Nature Medicine

Article	Citations
Questionable role of new techniques in IVF embryo culture	2318
A genetic test to predict adverse drug reactions	1870
LLMs get a medical education	1611
Liquid biopsies and tumor mutational burden: the cutoff conundrum	863
In vivo gene editing for inherited vision loss	782
Recapitulating sensory feedback in artificial skin	775
Telemonitoring for complicated pregnancies	755
Rise in ambient temperature is associated with increased mortality in Latin America	706
Easing the pain of endometriosis	646
SCOTUS v. reproductive health in United States	639
Longitudinal analysis shows how microbiome changes might influence responses to immune checkpoint blockade	635
Author Correction: Financial incentives for COVID-19 vaccines in a rural low-resource setting: a cluster-randomized trial	633
Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial	612
Can an implanted minipump deliver for diabetes patients?	588
Author Correction: Single-cell guided prenatal derivation of primary fetal epithelial organoids from human amniotic and tracheal fluids	558
Not all KRAS-mutated pancreatic cancers are equal — mutant dosage matters	557
The inconvenient reality of AI-assisted embryo selection in IVF	547
Author Correction: Multiomic neuropathology improves diagnostic accuracy in pediatric neuro-oncology	520
A global metric of immune health	508
HIV prevention through PrEP in cisgender women	502
An AI chatbot for talking therapy referrals	499
Effects of vutrisiran on cardiac structure and function in patients with transthyretin amyloidosis with cardiomyopathy: secondary outcomes of the HELIOS-B trial	490
Author Correction: Pembrolizumab and cabozantinib in recurrent metastatic head and neck squamous cell carcinoma: a phase 2 trial	484
The WHO genomics program of work for equitable implementation of human genomics for global health	453
First tumor-agnostic approval for an ADC	448

The effect of geopolitical flux on antimicrobial resistance	435
Pregnant and lactating women should be included in clinical trials for cardiovascular disease	431
A fluid biomarker accurately detects tau aggregate pathology in Alzheimer’s disease	424
Estimating the total effect of anthropogenic climate change on human health and wellbeing	415
Promoting gender equity in the scientific and health workforce is essential to improve women’s health	410
Gene-edited pig liver successfully transplanted into human	406
Supported decision-making can advance clinical research participation for people with disabilities	406
Author Correction: Digital consults in heart failure care: a randomized controlled trial	404
FDA approves first drug to delay type 1 diabetes	403
The capacity of brain circuits to enhance psychiatry	401
Targeting the angiopoietin-like protein 3/8 complex with a monoclonal antibody in patients with mixed hyperlipidemia: a phase 1 trial	392
The role of research in China’s successful elimination of malaria	392
Author Correction: Unexplained post-acute infection syndromes	390
PD-L1 and the dawn of modern cancer immunotherapy	389
Solving medicine’s data bottleneck: Nightingale Open Science	388
Publisher Correction: GD2-targeting CAR T cells in high-risk neuroblastoma: a phase 1/2 trial	387
AI as a new paradigm for risk-based screening for breast cancer	387
Autologous macrophage therapy for liver cirrhosis: a phase 2 open-label randomized controlled trial	381
Concerns about the Burden of Proof studies	372
Continuous glucose monitoring and intrapersonal variability in fasting glucose	372
Targeted therapy for osteoarthritis: progress and pitfalls	362
Author Correction: Neuroprotective role of Sirt1 in mammalian models of Huntington’s disease through activation of multiple Sirt1 targets	360
Remotely delivered weight management for people with long COVID and overweight: the randomized wait-list-controlled ReDIRECT trial	358
CanScreen5, a global repository for breast, cervical and colorectal cancer screening programs	357
Combating vaccine revisionism	348
Patritumab deruxtecan in leptomeningeal metastatic disease of solid tumors: the phase 2 TUXEDO-3 trial	343
Pembrolizumab for advanced urothelial carcinoma: exploratory ctDNA biomarker analyses of the KEYNOTE-361 phase 3 trial	342
Ending the taboo on periods and period problems	342
Trastuzumab deruxtecan in HER2-positive breast cancer with brain metastases: a single-arm, phase 2 trial	340
Hippocampal network activity forecasts epileptic seizures	334
Changing climate and socioeconomic factors contribute to global antimicrobial resistance	334
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites	330
An explainable foundation model for drug repurposing	328
HIPAA is a misunderstood and inadequate tool for protecting medical data	326
Education of healthcare professionals to improve guideline adherence in atrial fibrillation: the STEEER-AF cluster-randomized clinical trial	324
Will ChatGPT transform healthcare?	321
Molecular classification to refine surgical and radiotherapeutic decision-making in meningioma	321
Low-voltage-area ablation for persistent atrial fibrillation: a randomized controlled trial	320
