OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Drug Targeting is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Lauric acid-based thermosensitive delivery system for the treatment of head and neck squamous cell carcinoma	67
Nose-to-brain delivery of transferrin-modified carmustine-loaded iron nanoparticles for enhanced glioblastoma treatment	54
Significant metabolic alterations in patients with hepatitis B virus replication observed via serum untargeted metabolomics shed new light on hepatitis B virus infection	43
Polymyxin B delivery systems: smart solutions for improved antibacterial activity and reduced toxicity	40
Cancer cell membrane camouflaging mesoporous nanoplatform interfering with cellular redox homeostasis to amplify photodynamic therapy on oral carcinoma	39
Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches	38
Advancement in transporter-oriented nanoplatforms for cancer therapy	32
Combined photodynamic therapy and hollow microneedle approach for effective non-invasive delivery of hypericin for the management of imiquimod-induced psoriasis	31
Advances in targeted therapy for triple-negative breast cancer: a review of key antigens and recent advances	31
Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases	29
Advances in nanomedicine for retinal drug delivery: overcoming barriers and enhancing therapeutic outcomes	28
Correction	27
Chitosan–β-glycerophosphate thermogelling microneedles for transdermal contraceptive delivery of levonorgestrel	27
Trends in iron oxide nanoparticles: a nano-platform for theranostic application in breast cancer	26
Emerging role of ferroptosis in diabetic retinopathy: a review	26
Role of curcumin and its nanoformulations in the treatment of neurological diseases through the effects on stem cells	25
Improved antidiabetic potential of quercetin-loaded chitosan–lecithin nanoparticles for effective glycaemic control	24
Exosomes derived from cancer cells relieve inflammatory bowel disease in mice	22
Correction	22
Ferroptosis-targeting drugs in breast cancer	21
Sequential targeting dual-responsive magnetic nanoparticle for improved therapy of lung metastatic breast cancer	21
Micro and nanorobot-based drug delivery: an overview	21
Absorption enhancer approach for protein delivery by various routes of administration: a rapid review	21
Engineered extracellular vesicle with RAGE-antagonist peptide for delivery of anti-miRNA155 oligonucleotides to inflammatory lung cells	21
Interactions and communications in lung tumour microenvironment: chemo/radiotherapy resistance mechanisms and therapeutic targets	21

Stimulus-responsive peptide hydrogels: a safe and least invasive administration approach for tumor treatment	20
Erythrocyte-derived liposomes for the treatment of inflammatory diseases	19
Targeting lipopolysaccharides in gram-negative sepsis: therapeutic advances and challenges	19
Redox responsive functionalised mesoporous silica nanoparticle for targeted drug delivery of doxorubicin	19
Recent progress in biomimetic nanomedicines based on versatile targeting strategy for atherosclerosis therapy	19
Identifying factors controlling cellular uptake of gold nanoparticles by machine learning	18
Redefining hepatocellular carcinoma treatment: nanotechnology meets tumor immune microenvironment	18
Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro , and in vivo	18
siRNA targeting PARP-1 alleviates diabetic peripheral neuropathy in a streptozotocin-induced rat model	17
Emerging trends in viral infection inhibition using a chitosan-based drug delivery system	17
Comprehensive insights into herbal P-glycoprotein inhibitors and nanoformulations for improving anti-retroviral therapy efficacy	17
pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery	16
Formulation, optimisation, and evaluation of Lornoxicam-loaded Novasomes for targeted ulcerative colitis therapy: in vitro and in vivo investigations	16
Isoform-specific vs. isoform-universal drug targeting: a new targeting paradigm illustrated by new anti-ICAM-1 antibodies	16
Harnessing the synergistic potential of NK1R antagonists and selective COX-2 inhibitors for simultaneous targeting of TNBC cells and cancer stem cells	16
