OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Drug Targeting is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Methotrexate-Loaded solid lipid nanoparticles enhance the viability of cutaneous flaps: potential for surgical wound healing	48
Synergistic cancer treatment using porphyrin-based metal-organic Frameworks for photodynamic and photothermal therapy	47
Artificial intelligence-based molecular property prediction of photosensitising effects of drugs	43
Nano-based drug delivery systems in hepatocellular carcinoma	42
Edoxaban enfolded beta-1,4-poly- d -glucosamine nanoparticles for targeting eponym Stuart–Prower factor for treatment of venous thrombosis	40
Self-nanoemulsifying drug delivery system (SNEDDS) as nano-carrier framework for permeability modulating approaches of BCS class III drug	39
Resveratrol in ulcerative colitis: therapeutic mechanisms, animal model evidence and novel approaches	39
RETRACTED ARTICLE: Melanin-based biomimic photothermal nanoparticles for therapeutic application in diabetic nephropathy	34
Statement of Retraction: Melanin-based biomimic photothermal nanoparticles for therapeutic application in diabetic nephropathy	31
MicroRNA-206 inhibition and activation of the AMPK/Nampt signalling pathway enhance sevoflurane post-conditioning-induced amelioration of myocardial ischaemia/reperfusion injury	29
Emerging targeted therapeutic strategies for the treatment of triple-negative breast cancer	28
Progress in tumour-targeted drug delivery based on cell-penetrating peptides	26
Novel pH-responsive alginate-stabilized curcumin–selenium–ZIF-8 nanocomposites for synergistic breast cancer therapy	25
ROS1-positive non-small cell lung cancer (NSCLC): biology, diagnostics, therapeutics and resistance	25
Cancer stem cell biomarkers and related signalling pathways	24
Advances in autophagy as a target in the treatment of tumours	24
State-of-the-art drug delivery system to target the lymphatics	23
Research progress of exosomes as drug carriers in cancer and inflammation	21
Lauric acid-based thermosensitive delivery system for the treatment of head and neck squamous cell carcinoma	21
Combined photodynamic therapy and hollow microneedle approach for effective non-invasive delivery of hypericin for the management of imiquimod-induced psoriasis	21
Delivery of MERS antigen encapsulated in α-GalCer-bearing liposomes elicits stronger antigen-specific immune responses	20
Advancement in transporter-oriented nanoplatforms for cancer therapy	20
In vitro studies support clinical trials showing platelet-rich fibrin-mediated local delivery of antibiotics improves outcomes in impacted mandibular third molar surgery	20
Role of exosomes in tumour growth, chemoresistance and immunity: state-of-the-art	19
Cell-based immunotherapy in oesophageal cancer	19

Significant metabolic alterations in patients with hepatitis B virus replication observed via serum untargeted metabolomics shed new light on hepatitis B virus infection	18
Effects and mechanisms of natural plant active compounds for the treatment of osteoclast-mediated bone destructive diseases	18
Pulmonary delivery of a recombinant RAGE antagonist peptide derived from high-mobility group box-1 in a bleomycin-induced pulmonary fibrosis animal model	18
Her-2-directed systemic delivery of fatty acid synthase (FASN) siRNA with novel liposomal carrier systems in the breast cancer mouse model	18
Impact of tumoral structure and bacterial species on growth and biodistribution of live bacterial therapeutics in xenografted tumours	17
Targeting E7 antigen to the endoplasmic reticulum degradation pathway promotes a potent therapeutic antitumor effect	17
Nanoreactor activated in situ for starvation-chemodynamic therapy of breast cancer	17
Valeric acid reduction by chitosan oligosaccharide induces autophagy in a Parkinson’s disease mouse model	17
Multifunctional metal complex-based gene delivery for tumour immune checkpoint blockade combination therapy	16
Factors of faecal microbiota transplantation applied to cancer management	15
ceRNA networks in gynecological cancers progression and resistance	15
Metformin combats obesity by targeting FTO in an m⁶A-YTHDF2-dependent manner	15
Development and characterization of a novel neutralizing scFv vectored immunoprophylaxis against botulinum toxin type A	15
Cancer cell membrane camouflaging mesoporous nanoplatform interfering with cellular redox homeostasis to amplify photodynamic therapy on oral carcinoma	15
Progress in research and development of temozolomide brain-targeted preparations: a review	14
Indocyanine green-loaded N-doped carbon quantum dot nanoparticles for effective photodynamic therapy and cell imaging of melanoma cancer: in vitro , ex vi	14
Desmethoxycurcumin aids IFNα’s anti-HBV activity by antagonising CRYAB reduction and stabilising IFNAR1 protein	14
Ferroptosis in renal fibrosis: a mini-review	14
Regulation of IFP in solid tumours through acoustic pressure to enhance infiltration of nanoparticles of various sizes	13
The applications of targeted delivery for gene therapies in hearing loss	13
Hybrid nano-stimulator for specific amplification of oxidative stress and precise tumour treatment	13
Evaluation of anti-diabetic effects of glimepiride/metformin cocrystal	13
Evaluation of mRNA lipoplexes prepared using modified ethanol injection method as a tumour vaccine	13
Epigenetic modulation: Research progress on histone acetylation levels in major depressive disorders	12
