OOIR: Observatory of International Research

Papers

(The TQCC of Drug Delivery is 22. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice	198
Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity	191
Advanced hydrogel material for colorectal cancer treatment	186
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery	154
Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis	141
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model	137
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation	133
Immunomodulatory nano-preparations for rheumatoid arthritis	117
Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility	93
Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment	89
Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems	76
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis	76
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	70
Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice	67
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	64
Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy	64
Surface functionalized nanomaterial systems for targeted therapy of endocrine related tumors: a review of recent advancements	58
Pitavastatin-loaded bilosomes for oral treatment of hepatocellular carcinoma: a repurposing approach	58
Thermo-sensitive self-assembly of poly(ethylene imine)/(phenylthio) acetic acid ion pair in surfactant solutions	58
Development of a single-dose Q fever vaccine with an injectable nanoparticle-loaded hydrogel: effect of sustained co-delivery of antigen and adjuvant	57
Formulation of novel niosomal repaglinide chewable tablets using coprocessed excipients: in vitro characterization, optimization and enhanced hypoglycemic activity in rats	53
The role of lipid particle-laden interfaces in regulating the co-delivery of two hydrophobic actives from o/w emulsions	53
Effect of pH-sensitive nanoparticles on inhibiting oral biofilms	52
The discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics	51
Correction	50

Effect and mechanism of paclitaxel loaded on magnetic Fe ₃ O ₄ @mSiO ₂ -NH ₂	49
Quantitative analysis of therapeutic proteins in biological fluids: recent advancement in analytical techniques	47
Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin	47
Exploring the efficacy and constraints of platinum nanoparticles as adjuvant therapy in silicosis management	46
Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer	46
Nanoparticles-based anti-aging treatment of Alzheimer’s disease	46
Orally administered intelligent self-ablating nanoparticles: a new approach to improve drug cellular uptake and intestinal absorption	45
Advance in placenta drug delivery: concern for placenta-originated disease therapy	45
SREKA-targeted liposomes for highly metastatic breast cancer therapy	45
Development, optimization, and evaluation of a nanostructured lipid carrier of sesame oil loaded with miconazole for the treatment of oral candidiasis	45
Boosting the anti MERS-CoV activity and oral bioavailability of resveratrol via PEG-stabilized emulsomal nano-carrier: Factorial design, in-vitro and in-vivo assessments	44
Recent trends in platelet membrane-cloaked nanoparticles for application of inflammatory diseases	44
Platinum-based drugs and hydrogel: a promising anti-tumor combination	44
PEGylated pH-responsive peptide-mRNA nano self-assemblies enhance the pulmonary delivery efficiency and safety of aerosolized mRNA	43
Application of chitosan-based drug delivery systems in the treatment of bacterial diseases: a review	43
Optimization of mirtazapine loaded into mesoporous silica nanostructures via Box-Behnken design: in-vitro characterization and in-vivo assessment	43
Disordered mesoporous silica particles: an emerging platform to deliver proteins to the lungs	43
Targeting interleukin-13 receptor α2 (IL-13Rα2) for glioblastoma therapy with surface functionalized nanocarriers	42
Multiple delivery strategies of nanocarriers for myocardial ischemia-reperfusion injury: current strategies and future prospective	42
PEGylation technology: addressing concerns, moving forward	42
Multifunctional icariin and tanshinone IIA co-delivery liposomes with potential application for Alzheimer’s disease	42
Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles	41
Nanotransethosomes for enhanced transdermal delivery of mangiferin against rheumatoid arthritis: formulation, characterization, invivo pharmacokinetic and pharmacodynamic evaluation	41
PEGylated Tween 80-functionalized chitosan-lipidic nano-vesicular hybrids for heightening nose-to-brain delivery and bioavailability of metoclopramide	41
Delivery of rivaroxaban and chitosan rapamycin microparticle with dual antithrombosis and antiproliferation functions inhibits venous neointimal hyperplasia	40
First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring	40
Research progress of the engagement of inorganic nanomaterials in cancer immunotherapy	40
Development of canagliflozin nanocrystals sublingual tablets in the presence of sodium caprate permeability enhancer: formulation optimization, characterization, in-vitro	40
Statement of Retraction: Bicomponent polymeric micelles for pH-controlled delivery of doxorubicin	40
Boosting the anti-inflammatory effect of self-assembled hybrid lecithin–chitosan nanoparticles via hybridization with gold nanoparticles for the treatment of psoriasis: elemental mapping and in viv	39
Modification of sodium aescinate into a safer, more stable and effective water-soluble drug by liposome-encapsulation: anin vitroandin vivostudy	39
PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo	39
Colon specific delivery of miR-155 inhibitor alleviates estrogen deficiency related phenotype via microbiota remodeling	38
Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy	38
In vivo pharmacokinetic and pharmacodynamic study of co-spray-dried inhalable pirfenidone microparticles in rats	38
Preparation of PEG/ZIF-8@HF drug delivery system for melanoma treatment via oral administration	37
Enhanced anti-glioma activity of annonaceous acetogenins based on a novel liposomal co-delivery system with ginsenoside Rh2	36
Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy	36
Artificial intelligence-assisted development ofin situforming nanoparticles for arthritis therapy via intra-articular delivery	35
Solid lipid nanoparticles to improve bioaccessibility and permeability of orally administered maslinic acid	35
Intricate subcellular journey of nanoparticles to the enigmatic domains of endoplasmic reticulum	35
Oxaliplatin-loaded nanoemulsion containingTeucrium poliumL. essential oil induces apoptosis in Colon cancer cell lines through ROS-mediated pathway	34
Safety and biocompatibility of a novel biodegradable aflibercept-drug delivery system in rhesus macaques	34
A spatiotemporal computational model of focused ultrasound heat-induced nano-sized drug delivery system in solid tumors	34
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment	33
Targeting therapy effects of composite hyaluronic acid/chitosan nanosystems containing inclusion complexes	33
Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note	33
Potentiality of raloxifene loaded melittin functionalized lipidic nanovesicles against pancreatic cancer cells	33
Metal nanoparticles as a promising technology in targeted cancer treatment	33
Monolith/Hydrogel composites as triamcinolone acetonide carriers for curing corneal neovascularization in mice by inhibiting the fibrinolytic system	33

