Journal of Biomedical Optics

Article	Citations
Fluorescence lifetime imaging microscopy: fundamentals and advances in instrumentation, analysis, and applications	387
Terahertz radiation and the skin: a review	85
Deep learning in photoacoustic tomography: current approaches and future directions	85
Comprehensive review of surgical microscopes: technology development and medical applications	53
Beer–Lambert law for optical tissue diagnostics: current state of the art and the main limitations	51
Automatic detection of oral cancer in smartphone-based images using deep learning for early diagnosis	50
Photogrammetry-based stereoscopic optode registration method for functional near-infrared spectroscopy	49
Cellular effects of terahertz waves	48
Smartphone-based imaging systems for medical applications: a critical review	46
Diffuse correlation spectroscopy measurements of blood flow using 1064 nm light	41
Deep learning in photoacoustic imaging: a review	41
Rise of Raman spectroscopy in neurosurgery: a review	39
Laparoscopic system for simultaneous high-resolution video and rapid hyperspectral imaging in the visible and near-infrared spectral range	34
Toward accurate quantitative photoacoustic imaging: learning vascular blood oxygen saturation in three dimensions	33
Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography	32
Indocyanine green matching phantom for fluorescence-guided surgery imaging system characterization and performance assessment	31
Recent innovations in fluorescence lifetime imaging microscopy for biology and medicine	28
GPU implementation of photoacoustic short-lag spatial coherence imaging for improved image-guided interventions	27
Heartbeat OCE: corneal biomechanical response to simulated heartbeat pulsation measured by optical coherence elastography	26
Interpretable deep learning approach for oral cancer classification using guided attention inference network	26
Optical manipulation: advances for biophotonics in the 21st century	25
Perspective on fast-evolving photoacoustic tomography	25
Surface-enhanced Raman spectroscopy of tears: toward a diagnostic tool for neurodegenerative disease identification	25
Fast pulsatile blood flow measurement in deep tissue through a multimode detection fiber	24
Validation of diffuse correlation spectroscopy measures of critical closing pressure against transcranial Doppler ultrasound in stroke patients	24

Mobile-based oral cancer classification for point-of-care screening	24
Mapping cisplatin-induced viscosity alterations in cancer cells using molecular rotor and fluorescence lifetime imaging microscopy	23
Kernel Flow: a high channel count scalable time-domain functional near-infrared spectroscopy system	23
Saliva-based detection of COVID-19 infection in a real-world setting using reagent-free Raman spectroscopy and machine learning	23
Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings	22
Clinical evaluation of fever-screening thermography: impact of consensus guidelines and facial measurement location	21
Heartbeat optical coherence elastography: corneal biomechanics in vivo	21
Characterization of Mueller matrix elements for classifying human skin cancer utilizing random forest algorithm	21
Role of scattering and birefringence in phase retardation revealed by locus of Stokes vector on Poincaré sphere	20
Hemoglobin quantification in red blood cells via dry mass mapping based on UV absorption	19
Gastric cancer diagnosis using hyperspectral imaging with principal component analysis and spectral angle mapper	19
HRVCam: robust camera-based measurement of heart rate variability	19
MCX Cloud—a modern, scalable, high-performance and in-browser Monte Carlo simulation platform with cloud computing	19
Deep feature loss to denoise OCT images using deep neural networks	19
Perspective on the increasing role of optical wearables and remote patient monitoring in the COVID-19 era and beyond	19
Interferometric diffuse correlation spectroscopy improves measurements at long source–detector separation and low photon count rate	18
Effective photoacoustic absorption spectrum for collagen-based tissue imaging	18
Tutorial on laser speckle rheology: technology, applications, and opportunities	18
Machine learning for direct oxygen saturation and hemoglobin concentration assessment using diffuse reflectance spectroscopy	18
Point-of-care, multispectral, smartphone-based dermascopes for dermal lesion screening and erythema monitoring	18
Oligonucleotide conjugated antibodies permit highly multiplexed immunofluorescence for future use in clinical histopathology	17
