OOIR: Observatory of International Research

Papers

(The median citation count of Organic Process Research & Development is 2. The table below lists those papers that are above that threshold based on CrossRef citation counts [max. 250 papers]. The publications cover those that have been published in the past four years, i.e., from 2021-06-01 to 2025-06-01.)

Article	Citations
Optimized Enzyme Production for the Escherichia coli Whole-Cell Biocatalytic Synthesis of Codeine from Thebaine	180
Practical Synthesis of 6-Amino-1-hydroxy-2,1-benzoxaborolane: A Key Intermediate of DNDI-6148	100
Application of an Interdisciplinary Approach to Form Selection in Drug Development	65
Improved Synthesis for the 4-Pyridone Intermediate of Baloxavir Marboxil: Elimination of Polar Aprotic Solvents and Optimization Through Design of Experiments (DoE)	63
Improved Acylation of Pseudoproline: Masked Threonine in Flow Peptide Chemistry	62
Comprehensive Analysis on the Synthesis Methods of 2-Phenylindole Derivatives with Pharmacological Importance for Green Synthesis	56
Modeling and Optimization of a Suspension Crystallization Separation Process for para-Xylene Purification	54
Issue Editorial Masthead	52
Issue Publication Information	51
Issue Editorial Masthead	51
Issue Editorial Masthead	48
Issue Publication Information	48
Issue Publication Information	47
Issue Editorial Masthead	47
HTE OS: A High-Throughput Experimentation Workflow Built from the Ground Up	44
Development of the Enabling Route for a Novel HCV NS3/4A Inhibitor, Furaprevir	44
Risk of Formaldehyde Contamination in Amines from Residual Dichloromethane	43
Ruthenium-Catalyzed Direct Asymmetric Reductive Amination for the Synthesis of a Chiral Primary Amine Intermediate En Route to a PDE2A Inhibitor, TAK-915	43
Benchmarking Strategies of Sustainable Process Chemistry Development: Human-Based, Machine Learning, and Quantum Mechanics	43
Development of Versatile Routes for the Preparation of an Intermediate to Immuno-Oncology Agonist BMS-986299	43
Balancing Yield, Purity, and Form: Finding the Sweet Spot for the Rework of the First Clinical Batch of Giredestrant (GDC-9545)	42
An Intramolecular Diels–Alder Approach to the Isoindolinone Core of AZD8154	39
An Improved and Scalable Process for Obtaining Pure Betaxolol Hydrochloride on an Industrial Scale	39
Quantitation of Reactive Nitrosating Agents in Pharmaceutical Excipients for N-Nitrosamine Risk Assessments	38
A Highly Efficient and Sustainable Biocatalytic Oxidation Process toward (R)-Undecavertol	37

Polymorphs, Particle Size, and a Pandemic: Development of a Scalable Crystallization Process for Molnupiravir, an Antiviral for the Treatment of COVID-19	37
Efficient Synthesis of Crisaborole from m-Cresol: A Practical and Scalable Process	37
Review of Synthetic Routes and Crystalline Forms of the Oncology Drugs Capmatinib, Selpercatinib, and Pralsetinib	36
Optimization and Scale-Up of a Continuous Flow Synthesis of Dapagliflozin	36
Enantioselective Synthesis of the Chiral Pyrrolidine Fragment of Upadacitinib via Chiral Auxiliary Directed Diastereoselective 1,3-Dipolar Cycloaddition	32
Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade	31
Kilogram-Scale GMP Manufacture of Tirzepatide Using a Hybrid SPPS/LPPS Approach with Continuous Manufacturing	31
A Scalable Process for Synthesizing a Reactive Silicone-Acrylate Monomer	30
Highly Selective Hydrogenation of Phenols to Cyclohexanone Derivatives Using a Palladium@N-Doped Carbon/SiO₂ Catalyst	29
Scale-Up Synthesis of 1-Methyladamantane and Its Functionalization as a Key Point for Promising Antiviral Agents	29
