Immunity

Article	Citations
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	1022
Microbiota translocation following intestinal barrier disruption promotes Mincle-mediated training of myeloid progenitors in the bone marrow	511
Nerve-racking worms	471
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease	445
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus	436
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	430
Laying the foundation for single-cell studies in bats	411
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	411
How does Epstein-Barr virus trigger MS?	404
IFN-γ(g)uarding the niche—Keeping ILC2 in check	395
Immunological imprinting shapes the specificity of human antibody responses against SARS-CoV-2 variants	393
Impaired development of memory B cells and antibody responses in humans and mice deficient in PD-1 signaling	353
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	335
The transcription factor MEF2C restrains microglial overactivation by inhibiting kinase CDK2	328
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs	304
IgG sialylation puts lung inflammation to REST	303
Response to Are NKT cells a useful predictor of COVID-19 severity?	283
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains	276
Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures	274
The Spleen in Local and Systemic Regulation of Immunity	262
Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma	260
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation	239
Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance	235
Long-lasting B cell convergence to distinct broadly reactive epitopes following vaccination with chimeric influenza virus hemagglutinins	219
The best offense is a good beta-defensin	212

Monocytes asphyxiate germinal centers	206
Navigating COVID-19: Starting a lab during the pandemic	206
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	205
Not so aDAMant after all: Plasticity of phagocytic microglia	203
Anti-vascular endothelial growth factor treatment potentiates immune checkpoint blockade through a BAFF- and IL-12-dependent reprogramming of the TME	202
Fate mapping of single NK cells identifies a type 1 innate lymphoid-like lineage that bridges innate and adaptive recognition of viral infection	201
Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity	198
Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis	180
IRF8 deficiency induces the transcriptional, functional, and epigenetic reprogramming of cDC1 into the cDC2 lineage	179
Contamination of isolated mouse Kupffer cells with liver sinusoidal endothelial cells	178
25-hydroxycholesterol: Gatekeeper of intestinal IgA	178
Superficial ice and deep blaze: A defense strategy of the skin	176
On blood and tissue-resident natural killer cells	173
Upper airway and brain protection by plasma cells: A local affair	172
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	171
Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation	167
NK resident memory cells arise from NK cells that accumulate in tissues independently of persistent local infection	165
BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses	160
Innate riddle of CD4+ T cells and the control of enteric infections	158
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	152
Home at last: Mixed signals guide memory T cells to residency	150
Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis	150
LAGging behind no more: PD-1 has a new immunotherapy partner	150
Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation	142
Brief homogeneous TCR signals instruct common iNKT progenitors whose effector diversification is characterized by subsequent cytokine signaling	140
The microbiota control the neonatal WNT-ernet	140
Not immune to stress: LBP’s link to depression	140
Methotrexate suppresses psoriatic skin inflammation by inhibiting muropeptide transporter SLC46A2 activity	135
IRF2 integrates inflammatory signals to balance T cell exhaustion	133
Exploring vast microbial epitope spaces	128
Metabolism in type 2 immune responses	127
Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint	126
A Fc engineering approach to define functional humoral correlates of immunity against Ebola virus	123
Ovarian tumors orchestrate distinct cellular compositions	122
The folate way to T cell fate	121
The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation	121
A no-Wnt situation for alveolar macrophage self-renewal	121
Many Langerhans make light work of skin immunity	119
It takes a village to skew a lymph node	119
Something old, something new: The marriage of PD-1 and IL-2	119
Single-cell analysis of memory B cells from top neutralizers reveals multiple sites of vulnerability within HCMV Trimer and Pentamer	115
Fragile-like regulatory T cells modulate opioid withdrawal in humans and mice	115
B cells! Don’t go the wrong way in this tumor	114
RIPK1: Inflamed if you do, inflamed if you don’t	114
A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance	113
The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation	113
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	111
Spheromers reveal robust T cell responses to the Pfizer/BioNTech vaccine and attenuated peripheral CD8+ T cell responses post SARS-CoV-2 infection	111
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	110
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir	110

Progressive polyadenylation and m6A modification of Ighg1 mRNA maintain IgG1 antibody homeostasis in antibody-secreting cells	109
A local subset of mesenchymal cells expressing the transcription factor Osr1 orchestrates lymph node initiation	108
CD1 and MR1: An update after a long-awaited reunion	107
SARS-CoV-2 Omicron BA.1 breakthrough infection drives late remodeling of the memory B cell repertoire in vaccinated individuals	106
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	102
Learning from the nexus of autoimmunity and cancer	102
Dopamine inhibits group 2 innate lymphoid cell-driven allergic lung inflammation by dampening mitochondrial activity	101
