Helicobacter

Article	Citations
Gastric Helicobacter pylori infection does not contribute to extraoral halitosis and its eradication cannot achieve substantial reduction of halitosis	96
Issue Information	93
Second‐ and Third‐Line Therapies for Helicobacter pylori Eradication in Slovenia: Data From 2013–2023 of the European Registry on	65
DNA starvation/stationary phase protection protein of Helicobacter pylori as a potential immunodominant antigen for infection detection	53
UreBimmunodominant epitope‐specificCD8+T‐cell responses were beneficial in reducing gastric symptoms inHelicobacter pylori‐infected individuals	52
Expansion of cagA Copy Number in Helicobacter pylori During Co‐Infection in a Mouse Model	50
A “new” option in Helicobacter pylori eradication: High‐dose amoxicillin dual therapy outperforms bismuth quadruple therapy in a high dual resistance setting	50
Indications of Helicobacter pylori Eradication Treatment and Its Influence on Prescriptions and Effectiveness (Hp‐ EuReg	49
Worldwide Phylogenetic and Clinical Risk Association of the Helicobacter pylori Outer Membrane Gen	48
Low‐dose or high‐dose amoxicillin in vonoprazan‐based dual therapy for Helicobacter pylori eradication? A systematic review and meta‐analysis	45
Tegoprazan‐Amoxicillin Dual Therapy for Helicobacter pylori Eradication: A Prospective, Randomized, Multicenter Study in Fujian, China	43
A real‐world exploratory study on the feasibility of vonoprazan and tetracycline dual therapy for the treatment of Helicobacter pylori infection in special populations with penicillin allergy o	41
Proteomic Profiling of Extracellular Vesicles Reveals Potential Biomarkers for Helicobacter pylori Infection and Gastric Cancer	40
Evidence‐Based Guidelines for the Diagnosis and Treatment of Helicobacter pylori Infection in Korea: 2025 Revised Edition	39
Efficacy and safety of minocycline quadruple therapy for Helicobacter pylori eradication: A meta‐analysis of RCTs	36
Optimal Duration of Bismuth‐Containing Quadruple Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta‐Analysis	35
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Seroprevalence of Helicobacter pylori infection among schoolchildren in southern Taiwan—A 20‐year longitudinal follow‐up	29
Issue Information	29
Droplet Digital PCR ‐Based Detection of Clarithromycin Resistance on Rapid Urease Test Samples Predicts	26
Bismuth, esomeprazole, metronidazole and amoxicillin or tetracycline as a first‐line regimen for Helicobacter pylori eradication: A randomized controlled trial	26
Roles of Gastric Non‐Helicobacter pylori Helicobacter Species in Gastric Disease Development: A Review	25
Letter to the Editor regarding the article: “Forty years of Helicobacter pylori infection and changes in findings at esophagogastroduodenoscopy”	25
Nationwide survey ofHelicobacter pyloriseropositivity and gastric atrophy in Zambia	24
Helicobacter pylori , Inflammation, and Long‐Term Outcome in Patients With Acute Myocardial Infarction: A Prospective Cohort Study	24

EUROHELICAN —Accelerating Gastric Cancer Reduction Through Helicobacter pylori	23
Prophylactic immunization to Helicobacter pylori infection using spore vectored vaccines	23
Efficacy of Tegoprazan‐Containing Sequential Eradication Treatment Compared to Esomeprazole‐Containing Sequential Eradication of Helicobacter pylori in South Korea, a Region With High Antimicro	22
Managing Helicobacter pylori as an Infectious Disease: Implementation of Antimicrobial Stewardship	22
Innate Immunity in Helicobacter pylori Infection and Gastric Oncogenesis	22
Perspectives from recent advances of Helicobacter pylori vaccines research	21
Whole genome sequencing reveals novel genetic mutations of Helicobacter pylori associating with resistance to clarithromycin and levofloxacin	21
Exosome‐Based Detection of Helicobacter pylori Infection and Clarithromycin Resistance in Children	21
Efficacy of bismuth for antibiotic‐resistant Helicobacter pylori strains eradication: A systematic review and meta‐analysis	21
Efficacy and Safety of Levofloxacin‐ Versus Moxifloxacin‐Based Nitazoxanide Quadruple Therapy as Second‐Line Treatment for Helicobacter pylori	21
