OOIR: Observatory of International Research

Papers

(The TQCC of Clinical and Experimental Hypertension is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
Correlation between elevated maternal serum alpha-fetoprotein and ischemic placental disease: a retrospective cohort study	132
Ghrelin improves endothelial function and reduces blood pressure in Ang II-induced hypertensive mice: Role of AMPK	126
Xinshuaining preparation protects H9c2 cells from H ₂ O ₂ -induced oxidative damage through the PI3K/Akt/Nrf-2 signaling pathway	85
Identification of endoplasmic reticulum stress-associated signatures of human pulmonary arterial hypertension: A bioinformatic analysis	45
New insights into clinical strategies for acute coronary syndrome based on biomarker-driven multiomics research	37
What is the prevalence of chronic kidney disease among hypertensive non-diabetic Egyptian patients attending primary healthcare?	34
Calcitriol reverses age-related hypertension via downregulating renal AP1/AT ₁ R pathway through regulating mitochondrial function	31
Establishment of a lupus-prone mouse model of pulmonary arterial hypertension with intermittent hypoxia: functional, biochemical and histological verifications	28
Ketogenic diet inhibits neointimal hyperplasia by suppressing oxidative stress and inflammation	28
Blood pressure variability: From predictive marker to intervention target-breaking the vicious cycle of hypertensive target organ damage	24
Angiotensin II-induced vascular endothelial cells ferroptosis via P53-ALOX12 signal axis	24
FUNDC2 contributes to hypertensive vascular remodeling by regulating mitochondrial dynamics and ferroptosis in perivascular adipose tissue	22
Gestational diabetes causes hyperactivity of the sympathetic nervous system and hypertension in adult mice offspring	22
Thymoquinone improved redox homeostasis in the heart and aorta of hypothyroid rats	22
The causal relationship between aspartate aminotransferase and hypertension: A bidirectional Mendelian randomization study	21
High-salt diets provoke phosphorus absorption from the small intestine in mice	19
Soyasaponin I alleviates hypertensive intracerebral hemorrhage by inhibiting the renin–angiotensin–aldosterone system	19
FGFR2 modulates the Akt/Nrf2/ARE signaling pathway to improve angiotensin II-induced hypertension-related endothelial dysfunction	18
Mechanistic study of the association between microRNA-126 and hypertension in obstructive sleep apnea-hypopnea syndrome	18
The correlation between nuts and algae-less diet and children’s blood pressure: from a cross-sectional study in Chongqing	18
Factors influencing blood pressure variability in postmenopausal women: evidence from the China Health and Nutrition Survey	17
Causal relationship between gut microbiota, plasma metabolites, inflammatory cytokines and abdominal aortic aneurysm: a Mendelian randomization study	16
Research hotspots and trends regarding microRNAs in hypertension: a bibliometric analysis	16
Association between renal surface nodularity and increased adverse vascular event risk in patients with arterial hypertension	15
Circulating circular RNAs as biomarkers for the diagnosis of essential hypertension with carotid plaque	15

