OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 93. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-09-01 to 2025-09-01.)

Article	Citations
IgG sialylation puts lung inflammation to REST	1291
Something old, something new: The marriage of PD-1 and IL-2	618
Nerve-racking worms	537
Not so aDAMant after all: Plasticity of phagocytic microglia	518
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	502
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	494
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	468
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	431
Computationally designed proteins mimic antibody immune evasion in viral evolution	426
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	386
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	328
The best offense is a good beta-defensin	291
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	276
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	257
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	251
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	251
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	245
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	244
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	242
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	239
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	233
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	228
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	211
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	207
The B7:CD28 family and friends: Unraveling coinhibitory interactions	205

More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	203
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	200
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation	193
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	190
Mitochondria reactive oxygen species signaling in immune responses	187
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	179
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	172
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	170
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	168
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	167
Genetics of autoinflammation instructs selective IL-1 targeting	163
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	157
The domiNO effect turns macrophage activation deadly	157
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	155
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	154
Non-canonical IKKs side with N4BP1 against the family	150
TREMendous microglial effects on neurons	147
Plasmacytoid dendritic cells: Welcome back to the DC fold	145
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	143
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	140
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	140
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	139
A subset of Kupffer cells regulates metabolism through the expression of CD36	139
Sex hormone signaling and regulation of immune function	137
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming	133
CD8+ T cell tolerance: It doesn’t translate	133
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	130
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	127
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	127
Gutcha: The microbiota drives tumor-induced mortality	125
IL-33 is alarmin the uterus for labor	124
A universe of second messengers for cGLR-STING signaling	123
Defining the landscape of human epidermal mononuclear phagocytes	122
Human determinants of age-dependent patterns of death from infection	120
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	120
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	117
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	116
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	115
ILC3s sense gut microbiota through STING to initiate immune tolerance	115
An anti-aging vaccine: BCG turns back the clock on remyelination failure	113
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	112
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	112
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	112
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	111
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	110
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	110
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	109
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	108
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	106
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	106

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	106
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	105
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	105
The conceptual foundations of innate immunity: Taking stock 30 years later	104
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	103
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	103
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	103
Are we there yet? An immune field trip through human embryonic development	102
Antigen-presenting cells as specialized drivers of intestinal T cell functions	102
Sex-biased gut dopamine signaling in multiple sclerosis	101
“Bloody” good factors for keeping the brain young	101
Trade-offs inside the black box of neoantigen prediction	100
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	99
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	96
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response	95
Response to identifying the epidermal dendritic cell landscape	94
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages	94
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification	93