Journal of Pharmacological and Toxicological Methods

Papers
(The median citation count of Journal of Pharmacological and Toxicological Methods is 0. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)
ArticleCitations
First-order compartment model solutions – Exponential sums and beyond26
Editorial Board24
Validation of a simple spectrophotometric method for the rapid determination of salicylates in plasma23
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes16
A comparison of activity data generated from cardiovascular telemetry studies - With quantitative open field locomotor studies in Wistar Han rats16
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods16
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis14
Editorial Board14
A novel device for serial venous blood sampling in a canine model13
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species13
Flavonoids from Chromolaena leivensis and Caesalpinia spinosa as potential protectors against doxorubicin-induced cardiomyopathy12
Human iPS cell-derived cardiomyocytes aligning on flexible gelatin fiber network show contraction and pharmacological responses relevant to human heart11
An integrative computational platform for the multiparametric analysis of cardiomyocyte signals10
Three in silico human iPSC cardiomyocyte models to recapitulate in vitro drug trials10
Improved screening of the cardiovascular safety of COVID-19 anti-viral compounds10
Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study10
Effect of hydroxychloroquine on proarrhythmia risk assessment using human iPSC-derived cardiomyocytes9
MEA assessment to anti-epilepsy drugs in human iPSC-derived neural network8
Chronic bladder catheterization for precise urine collection in awake mice8
Modeling chemotherapy-induced peripheral neuropathy using a nerve-on-a-chip microphysiological system8
Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk8
The underlying molecular mechanisms of drug-induced seizures8
Visualizing QT prolongation in the anesthetized guinea pig7
Biological variations in hemodynamics and electrocardiogram rhythms among telemetered cynomolgus monkeys7
Identification of pharmacological targets involved in drug-induced thermoregulation impairment7
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak7
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress6
Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity6
Characteristics of histamine H4 receptor agonist-induced allergic conjunctivitis model in Guinea pigs6
A fast optical kinetic plate reader for assessing action potentials in human-induced pluripotent stem cell cardiomyocytes6
Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations6
Acute cell stress screen with supervised machine learning predicts cytotoxicity of excipients6
Contractility assessment using aligned human iPSC-derived cardiomyocytes6
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine6
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models6
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization5
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms5
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties5
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis5
Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium5
Comparative analysis of high-throughput RNA extraction kits in Naïve Non-Human Primate (NHP) tissues for downstream applications utilizing Xeno Internal Positive Control (IPC)5
A highly efficient liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay for etomidate and etomidate acid in urine, liver and kidney5
Drug-target interaction prediction using reliable negative samples and effective feature selection methods4
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry4
Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes4
An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum4
“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead4
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization4
The efficient method to get better raw brain signal on rat anesthetics experiment4
Assessment of sarcomere shortening and calcium transient in primary human and dog ventricular myocytes4
Non-invasive method of obtaining milk from mice using carbetocin, a synthetic analogue of oxytocin4
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies4
A stable cell line inducibly expressing hERG1a/1b heteromeric channels4
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry4
Understanding lymphatic drug delivery through chylomicron blockade: A retrospective and prospective analysis4
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells4
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice3
Comparison of SYBR green I and lactate dehydrogenase antimalarial in vitro assay in Plasmodium falciparum field isolates3
Evaluation of three different 99mTc-based mock-venom agents for lymphoscintigraphy studies in preclinical models of peripheral snakebite envenomation3
Contractility assessment of human iPSC-derived cardiomyocytes by using a motion vector system and measuring cell impedance3
Mechanical stimulation in a 2D high-throughput contractility system induces functional changes in human induced pluripotent stem cell-derived cardiomyocytes3
Effects of intracellular fluoride and temperature on hERG blocker potency in vitro3