Precise Control of the Oxidation Reaction in a High-Purity Dexlansoprazole Synthesis Process Using In Situ Infrared	29
Preclinical Toxicology Supply for a Complex API Enabled by Asymmetric Catalysis and Rapid Chemical Development: IL-17A Inhibitor LY3509754	29
RIPPLY: Real-TIme Parallel Progress AnaLYsis of Organic Reactions Using Near-Infrared Spectroscopy	28
Issue Publication Information	28
Enhancing the Sustainability and Scalability of Transition-Metal-Free Stereoretentive Decarboxylative Amidation with Dioxazolones	28
Screening Platform for Immobilized Biocatalysts Utilizing Miniature Rotating Bed Reactors	28
Issue Publication Information	28
Issue Editorial Masthead	27
Risk Assessment Study of Nitrosamines for the API Temozolomide Industrial Process	27
Issue Publication Information	27
Development of a Sustainable Chemoenzymatic Process for (S)-Pregabalin Synthesis via Nitrilase-Catalyzed Hydrolysis and Continuous Flow Racemization	26
Excellence in Industrial Organic Synthesis 2021	26
Catalyst-Free, Scalable, Green-Light-Mediated Iodoamination, and Further Transformation of Olefins Under Continuous Flow Conditions	26
Citral-to-Menthol Transformations in a Continuous Reactor over Ni/Mesoporous Aluminosilicate Extrudates Containing a Sepiolite Clay Binder	26
Spherical Agglomeration of Safinamide Mesylate: A Case Study of a Simultaneous Control of Crystalline Landscape and Micromeritic Properties	25
One-Pot Synthesis of Guanidinium 5,5′-Azotetrazolate Avoiding Isolation of Hazardous Sodium 5,5′-Azotetrazolate	25
Thermal Hazard Assessment of the Synthesis of 1,1′-Azobis-1,2,3-triazole	24
Regulatory Highlights	23
Dynamic Spinning Disc Reactor Technology to Enable In Situ Solid Product Formation in a Diazotization and Azo Coupling Sequence	23
Efficient and Improved Solution-Phase Synthesis of Modified RNA Dinucleotides: Versatile Synthons in Cap 1 mRNA Therapeutics	23
Advancing Scalable Chemistry toward Novel CELMoDs: Process Development for the Synthesis of CC-90009	23
Exploiting the Physical Properties of Diethanolamine Boronic Esters for Process Improvements in AZD5718	22
Some Items of Interest to Process R&D Chemists and Engineers	22
One-Step, Catalyst-Free Continuous-Flow Method for the Rapid and Safe Synthesis of 1-Substituted 1H-Tetrazoles	22
Computer Vision for Kinetic Analysis of Lab- and Process-Scale Mixing Phenomena	22
Development of a Scalable Route toward an Alkylated 1,2,4-Triazol, a Key Starting Material for CXCR3 Antagonist ACT-777991	22
Analytical Strategy for Low-Level Estimation of Unstable Genotoxic Boronate Ester Impurities	22
Efficient Manufacturing Process for the Selective Estrogen Receptor Degrader GDC-9545 (Giredestrant) via a Crystallization-Driven Diastereoselective Pictet–Spengler Condensation	22
Large-Scale Synthesis of Chiral Tetrahydropyran via Asymmetric Allylation Catalyzed by (S)-3,3′-Cl₂-BINOL	22
Development of Continuous Flow Processes to Access Pyrrolo[2,1-f][1,2,4]triazin-4-amine: An RSM for the Synthesis of Antiviral Drugs	22
Asymmetric Synthesis of Optically Active 3-Cyclohexene-1-carboxylic Acid Utilizing Lactic Ester as a Chiral Auxiliary in the Diastereoselective Diels–Alder Reaction	22
Toward a Practical, Two-Step Process for Molnupiravir: Direct Hydroxamination of Cytidine Followed by Selective Esterification	22
Approaches and Considerations for the Investigation and Synthesis of N-Nitrosamine Drug Substance-Related Impurities (NDSRIs)	21
Lessons Learned in Developing a Manufacturing Facility for Flow Chemistry	21
Tracking the Isotopologues: Process Improvement for the Synthesis of a Deuterated Pyrazole	21
Highly Regioselective Protecting-Group-Free Synthesis of the Antimalarial Drug MMV693183	21
