OOIR: Observatory of International Research

Papers

(The TQCC of Journal of Investigative Medicine is 4. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
CIAP1/2 can regulate the inflammatory response and lung injury induced by apoptosis in septic rats	159
The scientific value of medical student research: The experience at the Arrow Program for Medical Research Education	111
Stem bark of Fraxinus rhynchophylla ameliorates the severity of pancreatic fibrosis by regulating the TGF-β/Smad signaling pathway	103
Institutionally Chartered Data and Safety Monitoring Boards: Structured Approaches to Assuring Participant Safety in Clinical Research	42
Basic Fibroblast Growth Factor Inhibits Aortic Valvular Interstitial Cells Calcification via Notch1 Pathway	41
Circulating lipid and lipoprotein profiles and their correlation to cardiac function and cardiovascular outcomes in patients with acute myocardial infarction	38
Telomere Length in Patients with Alcohol-Associated Liver Disease: A Brief Report	33
The prevalence and characteristics of misinformation on “TikTok” related to cirrhosis and liver disease: A comparative analysis of accurate and misleading content	29
Diagnostic role of multislice spiral computed tomography combined with clinical manifestations and laboratory tests in acute appendicitis subtypes	28
EXPRESS: CircZFR involves propofol-triggered ferroptosis in lung cancer cells through the IGF2BP2/GPX4 axis	25
Does anticoagulation in combination with immunosuppressive therapy prevent recurrent thrombosis in Behçet’s disease?	24
The Data Error Criteria (DEC) for retrospective studies: development and preliminary application	24
Colonoscopy in the young: Rethinking the yield	22
The role of pentraxin 3 and oxidative status in the prognosis of multiple myeloma	20
Hyperbilirubinemia in hospitalized patients: Etiology and outcomes	20
Non-Surgical Animal Model of Gastroesophageal Reflux Disease by Overeating Induced in Mice	20
COVID-19-related mortality in Texas border counties vs non-border counties	18
Evaluation of Glycemic Control in Critically ill Patients with Bacteremia: A Retrospective, Single-Center Cohort Study	18
COVID-19 Pneumonia in Patients with Impaired Fasting Glucose, Newly Diagnosed Diabetes and Pre-Existing Diabetes: A Tertiary Center Experience	16
Response to “Comment on ‘Clopidogrel can be an Effective Complementary Prophylactic for Drug-Refractory Migraine with Patent Foramen Ovale’”	16
Tocilizumab in Patients Hospitalized with COVID-19 Pneumonia: Systematic Review and Meta-Analysis of Randomized Controlled Trials	16
Magnesium intake is associated with the metabolically healthy obese phenotype	15
FK-binding protein 5: Possible relevance to the pathogenesis of metabolic dysfunction and alcohol-associated liver disease	15
Importance of beta-lactam pharmacokinetics and pharmacodynamics on the recovery of microbial diversity in the airway of persons with cystic fibrosis	15
Insulin Doses Requirements in Patients with Type 1 Diabetes Using Glargine U300 or Degludec in Routine Clinical Practice	15

Relationship between circulating serum omentin-1 levels and nascent metabolic syndrome in patients with hypertension	15
2022 Southern Medical Research Conference	14
Analysis of risk factors for abdominal aortic calcification in dialysis patients and its influence on long-term recovery	14
Human microglia polarization following infection with the Lyme disease spirochete	14
Serum Talin-1 and Pentraxin-3 levels as biomarkers for vulnerable plaques in STEMI: Correlation with SYNTAX and Gensini scores	14
Yet Another Amyloidosis	13
Bifidobacterium bifidum BGN4 fractions ameliorate palmitic acid-induced hepatocyte ferroptosis by inhibiting SREBP1-CYP2E1 pathway	13
EXPRESS: Effect of insulin aspart combined with insulin detemir and metformin on islet function in newly diagnosed type 2 diabetes mellitus	13
Combined treatment with ruxolitinib and MK-2206 inhibits ERα activity by inhibiting MAPK signaling in BT474 breast cancer cells	12
Deferasirox Combination with Eltrombopag Shows Anti-Myelodysplastic Syndrome Effects by Enhancing iron Deprivation–Related Apoptosis	12
Clinical characteristics, prognostic factors, and outcomes of ventricular septal rupture in patients with acute myocardial infarction	12
