Medicinal Chemistry Research

Article	Citations
Monoamine oxidase inhibition by thiazole derivatives substituted with the benzenesulfonamide moiety	110
Computer-aided design, synthesis and evaluation of new SARS-CoV-2 Mpro inhibitors based on 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold	96
Synthesis, characterization and in vitro antitumor activity of asiatic acid derivatives	75
Synthesis and antitumor activity evaluation in vitro of 4-aminoquinazoline derivatives containing 1,3,4-thiadiazole	67
Potent α-glucosidase inhibitory activity of inoscavin A from fruiting bodies of Fulvifomes fastuosus: Mechanism of action, molecular docking and ADMET	60
Bio-guided isolation of anti-Alzheimer’s compounds from Phyllanthus niruri and role of niruriflavone in the reversal of aluminum chloride-induced neurobehavioral and biochemical changes in an animal m	52
Design, synthesis and anti-breast cancer properties of butyric ester tethered dihydroartemisinin-isatin hybrids	49
Asciminib: first FDA approved allosteric inhibitor of BCR-ABL1 for the treatment of chronic myeloid leukemia	48
Synthesis of the dibenzylbutane lignan LCA derivatives and evaluation of their anti-inflammatory activities	47
Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic antic	45
Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment	43
Structural simplification and ester bond flipping lead to bis-benzodioxole derivatives as potential hypolipidemic and hepatoprotective agent	42
Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus	38
Design, synthesis, and antitumor activity evaluation of carbazole derivatives with potent HDAC inhibitory activity	38
Novel imino-thiazoloquinoxaline derivatives against renal cell carcinoma: less radiation-damaging approach	37
Glutathione and glutathione disulfide – their biomedical and pharmaceutical applications	36
Antibacterial, antifungal activities and toxicity of new synthetic fatty acid salicylate esters	34
Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study	33
Synthesis and biological evaluation of (20S,24R)-epoxy-dammarane-3β,12β,25-triol derivatives as α-glucosidase and PTP1B inhibitors	33
Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2	32
Carbamoyl flavonoids as dual inhibitors of acetylcholinesterase and monoacylglycerol lipase: synthesis, in vitro evaluation, and computational studies	32
Screening of small molecule compounds targeting hnRNPA2 protein	32
Synthesis of tetrahydro-β-carboline analogs with N11 modifications and study of their antimalarial activities	32
Evaluation of benzoylacetonitriles as novel anti-neuroinflammatory agents	29
A versatile strategy for the synthesis of various lumazine peptides	29

Utilizing mechanistic organic chemistry training to study drug metabolism in preclinical drug discovery/development	27
Pyrrolobenzodiazepines: natural sources, therapeutic uses, and future in neurological treatments	27
Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands	26
Plant-derived pyroptosis inducers as a therapeutic strategy in drug-resistant cancers	26
Design, Synthesis, and biological evaluation of pyrazolo-benzothiazole derivatives as a potential therapeutic agent for the treatment of Alzheimer’s disease	25
Contrasting effect of different crowding agents on pseudoknot RNA stability	23
Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review	23
Semi-synthesis and cytotoxicity evaluation of pyrimidine, thiazole, and indole analogues of argentatins A–C from guayule (Parthenium argentatum) resin	23
Synthesis, inhibition effects, molecular docking and theoretical studies as Paraoxonase 1 (PON1) inhibitors of novel 1,4-dihydropyridine substituted sulfonamide derivatives	22
Enantioselectivity of pinene against Leishmania amazonensis	22
Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors	21
Synthetic studies toward a simplified eleuthoside core	20
Recent advances in triazole-benzenesulfonamide hybrids and their biological activities	20
Dual-PROTACs based on natural product derivative potassium dehydrographolide succinate: design, synthesis, and antitumor activity of a novel EGFR degrader	20
A vitamin D C/D ring-derived compound with cytotoxicity	19
α-Glucosidase inhibitory activities of aromatic compounds from the rhizomes of Alpinia galanga	19
Role of natural secondary metabolites as HIF-1 inhibitors in cancer therapy	18
Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation	18
