OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Pharmacological and Toxicological Methods is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
First-order compartment model solutions – Exponential sums and beyond	26
Editorial Board	24
Validation of a simple spectrophotometric method for the rapid determination of salicylates in plasma	23
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	16
A comparison of activity data generated from cardiovascular telemetry studies - With quantitative open field locomotor studies in Wistar Han rats	16
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	16
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	14
Editorial Board	14
A novel device for serial venous blood sampling in a canine model	13
Nonclinical cardiovascular safety assessment of thioridazine: Impact of autonomic tone, body temperature, and choice of species	13
Flavonoids from Chromolaena leivensis and Caesalpinia spinosa as potential protectors against doxorubicin-induced cardiomyopathy	12
Human iPS cell-derived cardiomyocytes aligning on flexible gelatin fiber network show contraction and pharmacological responses relevant to human heart	11
An integrative computational platform for the multiparametric analysis of cardiomyocyte signals	10
Three in silico human iPSC cardiomyocyte models to recapitulate in vitro drug trials	10
Improved screening of the cardiovascular safety of COVID-19 anti-viral compounds	10
Evaluation of four in silico biomarkers for drug-induced proarrhythmic risk: COVID-19 off-label therapies case study	10
Effect of hydroxychloroquine on proarrhythmia risk assessment using human iPSC-derived cardiomyocytes	9
MEA assessment to anti-epilepsy drugs in human iPSC-derived neural network	8
Chronic bladder catheterization for precise urine collection in awake mice	8
Modeling chemotherapy-induced peripheral neuropathy using a nerve-on-a-chip microphysiological system	8
Preclinical comprehensive in vitro proarrhythmic assays demonstrate that omecamtiv mecarbil has low proarrhythmic risk	8
The underlying molecular mechanisms of drug-induced seizures	8
Visualizing QT prolongation in the anesthetized guinea pig	7
Biological variations in hemodynamics and electrocardiogram rhythms among telemetered cynomolgus monkeys	7
Identification of pharmacological targets involved in drug-induced thermoregulation impairment	7

Differentiating multichannel block on the guinea pig ECG: Use of Tpeak-Tend and J-Tpeak	7
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	6
Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity	6
Characteristics of histamine H4 receptor agonist-induced allergic conjunctivitis model in Guinea pigs	6
A fast optical kinetic plate reader for assessing action potentials in human-induced pluripotent stem cell cardiomyocytes	6
Maximizing insights from nonclinical safety studies in the context of rising costs and changing regulations	6
Acute cell stress screen with supervised machine learning predicts cytotoxicity of excipients	6
Contractility assessment using aligned human iPSC-derived cardiomyocytes	6
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	6
Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models	6
Cytochrome P450 3A4 (CYP3A4) protein quantification using capillary western blot technology and total protein normalization	5
Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	5
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	5
Prediction of GABA receptor antagonist-induced convulsion in cynomolgus monkeys by combining machine learning and heart rate variability analysis	5
Assessment of corrected JT-peak (JTpc) and Tpeak-to-Tend (TpTec) as proarrhythmia biomarkers in non-human primates: Outcome from a HESI consortium	5
Comparative analysis of high-throughput RNA extraction kits in Naïve Non-Human Primate (NHP) tissues for downstream applications utilizing Xeno Internal Positive Control (IPC)	5
A highly efficient liquid chromatography–tandem mass spectrometry (LC–MS/MS) assay for etomidate and etomidate acid in urine, liver and kidney	5
Drug-target interaction prediction using reliable negative samples and effective feature selection methods	4
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	4
Efficient and modified 2-NBDG assay to measure glucose uptake in cultured myotubes	4
An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum	4
“Appraisal of state-of-the-art” The 2021 Distinguished Service Award of the Safety Pharmacology Society: Reflecting on the past to tackle challenges ahead	4
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	4
The efficient method to get better raw brain signal on rat anesthetics experiment	4
Assessment of sarcomere shortening and calcium transient in primary human and dog ventricular myocytes	4
Non-invasive method of obtaining milk from mice using carbetocin, a synthetic analogue of oxytocin	4
