OOIR: Observatory of International Research

Papers

(The TQCC of Molecular Medicine is 17. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2020-04-01 to 2024-04-01.)

Article	Citations
IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19	191
Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?	165
Pirfenidone alleviates pulmonary fibrosis in vitro and in vivo through regulating Wnt/GSK-3β/β-catenin and TGF-β1/Smad2/3 signaling pathways	68
ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy	67
Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation	63
The role of the microbiome in ovarian cancer: mechanistic insights into oncobiosis and to bacterial metabolite signaling	60
Hydrogen peroxide and disease: towards a unified system of pathogenesis and therapeutics	59
Nebulized in-line endotracheal dornase alfa and albuterol administered to mechanically ventilated COVID-19 patients: a case series	57
CircRNAs and their regulatory roles in cancers	54
Novel targeted therapies for Parkinson’s disease	54
Key role of MIF-related neuroinflammation in neurodegeneration and cognitive impairment in Alzheimer’s disease	46
The roles of the gut microbiota–miRNA interaction in the host pathophysiology	45
METTL14 promotes glomerular endothelial cell injury and diabetic nephropathy via m6A modification of α-klotho	45
Human umbilical cord mesenchymal stem cells deliver exogenous miR-26a-5p via exosomes to inhibit nucleus pulposus cell pyroptosis through METTL14/NLRP3	43
LncRNA-Fendrr protects against the ubiquitination and degradation of NLRC4 protein through HERC2 to regulate the pyroptosis of microglia	42
Erythropoietin as candidate for supportive treatment of severe COVID-19	42
The cholinergic anti-inflammatory pathway alleviates acute lung injury	42
LINC00242/miR-1-3p/G6PD axis regulates Warburg effect and affects gastric cancer proliferation and apoptosis	41
Glabridin, a bioactive component of licorice, ameliorates diabetic nephropathy by regulating ferroptosis and the VEGF/Akt/ERK pathways	40
CXCL10 levels at hospital admission predict COVID-19 outcome: hierarchical assessment of 53 putative inflammatory biomarkers in an observational study	40
Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis	40
Escape from X chromosome inactivation and female bias of autoimmune diseases	39
The pyroptosis-related gene signature predicts prognosis and indicates immune activity in hepatocellular carcinoma	37
Syndecan-1, an indicator of endothelial glycocalyx degradation, predicts outcome of patients admitted to an ICU with COVID-19	35
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism	35

