Medicinal Chemistry Research

Article	Citations
Synthesis, characterization and in vitro antitumor activity of asiatic acid derivatives	120
Potent α-glucosidase inhibitory activity of inoscavin A from fruiting bodies of Fulvifomes fastuosus: Mechanism of action, molecular docking and ADMET	104
Targeting cAMP signaling and phosphodiesterase 4 for liver disease treatment	88
Synthesis and antitumor activity evaluation in vitro of 4-aminoquinazoline derivatives containing 1,3,4-thiadiazole	78
Computer-aided design, synthesis and evaluation of new SARS-CoV-2 Mpro inhibitors based on 1,5,6,7-tetrahydro-4H-indazol-4-one scaffold	68
Structural simplification and ester bond flipping lead to bis-benzodioxole derivatives as potential hypolipidemic and hepatoprotective agent	62
Design, synthesis, and antitumor activity evaluation of carbazole derivatives with potent HDAC inhibitory activity	58
Carbamoyl flavonoids as dual inhibitors of acetylcholinesterase and monoacylglycerol lipase: synthesis, in vitro evaluation, and computational studies	54
Antibacterial, antifungal activities and toxicity of new synthetic fatty acid salicylate esters	51
Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study	51
Synthesis of novel benzothieno-[3,2’-f][1,3] oxazepines and their isomeric 2-oxo-2H-spiro[benzothiophene-3,3’-pyrrolines] via 1,4-dipolar cycloaddition reaction and their evaluation as cytotoxic antic	47
Asciminib: first FDA approved allosteric inhibitor of BCR-ABL1 for the treatment of chronic myeloid leukemia	44
Anticancer activity of amide and ester derivatives of the ent-labdane 2α-hydroxyeperuic acid obtained via sonochemical synthesis	39
Synthesis of the dibenzylbutane lignan LCA derivatives and evaluation of their anti-inflammatory activities	39
Monoamine oxidase inhibition by thiazole derivatives substituted with the benzenesulfonamide moiety	38
Synthesis of berberine derivatives and their antiviral activity toward respiratory syncytial virus	38
Novel imino-thiazoloquinoxaline derivatives against renal cell carcinoma: less radiation-damaging approach	35
Glutathione and glutathione disulfide – their biomedical and pharmaceutical applications	34
Design, synthesis and anti-breast cancer properties of butyric ester tethered dihydroartemisinin-isatin hybrids	34
Screening of small molecule compounds targeting hnRNPA2 protein	33
Synthesis of tetrahydro-β-carboline analogs with N11 modifications and study of their antimalarial activities	33
Bio-guided isolation of anti-Alzheimer’s compounds from Phyllanthus niruri and role of niruriflavone in the reversal of aluminum chloride-induced neurobehavioral and biochemical changes in an animal m	33
Contrasting effect of different crowding agents on pseudoknot RNA stability	30
Design and synthesis of diphenyl-1H-imidazole analogs targeting Mpro/3CLpro enzyme of SARS-CoV-2	30
Evaluation of benzoylacetonitriles as novel anti-neuroinflammatory agents	29

A versatile strategy for the synthesis of various lumazine peptides	29
Plant-derived pyroptosis inducers as a therapeutic strategy in drug-resistant cancers	29
Utilizing mechanistic organic chemistry training to study drug metabolism in preclinical drug discovery/development	24
4’-Thionucleosides as adenosine A3 receptor ligands: a medicinal chemistry perspective	23
Synthesis, crystal structure, and anticancer activity of organotin(IV) complexes based on chlorine substituted aryl ligands	22
Recent advances in triazole-benzenesulfonamide hybrids and their biological activities	21
Pyrrolobenzodiazepines: natural sources, therapeutic uses, and future in neurological treatments	20
Design, Synthesis, and biological evaluation of pyrazolo-benzothiazole derivatives as a potential therapeutic agent for the treatment of Alzheimer’s disease	20
Synthesis, inhibition effects, molecular docking and theoretical studies as Paraoxonase 1 (PON1) inhibitors of novel 1,4-dihydropyridine substituted sulfonamide derivatives	20
Discovery of 3-(N-phenylsulfamoyl)-l-phenylalanine derivatives as novel and orally available LAT1-selective inhibitors	20
