OOIR: Observatory of International Research

Papers

(The TQCC of Drug Delivery is 19. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-04-01 to 2025-04-01.)

Article	Citations
Fabrication of bio-engineered chitosan nanoformulations to inhibition of bacterial infection and to improve therapeutic potential of intestinal microflora, intestinal morphology, and immune response i	179
Transdermal delivery of colchicine using dissolvable microneedle arrays for the treatment of acute gout in a rat model	150
The treatment efficacy of three-layered functional polymer materials as drug carrier for orthotopic colon cancer	150
Incompatibility of antimalarial drugs: challenges in formulating combination products for malaria	137
Pronounced capping effect of olaminosomes as nanostructured platforms in ocular candidiasis management	117
Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice	114
Exploring the effects of cannabidiol encapsulation in liposomes on their physicochemical properties and biocompatibility	101
Formulation and characterization of eprosartan mesylate and β-cyclodextrin inclusion complex prepared by microwave technology	85
Mesoporous tantalum oxide nanomaterials induced cardiovascular endothelial cell apoptosis via mitochondrial-endoplasmic reticulum stress apoptotic pathway	77
Dendritic cell combination therapy reduces the toxicity of triptolide and ameliorates colitis in murine models	73
Aptamer-mediated hollow MnO ₂ for targeting the delivery of sorafenib	59
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	57
Arenobufagin-loaded PEG-PLA nanoparticles for reducing toxicity and enhancing cancer therapy	56
Development of surface modified bilosomes for the oral delivery of quercetin: optimization, characterization in-vitro antioxidant, antimicrobial, and cytotoxicity study	54
Poloxamer sols endowed with in-situ gelability and mucoadhesion by adding hypromellose and hyaluronan for prolonging corneal retention and drug delivery	50
Chitosan-dipotassium orthophosphate lyophilizate: a novel in situ thermogel carrier system of allogeneic platelet lysate growth factors	48
Green synthesis and characterization of gold nanoparticles from Pholiota adiposa and their anticancer effects on hepatic carcinoma	47
Rapid oral transmucosal delivery of zaleplon–lavender oil utilizing self-nanoemulsifying lyophilized tablets technology: development, optimization and pharmacokinetic evaluation	47
Construction of iron-mineralized black phosphorene nanosheet to combinate chemodynamic therapy and photothermal therapy	45
Preparation of baicalin-loaded ligand-modified nanoparticles for nose-to-brain delivery for neuroprotection in cerebral ischemia	45
Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution	43
Compression-coated pulsatile chronomodulated therapeutic system: QbD assisted optimization	43
The efficacy ofOriganum majoranananocubosomal systems in ameliorating submandibular salivary gland alterations in streptozotocin-induced diabetic rats	42
Nanomaterials in tuberculosis DNA vaccine delivery: historical perspective and current landscape	42
Statement of Retraction: A convergent synthetic platform for dual anticancer drugs functionalized by reduced graphene nanocomposite delivery for hepatocellular cancer	41

