Journal of Pharmacological and Toxicological Methods

Article	Citations
A retrospective analysis of the concordance between cardiovascular effects in telemetry studies, toxicity studies, and early clinical trials	30
Quantitative comparison of ECG limb lead configurations: Evaluating synonymity of interval measurements using alternative leads under appropriately controlled study conditions	29
Metabolomics using high-resolution magic angle spinning nuclear magnetic resonance: Neurotoxicological applications	27
Off-target of a novel TYK2 inhibitor is associated with myocardial necrosis mediated by hemodynamic changes in rats	23
Reproducible safety pharmacology echocardiography studies in vehicle-treated canines and NHPs	20
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	19
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	18
Chronic bladder catheterization for precise urine collection in awake mice	15
Editorial Board	15
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	14
Contractility assessment using aligned human iPSC-derived cardiomyocytes	13
Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform	12
The impact of collaborative science on cardiovascular safety evaluation – A 10-year update of the HESI cardiac safety committee	11
Assessment of abuse liability and respiratory effects of mitragynine and 7-hydroxymitragynine in rats	11
Organelle profiling of compound-induced effects in human iPSC-derived cardiomyocytes in combination with electrophysiology assays for in vitro prediction of cardiac safety	11
Corrigendum to ‘PolyCheck: A hybrid model for predicting polypharmacy-induced adverse drug reactions in tuberculosis treatment using heterogenous drug-target-ADR networks’ [Journal of pharmacological	11
Drug-target interaction prediction using reliable negative samples and effective feature selection methods	11
hiPSC-derived neurons and multi-electrode array (MEA): Powerful tools within safety pharmacology for identifying the CNS modifying effects of compounds targeting ligand- and voltage-gated ion channels	10
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	10
Ciprofloxacin does not accelerate aortic stiffness or aortic dilation in healthy, hypertensive and diseased mouse models	10
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	10
Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation	9
Enhanced interpretation of secondary pharmacology data through automated visualization tools to support safety assessment	9
Retrospective review of the safety pharmacology assessment of emerging therapeutic modalities approved from 2010 to 2023	9
Enhanced detection sensitivity in nonclinical cardiovascular telemetry studies: Impact of a characterized facility	9

Development of electrophysiological toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	8
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	8
Effects of temperature, compound concentration verification, and internal fluoride on hERG	8
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration	8
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	8
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	8
Effect of telemetry study design on minimum detectable difference values for QTc interval	8
Investigation of in vitro I /hERG assays under physiological temperature conditions using the semi-automated patch-clamp system QPatch compact with temperature control system	8
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease	7
Comparison of quinine-induced QRS prolongation in canine and primate telemetry studies: Applying concentration-effect modeling to assess ventricular conduction delay risk	7
Monitoring cardiomyocyte function with hybrid EFP-impedance technology for drug safety evaluation	7
Comparisons of hERG data for 30 drugs generated by automated and manual patch clamp systems by the same laboratory	7
Analyzing atrial human iPSC-cardiomyocyte responses to GPCR and ion channel modulators: Introducing a chamber-specific cell model for preclinical testing	7
Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies	7
Evaluation of the J-Tpeak and Tpeak-to-tend intervals of the ECG as proarrhythmia biomarkers in telemetered dogs	7
An investigation into the relationship between acetazolamide systemic exposure, blood gas changes and ventilatory parameters in the sprague Dawley® rat	7
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models	6
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™	6
Minimal requirements for stem-cells derived cardiomyocytes and MEA usage in view of field potential analysis by reverse modeling - A theoretical study on the impact of 3 variability factors	6
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	6
Non-invasive monitoring of cardiac output: Validation in anesthetized laboratory rats by pharmacological beta-adrenergic pathway modulation	6
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone	6
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits	6