An innovative approach to comprehensive communication skills training for residents: A resident-led communication curriculum	12
Bronchodilatory Effect of Higenamine as Antiallergic Asthma Treatment	11
Inhaled corticosteroids on mortality in COVID-19: A systematic review and meta-analysis of randomized controlled trials	11
Serum liver enzymes and metabolic syndrome from the Rafsanjan Cohort Study	11
COVID-19 in the intensive care unit: Unmasking the critical factors impacting patient survival	11
Trends and Demographic Patterns in Biologic and Corticosteroid Prescriptions for Inflammatory Bowel Disease: Findings from Electronic Medical Records, 2011–2020	11
MEF2A restrains cisplatin resistance in gastric cancer cells by modulating NFKBIA/NF-κB signaling pathway	11
Introduction of 2024 International Conference on Advances in Biological Science and Technology, September 28-30, 2024, Online Video Conference	11
Patient perception of voxelotor treatment benefit in sickle cell disease	10
Historical view of medical Spanish instruction in a medical school at the US–Mexico border region	10
Utility of Serum Neuropilin-1 and Angiopoietin-2 as Markers of Hepatocellular Carcinoma	10
Cancer Immunotherapy in Adult Patients with HIV	10
Mitochondria Signaling Pathways in Allergic Asthma	9
LECT-2 Amyloidosis: What do we Know?	9
Predictors of misperceptions, risk perceptions, and personal risk perceptions about COVID-19 by country, education and income	9
EXPRESS: Beyond age and family history: Symptoms as predictors in colorectal cancer screening	9
Dynamic Albumin Values as Clinical Surrogate for Covid-19 Therapeutics	9
Epidemiology, diagnosis, and management of cardiac amyloidosis	9
Response to: Faculty should be cautiously optimistic about the role of generative AI in medical education	9
Latin Americans and US Hispanics show Differences in IBD Phenotype: A Systematic Review with Meta-Analysis	9
Expanded hemodialysis: a new concept of renal replacement therapy	8
The role of immune activation and antigen persistence in acute and long COVID	8
Liver fibrosis prediction models in a population of Latina and White women	8
Normal saline vs balanced intravenous fluids in acute ischemic stroke: A retrospective study	8
Clinical characteristics and social determinants of health associated with 30-day hospital readmissions of patients with COVID-19	8
Network analysis of genes associated with esophageal squamous cell carcinoma progression	8
Metabolic Derangement in Patients with Vitiligo: A Cross-Sectional Study	8
Clinical differences in symptomology, characteristics, and risk factors in patients with post-acute sequelae of COVID-19: an experience from a tertiary-care academic center	8
Current status of novel weight loss interventions	8
Study of antibiotic resistance and virulence genes in Escherichia coli isolated from urinary tract infection patients in Tanta University Hospitals	8
Comparison of outcome among type 2 vs type 1 myocardial infarction: a systematic review and meta-analysis	8
The association of systemic lupus erythematosus with short-term mortality in sepsis: a population-level analysis	8
Evaluation of thiol–disulfide homeostasis and oxidative stress parameters in newborns receiving phototherapy	8
Venous Capacitance and Venous Return in Young Adults with Typical Vasovagal Syncope: A Cross-Sectional Study	8
Bleeding Ectopic Varices: Clinical Presentation, Natural History, and Outcomes	8
Applicant essays and recommendation letters in residency selection:How generative artificial intelligence is changing them	7
Comparing the Effects of Twice-Daily Exenatide and Insulin on Renal Function in Patients with Type 2 Diabetes Mellitus: Secondary Analysis of a Randomized Controlled Trial	7
Effects of non-surgical treatment of chronic periodontitis on insulin resistance and glucose tolerance in subjects without diabetes (PARODIA 2 study)	7
Association between monocyte to high-density lipoprotein-cholesterol ratio and osteoporosis: An analysis of the National Health and Nutrition Examination Survey 2013–2014	7

Association of intermittent versus continuous hemodialysis modalities with mortality in the setting of acute stroke among patients with end-stage renal disease	7
