Journal of Pharmacological and Toxicological Methods

Article	Citations
Editorial Board	35
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	32
Quantitative comparison of ECG limb lead configurations: Evaluating synonymity of interval measurements using alternative leads under appropriately controlled study conditions	25
Off-target of a novel TYK2 inhibitor is associated with myocardial necrosis mediated by hemodynamic changes in rats	21
Reproducible safety pharmacology echocardiography studies in vehicle-treated canines and NHPs	21
Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform	20
Organelle profiling of compound-induced effects in human iPSC-derived cardiomyocytes in combination with electrophysiology assays for in vitro prediction of cardiac safety	18
The impact of collaborative science on cardiovascular safety evaluation – A 10-year update of the HESI cardiac safety committee	17
Assessment of abuse liability and respiratory effects of mitragynine and 7-hydroxymitragynine in rats	16
A retrospective analysis of the concordance between cardiovascular effects in telemetry studies, toxicity studies, and early clinical trials	15
Corrigendum to ‘PolyCheck: A hybrid model for predicting polypharmacy-induced adverse drug reactions in tuberculosis treatment using heterogenous drug-target-ADR networks’ [Journal of pharmacological	15
Contractility assessment using aligned human iPSC-derived cardiomyocytes	12
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	12
Metabolomics using high-resolution magic angle spinning nuclear magnetic resonance: Neurotoxicological applications	12
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	12
Ciprofloxacin does not accelerate aortic stiffness or aortic dilation in healthy, hypertensive and diseased mouse models	11
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	11
hiPSC-derived neurons and multi-electrode array (MEA): Powerful tools within safety pharmacology for identifying the CNS modifying effects of compounds targeting ligand- and voltage-gated ion channels	11
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	11
Investigation of in vitro I /hERG assays under physiological temperature conditions using the semi-automated patch-clamp system QPatch compact with temperature control system	10
Effects of temperature, compound concentration verification, and internal fluoride on hERG	9
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	9
Retrospective review of the safety pharmacology assessment of emerging therapeutic modalities approved from 2010 to 2023	9
Enhanced detection sensitivity in nonclinical cardiovascular telemetry studies: Impact of a characterized facility	9
Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation	9

The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	9
Enhanced interpretation of secondary pharmacology data through automated visualization tools to support safety assessment	9
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	9
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease	8
Development of electrophysiological toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	8
Advances in microfluidic endothelium-on-chip for assessing endothelial function	8
An investigation into the relationship between acetazolamide systemic exposure, blood gas changes and ventilatory parameters in the sprague Dawley® rat	8
Effect of telemetry study design on minimum detectable difference values for QTc interval	8
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™	8
Monitoring cardiomyocyte function with hybrid EFP-impedance technology for drug safety evaluation	8
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration	8
Comparisons of hERG data for 30 drugs generated by automated and manual patch clamp systems by the same laboratory	7
Analyzing atrial human iPSC-cardiomyocyte responses to GPCR and ion channel modulators: Introducing a chamber-specific cell model for preclinical testing	7
Evaluation of the J-Tpeak and Tpeak-to-tend intervals of the ECG as proarrhythmia biomarkers in telemetered dogs	7
Comparison of quinine-induced QRS prolongation in canine and primate telemetry studies: Applying concentration-effect modeling to assess ventricular conduction delay risk	7
Minimal requirements for stem-cells derived cardiomyocytes and MEA usage in view of field potential analysis by reverse modeling - A theoretical study on the impact of 3 variability factors	6
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone	6
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain	6
Gene therapy: A different challenge for toxicologists?	6
Streamlined dispersive solid phase extraction for determination of amitriptyline, cocaine, and benzoylecgonine in urine	6
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology	6
Non-invasive monitoring of cardiac output: Validation in anesthetized laboratory rats by pharmacological beta-adrenergic pathway modulation	6
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits	6
