OOIR: Observatory of International Research

Papers

(The TQCC of In Vitro Cellular & Developmental Biology-Animal is 3. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
PRRX1 upregulates PD-L1 in human mesenchymal stem cells	19
Cytosine-phosphate-guanine oligodeoxynucleotides regulate the cell cycle, apoptosis, and steroidogenesis of mouse ovarian granulosa cells by targeting inhibin alpha (1 ~ 32) fragments	16
DHA attenuates cartilage degeneration by mediating apoptosis and autophagy in human chondrocytes and rat models of osteoarthritis	15
The origins of human pluripotent stem cells: the road from a cancer to regenerative medicine	14
Dexmedetomidine preserves neuronal function by promoting mitochondrial biogenesis through the AMPK/PGC-1α pathway	14
Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway	14
Mechanical regulation of N2A neural cell behavior by microtissue densification	13
Calycosin prevents IL-1β-induced articular chondrocyte damage in osteoarthritis through regulating the PI3K/AKT/FoxO1 pathway	13
Ghrelin inhibits NLRP3 inflammasome activation by upregulating autophagy to improve Alzheimer’s disease	13
A cell line derived from the black soldier fly, Hermetia illucens (Diptera: Stratiomyidae)	12
Bringing cell biology into classroom: tips to culture and observe skeletal muscle cells in high school and college	12
BMSC-derived exosomes regulate the Treg/Th17 balance through the miR-21-5p/TLR4/MyD88/NF-κB pathway to alleviate dry eye symptoms in mice	12
A comparative genotoxicity study of agrochemicals: nuclear abnormalities, comet assay, and gene expression alterations	11
Differentiation of human endometrial mesenchymal cells to epithelial and stromal cells by seeding on the decellularized endometrial scaffold	11
Ubiquitination of ASCL1 mediates CD47 transcriptional activation of the AKT signaling pathway, and glycolysis promotes osteogenic differentiation of hBMSCs	11
The combination of neurotropic B vitamins (B1, B6, and B12) is superior to individual B vitamins in promoting neurite growth in vitro	11
Effects of centrifugation treatment before electroporation on gene editing in pig embryos	11
Synergistic effects of micropatterned substrates and transforming growth factor-β1 on differentiation of human mesenchymal stem cells into vascular smooth muscle cells through modulation of Krϋppel-li	11
Isolation and cultivation of primary muscle cells from Lobster (Homarus gammarus)	11
KHDRBS3-mediated upregulation of circ_0024107 in gastric cancer cells and GC-MSCs synergistically drives gastric cancer cell migration and invasion	10
Knockdown of ANGPTL4 inhibits adipogenesis of preadipocyte via autophagy	10
Optimization of a protocol for the high-yield isolation of active muscle stem cells from bovine skeletal muscle tissue	10
Growth factor receptor and β1 integrin signaling differentially regulate basal clonogenicity and radiation survival of fibroblasts via a modulation of cell cycling	10
An embryonic cell line from the American cockroach Periplaneta americana L. (Blattaria: Blattidae) exhibits susceptibility to AcMNPV	9
Establishment and characterization of a novel kidney cell line derived from the common bottlenose dolphin	9

In vitro differentiation of human pancreatic duct–derived PANC-1 cells into β-cell phenotype using Tinospora cordifolia	9
Macrophage pyroptosis promotes synovial fibrosis through the HMGB1/TGF- β1 axis: an in vivo and in vitro study	9
Effects of nylon mesh vitrification on the cytoskeleton, mitochondria, and aquaporins of mouse 2-cell embryos	9
Correction: The effects of carbon-ion beam irradiation on three-dimensional in vitro models of normal oral mucosa and oral cancer: development of a novel tool to evaluate cancer therapy	9
The protective effects of antioxidants against endogenous and exogenous oxidative stress on bull sperm	9
MiR-21-5p promotes RPE cell necroptosis by targeting Peli1 in a rat model of AMD	8
Compatibility of Calycosin-Tanshinone IIA improves Ang II-induced renal artery endothelial cell dysfunction through lncRNA-mRNA co-expression network	8
Study of the heterologous gene expression characteristics of a new clone of a cell line derived from Papilio xuthus and its serum-free adaptation	8
