OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Drug Targeting is 8. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
Nose-to-brain delivery of transferrin-modified carmustine-loaded iron nanoparticles for enhanced glioblastoma treatment	76
Polymyxin B delivery systems: smart solutions for improved antibacterial activity and reduced toxicity	61
Cancer cell membrane camouflaging mesoporous nanoplatform interfering with cellular redox homeostasis to amplify photodynamic therapy on oral carcinoma	49
Lauric acid-based thermosensitive delivery system for the treatment of head and neck squamous cell carcinoma	44
Advancement in transporter-oriented nanoplatforms for cancer therapy	43
Advances in targeted therapy for triple-negative breast cancer: a review of key antigens and recent advances	38
Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches	36
Combined photodynamic therapy and hollow microneedle approach for effective non-invasive delivery of hypericin for the management of imiquimod-induced psoriasis	33
Advances in nanomedicine for retinal drug delivery: overcoming barriers and enhancing therapeutic outcomes	31
Role of curcumin and its nanoformulations in the treatment of neurological diseases through the effects on stem cells	31
Trends in iron oxide nanoparticles: a nano-platform for theranostic application in breast cancer	29
Targeting Nrf2 signaling pathway: new therapeutic strategy for cardiovascular diseases	29
Beyond drug delivery: nanoparticles as active modulators of immunometabolism for treating inflammatory diseases	28
Correction	28
Improved antidiabetic potential of quercetin-loaded chitosan–lecithin nanoparticles for effective glycaemic control	26
Emerging role of ferroptosis in diabetic retinopathy: a review	26
Chitosan–β-glycerophosphate thermogelling microneedles for transdermal contraceptive delivery of levonorgestrel	25
Exosomes derived from cancer cells relieve inflammatory bowel disease in mice	24
Sequential targeting dual-responsive magnetic nanoparticle for improved therapy of lung metastatic breast cancer	24
The role of MSC-derived exosomes in immune modulation and regenerative medicine	23
Correction	23
Interactions and communications in lung tumour microenvironment: chemo/radiotherapy resistance mechanisms and therapeutic targets	23
Engineered extracellular vesicle with RAGE-antagonist peptide for delivery of anti-miRNA155 oligonucleotides to inflammatory lung cells	23
Ferroptosis-targeting drugs in breast cancer	23
Absorption enhancer approach for protein delivery by various routes of administration: a rapid review	23

Pravastatin-Loaded nanostructured lipid carriers: formulation optimization and in-vivo assessment for antihyperlipidaemic effect in rats	22
Crafting two-dimensional materials for contrast agents, drug, and heat delivery applications through green technologies	22
In vivo application of magnetic molecularly imprinted polymer in rheumatoid arthritis rat model	21
Redefining hepatocellular carcinoma treatment: nanotechnology meets tumor immune microenvironment	20
Isoform-specific vs. isoform-universal drug targeting: a new targeting paradigm illustrated by new anti-ICAM-1 antibodies	20
Stimulus-responsive peptide hydrogels: a safe and least invasive administration approach for tumor treatment	20
Recent progress in biomimetic nanomedicines based on versatile targeting strategy for atherosclerosis therapy	19
Redox responsive functionalised mesoporous silica nanoparticle for targeted drug delivery of doxorubicin	19
Thermosensitive, injectable, biocompatible epigallocatechin gallate liposomes/modified chitosan composite hydrogel for efficient skin repairing	19
Comprehensive insights into herbal P-glycoprotein inhibitors and nanoformulations for improving anti-retroviral therapy efficacy	18
Therapeutic potential of mesenchymal stem cells-derived exosomes loaded with elemental or nano selenium on diabetic nephropathy	18
Formulation, optimisation, and evaluation of Lornoxicam-loaded Novasomes for targeted ulcerative colitis therapy: in vitro and in vivo investigations	18
Emerging trends in viral infection inhibition using a chitosan-based drug delivery system	18
Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro , and in vivo	18
siRNA targeting PARP-1 alleviates diabetic peripheral neuropathy in a streptozotocin-induced rat model	18
Targeting lipopolysaccharides in gram-negative sepsis: therapeutic advances and challenges	17
pH-responsive self-assembled nanoparticles for tumor-targeted drug delivery	17
Identifying factors controlling cellular uptake of gold nanoparticles by machine learning	17
Lipo/TK-CDN/TPP/Y6 nanoparticles inhibit cutaneous melanoma formation	16
Harnessing the synergistic potential of NK1R antagonists and selective COX-2 inhibitors for simultaneous targeting of TNBC cells and cancer stem cells	16