Enantioselectivity of pinene against Leishmania amazonensis	18
Synthesis and antihepatoma activity of dimeric 1-O-acetylbritannilactone derivatives	18
Synthesis of nitrogen-containing oleanolic acid derivatives as carbonic anhydrase and acetylcholinesterase inhibitors	18
Dual-PROTACs based on natural product derivative potassium dehydrographolide succinate: design, synthesis, and antitumor activity of a novel EGFR degrader	18
Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review	18
Synthesis and biological evaluation of esculetin derivatives as potential anti-HBV agents	17
Synthesis, bacteria activity and molecular simulation of D-galactose-conjugated thiosemicarbazones of 3-aryl-4-formylsydnones	17
α-Glucosidase inhibitory activities of aromatic compounds from the rhizomes of Alpinia galanga	17
Novel conjugated 5-alkenyl rhodanine tethered 1,4-benzodioxane derivatives as dual-chitinases inhibitors to hinder the growth of Asian corn borer	17
Synthetic studies toward a simplified eleuthoside core	17
Design, synthesis and evaluation of salicylic acid-donepezil hybrids as functional agents for the treatment of Alzheimer’s disease	17
Pks 13 inhibitors—a promising target for future antitubercular agents	16
Synthesis and in vitro anti-trypanosomal evaluation of quinolone hydrazide analogues	16
Acylhydrobenzoquinones influence the susceptibility of Staphylococcus aureus towards abietanes and the speciation within Plectranthus sensus lato	16
Development of new donepezil analogs: synthesis, biological screening and in silico study rational	16
Design, synthesis and insecticidal activities of novel meta-diamide compounds containing ethyl group	16
Role of natural secondary metabolites as HIF-1 inhibitors in cancer therapy	16
Design, synthesis, and activity study of heterocyclic derivatives as JAK inhibitors	15
1,2,3-triazenes and 1,2,3-triazoles as antileishmanial, antitrypanosomal, and antiplasmodial agents	15
Exploring thiazole-linked thioureas using alkaline phosphatase assay, biochemical evaluation, computational analysis and structure–activity relationship (SAR) studies	15
Novel indanone-chalcone esters with potential anti-Alzheimer effects designed using hybridization and bioisosteric replacement approaches	14
A Click Synthesis, Molecular Docking and Biological Evaluation of 1,2,3-triazoles-benzoxazepine hybrid as potential anticancer agents	13
Synthesis and biological evaluation of coumarin derivatives as anti-lung adenocarcinoma agents via induction of apoptosis and autophagy: in vitro and in vivo studies	13
In vitro cytotoxicity evaluation of triphenylphosphonium (TPP) conjugates of some acetylenated nucleic bases and their analogues	13
Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation	13
Antitumor studies on celastrol and its derivatives as RORα agonists and RORγ inhibitors based on Alphafold reverse docking strategy	13
Molecular hybridization method for obtaining paeonol-based fibrate derivatives with potent lipid-lowering and hepatoprotective activity	13
Synthesis, antiviral evaluation, molecular docking study and cytotoxicity of 5′-phosphorylated 1,2,3-triazolyl nucleoside analogues with thymine and 6-methyl uracil moieties	13
Synthesis, characterization, and anticancer activity of syringaldehyde-derived chalcones against female cancers	12
Novel 2-aminopyrimidine Schiff bases as possible GABA-AT inhibitors: molecular docking, MAOS, and pharmacological screening	12
Synthesis and biological evaluation of triazole alcohols containing an indole-3-methyl(phenyl)amino side chain against fluconazole-resistant Candida albicans	12
Dual-target inhibitors based on brpf1: a review from medicinal chemistry perspectives	12
Design, synthesis and antitumor activity evaluation of 2,4,6-trisubstituted quinazoline derivatives containing piperidine moiety	12
New structural scaffold discovery via fragment-based drug design: Hydroxymethyl indazole derivatives as XOR/URAT1 dual inhibitors	12
Synthesis and biological assessment of triazolo-quinazoline carbothioamide derivatives for p38 MAP kinase inhibition: in-silico and in-vitro approaches	11
