Molecular Biology of the Cell

Article	Citations
SuperPlotsOfData—a web app for the transparent display and quantitative comparison of continuous data from different conditions	103
Nuclear body phase separation drives telomere clustering in ALT cancer cells	81
Predicting cell health phenotypes using image-based morphology profiling	76
Direct evidence that tumor cells soften when navigating confined spaces	71
Correlating nuclear morphology and external force with combined atomic force microscopy and light sheet imaging separates roles of chromatin and lamin A/C in nuclear mechanics	67
BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins	61
Occludin and tricellulin facilitate formation of anastomosing tight-junction strand network to improve barrier function	59
Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes	54
SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation	50
Open-source deep-learning software for bioimage segmentation	49
Collagen, stiffness, and adhesion: the evolutionary basis of vertebrate mechanobiology	48
Roles of leader and follower cells in collective cell migration	47
The burden of service for faculty of color to achieve diversity and inclusion: the minority tax	44
Lipid and protein dynamics that shape nuclear envelope identity	44
Cooperation of the IFT-A complex with the IFT-B complex is required for ciliary retrograde protein trafficking and GPCR import	43
New twists in actin–microtubule interactions	43
pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells	42
Revised subunit order of mammalian septin complexes explains their in vitro polymerization properties	42
XK is a partner for VPS13A: a molecular link between Chorea-Acanthocytosis and McLeod Syndrome	41
Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion	39
Reorganization of budding yeast cytoplasm upon energy depletion	39
Three-dimensional superresolution fluorescence microscopy maps the variable molecular architecture of the nuclear pore complex	36
Long-range mechanical coupling of cells in 3D fibrin gels	34
Microtubule dynamics at low temperature: evidence that tubulin recycling limits assembly	34
Initiation and disassembly of filopodia tip complexes containing VASP and lamellipodin	34

Arf1 directly recruits the Pik1-Frq1 PI4K complex to regulate the final stages of Golgi maturation	33
Cholesterol-lowering drugs reduce APP processing to Aβ by inducing APP dimerization	33
Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons	33
Masters of asymmetry – lessons and perspectives from 50 years of septins	32
DNAJB12 and Hsp70 triage arrested intermediates of N1303K-CFTR for endoplasmic reticulum-associated autophagy	32
Endoplasmic reticulum stress causes insulin resistance by inhibiting delivery of newly synthesized insulin receptors to the cell surface	31
Nonmuscle myosin-2 contractility-dependent actin turnover limits the length of epithelial microvilli	30
Epithelial tissue geometry directs emergence of bioelectric field and pattern of proliferation	30
Freedom of assembly: metabolic enzymes come together	30
Diversity through equity and inclusion: The responsibility belongs to all of us	29
Abundances of transcripts, proteins, and metabolites in the cell cycle of budding yeast reveal coordinate control of lipid metabolism	29
High-throughput gene screen reveals modulators of nuclear shape	29
AnnotatorJ: an ImageJ plugin to ease hand annotation of cellular compartments	27
Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions	27
Cell Painting predicts impact of lung cancer variants	26
Mitochondria regulate intestinal stem cell proliferation and epithelial homeostasis through FOXO	26
Regulation of meiotic progression by Sertoli-cell androgen signaling	26
Phosphorylation of multiple proteins involved in ciliogenesis by Tau Tubulin kinase 2	26
Violin SuperPlots: visualizing replicate heterogeneity in large data sets	26
Peroxisomes exhibit compromised structure and matrix protein content in SARS-CoV-2-infected cells	25
An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field	25
The LINC complex is required for endothelial cell adhesion and adaptation to shear stress and cyclic stretch	24
Hsf1 activation by proteotoxic stress requires concurrent protein synthesis	24
FOXM1 nuclear transcription factor translocates into mitochondria and inhibits oxidative phosphorylation	24
Centrosome–nuclear axis repositioning drives the assembly of a bipolar spindle scaffold to ensure mitotic fidelity	24
R-loops at centromeric chromatin contribute to defects in kinetochore integrity and chromosomal instability in budding yeast	24
Dynamic actin cross-linking governs the cytoplasm’s transition to fluid-like behavior	24
Quantifying topography-guided actin dynamics across scales using optical flow	23
