OOIR: Observatory of International Research

Papers

(The TQCC of Wound Repair and Regeneration is 7. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-05-01 to 2024-05-01.)

Article	Citations
Chronic wounds: Treatment consensus	98
Diabetic wound healing: The impact of diabetes on myofibroblast activity and its potential therapeutic treatments	50
Fibroblast‐like synoviocytes: Role in synovial fibrosis associated with osteoarthritis	47
Myofibroblast progeny in wound biology and wound healing studies	38
The zone model: A conceptual model for understanding the microenvironment of chronic wound infection	32
Vimentin regulates the assembly and function of matrix adhesions	29
Monocyte and macrophage derived myofibroblasts: Is it fate? A review of the current evidence	29
Pullulan‐Collagen hydrogel wound dressing promotes dermal remodelling and wound healing compared to commercially available collagen dressings	27
Stem cell‐mediated angiogenesis in skin tissue engineering and wound healing	27
Prophylactic dressings in the prevention of pressure ulcer related to the use of personal protective equipment by health professionals facing the COVID‐19 pandemic: A randomized clinical trial	24
Antibiofilm activity of chitosan/epsilon‐poly‐L‐lysine hydrogels in a porcine ex vivo skin wound polymicrobial biofilm model	22
Granulation tissue myofibroblasts during normal and pathological skin healing: The interaction between their secretome and the microenvironment	22
What is the “normal” wound bed temperature? A scoping review and new hypothesis	22
Myofibroblast fate plasticity in tissue repair and fibrosis: Deactivation, apoptosis, senescence and reprogramming	21
Evidence‐based therapy in hypertrophic scars: An update of a systematic review	20
A novel chronic wound biofilm model sustaining coexistence of Pseudomonas aeruginosa and Staphylococcus aureus suitable for testing of antibiofilm effect of antimic	19
Annexin A1‐derived peptide Ac2‐26 facilitates wound healing in diabetic mice	19
Is there an association between anemia and diabetic foot ulcers? A systematic review and meta‐analysis	18
Evaluation of LL‐37 in healing of hard‐to‐heal venous leg ulcers: A multicentric prospective randomized placebo‐controlled clinical trial	18
A story of fibers and stress: Matrix‐embedded signals for fibroblast activation in the skin	18
Negative‐pressure wound therapy for III/IV pressure injuries: A meta‐analysis	17
Analyzing factors affecting quality of life in patients hospitalized with chronic wound	17
LncRNA HOTAIR modulates chondrocyte apoptosis and inflammation in osteoarthritis via regulating miR‐1277‐5p/SGTB axis	17
Epidemiological characteristics and clinical analyses of chronic cutaneous wounds of inpatients in China: Prevention and control	17
A review of epigenetic regulation in wound healing: Implications for the future of wound care	16