A fast high-throughput logP estimation method for peptide molecules based on liquid chromatography-mass spectrometry method	11
A potent therapeutic scaffold fusing quinazolinone/melatonin for future colorectal cancer interventions: design, one-pot synthesis, biological and ADME-tox modeling studies	11
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells	11
Development of new coumarin-piperazine-N-phenylacetamid derivatives as potent tyrosinase inhibitors: In vitro and in silico evaluations	11
Site-Specific incorporation of lysine acetyl-methylation into proteins	11

The metabolic fate of izencitinib, a gut-selective pan-JAK inhibitor, in humans. Identification of unusual fecal metabolites and implications for MIST evaluation	11
Designations of new biological drugs	11
Dynamic tail amine interactions drive isoform selectivity for potent human neuronal nitric oxide synthase inhibitors	11
Insights on synthetic strategies and structure-activity relationship of donepezil and its derivatives	11
Discovery of quinazoline-based derivatives as novel autophagy inhibitors in pancreatic cancer	11
Antivirulence therapy: type IV pilus as a druggable target for bacterial infections	10
Antiproliferative effect, cell cycle arrest and apoptosis generation of novel 6-substituted N5-formyltetrahydropyrido[3,2-d]pyrimidine derivatives	10
A comprehensive review of 11C-, 18F-, and 123/124/125I-labeled radiotracers targeting cyclooxygenase-2 over the past two decades	10
Rehmannia glutinosa polysaccharides: a review on structure-activity relationship and biological activity	10
Glycyrrhizin and its derivatives: an emerging secondary metabolite arsenal of Glycyrrhiza glabra	10
Discovery of novel HCV inhibitors: design, synthesis and biological activity of phthalamide derivatives	10
Design, synthesis and evaluation of aurone and indanone derivatives as novel antitumor agents	10
Synthesis and pharmacological evaluation of new disulfides linked to 1,2,4-triazole bearing urea moiety	10
Discovery of α-methylene-γ-lactone-δ-epoxy derivatives with anti-cancer activity: synthesis, SAR study, and biological activity	10
Kaempferia diterpenoids and flavonoids: an overview on phytochemistry, biosynthesis, synthesis, pharmacology, and pharmacokinetics	9
Discovery of potent maternal embryonic leucine zipper kinase (MELK) inhibitors of novel chemotypes using structure-based pharmacophores	9
Pharmacological assessment of disulfide–triazine hybrids: synthesis, enzyme inhibition, and molecular docking study	9
Discovery of mobocertinib, a new irreversible tyrosine kinase inhibitor indicated for the treatment of non-small-cell lung cancer harboring EGFR exon 20 insertion mutations	9
Polyalthia longifolia: phytochemistry, ethnomedicinal importance, nutritive value, and pharmacological activities review	9
Synthesis and in vitro biological activity of chalcone derivatives as potential antiparasitic agents	9
Synthesis, in vitro activity, and molecular docking of caffeic acid and resveratrol derivatives against Alzheimer’s disease-related enzymes	9
CYP3A4 drug metabolism considerations in pediatric pharmacotherapy	9
Design, synthesis and molecular docking studies of novel benzimidazole-1,3,4-oxadiazole hybrids for their carbonic anhydrase inhibitory and antioxidant effects	9
Structural modification of (‒)-xanthorrhizol isolated from Curcuma aromatica rhizomes to analogs with potent nitric oxide inhibitory activities	9
Assessment of the α-glucosidase and α-amylase inhibitory potential of Paliurus spina-christi Mill. and its terpenic compounds	9
Lipase inhibitory activity of constituents of Physalis glutinosa and Physalis latiphysa	8
Unrevealing the Role of Flavonoids in Mitigation of Non-Alcoholic Fatty Liver Disease	8
The potential of chalcone derivatives as human carbonic anhydrase inhibitors in the therapy of glaucoma	8
Design, synthesis, stereochemical characterization, in vitro α-glucosidase, and α-amylase inhibition and in silico studies of novel pyrazole-hydrazide hydrazones	8
Discovery of novel pterostilbene/biphenyl tethered 5-FU based conjugates targeting colorectal cancer: synthesis, cytotoxic and ADMET modeling studies	8
