Nature Medicine

Article	Citations
Questionable role of new techniques in IVF embryo culture	3477
A genetic test to predict adverse drug reactions	1327
LLMs get a medical education	1157
In vivo gene editing for inherited vision loss	1009
Recapitulating sensory feedback in artificial skin	983
Telemonitoring for complicated pregnancies	980
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	887
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	855
Estimating the total effect of anthropogenic climate change on human health and wellbeing	821
HIV prevention through PrEP in cisgender women	782
Gene-edited pig liver successfully transplanted into human	773
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	770
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	719
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	684
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	624
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	621
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial	587
Author Correction: Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets	578
Mapping the effects of gender-affirming sex hormone therapy	576
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	566
An explainable foundation model for drug repurposing	522
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	497
Combating vaccine revisionism	490
The effect of geopolitical flux on antimicrobial resistance	481
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	473

Liquid biopsies and tumor mutational burden: the cutoff conundrum	472
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	468
HIPAA is a misunderstood and inadequate tool for protecting medical data	467
A global metric of immune health	463
FDA approves first drug to delay type 1 diabetes	451
Supported decision-making can advance clinical research participation for people with disabilities	447
First tumor-agnostic approval for an ADC	442
Concerns about the Burden of Proof studies	434
Targeted therapy for osteoarthritis: progress and pitfalls	430
The inconvenient reality of AI-assisted embryo selection in IVF	427
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	411
US vaccine policy must put America first	400
Biological aging might help to explain the rising risk of early-onset cancer	400
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	392
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study	392
An AI chatbot for talking therapy referrals	389
The WHO genomics program of work for equitable implementation of human genomics for global health	387
Who owns my health data?	385
The capacity of brain circuits to enhance psychiatry	379
Will ChatGPT transform healthcare?	378
How virtual reality therapy is shaping mental health	377
Soluble MAdCAM-1 as a biomarker in metastatic renal cell carcinoma	368
Ending the taboo on periods and period problems	368
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	363
Continuous glucose monitoring and intrapersonal variability in fasting glucose	361
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	359
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	357
Reducing the diagnostic odyssey in rare disease: why screening is not the only answer	357
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	349
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	343
The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome	342
Repotrectinib in NTRK fusion–positive advanced solid tumors: a phase 1/2 trial	342
PD-L1 and the dawn of modern cancer immunotherapy	334
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	323
Hippocampal network activity forecasts epileptic seizures	323
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	315
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	314
What Galen’s dissections reveal about tacit learning in modern medical education	313
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	312
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	311
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	307
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	306
Integrating the environmental and genetic architectures of aging and mortality	303
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	302
Integrated image-based deep learning and language models for primary diabetes care	301
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	300
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	298
A large language model for complex cardiology care	297
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	294
Author Correction: Digital consults in heart failure care: a randomized controlled trial	293

Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	293
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	292
The landscape of mRNA nanomedicine	285
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	283
WHO sets research agenda for refugee and migrant health	278
Mapping the cellular landscape of the brain	277
The effect of embryonic genome imbalances on pregnancy	276
How patient advocates influence health policy	276
Microbes convert plastic waste into paracetamol	273
An international treaty to regulate misuse of alcohol and cannabis	271
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	270
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	269
A gene-by-sex interaction contributes to liver disease susceptibility in women	262
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	259
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	259
Using unlabeled data to enhance fairness of medical AI	257
siRNA therapy lowers triglycerides in patients with rare condition	257
Use of mobile diagnostics and digital clinical trials in cardiology	254
Prenatal exposure to famine affects lifelong health	250
Machine learning improves prediction of clinical outcomes for invasive breast cancers	249
Silenced genomes	245
The path to safe, equitable and sustainable dialysis provision for people with chronic kidney disease	244
Using genetics to predict toxicity of cancer immunotherapy	243
Steps to prevent and respond to an H5N1 epidemic in the USA	242
Is AI actually improving healthcare?	241
Nature Medicine Commission on dialysis policy in low- and middle-income countries	238
The mind-bending power of placebo	236
A brief digital cognitive test improves Alzheimer’s disease detection	233
The patient is now in the room	231
Exposure to negative physical and social factors accelerates brain aging	230
A pocket-sized drug for p53-mutant cancers	229
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	228
Peace in Colombia requires healing the scars of conflict on the mind and brain	226
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	222
The Italian parliament first to recognize obesity as a chronic and relapsing disease	222
The visible and hidden mortality caused by flooding	221
Meningioma risk stratification with a targeted gene-expression biomarker	221
Oral small molecule GLP-1 receptor agonist aleniglipron in people with overweight or obesity: a randomized, double-blind, placebo-controlled phase 2b trial	220
Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes	220
Menstrual health without stigma	219
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	218
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	217
Overcoming zero-sum thinking to advance US population health	217
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	217
A new additive in the opioid supply is causing disastrous complications	215
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	211
Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study	210
Geographical shifting of cholera burden in Africa and its implications for disease control	210
AI-generated text may have a role in evidence-based medicine	209
Mpox continues to spread in Africa and threatens global health security	208
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	207
A benchmarking crisis in biomedical machine learning	207
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	207
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	207
Multi-omic definition of metabolic obesity through adipose tissue–microbiome interactions	206
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	204
Coproducing health research with Indigenous peoples	204
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	201
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	199
Familial confounding in the associations between maternal health and autism	199
Harnessing the power of biomarkers for diffuse intrinsic pontine gliomas	199
CRISPR−Cas9 CD33-deleted allogeneic hematopoietic cell transplantation with gemtuzumab ozogamicin maintenance in AML: a phase 1/2 trial	198
Plasma proteome adaptations during feminizing gender-affirming hormone therapy	198
The economics of investing in women and health	197
Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial	197
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	197
Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial	196
Clinical AI tools must convey predictive uncertainty for each individual patient	196
An African One Health network for antimicrobial resistance and neglected tropical diseases	196
Clinical profile and genomic characterization of the 2026 Bundibugyo virus index case in Uganda	193
Lassa fever countermeasures gather pace	192
Air pollution interventions for health	192
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	190
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	190
Adjuvanted inactivated rabies virus-vectored Lassa virus vaccine in healthy adults: a phase 1 trial	190
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	189
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	188
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	187
An international mega-analysis of psychedelic drug effects on brain circuit function	187
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	187

Strategies for shortening tuberculosis therapy	186
Physical activity for public health in the 21st century	185
Advancing global antibiotic research, development and access	185
Self-improving generative foundation model for synthetic medical image generation and clinical applications	184
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	183
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	183
A multimodal biomarker strategy to enhance diagnostic precision in neurodegenerative parkinsonism	182
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	182
The expanding landscape of GLP-1 medicines	182
‘Heading’ the ball linked to spikes in neural damage biomarkers	180
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	180
Fecal microbiota transplantation plus pembrolizumab and axitinib in metastatic renal cell carcinoma: the randomized phase 2 TACITO trial	179
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	179
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	178
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	177
Linavonkibart and pembrolizumab in immune checkpoint blockade-resistant advanced solid tumors: a phase 1 trial	175
An integrated cell atlas of the lung in health and disease	175
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	175
The limits of fair medical imaging AI in real-world generalization	174
Emerging diagnostics and therapeutics for Alzheimer disease	174