HS-GC-FID method for quantification of HFA-152a in cell culture media, and plasma from a range of species and regulatory compliant validations3
In vitro cardiac safety evaluation for repurposed COVID-19 drugs by using human iPS cell-derived cardiomyocyte with gelatin fiber scaffold3
Human engineered cardiac tissues grown in a plate-based platform for analysis of acute and chronic contractility response3
Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration3
Screening of anticonvulsant activity of Xylopia aethiopica dry fruit using zebrafish3
Editorial Board3
Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity3
Editorial Board3
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B63
Late sustained sodium current in the adult human heart3
Standardization and validation of novel ex-vivo method for mitochondrial bioenergetics using mitochondrial modulators3
Blood microsampling in cynomolgus monkey and evaluation of plasma PK parameters in comparison to conventional sampling3
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals3
A bioanalytical assay for estimation of thymoquinone in rats cerebrospinal fluid and brain tissues of nasally administrated thymoquinone loaded lipo-polymeric nanoshells and its pharmacokinetic profil2
Automated cardiac tissue assay system with perfusion for monitoring contractility2
Drug testing using a novel in silico human cardiac Purkinje cell model and comparison with experimental data2
An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds2
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments2
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys2
A rapid spectrophotometric method to identify inhibitors of human erythropoiesis2
Overcoming obstacles in three-dimensional cell culture model establishment: Approaches for growing A549 non-small cell lung cancer spheroids using a clinostat system2
Assessment of intracellular accumulation of cadmium and thallium2
Editorial Board2
Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies2
Assessment of cardiac safety liabilities via 3D engineered heart tissue contractility using a novel high-throughput instrumentation platform2
Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model2
Revisiting the high-fat diet/low streptozotocin prediabetic rat model: A bioanalytical adjustment2
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)2
L-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies2
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins2
Innovative approaches to cardiovascular safety pharmacology assessment2
Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility2
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability2
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells2
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes2
Corrigendum to “The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies” [Jour2
Ultraviolet spectrophotometry as method to determine the concentration of β-myrcene released from chitosan in aqueous medium2
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry2
Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development1
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS1
Comparison between collagen and fibrin matrices in 3D cardiac tissue engineering1
Development of a medium throughput whole-cell microtiter plate Thr286 autophosphorylation assay for CaMKIIα using ELISA1
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models1
Lung physiology and controlled exposure study design1
A cross-species comparison study of undesired drug-induced hypothermia using telemetry1
Neuroelectrophysiology assays performed on dorsal root ganglion from non-human primate and rodent origins1
High throughput measurement of hERG drug block kinetics using the CiPA dynamic protocol1
QA interval heart rate correction: Species comparison of an indirect ventricular contractility biomarker1
Editorial Board1
Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia1
Model versus scientist: Cardiac toxicity predictions—safety pharmacologists correlate with the CiPA model1
Chicken embryo as animal model to study drug distribution to the developing brain1
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute1
Method of transverse aortic constriction in mice with reduced variability of the aortic peak pressure gradient1
Identification of safety margins for polysorbate 80 exposure in canines1
Improved detection of compound arrhythmogenicity in 2D cardiac stem cell models via advanced maturation strategies1
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins1
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits1
AI analysis in MEA data of hiPSC-derived neurons is useful method for risk prediction of pesticides1
Editorial Board1
Translational understanding of PDE4 inhibition1
Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats1
In vitro neurotoxicity testing using functional human iPSC-derived neurons1
Comparing the sensitivity of cross-over and parallel study designs for QTc assessment: An analysis based on a single large study of moxifloxacin in 48 nonhuman primates1
Ligand-binding assays validated for quantitative bioanalysis of a novel antibody-drug conjugate in monkey serum and related application in a nonclinical study1
Combining human-based in silico and in vitro models of inherited cardiac diseases for drug safety and efficacy evaluation1
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys1
