Immunity

Article	Citations
IgG sialylation puts lung inflammation to REST	1291
Something old, something new: The marriage of PD-1 and IL-2	618
Nerve-racking worms	537
Not so aDAMant after all: Plasticity of phagocytic microglia	518
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	502
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	494
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	468
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	431
Computationally designed proteins mimic antibody immune evasion in viral evolution	426
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	386
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	328
The best offense is a good beta-defensin	291
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	276
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	257
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	251
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	251
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	245
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	244
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	242
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	239
A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	233
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	228
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	211
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	207
The B7:CD28 family and friends: Unraveling coinhibitory interactions	205

More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	203
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	200
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation	193
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	190
Mitochondria reactive oxygen species signaling in immune responses	187
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	179
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	172
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	170
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	168
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	167
Genetics of autoinflammation instructs selective IL-1 targeting	163
The domiNO effect turns macrophage activation deadly	157
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	157
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	155
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	154
Non-canonical IKKs side with N4BP1 against the family	150
TREMendous microglial effects on neurons	147
Plasmacytoid dendritic cells: Welcome back to the DC fold	145
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	143
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	140
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	140
A subset of Kupffer cells regulates metabolism through the expression of CD36	139
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	139
Sex hormone signaling and regulation of immune function	137
CD8+ T cell tolerance: It doesn’t translate	133
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming	133
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	130
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	127
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	127
Gutcha: The microbiota drives tumor-induced mortality	125
IL-33 is alarmin the uterus for labor	124
A universe of second messengers for cGLR-STING signaling	123
Defining the landscape of human epidermal mononuclear phagocytes	122
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	120
Human determinants of age-dependent patterns of death from infection	120
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	117
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	116
ILC3s sense gut microbiota through STING to initiate immune tolerance	115
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	115
An anti-aging vaccine: BCG turns back the clock on remyelination failure	113
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	112
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	112
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	112
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	111
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	110
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	110
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	109
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	108
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	106
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	106

Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	106
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	105
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	105
The conceptual foundations of innate immunity: Taking stock 30 years later	104
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	103
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	103
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	103
Antigen-presenting cells as specialized drivers of intestinal T cell functions	102
Are we there yet? An immune field trip through human embryonic development	102
“Bloody” good factors for keeping the brain young	101
Sex-biased gut dopamine signaling in multiple sclerosis	101
Trade-offs inside the black box of neoantigen prediction	100
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	99
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	96
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response	95
Response to identifying the epidermal dendritic cell landscape	94
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages	94
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification	93
GATA4 as a maestro of gut regionalization	92
Strength in diversity: Widening B cell recruitment for broader vaccine protection	92
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation	92
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	92
Antibodies and complement are key drivers of thrombosis	91
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity	91
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis	89
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina	89
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses	88
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection	88
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells	87
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation	87
Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination	87
Diverse priming outcomes under conditions of very rare precursor B cells	87
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	86
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	86
Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting	85
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity	85
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome	85
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	84
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells	84
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses	84
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation	84
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	83
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment	83
Meningeal macrophages protect against viral neuroinfection	83
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging	83
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway	83
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition	82
Good intentions gone wrong: The B cell block to epithelial repair	82
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B	82
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior	81
Innate-like memory T cells rapidly emerge in humans after gene therapy for SCID-X1	80
The immunology of stroke and dementia	80
Dimeric IgA specifically disables intracellular mutated oncodrivers	80
Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea	79
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence	79
How does lipid phosphatase 1 (LPP1) regulate antitumor CD8+ T cell activity?	79
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections	78
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance	77
Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse	77
Antibody modulation of B cell responses—Incorporating positive and negative feedback	76
Nucleotide-dependent conformational changes direct peptide export by the transporter associated with antigen processing	75
IL-17 receptor goes solo in autoimmune inflammation	75
Long-distance microbial mechanisms impacting cancer immunosurveillance	75
Glymphatics and meningeal lymphatics unlock the brain-immune code	75
Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation	72
Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing	71
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity	71
Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity	71
Fungus packs a punch in the gut	70
Making good of a tricky start: How IgE and mast cells manage a protective sway in food allergy	70
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion	70
Emerging roles of innate and adaptive immunity in Alzheimer’s disease	70
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death	70
Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity	70
Persistence is key: Refining immunotherapy response prediction	69
TKI resistance in brain metastasis: A CTLA4 state of mind	69
Older and wiser: The benefits to neonates of aged neutrophils	69
ADAR1 edits the SenZ and SenZ-ability of RNA	68
Fooling TLR4 to promote fungal virulence	68
“Are you gonna go my way?”—Decisions at the Tfh-B cell interface	66

Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair	66
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease	66
Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation	66
Succinate preserves CD8+ T cell fitness to augment antitumor immunity	66
A gut response: Modulating chemotherapy efficacy with microbial metabolites	66
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders	65
A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut	64
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies	64
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers	63
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350	63
Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses	63
Drugging inflammation: Easier NSAID than done	63
An in vitro platform supports generation of human innate lymphoid cells from CD34+ hematopoietic progenitors that recapitulate ex vivo identity	63
Personalized syringes offer hope for pancreatic cancer patients	63
Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity	62
Of tenants and nomads: The faces of memory T cells	62
DC-T cell power couples in rheumatoid arthritis joints	62
Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms	61
An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance	61
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies	61
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C	60
Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis	60
Host-microbial crosstalk relies on “tuft” love	59
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes	59
Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation	58
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation	58
Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes	58
The cancer-immunity cycle: Indication, genotype, and immunotype	57
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer	57
Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response	56
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells	56
Dendritic cells as shepherds of T cell immunity in cancer	56
Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters	56
Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells	56
Superficial ice and deep blaze: A defense strategy of the skin	55
Macrophages in the gut: Masters in multitasking	55
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification	55
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses	55
How does Epstein-Barr virus trigger MS?	54
IRF2 integrates inflammatory signals to balance T cell exhaustion	54
Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation	54
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	54
The microbiota control the neonatal WNT-ernet	54
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir	53
Inflammasome signaling in astrocytes modulates hippocampal plasticity	53
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration	53
Boundaries and integration between microbiota, the nervous system, and immunity	52
Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension	52
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism	52
Physiological functions of RIG-I-like receptors	52
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo	52
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains	52
Myeloid C-type lectin receptors in innate immune recognition	52
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer	52
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease	52
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus	52
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation	51
SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase	51
Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity	51
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	51
The Spleen in Local and Systemic Regulation of Immunity	51
Genetic variation in antigen presentation and cancer immunotherapy	50
Learning from the nexus of autoimmunity and cancer	50
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks	50
Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes	50
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases	49
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors	49
Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis	49
Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract	49
Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells	49
A high-resolution view of intra-tumoral B cell immunity	49
Immo-bile-izing CD8+ T cell anti-tumor immunity	48
Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis	48
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis	48
Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease	48
Skin deep: Epithelial cell metabolism and chronic skin inflammation	48
Next generation lysosome: Brought to you by cGAS-STING	48
OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity	48
Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells	48
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress	47
Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells	47
Tfh cells set the stage for tumor control	47
Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches	47
Deconstruction and reconstruction of lymphocytes for precision medicine	47
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers	47
Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance	47
Mitochondrial control of macrophage polarity in tumors	47
Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes	46
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network	46
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1	46
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling	46
Programmed and environmental determinants driving neonatal mucosal immune development	46
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells	46
DCs unchained: Whetting dendritic-cell appetite boosts wound healing	45
Decoding nociceptor-DC dialogues	45