Nature Medicine

Article	Citations
Questionable role of new techniques in IVF embryo culture	2955
A genetic test to predict adverse drug reactions	1015
LLMs get a medical education	996
In vivo gene editing for inherited vision loss	933
Recapitulating sensory feedback in artificial skin	907
Telemonitoring for complicated pregnancies	899
Rise in ambient temperature is associated with increased mortality in Latin America	796
Easing the pain of endometriosis	763
SCOTUS v. reproductive health in United States	712
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	690
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	686
A global metric of immune health	684
HIV prevention through PrEP in cisgender women	679
Supported decision-making can advance clinical research participation for people with disabilities	647
Will ChatGPT transform healthcare?	638
Targeted therapy for osteoarthritis: progress and pitfalls	586
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	568
The impact of an oral purified microbiome therapeutic on the gastrointestinal microbiome	551
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	551
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	542
First tumor-agnostic approval for an ADC	535
Estimating the total effect of anthropogenic climate change on human health and wellbeing	534
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	519
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	513
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	508

Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	499
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial	491
Author Correction: Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets	481
The inconvenient reality of AI-assisted embryo selection in IVF	475
Author Correction: Digital consults in heart failure care: a randomized controlled trial	457
Mapping the effects of gender-affirming sex hormone therapy	456
How virtual reality therapy is shaping mental health	447
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	430
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	423
The landscape of mRNA nanomedicine	421
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	417
The WHO genomics program of work for equitable implementation of human genomics for global health	412
The role of research in China’s successful elimination of malaria	405
Soluble MAdCAM-1 as a biomarker in metastatic renal cell carcinoma	397
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	394
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	387
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	382
Who owns my health data?	366
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	363
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	359
Ending the taboo on periods and period problems	357
FDA approves first drug to delay type 1 diabetes	350
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	350
Solving medicine’s data bottleneck: Nightingale Open Science	349
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	349
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	343
Integrating the environmental and genetic architectures of aging and mortality	340
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	339
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	337
Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	336
Integrated image-based deep learning and language models for primary diabetes care	334
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	331
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	325
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	325
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	324
The effect of geopolitical flux on antimicrobial resistance	323
Repotrectinib in NTRK fusion–positive advanced solid tumors: a phase 1/2 trial	322
A large language model for complex cardiology care	318
Continuous glucose monitoring and intrapersonal variability in fasting glucose	316
Gene-edited pig liver successfully transplanted into human	312
The capacity of brain circuits to enhance psychiatry	311
US vaccine policy must put America first	309
Author Correction: Unexplained post-acute infection syndromes	308
An explainable foundation model for drug repurposing	307
Liquid biopsies and tumor mutational burden: the cutoff conundrum	304
Hippocampal network activity forecasts epileptic seizures	301
Author Correction: Global, regional, and national burden of chronic respiratory diseases and impact of the COVID-19 pandemic, 1990–2023: a Global Burden of Disease study	298
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	281
PD-L1 and the dawn of modern cancer immunotherapy	280
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	280

Concerns about the Burden of Proof studies	279
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	279
HIPAA is a misunderstood and inadequate tool for protecting medical data	278
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	276
In utero origin of myelofibrosis presenting in adult monozygotic twins	275
Combating vaccine revisionism	273
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	273
An AI chatbot for talking therapy referrals	270
WHO sets research agenda for refugee and migrant health	269
An anti-obesity drug from the diabetes toolbox	269
Mapping the cellular landscape of the brain	266
How patient advocates influence health policy	263
The effect of embryonic genome imbalances on pregnancy	262
Microbes convert plastic waste into paracetamol	261
An international treaty to regulate misuse of alcohol and cannabis	260
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	259
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	259
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	258
A gene-by-sex interaction contributes to liver disease susceptibility in women	256
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	253
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	253
siRNA therapy lowers triglycerides in patients with rare condition	252
Clinical AI tools must convey predictive uncertainty for each individual patient	250
Coproducing health research with Indigenous peoples	249
Using genetics to predict toxicity of cancer immunotherapy	249
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	248
AI-generated text may have a role in evidence-based medicine	242
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	241
The Italian parliament first to recognize obesity as a chronic and relapsing disease	241
A pocket-sized drug for p53-mutant cancers	240
Mpox continues to spread in Africa and threatens global health security	240
An African One Health network for antimicrobial resistance and neglected tropical diseases	239
Prenatal exposure to famine affects lifelong health	237
Machine learning improves prediction of clinical outcomes for invasive breast cancers	233
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	232
Peace in Colombia requires healing the scars of conflict on the mind and brain	231
The path to safe, equitable and sustainable dialysis provision for people with chronic kidney disease	230
Silenced genomes	230
Overcoming zero-sum thinking to advance US population health	228
The mind-bending power of placebo	225
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	221
A brief digital cognitive test improves Alzheimer’s disease detection	221
Meningioma risk stratification with a targeted gene-expression biomarker	220
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	219
Steps to prevent and respond to an H5N1 epidemic in the USA	217
Is AI actually improving healthcare?	215
Global, regional and national burden of ischemic heart disease attributable to suboptimal diet, 1990–2023: a Global Burden of Disease study	213
An international mega-analysis of psychedelic drug effects on brain circuit function	212
The patient is now in the room	211
Physical activity for public health in the 21st century	210
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	209
Exposure to negative physical and social factors accelerates brain aging	208
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	208
Familial confounding in the associations between maternal health and autism	203
Genome-wide polygenic score to predict chronic kidney disease across ancestries	202
Use of mobile diagnostics and digital clinical trials in cardiology	202
Geographical shifting of cholera burden in Africa and its implications for disease control	201
Linavonkibart and pembrolizumab in immune checkpoint blockade-resistant advanced solid tumors: a phase 1 trial	201
The expanding landscape of GLP-1 medicines	200
Using unlabeled data to enhance fairness of medical AI	199
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	198
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	195
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	193
Detection of undiagnosed liver cirrhosis via AI-enabled electrocardiogram: a pragmatic, cluster-randomized clinical trial	191
A benchmarking crisis in biomedical machine learning	190
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	188
Fecal microbiota transplantation plus pembrolizumab and axitinib in metastatic renal cell carcinoma: the randomized phase 2 TACITO trial	187
Plasma proteome adaptations during feminizing gender-affirming hormone therapy	186
Anticoagulation to prevent ischemic stroke and neurocognitive impairment in atrial fibrillation: the BRAIN-AF randomized clinical trial	186
Menstrual health without stigma	185
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	184
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	184
The visible and hidden mortality caused by flooding	183
Multi-omic definition of metabolic obesity through adipose tissue–microbiome interactions	183
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	181
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	180
Air pollution interventions for health	179
Nature Medicine Commission on dialysis policy in low- and middle-income countries	179
Genetic regulation across germline and somatic variation on the Y chromosome contributes to type 2 diabetes	179
The economics of investing in women and health	179

Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	179
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	179
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	177
Emerging diagnostics and therapeutics for Alzheimer disease	177
Self-improving generative foundation model for synthetic medical image generation and clinical applications	176
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	176
Advancing global antibiotic research, development and access	176
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	176
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	176
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	175
The limits of fair medical imaging AI in real-world generalization	174
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	174
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	173
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	173
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	171
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	170
Strategies for shortening tuberculosis therapy	169
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	169
An integrated cell atlas of the lung in health and disease	168
Could video games be good for your health?	166
Gene therapy for alcohol-use disorder	166
A human brain circuit for addiction remission	165
ALS therapy hits molecular mark but misses clinical one	164
A smart solution for detecting ear problems	164
Pig-to-human transplants inch closer to reality	163
Human embryo models offer glimpse into early development	163
A framework to assess the effects of genetic risk factors on disability-adjusted life years	163
Permissive gun laws in the USA linked to thousands of child deaths	162
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	160
Hope for patients facing deadly infections	160
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer: circulating tumor DNA analysis of a randomized phase 3 trial	160
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	160
A neural stem-cell treatment for progressive multiple sclerosis	160
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	159
Hope for control of a centuries-old epidemic	159
Enhancing prenatal spinal surgery with stem cells	159
Gene-editing breakthrough for a rare hereditary disorder	157
Hibernation science harnessed to treat obesity and modify metabolism	156
Using implementation science to navigate the complexity of integrating genomics into healthcare	156
Imatinib and the dawn of precision cancer therapy	156
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	155
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	154
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	154
Adequate information about clinical trial results must be given to participants	153
Countering the impact of the climate crisis on health will require data	153
Author Correction: Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020	153
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	152
The unseen climate health risks of antimicrobial resistance in urban informal settlements	152
Deciphering the heritability of human height	152
Student-led efforts promoting inclusivity and belonging in US medical schools	151
A biomarker of Alzheimer’s disease could be a useful diagnostic tool for other amyloidoses	150
New neurons are born in the adult human brain	147
AI stethoscope trial highlights the perils of implementation gaps	146
A federated learning system for precision oncology in Europe: DigiONE	146
Blood tests for Alzheimer’s disease could reshape research and care	146
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	146
Teaching machines to doubt	145
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	145
Editorial Expression of Concern: Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization	145
Concern for the validity of short-term dietary crossover trials	145
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	143
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	143
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	143
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	143
City-level impact of extreme temperatures and mortality in Latin America	142
The economic value of reducing avoidable mortality	141
Target product profiles for treatments to delay or prevent symptomatic Alzheimer’s disease	141
Why paying individual people for their health data is a bad idea	141
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial	141
Africa’s continental plan to end cholera	141
The gut microbiome as a fingerprint of antibiotic use history	141
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	140
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics	140
DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial	140
Determinants and inequities in healthy working life expectancy in China	139
Effects of a comprehensive antibiotic stewardship program on antibiotic prescribing for acute respiratory infections in rural facilities: a cluster randomized trial	139
Bacterial SNPs in the human gut microbiome associate with host BMI	138
Mapping the human chemical exposome for public health	137
New gene-editing approaches for β-hemoglobinopathies	137
Disentangling climate hazards from demographic change in climate–health projections	137
Cities, communities and clinics can be testbeds for human exposome and aging research	137
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases	136
AI-guided precision parenteral nutrition for neonatal intensive care units	136
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	136
Physicians as context engineers in the era of generative AI	136
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial	136
A H3K27M-targeted vaccine in adults with diffuse midline glioma	135
Targeting KRAS in cancer	135
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	135
Multi-ancestry polygenic mechanisms of type 2 diabetes	134
An atlas of exposome–phenome associations in health and disease risk	134
Targeted radiation adds precision to cancer therapy	134
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial	134
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	134
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	133