A mouse model of allergic conjunctivitis permitting tear eosinophil quantification1
Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis1
Dosing in the dark—effect of time of dosing on preclinical safety profiles1
Determination of unbound platinum concentrations in human plasma using ultrafiltration and precipitation methods1
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™1
A novel murine model of pulmonary fibrosis: the role of platelets in chronic changes induced by bleomycin1
MEA assay with human iPSC-derived neurons generated by a rapid differentiation method1
Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies1
Preclinical safety pharmacology risk assessment for oligonucleotides put into practice1
Editorial Board1
Multiplexed structure-function assay for high throughput drug safety testing on human induced pluripotent stem cell-derived cardiomyocytes and neurons1
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction1
Test facility management: Responsibilities and paradigms of a new era1
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss1
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods1
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog0
Comparison of automated analysis methods for small animal activity assessment0
Evaluation of a left ventricular pressure catheterized rat telemetry model to measure cardiac contractility: Prevalence of post-surgical arrhythmias0
Application of rapid iPSC differentiation to neurotoxicity assays0
Cutibacterium acnes induces acne-like lesions in hairless mice models - A comparative study0
Demonstrating the statistical and pharmacological sensitivity of nonclinical QTc analysis using a dofetilide dose–response in nonhuman primates0
Potential for use of a flavone isolated from Chromolaena leivensis as anti-inflammatory drug0
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay0
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects0
Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma0
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma0
Safety pharmacology in 2022: Taking one small step for cardiovascular safety assay development but one giant leap for regulatory drug safety assessment0
Comparative assessment of Ca2+ oscillations in 2- and 3-dimensional hiPSC derived and isolated cortical neuronal networks0
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives0
Distinction of IKr blockers based on channel state preference using voltage clamp simulations and machine learning0
Virtual clinical QT exposure-response studies – A translational computational approach0
Optimization of bioanalysis of dried blood samples0
Voltage imaging of single contracting human iPSC-CMs using ratiometric voltage-sensitive dyes0
Preclinical mitigation of 5-HT2B agonism-related cardiac valvulopathy revisited0
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As0
Editorial Board0
Editorial Board0
Conduction liability of cardiac sodium channel binding sites0
Are drugs marketed nowadays more selective and safe than those approved 20 years ago?0
A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods0
Preclinical nerve conduction: Nerve battery options for primate studies0
Post-exercise hypotension induced by six-minutes walking test in dogs with naturally occurring mitral insufficiency0
Determination of five positive control drugs in hERG external solution (buffer) by LC-MS/MS to support in vitro hERG assay as recommended by ICH S7B0
The impact of environmental and biological factors on the resting heart rate of dogs as assessed using 20 years of data from safety pharmacology studies0
Alloxan as a better option than streptozotocin for studies involving painful diabetic neuropathy0
Unattended screening workflow in a 384-well automated patch clamp system0
The use of normative qEEG databases increases the accuracy of subject screening in phase I clinical trials of drugs with seizure liabilities0
Development, validation, and clinical application of a UPLC-MS/MS method for omadacycline determination in human serum0
QT Ratio: A simple solution to individual QT correction0
A case report of cardiovascular safety outcomes in mice supported by a pharmacodynamic biomarker0
Do behavioral test scores represent repeatable phenotypes of female mice?0
Detection of contractility changes in the heart from arterial blood pressure data using symmetric Projection Attractor Reconstruction0
Editorial Board0
Detecting immunotoxicity in vitro—clinically relevant studies in the COVID-19 era0
Quantification of anti-drug antibodies against E6011, an anti-fractalkine monoclonal antibody, in monkey and human serum, by an electrochemiluminescence assay0
Variations in neuron: Glia ratio may alter sensitivity to detect seizurogenic potential of drugs0
Evaluation of 4 quantification methods for monitoring 16 antidepressant drugs and their metabolites in human plasma by LC-MS/MS0
Compromising the immunogenicity of diphtheria toxin-based immunotoxins through epitope engineering: An in silico approach0
Validation of using cardioplegic solutions for preserving cardiac function in isolated rabbit heart assays0
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients0
Improved prediction of adverse drug reactions for loperamide and pramipexole with in vitro secondary pharmacology profiling panels0
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee0