Recent advances in hepatocellular carcinoma therapeutic strategies and imaging-guided treatment	12
Enhanced antitumor activity induced by a DNA vaccine encoding E7 antigen fused to an ERAD-targeting sequence	12
Methods for fabricating oxygen releasing biomaterials	12
Lymphatic targeting for therapeutic application using nanoparticulate systems	12
Harnessing machine learning potential for personalised drug design and overcoming drug resistance	12
Advancing biofilm management through nanoformulation strategies: a review of dosage forms and administration routes	12
Targeted therapy of tumour microenvironment by gold nanoparticles as a new therapeutic approach	11
Hydrogel doped with sinomenine-CeO ₂ nanoparticles for sustained intra-articular therapy in knee osteoarthritis	11
Cetuximab-conjugated PLGA nanoparticles as a prospective targeting therapeutics for non-small cell lung cancer	11
A critical review on the role of nanotheranostics mediated approaches for targeting β amyloid in Alzheimer’s	11
Evaluating the reliability of tumour spheroid-on-chip models for replicating intratumoural drug delivery: considering the role of microfluidic parameters	11
Green synthesis of magnesium oxide nanoparticles using the extract of Falcaria vulgaris to enhance the healing of burn wounds	11
Trimethyl chitosan–cysteine-based nanoparticles as an effective delivery system for portulacerebroside A in the management of hepatocellular carcinoma cells in vitro and	10
Exosome-mediated transfer of circHIPK3 promotes trastuzumab chemoresistance in breast cancer	10
Nanoliposomes as drug delivery systems: safety concerns	10
Ultrasound image-guided gene delivery using three-dimensional diagnostic ultrasound and lipid-based microbubbles	10
Targetting ferroptosis for blood cell-related diseases	10
Design and Formulation of Fast-Dissolving Microneedles for the Rapid Transdermal Delivery of Lorazepam	10
Development of linagliptin-loaded liposomes using aspartic acid conjugate for bone-targeted delivery to combat osteoporosis	9
An all-in-one nanoparticle for overcoming drug resistance: doxorubicin and elacridar co-loaded folate receptor targeted PLGA/MSN hybrid nanoparticles	9
Artificial intelligence for skin permeability prediction: deep learning	9
The combined treatment of gold nanoparticles associated with photobiomodulation accelerate the healing of dermonecrotic lesion	9
Roles and therapeutic targeting of dendritic cells in liver fibrosis	9
Overview of role of survivin in cancer: expression, regulation, functions, and its potential as a therapeutic target	9
Selection of LRP1 ligand phage-displayed single domain antibody that transmigrates BBB	9
Nanoparticle-Based gene therapy strategies in retinal delivery	9

Comprehensive developmental investigation on simvastatin enriched bioactive film forming spray using the quality by design paradigm: a prospective strategy for improved wound healing	9
A paradigm use of monoclonal antibodies-conjugated nanoparticles in breast cancer treatment: current status and potential approaches	9
Targeting cellular energy metabolism- mediated ferroptosis by small molecule compounds for colorectal cancer therapy	9
Pharmaceutical cocrystals: a rising star in drug delivery applications	8
Trends in iron oxide nanoparticles: a nano-platform for theranostic application in breast cancer	8
Igniting tumour microenvironment in triple-negative breast cancer using a mannose/hyaluronic acid dual-coated Ganoderma polysaccharide-superparamagnetic iron oxide nanocomplex for combinational therap	8
Correction	8
Role of liposomes in chemoimmunotherapy of breast cancer	8
Emerging advances in nano-biomaterial assisted amyloid beta chimeric antigen receptor macrophages (CAR-M) therapy: reducing plaque burden in Alzheimer’s disease	8
Folate-conjugated carbon nanotubes as a promising therapeutic approach for targeted cancer therapy	8
Nanotransethosomal dual-drug loaded gel of methotrexate and mangiferin as a potent synergistic intervention for rheumatoid arthritis via transdermal delivery	7
Exploring nalbuphine loaded chitosan nanoparticles for effective pain management through intranasal administration: a comparative study	7
Targeting the lung tumour stroma: harnessing nanoparticles for effective therapeutic interventions	7
Liver-targeted delivery based on prodrug: passive and active approaches	7
Novel strategies for the fight of Alzheimer’s disease targeting amyloid-β protein	7
Epidermal growth factor receptors unveiled: a comprehensive survey on mutations, clinical insights of global inhibitors, and emergence of heterocyclic derivatives as EGFR inhibitors	7
Chitosan tamarind-based nanoparticles as a promising approach for topical application of curcumin intended for burn healing: in vitro and in vivo	7
Geriatric drug delivery ― barriers, current technologies and the road ahead	7
Olaparib@human serum albumin nanoparticles as sustained drug-releasing tumour-targeting nanomedicine to inhibit growth and metastasis in the mouse model of triple-negative breast cancer	7
A bispecific decoy receptor VEGFR-EGFR/Fc binding EGF-like ligands and VEGF shows potent antitumor efficacy	7
Anti-GPC3 antibody and cell-penetrating peptide CPP44 dual-ligand modified liposomes for targeted delivery of arsenic trioxide in the treatment of hepatocellular carcinoma	7
In vivoandin vitroimpact of atorvastatin against myocardial ischaemia-reperfusion injury by upregulation of silent information regulator l and attenuation of endoplasmic reticulum stress	7