Crafting two-dimensional materials for contrast agents, drug, and heat delivery applications through green technologies	16
In vivo application of magnetic molecularly imprinted polymer in rheumatoid arthritis rat model	16
Targeted delivery of epirubicin to cancerous cell using copper sulphide nanoparticle coated with polyarginine and 5TR1 aptamer	15
Combination therapy based on targeted nano drug co-delivery systems for liver fibrosis treatment: a review	15
Lipo/TK-CDN/TPP/Y6 nanoparticles inhibit cutaneous melanoma formation	15
From adhesion to invasion: the multifaceted roles of Mycobacterium tuberculosis lipoproteins	15
The role of green synthesis metal and metal oxide nanoparticles in oral cancer therapy: a review	15
Non-coding RNAs enhance the apoptosis efficacy of therapeutic agents used for the treatment of glioblastoma multiform	14
An overview of phospholipid enriched-edge activator-based vesicle nanocarriers: new paradigms to treat skin cancer	14
L-Carnosine loaded chondroitin sulphate functionalized proposomes as an effective tool for transdermal rheumatoid arthritis management	14
microRNAs: critical targets for treating rheumatoid arthritis angiogenesis	14
Emerging biologics for the treatment of pulmonary arterial hypertension	14
Advances, challenge and prospects in cell-mediated nanodrug delivery for cancer therapy: a review	13
Multi-strategic approaches for enhancing active transportation using self-emulsifying drug delivery system	13
Folate receptor-mediated targeted therapy for rheumatoid arthritis by methotrexate-phospholipid complex nano-emulsions	13
Research progress of p38 as a new therapeutic target against morphine tolerance and the current status of therapy of morphine tolerance	13
Angiopep-2 modified dual drug-loaded liposomes with brain targeting functionality mitigate Alzheimer’s disease-related symptoms in APP/PS-1 mice	13
Drug repurposing strategies and key challenges for COVID-19 management	12
Mesencephalic astrocyte-derived neurotrophic factor restores blood–brain barrier integrity of aged mice after ischaemic stroke/reperfusion through anti-inflammation via TLR4/MyD88/NF-κB pathway	12
Recent developments in nanoparticles for the treatment of diabetes	12
Smart design and preclinical evaluation of folate-functionalized mesoporous nanoparticles for targeted paclitaxel delivery in cancer therapy	12
Study on lipid nanomicelles targeting placenta for the treatment of preeclampsia	12
A novel micellar carrier to reverse multidrug resistance of tumours: TPGS derivatives with end-grafted cholesterol	12
Smart delivery of epirubicin to cancer cells using aptamer-modified ferritin nanoparticles	12
MicroRNA-206 inhibition and activation of the AMPK/Nampt signalling pathway enhance sevoflurane post-conditioning-induced amelioration of myocardial ischaemia/reperfusion injury	12
Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson’s disease mouse model	12
Recent advances in curcumin-based nanoformulations in diabetes	12
The Golgi apparatus as a strategic target in cancer: mechanisms, diagnosis and therapeutic opportunities	12
Pulmonary delivery of a recombinant RAGE antagonist peptide derived from high-mobility group box-1 in a bleomycin-induced pulmonary fibrosis animal model	12
Methotrexate-Loaded solid lipid nanoparticles enhance the viability of cutaneous flaps: potential for surgical wound healing	12
Exploring the translocation behaviours in vivo of herpetrione amorphous nanoparticles via oral delivery	12
Lymphatic targeting for therapeutic application using nanoparticulate systems	11
Green synthesis of magnesium oxide nanoparticles using the extract of Falcaria vulgaris to enhance the healing of burn wounds	11
Boosting breast cancer immunotherapy through targeted siRNA delivery and sequential chemotherapy	11
Edoxaban enfolded beta-1,4-poly- d -glucosamine nanoparticles for targeting eponym Stuart–Prower factor for treatment of venous thrombosis	11

ceRNA networks in gynecological cancers progression and resistance	11
In vitro studies support clinical trials showing platelet-rich fibrin-mediated local delivery of antibiotics improves outcomes in impacted mandibular third molar surgery	11
Targeted therapy of tumour microenvironment by gold nanoparticles as a new therapeutic approach	11
