Immunity

Article	Citations
Nerve-racking worms	1120
IgG sialylation puts lung inflammation to REST	557
Something old, something new: The marriage of PD-1 and IL-2	477
Lymph node medulla regulates the spatiotemporal unfolding of resident dendritic cell networks	466
Particle uptake by macrophages triggers bifurcated transcriptional pathways that differentially regulate inflammation and lysosomal gene expression	460
Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming	444
Isolation of human antibodies against influenza B neuraminidase and mechanisms of protection at the airway interface	435
Releasing the brake: CTLA-4 loss turbocharges CAR T cells	423
Not so aDAMant after all: Plasticity of phagocytic microglia	416
A human antibody epitope map of Pfs230D1 derived from analysis of individuals vaccinated with a malaria transmission-blocking vaccine	394
Computationally designed proteins mimic antibody immune evasion in viral evolution	392
Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity	375
CD4+ T cells re-wire granuloma cellularity and regulatory networks to promote immunomodulation following Mtb reinfection	340
The best offense is a good beta-defensin	292
Intestinal microbiota controls graft-versus-host disease independent of donor-host genetic disparity	292
Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease	283
ARMH3-mediated recruitment of PI4KB directs Golgi-to-endosome trafficking and activation of the antiviral effector STING	281
IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis	251
Identification of an IL-1 receptor mutation driving autoinflammation directs IL-1-targeted drug design	245
Signals of pseudo-starvation unveil the amino acid transporter SLC7A11 as key determinant in the control of Treg cell proliferative potential	240
CD4+ T cell activation distinguishes response to anti-PD-L1+anti-CTLA4 therapy from anti-PD-L1 monotherapy	229
The B7:CD28 family and friends: Unraveling coinhibitory interactions	228
Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis	223
The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn’s disease	219
More than the sum: How vascular endothelial growth factor inhibition unlocks the full potential of immune checkpoint blockade	217

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression	217
COVID-19 vaccine mRNA-1273 elicits a protective immune profile in mice that is not associated with vaccine-enhanced disease upon SARS-CoV-2 challenge	216
Genetics of autoinflammation instructs selective IL-1 targeting	210
The domiNO effect turns macrophage activation deadly	200
Plasmacytoid dendritic cells: Welcome back to the DC fold	197
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations	196
The cholesterol metabolite 25-hydroxycholesterol restrains the transcriptional regulator SREBP2 and limits intestinal IgA plasma cell differentiation	193
Pyrimidine synthesis enzyme CTP synthetase 1 suppresses antiviral interferon induction by deamidating IRF3	191
Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis	183
Non-canonical IKKs side with N4BP1 against the family	181
HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery	180
TREMendous microglial effects on neurons	175
Immunoglobulin G-dependent inhibition of inflammatory bone remodeling requires pattern recognition receptor Dectin-1	174
Single-cell epigenetic, transcriptional, and protein profiling of latent and active HIV-1 reservoir revealed that IKZF3 promotes HIV-1 persistence	170
Uncoupling of macrophage inflammation from self-renewal modulates host recovery from respiratory viral infection	169
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids	167
Combined protein and nucleic acid imaging reveals virus-dependent B cell and macrophage immunosuppression of tissue microenvironments	162
Innate type 2 immunity controls hair follicle commensalism by Demodex mites	153
A subset of Kupffer cells regulates metabolism through the expression of CD36	150
Identification of a Kupffer cell subset capable of reverting the T cell dysfunction induced by hepatocellular priming	149
Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells	145
Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection	143
Disruption of the IL-33-ST2-AKT signaling axis impairs neurodevelopment by inhibiting microglial metabolic adaptation and phagocytic function	141
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation	138
Tfh-cell-derived interleukin 21 sustains effector CD8+ T cell responses during chronic viral infection	136
Activation of the transcription factor NRF2 mediates the anti-inflammatory properties of a subset of over-the-counter and prescription NSAIDs	134
Sex hormone signaling and regulation of immune function	131
An anti-aging vaccine: BCG turns back the clock on remyelination failure	130
T-Switch: A specificity-based engineering platform for developing safe and effective T cell therapeutics	130
CD8+ T cell tolerance: It doesn’t translate	129
Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses	128
A universe of second messengers for cGLR-STING signaling	126
Gutcha: The microbiota drives tumor-induced mortality	126
IL-33 is alarmin the uterus for labor	125
Antibiotic-driven dysbiosis in early life disrupts indole-3-propionic acid production and exacerbates allergic airway inflammation in adulthood	124
Defining the landscape of human epidermal mononuclear phagocytes	124
Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking	123