Tegoprazan‐Based Triple Therapy for Helicobacter pylori Eradication: A Phase <	20
Cardia and non‐cardia gastric cancer risk associated with Helicobacter pylori in East Asia and the West: A systematic review, meta‐analysis, and estimation of population attributable fraction	20
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Association between genetic polymorphisms of NOD1, Interleukin‐1B, and cagA strain with low‐grade duodenal eosinophilia in Helicobacter pylori‐related dyspepsia	19
Assessing the Capabilities of Novel Open‐Source Artificial Intelligence—DeepSeek in Helicobacter pylori‐Related Queries	19
Authors' Reply to the Letter on “Is Tailored Bismuth Quadruple Therapy (With Clarithromycin or Furazolidone) Based on Fecal Molecular Susceptibility Testing in First‐Line Helicobacter pylori Er	19
Helicobacter pylori and Impaired Early Childhood Development—Evidence From a Birth Cohort Study From Ghana and Côte d'Ivoire	19
Host Genetic Variants Associated With Helicobacter pylori Infection: A Meta‐Analysis Combined With	18
Effect of Helicobacter pylori infection and its eradication on the expression of tight junction proteins in the gastric epithelium in relation to gastric carcinogenesis	18
Characterization of Fecal Microbial Communities in Patients With Type 2 Diabetes Mellitus Combined With Helicobacter pylori Infection	18
Development and Evaluation of a Multi‐Epitope Vaccine Based on P22 Virus‐Like Particles Targeting Helicobacter pylori	18
Efficacy and Safety of Keverprazan–Amoxicillin Dual Regimen in Initial Eradication of Helicobacter pylori	17
Vonoprazan and amoxicillin dual therapy as the first‐line treatment of Helicobacter pylori infection: A systematic review and meta‐analysis	16
Efficacy of Bismuth Quadruple Therapy in the Treatment of Helicobacter pylori‐Infected Peptic Ulcer Children in Vietnam	16
Helicobacter pylori infection prevalence in ambulatory settings in 2017–2019 in RUSSIA: The data of real‐world national multicenter trial	16
A Bidirectional Association Between Helicobacter pylori Infection and Hyperlipidemia: Clinical Evidence and Mechanistic Insights	16
Efficacy of Three Amoxicillin Doses in Vonoprazan Dual Therapy for Helicobacter pylori Eradication: A Randomized Noninferiority Trial	16
Characteristics of phenotypic antibiotic resistance of Helicobacter pylori and its correlation with genotypic antibiotic resistance: A retrospective study in Ningxia	15
The expression and function of theB7family inHelicobacter pyloriinfection and gastric carcinogenesis process	14
An Economic Evaluation of Family‐Based Versus Traditional Helicobacter pylori Screen‐and‐Treat Strategy: Based on Real‐World Data and Microsimulation Mod	14
Boosting the Anti‐ Helicobacter Efficacy of Azithromycin through Natural Compounds: Insights From In Vitro, In Vivo, Histopathological, and Molecular Doc	14
The Association of a Positive Fecal Immunochemical Test With the Risk of Gastroesophageal Cancer: An Age‐Sex‐ H. Pylori Exposure Matched Cohort Study and	14
Disruption of the gastric epithelial barrier in Correa's cascade: Clinical evidence via confocal endomicroscopy	14
Helicobacter pylori infection found during upper endoscopy performed for the diagnosis of celiac, inflammatory bowel diseases, and eosinophilic esophagitis: A multicenter pediatric European stu	14
Inquiry about methodology used to isolate multiple Helicobacter pylori strains from the same patient	14
Molecular detection of Helicobacter pylori and its genotypic antimicrobial resistance patterns in dyspeptic Mozambican patients	14
Effect of Lactobacillus gasseri BIO 6369 and Lacticaseibacillus rhamnosus <	14
Issue Information	13
The Gastric Microbiota Invade the Lamina Propria in Helicobacter pylori ‐Associated Gastritis and Precancer	13
Effects of prior antibiotic use on clarithromycin resistance in Helicobacter pylori	13
Changes of Helicobacter pylori Infection Status and Risk of Precancerous Lesions: A Prospective Cohort Study in Chinese Population	13
Effect of Helicobacter pylori eradication on gastric precancerous lesions: A systematic review and meta‐analysis	13