Robust classification of cell cycle phase and biological feature extraction by image-based deep learning	23
Beyond Langmuir: surface-bound macromolecule condensates	22
SUMO paralogue–specific functions revealed through systematic analysis of human knockout cell lines and gene expression data	22
A role for keratins in supporting mitochondrial organization and function in skin keratinocytes	22
Mechanistic insights into actin-driven polarity site movement in yeast	22
Early and nonredundant functions of dynamin isoforms in clathrin-mediated endocytosis	22
XMAP215 and γ-tubulin additively promote microtubule nucleation in purified solutions	22
Fascin-induced actin protrusions are suppressed by dendritic networks in giant unilamellar vesicles	22
Src kinases relax adherens junctions between the neighbors of apoptotic cells to permit apical extrusion	22
Increased numbers of nucleoli in a genome-wide RNAi screen reveal proteins that link the cell cycle to RNA polymerase I transcription	21
Regulation of intestinal epithelial intercellular adhesion and barrier function by desmosomal cadherin desmocollin-2	21
PLK1 is required for chromosome compaction and microtubule organization in mouse oocytes	21
Integrin-linked kinase tunes cell–cell and cell-matrix adhesions to regulate the switch between apoptosis and EMT downstream of TGFβ1	21
WAVE1 and WAVE2 have distinct and overlapping roles in controlling actin assembly at the leading edge	21
The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis	21
An update on genetically encoded lipid biosensors	21
The receptor subunit Tom20 is dynamically associated with the TOM complex in mitochondria of human cells	21
Insulin-promoted mobilization of GLUT4 from a perinuclear storage site requires RAB10	21
Deep learning approach for quantification of organelles and misfolded polypeptide delivery within degradative compartments	21
Regulation of NRF1, a master transcription factor of proteasome genes: implications for cancer and neurodegeneration	21
SARS-CoV-2 down-regulates ACE2 through lysosomal degradation	21
Quantifying the roles of space and stochasticity in computer simulations for cell biology and cellular biochemistry	20

Cell-type-specific mechanical response and myosin dynamics during retinal lens development in Drosophila	20
Photobleaching step analysis for robust determination of protein complex stoichiometries	20
PP1 promotes cyclin B destruction and the metaphase–anaphase transition by dephosphorylating CDC20	20
Rpgrip1l controls ciliary gating by ensuring the proper amount of Cep290 at the vertebrate transition zone	20
Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation	20
Practical method for superresolution imaging of primary cilia and centrioles by expansion microscopy using an amplibody for fluorescence signal amplification	20
DynaMorph: self-supervised learning of morphodynamic states of live cells	20
Distinct proteostasis states drive pharmacologic chaperone susceptibility for cystic fibrosis transmembrane conductance regulator misfolding mutants	20
Catalysts for change: the cellular neurobiology of psychedelics	20
Proteomic analysis of desmosomes reveals novel components required for epidermal integrity	20
Multiple C2 domain–containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains	20
ESCRT-III and ER–PM contacts maintain lipid homeostasis	20
Substratum stiffness signals through integrin-linked kinase and β1-integrin to regulate midbody proteins and abscission during EMT	20
The ER protein Ema19 facilitates the degradation of nonimported mitochondrial precursor proteins	20
L-bodies are RNA–protein condensates driving RNA localization in Xenopus oocytes	19
Protein turnover dynamics suggest a diffusion-to-capture mechanism for peri-basal body recruitment and retention of intraflagellar transport proteins	19
Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane	19
Fibroblast to myofibroblast transition is enhanced by increased cell density	19
Ubiquitin–proteasome-mediated cyclin C degradation promotes cell survival following nitrogen starvation	19
Kinetochore proteins suppress neuronal microtubule dynamics and promote dendrite regeneration	19
Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division	19
Novel cytokinetic ring components drive negative feedback in cortical contractility	19
The TIM22 complex mediates the import of sideroflexins and is required for efficient mitochondrial one-carbon metabolism	19
Osmosensing by WNK Kinases	19
Importin binding mediates the intramolecular regulation of anillin during cytokinesis	18
Roles for L o microdomains and ESCRT in ER stress-induced lipid droplet microautophagy in budding yeast	18
Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch	18
Roles for ELMOD2 and Rootletin in ciliogenesis	18