Analysis of antibody binding specificities in twin and SNP-genotyped cohorts reveals that antiviral antibody epitope selection is a heritable trait	101
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	99
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C	99
Cytotoxic Th1 cells mushroom after fungal exposures in Crohn’s disease	98
Retinoid X receptor gamma dictates the activation threshold of group 2 innate lymphoid cells and limits type 2 inflammation in the small intestine	97
Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes	96
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	95
PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis	95
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis	95
CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation	95
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells	94
SARS-CoV-2-specific T cells in the changing landscape of the COVID-19 pandemic	94
Pleiotropic consequences of metabolic stress for the major histocompatibility complex class II molecule antigen processing and presentation machinery	93
Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential	93
Epithelial colonization by gut dendritic cells promotes their functional diversification	92
A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants	92
Distinct immunological signatures discriminate severe COVID-19 from non-SARS-CoV-2-driven critical pneumonia	92
Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease	91
Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut	91
Oxidative phosphorylation selectively orchestrates tissue macrophage homeostasis	91
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	90
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification	90
Progenitors of distinct lineages shape the diversity of mature type 2 conventional dendritic cells	89
Physiological functions of RIG-I-like receptors	88
The B7:CD28 family and friends: Unraveling coinhibitory interactions	88
Single-cell immunology: Past, present, and future	88
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	87
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration	87
Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells	86
Epstein-Barr virus gp42 antibodies reveal sites of vulnerability for receptor binding and fusion to B cells	86
Prenatal interleukin 6 elevation increases glutamatergic synapse density and disrupts hippocampal connectivity in offspring	85
Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection	85
The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands	85
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses	84
Colony stimulating factor-1 producing endothelial cells and mesenchymal stromal cells maintain monocytes within a perivascular bone marrow niche	84
B cell receptor signaling in germinal centers prolongs survival and primes B cells for selection	83
Overlapping and distinct features of viral and allergen immunity in the human lung	83
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	82
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	82
Machine learning predictions of MHC-II specificities reveal alternative binding mode of class II epitopes	82
Live and let die: TB control by enhancing apoptosis	81
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	81
A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance	81
The transcription regulators ZNF750 and LSD1/KDM1A dampen inflammation on the skin’s surface by silencing pattern recognition receptors	81
Boundaries and integration between microbiota, the nervous system, and immunity	80
Immune dysregulation and autoreactivity correlate with disease severity in SARS-CoV-2-associated multisystem inflammatory syndrome in children	80
HIV rapidly targets a diverse pool of CD4+ T cells to establish productive and latent infections	80
Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains	79
Tertiary lymphoid structures and B cells: An intratumoral immunity cycle	78
Control of adaptive immunity by pattern recognition receptors	78
Single-cell multiomics reveals persistence of HIV-1 in expanded cytotoxic T cell clones	78
Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation	77
N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation	77
Single-cell atlas of endothelial and mural cells across primary and metastatic brain tumors	77
Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment	77
RNA vaccines: A transformational advance	77
Interleukin-4 downregulates transcription factor BCL6 to promote memory B cell selection in germinal centers	76
High recallability of memory B cells requires ZFP318-dependent transcriptional regulation of mitochondrial function	76
Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer	74
The CD94/NKG2A inhibitory receptor educates uterine NK cells to optimize pregnancy outcomes in humans and mice	74
Long-term tolerance to skin commensals is established neonatally through a specialized dendritic cell subgroup	73
The NLR family of innate immune and cell death sensors	72
Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity	71
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	71
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	71
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer	71
New frontiers in the cGAS-STING intracellular DNA-sensing pathway	70
GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair	70
Liver macrophages in health and disease	70
Deep spatial profiling of human COVID-19 brains reveals neuroinflammation with distinct microanatomical microglia-T-cell interactions	69
SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase	69
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism	69
Circulating NK cells establish tissue residency upon acute infection of skin and mediate accelerated effector responses to secondary infection	68

Hypoxia-inducible factor 2α promotes pathogenic polarization of stem-like Th2 cells via modulation of phospholipid metabolism	67
Myeloid C-type lectin receptors in innate immune recognition	67