Synthesis and inhibitory activity against enzymes responsible for Type 2 diabetes mellitus of lactose-conjugated thiosemicarbazones from substituted acetophenones	8
The potential of major kavalactones in modulating cytochrome P450 enzymes	8
Advances in quercetin-based therapeutics for breast cancer: natural, synthetic, and nanotechnology-driven approaches	8
Integrated 3D-QSAR and cellular profiling of sulfated and hydrophobic aminoglycoside glycans to modulate heparanase activity	8
Sphingosine 1-phosphate receptor modulators for the treatment of inflammatory bowel disease and other immune-mediated diseases	8
Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells	8
From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of A1 and A3 adenosine receptors	8
Sulfonamide-substituted oxindoles as inhibitors of carbonic anhydrase II with potential antiglaucoma activity	8
In silico drug discovery: a machine learning-driven systematic review	8
Design, synthesis, and neuroprotective activity of salidroside-based dual inhibitors of selective monoamine oxidase B and amyloid-β aggregation	8
Synthesis, theoretical investigations and biological evaluation of ibuprofen drug hybrids	8
Stable isotope applications in drug development and the elucidation of mechanisms of drug metabolism	8
Synthesis, and docking studies of arylhydrazone compounds and evaluation of their platelet aggregation inhibitory effect and cytotoxicity	7
Synthesis, characterization and biological evaluation of formononetin derivatives as anticancer agents	7
Synthesis and evaluation of tetrahydrobenzo[cd]indole derivatives as glycogen phosphorylase inhibitors	7
Hit-to-lead optimization of amino-carboxamide benzothiazoles as LSD1 inhibitors	7
Ferrocene-based compounds: promising anticancer and antimalarial agents in modern therapeutics	7
Tropanes in natural products, syntheses, and drugs: some insights from the new millennium	7
ATP-hydrolyzing, DNA-damaging and cytotoxic activities of peptide-targeted cobalt(III) complex with diethylentriamine	7
Discovery of phenylacetamide derivatives as novel STAT3 antagonists	7
A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry	7
Synthesis, structure-activity relationship and evaluation of antifungal activity of tryptanthrin derivatives against drug-resistant Candida albicans	7
Design, synthesis, in vitro evaluation, and molecular dynamics simulation studies of novel coumarin-acetohydrazide Schiff base derivatives as urease enzyme inhibitors	7
The emerging role of proteolysis targeting chimeras (PROTACs) in the treatment of Alzheimer’s disease	7
Does the negatively charged phosphate backbone contribute to stabilize the complex between cationic organic molecules and G-quadruplex structures? From guessing to calculating	7
Translating G-quadruplex ligands from bench to bedside: a Stephen Neidle’s legacy	7
Glycosylated triptolide affords a potent in vivo therapeutic activity to hepatocellular carcinoma in mouse model	7
Structural optimization and biological evaluation of quinoline/naphthalene-based glyoxalase-I inhibitors as anti-cancer candidates	7
Synthesis of 6-dialkylaminopyrimidine carboxamide analogues and their anti-tubercular properties	7
Natural products in medicinal chemistry: targeting inflammatory pathways with plant-derived compounds	7
Acetylcholinesterase Inhibitors from Carbamate and Benzo-fused Heterocyclic Scaffolds: Promising Therapeutics for Alzheimer’s Disease	7
Engelheptanoxides behave as liver X receptor α agonists	7
4,5-diazafenylfluorene-rhodanine conjugates promote anoikis in A375 cells via inhibiting PPAR-γ expression	7
In vitro antiproliferative activity of Parrotia persica exclusive gallotannin	7
Molecular sonification: a multi-modal approach for enhanced ai in drug discovery	7
Exploring the latest breakthroughs in rhodesain inhibitors for African trypanosomiasis	7
Novel P2X4 Receptor Antagonist MRS4719 Improves Ischemia/reperfusion Injury in Mice	7
4-Phenylcoumarins from Mesua ferrea with selective CYP1B1 inhibitory activity	7