The role of green synthesis metal and metal oxide nanoparticles in oral cancer therapy: a review	15
Targeted delivery of epirubicin to cancerous cell using copper sulphide nanoparticle coated with polyarginine and 5TR1 aptamer	15
L-Carnosine loaded chondroitin sulphate functionalized proposomes as an effective tool for transdermal rheumatoid arthritis management	15
Targeting osteoporosis: Rutin-loaded proniosomes and their role in OPG/RANKL modulation in ovariectomized rats	15
Advances, challenge and prospects in cell-mediated nanodrug delivery for cancer therapy: a review	14
From adhesion to invasion: the multifaceted roles of Mycobacterium tuberculosis lipoproteins	14
microRNAs: critical targets for treating rheumatoid arthritis angiogenesis	14
Angiopep-2 modified dual drug-loaded liposomes with brain targeting functionality mitigate Alzheimer’s disease-related symptoms in APP/PS-1 mice	14
Emerging biologics for the treatment of pulmonary arterial hypertension	14
Multi-pathway therapeutics in colorectal cancer: targeting EMT, CSCs, and non-apoptotic cell death for drug resistance reversal	13
The Golgi apparatus as a strategic target in cancer: mechanisms, diagnosis and therapeutic opportunities	13
Recent advances in curcumin-based nanoformulations in diabetes	13
Exploring the translocation behaviours in vivo of herpetrione amorphous nanoparticles via oral delivery	13
Research progress of p38 as a new therapeutic target against morphine tolerance and the current status of therapy of morphine tolerance	13
A novel micellar carrier to reverse multidrug resistance of tumours: TPGS derivatives with end-grafted cholesterol	13
Folate receptor-mediated targeted therapy for rheumatoid arthritis by methotrexate-phospholipid complex nano-emulsions	13
An overview of phospholipid enriched-edge activator-based vesicle nanocarriers: new paradigms to treat skin cancer	13
Multi-strategic approaches for enhancing active transportation using self-emulsifying drug delivery system	13
Study on lipid nanomicelles targeting placenta for the treatment of preeclampsia	13
Recent developments in nanoparticles for the treatment of diabetes	13
Solvent-free green preparation of niacinamide niosomes for targeting UVB-induced hyperpigmentation: QbD-based optimisation and in vivo assessment	12
Edoxaban enfolded beta-1,4-poly- d -glucosamine nanoparticles for targeting eponym Stuart–Prower factor for treatment of venous thrombosis	12
In vitro studies support clinical trials showing platelet-rich fibrin-mediated local delivery of antibiotics improves outcomes in impacted mandibular third molar surgery	12
Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson’s disease mouse model	12
Methotrexate-Loaded solid lipid nanoparticles enhance the viability of cutaneous flaps: potential for surgical wound healing	12
Green synthesis of magnesium oxide nanoparticles using the extract of Falcaria vulgaris to enhance the healing of burn wounds	12
Boosting breast cancer immunotherapy through targeted siRNA delivery and sequential chemotherapy	12
MicroRNA-206 inhibition and activation of the AMPK/Nampt signalling pathway enhance sevoflurane post-conditioning-induced amelioration of myocardial ischaemia/reperfusion injury	12
Pulmonary delivery of a recombinant RAGE antagonist peptide derived from high-mobility group box-1 in a bleomycin-induced pulmonary fibrosis animal model	12
ceRNA networks in gynecological cancers progression and resistance	11

Nanotransethosomal dual-drug loaded gel of methotrexate and mangiferin as a potent synergistic intervention for rheumatoid arthritis via transdermal delivery	11
A paradigm use of monoclonal antibodies-conjugated nanoparticles in breast cancer treatment: current status and potential approaches	11
Smart design and preclinical evaluation of folate-functionalized mesoporous nanoparticles for targeted paclitaxel delivery in cancer therapy	11
Development of mRNA nano-vaccines for COVID-19 prevention and its biochemical interactions with various disease conditions and age groups	11
Development of linagliptin-loaded liposomes using aspartic acid conjugate for bone-targeted delivery to combat osteoporosis	11
Lymphatic targeting for therapeutic application using nanoparticulate systems	11
ROS1-positive non-small cell lung cancer (NSCLC): biology, diagnostics, therapeutics and resistance	11
Nanoparticle-Based gene therapy strategies in retinal delivery	11
Role of liposomes in chemoimmunotherapy of breast cancer	10
Olaparib@human serum albumin nanoparticles as sustained drug-releasing tumour-targeting nanomedicine to inhibit growth and metastasis in the mouse model of triple-negative breast cancer	10
Anti-GPC3 antibody and cell-penetrating peptide CPP44 dual-ligand modified liposomes for targeted delivery of arsenic trioxide in the treatment of hepatocellular carcinoma	10
Calpeptin promotes osteogenesis through the Dlx3–RUNX2 pathway: in vitro and in vivo evidence for a dual-action osteoporosis therapy	10
