OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological and Toxicological Methods is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk	28
Visualizing QT prolongation in the anesthetized guinea pig	27
Editorial Board	24
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	23
Chronic bladder catheterization for precise urine collection in awake mice	20
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	17
The underlying molecular mechanisms of drug-induced seizures	13
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	13
Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform	12
The impact of collaborative science on cardiovascular safety evaluation – A 10-year update of the HESI cardiac safety committee	12
Contractility assessment using aligned human iPSC-derived cardiomyocytes	12
Organelle profiling of compound-induced effects in human iPSC-derived cardiomyocytes in combination with electrophysiology assays for in vitro prediction of cardiac safety	12
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	11
Automated cardiac tissue assay system with perfusion for monitoring contractility	10
Drug-target interaction prediction using reliable negative samples and effective feature selection methods	10
Assessment of abuse liability and respiratory effects of mitragynine and 7-hydroxymitragynine in rats	10
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	9
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	9
hiPSC-derived neurons and multi-electrode array (MEA): Powerful tools within safety pharmacology for identifying the CNS modifying effects of compounds targeting ligand- and voltage-gated ion channels	9
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	8
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	8
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	8
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration	8
Ciprofloxacin does not accelerate aortic stiffness or aortic dilation in healthy, hypertensive and diseased mouse models	8
An investigation into the relationship between acetazolamide systemic exposure, blood gas changes and ventilatory parameters in the sprague Dawley® rat	7

Comparison between collagen and fibrin matrices in 3D cardiac tissue engineering	7
Development of electrophysiological toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	7
Effect of telemetry study design on minimum detectable difference values for QTc interval	7
Monitoring cardiomyocyte function with hybrid EFP-impedance technology for drug safety evaluation	7
Model versus scientist: Cardiac toxicity predictions—safety pharmacologists correlate with the CiPA model	7
Variations in neuron: Glia ratio may alter sensitivity to detect seizurogenic potential of drugs	6
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone	6
Editorial Board	6
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease	6
Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies	6
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology	6
Detecting immunotoxicity in vitro—clinically relevant studies in the COVID-19 era	6
Quantitative protein profiling of phenobarbital-induced drug metabolizing enzymes in rat liver by liquid chromatography mass spectrometry using formalin-fixed paraffin-embedded samples	6
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits	6
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models	6
In vitro neurotoxicity testing using functional human iPSC-derived neurons	6
Assessment of cardiac reserve and chronotropic effects using dobutamine stress echocardiography in healthy male rats	6
Non-invasive monitoring of cardiac output: Validation in anesthetized laboratory rats by pharmacological beta-adrenergic pathway modulation	6
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™	6
Lung physiology and controlled exposure study design	6
Gene therapy: A different challenge for toxicologists?	5
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain	5
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys	5
Minimal requirements for stem-cells derived cardiomyocytes and MEA usage in view of field potential analysis by reverse modeling - A theoretical study on the impact of 3 variability factors	5
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	5
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis	5
Taking a deep breath: Evidence-based approaches to respiratory safety assessment	5
Preclinical cardiotoxicity assessment: Can stem cell-derived cardiomyocytes contribute to the 3Rs?	5
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	5
An in silico approach during safety pharmacology studies	4
Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans	4
Recording of transcellular voltage deflections from cardiomyocytes on MEA devices using laser poration	4
Establishment of functional observational battery test in large animals (dogs and non-human primates)	4
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	4
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	4
Editorial Board	4
QT Ratio: A simple solution to individual QT correction	4
Improving on-tissue detection of doxorubicin by using matrix assisted laser desorption ionization mass spectrometry imaging	4
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog	4
Serum starvation magnifies the delayed suppression of IK by probucol	4
Establishment of high-throughput toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	4
Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment	4
Using automated patch clamp for high throughput pharmacological characterization of cardiac action potentials	4
Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity	4
Evaluation of the head twitch response in male C57BL/6J mice as a measure of 5-HT receptor activation	4
Cardiac 3D electromechanical tissue simulations for cardiac safety analysis	3
Voltage imaging of single contracting human iPSC-CMs using ratiometric voltage-sensitive dyes	3
Evoked responses to electrical stimulation in acute brain slice using a high-density and large-scale CMOS-MEA system	3
Combining a systems immunology approach with in vitro data to evaluate drug-induced changes in the immune response after Influenza A Virus infection – A blueprint for the preclinical assessment of inf	3
A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods	3

Multi-site validation of in vivo QT ICH E14/S7B Q&A guidance in canines and non-human primates	3
Cardiotoxicity with immune checkpoint inhibitors	3
