Nature Medicine

Article	Citations
SCOTUS v. reproductive health in United States	1808
Rise in ambient temperature is associated with increased mortality in Latin America	1579
Telemonitoring for complicated pregnancies	1502
LLMs get a medical education	970
Questionable role of new techniques in IVF embryo culture	798
A genetic test to predict adverse drug reactions	715
Easing the pain of endometriosis	680
Liquid biopsies and tumor mutational burden: the cutoff conundrum	657
A global metric of immune health	642
Recapitulating sensory feedback in artificial skin	634
In vivo gene editing for inherited vision loss	606
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	597
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	587
The capacity of brain circuits to enhance psychiatry	529
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	495
The effect of geopolitical flux on antimicrobial resistance	493
The inconvenient reality of AI-assisted embryo selection in IVF	493
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	486
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	449
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	447
Can an implanted minipump deliver for diabetes patients?	446
Combating vaccine revisionism	445
HIV prevention through PrEP in cisgender women	445
Hippocampal network activity forecasts epileptic seizures	440
Solving medicine’s data bottleneck: Nightingale Open Science	431

An explainable foundation model for drug repurposing	429
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	425
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	424
PD-L1 and the dawn of modern cancer immunotherapy	418
How virtual reality therapy is shaping mental health	415
The WHO genomics program of work for equitable implementation of human genomics for global health	403
HIPAA is a misunderstood and inadequate tool for protecting medical data	393
Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial	390
Estimating the total effect of anthropogenic climate change on human health and wellbeing	388
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	387
Gene-edited pig liver successfully transplanted into human	385
FDA approves first drug to delay type 1 diabetes	381
Supported decision-making can advance clinical research participation for people with disabilities	369
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	361
An AI chatbot for talking therapy referrals	358
The uncertain science of preimplantation and prenatal genetic testing	358
Author Correction: Digital consults in heart failure care: a randomized controlled trial	351
The role of research in China’s successful elimination of malaria	350
Author Correction: Unexplained post-acute infection syndromes	346
AI as a new paradigm for risk-based screening for breast cancer	345
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	343
Ending the taboo on periods and period problems	339
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	335
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	334
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	333
Continuous glucose monitoring and intrapersonal variability in fasting glucose	331
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	330
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	329
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	329
In utero origin of myelofibrosis presenting in adult monozygotic twins	326
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	323
First tumor-agnostic approval for an ADC	322
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	320
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	317
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	313
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	313
Anemia in women — an intractable problem that requires innovative solutions	313
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	311
Integrated image-based deep learning and language models for primary diabetes care	306
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	304
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	303
Will ChatGPT transform healthcare?	299
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	297
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	296
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	291
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	283
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	281
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	280
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	277
Concerns about the Burden of Proof studies	275

Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	270
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	269
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	268
The landscape of mRNA nanomedicine	266
Integrating the environmental and genetic architectures of aging and mortality	264
Targeted therapy for osteoarthritis: progress and pitfalls	264
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	262
Machine learning improves prediction of clinical outcomes for invasive breast cancers	261
WHO sets research agenda for refugee and migrant health	261
The Yearbook	260
An anti-obesity drug from the diabetes toolbox	259
An outdated loophole is letting faulty lab tests hit the market	258
Rethinking aspirin for heart health	258
Health in the Amazon	257
The visible and hidden mortality caused by flooding	257
Mapping the cellular landscape of the brain	256
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	255
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	252
Steps to prevent and respond to an H5N1 epidemic in the USA	251
The expanding universe of checkpoint inhibitors for nasopharyngeal cancer	249
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	244
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	243
An African One Health network for antimicrobial resistance and neglected tropical diseases	241
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	241
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	241
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	237
Health benefits of calorie restriction	232
A gene-by-sex interaction contributes to liver disease susceptibility in women	232
Prenatal exposure to famine affects lifelong health	229
How patient advocates influence health policy	228
siRNA therapy lowers triglycerides in patients with rare condition	225
Meningioma risk stratification with a targeted gene-expression biomarker	225
The effect of embryonic genome imbalances on pregnancy	224
Brain pathology of COVID-19	224
Using genetics to predict toxicity of cancer immunotherapy	223
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	219
Menstrual health without stigma	219
Coproducing health research with Indigenous peoples	218
Familial confounding in the associations between maternal health and autism	217
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	216
Microbes convert plastic waste into paracetamol	214
Using unlabeled data to enhance fairness of medical AI	214
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	213
An international treaty to regulate misuse of alcohol and cannabis	213
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	211
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy	210
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	207
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	207
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	206
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	204
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	204
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	201
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	201
Use of mobile diagnostics and digital clinical trials in cardiology	199
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	199
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	198
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	198
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	197
Clinical AI tools must convey predictive uncertainty for each individual patient	196
Strategies for shortening tuberculosis therapy	196
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	195
Peace in Colombia requires healing the scars of conflict on the mind and brain	194
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	193
AI-generated text may have a role in evidence-based medicine	193
Advancing global antibiotic research, development and access	193
Self-improving generative foundation model for synthetic medical image generation and clinical applications	192
Mpox continues to spread in Africa and threatens global health security	192
An integrated cell atlas of the lung in health and disease	191
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	190
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	190
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	189
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial	188
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	185
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	185
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	184
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	183
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	182
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	181
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	181
Emerging diagnostics and therapeutics for Alzheimer disease	181

Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	181
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	180
A benchmarking crisis in biomedical machine learning	179
The limits of fair medical imaging AI in real-world generalization	179
Genome-wide polygenic score to predict chronic kidney disease across ancestries	179
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	178
Gene therapy for alcohol-use disorder	177
Could video games be good for your health?	177
ALS therapy hits molecular mark but misses clinical one	176
Pig-to-human transplants inch closer to reality	174
A smart solution for detecting ear problems	173
A human brain circuit for addiction remission	173
A pinch of salt for heart disease	169
The unseen climate health risks of antimicrobial resistance in urban informal settlements	168
Deciphering the heritability of human height	167
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	166
Targeted radiation adds precision to cancer therapy	166
A framework to assess the effects of genetic risk factors on disability-adjusted life years	163
Human embryo models offer glimpse into early development	163
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	162
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	161
Countering the impact of the climate crisis on health will require data	161
Imatinib and the dawn of precision cancer therapy	161
Gene-editing breakthrough for a rare hereditary disorder	161
Author Correction: The impact of school opening model on SARS-CoV-2 community incidence and mortality	160
COVID-19 vaccination gives hope to eradicate polio	160
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	159
Hibernation science harnessed to treat obesity and modify metabolism	157
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	157
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	157
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	156
New neurons are born in the adult human brain	155
Adequate information about clinical trial results must be given to participants	154
Why paying individual people for their health data is a bad idea	153
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	153
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	153
Determinants and inequities in healthy working life expectancy in China	151
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	150
A federated learning system for precision oncology in Europe: DigiONE	148
Author Correction: Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis	147
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	145
Challenges with benchmarking of MDMA-assisted psychotherapy	145
The impact of school opening model on SARS-CoV-2 community incidence and mortality	144
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	144
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	143
The economic value of reducing avoidable mortality	143
Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year	142
Cities, communities and clinics can be testbeds for human exposome and aging research	142
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination	142
Caution at psychiatry’s psychedelic frontier	142
A H3K27M-targeted vaccine in adults with diffuse midline glioma	141
AI-guided precision parenteral nutrition for neonatal intensive care units	141
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	141
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics	140
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	140
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine	139
A neural stem-cell treatment for progressive multiple sclerosis	139
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	139
Multi-ancestry polygenic mechanisms of type 2 diabetes	138
Bacterial SNPs in the human gut microbiome associate with host BMI	137
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	137
The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology	136
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial	135
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma	135
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases	135
Permissive gun laws in the USA linked to thousands of child deaths	134
Targeting KRAS in cancer	132
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial	132
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial	131
Using implementation science to navigate the complexity of integrating genomics into healthcare	131
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	130
City-level impact of extreme temperatures and mortality in Latin America	129
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial	129
Mapping the mediators of Alzheimer’s disease	129
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial	129
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries	128
Balancing the risks of HIV transmission at low viral load	127
Boosting the efficacy of emergency contraception	126
Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases	123
Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk	123
Building resilience in heatwaves	123
The role of placebo control in clinical trials for neurodegenerative diseases	123
Evolution, genetic diversity, and health	122
11 clinical trials that will shape medicine in 2022	122
Information is a determinant of health	121
Large floods drive changes in cause-specific mortality in the United States	121
Defining a research agenda for environmental wastewater surveillance of pathogens	120
Allogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial	120
Author Correction: Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial	120
Author Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers	120
Tumor infiltrating lymphocyte approval heralds new era for precision cancer immunotherapy	120
Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease	120
Exercise therapy and self-management support for individuals with multimorbidity: a randomized and controlled trial	119
Gene therapies should be for all	118
It’s time to send children back to school	118