OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Drug Targeting is 6. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Lauric acid-based thermosensitive delivery system for the treatment of head and neck squamous cell carcinoma	62
Advancement in transporter-oriented nanoplatforms for cancer therapy	50
Advances in targeted therapy for triple-negative breast cancer: a review of key antigens and recent advances	42
Methods for fabricating oxygen releasing biomaterials	37
Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches	36
Cancer cell membrane camouflaging mesoporous nanoplatform interfering with cellular redox homeostasis to amplify photodynamic therapy on oral carcinoma	32
Polymyxin B Delivery Systems: Smart Solutions for Improved Antibacterial Activity and Reduced Toxicity	31
Combined photodynamic therapy and hollow microneedle approach for effective non-invasive delivery of hypericin for the management of imiquimod-induced psoriasis	30
Significant metabolic alterations in patients with hepatitis B virus replication observed via serum untargeted metabolomics shed new light on hepatitis B virus infection	29
Nose-to-brain delivery of transferrin-modified carmustine-loaded iron nanoparticles for enhanced glioblastoma treatment	28
Novel strategies for the fight of Alzheimer’s disease targeting amyloid-β protein	26
Role of curcumin and its nanoformulations in the treatment of neurological diseases through the effects on stem cells	26
Chitosan-β-Glycerophosphate Thermo-gelling Microneedles for Transdermal Contraceptive Delivery of Levonorgestrel	26
Correction	24
Trends in iron oxide nanoparticles: a nano-platform for theranostic application in breast cancer	24
Emerging role of ferroptosis in diabetic retinopathy: a review	22
Improved antidiabetic potential of quercetin-loaded chitosan–lecithin nanoparticles for effective glycaemic control	22
Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases	22
Advances in nanomedicine for retinal drug delivery: overcoming barriers and enhancing therapeutic outcomes	21
Sequential targeting dual-responsive magnetic nanoparticle for improved therapy of lung metastatic breast cancer	20
Interactions and communications in lung tumour microenvironment: chemo/radiotherapy resistance mechanisms and therapeutic targets	20
Correction	20
Absorption enhancer approach for protein delivery by various routes of administration: a rapid review	20
Exosomes derived from cancer cells relieve inflammatory bowel disease in mice	20
Ferroptosis-targeting drugs in breast cancer	19

Micro and nanorobot-based drug delivery: an overview	19
Erythrocyte-derived liposomes for the treatment of inflammatory diseases	19
Engineered extracellular vesicle with RAGE-antagonist peptide for delivery of anti-miRNA155 oligonucleotides to inflammatory lung cells	19
Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro , and in vivo	18
Stimulus-responsive peptide hydrogels: a safe and least invasive administration approach for tumor treatment	17
Recent progress in biomimetic nanomedicines based on versatile targeting strategy for atherosclerosis therapy	17
In vivo application of magnetic molecularly imprinted polymer in rheumatoid arthritis rat model	16
Identifying factors controlling cellular uptake of gold nanoparticles by machine learning	16
siRNA targeting PARP-1 alleviates diabetic peripheral neuropathy in a streptozotocin-induced rat model	15
Formulation, optimisation, and evaluation of Lornoxicam-loaded Novasomes for targeted ulcerative colitis therapy: in vitro and in vivo investigations	15
Crafting two-dimensional materials for contrast agents, drug, and heat delivery applications through green technologies	15
Emerging trends in viral infection inhibition using a chitosan-based drug delivery system	15
Redefining hepatocellular carcinoma treatment: nanotechnology meets tumor immune microenvironment	15
Isoform-specific vs. isoform-universal drug targeting: a new targeting paradigm illustrated by new anti-ICAM-1 antibodies	15
Comprehensive insights into herbal P-glycoprotein inhibitors and nanoformulations for improving anti-retroviral therapy efficacy	15
Targeting Lipopolysaccharides in Gram-negative Sepsis: Therapeutic Advances and Challenges	15
pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery	14
An overview of phospholipid enriched-edge activator-based vesicle nanocarriers: new paradigms to treat skin cancer	14
Harnessing the synergistic potential of NK1R antagonists and selective COX-2 inhibitors for simultaneous targeting of TNBC cells and cancer stem cells	14
