OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological and Toxicological Methods is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Visualizing QT prolongation in the anesthetized guinea pig	27
Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk	27
Editorial Board	25
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	23
Chronic bladder catheterization for precise urine collection in awake mice	19
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	18
The underlying molecular mechanisms of drug-induced seizures	16
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	14
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	13
Drug-target interaction prediction using reliable negative samples and effective feature selection methods	13
A stable cell line inducibly expressing hERG1a/1b heteromeric channels	11
Organelle profiling of compound-induced effects in human iPSC-derived cardiomyocytes in combination with electrophysiology assays for in vitro prediction of cardiac safety	10
Contractility assessment using aligned human iPSC-derived cardiomyocytes	10
Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform	10
The impact of collaborative science on cardiovascular safety evaluation – A 10-year update of the HESI cardiac safety committee	10
Assessment of abuse liability and respiratory effects of mitragynine and 7-hydroxymitragynine in rats	10
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	8
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	8
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice	8
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	8
Automated cardiac tissue assay system with perfusion for monitoring contractility	8
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	7
hiPSC-derived neurons and multi-electrode array (MEA): Powerful tools within safety pharmacology for identifying the CNS modifying effects of compounds targeting ligand- and voltage-gated ion channels	7
Development of electrophysiological toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	7
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	7

One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	7
Ciprofloxacin does not accelerate aortic stiffness or aortic dilation in healthy, hypertensive and diseased mouse models	7
Effect of telemetry study design on minimum detectable difference values for QTc interval	6
In vitro neurotoxicity testing using functional human iPSC-derived neurons	6
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™	6
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease	6
Model versus scientist: Cardiac toxicity predictions—safety pharmacologists correlate with the CiPA model	6
Monitoring cardiomyocyte function with hybrid EFP-impedance technology for drug safety evaluation	6
Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies	6
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models	6
An investigation into the relationship between acetazolamide systemic exposure, blood gas changes and ventilatory parameters in the sprague Dawley® rat	6
Comparison between collagen and fibrin matrices in 3D cardiac tissue engineering	6
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits	6
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration	6
Editorial Board	5
Assessment of cardiac reserve and chronotropic effects using dobutamine stress echocardiography in healthy male rats	5
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain	5
Lung physiology and controlled exposure study design	5
Variations in neuron: Glia ratio may alter sensitivity to detect seizurogenic potential of drugs	5
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone	5
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology	5
Detecting immunotoxicity in vitro—clinically relevant studies in the COVID-19 era	5
Quantitative protein profiling of phenobarbital-induced drug metabolizing enzymes in rat liver by liquid chromatography mass spectrometry using formalin-fixed paraffin-embedded samples	5
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	4
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys	4
Minimal requirements for stem-cells derived cardiomyocytes and MEA usage in view of field potential analysis by reverse modeling - A theoretical study on the impact of 3 variability factors	4
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis	4
Serum starvation magnifies the delayed suppression of IK by probucol	4
Recording of transcellular voltage deflections from cardiomyocytes on MEA devices using laser poration	4
Non-invasive monitoring of cardiac output: Validation in anesthetized laboratory rats by pharmacological beta-adrenergic pathway modulation	4
Taking a deep breath: Evidence-based approaches to respiratory safety assessment	4
Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?	4
An in silico approach during safety pharmacology studies	4
Evaluation of the head twitch response in male C57BL/6J mice as a measure of 5-HT receptor activation	4
Gene therapy: A different challenge for toxicologists?	4
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	4
Editorial Board	4
Establishment of high-throughput toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	4
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment	3
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	3
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	3
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog	3
Cardiotoxicity with immune checkpoint inhibitors	3
A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods	3
Improving on-tissue detection of doxorubicin by using matrix assisted laser desorption ionization mass spectrometry imaging	3
Use of automated patch clamp in cardiac safety assessment: past, present and future perspectives	3
Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity	3
Establishment of functional observational battery test in large animals (dogs and non-human primates)	3
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	3
Cardiac 3D electromechanical tissue simulations for cardiac safety analysis	3

Mouse models for actinic keratoses	3
QT Ratio: A simple solution to individual QT correction	3
Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans	3
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	3
Editorial Board	3
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay	3