Highlights of the Recent Patent Literature: Continuous Chemistry in the Pharmaceutical Industry	21
Development and Scale-Up of an Enabling Synthetic Route to KTX-005, a Muscarinic Acetylcholine Receptor Agonist for the Potential Treatment of Schizophrenia	20
Characterization, Solubility, and Hygroscopicity of BMS-817399	20
Use of Impinging Jet to Improve Scalability in the Preparation of the ABBV-154 Drug-Linker	20

Synthetic Approaches toward Dabigatran Etexilate, an Oral Anticoagulant Drug	20
A Short Review on the Synthetic Routes for the Antiepileptic Drug (S)-Levetiracetam	20
Issue Publication Information	19
Economic, One-Pot Synthesis of Diethyl Furoxan Dicarboxylate	19
Thermal and Kinetic Research on a Highly Exothermic Condensation Reaction by Powerful Calorimeters	19
Novel Baeyer–Villiger Oxidation of Nucleosides Applied to the Large-Scale Synthesis of MeMOP: A Key Amidite in the GalXC Platform	19
Evaluating Resonant Acoustic Mixing as a Wet Granulation Process	19
Synthesis of Nirmatrelvir: Development of an Efficient, Scalable Process to Generate the Western Fragment	19
Properties of Packed Bed Structures Formed during Filtration: A Two and Three-Dimensional Model	19
“On-Water” Reaction of (Thio)isocyanate: A Sustainable Process for the Synthesis of Unsymmetrical (Thio)ureas	18
Case Studies in the Application of a Workflow-Based Crystallization Design for Optimized Impurity Rejection in Pharmaceutical Development	18
Large-Scale Amide Coupling in Aqueous Media: Process for the Production of Diazabicyclooctane β-Lactamase Inhibitors	18
Reaction of Irbesartan with Nitrous Acid Produces Irbesartan Oxime Derivatives, rather than N-Nitrosoirbesartan	18
Practical Asymmetric Synthesis of a Bicyclic Pyrrolidinol	18
Low-Level Quantification of tert-Butyl Nitrite in a Pharmaceutical Intermediate	18
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	17
Scalable Quasi-Divided Cell Operation Using Spinning Cylinder Electrode Technology: Multigram Electrochemical Synthesis of an Axitinib Intermediate	17
Some Items of Interest to Process R&D Chemists and Engineers	17
Rapid End-Game Process Development and First GMP Production of MK-7845: An Experimental Antiviral Treatment for COVID-19	17
Practical Kilogram Synthesis of (S)-1-Benzyl-4-Bromo-3-Methyl-1,2,3,6-Tetrahydropyridine	17
Improved Synthesis of the Selected Serine Protease uPA Inhibitor UAMC-00050, a Lead Compound for the Treatment of Dry Eye Disease	16
Cost-Efficient, Multigram Scalable Synthesis of Shelf-Stable Electrophilic (Phenylsulfonyl)difluoromethylating Reagents	16
Automated Image-Based Color Analysis as an Accessible and Widely Applicable PAT Tool	16
Thermal Decomposition Kinetics of Benzoyl Peroxide Based on Thermogravimetric Analysis and DFT Simulations	16
Development and Scale-Up of a Copper-Catalyzed Sulfamidation Coupling Reaction	16
Development of a Continuous Flow Process for the Efficient Preparation of Anti-Tuberculosis-Specific Drug TBAJ-876	16
Hydrogen Evolution from Telescoped Miyaura Borylation and Suzuki Couplings Utilizing Diboron Reagents: Process Safety and Hazard Considerations	16
Scale-Up of Diazonium Salts and Azides in a Three-Step Continuous Flow Sequence	16
Large-Scale Synthesis of LPA1-Receptor Antagonist ACT-1016-0707	16
Visible-Light Photocatalysis Academic–Industrial Collaboration Retrospective: Shared Learning and Impact Analysis	15
Synthesis of Nirmatrelvir: Development of Magnesium Sulfate-Mediated Aminolysis for the Manufacture of the Eastern Fragment	15
Manual to Auto-Optimization Platform of Multistep Apixaban Synthesis	15
A Critical Account of Synthetic Approaches toward Vildagliptin, an Antidiabetic Drug	15