Fauci Effect? When the Heart is in the Right Place, but Reality is Not	7
Depressive Symptomatology in Adults during the COVID-19 Pandemic	7
Wegovy (Semaglutide): A New Weight Loss Drug for Chronic Weight Management	7
Health insurance prevalence and acute pancreatitis mortality: a cross-sectional analysis	7
COVID-19’s immuno-pathology and cardiovascular diseases	7
Management of deep neck infections in adults and importance of clinical and laboratory findings	7
EXPRESS: Peripheral ICOS+CD4 T cell frequency: an indicator for short-term progression in resectable advanced gastric cancer following platinum-based chemotherapy	7
Postchallenge Glucose Increment Was Associated with Hemoglobin Glycation Index in Subjects with No History of Diabetes	7
Translational science and related disciplines	7
Sex Differences in the Induction of Angiotensin Converting Enzyme 2 (Ace-2) in Mouse Lungs after E-Cigarette Vapor Exposure and Its Relevance to Covid-19	7
The effect of over- and undertreatment of hypothyroidism on hospitalization outcomes of patients with decompensated heart failure	6
Serum Levels of IL-37 and Correlation with Inflammatory Cytokines and Clinical Outcomes in Patients with Coronary Artery Disease	6
Autophagy and Cancer Metastasis: A Trojan Horse	6
EXPRESS: Nasopharyngeal Airway-Assisted Sedation Enhances Oxygenation and Reduces Perioperative Adverse Events in Pediatric Dental Surgery: A Comparative Clinical Study	6
Incidence and Risk Factors for Mucormycosis in Renal Transplant Patients	6
Direct-to-patient telemedicine: Expanding access to regional pediatric specialty care	6
Effect of Bisphosphonate on Hip Fracture in Patients with Osteoporosis or Osteopenia According to age: A Meta-Analysis and Systematic Review	6
Natriuretic Peptides, Extracellular Volume, and Subclinical Cardiovascular Changes in Chronic Kidney Disease Stages 1–3: A Pilot Study	6
Glucose ingestion does not lower testosterone concentrations in men on testosterone therapy	6
Cannabinoid hyperemesis syndrome: prevalence and management in an era of cannabis legalization	6
Prediction of overall survival after radical gastrectomy using nomograms created by tumor markers	6
Response to: Applicant essays and recommendation letters in residency selection: How generative artificial intelligence is changing them	6
Cholesterol deficiency as a mechanism for autism: A valproic acid model	6
Response to: Correspondence on ‘Prospective Predictive Performance Comparison between Clinical Gestalt and Validated COVID-19 Mortality Scores’ by Meza-Comparán	5
Assessing the causal relationship between obesity and hypothyroidism using Mendelian randomization	5
Association of exposure to nonpersistent endocrine disruptors with sex hormones and metabolic health in US females	5
Dual-specificity phosphatase 8 (DUSP8) induces drug resistance in breast cancer by regulating MAPK pathways	5
Epidemiological and Clinical Characteristics of Non-Severe and Severe Pediatric and Adult COVID-19 Patients across Different Geographical Regions in the Early Phase of Pandemic: A Systematic Review an	5
Implementation of telepsychiatry in an urban pediatric satellite emergency department	5
Screening for presence of primary Sjogren’s syndrome in patients with autoimmune thyroid diseases	5
Retrospective Evaluation of Patients with and without 14-Day Readmissions following Hospitalization for COVID-19	5
In-vivo Skeletal Muscle Mitochondrial Function in Klinefelter Syndrome	5
Rapid qPCR-based quantitative immune cell phenotyping in mouse tissues	5
Cohen's d and Physicians’ Opinion on Effect Size: A Questionnaire on Anemia Treatment	5
Outcomes of beta-blocker therapy in methamphetamine users with cardiovascular conditions	5
Correspondence on “Prognostic significance of complement factors in severely ill patients with COVID-19”	5
Comparing Patient Characteristics and Outcomes in Type 1 versus Type 2 Diabetes with Diabetic Ketoacidosis: A Review and a Propensity-Matched Nationwide Analysis	5
Author Index	5
Patterns and seasonality in pediatric referrals for functional somatic symptoms	5
Effects of prehabilitation resistance training in mild to moderate clinically frail patients awaiting coronary artery bypass graft surgery	5
