Molecular Biology of the Cell

Article	Citations
Preprint Highlight: Multiplexed bioluminescence microscopy via phasor analysis	63
Landmarks in the discovery of a role for actin in cell locomotion	55
You are the most valuable reagent in the lab: mental health before and during the pandemic	44
Analysis of the roles of phosphatidylinositol-4,5-bisphosphate and individual subunits in assembly, localization, and function of Saccharomyces cerevisiae target of rapamycin complex 2	41
Sequestration of the exocytic SNARE Psy1 into multiprotein nodes reinforces polarized morphogenesis in fission yeast	39
Preprint Highlight: Mitotic clustering of pulverized chromosomes from micronuclei	39
Load adaptation by endocytic actin networks	38
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic	36
After wounding, a G-protein coupled receptor promotes the restoration of tension in epithelial cells	35
Improved imaging and preservation of lysosome dynamics using silver nanoparticle-enhanced fluorescence	35
The outer kinetochore components KNL-1 and Ndc80 complex regulate axon and neuronal cell body positioning in the C. elegans nervous system	35
Image-based discrimination of the early stages of mesenchymal stem cell differentiation	34
STMND1 is a phylogenetically ancient stathmin which localizes to motile cilia and exhibits nuclear translocation that is inhibited when soluble tubulin concentration increases	33
p97/VCP Promotes the Recycling of Endocytic Cargo	30
Actin contraction controls nuclear blebbing and rupture independent of actin confinement	29
Mitotic spindle membranes	28
Sec18 binds the tethering/SM complex HOPS to engage the Qc-SNARE for membrane fusion	28
Dynamics of intracellular neonatal Fc receptor–ligand interactions in primary macrophages using biophysical fluorescence techniques	28
Interactions between TULP3 tubby domain and ARL13B amphipathic helix promote lipidated protein transport to cilia	26
Membrane lipids couple synaptotagmin to SNARE-mediated granule fusion in insulin-secreting cells	26
Preprint Highlight: Contractile ring mechanosensation and its anillin-dependent tuning during early embryogenesis	26
A troponin T variant linked with pediatric dilated cardiomyopathy reduces the coupling of thin filament activation to myosin and calcium binding	25
The story of science: successes, failures, luck, privilege, and bias	25
The initiation and early development of the tubulin-containing cytoskeleton in the human parasite Toxoplasma gondii	25
Preprint Highlight: Dynamic interplay of protrusive microtubule and contractile actomyosin forces drive tissue extension	25

Preprint Highlight: Self‐supervised deep learning encodes high-resolution features of protein subcellular localization	25
New signaling kid on the block: the role of the postmitotic midbody in polarity, stemness, and proliferation	25
Negative-sense RNA viruses: An underexplored platform for examining virus–host lipid interactions	25
A modified motor-clutch model reveals that neuronal growth cones respond faster to soft substrates	24
Preprint Highlight: Vimentin intermediate filaments organize organellar ER architecture in response to stress	24
Nir1 constitutively localizes at ER–PM junctions and promotes Nir2 recruitment for PIP2 homeostasis	23
Genetic inactivation of essential HSF1 reveals an isolated transcriptional stress response selectively induced by protein misfolding	23
Osh-dependent and -independent Regulation of PI4P Levels During Polarized Growth ofSaccharomyces cerevisiae	23
DAmFRET measures saturating concentrations and toxicities of protein phase transitions in vivo	22
Insights into the role of Nup62 and Nup93 in assembling cytoplasmic ring and central transport channel of the nuclear pore complex	22
A mathematical model of calcium signals around laser-induced epithelial wounds	22
Chaperone requirements for de novo folding of Saccharomyces cerevisiae septins	22
HSPA8 inhibitors augment cancer chemotherapeutic effectiveness via potentiating necroptosis	21
The nuclear isoforms of the Fragile X mental retardation RNA-binding protein associate with genomic DNA bridges	21
From pipette to palette: Bridging science and art at MBoC	20
Heterologous expression of Dictyostelium discoideum NE81 in mouse embryo fibroblasts reveals conserved mechanoprotective roles of lamins	20
