OOIR: Observatory of International Research

Papers

(The median citation count of Organic Process Research & Development is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2022-06-01 to 2026-06-01.)

Article	Citations
Streamlined Isolation of Magnesium Aryl Sulfinate Enabled by the Hydration of Sulfinate Salt to Magnesium Tetrahydrate	151
Issue Editorial Masthead	105
Issue Publication Information	104
Issue Publication Information	94
Issue Editorial Masthead	92
Issue Editorial Masthead	88
Issue Editorial Masthead	78
Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	75
Evolution of the Synthesis Route for CC-99677: From Discovery toward Commercialization	63
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	60
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	55
Model Aided Scale-up for Wet Milling	55
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	55
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	52
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	47
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	46
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	45
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	45
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	42
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	42
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	41
Development of a Flow Process to tert -Butyl 4-(6-Chloropyridin-2-yl)piperidine-1-carboxylate	41
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	40
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	40
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	38

Advancing Arsenazo III Synthesis by Batch-to-Flow Translation and Additive Reactor Manufacturing	37
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	35
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	34
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	34
Application of an Interdisciplinary Approach to Form Selection in Drug Development	34
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	33
A Scalable Process for Synthesizing a Reactive Silicone-Acrylate Monomer	32
Lessons Learned in Developing a Manufacturing Facility for Flow Chemistry	32
Solvent Effects on Crystallization Kinetics: Investigating Trends across Scales, Methods, and Process Analytical Technologies	32
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	32
Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities	31
Issue Publication Information	29
Issue Publication Information	29
Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions	28
Issue Publication Information	28
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl₂-BINOL	28
RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy	27
Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties	27
Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991	27
Risk Assessment Study of Nitrosamines for the API Temozolomide Industrial Process	27
Towards the Development of a Commercial Process To Produce Muvalaplin. Part I: Preparation of a Key Intermediate by an Evans Auxiliary-Assisted Asymmetric Alkylation	26
Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718	26
Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents	25
The Recombinant 3-Ketosteroid Δ ¹ -Dehydrogenase Catalyzed Δ ¹ -Dehydrogenation toward Total Synth	25
Bulk Mixing in a Milligram-Scale Solid Phase Batch Reactor	24
Optimizing the CHF6523 Isocoumarin Core Scaffold: From the Preclinical Stage to Large-Scale Production	24
Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs	24
Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole	24
Thermal Hazard Assessment of the Synthesis of 1,1′-Azobis-1,2,3-triazole	24
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1H-Tetrazoles	23
Screening Platform for Immobilized Biocatalysts Utilizing Miniature Rotating Bed Reactors	23
Scalable Synthesis of 6-Functionalized 1,4-Oxazepanes	23
Tetramethylchloroformamidinium Hexafluorophosphate– N -Methylimidazole Amidation in Water: Successes, Limitations, and a Regression Model for Prediction	22
Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry	22
One-Pot Synthesis of Guanidinium 5,5′-Azotetrazolate Avoiding Isolation of Hazardous Sodium 5,5′-Azotetrazolate	21
Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754	21
Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence	21
Continuous Flow Synthesis of a Silicon Isostere of DDT: Safe Chlorination of Trichloromethylsilane and Continuous Grignard Coupling	21
Development of a Sustainable Chemoenzymatic Process for (S)-Pregabalin Synthesis via Nitrilase-Catalyzed Hydrolysis and Continuous Flow Racemization	21
Enhancing the Sustainability and Scalability of Transition-Metal-Free Stereoretentive Decarboxylative Amidation with Dioxazolones	21
Approaches and Considerations for the Investigation and Synthesis of N-Nitrosamine Drug Substance-Related Impurities (NDSRIs)	21
Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009	20
Aqueous S _N Ar Reactions without a Surfactant: A Scalable Method That Uses Only Water from Start to Finish	20