EXPRESS: Spexin as a Potential Biomarker for Autoimmune Inflammation in Graves’ Disease	5
Challenging biological samples and strategies for DNA extraction	5
Reflections on my presidency of American Federation of Medical Research (AFMR)	4
Butylphthalide protects against ischemia-reperfusion injury in rats via reducing neuron ferroptosis and oxidative stress	4
Protective effect of Shenfu on gut epithelium in a porcine model of hemorrhagic shock	4
Understanding the association between admission source and in-hospital delirium: A cross-sectional study	4
Study of role of melanoma-associated antigen D1 (MAGE-D1) in hepatocellular carcinoma	4
The incidence and characteristics of giant cell arteritis in Hispanics and the associated outcomes of ischemic ocular events and stroke	4
Timing of convalescent plasma administration and 28-day mortality in COVID-19 pneumonia	4
Specific Changes of Erythroid Regulators and Hepcidin in Patients Infected by SARS-COV-2	4
Single-center outcomes of artificial intelligence in management of pulmonary embolism and pulmonary embolism response team activation	4
Sequential administration of pemetrexed and cisplatin reprograms tumor immune microenvironment and potentiates PD-1/PD-L1 treatment in a lung cancer model	4
Correlation of Rate of Serum Albumin Decline with other Acute Phase Reactants and Effect of Current Treatment Options on Serum Albumin Level in Covid-19	4
AFMR Southeastern Regional Meeting Supplement	4
Comparison of clinicopathological characteristics and response to neoadjuvant systemic therapy in patients with HER2-low-positive and HER2-zero breast cancer	4
Ambulatory Cardiology Telemedicine: A Large Academic Pediatric Center Experience	4
Severe COVID-19-associated hyperinflammatory syndrome versus classic hemophagocytic lymphohistiocytosis: similarities, differences, and the way forward	4
GANT61, an inhibitor of Gli1, inhibits the proliferation and migration of hepatocellular carcinoma cells	4
A new therapeutic perspective: Erastin inhibits tumor progression by driving ferroptosis in myelodysplastic syndromes	4
A novel predictive model based on pericarotid adipose tissue and lumen stenosis for stroke risk in patients with asymptomatic carotid stenosis	4
Semaglutide 2.4 Mg: The Latest GLP-1RA Approved for Obesity	4
Association between Blood Carboxyhemoglobin Level and Bronchopulmonary Dysplasia in Extremely Low Birthweight Infants	4
Clinical predictions of COVID-19 patients using deep stacking neural networks	4
Abstracts	4
EXPRESS: Assessment of serum level of galectin-9 in systemic lupus erythematosus patients in Tanta university hospitals	4
Hematological ratios in coronavirus disease 2019 patients with and without invasive mechanical ventilation	4
Strengthening research capacity of early-mid career researchers: Implementation and evaluation of the Excellence in Non-COmmunicable disease REsearch (ENCORE) program	4
Association between nonalcoholic fatty liver disease and atrial fibrillation and other clinical outcomes: a meta-analysis	4
Trends of Sources of Clinical Research Funding from 1990 to 2020: A Meta-Epidemiological Study	4
State of the art: Alternative overlap syndrome—asthma and obstructive sleep apnea	4
Prevalence, outcomes, and complications of vitamin D deficiency among patients with multiple myeloma: Nationwide burden of disease	4
N-Terminal Pro-Brain Natriuretic Peptide is an Independent Predictor of Mortality in Patients with Sepsis	4
Construction and validation of an autophagy-related long non-coding RNA signature to predict the prognosis of kidney renal papillary cell carcinoma	4
Correspondence on ‘Role of AMPK/mTOR-independent autophagy in clear cell renal cell carcinoma’ by Radovanovic et al	4
Treatment and Outcomes among Patients ≥85 Years Hospitalized with Community-Acquired Pneumonia	4
Public health initiatives: Addressing social vulnerability in research and practice	4
Effect of intramuscular depot betamethasone injection in patients with fibromyalgia and elevated C-reactive protein levels	4
Pharmacokinetic advantages of lipophilic statins over rosuvastatin in COVID-19 management	4
Overview of Severe Asthma, with Emphasis on Pediatric Patients: A Review for Practitioners	4