DNA content contributes to nuclear size control inXenopus laevis	18
Structurally distinct endocytic pathways for B cell receptors in B lymphocytes	17
Microtubule-dependent pushing forces contribute to long-distance aster movement and centration inXenopus laevisegg extracts	17
The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery	17
Tumor microtubes connect pancreatic cancer cells in an Arp2/3 complex-dependent manner	17
The N- or C-terminal cytoplasmic regions of P4-ATPases determine their cellular localization	17
Matrix stiffness-sensitive long noncoding RNA NEAT1 seeded paraspeckles in cancer cells	17
A septin-Hof1 scaffold at the yeast bud neck binds and organizes actin cables	17
PLEKHA5, PLEKHA6, and PLEKHA7 bind to PDZD11 to target the Menkes ATPase ATP7A to the cell periphery and regulate copper homeostasis	17
Calcium spikes accompany cleavage furrow ingression and cell separation during fission yeast cytokinesis	17
Formation of the B9-domain protein complex MKS1–B9D2–B9D1 is essential as a diffusion barrier for ciliary membrane proteins	17
The HIF target ATG9A is essential for epithelial barrier function and tight junction biogenesis	17
β-catenin-mediated Wnt signal transduction proceeds through an endocytosis-independent mechanism	16
Scientific societies fostering inclusivity through speaker diversity in annual meeting programming: a call to action	16
Unconventional endocytosis and trafficking of transferrin receptor induced by iron	16
Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex	16
Regulation of apical constriction via microtubule- and Rab11-dependent apical transport during tissue invagination	16
Mapping the electrostatic profiles of cellular membranes	16
Asymmetric Rab activation of vacuolar HOPS to catalyze SNARE complex assembly	16
Mgr2 regulates mitochondrial preprotein import by associating with channel-forming Tim23 subunit	16
Differential requirements for the CENP-O complex reveal parallel PLK1 kinetochore recruitment pathways	16
Arf1 orchestrates Rab GTPase conversion at the trans-Golgi network	16
Structural insights into the cause of human RSPH4A primary ciliary dyskinesia	15
VPS13D interacts with VCP/p97 and negatively regulates ER- mitochondrial interactions	15
Cytoplasmic streaming drifts the polarity cue and enables posteriorization of theCaenorhabditis eleganszygote at the side opposite of sperm entry	15
Long-term mitochondrial stress induces early steps of Tau aggregation by increasing reactive oxygen species levels and affecting cellular proteostasis	15
A hybrid stochastic–deterministic mechanochemical model of cell polarization	15
Isotropic myosin-generated tissue tension is required for the dynamic orientation of the mitotic spindle	15
Elevating PI3P drives select downstream membrane trafficking pathways	15
β-actin contributes to open chromatin for activation of the adipogenic pioneer factor CEBPA during transcriptional reprograming	15
The prion-like domain of Fused in Sarcoma is phosphorylated by multiple kinases affecting liquid- and solid-phase transitions	15
PxdA interacts with the DipA phosphatase to regulate peroxisome hitchhiking on early endosomes	15
Whi5 is diluted and protein synthesis does not dramatically increase in pre-Start G1	15
The Hec1/Ndc80 tail domain is required for force generation at kinetochores, but is dispensable for kinetochore–microtubule attachment formation and Ska complex recruitment	14
A yeast FRET biosensor enlightens cAMP signaling	14
Selective destabilization of polypeptides synthesized from NMD-targeted transcripts	14
Superresolution light microscopy of the Drosophila histone locus body reveals a core–shell organization associated with expression of replication–dependent histone genes	14
APC regulation of ESRP1 and p120-catenin isoforms in colorectal cancer cells	14
Exploiting differential effects of actomyosin contractility to control cell sorting among breast cancer cells	14
ESCargo: a regulatable fluorescent secretory cargo for diverse model organisms	14
We need to address ableism in science	14
Measuring nucleus mechanics within a living multicellular organism: Physical decoupling and attenuated recovery rate are physiological protective mechanisms of the cell nucleus under high mechanical l	14
RTN4B interacting protein FAM134C promotes ER membrane curvature and has a functional role in autophagy	14
The ARF GAP ELMOD2 acts with different GTPases to regulate centrosomal microtubule nucleation and cytokinesis	14
Asymmetric chromosome segregation and cell division in DNA damage-induced bacterial filaments	14
Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis	13
The Borealin dimerization domain interacts with Sgo1 to drive Aurora B–mediated spindle assembly	13
Proteomic analysis of microtubule inner proteins (MIPs) in Rib72 null Tetrahymena cells reveals functional MIPs	13