Design and applications of liposome-in-gel as carriers for cancer therapy	33
Thioctamer: a novel thioctic acid–glatiramer acetate nanoconjugate expedites wound healing in diabetic rats	32
Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models	32
Immunomodulator loaded microneedle arrays for targeted intradermal drug delivery to skin tumors	32
Chitosan-dipotassium orthophosphate lyophilizate: a novel in situ thermogel carrier system of allogeneic platelet lysate growth factors	32
Selective expansion and differentiation of antigen-specific CD4 ⁺ T-helper cells by engineered extracellular vesicles	31
Ginsenoside compound K-based multifunctional liposomes for the treatment of rheumatoid arthritis	31
Extravasation of biodegradable microspheres in the rat brain	31
Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes	31
Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy	31
A recombinant scFv antibody-based fusion protein that targets EGFR associated with IMPDH2 downregulation and its drug conjugate show therapeutic efficacy against esophageal cancer	30
Pharmacokinetic improvement provided by microneedle patch in delivering bee venom, a case study in combating scopolamine-induced neurodegeneration in mouse model	30
Correction notice	30
A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy	30
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model	30
Responsive nanosystems for targeted therapy of ulcerative colitis: Current practices and future perspectives	29
Advances in vaccine adjuvant development and future perspectives	29
Novel cannula design improves large volume auto-injection rates for high viscosity solutions	29
Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor	28
Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer	28
Self-emulsifying drug delivery systems: a novel approach to deliver drugs	28
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis	27
Iodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy	27
Cell membrane-camouflaged PLGA biomimetic system for diverse biomedical application	27
Development of a drug delivering round window niche implant for cochlear pharmacotherapy	27
A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy	27
GRP78-targeted and doxorubicin-loaded nanodroplets combined with ultrasound: a potential novel theranostics for castration-resistant prostate cancer	26
Oral delivery of bi-autoantigens by bacterium-like particles (BLPs) against autoimmune diabetes in NOD mice	26
Ethosomal gel for rectal transmucosal delivery of domperidone: design of experiment, in vitro, and in vivo evaluation	26
Novel ethosomal gel formulation for enhanced transdermal delivery of curcumin and cyclosporine: a preclinical approach to rheumatoid arthritis management	26
Sustained release of brimonidine from BRI@SR@TPU implant for treatment of glaucoma	26
Drug retention after intradiscal administration	26
Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity	25
A non-invasive direct nose to brain drug delivery platform vs. invasive brain delivery approach: patient-centered care impact analysis	25
Formulation of the novel structure curcumin derivative–loaded solid lipid nanoparticles: synthesis, optimization, characterization and anti-tumor activity screening in vitro	25
Polysialic acid-functionalized liposomes for efficient honokiol delivery to inhibit breast cancer growth and metastasis	25
Multi-fractal modeling of curcumin release mechanism from polymeric nanomicelles	25
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis	24
Self-micellizing solid dispersion of thymoquinone with enhanced biopharmaceutical and nephroprotective effects	24
Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β signaling molecules	24
Nanomicelles for GLUT1-targeting hepatocellular carcinoma therapy based on NADPH depletion	24
Phenylboronic ester-modified polymeric nanoparticles for promoting TRP2 peptide antigen delivery in cancer immunotherapy	24
Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer	23
Design of chitosan colon delivery micro/nano particles for an Achillea millefolium extract with antiproliferative activity against colorectal cancer cells	23
Implementing polymeric pseudorotaxanes for boosting corneal permeability and antiaspergillus activity of tolnaftate: formulation development, statistical optimization, ex vivo permeation and in vivo a	23
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3	23
Development, in vitro and ex vivo characterization of lamotrigine-loaded bovine serum albumin nanoparticles using QbD approach	23
Novel nano-carriers with N-formylmethionyl-leucyl-phenylalanine-modified liposomes improve effects of C16-angiopoietin 1 in acute animal model of multiple sclerosis	23
Advances in smart delivery of magnetic field-targeted drugs in cardiovascular diseases	23
Ultrasound targeted microbubbles for theranostic applications in liver diseases: from molecular imaging to targeted therapy	23
A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma	22
Carbopol emulgel loaded with ebastine for urticaria: development, characterization,in vitroandin vivoevaluation	22
GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance	22
Advances in cell membrane-based biomimetic nanodelivery systems for natural products	22
Triptolide and l-ascorbate palmitate co-loaded micelles for combination therapy of rheumatoid arthritis and side effect attenuation	22
Evaluating nurse preferences for a novel on-body delivery system vs. manual syringes for large-volume subcutaneous drug administration: a survey study	22
Nanocrystals based pulmonary inhalation delivery system: advance and challenge	22
Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis	22