Voltage imaging of single contracting human iPSC-CMs using ratiometric voltage-sensitive dyes	3
Evoked responses to electrical stimulation in acute brain slice using a high-density and large-scale CMOS-MEA system	3
Using automated patch clamp for high throughput pharmacological characterization of cardiac action potentials	3
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization	2
Discovery and development of digital biomarkers to inform home-cage neuro-behavioral assessments in the rodent	2
A translational study between human induced pluripotent stem cell-derived cardiomyocytes (Hipsc-Cm) and an in vivo model to predict proarrhythmogenic properties	2
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients	2
Virtual clinical QT exposure-response studies – A translational computational approach	2
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	2
Development of a novel milli-fluidic liver tissue chip for mechanistic drug-induced liver injury (DILI) studies	2
Multi-site validation of in vivo QT ICH E14/S7B Q&A guidance in canines and non-human primates	2
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	2
State-of-the-art in secondary pharmacology and its impact on the safety of new medicines	2
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee	2
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	2
Combining a systems immunology approach with in vitro data to evaluate drug-induced changes in the immune response after Influenza A Virus infection – A blueprint for the preclinical assessment of inf	2
Long-term monitoring of cardiac action potentials for the assessment of chronic cardiotoxicity	2
Editorial Board	2
Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study	2
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak	2
Lipopolysaccharide-induced abdominal nociception model in adult zebrafish (Danio rerio)	2
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients	2
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	2
Dog and minipig telemetry assay sensitivity to detect QTc prolongation: Moxifloxacin effects by timepoint and concentration-QTc relationship analysis	2
Identification of pharmacological targets involved in drug-induced thermoregulation impairment	2
Recommendations on the measurement of electrocardiogram and hemodynamic parameters in restrained non-rodent species in regulatory safety assessment studies	1
Preclinical nerve conduction: Nerve battery options for primate studies	1
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	1
Snapshot versus continuous analysis of respiratory parameters collected by whole body plethysmography following oral administration of caffeine and baclofen in conscious unrestrained rats	1
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay	1
Test facility management: Responsibilities and paradigms of a new era	1
Editorial Board	1
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	1
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats	1
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys	1
A comparison of multiple left ventricular pressure endpoints as a screening tool in rats	1
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	1
Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies	1
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis	1
The role of the central amygdala in threat response in a semi-natural environment	1
Establishing an in vitro assay for predicting neurotoxicity risks using functional human iPSC-derived neurons	1
The electrophysiological responses to antibacterial drugs in human iPSC-derived neurons demonstrate the classification of antibacterial drug encephalopathy clinically	1
Chemometrics-assisted spectrophotometric method for the simultaneous determination of phenylephrine hydrochloride, chlorpheniramine maleate and paracetamol	1
A method for assessing and monitoring consistency of nonclinical ECG analysis	1
Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel	1
Angiotensin II as a linking factor in cardiovascular disease enhanced cancer growth	1
A comparative study of kidney lithogenic agents in Wistar rats by invasive and noninvasive methods	1
Multiplexed structure-function assay for high throughput drug safety testing on human induced pluripotent stem cell-derived cardiomyocytes and neurons	1
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	1
Using cultured human myocardial tissue slices to test cardiotoxic effects	1
Editorial Board	1
Editorial Board	1
CNS safety assessment in freely moving socially housed rodents	1
High-content cell imaging for chemical toxicity screening in the model organism Caenorhabditis elegans	1
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	1
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies with alternative study designs in non-rodent species	1
Intravenous self-administration in the rat: Advantage of transcutaneous buttons for improving the animal welfare	1
Editorial Board	1
Editorial Board	1
Chicken embryo as animal model to study drug distribution to the developing brain	1
Long-term inhibition of PI3K/Akt signaling by amiodarone augments late sodium current in CHO cells and hiPSC-CMs	1
Cardiac injury miRNA profile in breast cancer patients treated with left-sided radiotherapy	1
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	1
Drug combination assays using Caenorhabditis elegans as a model system	1
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	1
A new approach for purification of the catalytic site of the angiotensin-conversion enzyme, N-domain, mediated by the ELP-Intein system	1
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction	1
An evaluation of detection sensitivity and pharmacokinetic profile for conscious telemetered cynomolgus monkeys	1
Development of a pharmaceutical database to support the nonclinical evaluation of drug-induced cardiac toxicity	1
Electrophysiological analysis of seroquel’s activity in sodium ion channels, CiPA ion channels and hiPSC-neuronal cells	1
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods	1
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	1
In silico predictions of drug-induced changes on cardiac contractility in human ventricular cardiomyocytes	1
In vitro systems for the assessment of chronic cardiotoxic effects: News from the HESI stem cell working group	1