Drug Delivery

Article	Citations
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation	117
Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis	101
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis	99
Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice	92
Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment	90
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery	82
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	80
Advanced hydrogel material for colorectal cancer treatment	80
Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility	70
Electroporation induced changes in extracellular vesicle profile	59
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model	58
Immunomodulatory nano-preparations for rheumatoid arthritis	57
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	57
Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant	55
Correction	55
The role of lipid particle-laden interfaces in regulating the co-delivery of two hydrophobic actives from o/w emulsions	51
Cannabidiol lymphatic transport after oral administration assessed using a novel thoracic lymph duct cannulated conscious pig model	50
Correction	49
Electrospun PVP/HPBCD nanofiber topical drug delivery platform for enhanced skin permeability and anti-pollution bioactivity of Artocarpus altilis extrac	49
Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats	48
Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach	47
Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques	46
Surface functionalized nanomaterial systems for targeted therapy of endocrine related tumors: a review of recent advancements	46
Effect and mechanism of paclitaxel loaded on magnetic Fe 3 O 4 @mSiO 2	45
Microneedle-based injection of Fungizone/Amphotericin B: an effective treatment for American cutaneous leishmaniasis in mice	45

Advance in placenta drug delivery: concern for placenta-originated disease therapy	45
Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management	44
Lysosome-directed targeted protein degradation technologies for overcoming cancer drug resistance: mechanisms, design principles, and therapeutic opportunities	42
Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin	41
Boosting the anti MERS-CoV activity and oral bioavailability of resveratrol via PEG-stabilized emulsomal nano-carrier: Factorial design, in-vitro and in-vivo assessments	40
SREKA-targeted liposomes for highly metastatic breast cancer therapy	40
Platinum-based drugs and hydrogel: a promising anti-tumor combination	39
The development of DNA delivery system based on ionic liquid and carboxylic acid modified polyethyleneimine	38
Recent trends in platelet membrane-cloaked nanoparticles for application of inflammatory diseases	38
Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective	37
Application of chitosan-based drug delivery systems in the treatment of bacterial diseases: a review	37
Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation	37
Tumor microenvironment-responsive conformational activation of apoA-I mimetic peptides for targeted cancer therapy	37
PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide	37
Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs	37
PEGylation technology: addressing concerns, moving forward	36
PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA	36
Statement of Retraction: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin	36
Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling	35
Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2	35
Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy	35
Low-intensity pulsed ultrasound combined with microbubbles enhances amphotericin B delivery across the blood–brain barrier for improved therapy of cryptococcal meningitis	35
Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro	35
Next-generation composite vesicular systems: an in-depth review of proniosomes in advanced drug delivery	34
Lipid nanoparticles with aptamers enable targeted mRNA delivery to CD4⁺ T cells	33
First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring	33
Harnessing fluorescent probes for molecular diagnosis and theranostics of atherosclerosis	33
Design and characterization of a resveratrol spray-dried inhalable formulation for pulmonary delivery with in vivo pharmacokinetic and toxicological eval	33
Nucleic acid-encoded antibody gene transfer-next generation of antibody therapies	32
In vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats	32
Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	32
The effect of surfactant type on characteristics, skin penetration and anti-aging effectiveness of transfersomes containing amniotic mesenchymal stem cells metabolite products in UV-aging induced mice	32
FEA-guided co-design of bubble microneedles: controlled tip separation for rapid transdermal and sublingual delivery	32
Wedelactone-loaded exosomes for sepsis-induced liver injury: a novel therapeutic strategy	31
A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors	31
Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques	31
Design and applications of liposome-in-gel as carriers for cancer therapy	30
Integrating micro-needle jet injection and sustained GLP-1 therapy with structured feeding: a comprehensive strategy for obesity management	30
Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum	30
Modeling the synergistic enhancement of drug permeation by a dual-microbubble system under ultrasonic excitation	29
Ginsenoside compound K-based multifunctional liposomes for the treatment of rheumatoid arthritis	29
Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note	29
Immunomodulator loaded microneedle arrays for targeted intradermal drug delivery to skin tumors	29
The colloidal stability of albumin-based drug delivery systems has a profound effect on tumoricidal activity	29
Self-assembled non-steroidal anti-inflammatory drug-peptide hydrogel to effectively mitigate ocular inflammation	29
Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy	29
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model	29
Development of a drug delivering round window niche implant for cochlear pharmacotherapy	28
Selective expansion and differentiation of antigen-specific CD4 + T-helper cells by engineered extracellular vesicles	28
Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes	28

Extravasation of biodegradable microspheres in the rat brain	28
Utilization of DOX–Fe complex and RSL3 co-loaded liposomes in ferroptosis-enhanced treatment of triple-negative breast cancer	28
Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor	27
Correction notice	27
Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives	27
Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model	27
Nanomaterial-mediated multidimensional regulation of the bone microenvironment: a precise therapeutic strategy for bone metabolic imbalance	26
Advancements and challenges in ophthalmic microneedles to treat eye diseases	26
Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles	26
Advances in vaccine adjuvant development and future perspectives	26
A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy	26
Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice	26
Drug retention after intradiscal administration	25
Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis	25
Induction of antigen-specific regulatory T cells by engineered extracellular vesicles	25
Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a preclinical approach to rheumatoid arthritis management	25
Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules	25
Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases	24
A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma	24
Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion	24
Triptolide and l -ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation	24
Novel nano-carriers with N-formylmethionyl-leucyl-phenylalanine-modified liposomes improve effects of C16-angiopoietin 1 in acute animal model of multiple sclerosis	24
Advances in cell membrane-based biomimetic nanodelivery systems for natural products	24
Self-micellizing solid dispersion of thymoquinone with enhanced biopharmaceutical and nephroprotective effects	24
Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells	24
Liposome-mediated delivery of a ruthenium-based metallodrug to overcome cisplatin resistance in osteosarcoma	23
Long-term management of psoriasis recurrence via modulation of cutaneous microbiome: synergistic topical therapy with blue light and aptamer-functionalized curcumin formulation	23
Multi-functional chitosan copolymer modified nanocrystals as oral andrographolide delivery systems for enhanced bioavailability and anti-inflammatory efficacy	23
Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticle	23
Unlocking the “undruggable”: current landscape and emerging frontiers in lysosomal receptor-mediated protein degradation	23
Ultrasound targeted microbubbles for theranostic applications in liver diseases: from molecular imaging to targeted therapy	23
Brain-targeted delivery of Valsartan using solid lipid nanoparticles labeled with Rhodamine B; a promising technique for mitigating the negative effects of stroke	22
Tailoring and optimization of a honey-based nanoemulgel loaded with an itraconazole–thyme oil nanoemulsion for oral candidiasis	22
Evaluating nurse preferences for a novel on-body delivery system vs. manual syringes for large-volume subcutaneous drug administration: a survey study	22
Cancer targeted drug delivery using active low-density lipoprotein nanoparticles encapsulated pyrimidines heterocyclic anticancer agents as microtubule inhibitors	22
Ionic liquid-iontophoresis mediates transdermal delivery of sparingly soluble drugs	21
Preparation and in vivo evaluation of an intravenous emulsion loaded with an aprepitant-phospholipid complex	21
Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges	21
A novel saponin liposomes based on the couplet medicines of Platycodon grandiflorum–Glycyrrhiza uralensis for targeting lung cancer	21
Exploiting the dynamics of hyperthermia-enhanced delivery of thermosensitive liposomal doxorubicin to solid tumors	21
Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo	21
Kartogenin delivery systems for biomedical therapeutics and regenerative medicine	21
Surface-tailoring of emulsomes for boosting brain delivery of vinpocetine via intranasal route: in vitro optimization and in vivo<	21
Polymersome-based nanomedicine for combined cancer therapy	21
Mechanics of small intestine motility for oral macromolecular delivery: modelling segmentation versus peristalsis	20
Dual-ligand-modified cantharidin nanoparticles for the treatment of hepatocellular carcinoma via the inhibition of Ephb4	20
Oral administration of Huanglian-Houpo herbal nanoemulsion loading multiple phytochemicals for ulcerative colitis therapy in mice	20
Current status and advances in esophageal drug delivery technology: influence of physiological, pathophysiological and pharmaceutical factors	20
Gadolinium-based MR cisternography with prepontine cisternal routine for evaluating distribution pattern of intrathecal targeted drug delivery in pain management	19
Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective	19
Optimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation	19
Polycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization and in vivo burn wound healing activity	19
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity	19
Aptamer-mediated liver-targeted curcumin delivery system based on tetrahedral framework nucleic acids for NAFLD	19
Correction notice	19
Synergy effects of copper ion in doxorubicin-based chelate prodrug for cancer chemo-chemodynamic combination therapy	19
Research progress of ophthalmic preparations of immunosuppressants	18
Nanotherapeutics for enhanced treatments for ovarian cancer: a comprehensive minireview	18
Improving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks	18
An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis	18
Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model	18
Lipidization as a tool toward peptide therapeutics	18
Advances in oral treatment of inflammatory bowel disease using protein-based nanoparticle drug delivery systems	17
Cryopreservation technology for improving the stability of liposomes and its precise drug monitoring in clinical drug research	17
Orchestrating T and NK cells for tumor immunotherapy via NKG2A-targeted delivery of a de novo designed IL-2Rβγ agonist	16