Elucidating the Pathogenic Role of Helicobacter pylori Infection in Hematologic Disorders: Mechanistic Insights and Future Perspectives	13
Interpretation the Results of Eradicating Helicobacter pylori Infection Causing Colorectal Cancer Could Be Cautious	13
Efficacy and Safety of Vonoprazan‐Based Dual, Triple, and Quadruple Therapies for Helicobacter pylori	13
Preventive effect of Helicobacter pylori eradication on the coronary heart diseases depending on age and sex with a median follow‐up of 51 months	13
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Urolithin B alleviates Helicobacter pylori‐induced inflammation and oxidative stress in mice	12
Gastric Cancer Endoscopic Screening in an Intermediate‐Risk Country—A Dual‐Center Pilot Program	12
Antibiotic Combinations in Bismuth‐Containing Quadruple Therapy for Helicobacter pylori Eradication: A Systematic Review and Network Meta‐Analysis	12

After 28 Years, Professor David Y. Graham Says Goodbye and Helicobacter Welcomes a New Editor	12
Reevaluating the Adverse Events With the Same‐Dosage Regimen in Hemodialysis Patients Undergoing Helicobacter pylori Eradication	12
The Interplay Between Helicobacter pylori and Suppressors of Cytokine Signaling (SOCS) Molecules in the Development of Gastric Cancer and Induction of Immune Response	12
Letter to the Editor: Efficacy of Lactobacillus spp. Supplementation in Helicobacter pylori Eradication: A Systematic Meta‐Analysis of Randomized Controlled Trials With Trial Sequential	12
Correlation of FUT3 and FUT6 Gene Polymorphisms With Helicobacter pylori	12
Antimicrobial screening involving Helicobacter pylori of nano‐therapeutic compounds based on the amoxicillin antibiotic drug	12
Cost‐Effectiveness of Population‐Based Helicobacter pylori Screening With Eradication for Optimal Age of Implementation	11
Efficacy and Safety of Tegoprazan‐Based Dual, Triple, and Quadruple Therapies in First‐Line Helicobacter pylori	11
Advances in Helicobacter pylori vaccine research: From candidate antigens to adjuvants—A review	11
Exploring the capacities of ChatGPT: A comprehensive evaluation of its accuracy and repeatability in addressing helicobacter pylori‐related queries	11
Optimizing Duration and Dosing Frequency of Vonoprazan–Amoxicillin Dual Therapy for Helicobacter pylori: A Multicenter Randomized Trial	11
Real‐World Effectiveness and Safety of Saccharomyces boulardii CNCM I‐745 as Adjunct Therapy for	11
Resilience of the Gut Microbiome to Short Proton Pump Inhibitor Therapy With or Without High‐Dosage L. reuteri in H. pylori	11
Efficacy and Safety of Vonoprazan in Dual/Triple/Quadruple Regimens Both in First‐Line and Rescue Therapy for Helicobacter pylori Eradication: A Systematic Review With Meta‐Analysis	11
Reply: Is Tailored Bismuth Quadruple Therapy (With Clarithromycin or Furazolidone) Based on Fecal Molecular Susceptibility Testing in First‐Line Helicobacter pylori Eradication Treatment More E	11
Histopathologically defined intestinal metaplasia in lesser curvature of corpus prior to Helicobacter pylori eradication is a risk factor for gastric cancer development	11
Concentration‐dependent effect of amoxicillin against clinical strains of Helicobacter pylori	11
Optimizing Benefits‐Harms of H. pylori Screen‐and‐Treat Programs Tailored to the Regional Settings	11
Evaluating the potency of zoliflodacin against Helicobacter pylori: In vitro activity and conserved GyrB target	11
Issue Information	11
Persistent advanced periductal fibrosis is and helicobacter pylori infection in post‐treatment of opisthorchiasis: Correspondence	11
Helicobacter hepaticus promotes liver fibrosis through oxidative stress induced by hydrogenase in BALB/c mice	10
Comparison between the GastroPanel test and the serum pepsinogen assay interpreted with the ABC method—A prospective study	10
Development of a modified ABC method among Helicobacter pylori infected but serum pepsinogen test‐negative individuals	10
Current role of tailored therapy in treating Helicobacter pylori infections. A systematic review, meta‐analysis and critical analysis	10
Empirical Therapy Versus Tailored Therapy of Helicobacter pylori in Korea: Results of the K‐ CREATE St	10
