OOIR: Observatory of International Research

Papers

(The median citation count of Journal of Receptors and Signal Transduction is 1. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-01-01 to 2026-01-01.)

Article	Citations
The cannabinoid CB ₂ receptor positive allosteric modulator EC21a exhibits complicated pharmacology in vitro	28
Methylglyoxal enhances the proliferation of vascular smooth muscle cells via Akt phosphorylation	24
Endothelial progenitor cells promote neural stem cell proliferation in hypoxic conditions through VEGF via the PI3K/AKT pathway	16
The route of autophagy regulation by osteopontin: a review on the linking mechanisms	15
TPX2 knockdown mediates p53 activation to induce autophagy and apoptosis for anti-colorectal cancer effects	14
Investigating the causal relationship between immune cells and colorectal cancer risk using bidirectional and multivariable Mendelian randomization analysis	13
Exploring the composition of protein-ligand binding sites for cancerous inhibitor of PP2A (CIP2A) by inhibitor guided binding analysis: paving a new way for the Discovery of drug candidates against tr	10
Heat shock protein (Hsp27)-ceramide synthase (Cers1) protein-protein interactions provide a new avenue for unexplored anti-cancer mechanism and therapy	10
Regulation of elevated expression of Mcl-1 in hepatocellular carcinoma – a review	10
Can calcitonin gene-related peptide (CGRP) and pentraxin-3 (PTX-3) be useful in diagnosing acute migraine attack?	9
Identification of novel mycocompounds as inhibitors of PI3K/AKT/mTOR pathway against RCC	7
Quest for discovering novel CDK12 inhibitor	7
An overview of the molecular and clinical significance of the angiopoietin system in leukemia	7
XIST/miR-34a-5p/PDL1 axis regulated the development of lung cancer cells and the immune function of CD8⁺ T cells	7
Bortezomib suppresses TGF-β1-mediated LOXL4 reduction through the inhibition of MEK/ERK pathways in MDA-MB-231 cells	6
Rhein protects retinal Müller cells from high glucose-induced injury via activating the AMPK/Sirt1/PGC-1α pathway	5
Lycopene induces antiproliferative effects through apoptosis, autophagy, and oxidative DNA damage in the HeLa cells	5
MiR-370-5p inhibits the progression of breast cancer via targeting LUC7L3	5
Sepsis modulates aortic AT1 and P₂Y₆ receptors to produce vascular hyporeactivity in mice	5
Molecular docking and toxicity studies of nerve agents against acetylcholinesterase (AChE)	5
Deciphering the involvement of norepinephrine and β-adrenergic receptor subtypes in glucose induced insulin secretion: an integrated in silico and in vitr	5
Effect of elastin on abnormal proliferation of pulmonary artery smooth muscle cells at an early stage of hypoxic exposure	5
QSAR study of indole derivatives as active agents against Candida albicans: a DFT calculation	4
Design and molecular mechanism investigation of ALK inhibitors based on virtual screening and structural descriptor modeling	4
Crosstalk between kisspeptin and gonadotropin-inhibitory hormone in the silence of puberty: preclinical evidence from a calcium signaling study	4

Protective effects of salvianolic acid B on intestinal ischemia/reperfusion injury in rats by regulating the AhR/IL-22/STAT6 axis	4
The influence of senescent associated secretory phenotype on glucose homeostasis in C2C12 muscle cells: insights into potential p38 inhibitor interventions	3
CBLC inhibits the proliferation and metastasis of breast cancer cells via ubiquitination and degradation of CTTN	3
Preeclamptic plasma disrupts endothelial function and promotes inflammation in endothelial cells: beneficial effects of glibenclamide and MCC950 in this scenario	3
Understanding the association of cell-surface proteins (ACE2 and GRP78) facilitating pathogen recognition: a computational approach	3
Orphan G-protein coupled receptor 75 (GPR75), a unique and controversial potential therapeutic target	2
Identifying potent Janus kinase 3 inhibitors using structure-guided virtual screening for inflammatory and neoplastic disease therapy	2
Long-term spontaneous membrane currents in DRG neurons	2
Focusing on Keap1, IKKβ, and Bcl2 proteins: predicted targets of stigmasterol in neurodegeneration	2
The role of G protein-coupled receptor 4 in inflammatory diseases and its potential clinical significance	2
4-octyl itaconate inhibits high glucose induced renal tubular epithelial cell fibrosis through TGF-β-ROS pathway	2
QSAR study of antituberculosis activity of oxadiazole derivatives using DFT calculations	2
An in-silico approach - molecular docking analysis of flavonoids against GSK-3β and TNF-α targets in Alzheimer’s disease	2
Selective thyroid hormone receptor beta agonist, GC-1, is capable to reduce growth of colorectal tumor in syngeneic mouse models	2
The combined use of thymoquinone and metformin provides more effective neuroprotection in a mouse model of MPTP-induced Parkinson’s disease	2
Targeting ubiquitin-specific peptidase 22 (USP22) as a nexus for drug repurposing in anticancer therapeutic development	1
Influencing hair regrowth with EGCG by targeting glycogen synthase kinase-3β activity: a molecular dynamics study	1
Interaction of sex hormone receptors and calcium handling proteins in the left ventricle of patients with heart failure	1
UBE2C, targeted by miR-140-3p, promotes the progression of osteosarcoma via PI3K/AKT signaling pathway	1
cGAS-STING and PD1/PDL-1 pathway in breast cancer: a window to new therapies	1
Signaling complexity in diabetic neuropathy: a multitargeted perspective on pathogenesis and therapy	1
Novel therapeutic approaches targeting 5-HT7 receptors outside the central nervous system	1
A novel anticancer candidate, coumarin-3-carboxamide derivative inhibits cell proliferation and migration in MDA-MB-231 cell line	1
Evaluation of the effect of Helicobacter pylori -derived OMVs and released exosomes from stomach cells treated with OMVs on the expression of genes related to the TGF-β/	1
Allosteric covalent inhibition of TOE1 as potential unexplored anti-cancer target: structure-based virtual screening and covalent molecular dynamics analysis	1
MicroRNA-124a regulates the differentiation of bone marrow mesenchymal stem cells into neurons	1
MFAP2 promotes the malignant progression of gastric cancer via activating the PI3K/AKT signaling pathway	1
The vasodilator effect of Eugenol on uterine artery – potential therapeutic applications in pregnancy-associated hypertension	1
Identification of novel lead molecules against the EGFR kinase domain using structure-based virtual screening, molecular docking, and molecular dynamics simulations	1
Mechanistic insights into sodium ion-mediated ligand binding affinity and modulation of 5-HT2B GPCR activity: implications for drug discovery and development	1
Target-based in-silico screening of basil polysaccharides against different epigenetic targets responsible for breast cancer	1
Estrogen receptors as potential therapeutic target in endometrial cancer	1