Immunity

Article	Citations
IgG sialylation puts lung inflammation to REST	1516
Something old, something new: The marriage of PD-1 and IL-2	644
Resident memory T cells call the shots in tissue immunity	583
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	557
Not so aDAMant after all: Plasticity of phagocytic microglia	503
The best offense is a good beta-defensin	441
Nerve-racking worms	375
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	363
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	309
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	302
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	300
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	296
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	289
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	285
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	282
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	279
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	274
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	274
Computationally designed proteins mimic antibody immune evasion in viral evolution	269
Deep profiling of human T cells defines compartmentalized clones and phenotypic trajectories across blood and tonsils	251
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	236
The B7:CD28 family and friends: Unraveling coinhibitory interactions	228
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	224
FOXP3 expression depends on cell-type-specific cis-regulatory elements and transcription factor circuitry	211
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	206

A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis	200
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	196
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	194
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	191
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	186
The domiNO effect turns macrophage activation deadly	183
Genetics of autoinflammation instructs selective IL-1 targeting	174
TREMendous microglial effects on neurons	174
Non-canonical IKKs side with N4BP1 against the family	171
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	169
Plasmacytoid dendritic cells: Welcome back to the DC fold	167
Genomic copy-number variants drive apoptotic evasion underlying acquired resistance to immune checkpoint inhibitors	166
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	165
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	163
Mitochondria reactive oxygen species signaling in immune responses	157
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	155
Glymphatics and meningeal lymphatics unlock the brain-immune code	152
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	147
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	145
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	145
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	141
Sex hormone signaling and regulation of immune function	140
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	139
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	135
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	134
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	134
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	133
CD8+ T cell tolerance: It doesn’t translate	132
A universe of second messengers for cGLR-STING signaling	129
IL-33 is alarmin the uterus for labor	129
Gutcha: The microbiota drives tumor-induced mortality	129
Defining the landscape of human epidermal mononuclear phagocytes	129
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	128
An anti-aging vaccine: BCG turns back the clock on remyelination failure	125
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	124
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	122
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	121
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	121
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	119
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	118
ILC3s sense gut microbiota through STING to initiate immune tolerance	117
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	117
Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells	116
Human determinants of age-dependent patterns of death from infection	113
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	112
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	112
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	112
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	110
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	110
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	109

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	107
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	107
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	106
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	105
The conceptual foundations of innate immunity: Taking stock 30 years later	105
Antigen-presenting cells as specialized drivers of intestinal T cell functions	105
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	104
Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	103
Gut instincts: Gasdermin D feeds while it fights	102
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	102
GATA4 as a maestro of gut regionalization	101
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation	100
Are we there yet? An immune field trip through human embryonic development	99
Response to identifying the epidermal dendritic cell landscape	99
Strength in diversity: Widening B cell recruitment for broader vaccine protection	98
Sex-biased gut dopamine signaling in multiple sclerosis	97
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	96
Trade-offs inside the black box of neoantigen prediction	96
“Bloody” good factors for keeping the brain young	96
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment	95
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	95
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	94
Antibodies and complement are key drivers of thrombosis	94
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	94
Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting	93
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses	93
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification	93
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway	92
Diverse priming outcomes under conditions of very rare precursor B cells	92
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses	92
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	91
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	91
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging	90
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis	90
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity	89
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells	89
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection	88
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation	88
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages	87
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation	86
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	86
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina	86
Intra-tumoral hypoxia promotes CD8+ T cell dysfunction via chronic activation of integrated stress response transcription factor ATF4	86
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome	85
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells	85
Meningeal macrophages protect against viral neuroinfection	85
Making good of a tricky start: How IgE and mast cells manage a protective sway in food allergy	84
Good intentions gone wrong: The B cell block to epithelial repair	83
IL-17 receptor goes solo in autoimmune inflammation	83
Dimeric IgA specifically disables intracellular mutated oncodrivers	82
Fungus packs a punch in the gut	82
Nucleotide-dependent conformational changes direct peptide export by the transporter associated with antigen processing	80
How does lipid phosphatase 1 (LPP1) regulate antitumor CD8+ T cell activity?	80
Fermenting T cell stemness for cancer immunity	78
Innate-like memory T cells rapidly emerge in humans after gene therapy for SCID-X1	77
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition	77
Cryo-EM structure of endogenous Pfs230:Pfs48/45 complex with six antibodies reveals mechanisms of malaria transmission-blocking activity	77
Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse	77
Glymphatics and meningeal lymphatics unlock the brain-immune code	76
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior	76
Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea	76
Epigenetic silencing of interleukin-10 by host-derived oxidized phospholipids supports a lethal inflammatory response to infections	75
Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8+ T cell immunity against melanoma	75
TCR signaling via NFATc1 constrains IL-15-induced bystander activation of human memory CD8+ T cells	75
Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity	74
Long-distance microbial mechanisms impacting cancer immunosurveillance	74
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance	74
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death	73
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence	72
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity	72
Antibody modulation of B cell responses—Incorporating positive and negative feedback	71
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B	71
Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing	71
The immunology of stroke and dementia	71
Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity	70
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion	70
Drugging inflammation: Easier NSAID than done	69
Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation	69
Older and wiser: The benefits to neonates of aged neutrophils	69
Emerging roles of innate and adaptive immunity in Alzheimer’s disease	69

