Drug Delivery

Article	Citations
PLGA-based biodegradable microspheres in drug delivery: recent advances in research and application	196
Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis	96
Metal nanoparticles as a promising technology in targeted cancer treatment	82
Preservation of small extracellular vesicles for functional analysis and therapeutic applications: a comparative evaluation of storage conditions	78
Disitamab vedotin: a novel antibody-drug conjugates for cancer therapy	77
Nano-drug co-delivery system of natural active ingredients and chemotherapy drugs for cancer treatment: a review	71
Cell-derived biomimetic nanocarriers for targeted cancer therapy: cell membranes and extracellular vesicles	66
Preserving extracellular vesicles for biomedical applications: consideration of storage stability before and after isolation	66
Progress in the development of stabilization strategies for nanocrystal preparations	60
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis	60
Poly(lactic-co-glycolic acid) microsphere production based on quality by design: a review	59
Application of chitosan/alginate nanoparticle in oral drug delivery systems: prospects and challenges	59
Preparation and characterization of 2-hydroxyethyl starch microparticles for co-delivery of multiple bioactive agents	54
Drug delivery of amoxicillin molecule as a suggested treatment for covid-19 implementing functionalized mesoporous SBA-15 with aminopropyl groups	54
Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery	51
Functional ligands for improving anticancer drug therapy: current status and applications to drug delivery systems	51
Formulation, characterization, and cellular toxicity assessment of tamoxifen-loaded silk fibroin nanoparticles in breast cancer	50
Recent advances in the local antibiotics delivery systems for management of osteomyelitis	50
Intra-articular drug delivery systems for osteoarthritis therapy: shifting from sustained release to enhancing penetration into cartilage	49
Hypoxia responsive nano-drug delivery system based on angelica polysaccharide for liver cancer therapy	48
Preparation and use of nanogels as carriers of drugs	47
Self-assembled polymeric nanocarrier-mediated co-delivery of metformin and doxorubicin for melanoma therapy	45
Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis	45
Enrofloxacin/florfenicol loaded cyclodextrin metal-organic-framework for drug delivery and controlled release	42
Recent advances in cell membrane-camouflaged nanoparticles for inflammation therapy	41

Development of L-carnosine functionalized iron oxide nanoparticles loaded with dexamethasone for simultaneous therapeutic potential of blood brain barrier crossing and ischemic stroke treatment	38
Targeted treatment for osteoarthritis: drugs and delivery system	38
Self-emulsifying drug delivery systems: a novel approach to deliver drugs	38
Structural and biological investigation of chitosan/hyaluronic acid with silanized-hydroxypropyl methylcellulose as an injectable reinforced interpenetrating network hydrogel for cartilage tissue engi	38
Exosome loaded genipin crosslinked hydrogel facilitates full thickness cutaneous wound healing in rat animal model	38
Stimuli-responsive drug delivery systems for head and neck cancer therapy	37
Layer-by-Layer assembled nano-drug delivery systems for cancer treatment	35
Docetaxel-loaded exosomes for targeting non-small cell lung cancer: preparation and evaluation in vitro and in vivo	34
Hepatic stellate cell reprogramming via exosome-mediated CRISPR/dCas9-VP64 delivery	34
Topical delivery of l -ascorbic acid spanlastics for stability enhancement and treatment of UVB induced damaged skin	33
Enhancement of oral bioavailability of quercetin by metabolic inhibitory nanosuspensions compared to conventional nanosuspensions	31
Targeted delivery of quercetin by biotinylated mixed micelles for non-small cell lung cancer treatment	31
Dextran sulfate-based MMP-2 enzyme-sensitive SR-A receptor targeting nanomicelles for the treatment of rheumatoid arthritis	31
Nanodelivery of essential oils as efficient tools against antimicrobial resistance: a review of the type and physical-chemical properties of the delivery systems and applications	31
β-cyclodextrin chitosan-based hydrogels with tunable pH-responsive properties for controlled release of acyclovir: design, characterization, safety, and pharmacokinetic evaluation	31
Gemcitabine cationic polymeric nanoparticles against ovarian cancer: formulation, characterization, and targeted drug delivery	30
Thymoquinone-entrapped chitosan-modified nanoparticles: formulation optimization to preclinical bioavailability assessments	30
Extracellular vesicles: emerging anti-cancer drugs and advanced functionalization platforms for cancer therapy	30