RUSC2 and WDR47 oppositely regulate kinesin–1-dependent distribution of ATG9A to the cell periphery	13
p53 induces a survival transcriptional response after nucleolar stress	13
Diffusion of kinesin motors on cargo can enhance binding and run lengths during intracellular transport	13
PP2A-dependent TFEB activation is blocked by PIKfyve-induced mTORC1 activity	13

Spatial regulation of MCAK promotes cell polarization and focal adhesion turnover to drive robust cell migration	13
Single-molecule imaging of IQGAP1 regulating actin filament dynamics	13
Pannexin 1 mutation found in melanoma tumor reduces phosphorylation, glycosylation, and trafficking of the channel-forming protein	13
Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA	13
Hydrogen peroxide induces Arl1 degradation and impairs Golgi-mediated trafficking	13
Apical Constriction Reversal upon Mitotic Entry Underlies Different Morphogenetic Outcomes of Cell Division	13
Spatial heterogeneity of the cytosol revealed by machine learning-based 3D particle tracking	13
Cross talk-dependent cortical patterning of Rho GTPases during cell repair	13
Counting actin in contractile rings reveals novel contributions of cofilin and type II myosins to fission yeast cytokinesis	13
Quantification of microtubule stutters: dynamic instability behaviors that are strongly associated with catastrophe	13
Atg15 in Saccharomyces cerevisiae consists of two functionally distinct domains	13
EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8	12
Dynein self-organizes while translocating the centrosome in T-cells	12
Coupling to substrate adhesions drives the maturation of muscle stress fibers into myofibrils within cardiomyocytes	12
SCYL1 arginine methylation by PRMT1 is essential for neurite outgrowth via Golgi morphogenesis	12
Epistatic, synthetic, and balancing interactions among tubulin missense mutations affecting neurite growth inCaenorhabditis elegans	12
Nek8445, a protein kinase required for microtubule regulation and cytokinesis inGiardia lamblia	12
Nonmuscle myosin 2 regulates cortical stability during sprouting angiogenesis	12
Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control	12
Exploratory polarization facilitates mating partner selection in Saccharomyces cerevisiae	12
RAC1 induces nuclear alterations through the LINC complex to enhance melanoma invasiveness	12
Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton	12
Myosin II isoforms promote internalization of spatially distinct clathrin-independent endocytosis cargoes through modulation of cortical tension downstream of ROCK2	12
Flexible pivoting of dynamin pleckstrin homology domain catalyzes fission: insights into molecular degrees of freedom	12
Lamin A/C deficiency enables increased myosin-II bipolar filament ensembles that promote divergent actomyosin network anomalies through self-organization	11
Load adaptation by endocytic actin networks	11
Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole	11
PICH regulates the abundance and localization of SUMOylated proteins on mitotic chromosomes	11
Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport	11
Interplay of septin amphipathic helices in sensing membrane-curvature and filament bundling	11
Prostaglandins regulate invasive, collective border cell migration	11
How good are my data? Reference standards in superresolution microscopy	11
Ase1 domains dynamically slow anaphase spindle elongation and recruit Bim1 to the midzone	11
Geometry of the nuclear envelope determines its flexural stiffness	11
Polarized human cholangiocytes release distinct populations of apical and basolateral small extracellular vesicles	11
The two-hit theory hits 50	11
Modulating RhoA effectors induces transitions to oscillatory and more wavelike RhoA dynamics in Caenorhabditis elegans zygotes	11
Differential dephosphorylation of CTP:phosphocholine cytidylyltransferase upon translocation to nuclear membranes and lipid droplets	11
Cholesterol- and actin-centered view of the plasma membrane: updating the Singer–Nicolson fluid mosaic model to commemorate its 50th anniversary†	11
Phosphatidylinositol and phosphatidylinositol-3-phosphate activate HOPS to catalyze SNARE assembly, allowing small headgroup lipids to support the terminal steps of membrane fusion	11
NgCAM and VAMP2 reveal that direct delivery and dendritic degradation maintain axonal polarity	11
Mitotic spindle: lessons from theoretical modeling	11
Tight junction protein ZO-2 modulates the nuclear accumulation of transcription factor TEAD	10
Tau differentially regulates the transport of early endosomes and lysosomes	10
New signaling kid on the block: the role of the postmitotic midbody in polarity, stemness, and proliferation	10