Hypoxia-inducible factor-1α promotes proliferation of airway smooth muscle cells through miRNA-103-mediated signaling pathway under hypoxia	8
Frequency-specific sensitivity of 3T3-L1 preadipocytes to low-intensity vibratory stimulus during adipogenesis	8
Pharmacoproteogenomic approach identifies on-target kinase inhibitors for cancer drug repositioning	8
Resolvin D1 suppresses inflammation in human fibroblast-like synoviocytes via the p-38, NF-κB, and AKT signaling pathways	8
Efficacy determination of a disinfectant against channel catfish virus by in vitro and in vivo methods	8
miR-155-5p can be involved in acquisition of osseointegration on titanium surface	8
Characterization and arbovirus susceptibility of cultured CERNI cells derived from sika deer (Cervus nippon)	7
The establishment of giant panda (Ailuropoda melanoleuca) fibroblast cell line	7
Nanoscale vibration could promote tenogenic differentiation of umbilical cord mesenchymal stem cells	7
Ginsenoside Rg1 treats chronic heart failure by downregulating ERK1/2 protein phosphorylation	7
Role of NF-κB signaling pathway in H2O2-induced oxidative stress of hiPSCs	7
Astragaloside promotes the secretion of MSC-derived exosomal miR-146a-5p by regulating TRAF6/NF-κB pathway to attenuate inflammation in high glucose-impaired endothelial cells	6
Ginsenoside Re promotes proliferation of murine bone marrow mesenchymal stem cells in vitro through estrogen-like action: comment	6
The adaptation of bovine embryonic stem cells to the changes of feeder layers	6
Pluripotent cells derived from 50% epiboly zebrafish embryos	6
Spheroid culture models adequately imitate distinctive features of the renal cancer or melanoma microenvironment	6
Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits	6
Knockdown of Chk1 inhibits proliferation and promotes apoptosis in mouse granulosa cells and its regulation mechanism by miR-15a and miR-16	6
Production of MSTN knockout porcine cells using adenine base-editing-mediated exon skipping	6
Cathepsin K degrades osteoprotegerin to promote osteoclastogenesis in vitro	6
FAM3A mediates the phenotypic switch of human aortic smooth muscle cells stimulated with oxidised low-density lipoprotein by influencing the PI3K-AKT pathway	6
Advancing marine invertebrate cell line research: four key knowledge gaps	6
Ginsenoside Rg1 mitigates myocardial ischemia/reperfusion injury by inhibiting NLRP3-mediated pyroptosis	6
Study on the mechanism of SAR1B in sodium acetate promoting milk fat synthesis	6
Establishment, characterization, and sensory characteristics (taste and flavor) of an immortalized muscle cell line from the seven-band grouper Epinephelus septemfasciatus: implications for cultured s	6
Joint Symposium	6
miR-106b enhances human mesenchymal stem cell differentiation to spermatogonial stem cells under germ cell profile genes involved in TGF-b signaling pathways	6
Ascorbic acid and all-trans retinoic acid promote proliferation of chicken blastoderm cells (cBCs) by mediating DNA demethylation	6
IMD/ADM2 operates as a secretory factor that controls cumulus-oocyte complexes (COCs) conformation for oocytes in vitro maturation	5
Overexpression of long non‑coding RNA H19 enhances cell viability and inhibits apoptosis in recurrent spontaneous abortion by targeting the miR-29a-3p/SOCS3 axis	5
Ulinastatin ameliorates podocyte ferroptosis via regulating miR-144-3p/SLC7A11 axis in acute kidney injury	5
JAML inhibits colorectal carcinogenesis by modulating the tumor immune microenvironment	5
Dentin matrix protein-1 promoted osteogenic differentiation of valvular interstitial cells via MAPK signal pathway during aortic valve calcification	5
Xuebijing inhibits alveolar macrophage M1 polarization by regulating ROS-mediated NLRP3 inflammasome signaling	5
Animal Symposia and Workshops	5
Novel use of a − 20°C cryoprotectant yields high viability and improved aggregation of marine sponge cells	5
Wnt signaling in cardiac development and heart diseases	5
Plant Symposia and Workshops	5
The active ingredient of Ginkgo biloba extract (quercetin) improved H2O2-induced microglia injury by activating NQO1-PI3K/Akt/mTOR signaling	5
Exosomal miR-590-3p derived from bone marrow mesenchymal stem cells promotes osteoblast differentiation and osteogenesis by targeting TGFBR1	5