Gene therapy: A different challenge for toxicologists?	6
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain	5
The translation of hERG block and APD90 in vitro to clinical QTc prolongation in man	5
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology	5
Taking a deep breath: Evidence-based approaches to respiratory safety assessment	5
In silico modeling of hemodynamic and autonomic effects of a selective α2-adrenoceptor agonist in beagle dogs by telemetry	5
Are current rat studies sensitive to detect blood pressure changes per the new FDA draft clinical blood pressure guidance?	5
Using automated patch clamp for high throughput pharmacological characterization of cardiac action potentials	4
In silico modeling of effects of pimobendan on cardiac output and systemic vascular resistance in beagle dogs by telemetry	4
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	4
Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies	4
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	4
Serum starvation magnifies the delayed suppression of IK by probucol	4
Recording of transcellular voltage deflections from cardiomyocytes on MEA devices using laser poration	4
Improving on-tissue detection of doxorubicin by using matrix assisted laser desorption ionization mass spectrometry imaging	4
Enhancing cardiac safety evaluation: Assessing drug interactions with the late Nav1.5 current	4
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys	4
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis	4
Regulatory safety pharmacology & toxicology assessment studies: Measurement of the ECG and hemodynamic parameters in non-rodent species	4
Establishment of functional observational battery test in large animals (dogs and non-human primates)	4
Evaluation of the head twitch response in male C57BL/6J mice as a measure of 5-HT receptor activation	4
Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans	4
An in silico approach during safety pharmacology studies	4
QT Ratio: A simple solution to individual QT correction	4
Exploratory safety investigations in normal, freely moving Göttingen Minipigs using telemetry: Pharmacological validation	4
Editorial Board	4
Establishment of high-throughput toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	4

Multi-site validation of in vivo QT ICH E14/S7B Q&A guidance in canines and non-human primates	3
Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity	3
A retrospective review of the effects of moxifloxacin in NHP at four different test sites	3
Development of a novel milli-fluidic liver tissue chip for mechanistic drug-induced liver injury (DILI) studies	3
Variability of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices	3
Assessing the cardiotoxicity of 31 compounds using a multiplexed kinetic image cytometry (KIC)-based assay: Harnessing the predictive power of human iPSC-cardiomyocytes for early drug development	3
Non-clinical cardiovascular safety testing: Current status, gaps and emerging trends	3
Dog and minipig telemetry assay sensitivity to detect QTc prolongation: Moxifloxacin effects by timepoint and concentration-QTc relationship analysis	3
Combining a systems immunology approach with in vitro data to evaluate drug-induced changes in the immune response after Influenza A Virus infection – A blueprint for the preclinical assessment of inf	3
High-throughput evaluation of cardiac electrophysiology and predicted actions on cardiac ion channels using hiPSC-CM and MEA technology	3
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	3
Cardiac 3D electromechanical tissue simulations for cardiac safety analysis	3
Study to compare effects of a positive inotrope administered concurrently with a beta-blocker in ventricular Tachy-Paced dogs in mild heart failure	3
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee	3
Long-term monitoring of cardiac action potentials for the assessment of chronic cardiotoxicity	3
Elucidating the challenges with categorizing drugs that block cardiac sodium channels − The impact of temperature on drug-cardiac sodium channel interactions	2
Current practices on the measurement of electrocardiogram and hemodynamic parameters in non–rodent species in regulatory safety assessment studies	2
Discovery and development of digital biomarkers to inform home-cage neuro-behavioral assessments in the rodent	2
Virtual clinical QT exposure-response studies – A translational computational approach	2
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients	2
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay	2
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	2
In silico predictions of drug-induced changes on cardiac contractility in human ventricular cardiomyocytes	2
Correlation electrical repolarization and membrane hERG abundance in iPSC cardiomyocytes induced by chronic drugs actions on channel trafficking	2