Novel cubosome based system for ocular delivery of acetazolamide	30
Anti-lung cancer effect of paclitaxel solid lipid nanoparticles delivery system with curcumin as co-loading partner in vitro and in vivo	29
Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology	29
Sonodynamical reversion of immunosuppressive microenvironment in prostate cancer via engineered exosomes	29
A detailed insight of the tumor targeting using nanocarrier drug delivery system	28
Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke	28
Recent advances in anti-multidrug resistance for nano-drug delivery system	28
Novel chitosan and bacterial cellulose biocomposites tailored with polymeric nanoparticles for modern wound dressing development	28
Nanocrystals based pulmonary inhalation delivery system: advance and challenge	27
Combined and targeted drugs delivery system for colorectal cancer treatment: Conatumumab decorated, reactive oxygen species sensitive irinotecan prodrug and quercetin co-loaded nanostructured lipid ca	27
Statistical optimization of bile salt deployed nanovesicles as a potential platform for oral delivery of piperine: accentuated antiviral and anti-inflammatory activity in MERS-CoV challenged mice	27
Targeted therapy of rheumatoid arthritis via macrophage repolarization	27
Utilization of PEGylated cerosomes for effective topical delivery of fenticonazole nitrate: in-vitro characterization, statistical optimization, and in-vi	27
Manganese-containing polydopamine nanoparticles as theranostic agents for magnetic resonance imaging and photothermal/chemodynamic combined ferroptosis therapy treating gastric cancer	26
Recent progress in nanotechnology-based drug carriers for resveratrol delivery	26
Amplification of anticancer efficacy by co-delivery of doxorubicin and lonidamine with extracellular vesicles	26
From blood to brain: blood cell-based biomimetic drug delivery systems	26
Combination prostate cancer therapy: Prostate-specific membranes antigen targeted, pH-sensitive nanoparticles loaded with doxorubicin and tanshinone	26
Construction of pH-sensitive targeted micelle system co-delivery with curcumin and dasatinib and evaluation of anti-liver cancer	26
Electrospun multifunctional nanofibrous mats loaded with bioactive anemoside B4 for accelerated wound healing in diabetic mice	26
Cubogel as potential platform for glaucoma management	25
Polymeric versus lipid nanocapsules for miconazole nitrate enhanced topical delivery: in vitro and ex vivo evaluation	25
3D-printed implantable devices with biodegradable rate-controlling membrane for sustained delivery of hydrophobic drugs	25
Intranasal administration of dauricine loaded on graphene oxide: multi-target therapy for Alzheimer's disease	25
Development and optimization of curcumin analog nano-bilosomes using 21.31full factorial design for anti-tumor profiles improvement in human hepatocellular carcinoma:in-vitro<	25
Delivery of human natural killer cell-derived exosomes for liver cancer therapy: an in vivo study in subcutaneous and orthotopic animal models	25
Hybrid thermosensitive-mucoadhesive in situ forming gels for enhanced corneal wound healing effect of L-carnosine	24
Statistical optimization of hyaluronic acid enriched ultradeformable elastosomes for ocular delivery of voriconazole via Box-Behnken design: in vitro characterization an	24
An efficient enzyme-triggered controlled release system for colon-targeted oral delivery to combat dextran sodium sulfate (DSS)-induced colitis in mice	24
The optimized drug delivery systems of treating cancer bone metastatic osteolysis with nanomaterials	24
Development of omega-3 loxoprofen-loaded nanoemulsion to limit the side effect associated with NSAIDs in treatment of tooth pain	23
Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy	23

Icaritin-loaded PLGA nanoparticles activate immunogenic cell death and facilitate tumor recruitment in mice with gastric cancer	23
Synthesis of nanocapsules blended polymeric hydrogel loaded with bupivacaine drug delivery system for local anesthetics and pain management	23
Olive oil and clove oil-based nanoemulsion for topical delivery of terbinafine hydrochloride: in vitro and ex vivo evaluation	23
Aqueous core epigallocatechin gallate PLGA nanocapsules: characterization, antibacterial activity against uropathogens, and in vivo reno-protective effect in cisplatin induced nephrotoxicity	23
Folic acid-modified ROS-responsive nanoparticles encapsulating luteolin for targeted breast cancer treatment	23
Co-delivery of paclitaxel (PTX) and docosahexaenoic acid (DHA) by targeting lipid nanoemulsions for cancer therapy	22
Combined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells	22
Flexible nano-liposomes-based transdermal hydrogel for targeted delivery of dexamethasone for rheumatoid arthritis therapy	21