Pre-existing epigenetic state and differential NF-κB activation shape type 2 immune cell responses	123
Human determinants of age-dependent patterns of death from infection	122
ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP	120
Lack of affinity signature for germinal center cells that have initiated plasma cell differentiation	119
CXCL10 chemokine regulates heterogeneity of the CD8+ T cell response and viral set point during chronic infection	118
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates	117
Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230	116
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313	112
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis	109
Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease	109
A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection	108
Protective human monoclonal antibodies target conserved sites of vulnerability on the underside of influenza virus neuraminidase	106
Phage display sequencing reveals that genetic, environmental, and intrinsic factors influence variation of human antibody epitope repertoire	105

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway	105
The conceptual foundations of innate immunity: Taking stock 30 years later	105
Machine learning methods and harmonized datasets improve immunogenic neoantigen prediction	104
Antigen-presenting cells as specialized drivers of intestinal T cell functions	104
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis	104
Small intestinal resident eosinophils maintain gut homeostasis following microbial colonization	104
Membrane-bound mRNA immunogens lower the threshold to activate HIV Env V2 apex-directed broadly neutralizing B cell precursors in humanized mice	104
A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction	102
Response to identifying the epidermal dendritic cell landscape	101
Are we there yet? An immune field trip through human embryonic development	99
Bile acid receptor FXR promotes intestinal epithelial ferroptosis and subsequent ILC3 dysfunction in neonatal necrotizing enterocolitis	99
Sex-biased gut dopamine signaling in multiple sclerosis	99
“Bloody” good factors for keeping the brain young	99
TIL the end: Tracking T cell clonotype dynamics during adoptive cell therapy	98
Trade-offs inside the black box of neoantigen prediction	98
The effect of transient, constricted migration on neutrophil intracellular bacteria-killing capability	97
DNA methylation signatures reveal that distinct combinations of transcription factors specify human immune cell epigenetic identity	96
Diverse priming outcomes under conditions of very rare precursor B cells	96
High Amount of Transcription Factor IRF8 Engages AP1-IRF Composite Elements in Enhancers to Direct Type 1 Conventional Dendritic Cell Identity	95
DNA architectural protein CTCF facilitates subset-specific chromatin interactions to limit the formation of memory CD8+ T cells	95
Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses	94
Tissue factor binds to and inhibits interferon-α receptor 1 signaling	94
The polyamine-regulating enzyme SSAT1 impairs tissue regulatory T cell function in chronic cutaneous inflammation	93
Eliciting a single amino acid change by vaccination generates antibody protection against group 1 and group 2 influenza A viruses	93
Human anti-smallpox long-lived memory B cells are defined by dynamic interactions in the splenic niche and long-lasting germinal center imprinting	92
Antibodies from primary humoral responses modulate the recruitment of naive B cells during secondary responses	92
Antibodies and complement are key drivers of thrombosis	92
cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity	92
GATA4 as a maestro of gut regionalization	92
Strength in diversity: Widening B cell recruitment for broader vaccine protection	92
Recruitment of epitope-specific T cell clones with a low-avidity threshold supports efficacy against mutational escape upon re-infection	90
Splenic TNF-α signaling potentiates the innate-to-adaptive transition of antiviral NK cells	90
Classical monocyte ontogeny dictates their functions and fates as tissue macrophages	89
Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination	88
Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging	88
A CTCF-binding site in the Mdm1-Il22-Ifng locus shapes cytokine expression profiles and plays a critical role in early Th1 cell fate specification	88
Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation	87
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome	85
Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response	85
Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis	85
Mitochondrial DNA released by senescent tumor cells enhances PMN-MDSC-driven immunosuppression through the cGAS-STING pathway	85
Enhancer-driven gene regulatory networks reveal transcription factors governing T cell adaptation and differentiation in the tumor microenvironment	85
Meningeal macrophages protect against viral neuroinfection	84
Limited access to antigen drives generation of early B cell memory while restraining the plasmablast response	84
Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina	84
Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation	84
Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB−CD8+ memory T cells and accumulation of type 2 memory T cells	84
IL-17 receptor goes solo in autoimmune inflammation	83
