OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Genetics is 110. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-07-01 to 2025-07-01.)

Article	Citations
Deciphering the evolutionary dynamics of extrachromosomal DNA in human cancer	1539
Mapping dog behavior	1483
Epigenetic memory in 3D	1218
Temperature-induced RNA recoding in octopus	1020
Toward advances in retinoblastoma genetics in Kenya	934
DNA polymerase ε produces elevated C-to-T mutations at methylated CpG dinucleotides	735
The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes	529
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease	494
Reactivation of embryonic genetic programs in tissue regeneration and disease	478
Role of gene–gene loops in fine-tuning cross-regulation	440
Problems with dystopian representations in genetic futurism	428
Machine learning drives genetic discovery for binge eating disorder	425
Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores	413
GeneMAP enables discovery of metabolic gene function	409
Renal plasticity revealed through reversal of polycystic kidney disease in mice	404
An atlas of genetic determinants of forearm fracture	404
Rare coding variant analysis for human diseases across biobanks and ancestries	383
Understanding liver repair through space and time	381
Complete genomes of six ape species	338
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption	329
Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness	320
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases	317
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways	298
Mitochondrial DNA mosaicism in normal human somatic cells	281
Cicer super-pangenome provides insights into species evolution and agronomic trait loci for crop improvement in chickpea	263

A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation	261
In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization	259
Genome-wide RNA polymerase stalling shapes the transcriptome during aging	253
Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence	253
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development	252
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome	252
Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells	249
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals	247
A biology-aware mutation rate model for human germline	245
Shared genetics of substance use disorders	239
Genes influence complex traits through environments that vary between geographic regions	238
Histone gene editing probes functions of H3K27 modifications in mammals	232
Somatic mutations in the stomach	231
When RNA methylation meets DNA methylation	218
Identification of two intrinsic epithelial subtypes of colorectal cancer	217
Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk	214
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns	212
Epigenomic contributions to tumor cell heterogeneity and plasticity	202
Finding causal genes underlying risk for coronary artery disease	193
Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome	184
Genetic and non-genetic HLA disruption is widespread in lung and breast tumors	182
Finding cancer mutagens using signature analysis	181
Author Correction: The NAT1–bHLH110–CER1/CER1L module regulates heat stress tolerance in rice	181
Author Correction: Pangenome graphs and their applications in biodiversity genomics	180
Safeguard repressor locks hepatocyte identity and blocks liver cancer	180
The Federated European Genome–Phenome Archive as a global network for sharing human genomics data	175
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription	172
Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon	169
Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks	169
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen	168
Interpreting cis-regulatory interactions from large-scale deep neural networks	167
An alternative model for maternal mtDNA inheritance	164
Establishing African genomics and bioinformatics programs through annual regional workshops	163
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity	159
Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors	158
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas	156
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits	156
Bayesian estimation of gene constraint from an evolutionary model with gene features	153
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction	152
Increasing diversity in genomics requires investment in equitable partnerships and capacity building	151
APOBEC mutagenesis is a common process in normal human small intestine	151
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer	150
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders	150
A generalized linear mixed model association tool for biobank-scale data	148
RNA polymerase II dynamics shape enhancer–promoter interactions	146
Recent ultra-rare inherited variants implicate new autism candidate risk genes	143
H3K27me3 conditions chemotolerance in triple-negative breast cancer	143
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases	142
HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors	141
Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment	139

Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice	138
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function	137
Redefining teleost phylogeny	137
Mutation rates across species	136
Bottleneck size and selection level reproducibly impact evolution of antibiotic resistance	134
Somatic recombination of repetitive elements	134
An eRNA transcription checkpoint for diverse signal-dependent enhancer activation programs	134
Equity, ethics and the promise of partnership in genomic medicine	132
Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries	131
Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition	131
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements	131
Sarcoma predisposition	130
Sox2 expression can be regulated across boundaries generated by CTCF–cohesin loops	129
Genetic and biological insights into spontaneous coronary artery dissection	128
Epigenetic scars of Brca1 loss point toward breast cancer cell of origin	126
Defining and pursuing diversity in human genetic studies	126
The genetic origins of multiple sclerosis	126
Polygenic basis for seedless grapes	124
Defining genome access of transcription factors	123
Indirect paths from genetics to education	122
Planting the milestones of human genetics in Senegal	120
New genes helped acorn barnacles adapt to a sessile lifestyle	120
Improving estimates of loss-of-function constraint for short genes	118
Mathematical modeling of neuroblastoma associates evolutionary patterns with outcomes	117
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations	115
Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases	115
Coordinated function of paired NLRs confers Yr84-mediated stripe rust resistance in wheat	115
Federated analysis of autosomal recessive coding variants in 29,745 developmental disorder patients from diverse populations	115
Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish	114
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype	113
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification	113
A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription	112
Disease prediction with multi-omics and biomarkers empowers case–control genetic discoveries in the UK Biobank	110
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture	110
Consensus prediction of cell type labels in single-cell data with popV	110
A complete telomere-to-telomere assembly of the maize genome	110