Exosomal miR-223 derived from natural killer cells inhibits hepatic stellate cell activation by suppressing autophagy	35
The significance of m6A RNA methylation regulators in predicting the prognosis and clinical course of HBV-related hepatocellular carcinoma	34
Danshensu inhibits the IL-1β-induced inflammatory response in chondrocytes and osteoarthritis possibly via suppressing NF-κB signaling pathway	34
Breast cancer cell-derived extracellular vesicles transfer miR-182-5p and promote breast carcinogenesis via the CMTM7/EGFR/AKT axis	34
ADSCs enhance VEGFR3-mediated lymphangiogenesis via METTL3-mediated VEGF-C m6A modification to improve wound healing of diabetic foot ulcers	34
Acupuncture protects against cerebral ischemia–reperfusion injury via suppressing endoplasmic reticulum stress-mediated autophagy and apoptosis	33
Essential properties and pitfalls of colorimetric Reverse Transcription Loop-mediated Isothermal Amplification as a point-of-care test for SARS-CoV-2 diagnosis	33
Long non-coding RNA H19, a novel therapeutic target for pancreatic cancer	33
MSCs‑derived exosomes attenuate ischemia-reperfusion brain injury and inhibit microglia apoptosis might via exosomal miR-26a-5p mediated suppression of CDK6	32
Subunits of ARID1 serve as novel biomarkers for the sensitivity to immune checkpoint inhibitors and prognosis of advanced non-small cell lung cancer	31
LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy	31
Taxonomic variations in the gut microbiome of gout patients with and without tophi might have a functional impact on urate metabolism	31
The crosstalk of ABCA1 and ANXA1: a potential mechanism for protection against atherosclerosis	30
lncRNA SNHG1 induced by SP1 regulates bone remodeling and angiogenesis via sponging miR-181c-5p and modulating SFRP1/Wnt signaling pathway	30
Antibody development for preventing the human respiratory syncytial virus pathology	30
Diagnostic and prognostic impact of cytokeratin 18 expression in human tumors: a tissue microarray study on 11,952 tumors	30
Pinocembrin mitigates depressive-like behaviors induced by chronic unpredictable mild stress through ameliorating neuroinflammation and apoptosis	29
The α7 nicotinic acetylcholine receptor agonist, GTS-21, attenuates hyperoxia-induced acute inflammatory lung injury by alleviating the accumulation of HMGB1 in the airways and the circulation	29
The emerging role of exosomal miRNAs as a diagnostic and therapeutic biomarker in Mycobacterium tuberculosis infection	29
Electroacupuncture alleviates polycystic ovary syndrome-like symptoms through improving insulin resistance, mitochondrial dysfunction, and endoplasmic reticulum stress via enhancing autophagy in rats	29
G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1	29
RETRACTED ARTICLE: microRNA-195 attenuates neuronal apoptosis in rats with ischemic stroke through inhibiting KLF5-mediated activation of the JNK signaling pathway	28
Ethyl pyruvate protects against sepsis-associated encephalopathy through inhibiting the NLRP3 inflammasome	27
Gut microbiota-testis axis: FMT improves systemic and testicular micro-environment to increase semen quality in type 1 diabetes	27
New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases	27
Macrophages and cancer stem cells: a malevolent alliance	26
FGF1 alleviates LPS-induced acute lung injury via suppression of inflammation and oxidative stress	26
Long noncoding RNA HCG18 inhibits the differentiation of human bone marrow-derived mesenchymal stem cells in osteoporosis by targeting miR-30a-5p/NOTCH1 axis	26
Everolimus regulates the activity of gemcitabine-resistant pancreatic cancer cells by targeting the Warburg effect via PI3K/AKT/mTOR signaling	26
Long non-coding RNA H19 in atherosclerosis: what role?	26
The involvement of neuroimmune cells in adipose innervation	26
Combined miRNA and SERS urine liquid biopsy for the point-of-care diagnosis and molecular stratification of bladder cancer	26
Redox modifications of cysteine residues regulate the cytokine activity of HMGB1	25
The role of host defences in Covid 19 and treatments thereof	25
Pinocembrin ameliorates post-infarct heart failure through activation of Nrf2/HO-1 signaling pathway	25
PTEN inhibitor improves vascular remodeling and cardiac function after myocardial infarction through PI3k/Akt/VEGF signaling pathway	24
CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis	24
Clinical implications for dopaminergic and functional neuroimage research in cognitive symptoms of Parkinson’s disease	24
Genotype-driven therapeutic developments in Parkinson’s disease	24
Silencing long non-coding RNA XIST suppresses drug resistance in acute myeloid leukemia through down-regulation of MYC by elevating microRNA-29a expression	23
circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling	23
Long non-coding RNA profile study identifies a metabolism-related signature for colorectal cancer	22
Knockdown of circROBO2 attenuates acute myocardial infarction through regulating the miR-1184/TRADD axis	22
Association of uncoupling protein (Ucp) gene polymorphisms with cardiometabolic diseases	21
Posttranslational modification and beyond: interplay between histone deacetylase 6 and heat-shock protein 90	21
microRNA-199a-5p regulates epithelial-to-mesenchymal transition in diabetic cataract by targeting SP1 gene	21
Circuit imaging biomarkers in preclinical and prodromal Parkinson's disease	21
The antioxidant N-acetylcysteine promotes immune response and inhibits epithelial-mesenchymal transition to alleviate pulmonary fibrosis in chronic obstructive pulmonary disease by suppressing the VWF	21
MiR-543 promotes tumorigenesis and angiogenesis in non-small cell lung cancer via modulating metastasis associated protein 1	21
LncRNA XIST upregulates TRIM25 via negatively regulating miR-192 in hepatitis B virus-related hepatocellular carcinoma	21