Good intentions gone wrong: The B cell block to epithelial repair	83
Making good of a tricky start: How IgE and mast cells manage a protective sway in food allergy	82
The immunology of stroke and dementia	80
Epstein-Barr virus gH/gL has multiple sites of vulnerability for virus neutralization and fusion inhibition	79
Antigen presentation by tumor-associated macrophages drives T cells from a progenitor exhaustion state to terminal exhaustion	79
Fungus packs a punch in the gut	79
Elevated IL-22 as a result of stress-induced gut leakage suppresses septal neuron activation to ameliorate anxiety-like behavior	79
Temporal maturation of neutralizing antibodies in COVID-19 convalescent individuals improves potency and breadth to circulating SARS-CoV-2 variants	78
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity	78
Single-cell transcriptome analysis of the in vivo response to viral infection in the cave nectar bat Eonycteris spelaea	77
Emerging roles of innate and adaptive immunity in Alzheimer’s disease	76
The unique biology of germinal center B cells	76
Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity	76
Dimeric IgA specifically disables intracellular mutated oncodrivers	75
Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B	75
A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death	75
Glymphatics and meningeal lymphatics unlock the brain-immune code	74
Microenvironment-driven metabolic adaptations guiding CD8+ T cell anti-tumor immunity	73
Role of MR1-driven signals and amphiregulin on the recruitment and repair function of MAIT cells during skin wound healing	73
Long-distance microbial mechanisms impacting cancer immunosurveillance	73
Tuft cell-derived acetylcholine promotes epithelial chloride secretion and intestinal helminth clearance	73
Deep profiling deconstructs features associated with memory CD8+ T cell tissue residence	73
TKI resistance in brain metastasis: A CTLA4 state of mind	72
Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation	72
Host-microbial crosstalk relies on “tuft” love	72
Antibody modulation of B cell responses—Incorporating positive and negative feedback	72
Of tenants and nomads: The faces of memory T cells	71
Persistence is key: Refining immunotherapy response prediction	71
Older and wiser: The benefits to neonates of aged neutrophils	71
Fooling TLR4 to promote fungal virulence	70
ADAR1 edits the SenZ and SenZ-ability of RNA	70
A gut response: Modulating chemotherapy efficacy with microbial metabolites	70

“Are you gonna go my way?”—Decisions at the Tfh-B cell interface	70
Phase separation of chimeric antigen receptor promotes immunological synapse maturation and persistent cytotoxicity	69
Guard proteins keep watch at epithelial walls	69
An in vitro platform supports generation of human innate lymphoid cells from CD34+ hematopoietic progenitors that recapitulate ex vivo identity	69
DC-T cell power couples in rheumatoid arthritis joints	69
Structural basis for complement receptor engagement and virus neutralization through Epstein-Barr virus gp350	69
Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells	69
An embarrassment of riches: RORγt+ antigen-presenting cells in peripheral tolerance	68
A self-sustaining layer of early-life-origin B cells drives steady-state IgA responses in the adult gut	68
Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C	68
Drugging inflammation: Easier NSAID than done	67
The brain microvasculature is a primary mediator of interferon-α neurotoxicity in human cerebral interferonopathies	67
Microglial TMEM119 binds to amyloid-β to promote its clearance in an Aβ-depositing mouse model of Alzheimer’s disease	66
Plasmacytoid dendritic cell activation is dependent on coordinated expression of distinct amino acid transporters	66
Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms	66
CD4+ T cells reactive to a hybrid peptide from insulin-chromogranin A adopt a distinct effector fate and are pathogenic in autoimmune diabetes	66
Phage display of environmental protein toxins and virulence factors reveals the prevalence, persistence, and genetics of antibody responses	65
Personalized syringes offer hope for pancreatic cancer patients	65
Repression of the aryl-hydrocarbon receptor prevents oxidative stress and ferroptosis of intestinal intraepithelial lymphocytes	64
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies	64
LAG-3, TIM-3, and TIGIT: Distinct functions in immune regulation	64
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer	63
Dendritic cells as shepherds of T cell immunity in cancer	63
The cancer-immunity cycle: Indication, genotype, and immunotype	63
Primary germinal center-resident T follicular helper cells are a physiologically distinct subset of CXCR5hiPD-1hi T follicular helper cells	62
Obesity-induced dysregulation of skin-resident PPARγ+ Treg cells promotes IL-17A-mediated psoriatic inflammation	62
Circulating senescent myeloid cells infiltrate the brain and cause neurodegeneration in histiocytic disorders	62
Single-cell functional genomics reveals determinants of sensitivity and resistance to natural killer cells in blood cancers	62
Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis	61
Spatial maps of T cell receptors and transcriptomes reveal distinct immune niches and interactions in the adaptive immune response	61
Macrophages in the gut: Masters in multitasking	60