Emerging biologics for the treatment of pulmonary arterial hypertension	13
Targeted delivery of epirubicin to cancerous cell using copper sulphide nanoparticle coated with polyarginine and 5TR1 aptamer	13
Non-coding RNAs enhance the apoptosis efficacy of therapeutic agents used for the treatment of glioblastoma multiform	13
From adhesion to invasion: the multifaceted roles of Mycobacterium tuberculosis lipoproteins	13
Advances, challenge and prospects in cell-mediated nanodrug delivery for cancer therapy: a review	13
Combination therapy based on targeted nano drug co-delivery systems for liver fibrosis treatment: a review	13
The role of green synthesis metal and metal oxide nanoparticles in oral cancer therapy: a review	13
Recent developments in nanoparticles for the treatment of diabetes	12
Lipo/TK-CDN/TPP/Y6 nanoparticles inhibit cutaneous melanoma formation	12
Folate receptor-mediated targeted therapy for rheumatoid arthritis by methotrexate-phospholipid complex nano-emulsions	12
Multi-strategic approaches for enhancing active transportation using self-emulsifying drug delivery system	12
microRNAs: critical targets for treating rheumatoid arthritis angiogenesis	12
Research progress of p38 as a new therapeutic target against morphine tolerance and the current status of therapy of morphine tolerance	12
Angiopep-2 modified dual drug-loaded liposomes with brain targeting functionality mitigate Alzheimer’s disease-related symptoms in APP/PS-1 mice	12
Drug repurposing strategies and key challenges for COVID-19 management	11
Study on lipid nanomicelles targeting placenta for the treatment of preeclampsia	11
Edoxaban enfolded beta-1,4-poly- d -glucosamine nanoparticles for targeting eponym Stuart–Prower factor for treatment of venous thrombosis	11
Smart delivery of epirubicin to cancer cells using aptamer-modified ferritin nanoparticles	11
Mesencephalic astrocyte-derived neurotrophic factor restores blood–brain barrier integrity of aged mice after ischaemic stroke/reperfusion through anti-inflammation via TLR4/MyD88/NF-κB pathway	11
The Golgi apparatus as a strategic target in cancer: mechanisms, diagnosis and therapeutic opportunities	11
Boosting breast cancer immunotherapy through targeted siRNA delivery and sequential chemotherapy	11
A novel micellar carrier to reverse multidrug resistance of tumours: TPGS derivatives with end-grafted cholesterol	11
Recent advances in curcumin-based nanoformulations in diabetes	11
Exploring the translocation behaviours in vivo of herpetrione amorphous nanoparticles via oral delivery	11
MicroRNA-206 inhibition and activation of the AMPK/Nampt signalling pathway enhance sevoflurane post-conditioning-induced amelioration of myocardial ischaemia/reperfusion injury	11
Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson’s disease mouse model	10
Green synthesis of magnesium oxide nanoparticles using the extract of Falcaria vulgaris to enhance the healing of burn wounds	10
ceRNA networks in gynecological cancers progression and resistance	10
Methotrexate-Loaded solid lipid nanoparticles enhance the viability of cutaneous flaps: potential for surgical wound healing	10
Lymphatic targeting for therapeutic application using nanoparticulate systems	10
Targeted therapy of tumour microenvironment by gold nanoparticles as a new therapeutic approach	10

In vitro studies support clinical trials showing platelet-rich fibrin-mediated local delivery of antibiotics improves outcomes in impacted mandibular third molar surgery	10
Smart design and preclinical evaluation of folate-functionalized mesoporous nanoparticles for targeted paclitaxel delivery in cancer therapy	10
Efficient drug delivery by novel cell-penetrating peptide derived from Midkine, with two heparin binding sites braced by a length-specific helix	9
Nanotransethosomal dual-drug loaded gel of methotrexate and mangiferin as a potent synergistic intervention for rheumatoid arthritis via transdermal delivery	9
Pulmonary delivery of a recombinant RAGE antagonist peptide derived from high-mobility group box-1 in a bleomycin-induced pulmonary fibrosis animal model	9
Development of linagliptin-loaded liposomes using aspartic acid conjugate for bone-targeted delivery to combat osteoporosis	9
Role of liposomes in chemoimmunotherapy of breast cancer	9
Development of mRNA nano-vaccines for COVID-19 prevention and its biochemical interactions with various disease conditions and age groups	9
Nanoparticle-Based gene therapy strategies in retinal delivery	9
Anti-GPC3 antibody and cell-penetrating peptide CPP44 dual-ligand modified liposomes for targeted delivery of arsenic trioxide in the treatment of hepatocellular carcinoma	9