Correction to “Evolution of the Synthesis Route for CC-99677: From Discovery Towards Commercialization”	20
Efficient and Improved Solution-Phase Synthesis of Modified RNA Dinucleotides: Versatile Synthons in Cap 1 mRNA Therapeutics	20
Yoshida-Type Equations: Perspectives from Thermal Analysis and Energetic Materials Research	20
Design Space Visualization and Technoeconomic Evaluation of a Batch Manufacturing Process for the Green Production of an Anti-cancer Drug (Adavosertib) Precursor	20
Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183	19
Process Development of the Novel LpxC Inhibitor T-1228. Part 4: Control of Mutagenic Impurities during API Synthesis	19
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena	19

Accelerating Process Innovation through Communications and Technical Notes	19
Process Development for Continuous Manufacturing of Baloxavir Marboxil. Part 2: Step 2 Synthesis	19
Continuous Reduction of an Ester to Aldehyde in CSTR: From Laboratory to Industrial Plant	18
Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker	18
Co-Catalyst Enabled Biotransformation of Polyunsaturated Fatty Acids for Biobased Monomers	18
Evaluating Resonant Acoustic Mixing as a Wet Granulation Process	17
Economic, One-Pot Synthesis of Diethyl Furoxan Dicarboxylate	17
A Short Review on the Synthetic Routes for the Antiepileptic Drug (S)-Levetiracetam	17
Stereoselective and Enantioselective Strategies for the Commercial-Scale Synthesis of Dorzolamide Hydrochloride	17
Polymorph and Salt/Cocrystal Screening to Identify a Suitable Physical Form for an LPAR1 Antagonist, GS-2278	17
Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug	17
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment	17
Thermal Decomposition Kinetics of Benzoyl Peroxide Based on Thermogravimetric Analysis and DFT Simulations	16
Characterization, Solubility, and Hygroscopicity of BMS-817399	16
Discovery of Oxazole Byproduct Formation in the Modified Dakin–West Reaction and Efficient Synthesis of Diastereomeric α-Ketoamide Cysteine Protease Inhibitors	16
Some Items of Interest to Process R&D Chemists and Engineers	16
Properties of Packed Bed Structures Formed during Filtration: A Two and Three-Dimensional Model	16
Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling Reaction	16
Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors	16
Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development	16
Novel Baeyer–Villiger Oxidation of Nucleosides Applied to the Large-Scale Synthesis of MeMOP: A Key Amidite in the GalXC Platform	16
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	16
Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment	15
Automatic Design of Wet-Milling-Integrated Batch Crystallization Processes by Process Analytical Technology-Based Split-Range Direct Nucleation Control	15
Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol	15
Decoding Reactions in Process Chemistry: A Quarter-Century Analysis of Trends and Transformations in OPR&D	15
A Critical Account of Synthetic Approaches toward Vildagliptin, an Antidiabetic Drug	15
Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents	15
Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis	14
Automated Image-Based Color Analysis as an Accessible and Widely Applicable PAT Tool	14
Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy	14
Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707	14
Development and Scale-Up of an Enabling Synthetic Route to KTX-005, a Muscarinic Acetylcholine Receptor Agonist for the Potential Treatment of Schizophrenia	14
Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate	14
Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876	14
Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease	14
Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies	13
Some Items of Interest to Process R&D Chemists and Engineers	13
“On-Water” Reaction of (Thio)isocyanate: A Sustainable Process for the Synthesis of Unsymmetrical (Thio)ureas	13
New Saturated Bicyclic Pyrrolidines: The Multigram Synthesis and Orthogonal Functionalization	13
Thermal Hazard Evaluation and Safety Considerations for the Use of O-Benzoyl-N-alkyl Hydroxylamines as Synthetic Reagents	13
Developing and Optimizing a Quench-Crystallization Operation in Drug Substance Manufacturing	13
Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO₂SCF₂H	13
Major Progress in the Liquid-Phase Synthesis of N -Alkyl-Rich Cyclic Peptides: Kilogram-Scale GMP Production of the KRAS Inhibitor LUNA18	13
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	13
Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients	13
Synthesis of a Pyridoazepine Scaffold via Rhodium-Catalyzed Ring Expansion and Nitroacetamide Condensation	13
Issue Publication Information	13
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19	13
Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O	13
Solid Acid-Enabled N -Boc Deprotection and Acetal Hydrolysis in the Synthesis of Vepdegestrant	13