Big1 is a newly identified autophagy regulator that is critical for a fully functional V-ATPase	20
Calcium-binding Cab45 regulates the polarized apical secretion of soluble proteins in epithelial cells	20
FHOD-1 and profilin protect sarcomeres against contraction-induced deformation> in C. elegans	19
Cell type- and transcription-independent spatial proximity between enhancers and promoters	19
Cell Painting predicts impact of lung cancer variants	19
Scaling of biosynthesis and metabolism with cell size	19
The SNARE-associated protein Sft2 functions in Imh1-mediated SNARE recycling transport upon ER stress	19
SUMO paralogue–specific functions revealed through systematic analysis of human knockout cell lines and gene expression data	19
Phosphorylation of the small heat shock protein HspB1 regulates cytoskeletal recruitment and cell motility	19
EHD2 regulates plasma membrane integrity and downstream insulin receptor signaling events	19
LYSET facilitates integration of both the N- and C-terminal transmembrane helices/cytoplasmic domains of GlcNAc-1-phosphotransferase	19
LGN loss randomizes spindle orientation and accelerates tumorigenesis in PTEN-deficient epidermis	18
Regulation of mitochondrial fission by GIPC-mediated Drp1 retrograde transport	18
Orchestrating nonmuscle myosin II filament assembly at the onset of cytokinesis	18
Postmitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells	18
Keratin 19 interacts with GSK3β to regulate its nuclear accumulation and degradation of cyclin D3	17
Serotonin 5-HT7 receptor slows down the Gs protein: a single molecule perspective	17
Atypical and distinct microtubule radial symmetries in the centriole and the axoneme of Lecudina tuzetae	17
Cytoplasmic preassembly of the flagellar outer dynein arm complex in Trypanosoma brucei	17
Regulation of membrane scission in yeast endocytosis	17
Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues	17
Cell segregation via differential collision modes between heterotypic cell populations	17
Regulation of misfolded protein aggregation and degradation by SUMOylation in budding yeast	17
MotiQ: an open-source toolbox to quantify the cell motility and morphology of microglia	17
Lgd regulates ESCRT-III complex accumulation at multivesicular endosomes to control intralumenal vesicle formation	17
Intracellular diffusion in the cytoplasm increases with cell size in fission yeast	16
Plectin linkages are mechanosensitive and required for the nuclear piston mechanism of three-dimensional cell migration	16
The Rab11-family interacting proteins reveal selective interaction of mammalian recycling endosomes with theToxoplasmaparasitophorous vacuole in a Rab11- and Arf6-dependent manner	16
Preexisting tissue mechanical hypertension at adherens junctions disrupts apoptotic extrusion in epithelia	16
The Kinesin-14 tail: Dual microtubule binding domains drive spindle morphogenesis through tight microtubule cross-linking and robust sliding	16
Spatiotemporal analysis of F-actin polymerization with micropillar arrays reveals synchronization between adhesion sites	16
Mechanisms underlying Myosin 10′s contribution to the maintenance of mitotic spindle bipolarity	15
Mff oligomerization is required for Drp1 activation and synergy with actin filaments during mitochondrial division	15
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division	15

The Midbody and Midbody Remnant: from cellular debris to signaling organelle with diagnostic and therapeutic potential	15
Practical guide to fluorescence lifetime imaging microscopy	15
Visualization of the three-dimensional structure of the human centromere in mitotic chromosomes by superresolution microscopy	15
p115RhoGEF activates RhoA to support tight junction maintenance and remodeling	14
Preprint Highlight: Real-time denoising of fluorescence time-lapse imaging enables high-sensitivity observations of biological dynamics beyond the shot-noise limit	14
Tools for live-cell imaging of cytoskeletal and nuclear behavior in the unconventional yeast, Aureobasidium pullulans	14
Multiple tethers of organelle contact sites are involved in α-synuclein toxicity in yeast	14
An updated SYSCILIA gold standard (SCGSv2) of known ciliary genes, revealing the vast progress that has been made in the cilia research field	14