Neoadjuvant nivolumab or nivolumab plus ipilimumab in early-stage triple-negative breast cancer: a phase 2 adaptive trial	312
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses	311
In vivo topical gene therapy for recessive dystrophic epidermolysis bullosa: a phase 1 and 2 trial	311
Integrated image-based deep learning and language models for primary diabetes care	309
In utero origin of myelofibrosis presenting in adult monozygotic twins	307
Integrating the environmental and genetic architectures of aging and mortality	305
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	303
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer’s disease	300
How virtual reality therapy is shaping mental health	296
Licensed H5N1 vaccines generate cross-neutralizing antibodies against highly pathogenic H5N1 clade 2.3.4.4b influenza virus	296
Gut microbiome correlates of response and toxicity following anti-CD19 CAR T cell therapy	295
Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality	291

Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease	291
Estimating future heat-related and cold-related mortality under climate change, demographic and adaptation scenarios in 854 European cities	291
The uncertain science of preimplantation and prenatal genetic testing	289
The landscape of mRNA nanomedicine	285
IL-6 inhibition with clazakizumab in patients receiving maintenance dialysis: a randomized phase 2b trial	285
Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	280
Health in the Amazon	279
Rethinking aspirin for heart health	277
An outdated loophole is letting faulty lab tests hit the market	276
An anti-obesity drug from the diabetes toolbox	275
WHO sets research agenda for refugee and migrant health	275
The Yearbook	274
Mapping the cellular landscape of the brain	271
Using genetics to predict toxicity of cancer immunotherapy	270
How patient advocates influence health policy	270
The effect of embryonic genome imbalances on pregnancy	269
Brain pathology of COVID-19	265
Menstrual health without stigma	263
Air pollution interventions for health	263
An international treaty to regulate misuse of alcohol and cannabis	262
Microbes convert plastic waste into paracetamol	262
Publisher Correction: Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	260
From neoadjuvant to organ-sparing immunotherapy for colorectal cancer	260
Reply to Guyton, J. R. & Boden, W. E.; Schreiber, S. et al.	259
Immune reconstitution inflammatory syndrome drives emergence of HIV drug resistance from multiple anatomic compartments in a person living with HIV	257
Open Letter to G7 and G20 leaders: resolve global crises to secure our future	257
A gene-by-sex interaction contributes to liver disease susceptibility in women	252
Health benefits of calorie restriction	250
An African One Health network for antimicrobial resistance and neglected tropical diseases	245
Steps to prevent and respond to an H5N1 epidemic in the USA	242
Anti-amyloid could help prevent genetic form of Alzheimer’s disease	242
Acquired blood mutations cause acute kidney injury via dysregulated inflammation	240
The visible and hidden mortality caused by flooding	240
siRNA therapy lowers triglycerides in patients with rare condition	237
Mpox continues to spread in Africa and threatens global health security	237
Meningioma risk stratification with a targeted gene-expression biomarker	235
Machine learning improves prediction of clinical outcomes for invasive breast cancers	234
Prenatal exposure to famine affects lifelong health	234
Coproducing health research with Indigenous peoples	233
Author Correction: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury	231
Multiomic analyses implicate a neurodevelopmental program in the pathogenesis of cerebral arachnoid cysts	231
A brief digital cognitive test improves Alzheimer’s disease detection	230
Geographical shifting of cholera burden in Africa and its implications for disease control	230
Peace in Colombia requires healing the scars of conflict on the mind and brain	228
The economics of investing in women and health	226
Use of mobile diagnostics and digital clinical trials in cardiology	225
Author Correction: Autologous T cell therapy for PRAME+ advanced solid tumors in HLA-A*02+ patients: a phase 1 trial	225
Plasma proteome adaptations during feminizing gender-affirming hormone therapy	225
Overcoming zero-sum thinking to advance US population health	224
The mind-bending power of placebo	223
Advancing global antibiotic research, development and access	222
A benchmarking crisis in biomedical machine learning	221
Clinical AI tools must convey predictive uncertainty for each individual patient	217
Prospective implementation of AI-assisted screen reading to improve early detection of breast cancer	217
Multi-omic profiling a defined bacterial consortium for treatment of recurrent Clostridioides difficile infection	216
Using unlabeled data to enhance fairness of medical AI	212
D3S-001 in advanced solid tumors with KRASG12C mutations: a phase 1 trial	211
Oral obeldesivir provides postexposure protection against Marburg virus in nonhuman primates	211
Strategies for shortening tuberculosis therapy	209