Phosphorylation of the small heat shock protein HspB1 regulates cytoskeletal recruitment and cell motility	10
Telomere length set point regulation in human pluripotent stem cells critically depends on the shelterin protein TPP1	10
Uveal melanoma cells use ameboid and mesenchymal mechanisms of cell motility crossing the endothelium	10
One-step multiplex toolkit for efficient generation of conditional gene silencing human cell lines	10
Paxillin promotes breast tumor collective cell invasion through maintenance of adherens junction integrity	10
Cell cycle and developmental control of cortical excitability in Xenopus laevis	10
Integrin cross-talk modulates stiffness-independent motility of CD4+ T lymphocytes	10
Drosophilahistone locus body assembly and function involves multiple interactions	10
Microtubule dynamics influence the retrograde biased motility of kinesin-4 motor teams in neuronal dendrites	10
Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state	10
Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis	10
Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites	10
Fast and parallel nanoscale three-dimensional tracking of heterogeneous mammalian chromatin dynamics	10
Optical flow analysis reveals that Kinesin-mediated advection impacts the orientation of microtubules in theDrosophilaoocyte	10
Cdc7-mediated phosphorylation of Cse4 regulates high-fidelity chromosome segregation in budding yeast	10
Synergistic interactions between Cajal bodies and the miRNA processing machinery	10
Survey of cancer cell anatomy in nonadhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb–based migration	10
Reflections on race, ethnicity, and NIH research awards	10
From stem cell to immune effector: how adhesion, migration, and polarity shape T-cell and natural killer cell lymphocyte development in vitro and in vivo	10
More than just a ticket canceller: the mitochondrial processing peptidase tailors complex precursor proteins at internal cleavage sites	10
Conformational diversity of dynactin sidearm and domain organization of its subunit p150	10
Fibronectin fibril alignment is established upon initiation of extracellular matrix assembly	10
Nir1 constitutively localizes at ER–PM junctions and promotes Nir2 recruitment for PIP2 homeostasis	10
Mechanosensitive mTORC2 independently coordinates leading and trailing edge polarity programs during neutrophil migration	10
Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity	10
Scaling of biosynthesis and metabolism with cell size	10
BORC-ARL8-HOPS ensemble is required for lysosomal cholesterol egress through NPC2	10
The endoplasmic reticulum contributes to lysosomal tubulation/sorting driven by LRRK2	10
Roles for a lipid phosphatase in the activation of its opposing lipid kinase	10
Resveratrol and related stilbene derivatives induce stress granules with distinct clearance kinetics	10
ARHGAP4-SEPT2-SEPT9 complex enables both up- and down-modulation of integrin-mediated focal adhesions, cell migration, and invasion	10
F-actin organization and target constriction during primary macrophage phagocytosis is balanced by competing activity of myosin-I and myosin-II	9
Spatial proximity of proteins surrounding zyxin under force-bearing conditions	9
Intracellular connections between basal bodies promote the coordinated behavior of motile cilia	9
Quantitative live-cell PALM reveals nanoscopic Faa4 redistributions and dynamics on lipid droplets during metabolic transitions of yeast	9
Challenges and advice for MD/PhD applicants who are underrepresented in medicine	9
Docosahexanoic acid signals through the Nrf2–Nqo1 pathway to maintain redox balance and promote neurite outgrowth	9
Centrosomes are required for proper β-catenin processing and Wnt response	9
Maf1 regulates intracellular lipid homeostasis in response to DDR activation	9
Rap1 regulates apical contractility to allow embryonic morphogenesis without tissue disruption and acts in part via Canoe-independent mechanisms	9
An update to the CRM1 cargo/NES database NESdb	9
Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response	9
Evaluation of cell segmentation methods without reference segmentations	9
The short flagella 1 (SHF1) gene in Chlamydomonas encodes a Crescerin TOG-domain protein required for late stages of flagellar growth	9
Rnd2 differentially regulates oligodendrocyte myelination at different developmental periods	9
Developmental changes in ciliary composition during gametogenesis in Chlamydomonas	9
Nanoscale dynamics of actin filaments in the red blood cell membrane skeleton	9
Chromatin condensation regulates endothelial cell adaptation to shear stress	9
The biochemical composition of the actomyosin network sets the magnitude of cellular traction forces	9
Nucleoli and the nucleoli–centromere association are dynamic during normal development and in cancer	9