Distinct peroxisome populations differentially respond to alcohol-associated hepatic injury	14
FOXO nuclear shuttling dynamics are stimulus-dependent and correspond with cell fate	14
Combining multiple fluorescence imaging techniques in biology: when one microscope is not enough	14
Breaking the rules of cell biology: Lessons from the liver's exceptional regenerative capacity	14
Interaction of the sorting nexin 25 homologue Snazarus with Rab11 balances endocytic and secretory transport and maintains the ultrafiltration diaphragm in nephrocytes	14
Remodeling of cytoskeleton, chromatin, and gene expression during mechanical rejuvenation of aged human dermal fibroblasts	14
The scaffold RhoGAP protein ARHGAP8/BPGAP1 synchronizes Rac and Rho signaling to facilitate cell migration	14
Modification of the neck-linker of KIF18A alters Microtubule subpopulation preference	14
Regulatory roles of fibronectin and integrin α5 in reorganization of the actin cytoskeleton and completion of adipogenesis	13
Endothelial tip/stalk cell selection requires BMP9-induced βIV-spectrin expression during sprouting angiogenesis	13
Activation of the ChvG-ChvI pathway promotes survival during cell wall stress in Agrobacterium tumefaciens	13
A role for the kinetochore protein, NUF2, in ribosome biogenesis	13
DLC-1 facilitates germ granule assembly in Caenorhabditis elegans embryo	13
A multiparametric activity profiling platform for neuron disease phenotyping and drug screening	13
Neuronal membrane proteasome-derived peptides modulate NMDAR-dependent neuronal signaling to promote changes in gene expression	13
Ninein domains required for its localization, association with partners dynein and ensconsin, and microtubule organization	13
Complex state transitions of the bacterial cell division protein FtsZ	13
Ovarian carcinoma immunoreactive antigen–like protein 2 (OCIAD2) is a novel complex III–specific assembly factor in mitochondria	13
Drosophila Fog/Cta and T48 pathways have overlapping and distinct contributions to mesoderm invagination	13
Outer-arm dynein light chain LC1 is required for normal motor assembly kinetics, ciliary stability, and motility	13
2022 ASCB Annual Meeting abstracts	13
Antiparallel microtubule bundling supports KIF15-driven mitotic spindle assembly	12
The transcriptional response to oxidative stress is independent of stress-granule formation	12
Temporal control of contact site formation reveals a relationship between mitochondrial division and Num1-mediated mitochondrial tethering	12
Preprint Highlight: Probing the rules of cell coordination in live tissues by interpretable machine learning based on graph neural networks	12
Imaging-based screen identifies novel natural compounds that perturb cell and chloroplast division in Chlamydomonas reinhardtii	12
Loss of intermicrovillar adhesion factor CDHR2 impairs basolateral junctional complexes in transporting epithelia	12
Multiple C2 domain–containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains	12
The role of neurofilament transport in the radial growth of myelinated axons	12
Preprint Highlight: FLAgellum Member 8 modulates extravascular trypanosome distribution in the mammalian host	12
Phospholipase D1 produces phosphatidic acid at sites of secretory vesicle docking and fusion	12
Coilin enhances phosphorylation and stability of DGCR8 and promotes miRNA biogenesis	12
Hsp40s play distinct roles during the initial stages of apolipoprotein B biogenesis	12
Preprint Highlight: Deciphering the tumor-specific immunopeptidome in vivo with genetically engineered mouse models	12
WAVE facilitates polarized E-cadherin transport	12
Myomegalin regulates Hedgehog pathway by controlling PDE4D at the centrosome	11
Independence of centromeric and pericentromeric chromatin stability on CCAN components	11
Transient PP2A SIP complex localization to mitotic SPBs for SIN inhibition is mediated solely by the Csc1 FHA domain	11
Dynein-dependent collection of membranes defines the architecture and position of microtubule asters in isolated, geometrically confined volumes of cell-free extracts	11
Catalysts for change: the cellular neurobiology of psychedelics	11
Aspergillus nidulans biofilm formation modifies cellular architecture and enables light-activated autophagy	11
