Journal of Pharmacological and Toxicological Methods

Article	Citations
A retrospective analysis of the concordance between cardiovascular effects in telemetry studies, toxicity studies, and early clinical trials	29
Quantitative comparison of ECG limb lead configurations: Evaluating synonymity of interval measurements using alternative leads under appropriately controlled study conditions	29
Metabolomics using high-resolution magic angle spinning nuclear magnetic resonance: Neurotoxicological applications	26
Corrigendum to ‘PolyCheck: A hybrid model for predicting polypharmacy-induced adverse drug reactions in tuberculosis treatment using heterogenous drug-target-ADR networks’ [Journal of pharmacological	22
Off-target of a novel TYK2 inhibitor is associated with myocardial necrosis mediated by hemodynamic changes in rats	20
Reproducible safety pharmacology echocardiography studies in vehicle-treated canines and NHPs	18
Development of simultaneous determination of dopamine 2, histamine 1, and muscarinic acetylcholine receptor occupancies by antipsychotics using liquid chromatography with tandem mass spectrometry	15
Overview of the bioanalytical methods used for the determination of benzodiazepines in biological samples and their suitability for emergency toxicological analysis	15
Comparison of cell viability methods for human mesenchymal/stromal stem cells and human A549 lung carcinoma cells after freeze-thaw stress	14
Chronic bladder catheterization for precise urine collection in awake mice	14
Editorial Board	13
Predicting human cardiac QT alterations and pro-arrhythmic effects of compounds with a 3D beating heart-on-chip platform	11
A personal reflection on 23 years of the Journal of pharmacological and toxicological methods	11
Organelle profiling of compound-induced effects in human iPSC-derived cardiomyocytes in combination with electrophysiology assays for in vitro prediction of cardiac safety	11
Assessment of abuse liability and respiratory effects of mitragynine and 7-hydroxymitragynine in rats	11
Contractility assessment using aligned human iPSC-derived cardiomyocytes	10
The impact of collaborative science on cardiovascular safety evaluation – A 10-year update of the HESI cardiac safety committee	10
Retrospective review of the safety pharmacology assessment of emerging therapeutic modalities approved from 2010 to 2023	9
hiPSC-derived neurons and multi-electrode array (MEA): Powerful tools within safety pharmacology for identifying the CNS modifying effects of compounds targeting ligand- and voltage-gated ion channels	9
Drug-target interaction prediction using reliable negative samples and effective feature selection methods	9
The visual field-testing maze and vision maze: Feasible techniques to evaluate visual field loss in animals	9
Optimization of an method for assessing pulmonary permeability of inhaled drugs using alveolar epithelial cells	9
Ciprofloxacin does not accelerate aortic stiffness or aortic dilation in healthy, hypertensive and diseased mouse models	9
In silico modelling of stroke volume, cardiac output and systemic vascular resistance in cardiovascular safety pharmacology studies by telemetry	9
Enhanced detection sensitivity in nonclinical cardiovascular telemetry studies: Impact of a characterized facility	8

Less invasive, simultaneous, and continuous measurements of locomotor activity and body temperature using the nano tag® small accelerometer device in cynomolgus monkeys	8
Enhanced interpretation of secondary pharmacology data through automated visualization tools to support safety assessment	8
Investigation of in vitro I /hERG assays under physiological temperature conditions using the semi-automated patch-clamp system QPatch compact with temperature control system	8
In-situ polyherbal gel as biomedicine in the management of Alzheimer's disease: Understanding ameliorative potential in Trimethyltin induced neurodegeneration	8
Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation	8
Effect of telemetry study design on minimum detectable difference values for QTc interval	8
Effects of temperature, compound concentration verification, and internal fluoride on hERG	8
Comparisons of hERG data for 30 drugs generated by automated and manual patch clamp systems by the same laboratory	7
Analyzing atrial human iPSC-cardiomyocyte responses to GPCR and ion channel modulators: Introducing a chamber-specific cell model for preclinical testing	7
Development of electrophysiological toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	7
Evaluation of the J-Tpeak and Tpeak-to-tend intervals of the ECG as proarrhythmia biomarkers in telemetered dogs	7
An investigation into the relationship between acetazolamide systemic exposure, blood gas changes and ventilatory parameters in the sprague Dawley® rat	7
Comparison of quinine-induced QRS prolongation in canine and primate telemetry studies: Applying concentration-effect modeling to assess ventricular conduction delay risk	7