Continuous-Flow Synthesis of Methyl Sulfone with Microchannel Reactors: A Safer and Efficient Production Strategy	15
Commercial Route Development of Sigma-2 Receptor Modulator, CT1812 Leveraging Photoflow, and HTS Technologies	15
An Alternative Route to the Anticancer Agent: 2-Fluorofucose from Readily Available L-(−)Rhamnose and Mechanistic Insights into a Zinc/Ammonium Iodide-Mediated Elimination Reaction	15
Defining the Qualities of High-Quality Palladium on Carbon Catalysts for Hydrogenolysis	15
A Proposal That Would Ban Manufacture, Supply, and Use of All Fluoropolymers and Most Fluorinated Reagents within the Entire EU	15
Strategies for the Production of [¹¹C]LY2795050 for Clinical Use	15
Gram-Scale Synthesis of Sulfoxides via Oxygen Enabled by Fe(NO₃)₃·9H₂O	15
An Easy and Adjustable One-Pot Access to Pheromonal Blends of Fall Armyworm (Spodoptera frugiperda) Relying on a Key Ligand- and Additive-Free Iron-Catalyzed Cross-Coupling	14
Catalytic Static Mixer-Enabled Hydrogenation of a Key Fenebrutinib Intermediate: Real-Time Analysis for a Stable and Scalable Process	14
Synthesis of a Pyridoazepine Scaffold via Rhodium-Catalyzed Ring Expansion and Nitroacetamide Condensation	14
Short and Efficient Synthesis of the Antituberculosis Agent Pretomanid from (R)-Glycidol	14
Issue Publication Information	14
Integrated Filtration and Washing Modeling: Optimization of Impurity Rejection for Filtration and Washing of Active Pharmaceutical Ingredients	14
Recent Advances in Nonprecious Metal Catalysis	14
Issue Publication Information	14
Accelerated Development of a Scalable Synthesis of CY6463, a CNS-Penetrant sGC Stimulator for the Treatment of Neurodegenerative Diseases	14
Issue Editorial Masthead	14
Synthetic and Chromatographic Challenges and Strategies for Multigram Manufacture of KRAS^G12C Inhibitors	14
Issue Publication Information	14
Scalable Synthesis of the Shelf-Stable Radical Difluoromethylthiolation Reagent S-(Difluoromethyl)benzenesulfonothioate PhSO₂SCF₂H	14
Optimization of Nitrosation Reaction for Synthesis of 4-Aminoantipyrine by Response Surface Methodology and Its Reaction Mechanism	14
Nitrosamine Risk Assessments in Oligonucleotides	13
Developing and Optimizing a Quench-Crystallization Operation in Drug Substance Manufacturing	13
Manufacturable Process of a Novel EGFR Inhibitor (Larotinib) for the Treatment of ESCC	13
Advancing Base-Metal Catalysis: Development of a Screening Method for Nickel-Catalyzed Suzuki–Miyaura Reactions of Pharmaceutically Relevant Heterocycles	13
Continuous Flow Synthesis of Esomeprazole via Asymmetric Sulfoxidation	13
Commercially Viable Synthesis of Medetomidine Using a Classical Approach to the Imidazole Ring Formation	13
Evaluation and Removal of Production Process Constraints in the Synthesis of 3,5-Dibromopyrazole	13
Engineering a Transaminase for the Efficient Synthesis of a Key Intermediate for Rimegepant	13
Engineering Enzyme Properties for Improved Biocatalytic Processes in Batch and Continuous Flow	13
Development of a Kilogram-Scale Synthesis of a Key Ulevostinag Subunit Part II: An Electrophilic Approach to Fluorinated Nucleosides	13
Evolution of a Green and Sustainable Manufacturing Process for Belzutifan: Part 1─Process History and Development Strategy	13
Unique Superbase TBD (1,5,7-Triazabicyclo[4.4.0]dec-5-ene): From Catalytic Activity and One-Pot Synthesis to Broader Application in Industrial Chemistry	13
Synthesis, Characterization, and Control Strategies for Cabazitaxel-Related Substances at Scale	12
Development of a Scalable Anodic Oxidation Process for (R)-Troloxamide Quinone (EPI-589) Using a Continuous Flow Approach	12
