OOIR: Observatory of International Research

Papers

(The H4-Index of Organic Process Research & Development is 30. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-08-01 to 2025-08-01.)

Article	Citations
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	191
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	111
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	68
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	68
Application of an Interdisciplinary Approach to Form Selection in Drug Development	60
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	58
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	57
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	57
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	55
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	54
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	52
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	50
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	50
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	46
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	45
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	45
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	40
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	39
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	38
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	38
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	34
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	34
Issue Editorial Masthead	32
Issue Publication Information	32
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	32

Issue Publication Information	32
Issue Editorial Masthead	30
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	30
Issue Publication Information	30
Issue Editorial Masthead	30
Issue Editorial Masthead	30