Monitoring cardiomyocyte function with hybrid EFP-impedance technology for drug safety evaluation	7
Development and validation of a sensitive LC-MS/MS assay for determination of upadacitinib in human plasma and its application in patients with inflammatory bowel disease	6
Optimized J to T peak and T peak to T end measurements in nonclinical species administered moxifloxacin and amiodarone	6
Diisopropylfluorophosphate (DFP) volatizes and cross-contaminates wells in a common 96-well plate format used in zebrafish larvae toxicology studies	6
Simulated traumatic brain injury in in-vitro mouse neuronal and brain endothelial cell culture models	6
One step derivatization and dispersive liquid-liquid microextraction of hydroxychloroquine sulfate for its sensitive and accurate determination using GC–MS	6
Predicting clinical outcomes from off-target receptor interactions using Secondary Intelligence™	6
Development and validation of an LC-MSMS method for the quantitation of pacritinib; application of kinetics in rabbits	6
In-house fabrication of bipolar electrode-cannula assembly for electrical stimulation and drug delivery at the same site in rat brain	5
Non-invasive monitoring of cardiac output: Validation in anesthetized laboratory rats by pharmacological beta-adrenergic pathway modulation	5
In silico modeling of hemodynamic and autonomic effects of a selective α2-adrenoceptor agonist in beagle dogs by telemetry	5
Minimal requirements for stem-cells derived cardiomyocytes and MEA usage in view of field potential analysis by reverse modeling - A theoretical study on the impact of 3 variability factors	5
Meeting abstracts, Eighteenth Annual Themed Issue on Methods in Safety Pharmacology	5
Gene therapy: A different challenge for toxicologists?	5
Are current rat studies sensitive to detect blood pressure changes per the new FDA draft clinical blood pressure guidance?	4
Reference intervals and method sensitivity for electrocardiology, hemodynamics, and body temperature parameters in healthy cynomolgus monkeys	4
Neural network emulation of the human ventricular cardiomyocyte action potential: A promising tool for more efficient computations in quantitative systems pharmacology studies	4
Regulatory safety pharmacology & toxicology assessment studies: Measurement of the ECG and hemodynamic parameters in non-rodent species	4
An in silico approach during safety pharmacology studies	4
Computational modelling for improved translation of cardiac inotropic and lusitropic drug effects from rats to humans	4
Evaluation of the head twitch response in male C57BL/6J mice as a measure of 5-HT receptor activation	4
Establishment of functional observational battery test in large animals (dogs and non-human primates)	4
Protein malnutrition in BALB/C mice: A model mimicking clinical scenario of marasmic-kwashiorkor malnutrition	4
Exploratory safety investigations in normal, freely moving Göttingen Minipigs using telemetry: Pharmacological validation	4
The translation of hERG block and APD90 in vitro to clinical QTc prolongation in man	4
Performance and feasibility of three different approaches for computer based semi-automated analysis of ventricular arrhythmias in telemetric long-term ECG in cynomolgus monkeys	4
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies in non-rodent species: Delivering high quality QTc data to support ICH E14/S7B Q&As	4
Improving on-tissue detection of doxorubicin by using matrix assisted laser desorption ionization mass spectrometry imaging	4
Recording of transcellular voltage deflections from cardiomyocytes on MEA devices using laser poration	4
Editorial Board	4
QT Ratio: A simple solution to individual QT correction	4
Taking a deep breath: Evidence-based approaches to respiratory safety assessment	4
Using automated patch clamp for high throughput pharmacological characterization of cardiac action potentials	4
Non-clinical cardiovascular safety testing: Current status, gaps and emerging trends	4
Serum starvation magnifies the delayed suppression of IK by probucol	4
Establishment of high-throughput toxicity assay system with iPSC-derived GABAergic neurons generated by a rapid differentiation method	4
Collaborative science in action: A 20 year perspective from the Health and Environmental Sciences Institute (HESI) Cardiac Safety Committee	3

Effects of species of origin and mode of induction of microsomes on carbamazepine-induced cell toxicity	3
Assessing the cardiotoxicity of 31 compounds using a multiplexed kinetic image cytometry (KIC)-based assay: Harnessing the predictive power of human iPSC-cardiomyocytes for early drug development	3
Cardiac 3D electromechanical tissue simulations for cardiac safety analysis	3
Multi-site validation of in vivo QT ICH E14/S7B Q&A guidance in canines and non-human primates	3
Study to compare effects of a positive inotrope administered concurrently with a beta-blocker in ventricular Tachy-Paced dogs in mild heart failure	3