An Alternative Route to the Anticancer Agent: 2-Fluorofucose from Readily Available L-(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination Reaction	12
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides	12
Expeditious and Automated Dispensing of ChemBeads for High-Throughput Experimentation in 384-Well Microtiter Plates	12
Development and Optimization of a Scalable Enzymatic Cascade-Carbamate Formation Telescope Process for the Synthesis of CDK2 Selective Candidate Tegtociclib (PF-07104091)	12
Optimization of Nitrosation Reaction for Synthesis of 4-Aminoantipyrine by Response Surface Methodology and Its Reaction Mechanism	12
Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis	12
Process Development of the Novel LpxC Inhibitor T-1228. Part 1: Synthesis of the Diol Fragment	12
Continuous Flow Synthesis of Esomeprazole via Asymmetric Sulfoxidation	12
Issue Publication Information	12
Development of a Scalable Anodic Oxidation Process for (R)-Troloxamide Quinone (EPI-589) Using a Continuous Flow Approach	12
A Chemoenzymatic Synthesis of STING Agonist MK-2118	12
Nitrosamine Risk Assessments in Oligonucleotides	12
Early Process Development of a Heterobifunctional Protein Degrader	12
An Easy and Adjustable One-Pot Access to Pheromonal Blends of Fall Armyworm (Spodoptera frugiperda) Relying on a Key Ligand- and Additive-Free Iron-Catalyzed Cross-Coupling	12
Issue Publication Information	12
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy	12
Scalable Process for Reduction of Aromatic Carboxylic Acids to Aldehydes via Pinacolborane	12
Toward Agile, Distributed Pharmaceutical Manufacturing: Continuous End-to-End Integration of Reaction, Purification, and Formulation for Lomustine via the MiniPharm Platform	12
Development of a Reliable Low-Loading Palladium-Catalyzed Monoamination Process for the Large-Scale Synthesis of 3-Bromo-2,5-difluoroaniline	12
Regulatory Highlights	11
Continuous Flow Synthesis of Crotonic Acid from Crotonaldehyde	11
Unique Superbase TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene): From Catalytic Activity and One-Pot Synthesis to Broader Application in Industrial Chemistry	11
Recent Advances in Nonprecious Metal Catalysis	11
Commercially Viable Synthesis of Medetomidine Using a Classical Approach to the Imidazole Ring Formation	11
Strategies for the Production of [¹¹C]LY2795050 for Clinical Use	11
A Confined Impinging Jet Reactor for High-Throughput Continuous Flow Mononitration of Salicylic Acid	11
Mass Transport of Diazomethane across Teflon AF2400 Membrane for Scale-Up Development	11
Some Items of Interest to Process R&D Chemists and Engineers	11
Evaluation and Removal of Production Process Constraints in the Synthesis of 3,5-Dibromopyrazole	11

A Novel, Practical, and Efficient Synthetic Process for Chiral 10-Aza-isoergoline Scaffold of the Antipsychotic Candidate IHCH7041	11
Continuous Flow Synthesis of DABCYL Azo Fluorescent Quenchers	11
Issue Editorial Masthead	11
Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction	11
Green and Low-Cost Synthesis of Thermally Stable Cation-Exchange Resin-Supported Diazonium Salt: An Example of Weakly Basic p-Nitroaniline Diazotization	11
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part III. Assembly of Drug Substance, Salt Formation, and Impurity Control	11
Issue Publication Information	11
Issue Publication Information	11
Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol	11
Integrating Process Safety Consideration to Enhance Route Development and Optimization	11
Continuous Manufacturing of Rocuronium Bromide Part 2: Step 2 Process Development	11
Process Development and Scale-Up of the Novel β-Lactamase Inhibitor WCK 6395	10
Optimized Method to Achieve 1-Hydroxy-5-aminotetrazole (HAT)	10
Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition	10
Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands	10
Practical and Efficient Approach to Scalable Synthesis of Rucaparib	10
Practical One-Pot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis-(2-nitrophenyl)-disulfides	10
Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine	10
Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF₄) and Dialkylamines in Continuous Flow Mode	10
Multigram-Scale Synthesis and Study of Reactivity of Two Difluoromethylating Reagents Based on Sulfoximine Skeletons	10
Some Items of Interest to Process R&D Chemists and Engineers	10
A Sustainable Approach to ε-Lys Branched GLP-1 Analogs: Integrating Green SPPS, Metal-free Alloc Removal, Waste Minimization and TFA/PFAS-free Resin Cleavage	10
Exploiting Undesired Solvate for Continuous Crystallization of Nitrofurantoin with Solid Form Transformation Process	10
Structure Determination of Synthesized Nitrosamine Drug Substance-Related Impurities (NDSRIs) Using 3D ED/MicroED	10
Scalable Continuous Flow Hydrogenation of Isoquinoline in Trickle-Bed Reactors	10
Continuous Crystallization of Atorvastatin Calcium at a Multitonnage Scale Using Dynamically Mixed Flow Reactors for Target Polymorph Control	10
