OOIR: Observatory of International Research

Papers

(The H4-Index of Nature Genetics is 113. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-10-01 to 2025-10-01.)

Article	Citations
Deciphering the evolutionary dynamics of extrachromosomal DNA in human cancer	1725
Mapping dog behavior	1086
Epigenetic memory in 3D	642
Temperature-induced RNA recoding in octopus	535
Toward advances in retinoblastoma genetics in Kenya	495
DNA polymerase ε produces elevated C-to-T mutations at methylated CpG dinucleotides	495
Role of gene–gene loops in fine-tuning cross-regulation	478
Machine learning drives genetic discovery for binge eating disorder	463
Identifying individuals at extreme risk of venous thromboembolism using polygenic risk scores	459
GeneMAP enables discovery of metabolic gene function	454
The BAF chromatin remodeler synergizes with RNA polymerase II and transcription factors to evict nucleosomes	441
Genetic variation at transcription factor binding sites largely explains phenotypic heritability in maize	420
The Solve-RD Solvathons as a pan-European interdisciplinary collaboration to diagnose patients with rare disease	419
Mitochondrial DNA mosaicism in normal human somatic cells	380
Genome-wide RNA polymerase stalling shapes the transcriptome during aging	359
Understanding liver repair through space and time	357
Complete genomes of six ape species	309
Predicting obesity from childhood	301
Problems with dystopian representations in genetic futurism	289
Reactivation of embryonic genetic programs in tissue regeneration and disease	288
Dominant variants in major spliceosome U4 and U5 small nuclear RNA genes cause neurodevelopmental disorders through splicing disruption	286
In vitro reconstitution of chromatin domains shows a role for nucleosome positioning in 3D genome organization	283
Telomere-to-telomere sheep genome assembly identifies variants associated with wool fineness	282
A chromatin-regulated biphasic circuit coordinates IL-1β-mediated inflammation	280
Dynamics of DNA hydroxymethylation and methylation during mouse embryonic and germline development	274

Functional dissection of human cardiac enhancers and noncoding de novo variants in congenital heart disease	269
Renal plasticity revealed through reversal of polycystic kidney disease in mice	265
Genome-wide association meta-analysis of childhood ADHD symptoms and diagnosis identifies new loci and potential effector genes	263
Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome	263
Integrated single-cell chromatin and transcriptomic analyses of human scalp identify gene-regulatory programs and critical cell types for hair and skin diseases	258
Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways	247
Cicer super-pangenome provides insights into species evolution and agronomic trait loci for crop improvement in chickpea	231
Mutational signatures in esophageal squamous cell carcinoma from eight countries with varying incidence	227
Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals	219
An atlas of genetic determinants of forearm fracture	216
Rare coding variant analysis for human diseases across biobanks and ancestries	208
Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells	208
Shared genetics of substance use disorders	205
A biology-aware mutation rate model for human germline	205
Genes influence complex traits through environments that vary between geographic regions	204
Somatic mutations in the stomach	200
Identification of two intrinsic epithelial subtypes of colorectal cancer	192
Author Correction: The NAT1–bHLH110–CER1/CER1L module regulates heat stress tolerance in rice	187
The Federated European Genome–Phenome Archive as a global network for sharing human genomics data	187
Epigenomic contributions to tumor cell heterogeneity and plasticity	186
Finding causal genes underlying risk for coronary artery disease	186
Author Correction: EMPReSS: standardized phenotype screens for functional annotation of the mouse genome	184
Genetic and non-genetic HLA disruption is widespread in lung and breast tumors	178
Finding cancer mutagens using signature analysis	177
Natural variation in SBRR1 shows high potential for sheath blight resistance breeding in rice	174
Systematic prioritization of functional variants and effector genes underlying colorectal cancer risk	173
Author Correction: Pangenome graphs and their applications in biodiversity genomics	173
Genome-wide association analyses of breast cancer in women of African ancestry identify new susceptibility loci and improve risk prediction	173
Safeguard repressor locks hepatocyte identity and blocks liver cancer	172
RNA polymerase II dynamics shape enhancer–promoter interactions	170
When RNA methylation meets DNA methylation	167
Histone gene editing probes functions of H3K27 modifications in mammals	161
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen	161
Human subcutaneous and visceral adipocyte atlases uncover classical and nonclassical adipocytes and depot-specific patterns	160
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits	157
Establishing African genomics and bioinformatics programs through annual regional workshops	157
An alternative model for maternal mtDNA inheritance	157
Solanum americanum genome-assisted discovery of immune receptors that detect potato late blight pathogen effectors	157
Meta-analysis of genome-wide associations and polygenic risk prediction for atrial fibrillation in more than 180,000 cases	154
Pushing the boundaries of rare disease diagnostics with the help of the first Undiagnosed Hackathon	154
Interpreting cis-regulatory interactions from large-scale deep neural networks	153
Suppressing a phosphohydrolase of cytokinin nucleotide enhances grain yield in rice	151
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function	149
HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription	149
Increasing diversity in genomics requires investment in equitable partnerships and capacity building	149
Bayesian estimation of gene constraint from an evolutionary model with gene features	147
APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer	145
Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders	144
K27M in canonical and noncanonical H3 variants occurs in distinct oligodendroglial cell lineages in brain midline gliomas	142
Synthetic surrogates improve power for genome-wide association studies of partially missing phenotypes in population biobanks	140