Synthesis, bacteria activity and molecular simulation of D-galactose-conjugated thiosemicarbazones of 3-aryl-4-formylsydnones	18
Synthesis and in vitro anti-trypanosomal evaluation of quinolone hydrazide analogues	17
Novel conjugated 5-alkenyl rhodanine tethered 1,4-benzodioxane derivatives as dual-chitinases inhibitors to hinder the growth of Asian corn borer	17
Pks 13 inhibitors—a promising target for future antitubercular agents	17
Design, synthesis and evaluation of salicylic acid-donepezil hybrids as functional agents for the treatment of Alzheimer’s disease	17
A Click Synthesis, Molecular Docking and Biological Evaluation of 1,2,3-triazoles-benzoxazepine hybrid as potential anticancer agents	16
Synthesis and biological evaluation of esculetin derivatives as potential anti-HBV agents	16
Exploring thiazole-linked thioureas using alkaline phosphatase assay, biochemical evaluation, computational analysis and structure–activity relationship (SAR) studies	16
Novel indanone-chalcone esters with potential anti-Alzheimer effects designed using hybridization and bioisosteric replacement approaches	16
Molecular hybridization method for obtaining paeonol-based fibrate derivatives with potent lipid-lowering and hepatoprotective activity	16
Development of new donepezil analogs: synthesis, biological screening and in silico study rational	16
1,2,3-triazenes and 1,2,3-triazoles as antileishmanial, antitrypanosomal, and antiplasmodial agents	16
Design, synthesis and antitumor activity evaluation of 2,4,6-trisubstituted quinazoline derivatives containing piperidine moiety	16
In vitro cytotoxicity evaluation of triphenylphosphonium (TPP) conjugates of some acetylenated nucleic bases and their analogues	15
Antitumor studies on celastrol and its derivatives as RORα agonists and RORγ inhibitors based on Alphafold reverse docking strategy	15
Synthesis and biological evaluation of coumarin derivatives as anti-lung adenocarcinoma agents via induction of apoptosis and autophagy: in vitro and in vivo studies	15
Antivirulence therapy: type IV pilus as a druggable target for bacterial infections	15
Design, synthesis and evaluation of aurone and indanone derivatives as novel antitumor agents	14
Insights on synthetic strategies and structure-activity relationship of donepezil and its derivatives	14
New structural scaffold discovery via fragment-based drug design: Hydroxymethyl indazole derivatives as XOR/URAT1 dual inhibitors	14
Synthesis, antiviral evaluation, molecular docking study and cytotoxicity of 5′-phosphorylated 1,2,3-triazolyl nucleoside analogues with thymine and 6-methyl uracil moieties	14
Synthesis, characterization, and anticancer activity of syringaldehyde-derived chalcones against female cancers	14
Design and synthesis of potential fungicidal compounds derived from natural products, (-)-menthol and (-)-borneol	13
Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity	13
Designations of new biological drugs	13
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells	13
Novel 2-aminopyrimidine Schiff bases as possible GABA-AT inhibitors: molecular docking, MAOS, and pharmacological screening	13
A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies	13
Synthesis and biological evaluation of triazole alcohols containing an indole-3-methyl(phenyl)amino side chain against fluconazole-resistant Candida albicans	13
Synthesis and biological assessment of triazolo-quinazoline carbothioamide derivatives for p38 MAP kinase inhibition: in-silico and in-vitro approaches	12
Dual-target inhibitors based on brpf1: a review from medicinal chemistry perspectives	12
The metabolic fate of izencitinib, a gut-selective pan-JAK inhibitor, in humans. Identification of unusual fecal metabolites and implications for MIST evaluation	12

Synthesis and pharmacological evaluation of new disulfides linked to 1,2,4-triazole bearing urea moiety	12
Glycyrrhizin and its derivatives: an emerging secondary metabolite arsenal of Glycyrrhiza glabra	12
Antiproliferative effect, cell cycle arrest and apoptosis generation of novel 6-substituted N5-formyltetrahydropyrido[3,2-d]pyrimidine derivatives	12
Discovery of potent maternal embryonic leucine zipper kinase (MELK) inhibitors of novel chemotypes using structure-based pharmacophores	11
Polyalthia longifolia: phytochemistry, ethnomedicinal importance, nutritive value, and pharmacological activities review	11
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects	11