Green and Low-Cost Synthesis of Thermally Stable Cation-Exchange Resin-Supported Diazonium Salt: An Example of Weakly Basic p-Nitroaniline Diazotization	12
Deoxyfluorination of Ketones with Sulfur Tetrafluoride (SF₄) and Dialkylamines in Continuous Flow Mode	12
Optimized Method to Achieve 1-Hydroxy-5-aminotetrazole (HAT)	12
Issue Publication Information	12
Why and How to Control P-Chirality in Phosphorothioated Therapeutic Oligonucleotides: Analytical Challenges Associated with Determination of Stereochemical Composition	12
Practical and Efficient Approach to Scalable Synthesis of Rucaparib	12
Mass Transport of Diazomethane across Teflon AF2400 Membrane for Scale-Up Development	12
Issue Editorial Masthead	12
Continuous Flow Synthesis of Crotonic Acid from Crotonaldehyde	12
Regulatory Highlights	12
Development of Scalable Processes for the Preparation of 4-(chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene: A Key Intermediate for Siponimod	12
Robust Analytical Methods for Monitoring the Formation of a Chiral Oxazaborolidine Catalyst	12

Some Items of Interest to Process R&D Chemists and Engineers	12
Continuous Flow Telescopic Synthesis of 3-Methoxy Propiophenone by the Grignard Reaction	12
Integrated Flow Emulsion Electrosynthetic System by In Situ Generation of Emulsions, Subsequent Emulsion Electrolysis, and Final Phase Separation	12
Continuous Flow Enabled Synthesis of Multiresistant Drug Clofazimine	12
Issue Publication Information	12
A Confined Impinging Jet Reactor for High-Throughput Continuous Flow Mononitration of Salicylic Acid	12
Practical One-Pot Synthesis of 2-Alkyl-Substituted Benzothiazoles from Bis-(2-nitrophenyl)-disulfides	11
Stereoselective Construction of 3-(Aminoalkylidene)oxindoles in One Pot: Development of a Novel, Robust, and Scalable Process for the Multigram-Scale Preparation of Nintedanib	11
Continuous Flow Intensification for the Synthesis of High-Purity Warfarin	11
Copper-Catalyzed Hydroxylation of Aryl Halides Using Hydroxypicolinamide Ligands	11
Some Items of Interest to Process R&D Chemists and Engineers	11
Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes	11
Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19	11
Process Development and Scale-Up of the Novel β-Lactamase Inhibitor WCK 6395	11
Optimization and Development of a Scalable Palladium-Catalyzed C–H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator	11
Development of a Scalable Process for an IL-17A Inhibitor LY3509754: Part III. Assembly of Drug Substance, Salt Formation, and Impurity Control	11
Green Chemistry Articles of Interest to the Pharmaceutical Industry	11
Investigation of Wet Milling and Indirect Ultrasound as Means for Controlling Nucleation in the Continuous Crystallization of an Active Pharmaceutical Ingredient	11
Practical and Scalable Synthesis of 1,3-Adamantanediol	11
Synthesis of a Highly Functionalized Quinazoline Organozinc toward KRAS G12C Inhibitor Divarasib (GDC-6036), Enabled through Continuous Flow Chemistry	11
Hybrid Flow-Batch Model for the Efficient Synthesis of 2-(Dimethylamino)-6-methylpyridin-4-ol	11
Ketoprofen Solubility in Pure Organic Solvents Using In Situ FTIR and UV–Vis and Analysis of Solution Thermodynamics	11
Correction to “Application of Machine Learning and Reaction Optimization for the Iterative Improvement of Enantioselectivity of Cinchona-Derived Phase Transfer Catalysts”	11
Some Items of Interest to Process R&D Chemists and Engineers	11
Synthesis of Enantiopure Fluoropiperidines via Biocatalytic Desymmetrization and Flow Photochemical Decarboxylative Fluorination	11
Synthesis of Lenacapavir Sodium: Active Pharmaceutical Ingredient Process Development and Scale-up	11