Interactions between Helicobacter pylori infection and host metabolic homeostasis: A comprehensive review	10
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Research trends on vonoprazan‐based therapy for Helicobacter pylori eradication: A bibliometric analysis from 2015 to 2023	10
Efficacy and Safety of Vonoprazan‐Based Dual Therapies With Different Antibiotics Versus Bismuth‐Containing Quadruple Therapy for Helicobacter pylori	10
Primary antibiotic resistance of Helicobacter pylori in India over the past two decades: A systematic review	10
Helicobacter pylori infection and rheumatoid arthritis as risk enhancers' factors for atherosclerotic cardiovascular diseases	10
Do atrophic gastritis and intestinal metaplasia reverse after Helicobacter pylori eradication?	10
Helicobacter pyloriCagA Promotes the Formation of Gallstones by Increasing the Permeability of Gallbladder Epithelial Cells	10
Helicobacter pylori‐positive chronic atrophic gastritis and cellular senescence	10
Drug Repurposing Identifies Natamycin and Avacopan as Urease‐Targeted Therapeutic Candidates Against Helicobacter pylori	9
Helicobacter pylori infection reduces the efficacy of cancer immunotherapy: A systematic review and meta‐analysis	9
Artificial Intelligence‐Generated Patient Education Materials for Helicobacter pylori Infection: A Comparative Analysis	9
Knowledge and Practices of Helicobacter pylori Infection Management Among Physicians in Gansu Province, China: A Cross‐Sectional Study	9
Long‐Term Effect of Helicobacter pylori Eradication on Gastric Atrophy and Intestinal Metaplasia A	9
Oral immunotherapy for Helicobacter pylori: Can it be trusted? A systematic review	9
Tracking the Helicobacter pylori Epidemic in Adults and Children in China	9
In vitro efficacy of combinations of antibiotics used in clinical practice on clinical isolates of Helicobacter pylori	9
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Quantitative PCR of string‐test collected gastric material: A feasible approach to detect Helicobacter pylori and its resistance against clarithromycin and levofloxacin for susceptib	9
Immunoinformatics‐Based Designing of Novel and Potent Multi‐Epitope PSA D15 and Cag11 Immunogens for Helicobacter pylori Immunodiagnostic Assay Development	9
Gastric mucosal swab as an alternative to biopsy for Helicobacter pylori detection	9
Prevalence and trends of multiple antimicrobial resistance of Helicobacter pylori in one tertiary hospital for 20 years in Korea	9
Management of Helicobacter pylori Infection in Spain Beyond the Data Collected in the European Registry on H. pylori Management (Hp‐EuReg): Results of a Nationwide Survey	9
Impact of mixed‐infection rate of clarithromycin‐susceptible and clarithromycin‐resistant Helicobacter pylori strains on the success rate of clarithromycin‐based eradication treatment	8
First‐Line Therapy for Helicobacter pylori in Slovenia: Data From 2013 to 2023 of the European Registry on H. pylori Management	8
Exploration of a Potential Amoxicillin MIC Threshold in Bismuth Quadruple Therapy for H. pylori	8
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Helicobacter pylori virulence genotypes in Bogotá River and wastewater treatment plants in Colombia	8
Issue Information	8
Intravenous metronidazole‐, levofloxacin‐containing triple therapy for treating patients with Helicobacter pylori‐related active peptic ulcer complications: A pilot study	8
Influence of oipA Phase Variation on Virulence Phenotypes Related to Type IV Secretion System in Helicobacter pylori	8
Antimicrobial Resistance of Helicobacter pylori Isolated From Latin American Children and Adolescents (2008–2023): A Systematic Review	8
Probiotic containing Lactobacillus reuteri DSM 17648 as an adjunct treatment for Helicobacter pylori infection: A randomized, double‐blind, placebo‐controlled trial	8
Seven‐Day Versus 14‐Day Tegoprazan and Tetracycline‐Containing Quadruple Therapy for First‐Line Eradication of Helicobacter pylori Infection: A Randomized, Open‐Label, Noninferiority	8
Impact of an Electronic Medical Record Quality Improvement Intervention on Helicobacter pylori Treatment and Eradication Rates in a U.S. Hospital System	7