ROS1-positive non-small cell lung cancer (NSCLC): biology, diagnostics, therapeutics and resistance	9
Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target	8
Empagliflozin alleviates myocardial I/R injury and cardiomyocyte apoptosis via inhibiting ER stress-induced autophagy and the PERK/ATF4/Beclin1 pathway	8
Calpeptin promotes osteogenesis through the Dlx3–RUNX2 pathway: in vitro and in vivo evidence for a dual-action osteoporosis therapy	8
A paradigm use of monoclonal antibodies-conjugated nanoparticles in breast cancer treatment: current status and potential approaches	8
Olaparib@human serum albumin nanoparticles as sustained drug-releasing tumour-targeting nanomedicine to inhibit growth and metastasis in the mouse model of triple-negative breast cancer	8
The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion	8
Advancements in colorectal cancer immunotherapy: from CAR-T cells to exosome-based therapies	8
Light mediated drug delivery systems: a review	8
Integrating machine learning and multitargeted drug design to combat antimicrobial resistance: a systematic review	7
Macrophage membrane biomimetic drug delivery system: for inflammation targeted therapy	7
Mannosylated chitosan-decorated PLGA nanoparticles for targeted pulmonary delivery of Isoniazid: A promising approach in the treatment of Tuberculosis.	7
Legumain protease-sheddable PEGylated, tuftsin-modified nanoparticles for selective targeting to tumour-associated macrophages	7
Albumin-encapsulated HSP90-PROTAC BP3 nanoparticles not only retain protein degradation ability but also enhance the antitumour activity of BP3 in vivo	7
Chemical modification of curcumin increases its potency against hypopharyngeal carcinoma	7
Advancements in curcumin-loaded PLGA nanoparticle delivery systems: progressive strategies in cancer therapy	6
Octreotide and Octreotide-derived delivery systems	6
2,2,6,6-tetramethylpiperidin-1-oxyl: a new potential targeted ligand based on lipid peroxidation for targeted drug delivery	6
Ofirnoflast: a first-in-class NEK7-targeted inhibitor of the NLRP3 inflammasome	6
Patient-derived organoid models of malignant phyllodes tumours for drug sensitivity testing and identification of targeted therapeutic strategies	6
Protein biomarker modulation and wound healing efficacy of mentha piperita-based green-synthesized silver nanoparticles in alloxan-induced diabetic rats	6
Perspectives of metformin use in endometrial cancer and other gynaecological malignancies	6
Preparation of cationic liposomes loaded with Sirtuin 6 plasmid for the treatment of arthritis in rats	6
Celastrol nano-emulsions selectively regulate apoptosis of synovial macrophage for alleviating rheumatoid arthritis	6
A platelet-cloaking tetramethylprazine-loaded microemulsion for improved therapy of myocardial ischaemia/reperfusion injury	6
Exploring the potential of ferulic acid-loaded nanostructured lipid carriers: angiotensin inhibition via docking, formulation and pharmacokinetic and pharmacodynamics studies	6
DOX-loaded mesoporous hydroxyapatite modified by hyaluronic acid can achieve efficient targeted therapy for lung cancer	6
Recent advancements in nanomedicine based lipid metabolism for tumour immunotherapy	6
Methodological advances in liposomal encapsulation efficiency determination: systematic review and analysis	6
Bone morphogenetic protein (BMP)9 in cancer development: mechanistic, diagnostic, and therapeutic approaches?	6
Molecular and cellular biology of PCSK9: impact on glucose homeostasis	6
Research progress of microneedle drug delivery system in the treatment of autoimmune diseases	6
Molecular mechanism of Wilms tumour 1-associated protein in diabetes-related dry eye disease by mediating m6A methylation modification of lncRNA NEAT1	6
Cationic liposome decorated with cyclic RGD peptide for targeted delivery of anti-STAT3 siRNA to melanoma cancer cells	6
Niosomal formulation for antibacterial applications	6
Aptamers: ushering in new hopes in targeted glioblastoma therapy	6
Enhanced pharmacokinetic approach for anastrozole via macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for oestrogen-positive breast cance	6
A review of recombinant HER3 affibodies with an effective diagnostic view of cancer cells	6
Efficacy of intranasal delivery of VEGFR inhibitors to cervical lymph nodes for inhibiting tongue cancer metastasis in mice	6
Comparison of a poloxamer-based thermally sensitive gel and an HPMC-based standard gel used to increase sildenafil citrate retention in the uterus	6