Enabling Data-Driven Solubility Modeling at GSK: Enhancing Purge Predictions for Mutagenic Impurities	10
Benchtop NMR-Based In-Line Analysis of Diastereoselective Enzymatic α-Amino Acid Synthesis: Quantification and Validation	10
Reliable Calorimetric Method to Study the Incompatibilities between Hydrazine Hydrate and Metallic Impurities	10
Generation of 1,2-Difluorobenzene via a Photochemical Fluorodediazoniation Step in a Continuous Flow Mode	10
Multigram, Chromatography-Free Synthesis of the Flavonol Morin	10
Elevating 1-tert-Butyl-3-ethylcarbodiimide (TBEC) as a Reagent for Sustainable Peptide Synthesis: Quality Assessment and Minimizing Racemization, Precipitation, and Radical-Induced Side Reactio	10
Leveraging High-Throughput Experimentation to Drive Pharmaceutical Route Invention: A Four-Step Commercial Synthesis of Branebrutinib (BMS-986195)	10
Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors	10
Issue Editorial Masthead	10
Continuous-Flow Oxidation of Amines Based on Nitrogen-Rich Heterocycles: A Facile and Sustainable Approach for Promising Nitro Derivatives	10
Practical and Scalable Two-Step Process for 6-(2-Fluoro-4-nitrophenyl)-2-oxa-6-azaspiro[3.3]heptane: A Key Intermediate of the Potent Antibiotic Drug Candidate TBI-223	10
Scaling Up Gas–Liquid Photo-Oxidations in Flow Using Rotor-Stator Spinning Disc Reactors and a High-Intensity Light Source	10
Preparation of Impurity-Spiked Good Laboratory Practice Toxicological Batches of Active Pharmaceutical Ingredient Using Resonant Acoustic Mixing	10
Efficient Synthesis of a Key Intermediate for Baloxavir Marboxil from a Greener Starting Material: Ethylene Glycol	10
Green Chemistry Articles of Interest to the Pharmaceutical Industry	10
Assessment of Sulfur Impurities in GMP-Grade Diisopropylcarbodiimide and Their Impact on Coupling Reagent-Induced Side Reactions in Peptide Synthesis	10
Issue Publication Information	10
Veliparib: Analytical Tools and Process Design Strategies for the Control of Mutagenic Impurities and Other Drug Substance Critical Quality Attributes	10
Digital Design of Filtration and Washing of Active Pharmaceutical Ingredients via Mechanistic Modeling	10
Development of a Continuous Flow Baldwin Rearrangement Process and Its Comparison to Traditional Batch Mode	10
Demonstration of a Multikilogram-Scale Birch Reduction and Evaluation of Alternative Synthetic Routes to a Ketalized Cyclohexene Derivative	10
Study on the Safety Design of 3-Amino-6-Bromo-1,2,4-Triazine Drying Process Based on Thermal Analysis Technology	10
Some Items of Interest to Process R&D Chemists and Engineers	10
Investigation of Lithium Acetyl Phosphate Synthesis Using Process Analytical Technology	10
Development of a Continuous Flow Synthesis of Lorazepam	9
Opportunities and Challenges in Mechanochemical Cocrystallization toward Scaled-Up Pharmaceutical Manufacturing	9
Overriding Innate Decomposition Temperatures of an Avibactam Prodrug Precursor Using Data Science-Guided Synthesis	9
Development of a Scalable Manufacturing Process for Alectinib with a Concise Preparation of the Indole-Containing Tetracyclic Core	9
Kilogram-Scale Synthesis of 2′-C-Methyl-arabino-Uridine from Uridine via Dynamic Selective Dipivaloylation	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Synthesis and Impurity Profiling of a Vital Intermediate in Gabapentin and Bispidine Derivative Pathways by Response Surface Methodology	9
Opportunities for the Application and Advancement of the Corey–Chaykovsky Cyclopropanation	9
Regioisomer Formation with Agmatine Guanidino Group, Its Implications for Agmatine Peptide Cyclization, and Application of Bis-Boc-Agmatine	9