In silico modeling of effects of pimobendan on cardiac output and systemic vascular resistance in beagle dogs by telemetry	3
A retrospective review of the effects of moxifloxacin in NHP at four different test sites	3
Development of a novel milli-fluidic liver tissue chip for mechanistic drug-induced liver injury (DILI) studies	3
Combining a systems immunology approach with in vitro data to evaluate drug-induced changes in the immune response after Influenza A Virus infection – A blueprint for the preclinical assessment of inf	3
Dog and minipig telemetry assay sensitivity to detect QTc prolongation: Moxifloxacin effects by timepoint and concentration-QTc relationship analysis	3
Enhancing cardiac safety evaluation: Assessing drug interactions with the late Nav1.5 current	3
Ultra-fast UPLC–MS/MS approach for estimating X-376 in human liver microsomes: Evaluation of metabolic stability via in silico software and in vitro analysis	3
Long-term monitoring of cardiac action potentials for the assessment of chronic cardiotoxicity	3
Current practices on the measurement of electrocardiogram and hemodynamic parameters in non–rodent species in regulatory safety assessment studies	2
Elucidating the challenges with categorizing drugs that block cardiac sodium channels − The impact of temperature on drug-cardiac sodium channel interactions	2
QTc least significant difference in stand-alone implanted telemetry safety pharmacology and jacketed external telemetry regulatory toxicology studies in dogs	2
Variability of manual patch clamp hERG data generated using standardized protocols and following ICH S7B Q&A 2.1 best practices	2
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document	2
Editorial Board	2
Virtual clinical QT exposure-response studies – A translational computational approach	2
State-of-the-art in secondary pharmacology and its impact on the safety of new medicines	2
Lipopolysaccharide-induced abdominal nociception behavioral model in adult zebrafish (Danio rerio)	2
ICH E14/S7B Q&A integrated risk assessment: Strategies for managing TQT waivers if S7B non-clinical studies don't meet best practice expectations	2
High-throughput evaluation of cardiac electrophysiology and predicted actions on cardiac ion channels using hiPSC-CM and MEA technology	2
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog	2
Novel method for determination of colistin sulfate in human plasma by high-performance liquid chromatography-tandem mass spectrometry and its clinical applications in critically ill patients	2
Editorial Board	2
Spectrum of effects detected in the rat functional observational battery following administration of non-CNS targeted and CNS targeted compounds	2
Validation of an LC–MS/MS method for quantitation of fostemsavir in plasma	2
Correlation electrical repolarization and membrane hERG abundance in iPSC cardiomyocytes induced by chronic drugs actions on channel trafficking	2
Therapeutic drug monitoring of busulfan and cyclophosphamide in hematologic malignancies: An LC-MS/MS development, validation and application	2
Comparison of validity of standard nonclinical group size selection versus standard clinical group sizes for nonhuman primate QTc prolongation evaluation	2
Species comparison of compounds with known blood pressure effects in a vascular smooth muscle cell collagen contraction assay	2
A general and rapid LC-MS/MS method for simultaneous determination of voriconazole, posaconazole, fluconazole, itraconazole and hydroxyitraconazole in IFI patients	2
In silico predictions of drug-induced changes on cardiac contractility in human ventricular cardiomyocytes	2
A state-of-the-art method for high-throughput, automated locomotor activity testing in neuropharmacology, safety, and toxicology studies	1
Best practice considerations for nonclinical in vivo cardiovascular telemetry studies with alternative study designs in non-rodent species	1
hERG block potencies for 5 positive control drugs obtained per ICH E14/S7B Q&As best practices: Impact of recording temperature and drug loss	1
Cardiac injury miRNA profile in breast cancer patients treated with left-sided radiotherapy	1
Combination of quadrupole isotope dilution mass spectrometry with simultaneous derivatization and spray assisted droplet formation-liquid phase microextraction for the determination of methamphetamine	1
Long-term inhibition of PI3K/Akt signaling by amiodarone augments late sodium current in CHO cells and hiPSC-CMs	1
Importance of beating rate control for the analysis of drug effects on contractility in human induced pluripotent stem cell-derived cardiomyocytes	1
Improved translation of Nav1.5 channel inhibition to in vivo QRS interval prolongation via the hIPSC cardiomyocyte model	1
Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties	1
An evaluation of detection sensitivity and pharmacokinetic profile for conscious telemetered cynomolgus monkeys	1