Maternal diabetes and risk of attention-deficit/hyperactivity disorder in offspring in a multinational cohort of 3.6 million mother–child pairs	209
Familial confounding in the associations between maternal health and autism	207
Determinants of COVID-19 vaccination status and hesitancy among older adults in China	207
Microbiome–metabolome dynamics associated with impaired glucose control and responses to lifestyle changes	206
Technology-assisted cognitive-behavioral therapy for perinatal depression delivered by lived-experience peers: a cluster-randomized noninferiority trial	205
Simulation-based estimates and projections of global, regional and country-level maternal mortality by cause, 1990–2050	204
Detection of early seeding of Richter transformation in chronic lymphocytic leukemia	203
Safety and immunogenicity of a ferritin nanoparticle H2 influenza vaccine in healthy adults: a phase 1 trial	202
Salt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial	200
Ustekinumab for type 1 diabetes in adolescents: a multicenter, double-blind, randomized phase 2 trial	200
Mutations in the U4 snRNA gene RNU4-2 cause one of the most prevalent monogenic neurodevelopmental disorders	199
Tau-targeting antisense oligonucleotide MAPTRx in mild Alzheimer’s disease: a phase 1b, randomized, placebo-controlled trial	198
Intratumoral oncolytic herpes virus G47∆ for residual or recurrent glioblastoma: a phase 2 trial	198
The airway microbiome mediates the interaction between environmental exposure and respiratory health in humans	198
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer	197
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations	197
A meta-analysis of GFR slope as a surrogate endpoint for kidney failure	196
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis	196
AI-generated text may have a role in evidence-based medicine	195
Self-improving generative foundation model for synthetic medical image generation and clinical applications	194
Personalized brain circuit scores identify clinically distinct biotypes in depression and anxiety	194

Emerging diagnostics and therapeutics for Alzheimer disease	193
The limits of fair medical imaging AI in real-world generalization	193
Genome-wide polygenic score to predict chronic kidney disease across ancestries	192
Ulcerative colitis is characterized by a plasmablast-skewed humoral response associated with disease activity	192
A digital health algorithm to guide antibiotic prescription in pediatric outpatient care: a cluster randomized controlled trial	187
Smartwatch- and smartphone-based remote assessment of brain health and detection of mild cognitive impairment	186
Risk of hematological malignancies from CT radiation exposure in children, adolescents and young adults	186
Dupilumab in patients with prurigo nodularis: two randomized, double-blind, placebo-controlled phase 3 trials	185
Gene therapy for alcohol-use disorder	184
An integrated cell atlas of the lung in health and disease	184
A human brain circuit for addiction remission	183
Could video games be good for your health?	183
A smart solution for detecting ear problems	182
ALS therapy hits molecular mark but misses clinical one	181
Pig-to-human transplants inch closer to reality	180
A framework to assess the effects of genetic risk factors on disability-adjusted life years	176
Human embryo models offer glimpse into early development	174
A neural stem-cell treatment for progressive multiple sclerosis	174
Author Correction: The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial	174
Permissive gun laws in the USA linked to thousands of child deaths	173
Concern for the validity of short-term dietary crossover trials	173
Hope for patients facing deadly infections	173
Author Correction: The impact of school opening model on SARS-CoV-2 community incidence and mortality	170
Author Correction: Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants	170
New neurons are born in the adult human brain	169
Africa’s continental plan to end cholera	168
Retraction Note: EGFR and MET receptor tyrosine kinase–altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers	167
Gene-editing breakthrough for a rare hereditary disorder	167
Imatinib and the dawn of precision cancer therapy	165
Publisher Correction: Allogeneic CD5-specific CAR-T therapy for relapsed/refractory T-ALL: a phase 1 trial	163
Author Correction: Neoadjuvant clinical trials provide a window of opportunity for cancer drug discovery	163
Advancing clinical genomics with Middle Eastern and South Asian pangenomes	163
Adequate information about clinical trial results must be given to participants	162
Why paying individual people for their health data is a bad idea	162
Targeted radiation adds precision to cancer therapy	162
DASH4D diet for glycemic control and glucose variability in type 2 diabetes: a randomized crossover trial	161
Using implementation science to navigate the complexity of integrating genomics into healthcare	159
Neoadjuvant atezolizumab plus chemotherapy in gastric and gastroesophageal junction adenocarcinoma: the phase 2 PANDA trial	158