CYP3A4 drug metabolism considerations in pediatric pharmacotherapy	11
Discovery of novel HCV inhibitors: design, synthesis and biological activity of phthalamide derivatives	11
Synthesis, in vitro activity, and molecular docking of caffeic acid and resveratrol derivatives against Alzheimer’s disease-related enzymes	10
Structure related α-glucosidase inhibitory activity and molecular docking analyses of phenolic compounds from Paeonia suffruticosa	10
Discovery of α-methylene-γ-lactone-δ-epoxy derivatives with anti-cancer activity: synthesis, SAR study, and biological activity	10
Synthesis and effects of ginkgolides and ginkgolide B derivatives on platelet activating factor induced platelet aggregation in rabbits	10
Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents	10
Discovery of novel pterostilbene/biphenyl tethered 5-FU based conjugates targeting colorectal cancer: synthesis, cytotoxic and ADMET modeling studies	10
Assessment of the α-glucosidase and α-amylase inhibitory potential of Paliurus spina-christi Mill. and its terpenic compounds	10
Pharmacological assessment of disulfide–triazine hybrids: synthesis, enzyme inhibition, and molecular docking study	10
Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations	10
Kaempferia diterpenoids and flavonoids: an overview on phytochemistry, biosynthesis, synthesis, pharmacology, and pharmacokinetics	10
Hit-to-lead optimization of amino-carboxamide benzothiazoles as LSD1 inhibitors	9
An insight into prodrug strategy for the treatment of Alzheimer’s disease	9
Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells	9
Design, synthesis, and neuroprotective activity of salidroside-based dual inhibitors of selective monoamine oxidase B and amyloid-β aggregation	9
Synthesis of functionalized 5-(4-arylpiperazin-1-yl)-N-arylpentanamides and their evaluation as D3 receptor ligands	9
Stable isotope applications in drug development and the elucidation of mechanisms of drug metabolism	9
Lipase inhibitory activity of constituents of Physalis glutinosa and Physalis latiphysa	9
4,5-diazafenylfluorene-rhodanine conjugates promote anoikis in A375 cells via inhibiting PPAR-γ expression	9
Synthesis, theoretical investigations and biological evaluation of ibuprofen drug hybrids	9
Synthesis and inhibitory activity against enzymes responsible for Type 2 diabetes mellitus of lactose-conjugated thiosemicarbazones from substituted acetophenones	9
Sphingosine 1-phosphate receptor modulators for the treatment of inflammatory bowel disease and other immune-mediated diseases	8
The potential of chalcone derivatives as human carbonic anhydrase inhibitors in the therapy of glaucoma	8
Engelheptanoxides behave as liver X receptor α agonists	8
A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry	8
Ferrocene-based compounds: promising anticancer and antimalarial agents in modern therapeutics	8
The emerging role of proteolysis targeting chimeras (PROTACs) in the treatment of Alzheimer’s disease	8
Sesquiterpene lactones isolated from Carpesium abrotanoides L. by LC–MS combined with HSCCC inhibit liver cancer through suppression of the JAK2/STAT3 signaling pathway	8
Sulfonamide-substituted oxindoles as inhibitors of carbonic anhydrase II with potential antiglaucoma activity	8
The potential of major kavalactones in modulating cytochrome P450 enzymes	8
In vitro antiproliferative activity of Parrotia persica exclusive gallotannin	8
Natural products in medicinal chemistry: targeting inflammatory pathways with plant-derived compounds	8
4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity	8
In silico drug discovery: a machine learning-driven systematic review	8
Discovery of novel acridine-chalcone hybrids with potent DNA binding and antiproliferative activity against MDA-MB-231 and MCF-7 cells	8
Design, synthesis, characterization and cytotoxic activity of new ortho-hydroxy and indole-chalcone derivatives against breast cancer cells (MCF-7)	8
Synthesis and evaluation of tetrahydrobenzo[cd]indole derivatives as glycogen phosphorylase inhibitors	8
Structural optimization and biological evaluation of quinoline/naphthalene-based glyoxalase-I inhibitors as anti-cancer candidates	8
Design, synthesis, in vitro evaluation, and molecular dynamics simulation studies of novel coumarin-acetohydrazide Schiff base derivatives as urease enzyme inhibitors	8
Synthesis of 6-dialkylaminopyrimidine carboxamide analogues and their anti-tubercular properties	8