Novel vitamin K3 analogs containing 3-N-substituted aromatic and piperazine rings with selective in vitro anticancer activity against HeLa, U87 MG, and MCF-7 cells	6
Prenylated flavonoids icariin and icaritin for drug discovery: structural modifications and bioactivity studies	6
Anticancer potential of nicotinonitrile derivatives as PIM-1 kinase inhibitors through apoptosis: in vitro and in vivo studies	6
The use of single-molecule FRET for the characterization of Holliday junctions containing human telomeric DNA: a methodological approach for nanoscale distance, mobility, and stability measurements	6
Identification of α-mangostin as a potent inhibitor of β-lactamase OXA-48	6
Benzocaine-N-acylindoline conjugates: synthesis and antiviral activity against Coxsackievirus B3	6
A second life for the crystallographic structure of Berenil-dodecanucleotide complex: a computational revisitation thirty years after its publication	6
New indolo-β-lactam hybrids as potential anticancer and anti-inflammatory agents	6
Naturally occurring plant-derived sulfonated and sulfated saponins from 1983 to 2024	6
CO prodrugs: a new scaffold of adamantane-fused norbornen-7-ones with tunable water solubility	6
Inactivation of ornithine aminotransferase by (1R,4S)-4-Amino-3-(trifluoromethyl)cyclopent-2-ene-1-carboxylic acid via a stable quinonoid intermediate	6
Lenacapavir, a first-in-class, long-acting capsid inhibitor approved for both HIV-1 treatment and prevention	6

New tetracyclic systems integrated thienopyridine scaffold as an anti-dementia lead: in silico study and biological screening	6
Discovery and development of inhibitors of heat shock factor 1 by a fluorescence polarization assay	6
CO as a potential therapeutic agent: an initial investigation of dosing and concentration dynamics in solution	6
Synthesis, pharmacological and molecular docking investigations of 1,3,4-oxadiazole-5-thionyl derivatives of extracted cis-clerodane diterpenoid from Cistus monspeliensis	6
SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole	6
Piperazine derivatives as anticancer agents: a medicinal chemistry review of structure, mechanism, and clinical translation	6
Siderophore–Porphyrin conjugates for bacteria-selective antimicrobial photodynamic therapy	6
Underpinning the role of natural products against cisplatin-induced nephrotoxicity in rodent models	6
Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule and their i	6
Hybrid-based design and biological evaluation of quinoline-benzoylhydrazine based derivatives as α-glucosidase inhibitors	6
Synthesis of simplified didehydro-cortistatin A derivatives as anti-proliferative agents	6
Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model	6
Design, synthesis and anti-tumor activity evaluation of 4,6,7-substitute quinazoline derivatives	6
Harnessing the necessary nitrogen atom in chemical biology and drug discovery	6
Research progress on antidiabetic activity of apigenin derivatives	6
Esters and amides of benzofuroxan-1-N–oxide derivatives as trypanocidal and leishmanicidal agents	6
Development of novel fluoro-substituted rivastigmine derivatives as selective AChE inhibitors for the treatment of AD	6
Design and synthesis of novel cycloalkanecarboxamide parabanic acid hybrids as anticonvulsants	6
Synthesis and anti-leishmanial activities of uniflorol analogues	6
An in vitro and in silico α-amylase/α-glucosidase/protein tyrosine phosphatase 1 beta & radical scavenging profiling of the 3,5,7-tricarbo substituted 1H-indazoles	6
Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen	6
Promising Schiff bases in antiviral drug design and discovery	6
Acyl glucuronides–mediators of drug-induced toxicities?	5
Preliminary structure−activity relationships analysis on N-(3,5-dichlorophenyl)-4,5-dihydronaphtho[1,2-d]thiazol-2-amine, a disruptor of mycobacterial energetics	5
Design and synthesis of aminothiazole-benzazole based amide: antiproliferative, antimigration activity and molecular docking studies	5
Evaluation of homodimer 99mTc-HYNIC-E(SSSLTVPWY)2 peptide on HER2-over expressed breast cancer cells	5