Ginsenoside compound K-based multifunctional liposomes for the treatment of rheumatoid arthritis	41
Targeted drug delivery strategy: a bridge to the therapy of diabetic kidney disease	41
Quality by design aided self-nano emulsifying drug delivery systems development for the oral delivery of Benidipine: Improvement of biopharmaceutical performance	41
Intra-articular injection PLGA blends sustained-release microspheres loaded with meloxicam: preparation, optimization, evaluation in vitro and in vivo	40
Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell ana	39
Nose to brain delivery of melatonin lipidic nanocapsules as a promising post-ischemic neuroprotective therapeutic modality	39
A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy	37
Evaluation of the hepatoprotective effect of naringenin loaded nanoparticles against acetaminophen overdose toxicity	37
Development of microparticles for oral administration of Periplaneta americana extract to treat ulcerative colitis	36
Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles	35
Guanidine-modified albumin-MMAE conjugates with enhanced endocytosis ability	35
Rationalized design to explore the full potential of PLGA microspheres as drug delivery systems	35
Advances in drug delivery systems utilizing blood cells and their membrane-derived microvesicles	35
Statement of Retraction	35
D-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes	35
The development and evaluation of hyaluronic acid coated mitochondrial targeting liposomes for celastrol delivery	35
Homotypic cell membrane-camouflaged biomimetic PLGA nanoparticle loading triptolide for the treatment of hepatocellular carcinoma	35
K. Zheng et al. Gold-nanoparticle-based multistage drug delivery system for antitumor therapy	34
Synergy effects of copper ion in doxorubicin-based chelate prodrug for cancer chemo-chemodynamic combination therapy	34
Transferrin receptor targeting segment T7 containing peptide gene delivery vectors for efficient transfection of brain tumor cells	34
Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective	33
Gadolinium-based MR cisternography with prepontine cisternal routine for evaluating distribution pattern of intrathecal targeted drug delivery in pain management	33
Monolith/Hydrogel composites as triamcinolone acetonide carriers for curing corneal neovascularization in mice by inhibiting the fibrinolytic system	33
Paclitaxel-loaded ROS-responsive nanoparticles for head and neck cancer therapy	33
Research progress of ophthalmic preparations of immunosuppressants	33
Single pot organic solvent-free thermocycling technology for siRNA-ionizable LNPs: a proof-of-concept approach for alternative to microfluidics	32
Development of an apolipoprotein E mimetic peptide–lipid conjugate for efficient brain delivery of liposomes	32
Utilization of a nanostructured lipid carrier encapsulating pitavastatin– Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line	32
Improving curcumin bactericidal potential against multi-drug resistant bacteria via its loading in polydopamine coated zinc-based metal–organic frameworks	32
The nanoprodrug of polytemozolomide combines with MGMT siRNA to enhance the effect of temozolomide in glioma	31
Optimal treatment occasion for ultrasound stimulated microbubbles in promoting gemcitabine delivery to VX2 tumors	31
An update on the advances in the field of nanostructured drug delivery systems for a variety of orthopedic applications	30
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	30
Formulation of a dual drug-loaded nanoparticulate co-delivery hydrogel system and its validation in rheumatoid arthritis animal model	30
Advanced hydrogel material for colorectal cancer treatment	30
Risedronate-loaded aerogel scaffolds for bone regeneration	30
Co-delivery of amphotericin B and pentamidine loaded niosomal gel for the treatment of Cutaneous leishmaniasis	29
Polycaprolactone based pharmaceutical nanoemulsion loaded with acriflavine: optimization andin vivoburn wound healing activity	29
Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity	29
Synthesized nano particles of glimepiride via spray freezing into cryogenic liquid: characterization, antidiabetic activity, and bioavailability	28
Prepontine cisternal routine for intrathecal targeted drug delivery in craniofacial cancer pain treatment: technical note	28
Magnesium ascorbyl phosphate vesicular carriers for topical delivery; preparation, in-vitro and ex-vivo evaluation, factorial optimization and clinical assessment in melasma patients	28
Correction notice	28
Silk nanoparticles for the protection and delivery of guava leaf ( Psidium guajava L.) extract for cosmetic industry, a new approach for an old herb	28
An injectable hydrogel to disrupt neutrophil extracellular traps for treating rheumatoid arthritis	28
Mitochondria targeting molecular transporters: synthesis, lipophilic effect, and ionic complex	27
Nano-liposomal zein hydrolysate for improved apoptotic activity and therapeutic index in lung cancer treatment	27
Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy	27
Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment	27
Acoustic triggered nanobomb for US imaging guided sonodynamic therapy and activating antitumor immunity	27

