OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 31. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	180
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	100
Application of an Interdisciplinary Approach to Form Selection in Drug Development	65
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	63
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	62
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	56
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	54
Issue Editorial Masthead	52
Issue Editorial Masthead	51
Issue Publication Information	51
Issue Editorial Masthead	48
Issue Publication Information	48
Issue Editorial Masthead	47
Issue Publication Information	47
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	44
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	44
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	43
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	43
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	43
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	43
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	42
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	39
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	39
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	38
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	37

A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	37
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	37
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	36
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	36
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	32
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	31
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	31