Efficacy and Safety of Fexuprazan‐Based Modified High‐Dose Dual Therapy for Helicobacter pylori Er	7
Efficacy of tegoprazan‐based bismuth quadruple therapy compared with bismuth quadruple therapy for Helicobacter pylori infection: A randomized, double‐blind, active‐controlled study	7
Improvement in Helicobacter pylori Eradication Among Adults Receiving Semaglutide: A Population‐Based Propensity‐Score‐Adjusted Analysis	7
Network meta‐analysis of different dosages of esomeprazole and rabeprazole for the treatment of Helicobacter pylori	7
Individualized diagnosis and eradication therapy for Helicobacter pylori infection based on gene detection of clarithromycin resistance in stool specimens: A systematic review and meta‐analysis	7
A case of neonatal thrombocytopenia due to maternal Helicobacter pylori‐associated immune thrombocytopenia	7
REAP‐HP survey 2020: Comparing the real‐world practice and expectation in Helicobacter pylori eradication of the Taiwanese gastroenterologists in 2015 and 2020	7
Global Diversity of Helicobacter pylori Prophages Reveals Genetic Drivers of Virulence and Associa	7
Candidate Antigens and the Development of Helicobacter pylori Vaccines	7
Issue Information	7
Assessing Accuracy of ChatGPT on Addressing Helicobacter pylori Infection‐Related Questions: A Nationa	6
Helicobacter pylori and cardiovascular risk: Only a dead Helicobacter is a good Helicobacter?	6
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Forty years of Helicobacter pylori infection and changes in findings at esophagogastroduodenoscopy	6
Evaluation of Pepsinogen I, II, Gastrin 17 and Helicobacter pylori IgG in Atrophic Gastritis: A Head‐To‐Head Comparison of Lateral Flow and Enzyme‐Linked Immunosorbent Assays	6
Eradication rates of Helicobacter pylori in treatment‐naive patients following 14‐day vonoprazan‐amoxicillin dual therapy: A multicenter randomized controlled trial in China	6
Helicobacter pylori Eradication Primary Care First‐Line Prescriptions: Data From 200,000 Patients in a Real‐World Coho	6
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Vonoprazan Dual or Triple Therapy Versus Bismuth‐Quadruple Therapy as First‐Line Therapy for Helicobacter pylori Infection: A Three‐Arm, Randomized Clinical Trial	6

H. pylori predictors and outcomes among adults undergoing upper endoscopy at a Jamaican teaching hospital: A cross‐sectional study	6
Incidence of Gastric Cancer and Neuroendocrine Tumors in Autoimmune Gastritis: A Systematic Review and Meta‐Analysis of Follow‐Up Studies	6
Letter to the Editor: “Efficacy of Lactobacillus spp. Supplementation in Helicobacter pylori Eradication: A Systematic Meta‐Analysis of Randomized Controlled Trials With Trial Sequential	6
Issue Information	6
YouTube as a source of information on Helicobacter pylori: Content and quality analysis	5
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Combatting Helicobacter pylori: A Focus on Nanomaterials	5
Galangin Alleviates Helicobacter pylori Gastritis Through TLR2 Inhibition and Modulation of the	5
Helicobacter pylori Infection in Children: To Eradicate or Not to Eradicate?	5
Microbiome and function alterations in the gastric mucosa of asymptomatic patients with Helicobacter pylori infection	5
Tetracycline Three Times Daily Versus Four Times Daily in Bismuth‐Containing Quadruple Therapy as the First‐Line Treatment of Helicobacter pylori Infecti	5
A comprehensive evaluation of an animal model for Helicobacter pylori‐associated stomach cancer: Fact and controversy	5
Helicobacter pylori and Colorectal Cancer: Meeting Sir Austin Bradford Hill's Causality Criteria	5
Treatment failure is a key factor in the development of Helicobacter pylori resistance	5
Correction to Antimicrobial Resistance of Helicobacter pylori Isolated From Latin American Children and Adolescents (2008–2023): A Systematic Review	5
The role of toll‐like receptors in immune tolerance induced by Helicobacter pylori infection	5
Gastric Cancer Screening: Intention to Adhere and Patients' Perspective	5
Helicobacter pylori regulated microRNA map of human gastric cells	5
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Helicobacter pylori Management in Africa: A Survey of Diagnostic, Treatment, and Related Resources	5