Platelets are highly efficient and efficacious carriers for tumor-targeted nano-drug delivery	21
Green synthesis of gold nanoparticles from Dendrobium officinale and its anticancer effect on liver cancer	21
Fabrication of silver nanoparticles/gelatin hydrogel system for bone regeneration and fracture treatment	21
Effect of pH-sensitive nanoparticles on inhibiting oral biofilms	21
Cepharanthine loaded nanoparticles coated with macrophage membranes for lung inflammation therapy	20
Brain targeting efficiency of intranasal clozapine-loaded mixed micelles following radio labeling with Technetium-99m	20
Nanophyto-gel against multi-drug resistant Pseudomonas aeruginosa burn wound infection	20
Pullulan based derivatives: synthesis, enhanced physicochemical properties, and applications	20
Monoclonal antibody as a targeting mediator for nanoparticle targeted delivery system for lung cancer	20
Luteolin-loaded exosomes derived from bone marrow mesenchymal stem cells: a promising therapy for liver fibrosis	20
Anti-inflammatory and antioxidant effects of nanoformulations composed of metal-organic frameworks delivering rutin and/or piperine natural agents	20
Low-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential	20
Nanocubosomal based in situ gel loaded with natamycin for ocular fungal diseases: development, optimization, in-vitro , and	20
Bioadhesive polymer/lipid hybrid nanoparticles as oral delivery system of raloxifene with enhancive intestinal retention and bioavailability	20
Hyaluronan-modified transfersomes based hydrogel for enhanced transdermal delivery of indomethacin	20
Model-based optimized steering and focusing of local magnetic particle concentrations for targeted drug delivery	19
PLGA sustained-release microspheres loaded with an insoluble small-molecule drug: microfluidic-based preparation, optimization, characterization, and evaluation in vitro and in vivo	19
Self-assembling peptides-based nano-cargos for targeted chemotherapy and immunotherapy of tumors: recent developments, challenges, and future perspectives	19
Merits and advances of microfluidics in the pharmaceutical field: design technologies and future prospects	19
Lipidic cubic-phase leflunomide nanoparticles (cubosomes) as a potential tool for breast cancer management	19
The Port Delivery System with ranibizumab: a new paradigm for long-acting retinal drug delivery	19
pH and ROS sequentially responsive podophyllotoxin prodrug micelles with surface charge-switchable and self-amplification drug release for combating multidrug resistance cancer	19
Alginate nanogels-based thermosensitive hydrogel to improve antidepressant-like effects of albiflorin via intranasal delivery	19
Management of recurrent aphthous ulcers exploiting polymer-based Muco-adhesive sponges : in-vitro and in-vivo evaluation	19
Targeted co-delivery biomimetic nanoparticles reverse macrophage polarization for enhanced rheumatoid arthritis therapy	19
Alginate-based aerogels as wound dressings for efficient bacterial capture and enhanced antibacterial photodynamic therapy	19
Functionalized chitosan nanoparticles for cutaneous delivery of a skin whitening agent: an approach to clinically augment the therapeutic efficacy for melasma treatment	18
Chitosan-modified hollow manganese dioxide nanoparticles loaded with resveratrol for the treatment of spinal cord injury	18
Nose-to-brain delivery of borneol modified tanshinone IIA nanoparticles in prevention of cerebral ischemia/reperfusion injury	18
Preparation and characterization of paclitaxel palmitate albumin nanoparticles with high loading efficacy: an in vitro and in vivo anti-tumor study in mouse models	18
Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer	18
Simulating drug penetration during hyperthermic intraperitoneal chemotherapy	18
Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction	18
Hydrogels for localized chemotherapy of liver cancer: a possible strategy for improved and safe liver cancer treatment	18
In vitro and in vivo evaluation of self-assembled chitosan nanoparticles selectively overcoming hepatocellular carcinoma via asialoglycoprotein recept	18
Ligand-modified homologous targeted cancer cell membrane biomimetic nanostructured lipid carriers for glioma therapy	18
Local drug delivery using poly(lactic-co-glycolic acid) nanoparticles in thermosensitive gels for inner ear disease treatment	18
Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment	18
Microbubble drug conjugate and focused ultrasound blood brain barrier delivery of AAV-2 SIRT-3	18
GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases	18
The most promising microneedle device: present and future of hyaluronic acid microneedle patch	17
Sorafenib-loaded nanostructured lipid carriers for topical ocular therapy of corneal neovascularization: development, in-vitro and in vivo study	17
Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis	17
Charge-reversal nanomedicine based on black phosphorus for the development of A Novel photothermal therapy of oral cancer	17
Design and optimization of cranberry extract loaded bile salt augmented liposomes for targeting of MCP-1/STAT3/VEGF signaling pathway in DMN-intoxicated liver in rats	17
Exosome mimetics derived from bone marrow mesenchymal stem cells deliver doxorubicin to osteosarcoma in vitro and in vivo	17
Development, optimization and characterization of nanoemulsion loaded with clove oil-naftifine antifungal for the management of tinea	17
Iodinated cyanine dye-based nanosystem for synergistic phototherapy and hypoxia-activated bioreductive therapy	17
Docetaxel loaded mPEG-PLA nanoparticles for sarcoma therapy: preparation, characterization, pharmacokinetics, and anti-tumor efficacy	17
Nanotechnological approach to delivering nutraceuticals as promising drug candidates for the treatment of atherosclerosis	17
Bone tumors effective therapy through functionalized hydrogels: current developments and future expectations	17
Improved anticancer activity of betulinic acid on breast cancer through a grafted copolymer-based micelles system	17
Multifunctional liposome for photoacoustic/ultrasound imaging-guided chemo/photothermal retinoblastoma therapy	17
Boosting curcumin activity against human prostatic cancer PC3 cells by utilizing scorpion venom conjugated phytosomes as promising functionalized nanovesicles	16
Corneal targeted fenticonazole nitrate-loaded novasomes for the management of ocular candidiasis: Preparation, in vitro characterization, ex vivo and in vivo assessments	16
D-optimal mixture design for optimization of topical dapsone niosomes: in vitro characterization and in vivo activity against Cutibacterium acnes	16
Silk fibroin hydrogel containing Sesbania sesban L. extract for rheumatoid arthritis treatment	16
Development of thermosensitive poloxamer 407-based microbubble gel with ultrasound mediation for inner ear drug delivery	16
RPE-derived exosomes rescue the photoreceptors during retina degeneration: an intraocular approach to deliver exosomes into the subretinal space	16
In vitro and in vivo antitumor effects of lupeol-loaded galactosylated liposomes	16
Selective delivery of curcumin to breast cancer cells by self-targeting apoferritin nanocages with pH-responsive and low toxicity	16
Oral gel loaded with penciclovir–lavender oil nanoemulsion to enhance bioavailability and alleviate pain associated with herpes labialis	16
Bilosomes as a promising nanoplatform for oral delivery of an alkaloid nutraceutical: improved pharmacokinetic profile and snowballed hypoglycemic effect in diabetic rats	15
Carbopol emulgel loaded with ebastine for urticaria: development, characterization, in vitro and in vivo evaluation	15
Development, optimization, and evaluation of a nanostructured lipid carrier of sesame oil loaded with miconazole for the treatment of oral candidiasis	15
Emerging strategies in nanotechnology to treat respiratory tract infections: realizing current trends for future clinical perspectives	15
Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective colon cancer therapy	15
Thermo-responsive injectable naringin-loaded hydrogel polymerised sodium alginate/bioglass delivery for articular cartilage	15
GSH-responsive poly-resveratrol based nanoparticles for effective drug delivery and reversing multidrug resistance	15
Ultrasound-sensitive siRNA-loaded nanobubbles fabrication and antagonism in drug resistance for NSCLC	15
Sonosensitizer nanoplatform-mediated sonodynamic therapy induced immunogenic cell death and tumor immune microenvironment variation	15
Star polyester-based folate acid-targeting nanoparticles for doxorubicin and curcumin co-delivery to combat multidrug-resistant breast cancer	15

Enhancing the in vitro and in vivo activity of itraconazole against breast cancer using miltefosine-modified lipid nanocapsules	15
Dasatinib self-assembled nanoparticles decorated with hyaluronic acid for targeted treatment of tumors to overcome multidrug resistance	15
Optimization of process parameters for fabrication of electrospun nanofibers containing neomycin sulfate and Malva sylvestris extract for a better diabetic wound healing	15
Stimuli-sensitive nano-drug delivery with programmable size changes to enhance accumulation of therapeutic agents in tumors	15
Celastrol-conjugated chitosan oligosaccharide for the treatment of pancreatic cancer	15
Anti-photoaging effects of flexible nanoliposomes encapsulated Moringa oleifera Lam. isothiocyanate in UVB-induced cell damage in HaCaT cells	15
A pH-responsive complex based on supramolecular organic framework for drug-resistant breast cancer therapy	15