Automatic detection and characterization of quantitative phase images of thalassemic red blood cells using a mask region-based convolutional neural network	17
Wave of single-impulse-stimulated fast initial dip in single vessels of mouse brains imaged by high-speed functional photoacoustic microscopy	17
Intraoperative fluorescence perfusion assessment should be corrected by a measured subject-specific arterial input function	17
Characterizing reduced scattering coefficient of normal human skin across different anatomic locations and Fitzpatrick skin types using spatial frequency domain imaging	17
Review of successful pathways for regulatory approvals in open-field fluorescence-guided surgery	17
Machine learning to extract physiological parameters from multispectral diffuse reflectance spectroscopy	16
Classification of imbalanced oral cancer image data from high-risk population	16
Hollow core photonic crystal fiber-assisted Raman spectroscopy as a tool for the detection of Alzheimer’s disease biomarkers	16
Aptamer-based surface-enhanced resonance Raman scattering assay on a paper fluidic platform for detection of cardiac troponin I	16
High signal-to-noise ratio reconstruction of low bit-depth optical coherence tomography using deep learning	16
Automatic diagnosis of macular diseases from OCT volume based on its two-dimensional feature map and convolutional neural network with attention mechanism	16
Modulation frequency selection and efficient look-up table inversion for frequency domain diffuse optical spectroscopy	15
Diagnosing 12 prostate needle cores within an hour of biopsy via open-top light-sheet microscopy	15
Review of consensus test methods in medical imaging and current practices in photoacoustic image quality assessment	15
Binary photoacoustic tomography for improved vasculature imaging	15
Handheld optical coherence tomography for clinical assessment of dental plaque and gingiva	14
Photoacoustics resolves species-specific differences in hemoglobin concentration and oxygenation	14
Deep learning methods hold promise for light fluence compensation in three-dimensional optoacoustic imaging	14
Wavelength- and irradiance-dependent changes in intracellular nitric oxide level	14
Evaluation of the optical and biomechanical properties of bioengineered human skin generated with fibrin-agarose biomaterials	14
Design and implementation of a portable colposcope Mueller matrix polarimeter	14
Effects of lipid composition on photothermal optical coherence tomography signals	14
Deep learning in macroscopic diffuse optical imaging	13
In vivo microscopy as an adjunctive tool to guide detection, diagnosis, and treatment	13
Virtual scale function of gastrointestinal endoscopy for accurate polyp size estimation in real-time: a preliminary study	13
Effects of patient-specific treatment planning on eligibility for photodynamic therapy of deep tissue abscess cavities: retrospective Monte Carlo simulation study	13
Image-guided Raman spectroscopy probe-tracking for tumor margin delineation	13
Dose-response analysis of microvasculature changes in the murine fetal brain and the maternal extremities due to prenatal ethanol exposure	13
Quantitative evaluation of frequency domain measurements in high density diffuse optical tomography	13

Estimation of skin microcirculatory hemoglobin oxygen saturation and red blood cell tissue fraction using a multispectral snapshot imaging system: a validation study	12
Characterization of retinal biomechanical properties using Brillouin microscopy	12
Measuring hemoglobin spectra: searching for carbamino-hemoglobin	12
Looking for a perfect match: multimodal combinations of Raman spectroscopy for biomedical applications	12
Separation of color channels from conventional colonoscopy images improves deep neural network detection of polyps	12
Rapid tissue oxygenation mapping from snapshot structured-light images with adversarial deep learning	12
Compact and ultracompact spectral imagers: technology and applications in biomedical imaging	12
Open-sourced Raman spectroscopy data processing package implementing a baseline removal algorithm validated from multiple datasets acquired in human tissue and biofluids	12
Hyperspectral and multispectral image processing for gross-level tumor detection in skin lesions: a systematic review	12
Label-free imaging of lipid-rich biological tissues by mid-infrared photoacoustic microscopy	12
Handheld macroscopic Raman spectroscopy imaging instrument for machine-learning-based molecular tissue margins characterization	12
Advantages of Fresnel biprism-based digital holographic microscopy in quantitative phase imaging	11
Anthropomorphic optical phantom of the neonatal thorax: a key tool for pulmonary studies in preterm infants	11