Development of venlafaxine hydrochloride nasal thermosensitive in-situ gel with P407/P188: enhanced bioavailability and antidepressant effects in depressive rats	10
Mannosylated chitosan-decorated PLGA nanoparticles for targeted pulmonary delivery of isoniazid: a promising approach in the treatment of tuberculosis	10
Advancements in colorectal cancer immunotherapy: from CAR-T cells to exosome-based therapies	10
Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target	10
Empagliflozin alleviates myocardial I/R injury and cardiomyocyte apoptosis via inhibiting ER stress-induced autophagy and the PERK/ATF4/Beclin1 pathway	10
Macrophage membrane biomimetic drug delivery system: for inflammation targeted therapy	10
The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion	10
Advancement on nanoparticles-based approaches for the management of rheumatoid arthritis (RA): molecular mechanism, toxicity, and clinical perspectives	9
Chemical modification of curcumin increases its potency against hypopharyngeal carcinoma	9
Recent advancements in nanomedicine based lipid metabolism for tumour immunotherapy	9
DOX-loaded mesoporous hydroxyapatite modified by hyaluronic acid can achieve efficient targeted therapy for lung cancer	9
Albumin-encapsulated HSP90-PROTAC BP3 nanoparticles not only retain protein degradation ability but also enhance the antitumour activity of BP3 in vivo	9
Fisetin topical delivery via ascorbyl palmitate/hyaluronan-enhanced limosomes: a novel paradigm for preventing UVB-induced skin photoaging	9
Octreotide and Octreotide-derived delivery systems	9
Integrating machine learning and multitargeted drug design to combat antimicrobial resistance: a systematic review	9
2,2,6,6-tetramethylpiperidin-1-oxyl: a new potential targeted ligand based on lipid peroxidation for targeted drug delivery	9
Aptamers: ushering in new hopes in targeted glioblastoma therapy	9
Patient-derived organoid models of malignant phyllodes tumours for drug sensitivity testing and identification of targeted therapeutic strategies	9
Enhanced pharmacokinetic approach for anastrozole via macromolecule-based silk fibroin nanoparticles incorporated in situ injectables for oestrogen-positive breast cance	9
Venlafaxine suppressed PD-L1 expression through oxidative stress and improved anti-tumour immune responses in melanoma mice	8
Nanotechnology-driven approaches for the early detection and targeted treatment of Alzheimer’s disease	8
Exploring the potential of ferulic acid-loaded nanostructured lipid carriers: angiotensin inhibition via docking, formulation and pharmacokinetic and pharmacodynamics studies	8
Formulation and optimisation of nanoemulsions for enhancing topical delivery of methotrexate in CFA induced arthritis rat model	8
Comparison of a poloxamer-based thermally sensitive gel and an HPMC-based standard gel used to increase sildenafil citrate retention in the uterus	8
Synergistic antibacterial and antibiofilm activity of N-acetylcysteine combined with niosomal recombinant lysostaphin against MRSA Staphylococcus aureus	8
Efficacy of intranasal delivery of VEGFR inhibitors to cervical lymph nodes for inhibiting tongue cancer metastasis in mice	8
Protein biomarker modulation and wound healing efficacy of mentha piperita-based green-synthesized silver nanoparticles in alloxan-induced diabetic rats	8
Platelet-rich plasma ameliorates knee osteoarthritis in rats by modulating the abundance of gut Lactobacillus murinus	8
Fabrication of crosslinker-free chitosan-HPMC hydrogel for implant coating: a new approach for the treatment of osteomyelitis	8
Celastrol nano-emulsions selectively regulate apoptosis of synovial macrophage for alleviating rheumatoid arthritis	8
Preparation of cationic liposomes loaded with Sirtuin 6 plasmid for the treatment of arthritis in rats	8
Advanced co-delivery nanocarriers to overcome drug resistance in breast cancer: carrier-mediated synergistic treatment by chemotherapy and gene therapy	8
Dectin-1 receptor-targeted β-glucan microparticles as dry powder inhalation system – a novel strategy to improve lung pharmacokinetics of rifampicin	8
Bone morphogenetic protein (BMP)9 in cancer development: mechanistic, diagnostic, and therapeutic approaches?	8
A review of recombinant HER3 affibodies with an effective diagnostic view of cancer cells	8
Molecular mechanism of Wilms tumour 1-associated protein in diabetes-related dry eye disease by mediating m6A methylation modification of lncRNA NEAT1	8
Ofirnoflast: a first-in-class NEK7-targeted inhibitor of the NLRP3 inflammasome	8
Methodological advances in liposomal encapsulation efficiency determination: systematic review and analysis	8
Molecular and cellular biology of PCSK9: impact on glucose homeostasis	8
Research progress of microneedle drug delivery system in the treatment of autoimmune diseases	8