Disitamab vedotin: a novel antibody-drug conjugates for cancer therapy	27
Preparation and optimization of aloe ferox gel loaded with Finasteride-Oregano oil nanocubosomes for treatment of alopecia	26
Hyaluronic acid-enriched bilosomes: an approach to enhance ocular delivery of agomelatine via D-optimal design: formulation, in vitro characterization, and in vivo pharmacodynamic evalua	26
Biomimetic virus-like mesoporous silica nanoparticles improved cellular internalization for co-delivery of antigen and agonist to enhance Tumor immunotherapy	26
Metformin HCl-loaded transethosomal gel; development, characterization, and antidiabetic potential evaluation in the diabetes-induced rat model	26
Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems	25
Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice	25
Lipidization as a tool toward peptide therapeutics	25
Thioctamer: a novel thioctic acid–glatiramer acetate nanoconjugate expedites wound healing in diabetic rats	25
Formulation and evaluation of Piroxicam nanosponge for improved internal solubility and analgesic activity	24
Immunomodulatory nano-preparations for rheumatoid arthritis	24
Hyaluronic acid-based nanoparticles to deliver drugs to the ocular posterior segment	24
Extravasation of biodegradable microspheres in the rat brain	24
Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects	24
Dual-responsive nanosystem based on TGF-β blockade and immunogenic chemotherapy for effective chemoimmunotherapy	23
Enzyme-triggered- and tumor-targeted delivery with tunable, methacrylated poly(ethylene glycols) and hyaluronic acid hybrid nanogels	23
Oral liposomal delivery of an activatable budesonide prodrug reduces colitis in experimental mice	23
Construction and application of microneedle-mediated photothermal therapy and immunotherapy combined anti-tumor drug delivery system	23
Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective colon cancer therapy	23
Optimization of hyaluronan-enriched cubosomes for bromfenac delivery enhancing corneal permeation: characterization, ex vivo, and in vivo evaluation	23
A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy	23
Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models	23
Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment	23
Thermo-sensitive self-assembly of poly(ethylene imine)/(phenylthio) acetic acid ion pair in surfactant solutions	22
The cell type dependent sorting of CD9- and CD81 to extracellular vesicles can be exploited to convey tumor sensitive cargo to target cells	22
A systematic review of liposomal nanofibrous scaffolds as a drug delivery system: a decade of progress in controlled release and therapeutic efficacy	22
Enhanced therapeutic efficacy of doxorubicin against multidrug-resistant breast cancer with reduced cardiotoxicity	22
Treatment efficacy of low-dose 5-fluorouracil with ultrasound in mediating 5-fluorouracil-loaded microbubble cavitation in head and neck cancer	21
Application of mPEG-CS-cRGD/ Bmi-1RNAi -PTX nanoparticles in suppression of laryngeal cancer by targeting cancer stem cells	21
Development of a naringenin microemulsion as a prospective ophthalmic delivery system for the treatment of corneal neovascularization: in vitro and in vivo evaluation	20
The role of lipid particle-laden interfaces in regulating the co-delivery of two hydrophobic actives from o/w emulsions	20
The discovery of berberine erythrocyte-hemoglobin self-assembly delivery system: a neglected carrier underlying its pharmacokinetics	20
Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives	20
Cell membrane-camouflaged PLGA biomimetic system for diverse biomedical application	20
Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management	20
Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy	20
Formulation and characterization of lamotrigine nasal insert targeted brain for enhanced epilepsy treatment	19
Ferric-loaded lipid nanoparticles inducing ferroptosis-like cell death for antibacterial wound healing	19
Hyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin	19
Biodegradable gemcitabine-loaded microdevice with sustained local drug delivery and improved tumor recurrence inhibition abilities for postoperative pancreatic tumor treatment	19
Design and optimization of silymarin loaded in lyophilized fast melt tablets to attenuate lung toxicity induced via HgCl₂ in rats	19
Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization	19
Impact of particle size of multivesicular liposomes on the embolic and therapeutic effects in rabbit VX2 liver tumor	19