Photoacoustic imaging on its way toward clinical utility: a tutorial review focusing on practical application in medicine	11
Unbiased corneal tissue analysis using Gabor-domain optical coherence microscopy and machine learning for automatic segmentation of corneal endothelial cells	11
Review of in vivo optical molecular imaging and sensing from x-ray excitation	11
Detection of live breast cancer cells in bright-field microscopy images containing white blood cells by image analysis and deep learning	11
Rapid assessment of breast tumor margins using deep ultraviolet fluorescence scanning microscopy	11
SIMPA: an open-source toolkit for simulation and image processing for photonics and acoustics	11
Photoacoustic image improvement based on a combination of sparse coding and filtering	11
Deep learning-level melanoma detection by interpretable machine learning and imaging biomarker cues	11
Patient-derived cancer organoid tracking with wide-field one-photon redox imaging to assess treatment response	11
Multiresolution nondestructive 3D pathology of whole lymph nodes for breast cancer staging	10
Constructing a portable optical polarimetry probe for in-vivo skin cancer detection	10
Live mechanistic assessment of localized cardiac pumping in mammalian tubular embryonic heart	10
Development of oral cancer tissue-mimicking phantom based on polyvinyl chloride plastisol and graphite for terahertz frequencies	10
Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets	10
Sub-millimeter endoscope demonstrates feasibility of in vivo reflectance imaging, fluorescence imaging, and cell collection in the fallopian tubes	10
High-speed axially swept light sheet microscopy using a linear MEMS phased array for isotropic resolution	10
Human embryonic stem cell classification: random network with autoencoded feature extractor	10
Automated classification of coronary plaque calcification in OCT pullbacks with 3D deep neural networks	10
Photoacoustic topography through an ergodic relay for functional imaging and biometric application in vivo	10
Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise	10
Polydimethylsiloxane tissue-mimicking phantoms with tunable optical properties	10
Comparison of different spectral cameras for image-guided organ transplantation	9
Research on the combination of color channels in heart rate measurement based on photoplethysmography imaging	9
Deep-learning approach for automated thickness measurement of epithelial tissue and scab using optical coherence tomography	9
Multicontrast investigation of in vivo wildtype zebrafish in three development stages using polarization-sensitive optical coherence tomography	9
Systematic stability testing of insulins as representative biopharmaceuticals using ATR FTIR-spectroscopy with focus on quality assurance	9
Extracellular pH affects the fluorescence lifetimes of metabolic co-factors	9
Domain adaptation for robust workload level alignment between sessions and subjects using fNIRS	9
Polarimetric imaging for cervical pre-cancer screening aided by machine learning: ex vivo studies	9
Development of a Monte Carlo-wave model to simulate time domain diffuse correlation spectroscopy measurements from first principles	9
Dynamic SWIR imaging near the 1950-nm water absorption band for caries lesion diagnosis	9
Photoacoustic imaging for cutaneous melanoma assessment: a comprehensive review	8
Terahertz spectroscopy analysis of human corneal sublayers	8
Image-guided Raman spectroscopy navigation system to improve transperineal prostate cancer detection. Part 1: Raman spectroscopy fiber-optics system and in situ tissue characterization	8
Scalable and accessible personalized photodynamic therapy optimization with FullMonte and PDT-SPACE	8
Photoacoustic imaging of posterior periodontal pocket using a commercial hockey-stick transducer	8
Noninvasive hemoglobin sensing and imaging: optical tools for disease diagnosis	8
Effect of curvature correction on parameters extracted from hyperspectral images	8
Graphics-processing-unit-accelerated Monte Carlo simulation of polarized light in complex three-dimensional media	8
Looking deep inside tissue with photoacoustic molecular probes: a review	8
Simultaneous measurements of tissue blood flow and oxygenation using a wearable fiber-free optical sensor	8
Deep learning-based method to accurately estimate breast tissue optical properties in the presence of the chest wall	8
Hyperspectral imaging for tumor segmentation on pigmented skin lesions	8
History of Monte Carlo modeling of light transport in tissues using mcml.c	8
Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast	8