Overcoming PAT Challenges in Automated Process Validation for Continuous Liquid–Gas Biphasic Processes	10
Correction to “Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts”	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source	10
Practical and Scalable Synthesis of 1,3-Adamantanediol	10
Stereoselective Construction of 3-(Aminoalkylidene)oxindoles in One Pot: Development of a Novel, Robust, and Scalable Process for the Multigram-Scale Preparation of Nintedanib	10
Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up	10
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry	10
Efficient and Scalable Synthesis of a Novel Selective PI3Kα Inhibitor XJTU-L453	10
Continuous Flow Intensification for the Synthesis of High-Purity Warfarin	10
Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale	10
Optimization of a Parham Cyclization Aided by In Situ FTIR for an Enabling Synthesis of Tricyclo[6.2.0.0^3,6]deca-1,3(6),7-trien-2-amine	9
Scalable Hydrophobic Tag-Assisted Convergent Synthesis of Cetrorelix Acetate	9
Issue Editorial Masthead	9
Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis	9
Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities	9
Reliable Calorimetric Method to Study the Incompatibilities between Hydrazine Hydrate and Metallic Impurities	9
Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination	9
Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes	9
Preparation of Impurity-Spiked Good Laboratory Practice Toxicological Batches of Active Pharmaceutical Ingredient Using Resonant Acoustic Mixing	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling	9
Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod	9
Issue Publication Information	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223	9
Benchtop NMR-Based In-Line Analysis of Diastereoselective Enzymatic α-Amino Acid Synthesis: Quantification and Validation	9
Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline	8
Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes	8
Process Development of the Pyrazinecarboxamide Component of Gilteritinib, a FLT3 Inhibitor	8
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling	8
Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution	8
In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth	8
Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactio	8
Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode	8
Continuous Manufacturing of Rocuronium Bromide. Part 1: Step 1 Process Development	8
Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A	8
Swiping Right on Palladium: Matching Precursors, Ligands, and Reaction Conditions	8
Route Optimization of the Noncovalent Modulator of Hemoglobin PF-07059013 for Treatment of Sickle Cell Disease through a Palladium-Mediated C–O Coupling, Part II: Pilot Plant Scale Manufacture	8
Issue Editorial Masthead	8
Issue Publication Information	8
Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Multigram, Chromatography-Free Synthesis of the Flavonol Morin	8
Correction to “Development of a Practical Telescoped Process to Prepare (P)-7-(2-Amino-6-fluorophenyl)-4-hydroxy-6-(trifluoromethyl)pyrido[3,4-d]pyrimidin-8(7H)-one: A Key Interme	8
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	8
Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors	8
Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis	8
Continuous-Flow Oxidation of Amines Based on Nitrogen-Rich Heterocycles: A Facile and Sustainable Approach for Promising Nitro Derivatives	8
Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine	8
Synthesis and Impurity Profiling of a Vital Intermediate in Gabapentin and Bispidine Derivative Pathways by Response Surface Methodology	8
Issue Editorial Masthead	8
Issue Publication Information	8
Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core	8
Issue Editorial Masthead	8
Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative	8
Methanol Steam Reforming Controls the Selective Transfer Hydrogenation vs N-Methylation of Nitrobenzene Using a PVP-Stabilized IrO₂ Nanoparticle Catalyst	8
Continuous Purification of a Conjugated Short Interfering RNA Therapeutic Using Anion Exchange Twin-Column Chromatography (MCSGP)	8
Issue Editorial Masthead	8
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	8
Technology Transfer and Process Development of Danicopan to Enable Process Validation	8
Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling	8
Scalable Flow Synthesis of Genetically Encodable Tetrazine Amino Acids	8
Efficient and Scalable Diastereoselective Synthesis of ((2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl)methanol Hydrochloride	8
Development of a Continuous Flow Synthesis of Lorazepam	8
Kilogram-Scale Preparation of the Amino Alcohol Fragment of Selgantolimod by Enzymatic Resolution of an α,α-Disubstituted Amino Ester	8
Review on Synthetic Approaches toward the Synthesis of Clozapine, an Antipsychotic Drug	7
Route Design and Scale-Up of a Topoisomerase I Inhibitor Antibody–Drug Conjugate Payload	7
Process Development and Optimization of Linagliptin Aided by the Design of Experiments (DoE)	7