Design, synthesis, stereochemical characterization, in vitro α-glucosidase, and α-amylase inhibition and in silico studies of novel pyrazole-hydrazide hydrazones	8
The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements	7
Glycosylated triptolide affords a potent in vivo therapeutic activity to hepatocellular carcinoma in mouse model	7
Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans	7
Harnessing the necessary nitrogen atom in chemical biology and drug discovery	7
New tetracyclic systems integrated thienopyridine scaffold as an anti-dementia lead: in silico study and biological screening	7
Anticancer and antimicrobial activities of new thiazolyl-urea derivatives: gene expression, DNA damage, DNA fragmentation and SAR studies	7
Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy	7
Exploring the latest breakthroughs in rhodesain inhibitors for African trypanosomiasis	7
Synthesis, characterization and biological evaluation of formononetin derivatives as anticancer agents	7
Synthesis, and docking studies of arylhydrazone compounds and evaluation of their platelet aggregation inhibitory effect and cytotoxicity	7
Research progress on antidiabetic activity of apigenin derivatives	7
Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48	7
Discovery and development of inhibitors of heat shock factor 1 by a fluorescence polarization assay	7
ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine	7
Acetylcholinesterase Inhibitors from Carbamate and Benzo-fused Heterocyclic Scaffolds: Promising Therapeutics for Alzheimer’s Disease	7
Does the negatively charged phosphate backbone contribute to stabilize the complex between cationic organic molecules and G-quadruplex structures? From guessing to calculating	7
Synthesis, pharmacological and molecular docking investigations of 1,3,4-oxadiazole-5-thionyl derivatives of extracted cis-clerodane diterpenoid from Cistus monspeliensis	7
CO as a potential therapeutic agent: an initial investigation of dosing and concentration dynamics in solution	7
A reliable and automated synthesis of 6-[18F]fluoro-L-DOPA and the clinical application on the imaging of congenital hyperinsulinism of infants	7
Anticancer potential of nicotinonitrile derivatives as PIM-1 kinase inhibitors through apoptosis: in vitro and in vivo studies	7
The emergence of sulfo-click amidation in kinetic target-guided synthesis	6
Synthesis of simplified didehydro-cortistatin A derivatives as anti-proliferative agents	6
Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model	6
Lenacapavir, a first-in-class, long-acting capsid inhibitor approved for both HIV-1 treatment and prevention	6
Synthesis and analgesic potential of 4-[4–chloro-3- (trifluoromethyl)-phenyl]-4-piperidinol analogues against pain model in mice	6
2-substituted 4-aminoquinazoline derivatives as potential dual inhibitors of EGFR and HER2: an in silico and in vitro study	6
An in vitro and in silico α-amylase/α-glucosidase/protein tyrosine phosphatase 1 beta & radical scavenging profiling of the 3,5,7-tricarbo substituted 1H-indazoles	6
Prenylated flavonoids icariin and icaritin for drug discovery: structural modifications and bioactivity studies	6
Investigation of the monoamine oxidase inhibition properties of benzoxathiolone derivatives	6
Synthesis and evaluation of new 2-oxo-1,2-dihydroquinoline-3-carboxamides as potent inhibitors against acetylcholinesterase enzyme	6
The anti-inflammatory effects of iridoid glycosides: a comprehensive review of mechanisms of action and structure-activity relationships	6
Novel vitamin K3 analogs containing 3-N-substituted aromatic and piperazine rings with selective in vitro anticancer activity against HeLa, U87 MG, and MCF-7 cells	6

Synthesis and anti-leishmanial activities of uniflorol analogues	6
Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their i	6
Hybrid-based design and biological evaluation of quinoline-benzoylhydrazine based derivatives as α-glucosidase inhibitors	6
Esters and amides of benzofuroxan-1-N–oxide derivatives as trypanocidal and leishmanicidal agents	6
A novel sight of the primary active compounds from Umbelliferae: focusing on mitochondria	6
Development of novel fluoro-substituted rivastigmine derivatives as selective AChE inhibitors for the treatment of AD	6
A second life for the crystallographic structure of Berenil-dodecanucleotide complex: a computational revisitation thirty years after its publication	6