Analytical method development for detection and quantification of AMB-FUBINACA in mouse brain tissue using GC–MS/MS	5
The translation of hERG block and APD90 in vitro to clinical QTc prolongation in man	5
Regulatory safety pharmacology & toxicology assessment studies: Measurement of the ECG and hemodynamic parameters in non-rodent species	5
Exploratory safety investigations in normal, freely moving Göttingen Minipigs using telemetry: Pharmacological validation	5
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys	5
Are current rat studies sensitive to detect blood pressure changes per the new FDA draft clinical blood pressure guidance?	5
In silico modeling of hemodynamic and autonomic effects of a selective α2-adrenoceptor agonist in beagle dogs by telemetry	5
Editorial Board	5
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	5
QT Ratio: A simple solution to individual QT correction	5
Taking a deep breath: Evidence-based approaches to respiratory safety assessment	5
Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies	5
Analytical performance of poly(L-cysteine) modified pencil graphite electrode for dapsone detection	5
Editorial Board	5
Non-clinical cardiovascular safety testing: Current status, gaps and emerging trends	4
Establishment of high-throughput toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	4
Establishment of functional observational battery test in large animals (dogs and non-human primates)	4
In silico modeling of effects of pimobendan on cardiac output and systemic vascular resistance in beagle dogs by telemetry	4
Serum starvation magnifies the delayed suppression of IK by probucol	4
Recording of transcellular voltage deflections from cardiomyocytes on MEA devices using laser poration	4
Improving on-tissue detection of doxorubicin by using matrix assisted laser desorption ionization mass spectrometry imaging	4
An in silico approach during safety pharmacology studies	4
Using automated patch clamp for high throughput pharmacological characterization of cardiac action potentials	4
Evaluation of the head twitch response in male C57BL/6J mice as a measure of 5-HT receptor activation	4
Development of spectroscopic methods using charge transfer complex for the quantitative estimation of proguanil hydrochloride: Insights from greenness evaluation, BSA binding, molecular docking, antim	3
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog	3
High-throughput evaluation of cardiac electrophysiology and predicted actions on cardiac ion channels using hiPSC-CM and MEA technology	3

Assessing the cardiotoxicity of 31 compounds using a multiplexed kinetic image cytometry (KIC)-based assay: Harnessing the predictive power of human iPSC-cardiomyocytes for early drug development	3
Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans	3
A retrospective review of the effects of moxifloxacin in NHP at four different test sites	3
Study to compare effects of a positive inotrope administered concurrently with a beta-blocker in ventricular Tachy-Paced dogs in mild heart failure	3
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	3
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis	3
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	3
Editorial Board	3
Variability of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices	3
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay	3
Enhancing cardiac safety evaluation: Assessing drug interactions with the late Nav1.5 current	3
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	3
Development of a novel milli-fluidic liver tissue chip for mechanistic drug-induced liver injury (DILI) studies	2
Multi-site validation of in vivo QT ICH E14/S7B Q&A guidance in canines and non-human primates	2
Editorial Board	2
Correlation electrical repolarization and membrane hERG abundance in iPSC cardiomyocytes induced by chronic drugs actions on channel trafficking	2
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	2
Elucidating the challenges with categorizing drugs that block cardiac sodium channels − The impact of temperature on drug-cardiac sodium channel interactions	2
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	2
Discovery and development of digital biomarkers to inform home-cage neuro-behavioral assessments in the rodent	2
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	2
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee	2
Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity	2
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	2
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients	2
Dog and minipig telemetry assay sensitivity to detect QTc prolongation: Moxifloxacin effects by timepoint and concentration-QTc relationship analysis	2
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients	2
QTc least significant difference in stand-alone implanted telemetry safety pharmacology and jacketed external telemetry regulatory toxicology studies in dogs	2
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods	2