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster	156
AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial	156
AI-guided precision parenteral nutrition for neonatal intensive care units	156
Impact of tumor microenvironment on efficacy of anti-CD19 CAR T cell therapy or chemotherapy and transplant in large B cell lymphoma	156
First-line serplulimab or placebo plus chemotherapy in PD-L1-positive esophageal squamous cell carcinoma: a randomized, double-blind phase 3 trial	155
Variability of strain engraftment and predictability of microbiome composition after fecal microbiota transplantation across different diseases	155
Multi-ancestry polygenic mechanisms of type 2 diabetes	154
An updated framework for SARS-CoV-2 variants reflects the unpredictability of viral evolution	152
Integrating liver endpoints in clinical trials of cardiovascular and kidney disease	151
Early detection of multiple cancer types using multidimensional cell-free DNA fragmentomics	151
Neutralizing antibodies against the SARS-CoV-2 Omicron variant BA.1 following homologous and heterologous CoronaVac or BNT162b2 vaccination	151
City-level impact of extreme temperatures and mortality in Latin America	150
CD40 ligand antagonist dazodalibep in Sjögren’s disease: a randomized, double-blinded, placebo-controlled, phase 2 trial	150
Countering the impact of the climate crisis on health will require data	149
The unseen climate health risks of antimicrobial resistance in urban informal settlements	148
The VolREthics initiative to protect the well-being of healthy volunteers in biomedical research	148
Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial	147
A H3K27M-targeted vaccine in adults with diffuse midline glioma	147
Cities, communities and clinics can be testbeds for human exposome and aging research	146
Single-nucleus chromatin accessibility and transcriptomic map of breast tissues of women of diverse genetic ancestry	146
Pre-existing adaptive immunity to the RNA-editing enzyme Cas13d in humans	146
Hibernation science harnessed to treat obesity and modify metabolism	145
Differential peripheral immune signatures elicited by vegan versus ketogenic diets in humans	145
Risk factors for PICU admission and death among children and young people hospitalized with COVID-19 and PIMS-TS in England during the first pandemic year	145
A federated learning system for precision oncology in Europe: DigiONE	144
Early versus deferred use of CDK4/6 inhibitors in advanced breast cancer: circulating tumor DNA analysis of a randomized phase 3 trial	144
Author Correction: Impact of the indigenous rotavirus vaccine Rotavac in the Universal Immunization Program in India during 2016–2020	144
Deciphering the heritability of human height	141
Bacterial SNPs in the human gut microbiome associate with host BMI	140
Escitalopram for agitation in Alzheimer’s dementia: a randomized controlled phase 3 trial	139
The economic value of reducing avoidable mortality	139
Teaching machines to doubt	139
Determinants and inequities in healthy working life expectancy in China	138
Author Correction: T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection	137
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial	137
Targeting KRAS in cancer	137
Author Correction: Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma	136
T cell characteristics associated with toxicity to immune checkpoint blockade in patients with melanoma	135
Mapping the mediators of Alzheimer’s disease	135
Second international consensus report on gaps and opportunities for the clinical translation of precision diabetes medicine	135
Modeling multiple myeloma heterogeneity in mice to advance therapeutic discoveries	134
The role of placebo control in clinical trials for neurodegenerative diseases	134
Improving scientific integrity in Chinese medical institutions with the Hospital Research Integrity Alliance	134
Blood lipid profiling indicates that dietary fat quality is associated with cardiometabolic risk	133
Biological and health effects of fire smoke exposure	132
Author Correction: Protective autophagy elicited by RAF→MEK→ERK inhibition suggests a treatment strategy for RAS-driven cancers	132
Balancing the risks of HIV transmission at low viral load	132
Boosting the efficacy of emergency contraception	132
Location matters for brain gene therapy in lysosomal disorders	131
Education does not affect memory decline or brain aging	131
Association of step counts over time with the risk of chronic disease in the All of Us Research Program	130
Nivolumab plus chemotherapy or ipilimumab in gastroesophageal cancer: exploratory biomarker analyses of a randomized phase 3 trial	130
Publisher Correction: Trastuzumab deruxtecan in HER2-positive advanced breast cancer with or without brain metastases: a phase 3b/4 trial	130
Anti-GD2 CAR-NKT cells in relapsed or refractory neuroblastoma: updated phase 1 trial interim results	130
Pakistan is failing in maternal and neonatal tetanus elimination	129
Home-based transcranial direct current stimulation treatment for major depressive disorder: a fully remote phase 2 randomized sham-controlled trial	129
Building resilience in heatwaves	128