Animal Contributed Papers	5
Lipoxin A4 promotes adipogenic differentiation and browning of mouse embryonic fibroblasts	5

NEURL1 acts as a candidate suppressor in bladder cancer by down-regulating PDE9A	5
In silico and in vitro evaluation of silibinin: a promising anti-Chikungunya agent	5
Establishment and characterization of epithelial and fibroblast cell lines from the bovine endometrium	5
Impact and mechanism of the TBX-22 gene mutation G874A on the epithelial-mesenchymal transition in medial edge epithelial cells	5
SERPINA3 is expressed in human adipocytes and modulated by TNF-α and vitamin B6	5
The interaction of O-GlcNAc-modified NLRX1 and IKK-α modulates IL-1β expression in M1 macrophages	5
Inhibition of FOXO3 ameliorates ropivacaine-induced nerve cell damage through the miR-126-5p/TRAF6 axis	5
Tumor endothelial cell-derived Sfrp1 supports the maintenance of cancer stem cells via Wnt signaling	4
Human embryonic stem cells maintain their stemness in three-dimensional microenvironment	4
Transfection, cytotoxicity, and cell cycle studies on the two newly developed and characterized humpback grouper (Cromileptes altivelis) fin cell lines	4
Distinguishing between ante factum and post factum properties of animal cell lines and demonstrating their use in grouping ray-finned fish cell lines into invitromes	4
IL-17A inhibits the degradation of RANKL in osteoblasts by inhibiting BCL2-Beclin1-autophagy signaling	4
Impact of repeated intravenous infusions of umbilical cord–derived versus bone marrow–derived mesenchymal stem cells on angiogenesis in a pregnant experimentally induced deep venous thrombosis rat mod	4
Therapeutic targeting of Nrf2/HO-1/NF-κB signaling axis with casticin mitigates intervertebral disc degeneration: in vitro and in vivo investigations	4
Taurine promotes insulin synthesis by enhancing Isl-1 expression through miR-7a/RAF1/ERK1/2 pathway	4
Cadmium-induced nucleus pulposus derived mesenchymal stem cells apoptosis via MAPK signaling pathway contributes to IVD degeneration	4
Wogonin improves high glucose-induced ARPE-19 cell damage by inhibiting ferroptosis via suppressing the cGAS-STING pathway	4
Correction: The adaptation of bovine embryonic stem cells to the changes of feeder layers	4
ATF4 regulates PI3K/AKT signaling axis to promote angiogenesis after myocardial infarction	4
Development and characterization of primary cell culture from the spinal cord of Asian seabass, Lates calcarifer	4
Secukinumab plays a synergistic role with starvation therapy in promoting autophagic cell death of hepatocellular carcinoma via inhibiting IL-17A-increased BCL2 level	4
A new continuous cell line from the pest insect, Anomala cuprea (Coleoptera; Scarabaeidae): emergence of contractile cells	4
Arf1 promotes porcine intestinal epithelial cell proliferation via the mTORC1 signaling pathway	4
Myricetin ameliorates the IL-21-induced tumorigenic phenotype of adjuvant-induced arthritis FLS by modulating the choline kinase signaling cascade	4
Reduced myogenic differentiation capacity of satellite cell-derived myoblasts in male ICR mice compared with male C57BL/6 and BALB/c mice	4
Generation of NPHP1 knockout human pluripotent stem cells by a practical biallelic gene deletion strategy using CRISPR/Cas9 and ssODN	4
α-Cyperone affects the development and chemosensitivity of breast cancer by modulating TRIM24	4
Generation of allogenic chimera carrying mutations in PDX1 and TP53 genes via phytohemagglutinin-mediated blastomere aggregation in pigs	4
Strongylopus grayii tadpole blastema extract exerts cytotoxic effects on embryonal rhabdomyosarcoma cells	4
TRIM9 promotes Müller cell–derived retinal stem cells to differentiate into retinal ganglion cells by regulating Atoh7	4
SIVB’s 2024 In Vitro Biology Meeting: Program, Schedule, Awards, and Acknowledgements	4
SPARC: a key mediator of apoptosis in human umbilical vein endothelial cells and its role in hypertension mechanism	4
miR-153-3p inhibited osteogenic differentiation of human DPSCs through CBFβ signaling	3
Controlling spheroid attachment improves pancreatic beta cell differentiation from human iPS cells	3
Enhanced design of pCMViR-TSC plasmid vector for sustainably high cargo gene expression in mammalian cells	3