“Are you gonna go my way?”—Decisions at the Tfh-B cell interface	68
Of tenants and nomads: The faces of memory T cells	68
A gut response: Modulating chemotherapy efficacy with microbial metabolites	68
Persistence is key: Refining immunotherapy response prediction	67
Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms	67
Host-microbial crosstalk relies on “tuft” love	67
Personalized syringes offer hope for pancreatic cancer patients	67
An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance	66
Fooling TLR4 to promote fungal virulence	66
Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity	65
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies	65
Tame the Hydra’s head: Targeting bone marrow maladaptive myelopoiesis to reverse macrophage-mediated immunosuppression in cancer	65
Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis	64
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers	64
Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells	64
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders	64
TKI resistance in brain metastasis: A CTLA4 state of mind	63
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes	63
DC-T cell power couples in rheumatoid arthritis joints	63
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C	62
Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes	62
Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses	62
Spatially restricted and ontogenically distinct hepatic macrophages are required for tissue repair	62
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350	62
A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut	62
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies	62
Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation	60
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation	59
Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation	58
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells	58
Succinate preserves CD8+ T cell fitness to augment antitumor immunity	58
Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response	57
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease	57
Macrophages in the gut: Masters in multitasking	57
Dendritic cells as shepherds of T cell immunity in cancer	57
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer	57
Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes	56
The cancer-immunity cycle: Indication, genotype, and immunotype	56
How does Epstein-Barr virus trigger MS?	56
Alcaligenes faecalis induces intestinal T helper-17 cells by enhancing Rorc transcription through E3 ligase Trim21-mediated Fbxw7 degradation	56
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	56
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains	56
Superficial ice and deep blaze: A defense strategy of the skin	55
The microbiota control the neonatal WNT-ernet	55
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses	55
Learning from the nexus of autoimmunity and cancer	55
Microglia in the hypothalamic paraventricular nucleus sense hemodynamic disturbance and promote sympathetic excitation in hypertension	54
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation	54
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease	54
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus	54
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification	54
The Spleen in Local and Systemic Regulation of Immunity	54
Boundaries and integration between microbiota, the nervous system, and immunity	54
IRF2 integrates inflammatory signals to balance T cell exhaustion	54
Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions	54
SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase	54
Inflammasome signaling in astrocytes modulates hippocampal plasticity	54
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration	53
Myeloid C-type lectin receptors in innate immune recognition	53
Nociceptor-derived CGRP enhances dermal type I conventional dendritic cell function to drive autoreactive CD8+ T cell responses in vitiligo	53
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer	53
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	52
Physiological functions of RIG-I-like receptors	52
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir	52
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism	52
Approaches toward understanding human immunity	51
Immo-bile-izing CD8+ T cell anti-tumor immunity	51
Genetic variation in antigen presentation and cancer immunotherapy	51
Mitochondrial control of macrophage polarity in tumors	51
Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells	51
Deconstruction and reconstruction of lymphocytes for precision medicine	50
Skin deep: Epithelial cell metabolism and chronic skin inflammation	50
Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract	49
OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity	49
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers	49
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases	49
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors	49
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis	48
Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis	48
Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance	48
SARS-CoV-2 in immunocompromised individuals	47
A high-resolution view of intra-tumoral B cell immunity	47
Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells	47
Sensory neurons shape local macrophage identity via TGF-β signaling	47
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network	47
Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease	47
Next generation lysosome: Brought to you by cGAS-STING	47
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks	47
Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes	47