The RhoGAP RRC-1 is required for the assembly or stability of integrin adhesion complexes and is a member of the PIX pathway in muscle	11
The RabGAPs EPI64A and EPI64B regulate the apical structure of epithelial cells†	11
Nucleolar structure connects with global nuclear organization	11
Megalin, cubilin, and Dab2 drive endocytic flux in kidney proximal tubule cells	11
The TOG5 domain of CKAP5 is required to interact with F-actin and promote microtubule advancement in neurons	11
Quantitative analysis of morphogenesis and growth dynamics in an obligate intracellular bacterium	11
Recruitment of the lipid kinase Mss4 to the meiotic spindle pole promotes prospore membrane formation in Saccharomyces cerevisiae	11
Nkd1 functions downstream of Axin2 to attenuate Wnt signaling	11
A WICB 50th Favorite: Endoplasmic reticulum–endosome contact increases as endosomes traffic and mature	11
Polymer dynamics of Alp7A reveals how two critical concentrations govern assembly of dynamically unstable actin-like proteins	11
The Drosophila spectraplakin Short stop regulates focal adhesion dynamics by cross-linking microtubules and actin	11
Preprint Highlight: The novel Rab5 effector FERRY links early endosomes with the translation machinery	11
The RhoGEF protein Plekhg5 regulates medioapical and junctional actomyosin dynamics of apical constriction during Xenopus gastrulation	11
Subunit exchange among endolysosomal tethering complexes is linked to contact site formation at the vacuole	10
RAD51 regulates eukaryotic chromatin motions in the absence of DNA damage	10
The roles of yeast formins and their regulators Bud6 and Bil2 in the pheromone response	10
How many authors does it take to publish a high profile or classic paper?	10
Plasma membrane protrusions mediate host cell–cell fusion induced by Burkholderia thailandensis	10
Scaling of nuclear numbers and their spatial arrangement in skeletal muscle cell size regulation	10
Growth cone macropinocytosis of neurotrophin receptor and neuritogenesis are regulated by neuron navigator 1	10
Preprint Highlight: PGC1α regulates the endothelial response to fluid shear stress via telomerase reverse transcriptase control of heme oxygenase‐1	10
CANVS: an easy-to-use application for the analysis and visualization of mass spectrometry–based protein–protein interaction/association data	10
Divergent polo boxes in KKT2 bind KKT1 to initiate the kinetochore assembly cascade in Trypanosoma brucei	10
Systematic analysis of microtubule plus-end networks defines EB-cargo complexes critical for mitosis in budding yeast	10
K-fiber bundles in the mitotic spindle are mechanically reinforced by Kif15	10
A novel tool for the unbiased characterization of epithelial monolayer development in culture	10
WHAMM functions in kidney reabsorption and polymerizes actin to promote autophagosomal membrane closure and cargo sequestration	10
A WICB 50th Favorite: Rapid lytic granule convergence to the MTOC in natural killer cells is dependent on dynein but not cytolytic commitment	10
2021 ASCB Annual Meeting abstracts	10
Preprint Highlight: LRRK2 Suppresses Lysosome Degradative Activity in Macrophages and Microglia via Transcription Factor E3 Inhibition	10
Identification of a Golgi-localized peptide reveals a minimal Golgi-targeting motif	10

L-bodies are RNA–protein condensates driving RNA localization in Xenopus oocytes	10
VAMP5 promotes Fcγ receptor-mediated phagocytosis and regulates phagosome maturation in macrophages	9
Polymer models reveal how chromatin modification can modulate force at the kinetochore	9
Results from the MBoC Preprint Highlight experiment	9
Measurements of neurite extension and nucleokinesis in an iPSC-derived model system following microtubule perturbation	9
A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents	9
Dishevelled controls bulk cadherin dynamics and the stability of individual cadherin clusters during convergent extension	9
Maximizing Access to Cell Biology for PEERS: Retracting the term minority in favor of a more inclusive lexicon	9
Quantitative live-cell PALM reveals nanoscopic Faa4 redistributions and dynamics on lipid droplets during metabolic transitions of yeast	9
Gβγ regulates mitotic Golgi fragmentation and G2/M cell cycle progression	9
The two-hit theory hits 50	9
Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch	9