Portable low-cost macroscopic mapping system for all-optical cardiac electrophysiology	8
Real-time visualization of renal microperfusion using laser speckle contrast imaging	8
Monte Carlo-based data generation for efficient deep learning reconstruction of macroscopic diffuse optical tomography and topography applications	8
MCCL: an open-source software application for Monte Carlo simulations of radiative transport	8
Development of a drug–device combination for fluorescence-guided surgery in neuroendocrine tumors	8
Real-time video-rate perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning	8
Non-invasive blood glucose sensing by machine learning of optic fiber-based speckle pattern variation	8
Perspective on the integration of optical sensing into orthopedic surgical devices	8
Detection of hypoxia by near-infrared spectroscopy and pulse oximetry: a comparative study	8
Image-guided Raman spectroscopy navigation system to improve transperineal prostate cancer detection. Part 2: in-vivo tumor-targeting using a classification model combining spectral and MRI-radiomics	8
Small molecule kinase inhibitors enhance aminolevulinic acid-mediated protoporphyrin IX fluorescence and PDT response in triple negative breast cancer cell lines	8
Multi-reference global registration of individual A-lines in adaptive optics optical coherence tomography retinal images	8
Quantifying tissue optical properties of human heads in vivo using continuous-wave near-infrared spectroscopy and subject-specific three-dimensional Monte Carlo models	7
Intraoperative molecular imaging: 3rd biennial clinical trials update	7
Comparison of preprocessing techniques to reduce nontissue-related variations in hyperspectral reflectance imaging	7
Multiple illumination learned spectral decoloring for quantitative optoacoustic oximetry imaging	7
Modeling toolchain for realistic simulation of photoacoustic data acquisition	7
High-throughput label-free cell detection and counting from diffraction patterns with deep fully convolutional neural networks	7
Applications of compressive sensing in spatial frequency domain imaging	7
Special Section Guest Editorial: Advances in Terahertz Biomedical Science and Applications	7
Experimental validation of a recently developed model for single-fiber reflectance spectroscopy	7
Multiwavelength tissue-mimicking phantoms with tunable vessel pulsation	7

High frame rate (∼3 Hz) circular photoacoustic tomography using single-element ultrasound transducer aided with deep learning	7
First-in-human pilot study of snapshot multispectral endoscopy for early detection of Barrett’s-related neoplasia	7
MCDataset: a public reference dataset of Monte Carlo simulated quantities for multilayered and voxelated tissues computed by massively parallel PyXOpto Python package	7
Focused x-ray luminescence imaging system for small animals based on a rotary gantry	7
Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging	7
Transcutaneous monitoring of hemoglobin derivatives during methemoglobinemia in rats using spectral diffuse reflectance	7
Registration of polarimetric images for in vivo skin diagnostics	7
Label-free detection of brain tumors in a 9L gliosarcoma rat model using stimulated Raman scattering-spectroscopic optical coherence tomography	7
First in patient assessment of brain tumor infiltrative margins using simultaneous time-resolved measurements of 5-ALA-induced PpIX fluorescence and tissue autofluorescence	7
Neural network model assisted Fourier ptychography with Zernike aberration recovery and total variation constraint	7
BlenderPhotonics: an integrated open-source software environment for three-dimensional meshing and photon simulations in complex tissues	7
Accurate and early prediction of the wound healing outcome of burn injuries using the wavelet Shannon entropy of terahertz time-domain waveforms	7
Mueller-matrix imaging polarimetry elevated by wavelet decomposition and polarization-singular processing for analysis of specific cancerous tissue pathology	7
Virtual organelle self-coding for fluorescence imaging via adversarial learning	7
Ultralow energy photoacoustic microscopy for ocular imaging in vivo	7
Tunable blood oxygenation in the vascular anatomy of a semi-anthropomorphic photoacoustic breast phantom	7
Evaluation of visible diffuse reflectance spectroscopy in liver tissue: validation of tissue saturations using extracorporeal circulation	7
Quantifying optical anisotropy in soft tissue membranes using Mueller matrix imaging	7
Prediction of optimal contrast times post-imaging agent administration to inform personalized fluorescence-guided surgery	7
