Nature Medicine

Article	Citations
SCOTUS v. reproductive health in United States	1559
Rise in ambient temperature is associated with increased mortality in Latin America	1463
Telemonitoring for complicated pregnancies	1458
How virtual reality therapy is shaping mental health	957
LLMs get a medical education	789
Questionable role of new techniques in IVF embryo culture	761
A genetic test to predict adverse drug reactions	719
Easing the pain of endometriosis	671
Liquid biopsies and tumor mutational burden: the cutoff conundrum	640
A global metric of immune health	622
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	602
Solving medicine’s data bottleneck: Nightingale Open Science	573
Recapitulating sensory feedback in artificial skin	570
In vivo gene editing for inherited vision loss	569
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	566
First tumor-agnostic approval for an ADC	519
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	516
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	491
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	476
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	467
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	449
An AI chatbot for talking therapy referrals	438
Can an implanted minipump deliver for diabetes patients?	424
The capacity of brain circuits to enhance psychiatry	423
HIV prevention through PrEP in cisgender women	421

Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	417
Estimating the total effect of anthropogenic climate change on human health and wellbeing	416
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	412
Combating vaccine revisionism	411
HIPAA is a misunderstood and inadequate tool for protecting medical data	409
Gene-edited pig liver successfully transplanted into human	409
FDA approves first drug to delay type 1 diabetes	405
The WHO genomics program of work for equitable implementation of human genomics for global health	396
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	393
Supported decision-making can advance clinical research participation for people with disabilities	382
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	377
Anemia in women — an intractable problem that requires innovative solutions	376
Publisher Correction: Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes	375
In utero origin of myelofibrosis presenting in adult monozygotic twins	372
Author Correction: Digital consults in heart failure care: a randomized controlled trial	365
The role of research in China’s successful elimination of malaria	362
Concerns about the Burden of Proof studies	360
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	358
PD-L1 and the dawn of modern cancer immunotherapy	357
The inconvenient reality of AI-assisted embryo selection in IVF	354
The uncertain science of preimplantation and prenatal genetic testing	348
Targeted therapy for osteoarthritis: progress and pitfalls	342
Integrating the environmental and genetic architectures of aging and mortality	338
Author Correction: Unexplained post-acute infection syndromes	334
An explainable foundation model for drug repurposing	333
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	330
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	327
Will ChatGPT transform healthcare?	320
Continuous glucose monitoring and intrapersonal variability in fasting glucose	320
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	320
The landscape of mRNA nanomedicine	319
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	319
Hippocampal network activity forecasts epileptic seizures	314
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	311
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	308
Phenotypic signatures in clinical data enable systematic identification of patients for genetic testing	303
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	299
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	297
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	297
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	295
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	293
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	291
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	291
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	289
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	287
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	287
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	285
Dexamethasone modulates immature neutrophils and interferon programming in severe COVID-19	283
AI as a new paradigm for risk-based screening for breast cancer	281
Integrated image-based deep learning and language models for primary diabetes care	280

Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	280
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	277
Valsartan in early-stage hypertrophic cardiomyopathy: a randomized phase 2 trial	272
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	269
WHO sets research agenda for refugee and migrant health	267
Machine learning improves prediction of clinical outcomes for invasive breast cancers	266
The Yearbook	265
An anti-obesity drug from the diabetes toolbox	263
An outdated loophole is letting faulty lab tests hit the market	262
Rethinking aspirin for heart health	260
High COVID-19 death toll in Africa	260
Health in the Amazon	259
The visible and hidden mortality caused by flooding	257
Mapping the cellular landscape of the brain	255
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	252
Familial confounding in the associations between maternal health and autism	251
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	251
Steps to prevent and respond to an H5N1 epidemic in the USA	250
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	248
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	246
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	246
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	245
A benchmarking crisis in biomedical machine learning	245
The expanding universe of checkpoint inhibitors for nasopharyngeal cancer	244
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	242
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	240
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	240
Coproducing health research with Indigenous peoples	239
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	236
An African One Health network for antimicrobial resistance and neglected tropical diseases	236
A gene-by-sex interaction contributes to liver disease susceptibility in women	235
Health benefits of calorie restriction	232
How patient advocates influence health policy	231
Prenatal exposure to famine affects lifelong health	231
siRNA therapy lowers triglycerides in patients with rare condition	226
Meningioma risk stratification with a targeted gene-expression biomarker	225
The effect of embryonic genome imbalances on pregnancy	223
Menstrual health without stigma	220
Using genetics to predict toxicity of cancer immunotherapy	220
Brain pathology of COVID-19	220
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	219
Use of mobile diagnostics and digital clinical trials in cardiology	219
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	216
AI-generated text may have a role in evidence-based medicine	213
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	212
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	210
Self-improving generative foundation model for synthetic medical image generation and clinical applications	209
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	208
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	207
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	207
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	205
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	205
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	202
Distinct mechanisms of long-term virologic control in two HIV-infected individuals after treatment interruption of anti-retroviral therapy	202
Clinical AI tools must convey predictive uncertainty for each individual patient	200
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	200
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	196
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	196
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	195
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	194
Using unlabeled data to enhance fairness of medical AI	193
Immunogenicity and reactogenicity of heterologous ChAdOx1 nCoV-19/mRNA vaccination	193
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	193
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	192
Mpox continues to spread in Africa and threatens global health security	192
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	192
Evaluation of the extended efficacy of the Dengvaxia vaccine against symptomatic and subclinical dengue infection	191
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	190
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	190
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	189
The limits of fair medical imaging AI in real-world generalization	188
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	188
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	187
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	186
Durvalumab with platinum-pemetrexed for unresectable pleural mesothelioma: survival, genomic and immunologic analyses from the phase 2 PrE0505 trial	186
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	186
Genome-wide polygenic score to predict chronic kidney disease across ancestries	186
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	185
Emerging diagnostics and therapeutics for Alzheimer disease	185
Advancing global antibiotic research, development and access	184