QTc least significant difference in stand-alone implanted telemetry safety pharmacology and jacketed external telemetry regulatory toxicology studies in dogs	2
Spectrum of effects detected in the rat functional observational battery following administration of non-CNS targeted and CNS targeted compounds	2
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	2
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	2
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients	2
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog	2
Editorial Board	2
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	2
ICH E14/S7B Q&A integrated risk assessment: Strategies for managing TQT waivers if S7B non-clinical studies don't meet best practice expectations	2
Lipopolysaccharide-induced abdominal nociception behavioral model in adult zebrafish (Danio rerio)	2
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	2
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	2
Editorial Board	2
Therapeutic drug monitoring of busulfan and cyclophosphamide in hematologic malignancies: An LC-MS/MS development, validation and application	2
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	2
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	2
State-of-the-art in secondary pharmacology and its impact on the safety of new medicines	2
A translational study between human induced pluripotent stem cell-derived cardiomyocytes (Hipsc-Cm) and an in vivo model to predict proarrhythmogenic properties	2
Categorizing TdP risk with qNet: Effects of protocol design on HERG models and TMS outcomes	1
Using cultured human myocardial tissue slices to test cardiotoxic effects	1
A method for assessing and monitoring consistency of nonclinical ECG analysis	1
Chemometrics-assisted spectrophotometric method for the simultaneous determination of phenylephrine hydrochloride, chlorpheniramine maleate and paracetamol	1
Test facility management: Responsibilities and paradigms of a new era	1
Snapshot versus continuous analysis of respiratory parameters collected by whole body plethysmography following oral administration of caffeine and baclofen in conscious unrestrained rats	1
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	1
Editorial Board	1
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	1
The translation of QTc across species - Impact of subject number and exposure multiple tested on discriminatory sensitivity	1
The role of the central amygdala in threat response in a semi-natural environment	1
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods	1
A new approach for purification of the catalytic site of the angiotensin-conversion enzyme, N-domain, mediated by the ELP-Intein system	1
Compound A, a novel dual mu and kappa opioid receptor agonist that exerts potent an analgesic effect comparable to oxycodone, showed no reinforcing effect in monkeys	1
Off-target pharmacological activity at various kinases: Potential functional and pathological side effects	1
Evaluation of laser optoporation-induced action-potential-like measurements on iPSC-cardiomyocytes and the assessment of drug-induced effects on APD and contractility	1
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	1
A state-of-the-art method for high-throughput, automated locomotor activity testing in neuropharmacology, safety, and toxicology studies	1
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies with alternative study designs in non-rodent species	1
Cardiac injury miRNA profile in breast cancer patients treated with left-sided radiotherapy	1
PolyCheck: A hybrid model for predicting polypharmacy-induced adverse drug reactions in tuberculosis treatment using heterogenous drug-target-ADR networks	1
A retrospective review of the effects of moxifloxacin in dogs at four different test sites	1
Angiotensin II as a linking factor in cardiovascular disease enhanced cancer growth	1
High-content cell imaging for chemical toxicity screening in the model organism Caenorhabditis elegans	1
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	1
Editorial Board	1
Rodent models of anxiety and compulsion: When multiple endpoints add value	1
Development of a pharmaceutical database to support the nonclinical evaluation of drug-induced cardiac toxicity	1
An evaluation of detection sensitivity and pharmacokinetic profile for conscious telemetered cynomolgus monkeys	1
Preclinical nerve conduction: Nerve battery options for primate studies	1
In vitro systems for the assessment of chronic cardiotoxic effects: News from the HESI stem cell working group	1
A comparative study of kidney lithogenic agents in Wistar rats by invasive and noninvasive methods	1
Pharmacological assessments of NaV1.5 and hERG channel blockers in AV-ablated isolated rabbit heart assay under varying heart rates and temperatures	1
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction	1
Toxicology and safety pharmacology investigations on the nervous system: 2024 industry survey	1
Intravenous self-administration in the rat: Advantage of transcutaneous buttons for improving the animal welfare	1