Incidence of gastrointestinal malignancies increases in persons received eradication therapy for Helicobacter pylori: A cohort study	5
Correction to “Long‐Term Effects of Fecal Microbiota Transplantation on Gut Microbiota After Helicobacter pylori Eradication With Bismuth Quadruple Thera	5
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Application of cefuroxime in the eradication therapy of Helicobacter pylori infection: A review article	5
Helicobacter pylori Pathogenic Factors and Their Interactions With the Gastric Microbiome	5
Helicobacter pyloriresults in lysis and death after exposure to water	5
Antimicrobial Resistance Profile of Helicobacter pylori in Shenzhen, China: A Retrospective Study From 2021 to 2024	5
Clarifying varied Helicobacter pylori eradication therapies: A comprehensive review	5
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Antibiotic resistance, heteroresistance, and eradication success ofHelicobacter pyloriinfection in children	4
Antimicrobial‐resistant Helicobacter pylori in Japan: Report of nationwide surveillance for 2018–2020	4
The Optimal Age of Helicobacter pylori Screen‐and‐Treat for Gastric Cancer Prevention in the United States	4
Long‐term effects of fecal microbiota transplantation on gut microbiota after Helicobacter pylori eradication with bismuth quadruple therapy: A randomize	4
Helicobacter 30 Years On: A Message From the Editor, Emeritus	4
Helicobacter pylori Eradication Is Associated With a Reduced Risk of Metachronous Gastric Neoplasia by Restoring Immune Function in the Gastric Mucosa	4
High‐Dose Dual Therapy Versus Bismuth‐Containing Quadruple Therapy as Rescue Treatment for Helicobacter pylori Infection: Systematic Review and Meta‐Anal	4
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Overall and Stratified Accuracies of H. pylori Serology Testing: A Multicenter Study of 8497 Screening‐Naïve Adults	4
Eradication Rates of Empiric Helicobacter pylori Treatment Regimens by Race/Ethnicity in a Predomi	4
Issue Information	4
A pilot study evaluating high dose esomeprazole, bismuth subcitrate and amoxicillin for eradicating Helicobacter pylori infection in Iran	4
Risk of map‐like redness development after eradication therapy for Helicobacter pylori infection	4
Correction to “Tegoprazan‐Based Triple Therapy for Helicobacter pylori Eradication: A Phase III Multicenter Randomized Clinical Trial”	4
Optimization of Minocycline‐Containing Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Real‐World Evidence Study	4
Vonoprazan Improves Efficacy of Bismuth Quadruple Therapy for Helicobacter pylori Rescue Treatment: A Multicenter Randomized Controlled Trial	4
Fourteen‐Day Tegoprazan–Amoxicillin Dual Therapy as the First‐Line Treatment of Helicobacter pylori Infection (SHARE2301): A Multicenter, Noninferiority, Randomized Clinical Trial	4
Prevalence of Autoimmune Gastritis Worldwide: A Systematic Review and Meta‐Analysis	4
Vonoprazan‐amoxicillin dual therapy versus bismuth‐containing quadruple therapy for Helicobacter pylori eradication: A systematic review and meta‐analysis	4
Helicobacter pylori induces urease subunit B‐specific CD8+ T cell responses in infected individuals via cytosolic pathway of cross‐presentation	4
High Potency Proton Pump Inhibitor Versus Vonoprazan in Helicobacter pylori Triple Therapy	4
Issue Information	4
Efficacy of Bismuth Therapy in Eradicating Helicobacter pylori in Children—Data From the RENIHp Registry	4
The nonadherence and risk factors of eradication failure by sequential therapy as first‐line anti‐Helicobacter pylori treatment in real‐world clinical practice	4
Prevalence of multidrug‐resistant Campylobacter species in wastewater effluents: A menace of environmental and public health concern	4
Lipidome Characterization Reveals Alterations of Fatty Acid Metabolism in Helicobacter pylori Infection	4
TikTok and Bilibili as sources of information on Helicobacter pylori in China: A content and quality analysis	4
Vonoprazan‐based therapies versus PPI‐based therapies in patients with H. pylori infection: Systematic review and meta‐analyses of randomized controlled trials	4