OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Genetics is 113. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
Toward advances in retinoblastoma genetics in Kenya	1797
Epigenetic memory in 3D	1138
Deciphering the evolutionary dynamics of extrachromosomal DNA in human cancer	677
Mapping dog behavior	549
Role of gene–gene loops in fine-tuning cross-regulation	520
Temperature-induced RNA recoding in octopus	520
Machine learning drives genetic discovery for binge eating disorder	501
Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores	480
DNA polymerase ε produces elevated C-to-T mutations at methylated CpG dinucleotides	475
GeneMAP enables discovery of metabolic gene function	467
Cicer super-pangenome provides insights into species evolution and agronomic trait loci for crop improvement in chickpea	435
Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize	433
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease	399
Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness	372
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption	370
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals	323
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome	316
In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization	303
A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation	296
Genome-wide RNA polymerase stalling shapes the transcriptome during aging	295
Reactivation of embryonic genetic programs in tissue regeneration and disease	292
Predicting obesity from childhood	291
Problems with dystopian representations in genetic futurism	288
Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas	275
Complete genomes of six ape species	274

An atlas of genetic determinants of forearm fracture	272
Mitochondrial DNA mosaicism in normal human somatic cells	272
Cracking the histone code for prostate cancer therapy	268
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes	256
The Solve-RD Solvathons as a pan-European interdisciplinary collaboration to diagnose patients with rare disease	237
Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells	231
Understanding liver repair through space and time	231
The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes	225
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases	215
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways	213
Rare coding variant analysis for human diseases across biobanks and ancestries	213
Shared genetics of substance use disorders	212
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development	212
A biology-aware mutation rate model for human germline	206
Genes influence complex traits through environments that vary between geographic regions	200
Genetic and non-genetic HLA disruption is widespread in lung and breast tumors	195
Finding cancer mutagens using signature analysis	192
Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome	190
Somatic mutations in the stomach	190
Identification of two intrinsic epithelial subtypes of colorectal cancer	190
Author Correction: Pangenome graphs and their applications in biodiversity genomics	185
The Federated European Genome–Phenome Archive as a global network for sharing human genomics data	183
Safeguard repressor locks hepatocyte identity and blocks liver cancer	183
When RNA methylation meets DNA methylation	179
APOBEC mutagenesis is a common process in normal human small intestine	179
Establishing African genomics and bioinformatics programs through annual regional workshops	179
An alternative model for maternal mtDNA inheritance	178
Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon	176
Histone gene editing probes functions of H3K27 modifications in mammals	171
Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice	167
Author Correction: The NAT1–bHLH110–CER1/CER1L module regulates heat stress tolerance in rice	167
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas	165
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function	162
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen	162
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction	162
Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks	162
Recycling enhancers	161
Interpreting cis-regulatory interactions from large-scale deep neural networks	160
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription	159
Finding causal genes underlying risk for coronary artery disease	157
Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk	154
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits	154
HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors	154
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity	152
Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice	152
Bayesian estimation of gene constraint from an evolutionary model with gene features	150
Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors	147
Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment	146
RNA polymerase II dynamics shape enhancer–promoter interactions	145
Increasing diversity in genomics requires investment in equitable partnerships and capacity building	144

A generalized linear mixed model association tool for biobank-scale data	144
H3K27me3 conditions chemotolerance in triple-negative breast cancer	143
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders	143
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases	142
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer	142
Equity, ethics and the promise of partnership in genomic medicine	141
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns	141
An eRNA transcription checkpoint for diverse signal-dependent enhancer activation programs	138
Mutation rates across species	137
Redefining teleost phylogeny	137
Somatic recombination of repetitive elements	135
Sarcoma predisposition	131
SBRR1-R variant regulates sheath blight resistance in rice	131
Genetic and biological insights into spontaneous coronary artery dissection	130
Why genomic diversity should not be framed by census alone	130
Sox2 expression can be regulated across boundaries generated by CTCF–cohesin loops	129
The genetic origins of multiple sclerosis	129
Improving estimates of loss-of-function constraint for short genes	126
New genes helped acorn barnacles adapt to a sessile lifestyle	126
Federated analysis of autosomal recessive coding variants in 29,745 developmental disorder patients from diverse populations	126
Mathematical modeling of neuroblastoma associates evolutionary patterns with outcomes	125
Planting the milestones of human genetics in Senegal	124
Indirect paths from genetics to education	123
Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish	122
Schizophrenia risk conferred by rare protein-truncating variants is conserved across diverse human populations	122
A pangenome of maize provides genetic insights into drought resistance	122
Epigenetic scars of Brca1 loss point toward breast cancer cell of origin	121
Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases	121
Consensus prediction of cell type labels in single-cell data with popV	121
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification	118
Defining genome access of transcription factors	118
Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition	118
Polygenic basis for seedless grapes	118
Nucleotide dependency analysis of genomic language models detects functional elements	117
Genetic and epigenetic screens in primary human T cells link candidate causal autoimmune variants to T cell networks	117
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells	115
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq	114
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype	113
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements	113