Spectrum of effects detected in the rat functional observational battery following administration of non-CNS targeted and CNS targeted compounds	2
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	2
State-of-the-art in secondary pharmacology and its impact on the safety of new medicines	2
Lipopolysaccharide-induced abdominal nociception behavioral model in adult zebrafish (Danio rerio)	2
Therapeutic drug monitoring of busulfan and cyclophosphamide in hematologic malignancies: An LC-MS/MS development, validation and application	2
Long-term monitoring of cardiac action potentials for the assessment of chronic cardiotoxicity	2
Rapid quantification of CSF total protein via smartphone digital colorimetry: Enabling early diagnosis of central nervous system diseases	2
Combining a systems immunology approach with in vitro data to evaluate drug-induced changes in the immune response after Influenza A Virus infection – A blueprint for the preclinical assessment of inf	2
Cardiac 3D electromechanical tissue simulations for cardiac safety analysis	2
ICH E14/S7B Q&A integrated risk assessment: Strategies for managing TQT waivers if S7B non-clinical studies don't meet best practice expectations	2
Development of a pharmaceutical database to support the nonclinical evaluation of drug-induced cardiac toxicity	2
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	2
Current practices on the measurement of electrocardiogram and hemodynamic parameters in non–rodent species in regulatory safety assessment studies	2
A translational study between human induced pluripotent stem cell-derived cardiomyocytes (Hipsc-Cm) and an in vivo model to predict proarrhythmogenic properties	2
In silico predictions of drug-induced changes on cardiac contractility in human ventricular cardiomyocytes	2
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	2
Virtual clinical QT exposure-response studies – A translational computational approach	2
Heart rate corrected JTp and TpTe as proarrhythmia biomarkers in safety pharmacology non-human primate studies: Outcome from a HESI consortium prospective study	1
Recommendations on the measurement of electrocardiogram and hemodynamic parameters in restrained non-rodent species in regulatory safety assessment studies	1
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	1
Action potential recordings from air-shipped adult human primary cardiomyocytes	1
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	1
Editorial Board	1
Editorial Board	1
Evaluation of laser optoporation-induced action-potential-like measurements on iPSC-cardiomyocytes and the assessment of drug-induced effects on APD and contractility	1
Non-invasive, home cage digital monitoring for improved safety pharmacology assessments in drug development: ICH S7A update considerations	1
Long-term inhibition of PI3K/Akt signaling by amiodarone augments late sodium current in CHO cells and hiPSC-CMs	1
Intravenous self-administration in the rat: Advantage of transcutaneous buttons for improving the animal welfare	1
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	1
Cardiac injury miRNA profile in breast cancer patients treated with left-sided radiotherapy	1
Editorial Board	1
Pharmacological assessments of NaV1.5 and hERG channel blockers in AV-ablated isolated rabbit heart assay under varying heart rates and temperatures	1
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	1
A retrospective review of the effects of moxifloxacin in dogs at four different test sites	1
Angiotensin II as a linking factor in cardiovascular disease enhanced cancer growth	1
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction	1
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects	1
Adding artificial arrhythmias during training boosts the performance of neuronal networks for arrhythmia detection	1
Chemometrics-assisted spectrophotometric method for the simultaneous determination of phenylephrine hydrochloride, chlorpheniramine maleate and paracetamol	1
Fun with pharmacology: Evaluating stresses on the system using the core battery	1
Compound A, a novel dual mu and kappa opioid receptor agonist that exerts potent an analgesic effect comparable to oxycodone, showed no reinforcing effect in monkeys	1
WITHDRAWN: Simultaneous quantification of venetoclax, busulfan and voriconazole in plasma by LC-MS/MS: clinical applications in patients with acute myeloid leukemia	1
An evaluation of detection sensitivity and pharmacokinetic profile for conscious telemetered cynomolgus monkeys	1
A comparative study of kidney lithogenic agents in Wistar rats by invasive and noninvasive methods	1
PolyCheck: A hybrid model for predicting polypharmacy-induced adverse drug reactions in tuberculosis treatment using heterogenous drug-target-ADR networks	1
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies with alternative study designs in non-rodent species	1
Toxicology and safety pharmacology investigations on the nervous system: 2024 industry survey	1