Quercetin mitigates rheumatoid arthritis by inhibiting adenosine deaminase in rats	20
The long noncoding RNA MEG3 regulates Ras-MAPK pathway through RASA1 in trophoblast and is associated with unexplained recurrent spontaneous abortion	20
Oxalate-induced apoptosis through ERS-ROS–NF-κB signalling pathway in renal tubular epithelial cell	20
Long non-coding RNA XIST: a novel oncogene in multiple cancers	20
Role of long non-coding RNA H19 in the development of osteoporosis	20
Osteogenesis of adipose-derived stem cells from patients with glucose metabolism disorders	20
The liver in sepsis: molecular mechanism of liver failure and their potential for clinical translation	20
Long non-coding RNA CIR inhibits chondrogenic differentiation of mesenchymal stem cells by epigenetically suppressing ATOH8 via methyltransferase EZH2	20
Increased H3K4me3 methylation and decreased miR-7113-5p expression lead to enhanced Wnt/β-catenin signaling in immune cells from PTSD patients leading to inflammatory phenotype	19
Exosomal miR-335 derived from mature dendritic cells enhanced mesenchymal stem cell-mediated bone regeneration of bone defects in athymic rats	19
TGF-β-induced α-SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells	19
MiR-206 regulates the Th17/Treg ratio during osteoarthritis	19
MiR-125b inhibits cardiomyocyte apoptosis by targeting BAK1 in heart failure	19
Baicalin alleviates chronic obstructive pulmonary disease through regulation of HSP72-mediated JNK pathway	19
Immunometabolism in biofilm infection: lessons from cancer	18
MAIT cell compartment characteristics are associated with the immune response magnitude to the BNT162b2 mRNA anti-SARS-CoV-2 vaccine	18
Calcitriol confers neuroprotective effects in traumatic brain injury by activating Nrf2 signaling through an autophagy-mediated mechanism	18
Meta-analysis of metabolites involved in bioenergetic pathways reveals a pseudohypoxic state in Down syndrome	18
Shikonin suppresses NEAT1 and Akt signaling in treating paclitaxel-resistant non-small cell of lung cancer	18
Cancer-associated fibroblasts impact the clinical outcome and treatment response in colorectal cancer via immune system modulation: a comprehensive genome-wide analysis	18
Role of long non-coding RNA H19 in therapy resistance of digestive system cancers	18
The SP1-12LOX axis promotes chemoresistance and metastasis of ovarian cancer	18
Maresin 1 protects the liver against ischemia/reperfusion injury via the ALXR/Akt signaling pathway	18
NK cell frequencies, function and correlates to vaccine outcome in BNT162b2 mRNA anti-SARS-CoV-2 vaccinated healthy and immunocompromised individuals	18
Does activation of the protective Renin-Angiotensin System have therapeutic potential in COVID-19?	18
FZD7 accelerates hepatic metastases in pancreatic cancer by strengthening EMT and stemness associated with TGF-β/SMAD3 signaling	17
Increased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus	17
LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation	17
Aerobic exercise improves VCI through circRIMS2/miR-186/BDNF-mediated neuronal apoptosis	17
Fibroblast growth factor-2 alleviates the capillary leakage and inflammation in sepsis	17
Identification and prognostic analysis of biomarkers to predict the progression of pancreatic cancer patients	17
TFPI2 suppresses breast cancer progression through inhibiting TWIST-integrin α5 pathway	17
Estrogen-related receptors: novel potential regulators of osteoarthritis pathogenesis	17
Relationship between brain iron deposition and mitochondrial dysfunction in idiopathic Parkinson’s disease	17
CB2-mediated attenuation of nucleus pulposus degeneration via the amelioration of inflammation and oxidative stress in vivo and in vitro	17