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	1
Long-term inhibition of PI3K/Akt signaling by amiodarone augments late sodium current in CHO cells and hiPSC-CMs	1

Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel	1
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay	1
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys	1
Editorial Board	1
Characterization of a human wearable ECG device for continuous in-cage data collection in non-rodents	1
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	1
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	1
Improved translation of Nav1.5 channel inhibition to in vivo QRS interval prolongation via the hIPSC cardiomyocyte model	1
Editorial Board	1
Drug combination assays using Caenorhabditis elegans as a model system	1
Editorial Board	1
An optimized method for intratracheal instillation in mice	0
Quantitative framework for using in vitro hERG IC s to support integrated nonclinical risk assessment for the new ICH E14/S7B Q&As	0
A simple, accurate method for defining concentration-QTc in animals	0
From neat compounds to complex mixtures: A potential screening strategy for cardiotoxic potential of botanicals	0
Physiologic corrections for ECG intervals beyond QT	0
High throughput automated patch-clamp of cardiac ion channels using physiological fluoride-free internal solution	0
Regulatory feedback on drug discrimination studies for a small molecule with a novel mechanism of action	0
Characterization of a human wearable ECG device for continuous data collection in freely moving non-rodents	0
Functional observation battery (FOB)/Irwin integrated in general toxicology studies: A retrospective analysis	0
Preclinical mitigation of 5-HT2B agonism-related cardiac valvulopathy revisited	0
High-throughput drug screening of 3D hiPSC cardiac microtissues with inherited arrhythmia disorders to identify novel therapeutic compounds	0
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells	0
Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration	0
Physiologically relevant in vitro endothelial model for studying drug-induced vascular injury	0
SmartHeart: An innovative high throughput assay to generate and assess cardiac micro tissues from hiPSCs answering to the current challenges of drug discovery	0
Amphetamine, methamphetamine, and MDMA in hair samples from a rehabilitation facility: Validation and applicability of HF-LPME-GC-MS	0
Comparative toxicity assessment of selected nanoparticles using different experimental model organisms	0
Drug-induced cardiac contractility alterations: A comparative study between 2D and 3D models	0
Innovative approaches to cardiovascular safety pharmacology assessment	0
Supporting an integrated QTc risk assessment using the hERG margin distributions for three positive control agents derived from multiple laboratories and on multiple occasions.	0
Editorial Board	0
Historical control data of nonclinical nerve conduction parameters in nonhuman primates	0
Development of drug toxicity evaluation platform using hiPSC-derived cardiac organoids	0
Exploratory continuous interstitial glucose monitoring using the FreeStyle Libre 2 device in cynomolgus monkeys	0
Association between gastrointestinal effects in rodent toxicity studies and decreased locomotor activity in rodent safety pharmacology studies	0
Development of a label-free cytotoxicity assay for dose response analysis	0
Establishment of a new nonalcoholic steatohepatitis model; Ovariectomy exacerbates nonalcoholic steatohepatitis-like pathology in diabetic rats	0
The 2023 Safety Pharmacology Society (SPS) salary survey	0
A characterization of aficamten, a cardiac myosin inhibitor, in core battery safety pharmacology studies	0
Compromising the immunogenicity of diphtheria toxin-based immunotoxins through epitope engineering: An in silico approach	0
Cardiovascular effects of Zenalpha® compared to dexmedetomidine in ventricular tachy-paced dogs	0
Analysis of secondary pharmacology assays received by the US Food and Drug Administration	0
Evaluating mitochondrial dysfunction and hepatotoxicity in HUREL micro liver co-cultures	0
Panelizing secondary pharmacology profiling against key safety liabilities to further impact drug development	0
OCT2 in the heart and GAT1 in the brain: Functional characterization and drug development using SSM-based electrophysiology	0
A simple accurate method for concentration-QTc analysis in preclinical animal models	0
Prediction of postural hypotension in humans from α -adrenoceptor binding data using secondary intelligence™	0
Intratracheal administration of solutions in mice; development and validation of an optimized method with improved efficacy, reproducibility and accuracy	0
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B6	0
Standardizing high-throughput RNA extraction: Modifying commercial kits for improved purity, yield, and efficiency	0