Test facility management: Responsibilities and paradigms of a new era	1
A state-of-the-art method for high-throughput, automated locomotor activity testing in neuropharmacology, safety, and toxicology studies	1
Characterization of a human wearable ECG device for continuous in-cage data collection in non-rodents	1
Rodent models of anxiety and compulsion: When multiple endpoints add value	1

The role of the central amygdala in threat response in a semi-natural environment	1
Predicting thorough QT safety profile using hERG IC10 versus IC50	1
Editorial Board	1
An ex vivo zebrafish heart model for oxidative stress studies	1
Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward	1
Astrocyte responses to seizurogenic compounds using MEA	1
Detecting drug-induced EEG alterations with machine learning: A methodological proof-of-concept study in rats treated with MK-801	1
In vitro systems for the assessment of chronic cardiotoxic effects: News from the HESI stem cell working group	1
An accurate and reproducible method to measure snake venom anticoagulant activity	1
Inter-rater agreement between WHO- Uppsala Monitoring Centre system and Naranjo algorithm for causality assessment of adverse drug reactions	1
Improved translation of Nav1.5 channel inhibition to in vivo QRS interval prolongation via the hIPSC cardiomyocyte model	1
Snapshot versus continuous analysis of respiratory parameters collected by whole body plethysmography following oral administration of caffeine and baclofen in conscious unrestrained rats	1
Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel	1
Using cultured human myocardial tissue slices to test cardiotoxic effects	1
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay	1
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys	1
Categorizing TdP risk with qNet: Effects of protocol design on HERG models and TMS outcomes	1
High-content cell imaging for chemical toxicity screening in the model organism Caenorhabditis elegans	1
Drug combination assays using Caenorhabditis elegans as a model system	1
The translation of QTc across species - Impact of subject number and exposure multiple tested on discriminatory sensitivity	1
StemRNA iPSC-derived human ventricular cardiac tissue (iHCT) for safety pharmacology assessment	1
Physiologically relevant in vitro endothelial model for studying drug-induced vascular injury	0
Editorial Board	0
Changes in the nerve conduction (NC) of juvenile rodents due to maturation with implications for preclinical evaluation of toxic neuropathies	0
Safety Pharmacology: Achieving a quarter century milestone as a scientific discipline	0
Development of a label-free cytotoxicity assay for dose response analysis	0
Video-based detection of pentylenetetrazol induced severe convulsions in cynomolgus monkeys	0
Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis	0
Development of drug toxicity evaluation platform using hiPSC-derived cardiac organoids	0
Artificial intelligence-based phenotypic characterization of gender-specific, patient – iPSC derived cardiomyocyte cell models	0
Revisiting the high-fat diet/low streptozotocin prediabetic rat model: A bioanalytical adjustment	0
Optimization of bioanalysis of dried blood samples	0
Exploratory continuous interstitial glucose monitoring using the FreeStyle Libre 2 device in cynomolgus monkeys	0
Simultaneous quantification of thalidomide, lenalidomide and pomadomide in plasma by LC-MS/MS	0
Physiologic corrections for ECG intervals beyond QT	0
High throughput automated patch-clamp of cardiac ion channels using physiological fluoride-free internal solution	0
OCT2 in the heart and GAT1 in the brain: Functional characterization and drug development using SSM-based electrophysiology	0
Application for drug evaluation of human-induced pluripotent stem cell-derived cardiomyocytes cultured by anisotropic orientation	0
A simple, accurate method for defining concentration-QTc in animals	0
Analysis of secondary pharmacology assays received by the US Food and Drug Administration	0
Evaluation of the sensitivity/specificity of statistical analysis strategies for detecting moxifloxacin-induced QTc prolongation	0
Redefining cardiovascular safety: A dual-pathway, mechanistic in silico screen for the detection of trafficking-mediated and “hidden” cardiotoxicity	0
JET, but not ‘snapshot’, analysis is sensitive enough to detect effects at critical concentrations of ondansetron and moxifloxacin in dog	0
Editorial Board	0
Prediction of postural hypotension in humans from α -adrenoceptor binding data using secondary intelligence™	0
Anticoagulant activity of Eucalyptus essential oils: An in vitro approach and a bioinformatics-based pharmacokinetic-pharmacodynamic analysis	0
Supporting an integrated QTc risk assessment using the hERG margin distributions for three positive control agents derived from multiple laboratories and on multiple occasions.	0
Corrigendum to “Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As” [J. Pharm	0