Withania coagulans: a comprehensive exploration of its botanical, phytochemical, and pharmacological properties	6
Naturally occurring plant-derived sulfonated and sulfated saponins from 1983 to 2024	6
CO prodrugs: a new scaffold of adamantane-fused norbornen-7-ones with tunable water solubility	6
SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole	6
Benzocaine-N-acylindoline conjugates: synthesis and antiviral activity against Coxsackievirus B3	6
New indolo-β-lactam hybrids as potential anticancer and anti-inflammatory agents	6
Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen	6
Underpinning the role of natural products against cisplatin-induced nephrotoxicity in rodent models	6
Design, synthesis and anti-tumor activity evaluation of 4,6,7-substitute quinazoline derivatives	6
Promising Schiff bases in antiviral drug design and discovery	6
Novel Benzo[4,5]imidazo[1,2-a]pyrimidine derivatives as selective Cyclooxygenase-2 Inhibitors: Design, synthesis, docking studies, and biological evaluation	5
Design and synthesis of O-glycoside derivatives with promising antidiabetic and anticancer potential	5
The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations	5
Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications	5
Recent updates on thienopyrimidine derivatives as anticancer agents	5
Thiophene ring-opening reactions. Part VII: synthesis and antitumor, anti-inflammatory, and antioxidant properties of 1,3,4‒thiadiazoline‒6-sulfanylthiopyran-4(1H)-one hybrids	5
N-Phosphorylation of daunorubicin—synthetic approaches and antiproliferative properties of the products	5
An update on the discovery and development of reversible covalent inhibitors	5
Platanic acid derived amides are more cytotoxic than their corresponding oximes	5
Translational insights from species differences in the metabolism of triclosan	5
Correction to: Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria	5
Synthesis, biological evaluation, and molecular modeling studies of a new series of imidazothiazole or imidazooxazole derivatives as inhibitors of ectonucleoside triphosphate diphosphohydrolases (NTPD	5
Phytochemical constituents isolated from Silene popovii Schischk	5
The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds	5
Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-Alzheimer’s agents through pharmacophore-based virtual screening, molecular docking and experimental validation	5
Biocatalytic potential of microbial CYP450s in the degradation of selected environmental pollutants	5
Design, synthesis, and fungicidal activity of pyrimidinamine derivatives containing pyridin-2-yloxy moiety	5
Exploring nucleoside analogs: key targets in the viral life cycle - advancing strategies against SARS-CoV-2	5
Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants	5
Correction: Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model	5
Design and synthesis of aminothiazole-benzazole based amide: antiproliferative, antimigration activity and molecular docking studies	5
Acyl glucuronides–mediators of drug-induced toxicities?	5
Future challenges and opportunities with fluorine in drugs?	5
Insights into the α-amylase and α-glucosidase inhibition mechanism of 4-(4-hydroxyphenyl)-but-3-en-2-one from Scutellaria barbata D. Don: enzymatic kinetics, fluorescence spectroscopy and computationa	5
Evaluation of homodimer 99mTc-HYNIC-E(SSSLTVPWY)2 peptide on HER2-over expressed breast cancer cells	5
Design, synthesis, in vitro evaluation, and docking studies on ibuprofen derived 1,3,4-oxadiazole derivatives as dual α-glucosidase and urease inhibitors	5
Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics	5
Recent pharmacological insights about imidazole hybrids: a comprehensive review	5
Glutathione transferases in cats and dogs: diversity, structure, and function	5
Morpholinated curcuminoids against urinary bladder cancer cells: synthesis and anticancer evaluation	5
Evaluation of chemical constituents of Rooibos (Aspalathus linearis) and Honeybush (Cyclopia intermedia) as adenosine A1/A2A receptor ligands	4
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties	4
α-Glucosidase and cholinesterase inhibiting potential of a series of semisynthetic nitrogen triterpenic derivatives	4
A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy	4
Mannose: a potential saccharide candidate in disease management	4
Nafithromycin (MIQNAF®): ultramodern lactone ketolide designed to treat community acquired bacterial pneumonia (CABP)	4
