OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 94. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-11-01 to 2025-11-01.)

Article	Citations
IgG sialylation puts lung inflammation to REST	1403
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	661
Something old, something new: The marriage of PD-1 and IL-2	583
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	564
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	547
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	508
Resident memory T cells call the shots in tissue immunity	464
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	405
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	356
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	328
The best offense is a good beta-defensin	326
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	277
Nerve-racking worms	276
Not so aDAMant after all: Plasticity of phagocytic microglia	274
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	266
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	266
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	265
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	260
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	258
The B7:CD28 family and friends: Unraveling coinhibitory interactions	251
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	243
Computationally designed proteins mimic antibody immune evasion in viral evolution	221
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	219
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	218
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	215

CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	214
Non-canonical IKKs side with N4BP1 against the family	210
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	198
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	188
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	184
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	179
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	178
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	171
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	168
The domiNO effect turns macrophage activation deadly	161
Plasmacytoid dendritic cells: Welcome back to the DC fold	161
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	158
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	158
TREMendous microglial effects on neurons	158
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	158
Genetics of autoinflammation instructs selective IL-1 targeting	149
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	148
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors	147
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	142
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	142
Sex hormone signaling and regulation of immune function	141
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	137
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	136
Mitochondria reactive oxygen species signaling in immune responses	136
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	135
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	134
CD8+ T cell tolerance: It doesn’t translate	133
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	132
An anti-aging vaccine: BCG turns back the clock on remyelination failure	129
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	128
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	126
ILC3s sense gut microbiota through STING to initiate immune tolerance	125
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	125
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	123
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	122
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	122
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	118
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	118
IL-33 is alarmin the uterus for labor	117
A universe of second messengers for cGLR-STING signaling	117
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	114
Gutcha: The microbiota drives tumor-induced mortality	114
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	113
Defining the landscape of human epidermal mononuclear phagocytes	113
Antigen-presenting cells as specialized drivers of intestinal T cell functions	112
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	112
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	111
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	111
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	111
Human determinants of age-dependent patterns of death from infection	111

Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	108
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	105
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	104
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	102
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	102
The conceptual foundations of innate immunity: Taking stock 30 years later	100
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	100
Gut instincts: Gasdermin D feeds while it fights	100
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	99
GATA4 as a maestro of gut regionalization	99
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	99
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	98
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	97
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina	97
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment	97
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	96
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation	96
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	95
Strength in diversity: Widening B cell recruitment for broader vaccine protection	94
Diverse priming outcomes under conditions of very rare precursor B cells	94
Are we there yet? An immune field trip through human embryonic development	94