Design and synthesis of O-glycoside derivatives with promising antidiabetic and anticancer potential	5
Correction to: Structure-activity relationships and pharmacokinetic evaluation of L-cystine diamides as L-cystine crystallization inhibitors for cystinuria	5
Investigation of the monoamine oxidase inhibition properties of benzoxathiolone derivatives	5
Synthesis and evaluation of new 2-oxo-1,2-dihydroquinoline-3-carboxamides as potent inhibitors against acetylcholinesterase enzyme	5
The anti-inflammatory effects of iridoid glycosides: a comprehensive review of mechanisms of action and structure-activity relationships	5
Translational insights from species differences in the metabolism of triclosan	5
Morpholinated curcuminoids against urinary bladder cancer cells: synthesis and anticancer evaluation	5
Recent pharmacological insights about imidazole hybrids: a comprehensive review	5
Discovery of novel fatty acid amide hydrolase (FAAH) inhibitors as anti-Alzheimer’s agents through pharmacophore-based virtual screening, molecular docking and experimental validation	5
Flavonoids as colchicine binding site inhibitors: emerging scaffolds in anticancer drug design	5
Thiophene ring-opening reactions. Part VII: synthesis and antitumor, anti-inflammatory, and antioxidant properties of 1,3,4‒thiadiazoline‒6-sulfanylthiopyran-4(1H)-one hybrids	5
An update on the discovery and development of reversible covalent inhibitors	5
Exploring nucleoside analogs: key targets in the viral life cycle - advancing strategies against SARS-CoV-2	5
The emergence of sulfo-click amidation in kinetic target-guided synthesis	5
Withania coagulans: a comprehensive exploration of its botanical, phytochemical, and pharmacological properties	5
Correction: Substituted furan-carboxamide and Schiff base derivatives as potential hypolipidemic compounds: evaluation in Triton WR-1339 hyperlipidemic rat model	5
The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds	5
Phytochemical constituents isolated from Silene popovii Schischk	5
Insights into the α-amylase and α-glucosidase inhibition mechanism of 4-(4-hydroxyphenyl)-but-3-en-2-one from Scutellaria barbata D. Don: enzymatic kinetics, fluorescence spectroscopy and computationa	5
Synthesis, biological evaluation, and molecular modeling studies of a new series of imidazothiazole or imidazooxazole derivatives as inhibitors of ectonucleoside triphosphate diphosphohydrolases (NTPD	5
Glutathione transferases in cats and dogs: diversity, structure, and function	5
4-methylbenzyl 5-arylthiophene-2-carboxylates as Multitarget Directed Ligands Scaffolds (MTDLs): Synthesis, in-silico docking studies, and evaluation of dual selective enzymatic inhibition (AChE &	5
Novel Benzo[4,5]imidazo[1,2-a]pyrimidine derivatives as selective Cyclooxygenase-2 Inhibitors: Design, synthesis, docking studies, and biological evaluation	5
Design, synthesis, and fungicidal activity of pyrimidinamine derivatives containing pyridin-2-yloxy moiety	5
α-Glucosidase and cholinesterase inhibiting potential of a series of semisynthetic nitrogen triterpenic derivatives	4
From the ethnomedicinal plants in northern Indochina to the development of novel anti-cancer therapeutic agents	4
Cyclohepta[b]pyran: an important scaffold in biologically active natural products	4
Investigating novel tubulin polymerization inhibitors: design, synthesis, LC/MS cellular permeability, in silico studies, and in vitro assessment	4
Facile access to novel furoyl-based amide retroisoster inhibitors of LuxR-regulated quorum sensing: conformation analysis and docking studies	4
Current updates on EGFR and HER2 tyrosine kinase inhibitors for the breast cancer	4
A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy	4
Design, synthesis and antitumor activity evaluation of 4,6,7-trisubstituted quinazoline derivatives containing benzothiazole moiety	4
Recent updates on thienopyrimidine derivatives as anticancer agents	4
Synthesis, cytotoxicity, Pan-HDAC inhibitory activity and docking study of new N-(2-aminophenyl)-2-methylquinoline-4-carboxamide and (E)-N-(2-aminophenyl)-2-styrylquinoline-4-carboxamide derivatives a	4
