OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Receptors and Signal Transduction is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
The cannabinoid CB ₂ receptor positive allosteric modulator EC21a exhibits complicated pharmacology in vitro	19
The route of autophagy regulation by osteopontin: a review on the linking mechanisms	16
Molecular insights into voltage-gated sodium channels in excitable cells: pathophysiological roles and emerging therapeutic targets	12
Exploring the composition of protein-ligand binding sites for cancerous inhibitor of PP2A (CIP2A) by inhibitor guided binding analysis: paving a new way for the Discovery of drug candidates against tr	11
TPX2 knockdown mediates p53 activation to induce autophagy and apoptosis for anti-colorectal cancer effects	9
Pharmacophore-based identification and molecular docking of CCR5 inhibitors: insights from dynamic simulations	9
Investigating the causal relationship between immune cells and colorectal cancer risk using bidirectional and multivariable Mendelian randomization analysis	9
Heat shock protein (Hsp27)-ceramide synthase (Cers1) protein-protein interactions provide a new avenue for unexplored anti-cancer mechanism and therapy	8
Regulation of elevated expression of Mcl-1 in hepatocellular carcinoma – a review	8
An overview of the molecular and clinical significance of the angiopoietin system in leukemia	7
Quest for discovering novel CDK12 inhibitor	6
Sepsis modulates aortic AT1 and P₂Y₆ receptors to produce vascular hyporeactivity in mice	6
Identification of novel mycocompounds as inhibitors of PI3K/AKT/mTOR pathway against RCC	6
Computational design, synthesis, and in vitro evaluation of thiadiazole-derived PARP-1 inhibitors	6
Lycopene induces antiproliferative effects through apoptosis, autophagy, and oxidative DNA damage in the HeLa cells	5
Bortezomib suppresses TGF-β1-mediated LOXL4 reduction through the inhibition of MEK/ERK pathways in MDA-MB-231 cells	5
Deciphering the involvement of norepinephrine and β-adrenergic receptor subtypes in glucose induced insulin secretion: an integrated in silico and in vitr	5
Design and molecular mechanism investigation of ALK inhibitors based on virtual screening and structural descriptor modeling	4
Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway	4
Protective effects of salvianolic acid B on intestinal ischemia/reperfusion injury in rats by regulating the AhR/IL-22/STAT6 axis	4
Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE)	4
QSAR study of indole derivatives as active agents against Candida albicans: a DFT calculation	4
Effect of elastin on abnormal proliferation of pulmonary artery smooth muscle cells at an early stage of hypoxic exposure	4
Crosstalk between kisspeptin and gonadotropin-inhibitory hormone in the silence of puberty: preclinical evidence from a calcium signaling study	3
Discrepancies in β-adrenergic receptor signaling and cAMP pathway in high-fat simple carbohydrate diet-fed C57BL/6J mice: implications for metabolic syndrome pathophysiology	3

CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN	3
The influence of senescent associated secretory phenotype on glucose homeostasis in C2C12 muscle cells: insights into potential p38 inhibitor interventions	2
Orphan G-protein coupled receptor 75 (GPR75), a unique and controversial potential therapeutic target	2
Identifying potent Janus kinase 3 inhibitors using structure-guided virtual screening for inflammatory and neoplastic disease therapy	2
The combined use of thymoquinone and metformin provides more effective neuroprotection in a mouse model of MPTP-induced Parkinson’s disease	2
cGAS-STING and PD1/PDL-1 pathway in breast cancer: a window to new therapies	2
An in-silico approach - molecular docking analysis of flavonoids against GSK-3β and TNF-α targets in Alzheimer’s disease	2
The role of G protein-coupled receptor 4 in inflammatory diseases and its potential clinical significance	2
Understanding the association of cell-surface proteins (ACE2 and GRP78) facilitating pathogen recognition: a computational approach	2
4-octyl itaconate inhibits high glucose induced renal tubular epithelial cell fibrosis through TGF-β-ROS pathway	2
Effects of diffusion, affinity, and permeation rate on drug cell therapy	2
Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario	2
Focusing on Keap1, IKKβ, and Bcl2 proteins: predicted targets of stigmasterol in neurodegeneration	2
Targeting vascular endothelial growth factor and its receptors in non-small cell lung cancer for improved treatment strategies	2
Long-term spontaneous membrane currents in DRG neurons	2
MicroRNA-124a regulates the differentiation of bone marrow mesenchymal stem cells into neurons	2
Targeting ubiquitin-specific peptidase 22 (USP22) as a nexus for drug repurposing in anticancer therapeutic development	1
Allosteric covalent inhibition of TOE1 as potential unexplored anti-cancer target: structure-based virtual screening and covalent molecular dynamics analysis	1
Interaction of sex hormone receptors and calcium handling proteins in the left ventricle of patients with heart failure	1
Signaling complexity in diabetic neuropathy: a multitargeted perspective on pathogenesis and therapy	1
In silico investigation of Panchagavya Ghrita’s anticancer potential against glioblastoma: a network pharmacology and molecular docking study	1
Evaluation of the effect of Helicobacter pylori -derived OMVs and released exosomes from stomach cells treated with OMVs on the expression of genes related to the TGF-β/	1
Influencing hair regrowth with EGCG by targeting glycogen synthase kinase-3β activity: a molecular dynamics study	1
Novel therapeutic approaches targeting 5-HT7 receptors outside the central nervous system	1
MFAP2 promotes the malignant progression of gastric cancer via activating the PI3K/AKT signaling pathway	1
Estrogen receptors as potential therapeutic target in endometrial cancer	1
Mechanistic insights into sodium ion-mediated ligand binding affinity and modulation of 5-HT2B GPCR activity: implications for drug discovery and development	1
The vasodilator effect of Eugenol on uterine artery – potential therapeutic applications in pregnancy-associated hypertension	1