The application of Bayesian forecasting to explore the effects of sex and high-fat diet on the pharmacokinetics of ropivacaine in the rat0
Editorial Board0
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients0
Assessment of antiemetic activity of dihydrocoumarin: In vivo and in silico approaches on receptor binding affinity and modulatory effects0
In silico study of drug effects on human non-failing and failing cardiomyocytes0
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation0
Optimization of a histamine-induced allergic conjunctivitis model in Guinea pigs0
Adverse effects of hydroxychloroquine and azithromycin on contractility and arrhythmogenicity revealed by human engineered cardiac tissues0
A retrospective analysis of the spontaneous incidence of neurological clinical signs across species0
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis0
Investigating the effects of mitochondrial inhibitors and uncoupler on hiPSC-CM MEA assay to predict drug-induced cardiotoxicity0
Drug combination assays using Caenorhabditis elegans as a model system0
The NaV1.5 late current in WT and Nav1.5-ΔKPQ mutant channels: An automated patch clamp LQT3 electrophysiological assay comparison0
Evoked responses to electrical stimulation in acute brain slice using a high-density and large-scale CMOS-MEA system0
Use of human Caco-2 cells and HPAE-PAD for α-glucosidase assay0
The 2-year rodent bioassay in drug and chemical carcinogenicity testing: Performance, utility, and configuration for cancer hazard identification0
A comparison of multiple left ventricular pressure endpoints as a screening tool in rats0
Assessing the reversibility of acetylcholinesterase (AChE) inhibitors0
Sensitive and rapid method for the quantitation of amoxicillin in minipig plasma and milk by LC-MS/MS: A contribution from the IMI ConcePTION project0
Comparative toxicity assessment of selected nanoparticles using different experimental model organisms0
Assessment of cardiac reserve and chronotropic effects using dobutamine stress echocardiography in healthy male rats0
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins0
Pressure-based estimation of right ventricular ejection fraction: Validation as a clinically relevant target for drug development in a rodent model of pulmonary hypertension0
Editorial Board0
CNS (EEG & behavior) safety assessment in freely moving/socially housed non-rodents0
Editorial Board0
Isolation and electrophysiological recording of Ixodes ricinus synganglion neurons0
Evaluation of chronic drug-induced effects of oncologic compounds on cardiac function and cardiac biomarkers release in human induced pluripotent stem cell-derived cardiomyocytes0
Biochemical characterization of high fat diet fed and low dose streptozotocin induced diabetic Wistar rat model0
A novel nonhuman primate model of citric acid-induced cough0
Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward0
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document0
Mouse models for actinic keratoses0
Inter-rater agreement between WHO- Uppsala Monitoring Centre system and Naranjo algorithm for causality assessment of adverse drug reactions0
Editorial Board0
Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy0
Intra-laboratory validation of yeast-based reporter gene assays for human thyroid hormone receptors0
Development and validation of a LC-MS/MS method for simultaneous quantification of Ivabradine and Metoprolol in rat plasma0
Analysis of secondary pharmacology assays received by the US Food and Drug Administration0
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay0
CiPA-compliant assessment of proarrhythmogenic risk for chloroquine and hydroxychloroquine0
Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity0
A generalized canine transfer function accurately reconstructs central aortic pressure waveforms to enable enhanced pulse wave analysis0
Evaluation of acute and long-term drug effects on contractility at 1 Hz electrical pacing with human induced pluripotent stem cell-derived cardiac cell sheet-tissues0
A method for assessing and monitoring consistency of nonclinical ECG analysis0
Cardiotoxicity with immune checkpoint inhibitors0
Doxorubicin-induced cardiotoxicity: Investigating the effect on miRNA expression and G-protein coupled receptors mediated vascular tone0
Editorial Board0
Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities0
Editorial Board0
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition0
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis0
Effects of omecamtiv mecarbil on calcium-transients and contractility in a translational canine myocyte model0
Rodent model in safety pharmacology to evaluate effects of learning and memory properties of a drug0
Solvents effect on dansyl cysteamine depletion and reactivity classification of skin sensitizers: Tackling the challenges using binary solvent systems0
Safety pharmacology during the COVID pandemic0
Measuring the impact of known inotropes on rat papillary muscles via the force-clamped feedback work-loop0
The electrophysiological responses to antibacterial drugs in human iPSC-derived neurons demonstrate the classification of antibacterial drug encephalopathy clinically0
Drug effects on human Na+/Ca2+ exchanger and implications for testing new drug candidates0
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