A generalized linear mixed model association tool for biobank-scale data	140
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity	140
HLA autoimmune risk alleles restrict the hypervariable region of T cell receptors	139
APOBEC mutagenesis is a common process in normal human small intestine	139
H3K27me3 conditions chemotolerance in triple-negative breast cancer	138
Redefining teleost phylogeny	137
Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment	137
Mutation rates across species	136
An eRNA transcription checkpoint for diverse signal-dependent enhancer activation programs	135
Somatic recombination of repetitive elements	135
Equity, ethics and the promise of partnership in genomic medicine	133
Consensus prediction of cell type labels in single-cell data with popV	133
Defining and pursuing diversity in human genetic studies	132
Dissecting tumor transcriptional heterogeneity from single-cell RNA-seq data by generalized binary covariance decomposition	132
SBRR1-R variant regulates sheath blight resistance in rice	129
Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas	128
Why genomic diversity should not be framed by census alone	126
A multi-tissue single-cell expression atlas in cattle	126
Sarcoma predisposition	126
Sox2 expression can be regulated across boundaries generated by CTCF–cohesin loops	125
Genetic and biological insights into spontaneous coronary artery dissection	124
Coordinated function of paired NLRs confers Yr84-mediated stripe rust resistance in wheat	122
The genetic origins of multiple sclerosis	122
Federated analysis of autosomal recessive coding variants in 29,745 developmental disorder patients from diverse populations	120
New genes helped acorn barnacles adapt to a sessile lifestyle	120
Epigenetic scars of Brca1 loss point toward breast cancer cell of origin	119
A mutation rate model at the basepair resolution identifies the mutagenic effect of polymerase III transcription	119
Defining genome access of transcription factors	117
Polygenic basis for seedless grapes	117
Indirect paths from genetics to education	116
Improving estimates of loss-of-function constraint for short genes	115
Planting the milestones of human genetics in Senegal	115
Mathematical modeling of neuroblastoma associates evolutionary patterns with outcomes	114
Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification	113
ChIP-DIP maps binding of hundreds of proteins to DNA simultaneously and identifies diverse gene regulatory elements	113
Integrating population genetics, stem cell biology and cellular genomics to study complex human diseases	113
Adipose tissue eQTL meta-analysis highlights the contribution of allelic heterogeneity to gene expression regulation and cardiometabolic traits	113
Genome-wide analysis of cis-regulatory changes underlying metabolic adaptation of cavefish	113