Improving the in Vivo QTc assay: The value of implementing best practices to support an integrated nonclinical-clinical QTc risk assessment and TQT substitute	0
Effects of high-fat diet and nutraceutical resveratrol on maximal force, power and fatigue resistance of skeletal muscle	0
Application for drug evaluation of human-induced pluripotent stem cell-derived cardiomyocytes cultured by anisotropic orientation	0
Emerging neurology safety biomarkers for advanced modality therapeutic-associated neurotoxicity in nonhuman primates	0
In vitro assessment of long-term cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes	0
Adaptation of closed-chest infarction porcine model to adult Pannon minipigs	0
Improving information extraction from non-rodent telemetry-based cardiovascular toxicological studies by using advanced statistical techniques	0
Variability of manual patch clamp data on Ca 1.2 and Na 1.5 channels generated using standardized protocols and following ICH S7B Q&A 2.1 best practices – Progress update of a HESI-coordinated mul	0
Contractility-based pharmacological characterization of hiPSC-derived atrial and ventricular cardiomyocytes assessed on the FLEXcyte 96	0
Editorial Board	0
Corrigendum to “Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As” [J. Pharm	0
The application of Bayesian forecasting to explore the effects of sex and high-fat diet on the pharmacokinetics of ropivacaine in the rat	0
HERG block in HEK cells incorporated in real time into computer models of in silico cardiac repolarization using dynamic clamp	0
Advancing personalised treatment selection for atrial fibrillation: An in silico approach	0
Editorial Board	0
Evaluating a non-invasive telemetry jacket as an alternative to the reference methods for cardio-respiratory safety pharmacological testing in rats	0
Phenylthiourea-mediated experimental depigmentation reduces seizurogenic response of pentylenetetrazol in zebrafish larva	0
An iPSC-derived neurotoxicity screening platform demonstrates compound toxicity on calcium activity, synapses, viability and cell proliferation	0
Development of a high-throughput system for advanced functional cell analysis to predict safety	0
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment	0
Anticoagulant activity of Eucalyptus essential oils: An in vitro approach and a bioinformatics-based pharmacokinetic-pharmacodynamic analysis	0
Intravenous self-administration – Valid experimental designs to evaluate the abuse potential of psychedelics, entactogens and drugs with novel mechanisms	0
Surgical instrumentation for concomitant systemic blood pressure and blood sampling in healthy rabbits	0
Cardiovascular assessment of lipid nanoparticle-encapsulating mRNA therapeutics in rats using telemetry and Star-Oddi logger devices	0
Editorial Board	0
Chronic assessment of hERG trafficking on repolarisation and cytotoxicity in iPSC cardiomyocytes	0
High-throughput assessment of cardiac safety via calcium and voltage imaging of 3D engineered heart tissues and 2D cell cultures using a novel instrumentation platform	0
Revisiting the high-fat diet/low streptozotocin prediabetic rat model: A bioanalytical adjustment	0
Analysis of baroreflex and heart rate variability – Tools in cardiovascular pre-clinical safety studies	0
Validation of in vivo QT ICH E14/S7B Q&A guidance in minipig	0
Assay development and validation to measure contraction force from co-culture of human iPSC-derived cardiomyocytes and cardiac fibroblasts on the FLEXcyte 96 system	0
ICH S7B hERG and cardiac repolarization assays do not address mechanisms of QT prolongation for peptide and protein products	0
Optimization of bioanalysis of dried blood samples	0
Fast urine metabolomics for the assessment of Zopiclone effects on insomnia	0
Telemetry in toxicology studies – A comparison of data across species, technologies and time	0
Simultaneous quantification of thalidomide, lenalidomide and pomadomide in plasma by LC-MS/MS	0
Artificial intelligence-based phenotypic characterization of gender-specific, patient – iPSC derived cardiomyocyte cell models	0
Safety Pharmacology: Achieving a quarter century milestone as a scientific discipline	0
Changes in the nerve conduction (NC) of juvenile rodents due to maturation with implications for preclinical evaluation of toxic neuropathies	0
Evaluation of the sensitivity/specificity of statistical analysis strategies for detecting moxifloxacin-induced QTc prolongation	0
A plug-and-play μFluidic adaptor: Transforming standard well plates into microphysiological systems to assess (pharmaco)kinetics in vitro	0
From cellular waste to biomarkers; insights into past, present, and future methods to detect immune cell-derived extracellular vesicles using flow cytometry	0
Video-based detection of pentylenetetrazol induced severe convulsions in cynomolgus monkeys	0
Comparison of electrocardiogram and blood pressure recording methods in non-rodent toxicology studies: A retrospective analysis	0