Garcidepsidone B from Garcinia parvifolia: antimicrobial activities of the medicinal plants from East and North Kalimantan against dental caries and periodontal disease pathogen	4
Vital residues-orientated rational design of butenolide inhibitors targeting Of ChtI	4
Synthesis, cytotoxicity, Pan-HDAC inhibitory activity and docking study of new N-(2-aminophenyl)-2-methylquinoline-4-carboxamide and (E)-N-(2-aminophenyl)-2-styrylquinoline-4-carboxamide derivatives a	4
Phytochemistry and pharmacological activities of Tinospora genus: An updated review	4
Synthesis and antitumor activity of novel silibinin and 2,3-dehydrosilybin derivatives with carbamate groups	4
Anti-tumor metabolites from Synadenium grantii Hook F.	4
Design, synthesis and antiproliferative activity of ACY-1215 analogs as potent selective histone deacetylases 6 inhibitors	4
Current updates on EGFR and HER2 tyrosine kinase inhibitors for the breast cancer	4
Triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis, cytotoxicity and antimicrobial activity	4
An evaluation of spirooxindoles as blocking agents of SARS-CoV-2 spike/ACE2 interaction: synthesis, biological evaluation and computational analysis	4
Synthesis, urease inhibitory and anticancer evaluation of glucosamine-sulfonylurea conjugates	4
Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications	4
Design, synthesis and antitumor activity study of tubulin/HDAC6 dual targeting inhibitor	4
From the ethnomedicinal plants in northern Indochina to the development of novel anti-cancer therapeutic agents	4
Isatin derivatives as broad-spectrum antiviral agents: the current landscape	4
Integrating omics data for personalized medicine in treating psoriasis	4
Synthesis and biological evaluation of sulfamate derivatives as inhibitors of carbonic anhydrases II and IX	4
Design, synthesis, and biological evaluation of catalpalactone and its analogs	4
Lead change of a HIF-2α antagonist guided by multiparameter optimization and utilization of an Olp→π*Ar interaction	4
Position switch of phenylthiazoles: novel compounds with promising anti-MRSA USA300	4
Design, synthesis and antitumor activity evaluation of 5-cyano-2,4,6-substituted pyrimidine derivatives containing acrylamide group	4
Facile access to novel furoyl-based amide retroisoster inhibitors of LuxR-regulated quorum sensing: conformation analysis and docking studies	4
Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment	4
Design, synthesis and antitumor activity evaluation of 4,6,7-trisubstituted quinazoline derivatives containing benzothiazole moiety	4
Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors	4
Identification and evaluation of potent AAK1 inhibitors through structure-based pharmacophores, virtual screening and bioassay screening	4
Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments	4
Design, synthesis, and biological evaluation of novel 2-acetylphenol-rivastigmine hybrids as potential multifunctional agents for the treatment of Alzheimer’s disease	4
Neuroprotective role of nobiletin against amyloid-β (Aβ) aggregation in Parkinson and Alzheimer disease as neurodegenerative diseases of brain	4
Cyclohepta[b]pyran: an important scaffold in biologically active natural products	4
Recent advances in structural types and medicinal chemistry of PARP-1 inhibitors	4
Design, synthesis, molecular docking study and molecular dynamics simulation of new coumarin-pyrimidine hybrid compounds having anticancer and antidiabetic activity	4
Targeting MDM2 for the development of a new cancer therapy: progress and challenges	4
Design & synthesis of hybrid pharmacophore of β-lactam, 1,8-naphthyridine, and secondary amines; Discover their in vitro antimicrobial, anticancer properties & DFT and ADMET prediction studies	4
Discovery of oxazolidinone-based heterocycles as subtype selective sigma-2 ligands	4
A review on efficacy of phytochemicals in the treatment of trypanosomiasis	4
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain	4
Design, synthesis and assay of 2-(4-phenylpiperazin-1-yl)pyrimidine-5- carboxamide derivatives as acetylcholinesterase inhibitors	4
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective	4
Gallic acid derived diarylpropanones exhibit synergistic antibacterial activities	4
Special issue in honor of Prof. Laurence H. Hurley	4
Potential effect of novel thiadiazole derivatives against radiation induced inflammation with low cardiovascular risk in rats	4