Optical imaging of collagen fiber damage to assess thermally injured human skin	16
Potential markers of healing from near infrared spectroscopy imaging of venous leg ulcer. A randomized controlled clinical trial comparing conventional with hyperbaric oxygen treatment	15
Galectin‐1 production is elevated in hypertrophic scar	15
Assessment of a smartphone‐based application for diabetic foot ulcer measurement	15
Development of a PHMB hydrogel‐modified wound scaffold dressing with antibacterial activity	14
Protective effect of dimethyl fumarate for the development of pressure ulcers after cutaneous ischemia‐reperfusion injury	14
The hard problem: Mechanotransduction perpetuates the myofibroblast phenotype in scleroderma fibrosis	14
Novel factors that activate and deactivate cardiac fibroblasts: A new perspective for treatment of cardiac fibrosis	14
Analysis of HOX gene expression and the effects of HOXA9 overexpression in fibroblasts derived from keloid lesions and normal skin	14
Anti‐inflammatory effects of haptoglobin on LPS‐stimulated macrophages: Role of HMGB1 signaling and implications in chronic wound healing	14
Evidence supporting wound care end points relevant to clinical practice and patients' lives. Part 3: The Patient Survey	14
The role of negative pressure wound therapy (NPWT) on the treatment of pyoderma gangrenosum: A systematic review and personal experience	14
Bacterial chatter in chronic wound infections	14
A systematic review evaluating the influence of incisional Negative Pressure Wound Therapy on scarring	14
Effects of physical activity as an adjunct treatment on healing outcomes and recurrence of venous leg ulcers: A scoping review	13
Development and psychometric evaluation of the U.S. English Wound‐QoL questionnaire to assess health‐related quality of life in people with chronic wounds	13
Growth factors for treating chronic venous leg ulcers: A systematic review and meta‐analysis	13
Protease activity as a prognostic factor for wound healing in complex wounds	13
HCN2 channel‐induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling	13
Photobiomodulation promotes hair regeneration in injured skin by enhancing migration and exosome secretion of dermal papilla cells	13
Pyoderma gangrenosum study pilot registry: The first step to a better understanding	13
Quality‐of‐life of people with keloids and its correlation with clinical severity and demographic profiles	12
Efficacy of alginate‐and chitosan‐based scaffolds on the healing of diabetic skin wounds in animal experimental models and cell studies: A systematic review	12
Assessing the quality of life of people with chronic wounds by using the cross‐culturally valid and revised Wound‐QoL questionnaire	12
Food and Drug Administration perspective: Advancing product development for non‐healing chronic wounds	12
APACHE scoring system and pressure injury risk for intensive care patients: A systematic review and meta‐analysis	12
Proximal digit tip amputation initiates simultaneous blastema and transient fibrosis formation and results in partial regeneration	12
Liposome‐encapsulated statins reduce hypertrophic scarring through topical application	12
Photoacoustic monitoring of angiogenesis predicts response to therapy in healing wounds	12
Rapid detection of biofilm with modified alcian blue staining: In‐vitro protocol improvement and validation with clinical cases	12
Gene therapy in wound healing using nanotechnology	12
Poly(lactide‐co‐ε‐caprolactone) scaffold promotes equivalent tissue integration and supports skin grafts compared to a predicate collagen scaffold	11
Keloid tissue analysis discredits a role for myofibroblasts in disease pathogenesis	11
Bacteria and bioburden and healing in complex wounds: A prognostic systematic review	11
Fat graft for reducing pain in chronic wounds	11
Decreased expression of miR‐24 in peripheral plasma of type 2 diabetes mellitus patients associated with diabetic foot ulcer	11
Effective enzymatic debridement of burn wounds depends on the denaturation status of collagen	11
Polysaccharide‐rich hydrogel formulation combined with photobiomodulation repairs UV‐induced photodamage in mice skin	11
Effects of platelet‐rich plasma on the healing of sternal wounds: A meta‐analysis	10
Current applications of platelet gels in wound healing—A review	10
Effectiveness of a synthetic human recombinant epidermal growth factor in diabetic patients wound healing: Pilot, double‐blind, randomized clinical con	10
LncRNA MIR503HG promotes hypertrophic scar progression via miR‐143‐3p‐mediated Smad3 expression	10
Bromelain‐based enzymatic debridement of chronic wounds: Results of a multicentre randomized controlled trial	10
The modulation of the burn wound environment by negative pressure wound therapy: Insights from the proteome	10
To compare the effect of sea buckthorn and silver sulfadiazine dressing on period of wound healing in patients with second‐degree burns: A randomized triple‐blind clinical trial	10
Incidence of and risk factors for self‐load‐related and medical device‐related pressure injuries in critically ill patients: A prospective observational cohort study	9
Recent advances in the induced pluripotent stem cell‐based skin regeneration	9
Evaluation of contraction of the split‐thickness skin graft using three dermal matrices in the treatment of burn contractures: A randomised clinical trial	9
Further evidence that wound size and duration are strong prognostic markers of diabetic foot ulcer healing	9
Integrin α4β1 is required for IL‐1α‐ and Nrf2‐dependent, Cox‐2 induction in fibroblasts, supporting a mechanism that suppresses α‐SMA expression	9

The pig as a model system for investigating the recruitment and contribution of myofibroblasts in skin healing	9
Dissolved oxygen technologies as a novel strategy for non‐healing wounds: A critical review	9
Matrix metalloproteinase (MMP)‐1 and MMP‐2, but not COX‐2 serve as additional predictors for chronic venous ulcer healing	9
To regenerate or not to regenerate: Vertebrate model organisms of regeneration‐competency and ‐incompetency	9
Efficacy of allogeneic cord blood platelet gel on wounds of dystrophic epidermolysis bullosa patients after pseudosyndactyly surgery	9
Silk proteins in reconstructive surgery: Do they possess an inherent antibacterial activity? A systematic review	8
Comparing the effects of three different multilayer dressings for pressure ulcer prevention on sacral skin after prolonged loading: An exploratory crossover trial	8
The role of bacterial extracellular vesicles in chronic wound infections: Current knowledge and future challenges	8
Evolution of ischemia and neovascularization in a murine model of full thickness human wound healing	8
Association of vaping with decreased vascular endothelial growth factor expression and decreased microvessel density in cutaneous wound healing tissue in rats	8
Aerobic glycolysis is important for zebrafish larval wound closure and tail regeneration	8
Scar quality in children with burns 5–7 years after injury: A cross‐sectional multicentre study	8
The surgical approach to Pyoderma gangrenosum: A retrospective monocenter study	8
Using systems biology approaches to identify signalling pathways activated during chronic wound initiation	8
Hyperbaric oxygen therapy for nonhealing wounds: Treatment results of a single center	8
Pulsed dye laser versus ablative fractional CO₂ laser in treatment of old hypertrophic scars: Clinicopathological study	8
Autologous thrombin preparations: Biocompatibility and growth factor release	7
Engineered microenvironment for the study of myofibroblast mechanobiology	7
Pigment epithelium‐derived factor attenuates angiogenesis and collagen deposition in hypertrophic scars	7
The wound healing effect of local leukocyte platelet‐rich plasma after total hip arthroplasty: A randomized controlled trial	7
Reactive oxygen species during heart regeneration in zebrafish: Lessons for future clinical therapies	7
Valsartan nano‐filaments alter mitochondrial energetics and promote faster healing in diabetic rat wounds	7
Comparison of comparable scald and contact burns in a porcine model: A preliminary report	7
Animal models for the study of acute cutaneous wound healing	7
Bacterial protease activity as a biomarker to assess the risk of non‐healing in chronic wounds: Results from a multicentre prospective cohort clinical trial	7
Efficacy of low‐level light therapy for improving healing of diabetic foot ulcers: A systematic review and meta‐analysis of randomized controlled trials	7