Nature Medicine

Article	Citations
Questionable role of new techniques in IVF embryo culture	2179
A genetic test to predict adverse drug reactions	1798
LLMs get a medical education	1588
Liquid biopsies and tumor mutational burden: the cutoff conundrum	845
In vivo gene editing for inherited vision loss	761
Recapitulating sensory feedback in artificial skin	748
Telemonitoring for complicated pregnancies	718
Rise in ambient temperature is associated with increased mortality in Latin America	692
Easing the pain of endometriosis	623
SCOTUS v. reproductive health in United States	623
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	610
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	605
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	587
Can an implanted minipump deliver for diabetes patients?	549
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	547
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	540
The inconvenient reality of AI-assisted embryo selection in IVF	534
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	504
Combating vaccine revisionism	499
A global metric of immune health	487
HIV prevention through PrEP in cisgender women	486
An AI chatbot for talking therapy referrals	478
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	475
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	444
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	432

Integrating the environmental and genetic architectures of aging and mortality	429
The WHO genomics program of work for equitable implementation of human genomics for global health	423
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	417
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	400
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	398
An explainable foundation model for drug repurposing	395
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	390
First tumor-agnostic approval for an ADC	389
Continuous glucose monitoring and intrapersonal variability in fasting glucose	389
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	381
The effect of geopolitical flux on antimicrobial resistance	379
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial	375
Ending the taboo on periods and period problems	374
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	373
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	371
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	370
How virtual reality therapy is shaping mental health	368
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	367
Estimating the total effect of anthropogenic climate change on human health and wellbeing	365
Concerns about the Burden of Proof studies	363
PD-L1 and the dawn of modern cancer immunotherapy	358
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	356
Supported decision-making can advance clinical research participation for people with disabilities	349
Gene-edited pig liver successfully transplanted into human	346
Author Correction: Digital consults in heart failure care: a randomized controlled trial	345
FDA approves first drug to delay type 1 diabetes	341
Author Correction: Unexplained post-acute infection syndromes	340
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	337
In utero origin of myelofibrosis presenting in adult monozygotic twins	335
AI as a new paradigm for risk-based screening for breast cancer	333
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	332
The capacity of brain circuits to enhance psychiatry	327
The role of research in China’s successful elimination of malaria	326
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	324
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	321
HIPAA is a misunderstood and inadequate tool for protecting medical data	319
Targeted therapy for osteoarthritis: progress and pitfalls	314
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	310
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	310
Solving medicine’s data bottleneck: Nightingale Open Science	310
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	304
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	302
The uncertain science of preimplantation and prenatal genetic testing	298
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	296
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	293
Will ChatGPT transform healthcare?	293
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	289
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	286
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	283
Integrated image-based deep learning and language models for primary diabetes care	283

IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	280
The landscape of mRNA nanomedicine	277
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	277
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	276
Hippocampal network activity forecasts epileptic seizures	276
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	274
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	273
Health in the Amazon	273
Rethinking aspirin for heart health	271
An outdated loophole is letting faulty lab tests hit the market	270
An anti-obesity drug from the diabetes toolbox	269
WHO sets research agenda for refugee and migrant health	265
The Yearbook	261
Mapping the cellular landscape of the brain	259
How patient advocates influence health policy	258
Menstrual health without stigma	257
Using genetics to predict toxicity of cancer immunotherapy	257
Brain pathology of COVID-19	257
The effect of embryonic genome imbalances on pregnancy	257
Air pollution interventions for health	253
Microbes convert plastic waste into paracetamol	253
An international treaty to regulate misuse of alcohol and cannabis	253
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	250
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	247
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	247
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	242
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	240
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	239
Health benefits of calorie restriction	237
A gene-by-sex interaction contributes to liver disease susceptibility in women	237
An African One Health network for antimicrobial resistance and neglected tropical diseases	236
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	235
Steps to prevent and respond to an H5N1 epidemic in the USA	234
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	233
The visible and hidden mortality caused by flooding	233
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	230
siRNA therapy lowers triglycerides in patients with rare condition	230
Prenatal exposure to famine affects lifelong health	227
Machine learning improves prediction of clinical outcomes for invasive breast cancers	225
Coproducing health research with Indigenous peoples	223
Meningioma risk stratification with a targeted gene-expression biomarker	223
Using unlabeled data to enhance fairness of medical AI	222
Mpox continues to spread in Africa and threatens global health security	222
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	222
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	221
Overcoming zero-sum thinking to advance US population health	221
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	220
Geographical shifting of cholera burden in Africa and its implications for disease control	219
A brief digital cognitive test improves Alzheimer’s disease detection	217
Peace in Colombia requires healing the scars of conflict on the mind and brain	216
The economics of investing in women and health	214
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	214
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	211
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	209
Advancing global antibiotic research, development and access	208
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	208
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	207
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	207
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	207
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	206
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	205
Clinical AI tools must convey predictive uncertainty for each individual patient	204
Use of mobile diagnostics and digital clinical trials in cardiology	204
Plasma proteome adaptations during feminizing gender-affirming hormone therapy	203
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	202
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	199
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	198
Strategies for shortening tuberculosis therapy	198
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	196
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	196
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	195
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	195
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	194
Familial confounding in the associations between maternal health and autism	194
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial	193
A benchmarking crisis in biomedical machine learning	193
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	192
Emerging diagnostics and therapeutics for Alzheimer disease	192
The limits of fair medical imaging AI in real-world generalization	192
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	192

A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	192
AI-generated text may have a role in evidence-based medicine	191
Self-improving generative foundation model for synthetic medical image generation and clinical applications	191
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	191
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	187
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	185
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	184
Genome-wide polygenic score to predict chronic kidney disease across ancestries	183
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	182
An integrated cell atlas of the lung in health and disease	182
Gene therapy for alcohol-use disorder	180
Could video games be good for your health?	179
A human brain circuit for addiction remission	177
A smart solution for detecting ear problems	176
ALS therapy hits molecular mark but misses clinical one	175
Pig-to-human transplants inch closer to reality	174
A framework to assess the effects of genetic risk factors on disability-adjusted life years	173
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer: circulating tumor DNA analysis of a randomized phase 3 trial	173
Human embryo models offer glimpse into early development	173