Formulation and characterization of lamotrigine nasal insert targeted brain for enhanced epilepsy treatment	16
Enhancement of the anticancer effect of atorvastatin-loaded nanoemulsions by improving oral absorption via multivalent intestinal transporter-targeting lipids	16
Photo-crosslinkable polyester microneedles as sustained drug release systems toward hypertrophic scar treatment	16
Ferric-loaded lipid nanoparticles inducing ferroptosis-like cell death for antibacterial wound healing	16
RETRACTED: Statement of Retraction	16
Enhanced in vitro and in vivo antifungal efficacy against Candida albicans	16
In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma	16
A surrogate barrier model for high-throughput blood-brain barrier permeability prediction: integrating LLC-PK1-MOCK/MDR1 Cells and lysosomal trapping correction	16
Harnessing nanofibers for targeted delivery of phytoconstituents in age-related macular degeneration	16
Valency-affinity mapping of multivalent liposomes for tunable target cell discrimination	16
Blood-cerebrospinal fluid barrier opening by modified single pulse transcranial focused shockwave	15
Ophthalmic formulation of methotrexate: a strategy of using the self-assembled LacAC4A nanoparticles for non-invasive drug delivery to the ocular posterior segment	15
Identifying a predictive relationship between maximal flow rate and viscosity for subcutaneous administration of macromolecules with recombinant human hyaluronidase PH20 in a miniature pig model	15
Novel tetrahydrocurcumin integrated mucoadhesive nanocomposite κ-carrageenan/xanthan gum sponges: a strategy for effective local treatment of oral cancerous and precancerous lesions	15
‘Mito-Bomb’: a novel mitochondria-targeting nanosystem for ferroptosis-boosted sonodynamic antitumor therapy	14

Tumor-derived extracellular vesicles for the active targeting and effective treatment of colorectal tumors in vivo	14
Microalgae as novel drug-delivery system for biomedical field	14
Development of a novel alpha7-nicotinic acetylcholine receptor-selective cell-penetrating peptide for intracellular cargo transport	14
Progress in the application of hydrogels in immunotherapy of gastrointestinal tumors	14
Biomaterial-based drug delivery: evaluating the safety profiles of liposomal Vyxeos	14
Non-Viral CRISPR carriers: transient delivery with lasting effects	14
Cerium oxide nanoparticles: antioxidant properties in silicosis treatment and biomedical application prospects—a dialectical consideration	14
Advanced cell-derived drug delivery systems for pulmonary diseases: from bench to bedside	14
Biomimetic peptide conjugates as emerging strategies for controlled release from protein-based materials	14
HI-6-loaded PEGylated liposomes: an on-site first-aid strategy for acute organophosphorus agent poisoning	14
Reliable high-PAP-1-loaded polymeric micelles for cancer therapy: preparation, characterization, and evaluation of anti-tumor efficacy	14
Drug delivery in leptomeningeal disease: Navigating barriers and beyond	14
Increased brain uptake of pterostilbene loaded folate modified micellar delivery system	13
Biodegradable polymeric insulin microneedles – a design and materials perspective review	13
Enhancing GSDME-induced pyroptosis through low-dose doxorubicin/biflavonoid derivative co-loaded nanodisc in hepatocellular carcinoma	13
Stability of polymeric cationic niosomes and their plasmid DNA-based complexes as gene delivery carriers	13
Prostate-specific membrane antigen targeted, glutathione-sensitive nanoparticles loaded with docetaxel and enzalutamide for the delivery to prostate cancer	13
Fabrication of nanostructured lipid carriers ocugel for enhancing Loratadine used in treatment of COVID-19 related symptoms: statistical optimization, in-vitro	12
Tumor microenvironment-responsive micelles assembled from a prodrug of mitoxantrone and 1-methyl tryptophan for enhanced chemo-immunotherapy	12
Polysaccharide dextran-based conjugate for selective co-delivery of two synergistic drugs docetaxel and docosahexaenoic acid to tumor cells	12
External stimuli-responsive drug delivery to the posterior segment of the eye	12
MPET 2 : a multi-network poroelastic and transport theory for predicting absorption of monoclonal antibodies delivered by subcutaneous injection	12
Hydroxypropyl chitosan nail lacquer of ciclopirox-PLGA nanocapsules for augmented in vitro nail plate absorption and onychomycosis treatment	12
Development and evaluation of alginate-based gastroretentive raft-forming systems enabling sustained release of propolis in gastric ulcer treatment	12
Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform	12
Breakthroughs of ultrasound-targeted microbubble destruction in treating myocardial ischemia-reperfusion injury: from angiogenesis regulation to precise inflammation suppression	11
Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design	11
Efficacy, safety, and patient-centered outcomes of needle-free injectors versus insulin pens in diabetes management: a comprehensive meta-analysis	11
A mini-review on gene delivery technique using nanoparticles-mediated photoporation induced by nanosecond pulsed laser	11
Application of iontophoresis in ophthalmic practice: an innovative strategy to deliver drugs into the eye	11
A detailed insight of the tumor targeting using nanocarrier drug delivery system	11
Correction Notice	11
Syringeable atorvastatin loaded eugenol enriched PEGylated cubosomes in-situ gel for the intra-pocket treatment of periodontitis: statistical optimization and clinical assessment	11
Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review	11
Impact of nebulizers on nanoparticles-based gene delivery efficiency: in vitro and in vivo comparison of j	11
Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina	11
Folic acid-modified reverse micelle-lipid nanocapsules overcome intestinal barriers and improve the oral delivery of peptides	11
Negatively charged phospholipids doped liposome delivery system for mRNA with high transfection efficiency and low cytotoxicity	11
Phytic acid-modified manganese dioxide nanoparticles oligomer for magnetic resonance imaging and targeting therapy of osteosarcoma	11
Recent advances of injectable in situ-forming hydrogels for preventing postoperative tumor recurrence	11