Effects of high-fat diet and nutraceutical resveratrol on maximal force, power and fatigue resistance of skeletal muscle	0
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B6	0
In vitro assessment of long-term cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes	0
An optimized method for intratracheal instillation in mice	0
Functional observation battery (FOB)/Irwin integrated in general toxicology studies: A retrospective analysis	0
The application of Bayesian forecasting to explore the effects of sex and high-fat diet on the pharmacokinetics of ropivacaine in the rat	0
A characterization of aficamten, a cardiac myosin inhibitor, in core battery safety pharmacology studies	0
Adaptation of closed-chest infarction porcine model to adult Pannon minipigs	0
An iPSC-derived neurotoxicity screening platform demonstrates compound toxicity on calcium activity, synapses, viability and cell proliferation	0
Development of a high-throughput system for advanced functional cell analysis to predict safety	0
Telemetry in toxicology studies – A comparison of data across species, technologies and time	0
Evaluating mitochondrial dysfunction and hepatotoxicity in HUREL micro liver co-cultures	0
Panelizing secondary pharmacology profiling against key safety liabilities to further impact drug development	0
The 2023 Safety Pharmacology Society (SPS) salary survey	0
Editorial Board	0
Quantitative framework for using in vitro hERG IC s to support integrated nonclinical risk assessment for the new ICH E14/S7B Q&As	0
Preclinical mitigation of 5-HT2B agonism-related cardiac valvulopathy revisited	0
High-throughput drug screening of 3D hiPSC cardiac microtissues with inherited arrhythmia disorders to identify novel therapeutic compounds	0
From surplus to scientific value: Repurposing vascular tissues for organ bath standardization to de-risk vasoactive liabilities	0
Effects of fentanyl on respiratory and cardiovascular systems in telemetered monkeys	0
Characterization of a human wearable ECG device for continuous data collection in freely moving non-rodents	0
Chronic assessment of hERG trafficking on repolarisation and cytotoxicity in iPSC cardiomyocytes	0
The emerging use of artificial intelligence in safety pharmacology and toxicology	0
Amphetamine, methamphetamine, and MDMA in hair samples from a rehabilitation facility: Validation and applicability of HF-LPME-GC-MS	0
Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration	0
ICH S7B hERG and cardiac repolarization assays do not address mechanisms of QT prolongation for peptide and protein products	0
HERG block in HEK cells incorporated in real time into computer models of in silico cardiac repolarization using dynamic clamp	0
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute	0
Contractility-based pharmacological characterization of hiPSC-derived atrial and ventricular cardiomyocytes assessed on the FLEXcyte 96	0
Phenylthiourea-mediated experimental depigmentation reduces seizurogenic response of pentylenetetrazol in zebrafish larva	0
Assay development and validation to measure contraction force from co-culture of human iPSC-derived cardiomyocytes and cardiac fibroblasts on the FLEXcyte 96 system	0
From cellular waste to biomarkers; insights into past, present, and future methods to detect immune cell-derived extracellular vesicles using flow cytometry	0
Regulatory feedback on drug discrimination studies for a small molecule with a novel mechanism of action	0
Cardiovascular assessment of lipid nanoparticle-encapsulating mRNA therapeutics in rats using telemetry and Star-Oddi logger devices	0
Cardiovascular effects of Zenalpha® compared to dexmedetomidine in ventricular tachy-paced dogs	0
From neat compounds to complex mixtures: A potential screening strategy for cardiotoxic potential of botanicals	0
Comparative toxicity assessment of selected nanoparticles using different experimental model organisms	0
Intravenous self-administration – Valid experimental designs to evaluate the abuse potential of psychedelics, entactogens and drugs with novel mechanisms	0
Analysis of baroreflex and heart rate variability – Tools in cardiovascular pre-clinical safety studies	0
A simple accurate method for concentration-QTc analysis in preclinical animal models	0
Compromising the immunogenicity of diphtheria toxin-based immunotoxins through epitope engineering: An in silico approach	0
Editorial Board	0
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment	0
Assessment moxifloxacin-induced QTc prolongation in canine and nonhuman primate using a linear mixed effect modeling approach	0
High-throughput assessment of cardiac safety via calcium and voltage imaging of 3D engineered heart tissues and 2D cell cultures using a novel instrumentation platform	0
Reference intervals for electrocardiograms and arrhythmia incidence in healthy, sedated cynomolgus macaques	0
Surgical instrumentation for concomitant systemic blood pressure and blood sampling in healthy rabbits	0