Superficial ice and deep blaze: A defense strategy of the skin	60
A triad of somatic mutagenesis converges in self-reactive B cells to cause a virus-induced autoimmune disease	60
How does Epstein-Barr virus trigger MS?	60
A. faecalis induces intestinal T helper 17 cells by promoting E3 ubiquitin ligase Trim21-mediated E3 ubiquitin ligase Fbxw7 degradation	59
The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation	59
The microbiota control the neonatal WNT-ernet	58
Inflammasome signaling in astrocytes modulates hippocampal plasticity	58
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism	57
Myeloid C-type lectin receptors in innate immune recognition	57
GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair	57
Autoimmune CD4+ T cells fine-tune TCF1 expression to maintain function and survive persistent antigen exposure during diabetes	57
Vaccination with a structure-based stabilized version of malarial antigen Pfs48/45 elicits ultra-potent transmission-blocking antibody responses	57
Microglial lipid phosphatase SHIP1 limits complement-mediated synaptic pruning in the healthy developing hippocampus	57
Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection	56
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification	56
SARS-CoV-2-infection- and vaccine-induced antibody responses are long lasting with an initial waning phase followed by a stabilization phase	56
Dysregulated lung stroma drives emphysema exacerbation by potentiating resident lymphocytes to suppress an epithelial stem cell reservoir	55
Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity	55
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	55
TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration	54
IRF2 integrates inflammatory signals to balance T cell exhaustion	54
Physiological functions of RIG-I-like receptors	52
Boundaries and integration between microbiota, the nervous system, and immunity	52
The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer	52
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colon	52
An exhausted-like microglial population accumulates in aged and APOE4 genotype Alzheimer’s brains	52
Learning from the nexus of autoimmunity and cancer	52
The Spleen in Local and Systemic Regulation of Immunity	51
Mural cell-derived chemokines provide a protective niche to safeguard vascular macrophages and limit chronic inflammation	51
Tfh cells set the stage for tumor control	51
Genetic variation in antigen presentation and cancer immunotherapy	51
Immo-bile-izing CD8+ T cell anti-tumor immunity	50
Next generation lysosome: Brought to you by cGAS-STING	50
Small intestine and colon tissue-resident memory CD8+ T cells exhibit molecular heterogeneity and differential dependence on Eomes	49
A high-resolution view of intra-tumoral B cell immunity	49
OAS cross-activates RNase L intercellularly through cell-to-cell transfer of 2-5A to spread innate immunity	48
Antigen-level resolution of commensal-specific B cell responses can be enabled by phage display screening coupled with B cell tetramers	48
Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract	47
Clonal multi-omics reveals Bcor as a negative regulator of emergency dendritic cell development	47
Skin deep: Epithelial cell metabolism and chronic skin inflammation	47
SARS-CoV-2 in immunocompromised individuals	47
Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches	46
Selective loss of resident macrophage-derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress	46
Programmed and environmental determinants driving neonatal mucosal immune development	46
Stress induces behavioral abnormalities by increasing expression of phagocytic receptor MERTK in astrocytes to promote synapse phagocytosis	46
Instructing durable humoral immunity for COVID-19 and other vaccinable diseases	46
Metallophilic marginal zone macrophages cross-prime CD8+ T cell-mediated protective immunity against blood-borne tumors	45
Deletion of the inhibitory co-receptor CTLA-4 enhances and invigorates chimeric antigen receptor T cells	45
Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells	45
Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks	45
Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling	45
Immunomodulatory leptin receptor+ sympathetic perineurial barrier cells protect against obesity by facilitating brown adipose tissue thermogenesis	45
Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis	45
Sialylated IgG induces the transcription factor REST in alveolar macrophages to protect against lung inflammation and severe influenza disease	45
Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1	45
Going viral: HBV-specific CD8+ tissue-resident memory T cells propagate anti-tumor immunity	44
Neighbor’s feedback helps macrophages learn tolerance in the gut	44
Standing on the shoulders of mice	44
Decoding nociceptor-DC dialogues	44
IKKβ primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network	44
Non-terminally exhausted tumor-resident memory HBV-specific T cell responses correlate with relapse-free survival in hepatocellular carcinoma	44
Maternal gut bacteria drive intestinal inflammation in offspring with neurodevelopmental disorders by altering the chromatin landscape of CD4+ T cells	44
Candida albicans elicits protective allergic responses via platelet mediated T helper 2 and T helper 17 cell polarization	44
DCs unchained: Whetting dendritic-cell appetite boosts wound healing	44