Acetonitrile Regeneration from Oligonucleotide Production Waste Streams	9
Advances and Opportunities Concerning Nucleation Measurement and Control Technology in Crystallization	9
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution	9
Safety Considerations and Proposed Workflow for Laboratory-Scale Chemical Synthesis by Ball Milling	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Kilogram-Scale Preparation of the Amino Alcohol Fragment of Selgantolimod by Enzymatic Resolution of an α,α-Disubstituted Amino Ester	9
Practical Synthesis of Chiral 3-(Hydroxyiminomethyl)adipic Acid, a Key Intermediate of the ROR-γ Inhibitor JTE-151, via Crystallization-Induced Dynamic Resolution	9
Process Development of the Pyrazinecarboxamide Component of Gilteritinib, a FLT3 Inhibitor	9
Some Items of Interest to Process R&D Chemists and Engineers	9
Thermal Safety and Structure-Related Reactivity Investigation of Five-Membered Cyclic Sulfamidates	9
Recent Advances in Nonprecious Metal Catalysis	9
Process Safety from Bench to Pilot to Plant	9
In Silico Prediction of Pharmaceutical Degradation Pathways: A Benchmarking Study Using the Software Program Zeneth	9
Quantum Mechanical Methods for Thermal Hazard Risk Assessment in Early Phase Pharmaceutical Development	9
Scalable Process of Spiro(cyclopropane)oxazepane Pyridine Carboxylic Acid through Kulinkovich, Mitsunobu, and Pd-Catalyzed Intramolecular C–N Coupling	9
Highly Efficient and Selective Hydrogenation of Sugars Catalyzed by Ru-MACHO-BH: Practical Synthesis of Sugar Alcohols	9
Technology Transfer and Process Development of Danicopan to Enable Process Validation	9
Fully Continuous Flow Synthesis of 5-(Aminomethyl)-2-methylpyrimidin-4-amine: A Key Intermediate of Vitamin B₁	9
Expeditious Synthesis of a Potent Allosteric HIV-1 Integrase Inhibitor GSK3839919A	9
Risk Assessment of the Leachables’ Profile for Small-Molecule Pharmaceutical Drug Substances	9
Initial Route Scouting and Final Process Development for the Multi-Kg Production of 3-Fluoro-6-methoxyquinoline from p-Anisidine and 2-Fluoromalonic Acid	9
Actual Process Impurity or an Analytical Artifact? A Case Study Involving Conversion of Amide to Nitrile to Uncover the Truth and Mitigate	8
Continuous Synthesis of 1,3,2-Dioxathiolane 2,2-Dioxide (DTD) by Hydrogen Peroxide with Titanium Silicalite-1 Catalyst Using a Fixed-Bed Reactor	8
Some Items of Interest to Process R&D Chemists and Engineers	8
Transformation of the Manufacturing Process from Discovery to Kilogram Scale for AWZ1066S: A Highly Specific Anti-Wolbachia Drug Candidate for a Short-Course Treatment of Filariasis	8
Development of a Safe and Scalable Method to Prepare 3-Bromo-N-alkyl-1,6-naphthyridones via Enamine Cyclization	8
Scalable Synthesis of CVN424, an Inverse Agonist of the GPR6 Receptor	8
Route Design and Scale-Up of a Topoisomerase I Inhibitor Antibody–Drug Conjugate Payload	8
Review on Synthetic Approaches toward the Synthesis of Clozapine, an Antipsychotic Drug	8
Practical and Scalable Synthesis of 5,6-Dichlorofurazano[3,4-b]pyrazine	8
Process Development and Optimization of Linagliptin Aided by the Design of Experiments (DoE)	8
Access to Cyclopropanol via Supply-Centered Synthesis	8
A Tandem Ring Closure and Nitrobenzene Reduction with Sulfide Provides an Improved Route to an Important Intermediate for the Anti-Tuberculosis Drug Candidate Sutezolid	8
Correction to “Some Items of Interest to Process R&D Chemists and Engineers”	8
Development of a High-Throughput Kinetics Protocol and Application to an Aza-Michael Reaction	8
A Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC	8