Thirty years of telemetry-based data acquisition for cardiovascular drug safety evaluation: Applications and optimization	1
Angiotensin II as a linking factor in cardiovascular disease enhanced cancer growth	1
PolyCheck: A hybrid model for predicting polypharmacy-induced adverse drug reactions in tuberculosis treatment using heterogenous drug-target-ADR networks	1
A method for assessing and monitoring consistency of nonclinical ECG analysis	1
Fun with pharmacology: Evaluating stresses on the system using the core battery	1
A comparative study of kidney lithogenic agents in Wistar rats by invasive and noninvasive methods	1
High-content cell imaging for chemical toxicity screening in the model organism Caenorhabditis elegans	1
Evaluation of laser optoporation-induced action-potential-like measurements on iPSC-cardiomyocytes and the assessment of drug-induced effects on APD and contractility	1
Using cultured human myocardial tissue slices to test cardiotoxic effects	1
Intravenous self-administration in the rat: Advantage of transcutaneous buttons for improving the animal welfare	1
Toxicology and safety pharmacology investigations on the nervous system: 2024 industry survey	1
Enhancing the functional maturity of hiPSC-derived cardiomyocytes to assess inotropic compounds	1
Pharmacological assessments of NaV1.5 and hERG channel blockers in AV-ablated isolated rabbit heart assay under varying heart rates and temperatures	1
Development of a pharmaceutical database to support the nonclinical evaluation of drug-induced cardiac toxicity	1
A new approach for purification of the catalytic site of the angiotensin-conversion enzyme, N-domain, mediated by the ELP-Intein system	1
Identification of gene expression change associated with isoflurane anesthesia and neurocognitive disorders using bioinformatics methods	1
The translation of QTc across species - Impact of subject number and exposure multiple tested on discriminatory sensitivity	1
Discovery and development of digital biomarkers to inform home-cage neuro-behavioral assessments in the rodent	1
Editorial Board	1
Electrocardiography and heart rate variability in Göttingen Minipigs: Impact of diurnal variation, lead placement, repeatability and streptozotocin-induced diabetes	1
Editorial Board	1
The role of the central amygdala in threat response in a semi-natural environment	1
Editorial Board	1
In vitro systems for the assessment of chronic cardiotoxic effects: News from the HESI stem cell working group	1
A tiered approach to population-based in vitro testing for cardiotoxicity: Balancing estimates of potency and variability	1
Preclinical nerve conduction: Nerve battery options for primate studies	1
Evaluating the proarrhythmic risk of delayed-action compounds in serum free cell culture conditions; serum-starvation accelerates/amplifies the effect of probucol on the KCNQ1 + KCNE1 channel	1
Categorizing TdP risk with qNet: Effects of protocol design on HERG models and TMS outcomes	1
hERG agonists pose challenges to web-based machine learning methods for prediction of drug-hERG channel interaction	1
Editorial Board	1
Rodent models of anxiety and compulsion: When multiple endpoints add value	1
Characterization of a human wearable ECG device for continuous in-cage data collection in non-rodents	1
Snapshot versus continuous analysis of respiratory parameters collected by whole body plethysmography following oral administration of caffeine and baclofen in conscious unrestrained rats	1
Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide)	1
Compound A, a novel dual mu and kappa opioid receptor agonist that exerts potent an analgesic effect comparable to oxycodone, showed no reinforcing effect in monkeys	1

Stress-free blood sampling in minipigs: A novel method for assessing 24-h cortisol profiles and drug effects on diurnal and ultradian rhythms	1
Non invasive jacketed telemetry in socially-housed rats for a combined assessment of respiratory system, electrocardiogram and activity using the DECRO system	1
Optimization of a method to detect levothyroxine and related compounds in serum and urine by liquid chromatography coupled to triple quadrupole mass spectrometry	1
Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay	1
A translational study between human induced pluripotent stem cell-derived cardiomyocytes (Hipsc-Cm) and an in vivo model to predict proarrhythmogenic properties	1
A retrospective review of the effects of moxifloxacin in dogs at four different test sites	1
Chemometrics-assisted spectrophotometric method for the simultaneous determination of phenylephrine hydrochloride, chlorpheniramine maleate and paracetamol	1
Editorial Board	1
Surgical instrumentation of cardiovascular telemetry device has minimal impact on the general toxicology data interpretation in Cynomolgus monkeys	1
Drug combination assays using Caenorhabditis elegans as a model system	1
Test facility management: Responsibilities and paradigms of a new era	1