The causal relationship between circulating metabolites and gestational hypertension, pre-eclampsia, eclampsia: A bidirectional two-sample Mendelian randomization study	15
FGF21 attenuates salt-sensitive hypertension via regulating HNF4α/ACE2 axis in the hypothalamic paraventricular nucleus of mice	14
Association analysis of MTHFR (rs1801133 and rs1801131) and MTRR (rs1801394) gene polymorphisms towards the development of hypertension in the Bai population from Yunnan, China	14
Disruption of the caspase-1/IL-1β axis alleviates myocardial Ischemia/Reperfusion injury via improvement of mitochondrial homeostasis and reduction of Pyroptosis	14
Different cardiovascular responses to exercise training in hypertensive women receiving β-blockers or angiotensin receptor blockers: A pilot study	14
Dexmedetomidine attenuates pneumocyte apoptosis and inflammation induced by aortic ischemia-reperfusion injury	12
Chinese herbal medicine formula combined with calcium antagonist in the treatment of hypertension: a systematic review and meta-analysis	12
Effect of prior beta-blocker use on in-hospital atrial fibrillation development in patients with ST-elevation myocardial infarction	11
The positive association between the atherogenic index of plasma and the risk of new-onset hypertension: a nationwide cohort study in China	11
Relationship between inflammatory cells level and longer duration of hypertension in Chinese community residents	11
Effects of YM155 on the proliferation and apoptosis of pulmonary artery smooth muscle cells in a rat model of high pulmonary blood flow-induced pulmonary arterial hypertension	10
A retrospective analysis of incidence and severity of COVID-19 among hypertensive patients: the other side	10
Correlation between pulmonary vascular performance and hemodynamics in patients with pulmonary arterial hypertension	10
Antihypertensive effect and the underlying mechanisms of action of phytolaccagenin in rat models	10
Sildenafil prevents right ventricular hypertrophy and improves heart rate variability in rats with pulmonary hypertension secondary to experimental diabetes	10
Rebound sign: a case report and review of literature	9
TIP60 mediates stress-induced hypertension via promoting glutamate ^dmPFC- ^to- ^vCA1 release	9
Relationship between ambulatory arterial stiffness index and the severity of angiographic atherosclerosis in patients with H-type hypertension and coronary artery disease	9
Genetic causal assessment between major depression and hypertension: A two-sample bidirectional Mendelian randomization study	9
Knowledge, attitude and preparedness of healthcare students toward basic life support at King Khalid University, Abha, Kingdom of Saudi Arabia	9
Iron status mediates the causal effects of high-altitude adaptation signals in the HIF–PHD axis on pulmonary vascular and right-heart outcomes	9
The relationship between mean platelet volume and resistant hypertension	9
Central Venous Catheter as a Novel Approach to Postoperative Thrombolysis in Patients with Acute Iliofemoral Deep Venous Thrombosis	8
Fatty liver is a sensitive early warning for hypertension and its complication in the Chinese population	8
The effect of calcium channel blocker (CCB) treatment on retinal and choroidal vessels in a group of hypertensive patients	8
Correction	8
Efficacy and safety of intensive blood pressure control in patients over 60 years: A systematic review and meta-analysis	8
Association between the triglyceride–glucose index and carotid artery plaque burden in patients with primary hypertension: A cross-sectional study	8
Age, creatinine, and ejection fraction (ACEF) score as predictive values for late non-valvular atrial fibrillation recurrence after radiofrequency ablation	8
Exploration and validation of signature genes and immune associations in septic cardiomyopathy	8
The role of immune mechanisms in hypertension and advances in immunomodulatory research	8
Influence of blood pressure variations during hemodialysis on the prognosis of dialysis patients	7
GSDMD-mediated pyroptosis promotes cardiac remodeling in pressure overload	7
MicroRNA153 induces apoptosis by targeting NFATc3 to improve vascular remodeling in pulmonary hypertension	7
RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling	7
Clinical study on effect of wrist-ankle acupuncture on incidence of hypertension after intubation during induction of general anesthesia	7
Association of triglycerides to high density lipoprotein cholesterol ratio with hypertension in Chinese adults: a cross-sectional study	7
CircUsp9x/miR-599/stim1 axis regulates proliferation and migration in vascular smooth muscle cells induced by oxidized-low density lipoprotein	7
Expression of TGF-β/Smad pathway-related indices in patients with isolated iliac artery aneurysms complicated with iliac arteriovenous fistula and their relationship with prognosis	7
Interdisciplinary collaborative care model combined with family empowerment in patients with comorbid hypertension and diabetes: A study on blood pressure/glucose control and psychosocial adaptation b	7
The proliferation/migration ability mediated by CD151/PI3K/AKT pathway determines the therapeutic effect of hUC-MSCs transplantation on rheumatoid arthritis	7
Transcatheter hybrid closure of a large muscular ventricular septal defect with severe pulmonary hypertension using a duct occluder	7
Ginsenoside Rh2 mitigates myocardial damage in acute myocardial infarction by regulating pyroptosis of cardiomyocytes	7
Association between hypertension and prognosis of patients with COVID-19: A systematic review and meta-analysis	7
Canagliflozin ameliorates hypobaric hypoxia-induced pulmonary arterial hypertension by inhibiting pulmonary arterial smooth muscle cell proliferation	7