OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 32. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-08-01 to 2026-08-01.)

Article	Citations
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	114
Issue Editorial Masthead	113
Issue Publication Information	105
Issue Publication Information	105
Issue Editorial Masthead	100
Issue Editorial Masthead	81
Issue Editorial Masthead	74
Evolution of the Synthesis Route for CC-99677: From Discovery toward Commercialization	63
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	61
Model Aided Scale-up for Wet Milling	55
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	52
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	49
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	47
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	47
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	46
Development of a Flow Process to tert -Butyl 4-(6-Chloropyridin-2-yl)piperidine-1-carboxylate	44
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	44
Advancing Arsenazo III Synthesis by Batch-to-Flow Translation and Additive Reactor Manufacturing	43
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	41
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	41
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	40
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	39
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	39
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	38
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	37

Continuous Flow Friedel–Crafts Acylation Reaction and Application to the Synthesis of Acetaminophen	37
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	37
Solvent Effects on Crystallization Kinetics: Investigating Trends across Scales, Methods, and Process Analytical Technologies	35
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	34
Application of an Interdisciplinary Approach to Form Selection in Drug Development	33
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	32
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	32