Editorial Board	3
Development of a novel milli-fluidic liver tissue chip for mechanistic drug-induced liver injury (DILI) studies	3
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients	3
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay	3
Dog and minipig telemetry assay sensitivity to detect QTc prolongation: Moxifloxacin effects by timepoint and concentration-QTc relationship analysis	3
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	3
Long-term monitoring of cardiac action potentials for the assessment of chronic cardiotoxicity	3
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients	3
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee	3
Virtual clinical QT exposure-response studies – A translational computational approach	3
A translational study between human induced pluripotent stem cell-derived cardiomyocytes (Hipsc-Cm) and an in vivo model to predict proarrhythmogenic properties	2
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	2
Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak	2
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis	2
In silico predictions of drug-induced changes on cardiac contractility in human ventricular cardiomyocytes	2
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	2
Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies	2
Development of a pharmaceutical database to support the nonclinical evaluation of drug-induced cardiac toxicity	2
Discovery and development of digital biomarkers to inform home-cage neuro-behavioral assessments in the rodent	2
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	2
Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study	2
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys	2
Editorial Board	2
The role of the central amygdala in threat response in a semi-natural environment	2
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	2
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods	2
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	2
State-of-the-art in secondary pharmacology and its impact on the safety of new medicines	2
Identification of pharmacological targets involved in drug-induced thermoregulation impairment	2
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	2
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization	2
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	2
Editorial Board	2
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	2
An evaluation of detection sensitivity and pharmacokinetic profile for conscious telemetered cynomolgus monkeys	1
Snapshot versus continuous analysis of respiratory parameters collected by whole body plethysmography following oral administration of caffeine and baclofen in conscious unrestrained rats	1
Chemometrics-assisted spectrophotometric method for the simultaneous determination of phenylephrine hydrochloride, chlorpheniramine maleate and paracetamol	1
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay	1
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction	1
Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel	1
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	1
The use of hypercapnic conditions to assess opioid-induced respiratory depression in rats	1
A new approach for purification of the catalytic site of the angiotensin-conversion enzyme, N-domain, mediated by the ELP-Intein system	1
Adding artificial arrhythmias during training boosts the performance of neuronal networks for arrhythmia detection	1
Recommendations on the measurement of electrocardiogram and hemodynamic parameters in restrained non-rodent species in regulatory safety assessment studies	1
Intravenous self-administration in the rat: Advantage of transcutaneous buttons for improving the animal welfare	1
Drug combination assays using Caenorhabditis elegans as a model system	1
A comparison of multiple left ventricular pressure endpoints as a screening tool in rats	1
A comparative study of kidney lithogenic agents in Wistar rats by invasive and noninvasive methods	1
Using cultured human myocardial tissue slices to test cardiotoxic effects	1
Angiotensin II as a linking factor in cardiovascular disease enhanced cancer growth	1
High-content cell imaging for chemical toxicity screening in the model organism Caenorhabditis elegans	1
Electrophysiological analysis of seroquel’s activity in sodium ion channels, CiPA ion channels and hiPSC-neuronal cells	1
Test facility management: Responsibilities and paradigms of a new era	1
Chicken embryo as animal model to study drug distribution to the developing brain	1
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	1
Astrocyte responses to seizurogenic compounds using MEA	1
Non-uniformity in in vitro drug-induced cytotoxicity as evidenced by differences in IC50 values – implications and way forward	1
Fun with pharmacology: Evaluating stresses on the system using the core battery	1
The electrophysiological responses to antibacterial drugs in human iPSC-derived neurons demonstrate the classification of antibacterial drug encephalopathy clinically	1
Editorial Board	1
Action potential recordings from air-shipped adult human primary cardiomyocytes	1
Editorial Board	1
Long-term inhibition of PI3K/Akt signaling by amiodarone augments late sodium current in CHO cells and hiPSC-CMs	1
CNS safety assessment in freely moving socially housed rodents	1
Cardiac injury miRNA profile in breast cancer patients treated with left-sided radiotherapy	1
Multiplexed structure-function assay for high throughput drug safety testing on human induced pluripotent stem cell-derived cardiomyocytes and neurons	1
Preclinical nerve conduction: Nerve battery options for primate studies	1
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	1
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	1
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	1
Editorial Board	1
Inter-rater agreement between WHO- Uppsala Monitoring Centre system and Naranjo algorithm for causality assessment of adverse drug reactions	1
In vitro systems for the assessment of chronic cardiotoxic effects: News from the HESI stem cell working group	1
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies with alternative study designs in non-rodent species	1
Editorial Board	1
Establishing an in vitro assay for predicting neurotoxicity risks using functional human iPSC-derived neurons	1
A method for assessing and monitoring consistency of nonclinical ECG analysis	1