Time will tell: The temporal code of immune threats	67
Chemokines and the immune response to cancer	67
Mechanotransduction via endothelial adhesion molecule CD31 initiates transmigration and reveals a role for VEGFR2 in diapedesis	66
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	66
Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity	66
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks	65
Immo-bile-izing CD8+ T cell anti-tumor immunity	65
Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses	65
SPeak to the heart	65
Vaccine adjuvants: Tailoring innate recognition to send the right message	64
A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells	63
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure	63
The carbonyl nucleobase adduct M3Ade is a potent antigen for adaptive polyclonal MR1-restricted T cells	63
Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract	63
Tfh cells set the stage for tumor control	63
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors	63
Hidradenitis suppurativa: TLSs take the center stage	63
CAR T cells in autoimmune disease: On the road to remission	62
Cognate antigen engagement induces HIV-1 expression in latently infected CD4+ T cells from people on long-term antiretroviral therapy	62
An autonomous activation of interleukin-17 receptor signaling sustains inflammation and promotes disease progression	61
OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity	61
A pan-family screen of nuclear receptors in immunocytes reveals ligand-dependent inflammasome control	61
When the levee of sympathetic outflow breaks	60
Hugh Robson MacDonald (1946–2023)	60
RIP(K)ing away immunotherapy resistance	60
Propionate primes the DC pump in neonates	60
Of mice, men, women, and cancer	60
AI and immunology	59
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	59
Next generation lysosome: Brought to you by cGAS-STING	59
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	58
Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells	58
Navigating the mutation maze: An oncogenic driver’s guide to macrophage reprogramming	57
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers	57
Breadth of Fc-mediated effector function correlates with clinical immunity following human malaria challenge	57
Distinct human Langerhans cell subsets orchestrate reciprocal functions and require different developmental regulation	57
Non-canonical IKKs side with N4BP1 against the family	56
Sensing DNA as danger: The discovery of cGAS	56
Of myeloid cells and fibroblasts—A love story	56
Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis	55
Autoantibodies inhibit Plasmodium falciparum growth and are associated with protection from clinical malaria	55
Collaboration between distinct SWI/SNF chromatin remodeling complexes directs enhancer selection and activation of macrophage inflammatory genes	55
A new superhero, the intraepithelial mast cell, joins the “Guardians of the Gut”	55
TREMendous microglial effects on neurons	55
Skin deep: Epithelial cell metabolism and chronic skin inflammation	55
TCR signaling promotes formation of an STS1-Cbl-b complex with pH-sensitive phosphatase activity that suppresses T cell function in acidic environments	55
Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng	55
Gums make IL-23, no professionals needed	55
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	54
Take my breath away: TAM-ing anti-cancer immunity in hypoxic niches	54
Plasmacytoid dendritic cells: Welcome back to the DC fold	54
The epigenomic matrix of tissue-specific immune memory	54
Leucine-tRNA-synthase-2-expressing B cells contribute to colorectal cancer immunoevasion	53
The pre-exposure SARS-CoV-2-specific T cell repertoire determines the quality of the immune response to vaccination	53
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair	53
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages	53
Innate immune training restores pro-reparative myeloid functions to promote remyelination in the aged central nervous system	53
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	53
Pathogen metabolite checkpoint: NHR on guard	52
Genetic variation in antigen presentation and cancer immunotherapy	52
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	52
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress	51
The ins and outs of innate and adaptive type 2 immunity	51
Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease	51
Targeting innate immune pathways for cancer immunotherapy	50
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation	50
SARS-CoV-2 in immunocompromised individuals	50
Accelerated COVID-19 vaccine development: milestones, lessons, and prospects	50
CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope cross-react with selective seasonal coronaviruses	50
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells	49
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	49
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge	49
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	48
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	48
Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy	48
Early IFN-α signatures and persistent dysfunction are distinguishing features of NK cells in severe COVID-19	48
Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease	48
Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development	47
Infectious and lifestyle modifiers of immunity and host resilience	47
Antigen and checkpoint receptor engagement recalibrates T cell receptor signal strength	47
Fibroblast tissue priming—not so nice to C you!	47
A triplex for intestinal protection: Neurons, microbes, and goblet cells	46
Cytokines drive prostate cancer lineage plasticity	46
Microglia C-lectin/selectin' neurons to eat	45
The domiNO effect turns macrophage activation deadly	45
Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens	45
Eating macrophages for a healthy anti-NASH meal	45
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation	45