Effects of 4-vinylcyclohexene diepoxide on the cell cycle, apoptosis, and steroid hormone secretion of goat ovarian granulosa cells	3
Understanding and manipulating extracellular behaviors of Wnt ligands	3
Extramedullary hematopoiesis: mesenchymal stromal cells from spleen provide an in vitro niche for myelopoiesis	3
Assessment of intracellular calcium and plasmalemmal membrane potential in cryopreserved metaphase II mouse oocytes	3
Ginsenoside Rg1 relieves rat intervertebral disc degeneration and inhibits IL-1β-induced nucleus pulposus cell apoptosis and inflammation via NF-κB signaling pathway	3
Role of Mydgf in the regulation of hypoxia/reoxygenation-induced apoptosis in cardiac microvascular endothelial cells	3
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis	3
Photobiomodulation therapy: a promising treatment for insulin resistance in type 2 diabetes	3
Lactiplantibacillus plantarum promotes lactoferrin synthesis and secretion in bovine mammary epithelial cells through STAT3 and AP-1 transcription factor pathways	3
IGF-1 increases survival of CD4+ lineage in a 2D model of thymocyte/thymic stromal cell co-culture	3
The interplay between Wnt signaling pathways and microtubule dynamics	3
LncRNA TDRG1 facilitates high glucose–induced retinal microvascular endothelial cell injury via miR-7-5p/G3BP2	3
2023 Special Reviewers Thank You	3
Serum starvation is as efficient as roscovitine on the cycle synchronization in G0/G1 of red-rumped agouti fibroblasts	3
In vitro inhibitory effect of zingerone on TNFα-stimulated fibroblast-like synoviocytes	3
The Berberis vulgaris L. extract berberine exerts its anti-oxidant effects to ameliorate cholesterol overloading–induced cell apoptosis in the primary mice hepatocytes: an in vitro study	3
Kinase PIM1 governs ferroptosis to reduce retinal microvascular endothelial cell dysfunction triggered by high glucose	3
Induction of cardiomyocyte calcification is dependent on FoxO1/NFATc3/Runx2 signaling	3
16th International Conference on Invertebrate and Fish Cell Culture	3
Low expression of miR-1929-3p mediates murine cytomegalovirus-induced fibrosis in cardiac fibroblasts via targeting endothelin a receptor/NLRP3 inflammasome pathway	3
Decreased ZMIZ1 suppresses melanogenesis in vitiligo by regulating mTOR/AKT/GSK-3β-mediated glucose uptake	3
Inhibition of circ_0073932 attenuates myocardial ischemia‒reperfusion injury via miR-493-3p/FAF1/JNK	3
Role of PDGFRα-mediated signalling in anoikis resistance in glioblastoma: in vitro study	3
Bilirubin impairs neuritogenesis and synaptogenesis in NSPCs by downregulating NMDAR-CREB-BDNF signaling	3
Kynurenic acid promotes osteogenesis via the Wnt/β-catenin signaling	3
Hemocytic cell line from the moth Glyphodes pyloalis (Lepidoptera: Crambidae) response to essential oils from Artemisia annua (Asterales: Asteraceae)	3
Reprogramming cultured human fungiform (HBO) taste cells into neuron-like cells through in vitro induction	3
Reversible suspension culture of human vascular smooth muscle cells using the functional biopolymer FP003	3
Overexpression of MEOX2 inhibits breast cancer cell metastasis by targeting oxidative stress-induced RGS5	3
Development and characterization of Spodoptera mauritia ovarian primary cell culture and evaluation of fenoxycarb toxicity	3
Establishment and characterization of novel spontaneously immortalized larval cell lines from sablefish Anoplopoma fimbria	3
A continuous myofibroblast precursor cell line from the tail muscle of Australasian snapper (Chrysophrys auratus) that responds to transforming growth factor beta and fibroblast growth factor	3
Education Posters	3
Liriodendrin stimulates proliferation and milk protein synthesis of mammary epithelial cells via the PI3K-DDX18 signaling	3
Generation of chimpanzee induced pluripotent stem cell lines for cross-species comparisons	3
mTORC1 signalling and protein synthesis are elevated in response to amino acids in human myotubes obtained from young, old, and old trained men	3
Epidermal growth factor increases cystathionine β-synthase expression in cultured embryonic spinal cord cells	3
Establishment and characterization of urothelial carcinoma cell lines with and without BRAF mutation (V595E) in dogs	3