l-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	4
A stable cell line inducibly expressing hERG1a/1b heteromeric channels	4
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	4
Understanding lymphatic drug delivery through chylomicron blockade: A retrospective and prospective analysis	4
High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells	4
Novel in vivo and ex vivo hybrid in vivo imaging system (IVIS) imaging offers a convenient and precise way to measure the glomerular filtration rate in conscious mice	3
Comparison of SYBR green I and lactate dehydrogenase antimalarial in vitro assay in Plasmodium falciparum field isolates	3
Evaluation of three different 99mTc-based mock-venom agents for lymphoscintigraphy studies in preclinical models of peripheral snakebite envenomation	3
Contractility assessment of human iPSC-derived cardiomyocytes by using a motion vector system and measuring cell impedance	3
Mechanical stimulation in a 2D high-throughput contractility system induces functional changes in human induced pluripotent stem cell-derived cardiomyocytes	3
Effects of intracellular fluoride and temperature on hERG blocker potency in vitro	3
HS-GC-FID method for quantification of HFA-152a in cell culture media, and plasma from a range of species and regulatory compliant validations	3
In vitro cardiac safety evaluation for repurposed COVID-19 drugs by using human iPS cell-derived cardiomyocyte with gelatin fiber scaffold	3
Human engineered cardiac tissues grown in a plate-based platform for analysis of acute and chronic contractility response	3
Improved seizure liability detection by combining rat hippocampal brain slice electrophysiology with in vivo behavior observation following intracerebroventricular drug administration	3
Screening of anticonvulsant activity of Xylopia aethiopica dry fruit using zebrafish	3
Editorial Board	3
Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity	3
Editorial Board	3
A genetic algorithm-based approach for the prediction of metabolic drug-drug interactions involving CYP2C8 or CYP2B6	3
Late sustained sodium current in the adult human heart	3
Standardization and validation of novel ex-vivo method for mitochondrial bioenergetics using mitochondrial modulators	3
Blood microsampling in cynomolgus monkey and evaluation of plasma PK parameters in comparison to conventional sampling	3
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	3

Assessment of intracellular accumulation of cadmium and thallium	2
Editorial Board	2
Expanding the number of validated iPSC-derived cardiomyocytes for safety pharmacology studies	2
An integrative pharmacokinetic-cardiovascular physiology modelling approach based on in vivo dog studies including five reference compounds	2
Assessment of cardiac safety liabilities via 3D engineered heart tissue contractility using a novel high-throughput instrumentation platform	2
Characterization of ascending dose canine telemetry model supports its use in E14/S7B QT integrated risk assessments	2
Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	2
A rapid spectrophotometric method to identify inhibitors of human erythropoiesis	2
Overcoming obstacles in three-dimensional cell culture model establishment: Approaches for growing A549 non-small cell lung cancer spheroids using a clinostat system	2
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins	2
Innovative approaches to cardiovascular safety pharmacology assessment	2
Artificial neural networks in cardiac safety assessment: Classification of chemotherapeutic compound effects on hiPSC-derived cardiomyocyte contractility	2
Seizure-induced Torsades de pointes:In a canine drug-induced long-QT1 model	2
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	2
Revisiting the high-fat diet/low streptozotocin prediabetic rat model: A bioanalytical adjustment	2
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	2
L-citrulline: A preclinical safety biomarker for the small intestine in rats and dogs in repeat dose toxicity studies	2
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	2
A bioanalytical assay for estimation of thymoquinone in rats cerebrospinal fluid and brain tissues of nasally administrated thymoquinone loaded lipo-polymeric nanoshells and its pharmacokinetic profil	2
Automated cardiac tissue assay system with perfusion for monitoring contractility	2
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	2
Drug testing using a novel in silico human cardiac Purkinje cell model and comparison with experimental data	2
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	2
Corrigendum to “The in vivo QTc core assay: An evaluation of QTc variability, detection sensitivity and implications for the improvement of conscious dog and non-human primate telemetry studies” [Jour	2
Ultraviolet spectrophotometry as method to determine the concentration of β-myrcene released from chitosan in aqueous medium	2