An integrated cell atlas of the lung in health and disease	183
Gene therapy for alcohol-use disorder	182
Could video games be good for your health?	181
Pig-to-human transplants inch closer to reality	179
ALS therapy hits molecular mark but misses clinical one	179
A human brain circuit for addiction remission	177
A smart solution for detecting ear problems	175
A pinch of salt for heart disease	175
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	175
Challenges with benchmarking of MDMA-assisted psychotherapy	174
The impact of school opening model on SARS-CoV-2 community incidence and mortality	172
Immunogenicity and safety of the CoronaVac inactivated vaccine in patients with autoimmune rheumatic diseases: a phase 4 trial	170
Deciphering the heritability of human height	170
The unseen climate health risks of antimicrobial resistance in urban informal settlements	170
Targeted radiation adds precision to cancer therapy	169
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	169
A framework to assess the effects of genetic risk factors on disability-adjusted life years	167
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	167
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	166
Human embryo models offer glimpse into early development	166
Gene-editing breakthrough for a rare hereditary disorder	165
Using implementation science to navigate the complexity of integrating genomics into healthcare	164
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	164
New neurons are born in the adult human brain	163
Imatinib and the dawn of precision cancer therapy	163
COVID-19 vaccination gives hope to eradicate polio	162
Countering the impact of the climate crisis on health will require data	162
Adequate information about clinical trial results must be given to participants	162
Author Correction: Inhibition of hypoxia-inducible factor-2α in renal cell carcinoma with belzutifan: a phase 1 trial and biomarker analysis	161
Author Correction: The impact of school opening model on SARS-CoV-2 community incidence and mortality	161
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	159
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	159
Why paying individual people for their health data is a bad idea	158
Hibernation science harnessed to treat obesity and modify metabolism	158
Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year	158
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	156
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	155
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	154
A federated learning system for precision oncology in Europe: DigiONE	153
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	152
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	151
Multi-ancestry polygenic mechanisms of type 2 diabetes	147
A neural stem-cell treatment for progressive multiple sclerosis	145
Determinants and inequities in healthy working life expectancy in China	145
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial	145
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma	145
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	144
Reduction in life expectancy in Brazil after COVID-19	143
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination	142
City-level impact of extreme temperatures and mortality in Latin America	142
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	141
A H3K27M-targeted vaccine in adults with diffuse midline glioma	141
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	140
Cities, communities and clinics can be testbeds for human exposome and aging research	139
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics	138
Caution at psychiatry’s psychedelic frontier	138
AI-guided precision parenteral nutrition for neonatal intensive care units	138
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	138
Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination	137
Bacterial SNPs in the human gut microbiome associate with host BMI	134
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases	133
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	133
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial	132
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial	132
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial	132
The economic value of reducing avoidable mortality	130
The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology	130
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial	130
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	130
Mapping the mediators of Alzheimer’s disease	129
Targeting KRAS in cancer	129
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine	129
Boosting the efficacy of emergency contraception	128
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries	128
‘Inverse vaccines’ could treat autoimmune disease — from multiple sclerosis to celiac disease	128
Balancing the risks of HIV transmission at low viral load	128
Tumor infiltrating lymphocyte approval heralds new era for precision cancer immunotherapy	128
11 clinical trials that will shape medicine in 2022	127
The role of placebo control in clinical trials for neurodegenerative diseases	127
Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk	126
Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality	126
Large floods drive changes in cause-specific mortality in the United States	126
Publisher Correction: Prisons as ecological drivers of fitness-compensated multidrug-resistant Mycobacterium tuberculosis	126
Pakistan is failing in maternal and neonatal tetanus elimination	125
Facilitating limb movement after stroke	124
Author Correction: Subclassification of obesity for precision prediction of cardiometabolic diseases	124
Building resilience in heatwaves	124
Improving scientific integrity in Chinese medical institutions with the Hospital Research Integrity Alliance	123
Evolution, genetic diversity, and health	123
Author Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers	122
Author Correction: Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression	121
Personalized lab test models to quantify disease potentials in healthy individuals	119
Emergence of measles during the COVID-19 pandemic threatens Pakistan’s children and the wider region	119
Clinical trial design during and beyond the pandemic: the I-SPY COVID trial	118
Fixed-dose combination therapy for the prevention of atherosclerotic cardiovascular disease	118