evaluation of 1,2,3-triazoles-benzoxazepine hybrid as potential anticancer agents	3
Integrating omics data for personalized medicine in treating psoriasis	3
Novel indanone-chalcone esters with potential anti-Alzheimer effects designed using hybridization and bioisosteric replacement approaches	3
Amide- and bis-amide-linked highly potent and broadly active antifungal agents for the treatment of invasive fungal infections- towards the discovery of pre-clinical development candidate FC12406	3
Innovation in the discovery of the HIV-1 attachment inhibitor temsavir and its phosphonooxymethyl prodrug fostemsavir	3
Candida albicans ergosterol disorders as a consequence of the new sulfone derivative action mode	3
CO prodrugs: a new scaffold of adamantane-fused norbornen-7-ones with tunable water solubility	3
Chemical and biological aspects of posaconazole as a classic antifungal agent with non-classical properties: highlighting a tetrahydrofuran-based drug toward generation of new drugs	3
Design, synthesis and antitumor activity evaluation of pyrimidine derivatives containing 4-hydroxypiperidine group	3
Correction to: Perillyl alcohol and its synthetic derivatives: the rising of a novel class of selective and potent antitumoral compounds	3