Quantifying the effects of biopsy fixation and staining panel design on automatic instance segmentation of immune cells in human lupus nephritis	7
Optical fibers for endoscopic high-power Er:YAG laserosteotomy	7
Signal-carrying speckle in optical coherence tomography: a methodological review on biomedical applications	7
Near-infrared diffuse in vivo flow cytometry	6
Three-dimensional vascular and metabolic imaging using inverted autofluorescence	6
In situ terahertz monitoring of an ice ball formation during tissue cryosurgery: a feasibility test	6
In situ Raman spectroscopy and machine learning unveil biomolecular alterations in invasive breast cancer	6
Breast cancer differential diagnosis using diffuse optical spectroscopic imaging and regression with z-score normalized data	6
Imaging sub-diffuse optical properties of cancerous and normal skin tissue using machine learning-aided spatial frequency domain imaging	6
Dual short wavelength infrared transillumination/reflectance mode imaging for caries detection	6
Characterization and identification of cell death dynamics by quantitative phase imaging	6
Multispectral snapshot imaging of skin microcirculatory hemoglobin oxygen saturation using artificial neural networks trained on in vivo data	6
Depth distributions of bacteria for the Pseudomonas aeruginosa-infected burn wounds treated by methylene blue-mediated photodynamic therapy in rats: effects of additives to photosensitizer	6
Mid-infrared absorption by soft tissue sarcoma and cell ablation utilizing a mid-infrared interband cascade laser	6
Deep learning on reflectance confocal microscopy improves Raman spectral diagnosis of basal cell carcinoma	6
Implantable sensor for local Cherenkov-excited luminescence imaging of tumor pO2 during radiotherapy	6
Analysis of structural effects of sickle cell disease on brain vasculature of mice using three-dimensional quantitative phase imaging	6
Real-time tracking of a diffuse reflectance spectroscopy probe used to aid histological validation of margin assessment in upper gastrointestinal cancer resection surgery	6
Multimodal 3D photoacoustic remote sensing and confocal fluorescence microscopy imaging	6
Feasibility of combined optical coherence tomography and autofluorescence imaging for visualization of needle biopsy placement	6
Surface kinematic and depth-resolved analysis of human vocal folds in vivo during phonation using optical coherence tomography	6
Empirical method for rapid quantification of intrinsic fluorescence signals of key metabolic probes from optical spectra measured on tissue-mimicking turbid medium	6
Skin optical properties in the obese and their relation to body mass index: a review	6
Shortwave infrared spatial frequency domain imaging for non-invasive measurement of tissue and blood optical properties	6
Terahertz high-resolution spectroscopy of thermal decomposition gas products of diabetic and non-diabetic blood plasma and kidney tissue pellets	6
Characterizing a photoacoustic and fluorescence imaging platform for preclinical murine longitudinal studies	6
High-resolution three-dimensional blood flow tomography in the subdiffuse regime using laser speckle contrast imaging	6
Quantifying the confounding effect of pigmentation on measured skin tissue optical properties: a comparison of colorimetry with spatial frequency domain imaging	6
Incorporating early and late-arriving photons to improve the reconstruction of cerebral hemodynamic responses acquired by time-resolved near-infrared spectroscopy	6
Dual-emissive, oxygen-sensing boron nanoparticles quantify oxygen consumption rate in breast cancer cells	6
Using Fourier ptychography microscopy to achieve high-resolution chromosome imaging: an initial evaluation	6
Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography	6
Imaging of enthesitis by an LED-based photoacoustic system	6
Enhancement of in vivo cardiac photoacoustic signal specificity using spatiotemporal singular value decomposition	6
Estimation of diffuse Cherenkov optical emission from external beam radiation build-up in tissue	6
Lung tissue phantom mimicking pulmonary optical properties, relative humidity, and temperature: a tool to analyze the changes in oxygen gas absorption for different inflated volumes	6
Assessing corneal cross-linking with reverberant 3D optical coherence elastography	6
CNN-based CP-OCT sensor integrated with a subretinal injector for retinal boundary tracking and injection guidance	6
Investigation of photoacoustic tomography reconstruction with a limited view from linear array	6
Globally deployed COVID-19 fever screening devices using infrared thermographs consistently normalize high readings to afebrile range	6