A perinuclear α-helix with amphipathic features in Brl1 promotes NPC assembly	9
Mutation of the PEBP-like domain of the mitoribosomal MrpL35/mL38 protein results in production of nascent chains with impaired capacity to assemble into OXPHOS complexes	9
Cell adaptation to aneuploidy by the environmental stress response dampens induction of the cytosolic unfolded-protein response	9
Deafness mutation in the MYO3A motor domain impairs actin protrusion elongation mechanism	9
p52Shc regulates the sustainability of ERK activation in a RAF-independent manner	9
Survey of cancer cell anatomy in nonadhesive confinement reveals a role for filamin-A and fascin-1 in leader bleb–based migration	9
Preprint Highlight: Actomyosin cables position cell cohorts during Drosophila germband retraction by entraining their morphodynamic and mechanical properties	9
Preprint Highlight: Detyrosination enrichment on microtubule subsets is established by the interplay between a stochastically acting enzyme and microtubule stability	9
A dedicated cytoplasmic container collects extrachromosomal DNA away from the mammalian nucleus	9
Traveling-wave chemotaxis of neutrophil-like HL-60 cells	9
Nanotopography modulates cytoskeletal organization and dynamics during T cell activation	9
A year since George Floyd	9
Recruitment of PI4KIIIβ to the Golgi by ACBD3 is dependent on an upstream pathway of a SNARE complex and golgins	9
In vivo imaging reveals independent intraflagellar transport of the nexin–dynein regulatory complex subunits DRC2 and DRC4	9
CDK11 facilitates centromeric transcription to maintain centromeric cohesion during mitosis	9
The N-terminal tail of C. elegans CENP-A interacts with KNL-2 and is essential for centromeric chromatin assembly	9
Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes	9
Distinct proteostasis states drive pharmacologic chaperone susceptibility for cystic fibrosis transmembrane conductance regulator misfolding mutants	9
Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity	9
Loss of major nutrient sensing and signaling pathways suppresses starvation lethality in electron transport chain mutants	9
Preprint Highlight: Transcriptomic changes highly similar to Alzheimer's disease are observed in a subpopulation of individuals during normal brain aging	9
A methodology for specific disruption of microtubule polymerization into dendritic spines	8
Trafficking of K63-polyubiquitin–modified membrane proteins in a macroautophagy-independent pathway is linked to ATG9A	8
Ubiquitin-mediated recruitment of the ATG9A-ATG2 lipid transfer complex drives clearance of phosphorylated p62 aggregates	8
FAZ assembly in bloodstream formTrypanosoma bruceirequires kinesin KIN-E	8
Powering morphogenesis: multiscale challenges at the interface of cell adhesion and the cytoskeleton	8
Dysregulation of ceramide metabolism causes phytoceramide-dependent induction of the unfolded protein response	8
The unfolded protein response of the endoplasmic reticulum supports mitochondrial biogenesis by buffering nonimported proteins	8
M phase–specific generation of supernumerary centrioles in cancer cells	8
Myosin F controls actin organization and dynamics in Toxoplasma gondii	8
The ubiquitin ligases Cbl and Cbl-b regulate macrophage growth by controlling CSF-1R import into macropinosomes	8
Membrane stretching activates calcium permeability of a putative channel Pkd2 during fission yeast cytokinesis	8
Preprint Highlight: Disruption of lactate metabolism in the peripheral nervous system leads to motor selective deficits	8
Large-scale mapping of positional changes of hypoxia-responsive genes upon activation	8
Ultrastructure of COPII vesicle formation in yeast characterized by correlative light and electron microscopy	8
VAC14 oligomerization is essential for the function of the FAB1/PIKfyve-VAC14-FIG4 complex	8
Heh2/Man1 may be an evolutionarily conserved sensor of NPC assembly state	8
The [PSI+] prion modulates cytochrome c oxidase deficiency caused by deletion of COX12	8
Michael Patrick Sheetz, 1946-2025, a devotee of and major contributor to membrane and cytoskeletal biology	8
Differentiation-dependent changes in lamin B1 dynamics and lamin B receptor localization	8
A PACAP-activated network for secretion requires coordination of Ca2+ influx and Ca2+ mobilization	8
