OOIR: Observatory of International Research

Papers

(The H4-Index of Immunity is 98. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-05-01 to 2026-05-01.)

Article	Citations
IgG sialylation puts lung inflammation to REST	777
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	662
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	505
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	458
Resident memory T cells call the shots in tissue immunity	422
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	393
Nerve-racking worms	392
Not so aDAMant after all: Plasticity of phagocytic microglia	372
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	368
Computationally designed proteins mimic antibody immune evasion in viral evolution	367
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	356
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry	313
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	312
Plasma cell ontogenies, functions, and lifespans	310
Universal vaccines? Only if your antibody genes agree	307
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	270
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils	263
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	258
The B7:CD28 family and friends: Unraveling coinhibitory interactions	255
Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading	246
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	244
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	244
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	240
The best offense is a good beta-defensin	233
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	233

Mechanisms of inflammatory bowel diseases: Insights from human genetics and chemical biology	226
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	219
Something old, something new: The marriage of PD-1 and IL-2	211
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	205
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	204
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	196
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	196
Targeting immune cells in the aged brain reveals that engineered cytokine IL-10 enhances neurogenesis and improves cognition	184
Glymphatics and meningeal lymphatics unlock the brain-immune code	181
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	172
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	171
Intestinal dysbiosis exacerbates skin inflammation via microbial metabolite-driven Th2 cell differentiation	170
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	163
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	162
Non-canonical IKKs side with N4BP1 against the family	160
Genetics of autoinflammation instructs selective IL-1 targeting	158
TREMendous microglial effects on neurons	158
Cystine fuels ILC2s to survive lung inflammation	157
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	156
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	155
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors	152
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	151
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	150
Homeostatic mature dendritic cells instruct fibroblast specialization via Notch2 signaling to establish T cell niches	149
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	147
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	145
Mitochondria reactive oxygen species signaling in immune responses	142
Sex hormone signaling and regulation of immune function	141
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	139
Antibody-mediated feedback modulates interclonal competition in the germinal center	139
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	138
CD8+ T cell tolerance: It doesn’t translate	133
Defining the landscape of human epidermal mononuclear phagocytes	131
IL-33 is alarmin the uterus for labor	128
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	128
Gutcha: The microbiota drives tumor-induced mortality	127
A universe of second messengers for cGLR-STING signaling	127
An anti-aging vaccine: BCG turns back the clock on remyelination failure	126
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	124
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	123
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	120
ILC3s sense gut microbiota through STING to initiate immune tolerance	120
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	119
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	119
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	118
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	117
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	117
Human determinants of age-dependent patterns of death from infection	117
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	117
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	116

Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	116
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	115
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	115
Training, memory, and tissue adaptation of NK cells and innate lymphoid cells	115
The conceptual foundations of innate immunity: Taking stock 30 years later	113
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	113
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	111
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	111
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	111
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	109
Antigen-presenting cells as specialized drivers of intestinal T cell functions	108
GATA4 as a maestro of gut regionalization	108
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	108
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	108
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	107
Strength in diversity: Widening B cell recruitment for broader vaccine protection	107
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	107
Are we there yet? An immune field trip through human embryonic development	105
Response to identifying the epidermal dendritic cell landscape	103
Sex-biased gut dopamine signaling in multiple sclerosis	101
“Bloody” good factors for keeping the brain young	101
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation	99
Trade-offs inside the black box of neoantigen prediction	99
Gut instincts: Gasdermin D feeds while it fights	98
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	98