ROS1-positive non-small cell lung cancer (NSCLC): biology, diagnostics, therapeutics and resistance	11
Calpeptin promotes osteogenesis through the Dlx3–RUNX2 pathway: in vitro and in vivo evidence for a dual-action osteoporosis therapy	10
The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion	10
Efficient drug delivery by novel cell-penetrating peptide derived from Midkine, with two heparin binding sites braced by a length-specific helix	10
Development of mRNA nano-vaccines for COVID-19 prevention and its biochemical interactions with various disease conditions and age groups	10
Nanotransethosomal dual-drug loaded gel of methotrexate and mangiferin as a potent synergistic intervention for rheumatoid arthritis via transdermal delivery	10
Advancements in colorectal cancer immunotherapy: from CAR-T cells to exosome-based therapies	9
A paradigm use of monoclonal antibodies-conjugated nanoparticles in breast cancer treatment: current status and potential approaches	9
Nanoparticle-Based gene therapy strategies in retinal delivery	9
Mannosylated chitosan-decorated PLGA nanoparticles for targeted pulmonary delivery of isoniazid: a promising approach in the treatment of tuberculosis	9
Role of liposomes in chemoimmunotherapy of breast cancer	9
Olaparib@human serum albumin nanoparticles as sustained drug-releasing tumour-targeting nanomedicine to inhibit growth and metastasis in the mouse model of triple-negative breast cancer	8
Empagliflozin alleviates myocardial I/R injury and cardiomyocyte apoptosis via inhibiting ER stress-induced autophagy and the PERK/ATF4/Beclin1 pathway	8
Advancement on nanoparticles-based approaches for the management of rheumatoid arthritis (RA): molecular mechanism, toxicity, and clinical perspectives	8
Anti-GPC3 antibody and cell-penetrating peptide CPP44 dual-ligand modified liposomes for targeted delivery of arsenic trioxide in the treatment of hepatocellular carcinoma	8
Development of linagliptin-loaded liposomes using aspartic acid conjugate for bone-targeted delivery to combat osteoporosis	8
Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target	8
Macrophage membrane biomimetic drug delivery system: for inflammation targeted therapy	8
Light mediated drug delivery systems: a review	8
Recent advancements in nanomedicine based lipid metabolism for tumour immunotherapy	8
Integrating machine learning and multitargeted drug design to combat antimicrobial resistance: a systematic review	7
Aptamers: ushering in new hopes in targeted glioblastoma therapy	7
Exploring the potential of ferulic acid-loaded nanostructured lipid carriers: angiotensin inhibition via docking, formulation and pharmacokinetic and pharmacodynamics studies	7
Ofirnoflast: a first-in-class NEK7-targeted inhibitor of the NLRP3 inflammasome	7
Niosomal formulation for antibacterial applications	7
Methodological advances in liposomal encapsulation efficiency determination: systematic review and analysis	7
Enhanced pharmacokinetic approach for anastrozole via macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for oestrogen-positive breast cance	7
Legumain protease-sheddable PEGylated, tuftsin-modified nanoparticles for selective targeting to tumour-associated macrophages	7
Albumin-encapsulated HSP90-PROTAC BP3 nanoparticles not only retain protein degradation ability but also enhance the antitumour activity of BP3 in vivo	7
Octreotide and Octreotide-derived delivery systems	7
A platelet-cloaking tetramethylprazine-loaded microemulsion for improved therapy of myocardial ischaemia/reperfusion injury	7
Fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced limosomes: a novel paradigm for preventing UVB-induced skin photoaging	7
2,2,6,6-tetramethylpiperidin-1-oxyl: a new potential targeted ligand based on lipid peroxidation for targeted drug delivery	7
Chemical modification of curcumin increases its potency against hypopharyngeal carcinoma	7
Patient-derived organoid models of malignant phyllodes tumours for drug sensitivity testing and identification of targeted therapeutic strategies	7
DOX-loaded mesoporous hydroxyapatite modified by hyaluronic acid can achieve efficient targeted therapy for lung cancer	7
Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells	7