Diffusion within the synaptonemal complex can account for signal transduction along meiotic chromosomes	8
Preprint Highlight: The mechanosensitive ion channel Piezo mediates Rho activation and actin stress fibre formation in Drosophila nephrocytes	8
Enabled primarily controls filopodial morphology, not actin organization, in the TSM1 growth cone inDrosophila	8
FAP20 is required for flagellum assembly in Trypanosoma brucei	8
Cationic amphiphilic drugs induce accumulation of cytolytic lysoglycerophospholipids in the lysosomes of cancer cells and block their recycling into common membrane glycerophospholipids	8
Superresolution microscopy reveals actomyosin dynamics in medioapical arrays	8
Membrane fusion by Drosophila atlastin does not require GTP hydrolysis	8
A WICB 50th Favorite: Regulation of distinct septin rings in a single cell by Elm1p and Gin4p kinases	8
Evidence for novel mechanisms that control cell-cycle entry and cell size	8
VAMP2 and synaptotagmin mobility in chromaffin granule membranes: implications for regulated exocytosis	8
Homology-directed repair involves multiple strand invasion cycles in fission yeast	8
Inhibition of the chromatin remodeling factor NURF rescued sterility by a clinic variant of NuRD	8
AP-4 regulates neuronal lysosome composition, function, and transport via regulating export of critical lysosome receptor proteins at the trans-Golgi network	8
Preprint Highlight: Learning orientation-invariant representations enables accurate and robust morphologic profiling of cells and organelles	8
Lysosomal membrane proteins LAMP1 and LIMP2 are segregated in the Golgi apparatus independently of their clathrin adaptor binding motif	8
Inositol 1, 4, 5-trisphosphate receptor is required for spindle assembly in Xenopus oocytes	8
Remarkable chromosomes and karyotypes: A top 10 list	7
Microtubule dynamics influence the retrograde biased motility of kinesin-4 motor teams in neuronal dendrites	7
MRE11-independent effects of Mirin on mitochondrial DNA integrity and cellular immune responses	7
The C-terminus of α-Synuclein Regulates its Dynamic Cellular Internalization by Neurexin 1β	7
Computational simulations reveal that Abl activity controls cohesiveness of actin networks in growth cones	7
Preprint Highlight: Intertissue mechanical interactions shape the olfactory circuit in zebrafish	7
Interactions of ubiquitin and CHMP5 with the V domain of HD-PTP reveals role for regulation of Vps4 ATPase	7
The myosin chaperone UNC-45 has an important role in maintaining the structure and function of muscle sarcomeres during adult aging	7
On the inference of ERK signaling dynamics from protein biosensor measurements	7
Phospholipid flippases and Sfk1 are essential for the retention of ergosterol in the plasma membrane	7
A small-molecule inhibitor and degrader of the RNF5 ubiquitin ligase	7
Cytoplasmic keratins couple with and maintain nuclear envelope integrity in colonic epithelial cells	7
Time-resolved cryogenic electron tomography for the study of transient cellular processes	7
Preprint Highlight: Cell adhesions link subcellular actomyosin dynamics to tissue-scale-force production during vertebrate convergent extension	7
CD56/NCAM mediates cell migration of human NK cells by promoting integrin-mediated adhesion turnover	7
Mapping stress-responsive signaling pathways induced by mitochondrial proteostasis perturbations	7
Effects of phosphorylation on Drp1 activation by its receptors, actin, and cardiolipin	7
Ras-mediated activation of mTORC2 promotes breast epithelial cell migration and invasion	7
The microtubule- and PP1-binding activities of Drosophila melanogaster Spc105 control the kinetics of SAC satisfaction	7
Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality	7
Mechanical strategies supporting growth and size diversity in Filamentous Fungi	7
SPAK-dependent cotransporter activity mediates capillary adhesion and pressure during glioblastoma migration in confined spaces	7
Signaling of ghrelin at GHSR1b and OX1R receptor heterodimers	7
Significantly reduced, but balanced, rates of mitochondrial fission and fusion are sufficient to maintain the integrity of yeast mitochondrial DNA	7
Regulation of p65 nuclear localization and chromatin states by compressive force	7
Isoform-specific phosphorylation of axonemal dynein heavy chains	7