OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Genetics is 111. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Toward advances in retinoblastoma genetics in Kenya	927
Epigenetic memory in 3D	727
Deciphering the evolutionary dynamics of extrachromosomal DNA in human cancer	715
Mapping dog behavior	590
Role of gene–gene loops in fine-tuning cross-regulation	484
Machine learning drives genetic discovery for binge eating disorder	444
Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores	437
DNA polymerase ε produces elevated C-to-T mutations at methylated CpG dinucleotides	392
GeneMAP enables discovery of metabolic gene function	374
Predicting obesity from childhood	349
Cracking the histone code for prostate cancer therapy	337
Criteria for prioritizing trait-relevant genes	302
Complete genomes of six ape species	295
Defining the transcriptional landscape in the classical subtype of pancreatic cancer	295
Chromatin loop proteomics finds a non-catalytic function for a histone demethylase	278
Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas	273
Tumor DNA methylation subtypes predict immunotherapy outcomes in pleural mesothelioma patients in the NIBIT-EPI-MESO study	271
Somatic mutations link focal onset to widespread neurodegeneration in ALS and FTD	259
A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation	256
Author Correction: Single-cell atlas of the transcriptome and chromatin accessibility in the human retina	254
Understanding liver repair through space and time	248
JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation	246
Genome-wide fine-mapping improves identification of causal variants	244
Genomic landscape of the human vaginal microbiome is linked to host genetics and population of origin	243
Advances and challenges of splicing prediction with AI	240

Insights from three decades of BRCA1/2 modeling in mice	230
Reactivation of embryonic genetic programs in tissue regeneration and disease	229
The Solve-RD Solvathons as a pan-European interdisciplinary collaboration to diagnose patients with rare disease	228
In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization	226
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes	223
An atlas of genetic determinants of forearm fracture	223
Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness	221
The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes	220
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption	218
Mitochondrial DNA mosaicism in normal human somatic cells	203
Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease	202
Problems with dystopian representations in genetic futurism	198
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases	198
Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize	198
Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells	196
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development	196
Temperature-induced RNA recoding in octopus	195
Genome-wide RNA polymerase stalling shapes the transcriptome during aging	195
Cicer super-pangenome provides insights into species evolution and agronomic trait loci for crop improvement in chickpea	190
Rare coding variant analysis for human diseases across biobanks and ancestries	190
Shared genetics of substance use disorders	183
A biology-aware mutation rate model for human germline	182
Genes influence complex traits through environments that vary between geographic regions	181
Finding cancer mutagens using signature analysis	180
Genetic and non-genetic HLA disruption is widespread in lung and breast tumors	180
Somatic mutations in the stomach	180
High-content genetic screens identify RNA-based mechanisms to target immune evasion	179
Single-cell expression QTL analyses of the human cerebellum reveal vulnerability of oligodendrocytes in essential tremor	177
Publisher Correction: A genetic module boosts grain yield and nitrogen use efficiency by improving nitrate transport in maize	177
Genetic associations with educational fields	175
Recycling enhancers	173
Finding causal genes underlying risk for coronary artery disease	170
Publisher Correction: APOBEC3 mutagenesis drives therapy resistance in breast cancer	169
The emergence of metastasis in colorectal cancer	169
Author Correction: Pangenome graphs and their applications in biodiversity genomics	168
Author Correction: The NAT1–bHLH110–CER1/CER1L module regulates heat stress tolerance in rice	165
Exploring the mammalian metabolome with DeepMet	163
Safeguard repressor locks hepatocyte identity and blocks liver cancer	162
The Federated European Genome–Phenome Archive as a global network for sharing human genomics data	162
Stromal immune cell signatures predict risk of progression in meningioma	162
An alternative model for maternal mtDNA inheritance	157
Histone acetylation-dependent clustering of BRD2 instructs transcription dynamics	155
APOBEC mutagenesis is a common process in normal human small intestine	154
Establishing African genomics and bioinformatics programs through annual regional workshops	153
When RNA methylation meets DNA methylation	152
Epigenetically driven and early immune evasion in colorectal cancer evolution	151
Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice	149
Lineage tracing from cellular heritage to disease destiny	149
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription	145
Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice	144

Bayesian estimation of gene constraint from an evolutionary model with gene features	143
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction	141
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer	140
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns	137
Interpreting cis-regulatory interactions from large-scale deep neural networks	136
Patterns of hypermutation shape tumorigenesis and immunotherapy response in mismatch-repair-deficient glioma	134
Designing synthetic regulatory elements using the generative AI framework DNA-Diffusion	134
Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks	132
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen	132
Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors	130
Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment	129
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases	128
Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk	127
Proteome-wide model for human disease genetics	126
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits	126
RNA polymerase II dynamics shape enhancer–promoter interactions	124
Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon	123
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity	122
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas	122
Equity, ethics and the promise of partnership in genomic medicine	121
Redefining teleost phylogeny	119
Somatic recombination of repetitive elements	119
Sarcoma predisposition	117
SBRR1-R variant regulates sheath blight resistance in rice	117
Genetic and biological insights into spontaneous coronary artery dissection	115
Sox2 expression can be regulated across boundaries generated by CTCF–cohesin loops	114
Single-cell multiomics analysis reveals dynamic clonal evolution and targetable phenotypes in acute myeloid leukemia with complex karyotype	113
Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition	113
The PRECISE European initiative for cancer-vulnerability mapping and prediction	113
Toward a framework for measuring the impact of ELSI research	112
Dissecting the impact of transcription factor dose on cell reprogramming heterogeneity using scTF-seq	112
A biobank-scale test of marginal epistasis reveals genome-wide signals of polygenic interaction effects	112
Defining and pursuing diversity in human genetic studies	112
A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription	112
Deep learning-based phenotype imputation on population-scale biobank data increases genetic discoveries	112
GWAS meta-analysis of over 29,000 people with epilepsy identifies 26 risk loci and subtype-specific genetic architecture	111
Planting the milestones of human genetics in Senegal	111
Improving estimates of loss-of-function constraint for short genes	111