Iron porphyrin-mediated production of carbon monoxide from phenylpyruvic acid: from potential therapeutic and diagnostic use to physiological implications	4
Design, synthesis and antifungal study of novel 2-aryl-3,4-dihydroisoquinolin-2-ium salts containing benzoate moieties	4
Design & synthesis of hybrid pharmacophore of β-lactam, 1,8-naphthyridine, and secondary amines; Discover their in vitro antimicrobial, anticancer properties & DFT and ADMET prediction studies	4
Current CMC challenges in oligonucleotide API development: from IND to NDA	4
Design, synthesis and assay of 2-(4-phenylpiperazin-1-yl)pyrimidine-5- carboxamide derivatives as acetylcholinesterase inhibitors	4
Unveiling the potential of prodrug and drug-conjugate strategies in treatment of diabetes mellitus and its complications	4
Potential effect of novel thiadiazole derivatives against radiation induced inflammation with low cardiovascular risk in rats	4
SAR exploration for 4-aminotetrahydroquinazolines with adamantyl moiety against orthoflaviviruses	4
Gallic acid derived diarylpropanones exhibit synergistic antibacterial activities	4
Nafithromycin (MIQNAF®): ultramodern lactone ketolide designed to treat community acquired bacterial pneumonia (CABP)	4
Recent advances in piperidones as privileged scaffolds for drug discovery and development	4
Design, synthesis and antitumor activity study of tubulin/HDAC6 dual targeting inhibitor	4
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain	4
Exploring the potential of isatin hybrids as anticancer agents: recent advances and future prospective	4
From lipophilicity windows to decision-grade antibacterial design: the next translational step for coumarin amphiphiles	4
Position switch of phenylthiazoles: novel compounds with promising anti-MRSA USA300	4
Future challenges and opportunities with fluorine in drugs?	4
Vital residues-orientated rational design of butenolide inhibitors targeting Of ChtI	4
Synthesis, urease inhibitory and anticancer evaluation of glucosamine-sulfonylurea conjugates	4
Design, synthesis and antiproliferative activity of ACY-1215 analogs as potent selective histone deacetylases 6 inhibitors	4
Garcidepsidone B from Garcinia parvifolia: antimicrobial activities of the medicinal plants from East and North Kalimantan against dental caries and periodontal disease pathogen	4
Design and synthesis of novel factor XIa Inhibitors with bicyclic isoquinoline and naphthalene fragments	4
Identification and evaluation of potent AAK1 inhibitors through structure-based pharmacophores, virtual screening and bioassay screening	4
Phenoxyalkyl cyclic and acyclic amine derivatives: what do they teach us about scaffold-based drug design?	4
Triphenylphosphonium (TPP) conjugates of 1,2,3-triazolyl nucleoside analogues. Synthesis, cytotoxicity and antimicrobial activity	4
Targeting MDM2 for the development of a new cancer therapy: progress and challenges	4
Correction: Bioassay-guided fractionations of Cannabis sativa extract and HPLC-assisted purifications of anti-proliferative active fractions lead to the isolation of 16 known and one new phytomolecule	4
Correction: Anticancer therapeutic potential of silibinin: current trends, scope and relevance	4
Structure-based optimization of aminothiadiazole inhibitors of AKT	4
Pharmacodynamic material basis investigations of the crude and processed Radix et Rhizoma Rhei by the immobilized β2-adrenoceptor chromatography	4
The history, mechanism, and perspectives of nirmatrelvir (PF-07321332): an orally bioavailable main protease inhibitor used in combination with ritonavir to reduce COVID-19-related hospitalizations	4
Biocatalytic potential of microbial CYP450s in the degradation of selected environmental pollutants	4
Design, synthesis and profiling of proteolysis-targeting chimeras (PROTACs) as CDK4/6 degraders	4
Development and evaluation of mitochondria-targeted caseinolytic protease (ClpP) agonist chemical probes in in vitro breast cancer models	4
Integrating omics data for personalized medicine in treating psoriasis	4